Aliases & Classifications for Scotoma

MalaCards integrated aliases for Scotoma:

Name: Scotoma 12 74 43 15
Generalized Visual Field Contraction or Constriction 12
Sector or Arcuate Visual Field Defects 12
Enlarged Paracaecal Scotoma 12
Scotoma of Blind Spot Area 12
Blind Spot Area Scotoma 12
Enlarged Angioscotoma 12
Enlarged Blind Spot 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9335
ICD9CM 34 368.42 368.44
MeSH 43 D012607
SNOMED-CT 67 33970004
ICD10 32 H53.42 H53.45
UMLS 71 C0029657 C0152192

Summaries for Scotoma

MalaCards based summary : Scotoma, also known as generalized visual field contraction or constriction, is related to optic atrophy 1 and intraocular pressure quantitative trait locus. An important gene associated with Scotoma is ABCA4 (ATP Binding Cassette Subfamily A Member 4), and among its related pathways/superpathways are Phototransduction and Metabolism of fat-soluble vitamins. The drugs Ranibizumab and Verteporfin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and cortex, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 A scotoma is an area of partial alteration in the field of vision consisting of a partially diminished... more...

Related Diseases for Scotoma

Diseases related to Scotoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
# Related Disease Score Top Affiliating Genes
1 optic atrophy 1 32.9 OPA1 DNM1L
2 intraocular pressure quantitative trait locus 31.1 VEGFA OPA1 AQP4
3 cone-rod dystrophy 2 30.9 RPGR RPE65 RHO GUCY2D CYP4V2 CNGB3
4 acute retrobulbar neuritis 30.8 MT-ND4 AQP4
5 neuroretinitis 30.7 RCVRN AQP4
6 optic neuritis 30.7 MT-ND6 MT-ND4 AQP4
7 macular holes 30.7 VEGFA RPE65 KCNMA1
8 macular retinal edema 30.5 VEGFA RHO KCNMA1
9 optic disk drusen 30.5 RHO KCNMA1
10 choroiditis 30.3 VEGFA KCNMA1
11 toxic optic neuropathy 30.2 TMEM126A OPA3 MT-ND6 MT-ND4
12 hydrops, lactic acidosis, and sideroblastic anemia 30.1 VEGFA AQP4
13 retinitis 30.0 RPGR RPE65 RHO EYS ABCA4
14 yemenite deaf-blind hypopigmentation syndrome 29.9 VEGFA RPGR RPE65 RHO GUCY2D ABCA4
15 myopia 29.9 VEGFA RPGR RHO CNGB3
16 optic nerve disease 29.8 VEGFA TMEM126A OPA3 OPA1 MT-ND6 MT-ND4
17 tritanopia 29.6 TMEM126A RHO OPA3 MT-ND4 DNM1L CNGB3
18 macular degeneration, age-related, 1 29.6 VEGFA RPGR RPE65 RHO RCVRN KCNMA1
19 retinal disease 29.3 RPGR RPE65 RHO GUCY2D EYS CNGB3
20 pathologic nystagmus 29.3 RPE65 RHO KCNV2 GUCY2D CNGB3
21 night blindness 29.2 RPGR RPE65 RHO GUCY2D CYP4V2 ABCA4
22 retinal degeneration 28.9 RPGR RPE65 RHO RCVRN GUCY2D CYP4V2
23 leber optic atrophy 28.7 TMEM126A RPE65 OPA3 OPA1 MT-ND6 MT-ND4
24 stargardt disease 28.7 RPGR RPE65 RHO KCNV2 KCNMA1 GUCY2D
25 cone dystrophy 28.6 RPGR RPE65 RHO KCNV2 GUCY2D EYS
26 eye disease 28.4 VEGFA RPGR RPE65 RHO RCVRN MT-ND4
27 retinitis pigmentosa 26.7 VEGFA RPGR RPE65 RHO RCVRN OPA1
28 migraine with or without aura 1 11.5
29 optic atrophy 5 11.3
30 optic atrophy 7 with or without auditory neuropathy 11.3
31 citrullinemia, classic 11.1
32 mohr-tranebjaerg syndrome 11.1
33 birdshot chorioretinopathy 11.1
34 optic atrophy 9 11.1
35 familial hemiplegic migraine 11.1
36 sporadic hemiplegic migraine 11.1
37 deafness, autosomal recessive 59 10.5 TMEM126A OPA1
38 leber optic atrophy and dystonia 10.5 MT-ND6 MT-ND4
39 behr syndrome 10.5 OPA3 OPA1
40 stargardt macular degeneration 10.5 RHO ABCA4
41 solar retinopathy 10.5 RHO ABCA4
42 interval angle-closure glaucoma 10.5 RCVRN ABCA4
43 suppression amblyopia 10.4
44 amblyopia 10.4
45 strabismus 10.4
46 mechanical strabismus 10.4
47 vitreous detachment 10.4 VEGFA KCNMA1
48 neuropathy, hereditary motor and sensory, type via, with optic atrophy 10.4 TMEM126A OPA3
49 neuritis 10.4
50 partial central choroid dystrophy 10.4 GUCY2D ABCA4

Graphical network of the top 20 diseases related to Scotoma:



Diseases related to Scotoma

Symptoms & Phenotypes for Scotoma

GenomeRNAi Phenotypes related to Scotoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.1 GUCY2D
2 Decreased viability GR00221-A-1 10.1 GUCY2D
3 Decreased viability GR00221-A-2 10.1 GUCY2D
4 Decreased viability GR00221-A-3 10.1 GUCY2D
5 Decreased viability GR00221-A-4 10.1 GUCY2D
6 Decreased viability GR00240-S-1 10.1 GUCY2D
7 Decreased viability GR00381-A-1 10.1 DNM1L OPA1
8 Decreased viability GR00402-S-2 10.1 ABCA4 AQP4 CNGB3 CYP4V2 DNM1L EYS
9 no effect GR00402-S-1 9.62 ABCA4 AQP4 CNGB3 CYP4V2 DNM1L EYS

MGI Mouse Phenotypes related to Scotoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 ABCA4 AQP4 CYP4V2 DNM1L GUCY2D KCNV2
2 cardiovascular system MP:0005385 10.02 ABCA4 AQP4 DNM1L KCNMA1 MT-ND6 OPA1
3 nervous system MP:0003631 9.77 ABCA4 AQP4 CNGB3 DNM1L GUCY2D KCNMA1
4 muscle MP:0005369 9.7 DNM1L KCNMA1 MT-ND6 OPA1 OPA3 RPGR
5 vision/eye MP:0005391 9.47 ABCA4 AQP4 CNGB3 CYP4V2 DNM1L GUCY2D

Drugs & Therapeutics for Scotoma

Drugs for Scotoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4 347396-82-1 459903
2
Verteporfin Approved, Investigational Phase 4 129497-78-5
3 Angiogenesis Inhibitors Phase 4
4 Dermatologic Agents Phase 4
5 Photosensitizing Agents Phase 4
6
Latanoprost Approved, Investigational 130209-82-4 5282380 5311221
7
Topiramate Approved 97240-79-4 5284627
8
Nortriptyline Approved 72-69-5 4543
9
Lutein Approved, Investigational, Nutraceutical 127-40-2 6433159
10 Neurotransmitter Agents
11 Hypoglycemic Agents
12 Psychotropic Drugs
13 Anticonvulsants
14 Antidepressive Agents
15 Adrenergic Agents
16 Antidepressive Agents, Tricyclic
17 Omega 3 Fatty Acid

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 A Study to Investigate the Safety and Efficacy of Lucentis (Ranibizumab) in Patients With CNV Due to Causes Other Than AMD and in Patients Where Pigment Epithelial Detachments Are the Primary Manifestation of Their AMD. Completed NCT01628354 Phase 4 Ranibizumab
2 A Prospective Randomized Controlled Multicentre Trial Comparing Half-dose Photodynamic Therapy (PDT) With High-density Subthreshold Micropulse Laser Treatment in Patients With Chronic Central Serous Chorioretinopathy (CSC) Completed NCT01797861 Phase 4
3 Serial Retinal Thickness Changes And Scotoma Size Measured With Lucentis Therapy Measured Using The Optical Coherence Tomography (OCT) Scanning Laser Ophthalmoscope (SLO) And The Foresee Preferential Hyperacuity Perimeter Unknown status NCT01255774 Phase 3 ranibizumab
4 A Phase I/II Study to Evaluate Scotoma Reduction in And Limited Visual Acuity in aGe Related Macular Degeneration Patients Treated With Intravitreal Lucentis Completed NCT00467935 Phase 1, Phase 2 intravitreal injection Lucentis (ranibizumab)
5 Evaluation of Eye Movement Tracking Systems for Visual Rehabilitation Completed NCT00013429 Phase 2
6 Paraorbital-Occipital Alternating Current Stimulation Therapy of Patients With Post-Chiasmatic Lesions Completed NCT01418820 Phase 2
7 Selective Retina Therapy (SRT) in Patients With Idiopathic Central Serous Chorioretinopathy: A Prospective Randomized Controlled Trial Completed NCT00987077 Phase 2
8 Detection of Visual Field Defects and Scotoma Progression in Glaucomatous Optic Neuropathy, Using Short-term Intervals With Automated Scotoma-oriented Perimetry (SCOPE) and the Fast Thresholding Strategy GATE (German Adaptive Threshold Estimation) Unknown status NCT01068938
9 Pilot Study to Compare the Humphrey Field Analyzer (HFA) 30-2 Swedish Interactive Threshold Algorithm (SITA) Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE), Using a New Fast GATE (German Adaptive Threshold Estimation) in Glaucoma Patients Under Topic Therapy Unknown status NCT00902109
10 Observational Prospective Monocentric Study Evaluating "Sweeper" Use During Epiretinal Membrane Surgery Unknown status NCT03350607
11 Manchester Pascal Endpoint Management Laser Treatment of Diffuse Diabetic Macular Oedema (DMO): A Safety and Efficacy Study Unknown status NCT02309476
12 Selective RPE Laser Treatment (SRT) for Various Macular Diseases Unknown status NCT00403884
13 A Study to Develop Both a Novel Method for Evaluating the True Size of a Retinal Object on Fundus Photographs and a New Reaction-time Based Method for Studying the Visual Field on Healthy Volunteers Completed NCT01843582
14 Evaluation of Near Visual Acuity With ODYSIGHT, a Smartphone Based Medical Application in Comparison to a Standardized Method Completed NCT03457441
15 Visuomotor Rehabilitation Training for Manual Task Deficits From Macular Scotomas Completed NCT01691027
16 Detection of Topographic Residual Acuity in Patients With Age Related Macular Degeneration Completed NCT00329277
17 Effectiveness of Training in Reading Rehabilitation for Patients With Diabetic Macular Oedema (DMO)- Randomized Controlled Trial Completed NCT02457884
18 Sparing of the Fovea in Geographic Atrophy Progression Completed NCT02332343
19 Effects of Lutein Supplementation on Macular Pigment Optical Density and Visual Acuity in Patients With Age-related Macular Degeneration Completed NCT00879671
20 Pigment Dispersion Syndrome With and Without Glaucoma Completed NCT00001152
21 Randomized Controlled Clinical Trial to Evaluate the Effects of 577nm Micropulse Laser vs Traditional Laser Therapy on Acute Central Serous Chorioretinopathy Completed NCT02784665
22 Measuring Reading Rehabilitation Outcomes Completed NCT00125632
23 A Multi-Center Study of Reading Rehabilitation in Macular Disease Completed NCT00746668
24 The Use of Transcranial Direct Current Stimulation (TDCS) to Enhance the Rehabilitative Effect of Vision Restoration Therapy Completed NCT00921427 Early Phase 1
25 Head Mounted Eye Tracking Aide for Loss of Central Vision Recruiting NCT02829606
26 Validation of a Smartphone-Based Flicker Fusion Test Recruiting NCT03475147
27 Pilot Study of the Effect on the Retinal Sensitivity of the Membrane Blue Dual® Dye Used for Peeling of the Internal Limiting Membrane in Macular Hole Surgery Recruiting NCT02894424
28 A Prospective Randomized Cross-over Trial of Nortryptyline and Topiramate in the Initial Treatment of Vestibular Migraine. Recruiting NCT02169830 nortriptyline;Topiramate
29 Factors Limiting Peripheral Reading Enrolling by invitation NCT03640130
30 Comparison of Quantitative Metamorphopsia- Measurements in Patients With mCNV Not yet recruiting NCT04112524
31 Assessing Impact of Surgically-induced Deficits on Patient Functioning and Quality of Life (SIND Study) Not yet recruiting NCT04007185
32 Remapping the Visual Field to Aid Reading With Central Scotomas Not yet recruiting NCT03848663
33 Rehabilitation of Visual Function After Brain Injury - Effect of Neuro Vision Technology (NVT) Not yet recruiting NCT03160131
34 Effect of Omega-6:Omega-3 Fatty Acid Ratio on Delaying Progression of Age-related Macular Degeneration (AMD) in Moderate to High Risk Individuals. Terminated NCT00987129

Search NIH Clinical Center for Scotoma

Cochrane evidence based reviews: scotoma

Genetic Tests for Scotoma

Anatomical Context for Scotoma

MalaCards organs/tissues related to Scotoma:

40
Eye, Testes, Cortex, Retina, Pituitary, Brain, Occipital Lobe

Publications for Scotoma

Articles related to Scotoma:

(show top 50) (show all 2149)
# Title Authors PMID Year
1
Solar retinal phototoxicity masquerading as self-inflicted handheld laser-induced lesions. 61
31909293 2020
2
Bilateral retinitis after influenza virus infection in a case report. 61
31956727 2020
3
MULTIMODAL IMAGING IN ACUTE RETINAL NECROSIS PRESENTING WITH MACULAR INVOLVEMENT. 61
32032287 2020
4
Case Report: New-Onset Retinal Migraine After Transseptal Catheterization. 61
31889309 2020
5
Reading in the presence of macular disease: a mini-review. 61
31925832 2020
6
Morpho-Functional Evaluation of Full-Thickness Macular Holes by the Integration of Optical Coherence Tomography Angiography and Microperimetry. 61
31952306 2020
7
[Rhegmatogenous retinal detachment: Topography of breaks and agreement with lincoff's rules]. 61
31761318 2020
8
Multimodal imaging in a young male with osteogenesis imperfecta complicated with choroidal neovascularization. 61
30409043 2020
9
Correlating Adaptive Optics Images to Clinical Findings in Juvenile Macular Dystrophy with Hypotrichosis in Siblings with Homozygous CDH3 Pathogenic Variation. 61
31927556 2020
10
Motion perception in central field loss. 61
31868895 2019
11
17α Estradiol promotes plasticity of spared inputs in the adult amblyopic visual cortex. 61
31836739 2019
12
Predicting artificial visual field losses: A gaze-based inference study. 61
31868896 2019
13
Ocular Syphilis: Clinical Manifestations and Treatment Course. 61
31978289 2019
14
Paediatric migraine with visual hallucination auras appearing in the form of a human body. 61
31796436 2019
15
Perifoveal Exudative Vascular Anomalous Complex With Suspended Scattered Particles in Motion. 61
31877226 2019
16
[Laser membranotomy of acute subhyaloidal hemorrhage after indirect ocular trauma]. 61
30810836 2019
17
Atypical junctional scotoma secondary to optic chiasm atrophy: a case report. 61
30950119 2019
18
MULTIMODAL IMAGING OF A PRESUMED EMBOLIC CILIORETINAL ARTERY OCCLUSION. 61
31725598 2019
19
[Leber's Hereditary Optic Neuropathy]. 61
31639883 2019
20
Leber hereditary optic neuropathy plus dystonia, and transverse myelitis due to double mutations in MT-ND4 and MT-ND6. 61
31776719 2019
21
Cancer-associated Retinopathy with Neuroendocrine Combined Large-cell Lung Carcinoma and Adenocarcinoma. 61
31327819 2019
22
Effect of Visual Feedback on the Eye Position Stability of Patients with AMD. 61
31735860 2019
23
Caecocentral Scotoma: A Rare Presentation of Optic Perineuritis. 61
31886042 2019
24
Spectral-domain optical coherence tomography finding of acute retinal pigment epitheliitis. 61
31942435 2019
25
Bilateral Optic Disc Edema in a Patient with Lead Poisoning. 61
31875108 2019
26
Visual Function at the Atrophic Border in Choroideremia Assessed with Adaptive Optics Microperimetry. 61
31235310 2019
27
Junctional scotoma. A case report. 61
31253509 2019
28
Temporal crescent syndrome vs arcuate scotoma. 61
28318737 2019
29
C-Shaped Scotoma after Complicated Cesarean Section: A Case of Acute Macular Neuroretinopathy. 61
31911780 2019
30
Bilateral Retinopathy and Optic Neuropathy Associated with Systemic Sclerosis. 61
31566453 2019
31
Binocular Inhibition of Reading in Macular Telangiectasia Type 2. 61
31529080 2019
32
A Case of Multi-System Langerhans Cell Histiocytosis with Local Invasion of the Orbital Apex. 61
31762762 2019
33
Odysight: A Mobile Medical Application Designed for Remote Monitoring-A Prospective Study Comparison with Standard Clinical Eye Tests. 61
31346977 2019
34
Management of Deep Retinal Capillary Ischemia by Electromagnetic Stimulation and Platelet-Rich Plasma: Preliminary Clinical Results. 61
31385285 2019
35
Increased Word Spacing Improves Performance for Reading Scrolling Text with Central Vision Loss. 61
31318800 2019
36
Arterial occlusion associated with a prepapillary vascular loop. Anatomical changes on the long term follow up. 61
31153658 2019
37
Sphenoorbital meningioma: a unique skull base tumor. Surgical technique and results. 61
31443076 2019
38
UNUSUAL CAUSE OF BRANCH RETINAL ARTERY OCCLUSION: POLYCYTHEMIA IN A TRANSGENDER MAN FROM UNREGULATED TESTOSTERONE USE. 61
31464822 2019
39
SUCCESSFUL SURGICAL TREATMENT OF MACULA-INVOLVING DEGENERATIVE RETINOSCHISIS BY VITRECTOMY AND DRAINAGE OF THE SCHISIS CAVITY. 61
31453931 2019
40
Reproducibility of Microperimeter 3 (MP-3) Microperimetry in Open-Angle Glaucoma Patients. 61
31430750 2019
41
A case of X-linked retinoschisis with atypical fundus appearance. 61
31006083 2019
42
Performance of a Defect-Mapping Microperimetry Approach for Characterizing Progressive Changes in Deep Scotomas. 61
31388468 2019
43
[Minimal Variant of an Optic Disc Pit with Cecocentral Scotoma Due to Limited Progressive Retinal Ganglion Cell Atrophy - a Case Report]. 61
31266071 2019
44
DIMINUTIVE PARACENTRAL ACUTE MIDDLE MACULOPATHY LESION. 61
31274851 2019
45
MORPHOFUNCTIONAL EVALUATION OF MACULAR-FOVEAL CAPILLARIES: A Comparative Optical Coherence Tomography Angiography and Microperimetry Study. 61
31274711 2019
46
Occipital tip injury with homonymous central scotoma: OCT-NFL and RGC correlation. 61
30766939 2019
47
Impact of simulated micro-scotomas on reading performance in central and peripheral retina. 61
29959926 2019
48
Detailed retinal phenotype of Boucher-Neuhäuser syndrome associated with mutations in PNPLA6 mimicking choroideremia. 61
31135245 2019
49
[Ophthalmological evaluation in children referred to a low-vision rehabilitation project of a social assistance agency]. 61
31344189 2019
50
Fixation instability during binocular viewing in anisometropic and strabismic children. 61
30006273 2019

Variations for Scotoma

Expression for Scotoma

Search GEO for disease gene expression data for Scotoma.

Pathways for Scotoma

GO Terms for Scotoma

Cellular components related to Scotoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.13 TMEM126A RHO PLAAT3 OPA1 MT-ND6 MT-ND4
2 membrane GO:0016020 10.09 VEGFA TMEM126A RPE65 RHO RCVRN PLAAT3
3 mitochondrial membrane GO:0031966 9.56 OPA1 MT-ND6 MT-ND4 DNM1L
4 photoreceptor outer segment GO:0001750 9.17 RPGR RHO RCVRN GUCY2D EYS CNGB3
5 photoreceptor disc membrane GO:0097381 9.13 RHO GUCY2D ABCA4

Biological processes related to Scotoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.7 RPGR RPE65 RHO RCVRN OPA3 OPA1
2 retina development in camera-type eye GO:0060041 9.54 RPE65 RHO OPA1
3 mitochondrial fission GO:0000266 9.46 OPA1 DNM1L
4 retinoid metabolic process GO:0001523 9.46 RPE65 RHO CYP4V2 ABCA4
5 detection of light stimulus involved in visual perception GO:0050908 9.43 RPE65 EYS
6 mitochondrion morphogenesis GO:0070584 9.43 OPA3 OPA1 DNM1L
7 phototransduction, visible light GO:0007603 9.4 RHO ABCA4
8 visual perception GO:0007601 9.36 RPGR RPE65 RHO RCVRN OPA3 OPA1
9 intracellular distribution of mitochondria GO:0048312 9.32 OPA1 DNM1L

Molecular functions related to Scotoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cardiolipin binding GO:1901612 8.62 RPE65 OPA1

Sources for Scotoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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