Aliases & Classifications for Scotoma

MalaCards integrated aliases for Scotoma:

Name: Scotoma 12 76 29 15
Generalized Visual Field Contraction or Constriction 12
Sector or Arcuate Visual Field Defects 12
Enlarged Paracaecal Scotoma 12
Scotoma of Blind Spot Area 12
Blind Spot Area Scotoma 12
Enlarged Angioscotoma 12
Enlarged Blind Spot 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9335
SNOMED-CT 68 193673000 33970004

Summaries for Scotoma

MalaCards based summary : Scotoma, also known as generalized visual field contraction or constriction, is related to optic nerve disease and optic atrophy 1. An important gene associated with Scotoma is ABCA4 (ATP Binding Cassette Subfamily A Member 4), and among its related pathways/superpathways is the visual cycle I (vertebrates). The drugs Labetalol and Nifedipine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and retina.

Wikipedia : 76 A scotoma (Greek σκότος/skótos, darkness; plural: scotomas or scotomata) is an area of partial... more...

Related Diseases for Scotoma

Diseases related to Scotoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 optic nerve disease 29.3 MT-ND4 OPA1 TMEM126A
2 optic atrophy 1 11.0
3 optic atrophy 5 11.0
4 cone-rod dystrophy 2 10.8
5 migraine, familial hemiplegic, 1 10.8
6 mohr-tranebjaerg syndrome 10.8
7 migraine, familial hemiplegic, 2 10.8
8 birdshot chorioretinopathy 10.8
9 migraine, familial hemiplegic, 3 10.8
10 optic atrophy 7 with or without auditory neuropathy 10.8
11 familial hemiplegic migraine 10.8
12 retinitis 10.3
13 aging 10.2
14 macular degeneration, age-related, 1 10.2
15 retinitis pigmentosa 19 10.1 ABCA4 KCNMA1
16 spastic paraplegia 7, autosomal recessive 10.0 MT-ND4 OPA1
17 strabismus 10.0
18 neuritis 10.0
19 macular holes 9.9
20 headache 9.9
21 3-methylglutaconic aciduria, type iii 9.8 MT-ND4 OPA1 TMEM126A
22 systemic lupus erythematosus 9.8
23 retinal detachment 9.8
24 stargardt disease 9.8
25 cataract 9.8
26 amblyopia 9.8
27 open-angle glaucoma 9.8
28 choroiditis 9.8
29 uveitis 9.8
30 cerebritis 9.8
31 adenoma 9.8
32 lupus erythematosus 9.8
33 anterior uveitis 9.8
34 aneurysm 9.8
35 pituitary tumors 9.8
36 stroke, ischemic 9.6
37 astigmatism 9.6
38 hepatitis c virus 9.6
39 hepatitis 9.6
40 retinal vein occlusion 9.6
41 sinusitis 9.6
42 cytomegalovirus retinitis 9.6
43 migraine with aura 9.6
44 neuroretinitis 9.6
45 endocarditis 9.6
46 myopia 9.6
47 optic neuritis 9.6
48 toxic optic neuropathy 9.6
49 hepatitis c 9.6
50 melanoma 9.6

Graphical network of the top 20 diseases related to Scotoma:



Diseases related to Scotoma

Symptoms & Phenotypes for Scotoma

Drugs & Therapeutics for Scotoma

Drugs for Scotoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Labetalol Approved Phase 4 36894-69-6 3869
2
Nifedipine Approved Phase 4 21829-25-4 4485
3
Methyldopa Approved Phase 4 555-30-6 38853
4 Adrenergic Agents Phase 4,Not Applicable
5 Adrenergic beta-Antagonists Phase 4
6 Neurotransmitter Agents Phase 4,Not Applicable
7 Peripheral Nervous System Agents Phase 4,Not Applicable
8 Antihypertensive Agents Phase 4
9 Autonomic Agents Phase 4,Not Applicable
10 calcium channel blockers Phase 4
11 Adrenergic Agonists Phase 4
12 Adrenergic alpha-1 Receptor Antagonists Phase 4
13 Adrenergic alpha-2 Receptor Agonists Phase 4
14 Adrenergic alpha-Agonists Phase 4
15 Adrenergic alpha-Antagonists Phase 4
16 Adrenergic Antagonists Phase 4
17 Sympatholytics Phase 4
18 Tocolytic Agents Phase 4
19 Vasodilator Agents Phase 4
20 Calcium, Dietary Phase 4
21
Ranibizumab Approved Phase 3,Phase 1,Phase 2 347396-82-1 459903
22
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
23
Bevacizumab Approved, Investigational Phase 3 216974-75-3
24 Angiogenesis Inhibitors Phase 3,Phase 1,Phase 2,Not Applicable
25 Angiogenesis Modulating Agents Phase 3,Phase 1,Phase 2,Not Applicable
26 triamcinolone acetonide Phase 3
27 glucocorticoids Phase 3
28 Hormone Antagonists Phase 3
29 Triamcinolone diacetate Phase 3
30 Triamcinolone hexacetonide Phase 3
31 Hormones Phase 3
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
33 Immunosuppressive Agents Phase 3
34 Anti-Inflammatory Agents Phase 3
35
Idebenone Approved, Investigational Phase 2 58186-27-9
36
Imidacloprid Vet_approved Phase 2 105827-78-9 86418
37 Ubiquinone Phase 2
38 Micronutrients Phase 2
39 Trace Elements Phase 2
40 Antioxidants Phase 2
41 Protective Agents Phase 2
42 Vaccines Phase 1
43
Menthol Approved Not Applicable 2216-51-5 16666
44
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
45
Methylphenidate Approved, Investigational Not Applicable 113-45-1 4158
46
Latanoprost Approved, Investigational 130209-82-4 5282380 5311221
47
Methamphetamine Approved, Illicit Not Applicable 537-46-2 10836
48
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
49
Lutein Approved, Investigational, Nutraceutical Not Applicable 127-40-2 6433159
50 Tomato Approved, Nutraceutical Not Applicable

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 Early Vascular Adjustments During Hypertensive Pregnancy Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
2 Serial Retinal Thickness Changes And Scotoma Size Measured With Lucentis Therapy Unknown status NCT01255774 Phase 3 ranibizumab
3 Paraorbital-Occipital Alternating Current Stimulation Therapy of Patients With Post-Chiasmatic Lesions Unknown status NCT01418820 Phase 2, Phase 3
4 Bevacizumab Versus Ranibizumab for Diabetic Retinopathy Completed NCT00545870 Phase 3 bevacizumab;Ranibizumab
5 Low Vision Depression Prevention Trial for Age Related Macular Degeneration Completed NCT00769015 Phase 3
6 Retinal Effects After Combined Photodynamic Therapy (PDT) With Intravitreal Triamcinolone Completed NCT00685100 Phase 3
7 A Phase III Study of A01016 in Subjects With Symptomatic Vitreomacular Adhesion Completed NCT01889251 Phase 3 Ocriplasmin;Sham injection
8 Scotoma Reduction in AMD Patients Treated With Ranibizumab Completed NCT00467935 Phase 1, Phase 2 intravitreal injection Lucentis (ranibizumab)
9 Evaluation of Eye Movement Tracking Systems for Visual Rehabilitation Completed NCT00013429 Phase 2
10 Low Vision Study Comparing EV Training vs. CCTV for AMD Rehabilitation Completed NCT00971464 Phase 2
11 Ranibizumab to Treat Type 2 Idiopathic Macular Telangiectasia (RAMA-Trial) Completed NCT00504400 Phase 2 Intravitreal injection ranibizumab
12 Study to Assess Efficacy,Safety and Tolerability of Idebenone in the Treatment of Leber's Hereditary Optic Neuropathy Completed NCT00747487 Phase 2 Idebenone;Placebo
13 Clinical Trial on Remote Ischemic Conditioning and Hypertension(HOPE) Not yet recruiting NCT03566654 Phase 2
14 Ciliary Neurotrophic Factor (CNTF) Safety Trial in Patients With Macular Telangiectasia (Mactel) Completed NCT01327911 Phase 1
15 Study to Compare Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE) Using a New Fast German Adaptive Threshold Estimation (GATE) in Glaucoma Patients Unknown status NCT00902109
16 Bipolar Radiofrequency Ablation Plus Argon Beam Coagulator Ablation for Atrial Fibrillation Unknown status NCT02424110 Not Applicable
17 Visuomotor Rehabilitation Training for Manual Task Deficits From Macular Scotomas Completed NCT01691027 Not Applicable
18 A Study to Determine the Location of the Blind Spot and the Macula-disc Centre Distance on a Fundus Photograph Completed NCT01843582
19 The Use of Transcranial Direct Current Stimulation (TDCS) to Enhance the Rehabilitative Effect of Vision Restoration Therapy Completed NCT00921427 Early Phase 1
20 Sparing of the Fovea in Geographic Atrophy Progression Completed NCT02332343
21 Detection of Topographic Residual Acuity in Patients With Age Related Macular Degeneration Completed NCT00329277 Not Applicable
22 Effects of Lutein Supplementation on Macular Pigment Optical Density and Visual Acuity in Patients With Age-related Macular Degeneration Completed NCT00879671 Not Applicable
23 A Clinical Study of Fundus Findings in Toxaemia of Pregnancy Completed NCT03076619
24 Mid-term Evaluation of Metamorphopsia in Epiretinal Membrane Surgery Completed NCT03045367
25 Indocyanine Green or Trypan Blue for Delamination of the Internal Limiting Membrane in Macular Hole Surgery Completed NCT00419185 Not Applicable
26 Age-related Normative Values for the Octopus 900 Perimeter Completed NCT01518686 Not Applicable
27 Assessment of Advanced Glaucomatous Visual Field Loss and Its Impact on Visual Exploration, Activities of Daily Living (ADL) and Quality of Life (QoL) Completed NCT01372319
28 Efficacy of Over-glasses Patch Treatment for Amblyopia in Children : OPTA Study Completed NCT03080285 Not Applicable
29 Methylphenidate Effect on Humphrey Visual Fields Completed NCT02162381 Not Applicable methylphenidate
30 The Zeaxanthin and Visual Function Study Completed NCT00564902 Not Applicable 3R 3'R Zeaxanthin
31 Observational Study of the Long-term Effect of Latanoprost in Normal Tension Glaucoma Completed NCT01209624
32 Non-Interventional Study In Patients With Ocular Hypertension And Open Angle Glaucoma Treated With Xalatan And Xalacom Completed NCT01012245
33 Head Mounted Eye Tracking Aide for Loss of Central Vision (HETALCEV) Recruiting NCT02829606 Not Applicable
34 Smartphone Flicker Fusion Test for Patients With Optic Disorders. Recruiting NCT03475147
35 Effect of the Membrane Blue Dual® Dye on the Retinal Sensitivity in Macular Hole Surgery Recruiting NCT02894424
36 Telescope Exchange Study Recruiting NCT03011554 Not Applicable
37 Evaluation of Near Visual Acuity With ODYSIGHT, a Smartphone Based Medical App in Comparison to a Standardized Method Recruiting NCT03457441 Not Applicable
38 Selective Retinal Pigment Epithelium Laser Therapy for Macular Disease of the Retina Recruiting NCT02088151 Not Applicable
39 Oxidative Stress and Endothelial Function in Pregnancy Complications Recruiting NCT02603913
40 Surgery, Tissue Plasminogen Activator, Antiangiogenic Agents and Age Related Macular Degeneration Complications Recruiting NCT02557451 Not Applicable
41 New Non-invasive Modalities for Assessing Retinal Structure and Function Recruiting NCT03475173 Not Applicable
42 Motivational Interviewing With Focus on Diet and Weight Gain in Pregnant Women With Type 2 Diabetes Recruiting NCT02883127
43 Effectiveness of Training in Reading Rehabilitation for Patients With Diabetic Macular Oedema Active, not recruiting NCT02457884 Not Applicable
44 Comparison of Visual Fields: Humphrey Field Analyzer (HFA) SITA Strategy, SCOPE (GATE Strategy) and Humphrey MATRIX Perimeter Active, not recruiting NCT01068938
45 Clinical Study of LPI With Different Laser Wavelengths Active, not recruiting NCT02901730 Not Applicable
46 Clinical Study of LPI on Different Sites of Iris Active, not recruiting NCT02870504 Not Applicable
47 Treatment Trial for Acute Central Serous Chorioretinopathy Enrolling by invitation NCT02784665 Not Applicable
48 Evaluation of Visual Function and Driving Health Using Ocusweep in Patients Suffering From Wet Age-related Macular Degeneration Enrolling by invitation NCT02747368 Not Applicable
49 " Sweeper " and Epiretinal Membrane Surgery Not yet recruiting NCT03350607
50 Objective Assessment of Macular Function at Retinal and Cortical Levels Not yet recruiting NCT03517241

Search NIH Clinical Center for Scotoma

Genetic Tests for Scotoma

Genetic tests related to Scotoma:

# Genetic test Affiliating Genes
1 Scotoma 29

Anatomical Context for Scotoma

MalaCards organs/tissues related to Scotoma:

41
Eye, Testes, Retina, Endothelial, Liver, Cortex, Pituitary

Publications for Scotoma

Articles related to Scotoma:

(show top 50) (show all 239)
# Title Authors Year
1
A Case of Complete Scotoma Following Intake of Conjugated Linoleic Acid Supplement. ( 29878339 )
2018
2
Factors associated with the presence of parafoveal scotoma in glaucomatous eyes with optic disc hemorrhages. ( 29973693 )
2018
3
Central Scotoma after Removal of Silicone Oil in Retinal Detachment: A Multimodal Imaging Case Report. ( 29490394 )
2018
4
A Middle-aged Woman With Vision Loss and Cecocentral Scotoma. ( 29955763 )
2018
5
Simulation of a central scotoma using contact lenses with an opaque centre. ( 29265475 )
2018
6
Central scotoma in tobacco-alcohol toxic optic neuropathy measured with semi-automated kinetic perimetry. ( 29688089 )
2018
7
Hemicrania Continua Associated with Classic Scintillating Scotoma. ( 29681827 )
2018
8
Sudden paracentral scotoma in a middle-aged male. ( 29930461 )
2018
9
Contrast Sensitivity in Eyes with Central Scotoma: Effect of Stimulus Drift. ( 29561506 )
2018
10
Retinal slippage fold causing a matching contralateral scotoma. ( 28395868 )
2017
11
Predicting the risk of parafoveal scotoma in myopic normal tension glaucoma: role of optic disc tilt and rotation. ( 28282064 )
2017
12
Acquired unilateral scotoma. ( 28684101 )
2017
13
Artificial scotoma estimation based on population receptive field mapping. ( 29253656 )
2017
14
SCOTOMA CHARACTERISTICS IN MACULAR TELANGIECTASIA TYPE 2: MacTel Project Report No. 7-The MacTel Research Group. ( 28609329 )
2017
15
Ocular and Systemic Risk Factors of Different Morphologies of Scotoma in Patients with Normal-Tension Glaucoma. ( 28815087 )
2017
16
Homeostatic plasticity in human extrastriate cortex following a simulated peripheral scotoma. ( 28821922 )
2017
17
Usefulness of frequency doubling technology perimetry 24-2 in glaucoma with parafoveal scotoma. ( 28614218 )
2017
18
Temporal crescent syndrome vs arcuate scotoma. ( 28318737 )
2017
19
Retinal Nerve Fiber Layer Defect and Paracentral Scotoma after Internal Limiting Membrane Peeling with a Nitinol Loop. ( 29276228 )
2017
20
TEMPORAL THINNING IN SICKLE CELL RETINOPATHY IS ASSOCIATED WITH DIMINISHED PERFUSION ON OCTA AND DENSE SCOTOMA ON MICROPERIMETERY. ( 28644178 )
2017
21
Structure-Function Relationship in Glaucoma Patients With Parafoveal Versus Peripheral Nasal Scotoma. ( 26848881 )
2016
22
Characteristics of the preferred retinal loci of better and worse seeing eyes of patients with a central scotoma. ( 27769327 )
2016
23
Comparison of retinal vessel diameter between open-angle glaucoma patients with initial parafoveal scotoma and peripheral nasal step. ( 27916714 )
2016
24
MAPPING THE DENSE SCOTOMA AND ITS ENLARGEMENT IN STARGARDT DISEASE. ( 26909568 )
2016
25
Optic Disk Pit with Sudden Central Visual Field Scotoma. ( 27872777 )
2016
26
Assessing the GOANNA Visual Field Algorithm Using Artificial Scotoma Generation on Human Observers. ( 27622080 )
2016
27
The Effects of Nocturnal Dip and Blood Pressure Variability on Paracentral Scotoma in Early Open-Angle Glaucoma. ( 27128963 )
2016
28
Progressing Scintillating Scotoma Captured on Automated Visual Field Testing. ( 26854039 )
2016
29
Scotoma Visibility and Reading Rate with Bilateral Central Scotomas. ( 28030516 )
2016
30
Clinical Clues to Predict the Presence of Parafoveal Scotoma on Humphrey 10-2 Visual Field Using a Humphrey 24-2 Visual Field. ( 26476213 )
2015
31
Optimal point of fixation to faces for vision with a simulated central scotoma. ( 26326621 )
2015
32
Comparison of Risk Factors for Initial Central Scotoma versus Initial Peripheral Scotoma in Normal-tension Glaucoma. ( 25829826 )
2015
33
Stop before you saccade: Looking into an artificial peripheral scotoma. ( 26067525 )
2015
34
Long-lasting, dense scotoma under light-adapted conditions in patient with multiple evanescent white dot syndrome. ( 26678272 )
2015
35
Microperimetry biofeedback training in a patient with bilateral myopic macular degeneration with central scotoma. ( 26265646 )
2015
36
fMRI of the rod scotoma elucidates cortical rod pathways and implications for lesion measurements. ( 25848028 )
2015
37
Size of the foveal blue scotoma related to the shape of the foveal pit but not to macular pigment. ( 25449158 )
2015
38
Scotoma analysis of 10-2 visual field testing with a red target in screening for hydroxychloroquine retinopathy. ( 26316692 )
2015
39
Scotoma analysis of 10-2 visual field testing with a white target in screening for hydroxychloroquine retinopathy. ( 26060390 )
2015
40
Random word recognition chart helps scotoma assessment in low vision. ( 25946100 )
2015
41
Paracentral scotoma in glaucoma detected by 10-2 but not by 24-2 perimetry. ( 24442888 )
2014
42
Central scotoma and 'muddled thinking' as migraine aura. ( 24045570 )
2014
43
Xanthic scotoma. ( 25256032 )
2014
44
Adaptation to a simulated central scotoma during visual search training. ( 24456805 )
2014
45
Comment on "Central scotoma and 'muddled thinking' as migraine aura" by Daroff. ( 24045572 )
2014
46
Confusion Between Bitemporal Hemianopia and Cecocentral Scotoma. ( 25313789 )
2014
47
Reading with peripheral vision: a comparison of reading dynamic scrolling and static text with a simulated central scotoma. ( 24680772 )
2014
48
Anatomical attributes of the optic nerve head in eyes with parafoveal scotoma in normal tension glaucoma. ( 24595065 )
2014
49
Confusion Between Bitemporal Hemianopia and Cecocentral Scotoma: Reply. ( 25313790 )
2014
50
Parafoveal scotoma progression in glaucoma: humphrey 10-2 versus 24-2 visual field analysis. ( 23697959 )
2013

Variations for Scotoma

Expression for Scotoma

Search GEO for disease gene expression data for Scotoma.

Pathways for Scotoma

Pathways related to Scotoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.36 ABCA4 RDH5

GO Terms for Scotoma

Biological processes related to Scotoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.26 ABCA4 OPA1 RDH5 TRPM1
2 retinoid metabolic process GO:0001523 9.16 ABCA4 RDH5
3 visual perception GO:0007601 8.92 ABCA4 OPA1 RDH5 TRPM1

Sources for Scotoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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