Aliases & Classifications for Scrapie

MalaCards integrated aliases for Scrapie:

Name: Scrapie 12 76 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5434
MeSH 44 D012608
SNOMED-CT 68 35103004
UMLS 73 C0036457

Summaries for Scrapie

MalaCards based summary : Scrapie is related to chronic wasting disease and creutzfeldt-jakob disease. An important gene associated with Scrapie is PRNP (Prion Protein), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Bupivacaine and Central Nervous System Depressants have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spleen, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 76 Scrapie is a fatal, degenerative disease that affects the nervous systems of sheep and goats. It is one... more...

Related Diseases for Scrapie

Diseases related to Scrapie via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 chronic wasting disease 31.6 PRNP SPRN
2 creutzfeldt-jakob disease 30.6 ENO2 MSMB PRND PRNP RPSA SPRN
3 alzheimer disease 26.6 ADAM10 APP CLU GFAP MAP2 PRNP
4 prion disease 26.5 ADAM10 APP ENO2 MAP2 MSMB PRND
5 genetic prion diseases 11.3
6 kuru 11.3
7 fatal familial insomnia 10.7 MSMB PRNP
8 encephalopathy 10.7
9 akinetic mutism 10.5 ENO2 PRNP
10 binswanger's disease 10.5 APP GFAP
11 intracranial cysts 10.5 ENO2 GFAP
12 primitive neuroectodermal tumor of the cervix uteri 10.5 ENO2 GFAP
13 melanotic medulloblastoma 10.5 ENO2 GFAP
14 cerebellar medulloblastoma 10.5 ENO2 GFAP
15 central nervous system primitive neuroectodermal neoplasm 10.5 ENO2 GFAP
16 gerstmann-straussler disease 10.5 APP MSMB PRNP
17 subependymal glioma 10.5 ENO2 GFAP
18 cerebral hemorrhage 10.5 APP GFAP PRNP
19 cerebral neuroblastoma 10.5 ENO2 GFAP
20 benign ependymoma 10.5 ENO2 GFAP
21 leukoencephalopathy, hereditary diffuse, with spheroids 10.5 APP GFAP PRNP
22 astroblastoma 10.5 ENO2 GFAP
23 plexiform schwannoma 10.4 ENO2 GFAP
24 cerebral ventricle cancer 10.4 ENO2 GFAP
25 cerebrum cancer 10.4 ENO2 GFAP
26 central nervous system disease 10.4 APP GFAP PRNP
27 pineal gland cancer 10.4 ENO2 GFAP
28 melanotic neuroectodermal tumor 10.4 ENO2 GFAP
29 nervous system disease 10.4 APP GFAP PRNP
30 supratentorial cancer 10.4 ENO2 GFAP
31 pineocytoma 10.4 ENO2 GFAP
32 subependymoma 10.4 ENO2 GFAP
33 microcystic meningioma 10.4 ENO2 GFAP
34 papillary ependymoma 10.4 ENO2 GFAP
35 neuronitis 10.3
36 subependymal giant cell astrocytoma 10.3 ENO2 GFAP
37 granular cell tumor 10.3 ENO2 GFAP
38 angiomatous meningioma 10.3 GFAP TF
39 cystic teratoma 10.2 ENO2 GFAP
40 congenital disorder of glycosylation, type ia 10.2 CLU TF
41 traumatic brain injury 10.2 ENO2 GFAP
42 dysgerminoma of ovary 10.2 ENO2 GFAP
43 medullomyoblastoma 10.1 ENO2 GFAP
44 chiari malformation 10.1 GFAP MAP2
45 dysembryoplastic neuroepithelial tumor 10.1 GFAP MAP2
46 aging 10.1
47 hemimegalencephaly 10.1 GFAP MAP2
48 hydrocephalus 10.0 APP ENO2 GFAP
49 pleomorphic xanthoastrocytoma 10.0 GFAP MAP2
50 neuroblastoma 10.0

Graphical network of the top 20 diseases related to Scrapie:



Diseases related to Scrapie

Symptoms & Phenotypes for Scrapie

MGI Mouse Phenotypes related to Scrapie:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.76 MAP2 PRND PRNP SPRN APP CLU
2 growth/size/body region MP:0005378 9.61 MAP2 PRNP RPSA SPRN TF ADAM10
3 nervous system MP:0003631 9.28 MAP2 PRND PRNP SPRN ADAM10 APP

Drugs & Therapeutics for Scrapie

Drugs for Scrapie (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
2 Central Nervous System Depressants Phase 4,Not Applicable
3 Anesthetics Phase 4,Not Applicable
4 Anesthetics, Local Phase 4
5 Peripheral Nervous System Agents Phase 4
6
Ethanol Approved Phase 3 64-17-5 702

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mixture of Liposomal Bupivacaine and Bupivacaine for TAP Block for Open Hysterectomy Recruiting NCT03250507 Phase 4 Bupivacaine;Liposomal bupivacaine;Saline
2 Continues Positive Airway Pressure Treatment for Patients With Dilated Cardiomyopathy and Obstructive Sleep Apnea Recruiting NCT02989181 Phase 3
3 Cohort of Respiratory Failure Patients Treated for the First Time With Non-Invasive Ventilation at Home Recruiting NCT02346305
4 Regional Versus General Anesthesia for Promoting Independence After Hip Fracture Recruiting NCT02507505 Not Applicable

Search NIH Clinical Center for Scrapie

Cochrane evidence based reviews: scrapie

Genetic Tests for Scrapie

Anatomical Context for Scrapie

MalaCards organs/tissues related to Scrapie:

41
Brain, Testes, Spleen, Lymph Node, Placenta, T Cells, Retina

Publications for Scrapie

Articles related to Scrapie:

(show top 50) (show all 765)
# Title Authors Year
1
Biodiversity and selection for scrapie resistance in sheep: genetic polymorphism in eight breeds of Algeria. ( 29932065 )
2018
2
Prolonged follicular helper T cell responses in ME7 scrapie-infected mice. ( 29617174 )
2018
3
The effect of genetic susceptibility and targeting of sampling on the sensitivity of the surveillance system and certainty-of-freedom for classical scrapie in Finland in 2008-2014. ( 29559102 )
2018
4
Modelling of strategies for genetic control of scrapie in sheep: The importance of population structure. ( 29584772 )
2018
5
Effects of pH and aggregation in the human prion conversion into scrapie form: a study using molecular dynamics with excited normal modes. ( 29546436 )
2018
6
Dimerization of the cellular prion protein inhibits propagation of scrapie prions. ( 29636413 )
2018
7
Screening of intact yeasts and cell extracts to reduce Scrapie prions during biotransformation of food waste. ( 29422098 )
2018
8
Genetic profile of scrapie codons 146, 211 and 222 in the PRNP gene locus in three breeds of dairy goats. ( 29879210 )
2018
9
Goats singly heterozygous for PRNP S146 or K222 orally inoculated with classical scrapie at birth show no disease at ages well beyond 6 years. ( 29486874 )
2018
10
Predicting the impact of selection for scrapie resistance on PRNP genotype frequencies in goats. ( 29510738 )
2018
11
Cerebrospinal Fluid Prion Disease Biomarkers in Pre-clinical and Clinical Naturally Occurring Scrapie. ( 29572672 )
2018
12
Determining the Relative Susceptibility of Four Prion Protein Genotypes to Atypical Scrapie. ( 29240410 )
2018
13
Decrease of RyR2 in the prion infected cell line and in the brains of the scrapie infected mice models and the patients of human prion diseases. ( 29676187 )
2018
14
Classic and atypical scrapie - a genetic perspective. ( 29887131 )
2018
15
Selective propagation of mouse-passaged scrapie prions with long incubation period from a mixed prion population using GT1-7 cells. ( 28636656 )
2017
16
Reduction of NF-I_B (p65) in Scrapie-Infected Cultured Cells and in the Brains of Scrapie-Infected Rodents. ( 28783945 )
2017
17
Experimental transmission to a calf of an isolate of Spanish classical scrapie. ( 28920852 )
2017
18
The effect of polymorphisms at codon 146 of the goat PRNP gene on susceptibility to challenge with classical scrapie by different routes. ( 28878088 )
2017
19
Effect of poly-L-arginine in inhibiting scrapie prion protein of cultured cells. ( 28063003 )
2017
20
Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice. ( 29202042 )
2017
21
Case-control study on the use of pituitary-derived hormones from sheep as a potential risk factor for the occurrence of atypical scrapie in Great Britain. ( 28213529 )
2017
22
Ultrastructure and pathology of prion protein amyloid accumulation and cellular damage in extraneural tissues of scrapie-infected transgenic mice expressing anchorless prion protein. ( 28759310 )
2017
23
Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates. ( 28910420 )
2017
24
Quantitating PrP Polymorphisms Present in Prions from Heterozygous Scrapie-Infected Sheep. ( 27936597 )
2017
25
Classical scrapie transmission in ARR/ARR genotype sheep. ( 28721847 )
2017
26
Goats with aspartic acid or serine at codon 146 of the PRNP gene remain scrapie-negative after lifetime exposure in affected herds in Cyprus. ( 27751198 )
2017
27
Codon 141 polymorphisms of the ovine prion protein gene affect the phenotype of classical scrapie transmitted from goats to sheep. ( 28472956 )
2017
28
A novel approach for scrapie-associated prion (PrP(Sc)) detection in blood using the competitive affinity of an aggregate-specific antibody and streptavidin to PrP(Sc). ( 28942337 )
2017
29
Statins are ineffective at reducing neuroinflammation or prolonging survival in scrapie-infected mice. ( 28758631 )
2017
30
Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice. ( 29220360 )
2017
31
Low fraction of the 222K PrP variant in the protease-resistant moiety of PrPres in heterozygous scrapie positive goats. ( 28691895 )
2017
32
Precision in the design of an experimental study deflects the significance of proteinase-activated receptor 2 expression in scrapie-inoculated mice. ( 28613153 )
2017
33
Evidence for more cost-effective surveillance options for bovine spongiform encephalopathy (BSE) and scrapie in Great Britain. ( 28816650 )
2017
34
Correlation of cellular factors and differential scrapie prion permissiveness in ovine microglia. ( 28754560 )
2017
35
Aberrant alterations of the expressions and S-nitrosylation of calmodulin and the downstream factors in the brains of the rodents during scrapie infection. ( 28968141 )
2017
36
Protein misfolding cyclic amplification corroborates the absence of PrP(Sc) accumulation in placenta from foetuses with the ARR/ARQ genotype in natural scrapie. ( 28619160 )
2017
37
Do we need to explain the occurrence of atypical scrapie? ( 28432247 )
2017
38
An in vitro model for assessing effective scrapie decontamination. ( 28757014 )
2017
39
Scrapie, CWD, and Transmissible Mink Encephalopathy. ( 28838664 )
2017
40
A cross-sectional study of PRNP gene in two native Sicilian goat populations in Italy: a relation between prion gene polymorphisms and scrapie incidence. ( 28674232 )
2017
41
Comparative proteomics analyses for 139A and ME7 scrapie infected mice brains in the middle and terminal stages. ( 27991723 )
2016
42
The part of a long beta hairpin from the scrapie form of the human prion protein is reconstructed in the synthetic CC36 protein. ( 27317933 )
2016
43
Comparison of Two US Sheep Scrapie Isolates Supports Identification as Separate Strains. ( 26936223 )
2016
44
Prion protein genotype survey confirms low frequency of scrapie-resistant K222 allele in British goat herds. ( 26755614 )
2016
45
Classical scrapie prions are associated with peripheral blood monocytes and T-lymphocytes from naturally infected sheep. ( 26847623 )
2016
46
Prion protein scrapie and the normal cellular prion protein. ( 26645475 )
2016
47
Transmission of atypical scrapie to homozygous ARQ sheep. ( 27320968 )
2016
48
Epidemiological investigations on the potential transmissibility of a rare disease: the case of atypical scrapie in Great Britain. ( 26976340 )
2016
49
Application of an in vitro-amplification assay as a novel pre-screening test for compounds inhibiting the aggregation of prion protein scrapie. ( 27385410 )
2016
50
Genetic diversity of the prion protein gene (PRNP) coding sequence in Czech sheep and evaluation of the national breeding programme for resistance to scrapie in the Czech Republic. ( 27215403 )
2016

Variations for Scrapie

Expression for Scrapie

Search GEO for disease gene expression data for Scrapie.

Pathways for Scrapie

Pathways related to Scrapie according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.63 APP CLU ENO2 GFAP MAP2 PRNP
2 10.99 ADAM10 APP MT2A PRNP
3 10.67 APP PRNP
4 10.52 ADAM10 APP

GO Terms for Scrapie

Cellular components related to Scrapie according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.98 APP CLU MSMB PRND SCRG1 SPRN
2 extracellular space GO:0005615 9.8 ADAM10 APP CLU ENO2 MSMB SCRG1
3 anchored component of membrane GO:0031225 9.58 PRND PRNP SPRN
4 cell surface GO:0009986 9.55 ADAM10 APP CLU PRNP TF
5 dendritic shaft GO:0043198 9.46 APP MAP2
6 anchored component of external side of plasma membrane GO:0031362 9.37 PRND PRNP
7 amyloid-beta complex GO:0106003 9.32 CLU PRNP
8 astrocyte projection GO:0097449 8.96 APP GFAP
9 main axon GO:0044304 8.62 APP MAP2

Biological processes related to Scrapie according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.61 APP CLU TF
2 positive regulation of neuron death GO:1901216 9.54 CLU PRNP
3 dendrite development GO:0016358 9.52 APP MAP2
4 cellular response to amyloid-beta GO:1904646 9.51 APP PRNP
5 cellular response to copper ion GO:0071280 9.49 MT2A PRNP
6 positive regulation of receptor-mediated endocytosis GO:0048260 9.48 CLU TF
7 regulation of peptidyl-tyrosine phosphorylation GO:0050730 9.46 APP PRNP
8 positive regulation of amyloid-beta formation GO:1902004 9.4 APP CLU
9 negative regulation of amyloid-beta formation GO:1902430 9.37 CLU PRNP
10 negative regulation of long-term synaptic potentiation GO:1900272 9.32 APP PRNP
11 modulation of age-related behavioral decline GO:0090647 9.26 APP PRNP
12 neuron projection maintenance GO:1990535 9.16 APP PRNP
13 positive regulation of amyloid fibril formation GO:1905908 8.96 APP CLU
14 cellular copper ion homeostasis GO:0006878 8.92 APP MT2A PRND PRNP

Sources for Scrapie

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....