Aliases & Classifications for Scrapie

MalaCards integrated aliases for Scrapie:

Name: Scrapie 12 74 54 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5434
MeSH 43 D012608
UMLS 71 C0036457

Summaries for Scrapie

MalaCards based summary : Scrapie is related to kuru and chronic wasting disease. An important gene associated with Scrapie is SCRG1 (Stimulator Of Chondrogenesis 1), and among its related pathways/superpathways are Neuroscience and Alzheimers Disease. Affiliated tissues include brain, spleen and testes, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 74 Scrapie (/ˈskreɪpi/) is a fatal, degenerative disease affecting the nervous systems of sheep and goats.... more...

Related Diseases for Scrapie

Diseases related to Scrapie via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
# Related Disease Score Top Affiliating Genes
1 kuru 33.0 SPRN PRNP PRND MSMB APP
2 chronic wasting disease 32.6 SPRN RPSA PRNP PRND MSMB GFAP
3 creutzfeldt-jakob disease 31.9 SPRN RPSA PVALB PRNP PRND MSMB
4 prion disease 31.6 SPRN SCRG1 RPSA PRNP PRND MSMB
5 amyloidosis 31.3 PRNP MAPT CLU APP APOE
6 neuroblastoma 31.2 PRNP MAPT MAP2 GFAP ENO2 CDK5
7 fatal familial insomnia 30.9 SPRN PRNP PRND MSMB MAPT APP
8 gerstmann-straussler disease 30.7 SPRN PRNP PRND MSMB MAPT APP
9 central nervous system disease 30.5 PRNP MAPT GFAP APP APOE
10 cerebral amyloid angiopathy, cst3-related 30.3 PRNP MAPT CLU APP APOE
11 down syndrome 30.2 MAPT APP APOE ADAM10
12 leukoencephalopathy, hereditary diffuse, with spheroids 30.1 PVALB PRNP MAPT MAP2 GFAP APP
13 dementia 30.1 PRNP MAPT MAP2 GFAP APP APOE
14 toxic encephalopathy 29.8 PRNP MAPT MAP2 GFAP CDK5 APP
15 alzheimer disease 29.8 PVALB PRNP PRND MAPT MAP2 GFAP
16 pick disease of brain 29.7 PRNP MAPT MAP2 GFAP CLU CDK5
17 amyotrophic lateral sclerosis 1 29.5 PVALB PRNP PRND MAPT MAP2 GFAP
18 encephalopathy 11.3
19 residual stage of open angle glaucoma 10.6 APP APOE
20 senile plaque formation 10.6 APP APOE
21 intracranial cysts 10.6 GFAP ENO2
22 chromosome 17q21.31 duplication syndrome 10.6 MAPT APP
23 posterior cortical atrophy 10.6 MAPT APOE
24 primitive neuroectodermal tumor of the cervix uteri 10.6 GFAP ENO2
25 cerebral neuroblastoma 10.6 GFAP ENO2
26 cerebellopontine angle primitive neuroectodermal tumor 10.6 GFAP ENO2
27 neonatal hypoxic and ischemic brain injury 10.6 PVALB ENO2
28 papillary ependymoma 10.6 GFAP ENO2
29 gerstmann syndrome 10.6 MAPT APOE
30 subependymoma 10.6 GFAP ENO2
31 persistent vegetative state 10.6 ENO2 APOE
32 pineocytoma 10.6 GFAP ENO2
33 simultanagnosia 10.6 MAPT APOE
34 cutaneous ganglioneuroma 10.5 ENO2 APP
35 visual agnosia 10.5 MAPT APOE
36 alzheimer's disease 1 10.5 APP APOE
37 head injury 10.5 ENO2 APOE
38 agraphia 10.5 PRNP MAPT
39 semantic dementia 10.5 MAPT APOE
40 akinetic mutism 10.5 PRNP MAPT ENO2
41 chiari malformation 10.5 MAP2 GFAP
42 papillary tumor of the pineal region 10.5 MAP2 ENO2
43 alzheimer disease 10 10.5 MAPT APOE
44 alzheimer disease 18 10.5 APP ADAM10
45 cerebellar liponeurocytoma 10.5 MAP2 ENO2
46 lipoprotein glomerulopathy 10.5 CLU APOE
47 age-related hearing loss 10.5 MAPT APOE
48 endobronchial leiomyoma 10.5 GFAP ENO2
49 alzheimer disease 2 10.5 MAPT APP APOE
50 nominal aphasia 10.5 MAPT APOE

Graphical network of the top 20 diseases related to Scrapie:



Diseases related to Scrapie

Symptoms & Phenotypes for Scrapie

MGI Mouse Phenotypes related to Scrapie:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.18 APOE APP CAST CDK5 CLU ENO2
2 cardiovascular system MP:0005385 10.02 ADAM10 APOE APP CAST CLU GFAP
3 cellular MP:0005384 10 ADAM10 APOE APP CAST ENO2 FLOT1
4 immune system MP:0005387 9.93 ADAM10 APOE APP CAST CCL21 CLU
5 muscle MP:0005369 9.5 APOE APP CLU GFAP MAPT PRNP
6 nervous system MP:0003631 9.5 ADAM10 APOE APP CAST CDK5 CLU

Drugs & Therapeutics for Scrapie

Search Clinical Trials , NIH Clinical Center for Scrapie

Cochrane evidence based reviews: scrapie

Genetic Tests for Scrapie

Anatomical Context for Scrapie

MalaCards organs/tissues related to Scrapie:

40
Brain, Spleen, Testes, Lymph Node, Retina, Placenta, Spinal Cord

Publications for Scrapie

Articles related to Scrapie:

(show top 50) (show all 4835)
# Title Authors PMID Year
1
Changes of tau profiles in brains of the hamsters infected with scrapie strains 263 K or 139 A possibly associated with the alteration of phosphate kinases. 54 61
20356412 2010
2
A single step multiplex immunofluorometric assay for differential diagnosis of BSE and scrapie. 61 54
20214905 2010
3
Fatal transmissible amyloid encephalopathy: a new type of prion disease associated with lack of prion protein membrane anchoring. 61 54
20221436 2010
4
In vitro amplification of prions from milk in the detection of subclinical infections. 61 54
19949303 2009
5
Genetic analysis of the SPRN gene in ruminants reveals polymorphisms in the alanine-rich segment of shadoo protein. 61 54
19515828 2009
6
Peptide NMHRYPNQ of the cellular prion protein (PrP(C)) inhibits aggregation and is a potential key for understanding prion-prion interactions. 54 61
19607841 2009
7
[Alternations of tau protein and its phosphorylated profiles in the experimental hamsters infected by scrapie agents 263K and 139A]. 54 61
19634763 2009
8
The cellular prion protein and its role in Alzheimer disease. 54 61
19556894 2009
9
Core structure of amyloid fibrils formed by residues 106-126 of the human prion protein. 61 54
19278656 2009
10
Strain-specific viral properties of variant Creutzfeldt-Jakob disease (vCJD) are encoded by the agent and not by host prion protein. 54 61
19097123 2009
11
Dendritic cell-mediated-immunization with xenogenic PrP and adenoviral vectors breaks tolerance and prolongs mice survival against experimental scrapie. 61 54
19295917 2009
12
The role of parvalbumin and calbindin D28k in experimental scrapie. 54 61
18005331 2008
13
Copper-induced structural changes in the ovine prion protein are influenced by a polymorphism at codon 112. 61 54
18280261 2008
14
The elk PRNP codon 132 polymorphism controls cervid and scrapie prion propagation. 54 61
18198392 2008
15
Vaccine approaches to prevent and treat prion infection : progress and challenges. 54 61
18215090 2008
16
Is vaccination against transmissible spongiform encephalopathy feasible? 54 61
17633306 2007
17
Does tetracycline bind helix 2 of prion? An integrated spectroscopical and computational study of the interaction between the antibiotic and alpha helix 2 human prion protein fragments. 54 61
17152078 2007
18
Scrapie infectivity is quickly cleared in tissues of orally-infected farmed fish. 54 61
16776828 2006
19
Retrovirus infection strongly enhances scrapie infectivity release in cell culture. 61 54
16724107 2006
20
Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res. 61 54
16474119 2006
21
Effect of acetylcholinesterase inhibitors on AChE-induced PrP106-126 aggregation. 61 54
17192641 2006
22
An aggregation-specific enzyme-linked immunosorbent assay: detection of conformational differences between recombinant PrP protein dimers and PrP(Sc) aggregates. 61 54
16160162 2005
23
The expression of prion protein (PrP(C)) in the megakaryocyte lineage. 54 61
15946217 2005
24
The role of electrostatic interaction in triggering the unraveling of stable helix 1 in normal prion protein. A molecular dynamics simulation investigation. 61 54
15702928 2005
25
Mucosal vaccination delays or prevents prion infection via an oral route. 61 54
15878645 2005
26
Resistance to scrapie in PrP ARR/ARQ heterozygous sheep is not caused by preferential allelic use. 61 54
15166274 2004
27
Partitioning of TSE infectivity during ethanol fractionation of human plasma. 61 54
15026020 2004
28
Pathology and pathogenesis of bovine spongiform encephalopathy and scrapie. 61 54
15148988 2004
29
Cytosolic prion protein is not toxic and protects against Bax-mediated cell death in human primary neurons. 54 61
12917444 2003
30
Sub-cellular pathology of scrapie: coated pits are increased in PrP codon 136 alanine homozygous scrapie-affected sheep. 61 54
12669239 2003
31
The interplay of glycosylation and disulfide formation influences fibrillization in a prion protein fragment. 54 61
12805563 2003
32
Copper modulation of ion channels of PrP[106-126] mutant prion peptide fragments. 61 54
12879164 2003
33
Susceptibility of transgenic mice expressing chimeric sheep, bovine and human PrP genes to sheep scrapie. 61 54
12679564 2003
34
Scrapie and experimental BSE in sheep. 61 54
14522858 2003
35
Post-translational modifications in prion proteins. 61 54
12470218 2002
36
Overexpressed protein disulfide isomerase in brains of patients with sporadic Creutzfeldt-Jakob disease. 54 61
12453628 2002
37
Exploring the propensities of helices in PrP(C) to form beta sheet using NMR structures and sequence alignments. 54 61
12202354 2002
38
Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein. 54 61
11918972 2002
39
Temporary blockade of the tumor necrosis factor receptor signaling pathway impedes the spread of scrapie to the brain. 54 61
11967328 2002
40
Prion peptide 106-126 as a model for prion replication and neurotoxicity. 61 54
11897566 2002
41
Migrating intestinal dendritic cells transport PrP(Sc) from the gut. 54 61
11752724 2002
42
Antiaggregating antibody raised against human PrP 106-126 recognizes pathological and normal isoforms of the whole prion protein. 54 61
12043842 2001
43
A Yin-Yang role for metals in prion disease. 61 54
11677424 2001
44
Differential diagnosis of infections with the bovine spongiform encephalopathy (BSE) and scrapie agents in sheep. 54 61
11798244 2001
45
Novel differences between two human prion strains revealed by two-dimensional gel electrophoresis. 54 61
11489910 2001
46
The prion gene complex encoding PrP(C) and Doppel: insights from mutational analysis. 54 61
11574147 2001
47
The prion protein has RNA binding and chaperoning properties characteristic of nucleocapsid protein NCP7 of HIV-1. 54 61
11278562 2001
48
Ex vivo propagation of infectious sheep scrapie agent in heterologous epithelial cells expressing ovine prion protein. 61 54
11259656 2001
49
Molecular specificities of antibodies against ovine and murine recombinant prion proteins. 61 54
11178966 2001
50
Cellular prion protein is expressed on peripheral blood mononuclear cells but not platelets of normal and scrapie-infected sheep. 54 61
11224483 2001

Variations for Scrapie

Expression for Scrapie

Search GEO for disease gene expression data for Scrapie.

Pathways for Scrapie

Pathways related to Scrapie according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.86 PRNP MAPT MAP2 GFAP ENO2 CLU
2 11.83 MAPT CDK5 APP APOE ADAM10
3 11.63 MAPT CDK5 APP APOE
4 11.29 PRNP MT2A MAPT APP ADAM10
5
Show member pathways
11.21 CDK5 CAST APP
6 11.01 MAPT CDK5 APP APOE ADAM10

GO Terms for Scrapie

Cellular components related to Scrapie according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 10.34 SPRN RPSA PRNP MT2A MAPT MAP2
2 cytoplasm GO:0005737 10.24 SCRG1 RPSA PVALB PRNP MT2A MAPT
3 extracellular region GO:0005576 10.11 SPRN SCRG1 PRND MSMB MAPT CLU
4 postsynaptic density GO:0014069 9.83 PRNP MAP2 CDK5 ADAM10
5 axon GO:0030424 9.8 PVALB MAPT CDK5 APP ADAM10
6 cell GO:0005623 9.76 PRNP PRND MT2A MAPT CDK5 CCL21
7 membrane raft GO:0045121 9.73 PRNP MAPT FLOT1 APP
8 dendrite GO:0030425 9.73 PRNP MAPT MAP2 CDK5 APOE ADAM10
9 cell body GO:0044297 9.65 MAPT MAP2 GFAP
10 anchored component of external side of plasma membrane GO:0031362 9.57 PRNP PRND
11 Golgi-associated vesicle GO:0005798 9.55 APP ADAM10
12 astrocyte projection GO:0097449 9.54 GFAP APP
13 glial cell projection GO:0097386 9.51 MAPT GFAP
14 nuclear periphery GO:0034399 9.49 MAPT MAP2
15 neurofibrillary tangle GO:0097418 9.32 MAPT CLU
16 neuronal cell body GO:0043025 9.17 PVALB MAPT MAP2 ENO2 CDK5 APOE
17 main axon GO:0044304 9.13 MAPT MAP2 APP

Biological processes related to Scrapie according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein binding GO:0032092 9.74 FLOT1 CDK5 APP
2 axonogenesis GO:0007409 9.73 MAP2 FLOT1 CDK5 APP
3 cellular response to amyloid-beta GO:1904646 9.69 PRNP CDK5 APP
4 microglial cell activation GO:0001774 9.65 MAPT CLU APP
5 neuron projection development GO:0031175 9.65 MAPT MAP2 CDK5 APP APOE
6 cellular response to copper ion GO:0071280 9.63 PRNP MT2A APP
7 reverse cholesterol transport GO:0043691 9.62 CLU APOE
8 astrocyte activation GO:0048143 9.61 MAPT APP
9 positive regulation of T cell migration GO:2000406 9.61 CCL21 APP
10 positive regulation of T cell chemotaxis GO:0010820 9.6 CCL21 ADAM10
11 amyloid fibril formation GO:1990000 9.59 MAPT APP
12 regulation of microtubule polymerization GO:0031113 9.58 MAPT MAP2
13 neuron projection maintenance GO:1990535 9.58 PRNP APP
14 central nervous system neuron development GO:0021954 9.58 MAPT MAP2 CDK5
15 modulation of age-related behavioral decline GO:0090647 9.56 PRNP APP
16 negative regulation of amyloid fibril formation GO:1905907 9.55 CLU APOE
17 regulation of neurotransmitter uptake GO:0051580 9.54 GFAP FLOT1
18 negative regulation of amyloid-beta formation GO:1902430 9.54 PRNP CLU APOE
19 protein import GO:0017038 9.52 CLU APOE
20 negative regulation of long-term synaptic potentiation GO:1900272 9.5 PRNP APP APOE
21 regulation of amyloid-beta clearance GO:1900221 9.49 CLU APOE
22 positive regulation of neuron death GO:1901216 9.46 PRNP MAPT CLU CDK5
23 positive regulation of amyloid fibril formation GO:1905908 9.13 CLU APP APOE
24 cellular copper ion homeostasis GO:0006878 8.92 PRNP PRND MT2A APP

Molecular functions related to Scrapie according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule binding GO:0008017 9.62 PRNP MAPT MAP2 CDK5
2 chaperone binding GO:0051087 9.54 PRNP MAPT CLU
3 amyloid-beta binding GO:0001540 9.43 PRNP CLU APOE
4 lipoprotein particle binding GO:0071813 9.16 MAPT APOE
5 tubulin binding GO:0015631 9.13 PRNP MAPT MAP2
6 tau protein binding GO:0048156 8.92 MAP2 CLU CDK5 APOE

Sources for Scrapie

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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