Aliases & Classifications for Scrapie

MalaCards integrated aliases for Scrapie:

Name: Scrapie 12 76 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5434
MeSH 44 D012608
SNOMED-CT 68 35103004
UMLS 73 C0036457

Summaries for Scrapie

MalaCards based summary : Scrapie is related to creutzfeldt-jakob disease and chronic wasting disease. An important gene associated with Scrapie is PRNP (Prion Protein), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Bupivacaine and Anesthetics, Local have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and lymph node, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 76 Scrapie is a fatal, degenerative disease that affects the nervous systems of sheep and goats. It is one... more...

Related Diseases for Scrapie

Diseases related to Scrapie via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 creutzfeldt-jakob disease 31.8 ENO2 MSMB PRND PRNP RPSA SPRN
2 chronic wasting disease 31.1 PRNP SPRN
3 prion disease 30.5 ADAM10 APP ENO2 MAP2 MSMB PRND
4 alzheimer disease 29.3 ADAM10 APP CLU GFAP MAP2 PRNP
5 kuru 11.5
6 encephalopathy 10.8
7 pityriasis rubra pilaris 10.5
8 neuroblastoma 10.5
9 genetic prion diseases 10.3
10 fatal familial insomnia 10.2 MSMB PRNP
11 cerebral hemorrhage 10.2 APP GFAP
12 binswanger's disease 10.2 APP GFAP
13 akinetic mutism 10.2 ENO2 PRNP
14 autoimmune optic neuritis 10.2 APP PRNP
15 intracranial cysts 10.2 ENO2 GFAP
16 primitive neuroectodermal tumor of the cervix uteri 10.2 ENO2 GFAP
17 melanotic medulloblastoma 10.2 ENO2 GFAP
18 cerebellar medulloblastoma 10.2 ENO2 GFAP
19 central nervous system primitive neuroectodermal neoplasm 10.2 ENO2 GFAP
20 clear cell ependymoma 10.1 ENO2 GFAP
21 chiari malformation 10.1 GFAP MAP2
22 gerstmann-straussler disease 10.1 APP MSMB PRNP
23 dysembryoplastic neuroepithelial tumor 10.1 GFAP MAP2
24 plexiform schwannoma 10.1 ENO2 GFAP
25 cerebral neuroblastoma 10.1 ENO2 GFAP
26 subependymal glioma 10.1 ENO2 GFAP
27 astroblastoma 10.1 ENO2 GFAP
28 cerebral ventricle cancer 10.1 ENO2 GFAP
29 microcystic meningioma 10.1 ENO2 GFAP
30 leukoencephalopathy, hereditary diffuse, with spheroids 10.1 APP GFAP PRNP
31 pineal gland cancer 10.1 ENO2 GFAP
32 melanotic neuroectodermal tumor 10.1 ENO2 GFAP
33 benign ependymoma 10.1 ENO2 GFAP
34 pineocytoma 10.1 ENO2 GFAP
35 subependymoma 10.1 ENO2 GFAP
36 benign glioma 10.1 ENO2 GFAP
37 papillary ependymoma 10.1 ENO2 GFAP
38 hemimegalencephaly 10.1 GFAP MAP2
39 central nervous system disease 10.1 APP GFAP PRNP
40 brain ischemia 10.1 GFAP MAP2
41 granular cell tumor 10.1 ENO2 GFAP
42 cystic teratoma 10.1 ENO2 GFAP
43 subependymal giant cell astrocytoma 10.1 ENO2 GFAP
44 central nervous system benign neoplasm 10.1 ENO2 GFAP
45 nervous system benign neoplasm 10.1 ENO2 GFAP
46 traumatic brain injury 10.1 ENO2 GFAP
47 papillary tumor of the pineal region 10.1 ENO2 MAP2
48 leukemia 10.1
49 mastitis 10.1
50 encephalitis 10.1

Graphical network of the top 20 diseases related to Scrapie:



Diseases related to Scrapie

Symptoms & Phenotypes for Scrapie

MGI Mouse Phenotypes related to Scrapie:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.76 APP CLU ENO2 GFAP MAP2 PRND
2 growth/size/body region MP:0005378 9.61 ADAM10 APP ENO2 GFAP MAP2 PRNP
3 nervous system MP:0003631 9.28 ADAM10 APP CLU ENO2 GFAP MAP2

Drugs & Therapeutics for Scrapie

Drugs for Scrapie (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
2 Anesthetics, Local Phase 4
3 Central Nervous System Depressants Phase 4,Not Applicable
4 Peripheral Nervous System Agents Phase 4
5 Anesthetics Phase 4,Not Applicable
6
Ethanol Approved Phase 3 64-17-5 702

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mixture of Liposomal Bupivacaine and Bupivacaine for TAP Block for Open Hysterectomy Recruiting NCT03250507 Phase 4 Bupivacaine;Liposomal bupivacaine;Saline
2 Continues Positive Airway Pressure Treatment for Patients With Dilated Cardiomyopathy and Obstructive Sleep Apnea Recruiting NCT02989181 Phase 3
3 Cohort of Respiratory Failure Patients Treated for the First Time With Non-Invasive Ventilation at Home Recruiting NCT02346305
4 Regional Versus General Anesthesia for Promoting Independence After Hip Fracture Recruiting NCT02507505 Not Applicable

Search NIH Clinical Center for Scrapie

Cochrane evidence based reviews: scrapie

Genetic Tests for Scrapie

Anatomical Context for Scrapie

MalaCards organs/tissues related to Scrapie:

41
Brain, Testes, Lymph Node, Spleen, Retina, Skin, Cerebellum

Publications for Scrapie

Articles related to Scrapie:

(show top 50) (show all 1111)
# Title Authors Year
1
Biodiversity and selection for scrapie resistance in sheep: genetic polymorphism in eight breeds of Algeria. ( 29932065 )
2018
2
Prolonged follicular helper T cell responses in ME7 scrapie-infected mice. ( 29617174 )
2018
3
The effect of genetic susceptibility and targeting of sampling on the sensitivity of the surveillance system and certainty-of-freedom for classical scrapie in Finland in 2008-2014. ( 29559102 )
2018
4
Modelling of strategies for genetic control of scrapie in sheep: The importance of population structure. ( 29584772 )
2018
5
Effects of pH and aggregation in the human prion conversion into scrapie form: a study using molecular dynamics with excited normal modes. ( 29546436 )
2018
6
Dimerization of the cellular prion protein inhibits propagation of scrapie prions. ( 29636413 )
2018
7
Screening of intact yeasts and cell extracts to reduce Scrapie prions during biotransformation of food waste. ( 29422098 )
2018
8
Genetic profile of scrapie codons 146, 211 and 222 in the PRNP gene locus in three breeds of dairy goats. ( 29879210 )
2018
9
Goats singly heterozygous for PRNP S146 or K222 orally inoculated with classical scrapie at birth show no disease at ages well beyond 6 years. ( 29486874 )
2018
10
Predicting the impact of selection for scrapie resistance on PRNP genotype frequencies in goats. ( 29510738 )
2018
11
Cerebrospinal Fluid Prion Disease Biomarkers in Pre-clinical and Clinical Naturally Occurring Scrapie. ( 29572672 )
2018
12
Determining the Relative Susceptibility of Four Prion Protein Genotypes to Atypical Scrapie. ( 29240410 )
2018
13
Decrease of RyR2 in the prion infected cell line and in the brains of the scrapie infected mice models and the patients of human prion diseases. ( 29676187 )
2018
14
Classic and atypical scrapie - a genetic perspective. ( 29887131 )
2018
15
Evolutionary biology and the risk of scrapie disease in sheep. ( 30148080 )
2018
16
Review: Update on Classical and Atypical Scrapie in Sheep and Goats. ( 30200819 )
2018
17
Expression of selected genes isolated from whole blood, liver and obex in lambs with experimental classical scrapie and healthy controls, showing a systemic innate immune response at the clinical end-stage. ( 30208891 )
2018
18
Estimating the impact on food and edible materials of changing scrapie control measures: The scrapie control model. ( 30220396 )
2018
19
Low-volume goat milk transmission of classical scrapie to lambs and goat kids. ( 30235307 )
2018
20
In silico investigation of the prion protein glycosylation profiles in relation to scrapie disease resistance in domestic sheep (Ovis aries). ( 30261281 )
2018
21
Correction to: Biodiversity and selection for scrapie resistance in sheep: genetic polymorphism in eight breeds of Algeria. ( 30262718 )
2018
22
Spatio-temporal and risk factor analysis of alleles related to Scrapie resistance in sheep in Great Britain before, during and after a national breeding program. ( 30314774 )
2018
23
Evaluation and validation of an analytical approach for high-throughput metabolomic fingerprinting using direct introduction-high-resolution mass spectrometry: Applicability to classification of urine of scrapie-infected ewes. ( 30335517 )
2018
24
Prion-like protein gene (PRND) polymorphisms associated with scrapie susceptibility in Korean native black goats. ( 30359416 )
2018
25
Stimulations of the Culture Medium of Activated Microglia and TNF-Alpha on a Scrapie-Infected Cell Line Decrease the Cell Viability and Induce Marked Necroptosis That Also Occurs in the Brains from the Patients of Human Prion Diseases. ( 30399321 )
2018
26
Interspecies transmission to bovinized transgenic mice uncovers new features of a CH1641-like scrapie isolate. ( 30486902 )
2018
27
Selective propagation of mouse-passaged scrapie prions with long incubation period from a mixed prion population using GT1-7 cells. ( 28636656 )
2017
28
Reduction of NF-I_B (p65) in Scrapie-Infected Cultured Cells and in the Brains of Scrapie-Infected Rodents. ( 28783945 )
2017
29
Experimental transmission to a calf of an isolate of Spanish classical scrapie. ( 28920852 )
2017
30
The effect of polymorphisms at codon 146 of the goat PRNP gene on susceptibility to challenge with classical scrapie by different routes. ( 28878088 )
2017
31
Effect of poly-L-arginine in inhibiting scrapie prion protein of cultured cells. ( 28063003 )
2017
32
Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice. ( 29202042 )
2017
33
Case-control study on the use of pituitary-derived hormones from sheep as a potential risk factor for the occurrence of atypical scrapie in Great Britain. ( 28213529 )
2017
34
Ultrastructure and pathology of prion protein amyloid accumulation and cellular damage in extraneural tissues of scrapie-infected transgenic mice expressing anchorless prion protein. ( 28759310 )
2017
35
Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates. ( 28910420 )
2017
36
Quantitating PrP Polymorphisms Present in Prions from Heterozygous Scrapie-Infected Sheep. ( 27936597 )
2017
37
Classical scrapie transmission in ARR/ARR genotype sheep. ( 28721847 )
2017
38
Goats with aspartic acid or serine at codon 146 of the PRNP gene remain scrapie-negative after lifetime exposure in affected herds in Cyprus. ( 27751198 )
2017
39
Codon 141 polymorphisms of the ovine prion protein gene affect the phenotype of classical scrapie transmitted from goats to sheep. ( 28472956 )
2017
40
A novel approach for scrapie-associated prion (PrP(Sc)) detection in blood using the competitive affinity of an aggregate-specific antibody and streptavidin to PrP(Sc). ( 28942337 )
2017
41
Statins are ineffective at reducing neuroinflammation or prolonging survival in scrapie-infected mice. ( 28758631 )
2017
42
Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice. ( 29220360 )
2017
43
Low fraction of the 222K PrP variant in the protease-resistant moiety of PrPres in heterozygous scrapie positive goats. ( 28691895 )
2017
44
Precision in the design of an experimental study deflects the significance of proteinase-activated receptor 2 expression in scrapie-inoculated mice. ( 28613153 )
2017
45
Evidence for more cost-effective surveillance options for bovine spongiform encephalopathy (BSE) and scrapie in Great Britain. ( 28816650 )
2017
46
Correlation of cellular factors and differential scrapie prion permissiveness in ovine microglia. ( 28754560 )
2017
47
Aberrant alterations of the expressions and S-nitrosylation of calmodulin and the downstream factors in the brains of the rodents during scrapie infection. ( 28968141 )
2017
48
Protein misfolding cyclic amplification corroborates the absence of PrP(Sc) accumulation in placenta from foetuses with the ARR/ARQ genotype in natural scrapie. ( 28619160 )
2017
49
Do we need to explain the occurrence of atypical scrapie? ( 28432247 )
2017
50
An in vitro model for assessing effective scrapie decontamination. ( 28757014 )
2017

Variations for Scrapie

Expression for Scrapie

Search GEO for disease gene expression data for Scrapie.

Pathways for Scrapie

Pathways related to Scrapie according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.63 APP CLU ENO2 GFAP MAP2 PRNP
2 10.99 ADAM10 APP MT2A PRNP
3 10.67 APP PRNP
4 10.52 ADAM10 APP

GO Terms for Scrapie

Cellular components related to Scrapie according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.98 APP CLU MSMB PRND SCRG1 SPRN
2 extracellular exosome GO:0070062 9.91 ADAM10 APP CLU ENO2 PRNP RPSA
3 neuronal cell body GO:0043025 9.62 ADAM10 ENO2 MAP2 RPSA
4 anchored component of membrane GO:0031225 9.58 PRND PRNP SPRN
5 dendritic shaft GO:0043198 9.46 APP MAP2
6 cell surface GO:0009986 9.35 ADAM10 APP CLU PRNP TF
7 anchored component of external side of plasma membrane GO:0031362 9.26 PRND PRNP
8 astrocyte projection GO:0097449 9.16 APP GFAP
9 main axon GO:0044304 8.62 APP MAP2

Biological processes related to Scrapie according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.63 APP CLU TF
2 positive regulation of neuron death GO:1901216 9.54 CLU PRNP
3 dendrite development GO:0016358 9.52 APP MAP2
4 cellular response to amyloid-beta GO:1904646 9.51 APP PRNP
5 positive regulation of receptor-mediated endocytosis GO:0048260 9.49 CLU TF
6 regulation of peptidyl-tyrosine phosphorylation GO:0050730 9.48 APP PRNP
7 negative regulation of amyloid-beta formation GO:1902430 9.43 CLU PRNP
8 negative regulation of long-term synaptic potentiation GO:1900272 9.4 APP PRNP
9 neuron projection maintenance GO:1990535 9.37 APP PRNP
10 positive regulation of amyloid-beta formation GO:1902004 9.32 APP CLU
11 modulation of age-related behavioral decline GO:0090647 9.26 APP PRNP
12 positive regulation of amyloid fibril formation GO:1905908 9.16 APP CLU
13 cellular response to copper ion GO:0071280 9.13 APP MT2A PRNP
14 cellular copper ion homeostasis GO:0006878 8.92 APP MT2A PRND PRNP

Sources for Scrapie

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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