Aliases & Classifications for Scotoma

MalaCards integrated aliases for Scotoma:

Name: Scotoma 12 75 44 15
Generalized Visual Field Contraction or Constriction 12
Sector or Arcuate Visual Field Defects 12
Enlarged Paracaecal Scotoma 12
Scotoma of Blind Spot Area 12
Blind Spot Area Scotoma 12
Enlarged Angioscotoma 12
Enlarged Blind Spot 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9335
ICD9CM 35 368.42 368.44
MeSH 44 D012607
SNOMED-CT 68 33970004
ICD10 33 H53.42 H53.45
UMLS 72 C0029657 C0152192

Summaries for Scotoma

MalaCards based summary : Scotoma, also known as generalized visual field contraction or constriction, is related to optic atrophy 1 and leber optic atrophy. An important gene associated with Scotoma is MT-ND4 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 4). The drugs Ranibizumab and Verteporfin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and cortex.

Wikipedia : 75 A scotoma is an area of partial alteration in the field of vision consisting of a partially diminished... more...

Related Diseases for Scotoma

Diseases related to Scotoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 optic atrophy 1 32.6 OPA1 DNM1L
2 leber optic atrophy 30.1 MT-ND5 MT-ND4
3 optic nerve disease 29.7 TMEM126A OPA1 MT-ND5 MT-ND4 DNM1L
4 retinitis pigmentosa 28.0 RAX2 MT-ND5 MT-ND4 EYS ABCA4
5 migraine with or without aura 1 11.5
6 cone-rod dystrophy 2 11.3
7 optic atrophy 5 11.3
8 citrullinemia, classic 11.1
9 mohr-tranebjaerg syndrome 11.1
10 birdshot chorioretinopathy 11.1
11 optic atrophy 7 with or without auditory neuropathy 11.1
12 familial hemiplegic migraine 11.1
13 sporadic hemiplegic migraine 11.1
14 macular degeneration, age-related, 1 10.7
15 intraocular pressure quantitative trait locus 10.6
16 suppression amblyopia 10.4
17 amblyopia 10.4
18 strabismus 10.4
19 mechanical strabismus 10.4
20 neuritis 10.4
21 retinal detachment 10.3
22 spastic paraplegia 7, autosomal recessive 10.3 OPA1 MT-ND4
23 yemenite deaf-blind hypopigmentation syndrome 10.3
24 open-angle glaucoma 10.3
25 optic neuritis 10.3
26 macular holes 10.3
27 stargardt disease 10.2
28 myopia 10.2
29 acute retrobulbar neuritis 10.2
30 refractive error 10.2
31 headache 10.2
32 retinitis pigmentosa 19 10.2 KCNMA1 ABCA4
33 glaucoma, primary open angle 10.2
34 neuroretinitis 10.2
35 uveitis 10.2
36 pituitary adenoma 10.2
37 adenoma 10.2
38 pituitary tumors 10.2
39 usher syndrome type 2 10.1 OPA1 EYS
40 deafness, nonsyndromic sensorineural, mitochondrial 10.1 MT-ND5 MT-ND4
41 meningioma, radiation-induced 10.1
42 meningioma, familial 10.1
43 monocular esotropia 10.1
44 spinal meningioma 10.1
45 alternating exotropia 10.1
46 exotropia 10.1
47 retinitis 10.1
48 secretory meningioma 10.1
49 lymphoplasmacyte-rich meningioma 10.1
50 retinal disease 10.1

Graphical network of the top 20 diseases related to Scotoma:



Diseases related to Scotoma

Symptoms & Phenotypes for Scotoma

Drugs & Therapeutics for Scotoma

Drugs for Scotoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4 347396-82-1 459903
2
Verteporfin Approved, Investigational Phase 4 129497-78-5
3 Angiogenesis Inhibitors Phase 4
4 Angiogenesis Modulating Agents Phase 4
5 Dermatologic Agents Phase 4
6 Photosensitizing Agents Phase 4
7
Latanoprost Approved, Investigational 130209-82-4 5282380 5311221
8
Topiramate Approved 97240-79-4 5284627
9
Nortriptyline Approved 72-69-5 4543
10
Lutein Approved, Investigational, Nutraceutical 127-40-2 6433159
11 Immunologic Factors
12 Complement System Proteins
13 Complement Factor H
14 Immunosuppressive Agents
15 Complement Inactivating Agents
16 Neurotransmitter Agents
17 Antidepressive Agents
18 Adrenergic Agents
19 Neurotransmitter Uptake Inhibitors
20 Psychotropic Drugs
21 Anticonvulsants
22 Hypoglycemic Agents
23 Antidepressive Agents, Tricyclic
24 Omega 3 Fatty Acid

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 A Prospective Randomized Controlled Multicentre Trial Comparing Half-dose Photodynamic Therapy (PDT) With High-density Subthreshold Micropulse Laser Treatment in Patients With Chronic Central Serous Chorioretinopathy (CSC) Completed NCT01797861 Phase 4
2 A Study to Investigate the Safety and Efficacy of Lucentis (Ranibizumab) in Patients With CNV Due to Causes Other Than AMD and in Patients Where Pigment Epithelial Detachments Are the Primary Manifestation of Their AMD. Completed NCT01628354 Phase 4 Ranibizumab
3 Serial Retinal Thickness Changes And Scotoma Size Measured With Lucentis Therapy Measured Using The Optical Coherence Tomography (OCT) Scanning Laser Ophthalmoscope (SLO) And The Foresee Preferential Hyperacuity Perimeter Unknown status NCT01255774 Phase 3 ranibizumab
4 A Phase I/II Study to Evaluate Scotoma Reduction in And Limited Visual Acuity in aGe Related Macular Degeneration Patients Treated With Intravitreal Lucentis Completed NCT00467935 Phase 1, Phase 2 intravitreal injection Lucentis (ranibizumab)
5 Evaluation of Eye Movement Tracking Systems for Visual Rehabilitation Completed NCT00013429 Phase 2
6 Paraorbital-Occipital Alternating Current Stimulation Therapy of Patients With Post-Chiasmatic Lesions Completed NCT01418820 Phase 2
7 Selective Retina Therapy (SRT) in Patients With Idiopathic Central Serous Chorioretinopathy: A Prospective Randomized Controlled Trial Completed NCT00987077 Phase 2
8 Detection of Visual Field Defects and Scotoma Progression in Glaucomatous Optic Neuropathy, Using Short-term Intervals With Automated Scotoma-oriented Perimetry (SCOPE) and the Fast Thresholding Strategy GATE (German Adaptive Threshold Estimation) Unknown status NCT01068938
9 Pilot Study to Compare the Humphrey Field Analyzer (HFA) 30-2 Swedish Interactive Threshold Algorithm (SITA) Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE), Using a New Fast GATE (German Adaptive Threshold Estimation) in Glaucoma Patients Under Topic Therapy Unknown status NCT00902109
10 Manchester Pascal Endpoint Management Laser Treatment of Diffuse Diabetic Macular Oedema (DMO): A Safety and Efficacy Study Unknown status NCT02309476
11 Selective RPE Laser Treatment (SRT) for Various Macular Diseases Unknown status NCT00403884
12 Complement Factor H Haplotypes and Smoking in Age-related Macular Degeneration Unknown status NCT01115231
13 A Study to Develop Both a Novel Method for Evaluating the True Size of a Retinal Object on Fundus Photographs and a New Reaction-time Based Method for Studying the Visual Field on Healthy Volunteers Completed NCT01843582
14 Evaluation of Near Visual Acuity With ODYSIGHT, a Smartphone Based Medical Application in Comparison to a Standardized Method Completed NCT03457441
15 Visuomotor Rehabilitation Training for Manual Task Deficits From Macular Scotomas Completed NCT01691027
16 Detection of Topographic Residual Acuity in Patients With Age Related Macular Degeneration Completed NCT00329277
17 Effectiveness of Training in Reading Rehabilitation for Patients With Diabetic Macular Oedema (DMO)- Randomized Controlled Trial Completed NCT02457884
18 Sparing of the Fovea in Geographic Atrophy Progression Completed NCT02332343
19 Effects of Lutein Supplementation on Macular Pigment Optical Density and Visual Acuity in Patients With Age-related Macular Degeneration Completed NCT00879671
20 Pigment Dispersion Syndrome With and Without Glaucoma Completed NCT00001152
21 Randomized Controlled Clinical Trial to Evaluate the Effects of 577nm Micropulse Laser vs Traditional Laser Therapy on Acute Central Serous Chorioretinopathy Completed NCT02784665
22 A Multi-Center Study of Reading Rehabilitation in Macular Disease Completed NCT00746668
23 Measuring Reading Rehabilitation Outcomes Completed NCT00125632
24 The Use of Transcranial Direct Current Stimulation (TDCS) to Enhance the Rehabilitative Effect of Vision Restoration Therapy Completed NCT00921427 Early Phase 1
25 Head Mounted Eye Tracking Aide for Loss of Central Vision Recruiting NCT02829606
26 Validation of a Smartphone-Based Flicker Fusion Test Recruiting NCT03475147
27 New Non-invasive Modalities for Assessing Retinal Structure and Function:Preliminary Investigation Recruiting NCT03475173
28 Pilot Study of the Effect on the Retinal Sensitivity of the Membrane Blue Dual® Dye Used for Peeling of the Internal Limiting Membrane in Macular Hole Surgery Recruiting NCT02894424
29 A Prospective Randomized Cross-over Trial of Nortryptyline and Topiramate in the Initial Treatment of Vestibular Migraine. Recruiting NCT02169830 nortriptyline;Topiramate
30 Factors Limiting Peripheral Reading Enrolling by invitation NCT03640130
31 Observational Prospective Monocentric Study Evaluating "Sweeper" Use During Epiretinal Membrane Surgery Not yet recruiting NCT03350607
32 Assessing Impact of Surgically-induced Deficits on Patient Functioning and Quality of Life (SIND Study) Not yet recruiting NCT04007185
33 Remapping the Visual Field to Aid Reading With Central Scotomas Not yet recruiting NCT03848663
34 Rehabilitation of Visual Function After Brain Injury - Effect of Neuro Vision Technology (NVT) Not yet recruiting NCT03160131
35 Effect of Omega-6:Omega-3 Fatty Acid Ratio on Delaying Progression of Age-related Macular Degeneration (AMD) in Moderate to High Risk Individuals. Terminated NCT00987129

Search NIH Clinical Center for Scotoma

Cochrane evidence based reviews: scotoma

Genetic Tests for Scotoma

Anatomical Context for Scotoma

MalaCards organs/tissues related to Scotoma:

41
Eye, Testes, Cortex, Retina, Brain, Occipital Lobe, Pituitary

Publications for Scotoma

Articles related to Scotoma:

(show top 50) (show all 2114)
# Title Authors PMID Year
1
Odysight: A Mobile Medical Application Designed for Remote Monitoring-A Prospective Study Comparison with Standard Clinical Eye Tests. 38
31346977 2019
2
Management of Deep Retinal Capillary Ischemia by Electromagnetic Stimulation and Platelet-Rich Plasma: Preliminary Clinical Results. 38
31385285 2019
3
Reproducibility of Microperimeter 3 (MP-3) Microperimetry in Open-Angle Glaucoma Patients. 38
31430750 2019
4
A case of X-linked retinoschisis with atypical fundus appearance. 38
31006083 2019
5
Arterial occlusion associated with a prepapillary vascular loop. Anatomical changes on the long term follow up. 38
31153658 2019
6
Increased Word Spacing Improves Performance for Reading Scrolling Text with Central Vision Loss. 38
31318800 2019
7
Cancer-associated Retinopathy with Neuroendocrine Combined Large-cell Lung Carcinoma and Adenocarcinoma: A Case Report. 38
31327819 2019
8
Performance of a Defect-Mapping Microperimetry Approach for Characterizing Progressive Changes in Deep Scotomas. 38
31388468 2019
9
MORPHOFUNCTIONAL EVALUATION OF MACULAR-FOVEAL CAPILLARIES: A Comparative Optical Coherence Tomography Angiography and Microperimetry Study. 38
31274711 2019
10
[Minimal Variant of an Optic Disc Pit with Cecocentral Scotoma Due to Limited Progressive Retinal Ganglion Cell Atrophy - a Case Report]. 38
31266071 2019
11
DIMINUTIVE PARACENTRAL ACUTE MIDDLE MACULOPATHY LESION. 38
31274851 2019
12
Occipital tip injury with homonymous central scotoma: OCT-NFL and RGC correlation. 38
30766939 2019
13
Deep capillary retinal ischemia and high-titer prothrombin-associated antiphospholipid antibodies: A case series of three patients. 38
31011663 2019
14
Detailed retinal phenotype of Boucher-Neuhäuser syndrome associated with mutations in PNPLA6 mimicking choroideremia. 38
31135245 2019
15
[Ophthalmological evaluation in children referred to a low-vision rehabilitation project of a social assistance agency]. 38
31344189 2019
16
Fixation instability during binocular viewing in anisometropic and strabismic children. 38
30006273 2019
17
Junctional scotoma. A case report. 38
31253509 2019
18
Impact of simulated micro-scotomas on reading performance in central and peripheral retina. 38
29959926 2019
19
Plasticity of the human visual brain after an early cortical lesion. 38
29100949 2019
20
Visual Function at the Atrophic Border in Choroideremia Assessed with Adaptive Optics Microperimetry. 38
31235310 2019
21
Clinical features of visual migraine aura: a systematic review. 38
31146673 2019
22
CRAO in Moyamoya Syndrome Associated With Southampton Hemoglobinopathy. 38
31100171 2019
23
Association of Ledipasvir-Sofosbuvir Treatment With Uveitis in Patients Treated for Hepatitis C. 38
30920588 2019
24
Acute unilateral maculopathy associated with adult onset of hand, foot and mouth disease: a case report. 38
31064339 2019
25
Glaucoma progression analysis by Spectral-Domain Optical Coherence Tomography (SD-OCT). 38
30955899 2019
26
Measurement Validity of the Low Vision Independence Measure (LVIM). 38
31120837 2019
27
The contributions of central and peripheral vision to scene-gist recognition with a 180° visual field. 38
31100131 2019
28
Foveal choroidal neovascularization secondary to accidental laser exposure in a dermatologist: A case report. 38
31045804 2019
29
Optical coherence tomography findings in unilateral peripheral cone dysfunction syndrome: a case report. 38
31096954 2019
30
Transplantation of Mature Photoreceptors in Rodents With Retinal Degeneration. 38
31171997 2019
31
[Ocular Syphilis May Lead to Persistent Visual Dysfunction]. 38
30999329 2019
32
RELENTLESS PLACOID CHORIORETINITIS: SUCCESSFUL LONG-TERM TREATMENT WITH INTRAVITREAL TRIAMCINOLONE. 38
28198750 2019
33
Spontaneous Improvement of Visual Acuity in a 13-Year-Old Boy with Neuromyelitis Optica Spectrum Disorder. 38
31312236 2019
34
Atypical junctional scotoma secondary to optic chiasm atrophy: a case report. 38
30950119 2019
35
Humans Trust Central Vision More Than Peripheral Vision Even in the Dark. 38
30905606 2019
36
Organization of area hV5/MT+ in subjects with homonymous visual field defects. 38
29627591 2019
37
OCT angiography features of paracentral acute middle maculopathy. 38
30777975 2019
38
Comparison of Visual Field Progression Rates Among the High Tension Glaucoma, Primary Angle Closure Glaucoma, and Normal Tension Glaucoma. 38
30835290 2019
39
Visual rehabilitation using microperimetric acoustic biofeedback training in individuals with central scotoma. 38
30253443 2019
40
Choroidal Microvascular Dropout in Primary Open-angle Glaucoma Eyes With Disc Hemorrhage. 38
30601223 2019
41
Comparison of pattern electroretinograms of glaucoma patients with parafoveal scotoma versus peripheral nasal step. 38
30837586 2019
42
Choroidal Microvascular Dropout in Primary Angle Closure Glaucoma. 38
30552893 2019
43
Bilateral papillitis and vitritis as the initial ophthalmologic finding in a patient with complex medical history, leading to diagnosis of multisystem sarcoidosis. 38
30627688 2019
44
Coenzyme Q10 treatment improved visual field after homonymous quadrantanopia caused by occipital lobe infarction. 38
30582076 2019
45
Scotoma in psychiatric practice and research. 38
30774064 2019
46
Central Scotoma a Year After Motor Vehicle Crash. 38
30589918 2019
47
SEQUENTIAL CHANGES IN HYDROXYCHLOROQUINE RETINOPATHY UP TO 20 YEARS AFTER STOPPING THE DRUG: Implications for Mild Versus Severe Toxicity. 38
30550532 2019
48
MICROPERIMETRY AS A SCREENING TEST FOR HYDROXYCHLOROQUINE RETINOPATHY: The Hard-Risk-1 Study. 38
30234854 2019
49
Observation of changes after peripheral retinal injury by cosmetic laser, using wide-field scanning laser ophthalmoscope: A case report. 38
30732166 2019
50
[Analysis of Glaucomatous Changes of the Macula Using Optical Coherence Tomography]. 38
30736078 2019

Variations for Scotoma

Expression for Scotoma

Search GEO for disease gene expression data for Scotoma.

Pathways for Scotoma

GO Terms for Scotoma

Cellular components related to Scotoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.65 TMEM126A OPA1 MT-ND5 MT-ND4 DNM1L
2 respiratory chain GO:0070469 9.32 MT-ND5 MT-ND4
3 mitochondrial respiratory chain complex I GO:0005747 9.16 MT-ND5 MT-ND4
4 mitochondrial membrane GO:0031966 9.13 OPA1 MT-ND4 DNM1L
5 mitochondrial inner membrane GO:0005743 8.92 TMEM126A OPA1 MT-ND5 MT-ND4

Biological processes related to Scotoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.76 RAX2 OPA1 EYS ABCA4
2 response to hypoxia GO:0001666 9.61 MT-ND5 MT-ND4 KCNMA1
3 mitochondrial electron transport, NADH to ubiquinone GO:0006120 9.49 MT-ND5 MT-ND4
4 membrane fusion GO:0061025 9.48 OPA1 DNM1L
5 mitochondrion morphogenesis GO:0070584 9.4 OPA1 DNM1L
6 positive regulation of dendritic spine morphogenesis GO:0061003 9.37 OPA1 DNM1L
7 mitochondrial fission GO:0000266 9.32 OPA1 DNM1L
8 intracellular distribution of mitochondria GO:0048312 9.26 OPA1 DNM1L
9 ATP synthesis coupled electron transport GO:0042773 9.16 MT-ND5 MT-ND4
10 visual perception GO:0007601 9.02 RAX2 OPA1 EYS ATXN7 ABCA4
11 dynamin family protein polymerization involved in mitochondrial fission GO:0003374 8.96 OPA1 DNM1L

Molecular functions related to Scotoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADH dehydrogenase (ubiquinone) activity GO:0008137 8.96 MT-ND5 MT-ND4
2 NADH dehydrogenase activity GO:0003954 8.62 MT-ND5 MT-ND4

Sources for Scotoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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