MCID: SCR016
MIFTS: 37

Scrotal Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Scrotal Carcinoma

MalaCards integrated aliases for Scrotal Carcinoma:

Name: Scrotal Carcinoma 12 15 73
Neoplasm of Scrotum 12 73
Scrotum Neoplasm 12 15
Malignant Neoplasm of Scrotum 73
Malignant Tumour of Scrotum 12
Malignant Scrotal Neoplasm 12
Malignant Tumor of Scrotum 12
Carcinoma of Scrotum 12
Scrotum Cancer 12
Scrotal Tumor 12
Scrotal Ca 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3445 DOID:518
ICD10 33 C63.2
ICD9CM 35 187.7

Summaries for Scrotal Carcinoma

MalaCards based summary : Scrotal Carcinoma, also known as neoplasm of scrotum, is related to scrotum squamous cell carcinoma and scrotum basal cell carcinoma, and has symptoms including pain in scrotum An important gene associated with Scrotal Carcinoma is CDKN2B (Cyclin Dependent Kinase Inhibitor 2B), and among its related pathways/superpathways are MicroRNAs in cancer and HTLV-I infection. The drug Menthol has been mentioned in the context of this disorder. Related phenotypes are Decreased CDKN1A mRNA expression and Decreased CDKN1A mRNA expression

Related Diseases for Scrotal Carcinoma

Diseases related to Scrotal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 scrotum squamous cell carcinoma 11.1
2 scrotum basal cell carcinoma 11.0
3 brain stem astrocytic neoplasm 10.7 CDKN2A TP53
4 atypical neurofibroma 10.7 CDKN2A CDKN2B
5 keratinizing squamous cell carcinoma 10.7 CDKN2A TP53
6 spitz nevus 10.7 CDKN2A TP53
7 bartholin's gland benign neoplasm 10.7 CDKN2A TP53
8 vulva squamous cell carcinoma 10.7 CDKN2A TP53
9 nasal cavity adenocarcinoma 10.7 CDKN2A TP53
10 bone squamous cell carcinoma 10.7 CDKN2A TP53
11 anal squamous cell carcinoma 10.7 CDKN2A TP53
12 glycogen-rich clear cell breast carcinoma 10.7 CDKN2A TP53
13 gastric adenosquamous carcinoma 10.7 CDKN2A TP53
14 ewing's family of tumors 10.7 CDKN2A CDKN2B
15 oral leukoplakia 10.7 CDKN2A TP53
16 anogenital venereal wart 10.7 CDKN2A TP53
17 megaesophagus 10.7 CDKN2A TP53
18 bladder papillary transitional cell neoplasm 10.7 ANO2 TP53
19 cervix uteri carcinoma in situ 10.7 CDKN2A TP53
20 urinary tract papillary transitional cell benign neoplasm 10.7 ANO2 TP53
21 schneiderian carcinoma 10.7 CDKN2A TP53
22 meningeal melanomatosis 10.7 CDKN2A TP53
23 suppressor of tumorigenicity 3 10.7 CDKN2A TP53
24 endocervical adenocarcinoma 10.6 CDKN2A TP53
25 cervix small cell carcinoma 10.6 CDKN2A TP53
26 necrotizing sialometaplasia 10.6 CDKN2A TP53
27 basaloid squamous cell carcinoma 10.6 CDKN2A TP53
28 biliary tract neoplasm 10.6 CDKN2A TP53
29 inverted papilloma 10.6 CDKN2A TP53
30 optic nerve neoplasm 10.6 CDKN2A TP53
31 recessive dystrophic epidermolysis bullosa 10.6 CDKN2A TP53
32 vulva cancer 10.6 CDKN2A TP53
33 squamous cell papilloma 10.6 CDKN2A TP53
34 pre-malignant neoplasm 10.5 CDKN2A TP53
35 juvenile pilocytic astrocytoma 10.5 CDKN2A TP53
36 barrett's adenocarcinoma 10.5 CDKN2A TP53
37 sarcomatoid squamous cell skin carcinoma 10.5 CD68 TP53
38 embryonal sarcoma 10.5 SERPINA3 TP53
39 cervix carcinoma 10.5 CDKN2A TP53
40 lymphohistiocytoid mesothelioma 10.5 CD68 CDKN2A
41 melanomatosis 10.5 CD68 CDKN2A
42 skin squamous cell carcinoma 10.5 CDKN2A TP53
43 cellular schwannoma 10.5 CDKN2A TP53
44 conjunctival degeneration 10.5 CD68 TP53
45 ischemic fasciitis 10.5 CD68 CDKN2A
46 epithelial-myoepithelial carcinoma 10.5 HMGA2 TP53
47 atypical lipomatous tumor 10.5 CDKN2A HMGA2
48 well-differentiated liposarcoma 10.4 CDKN2A HMGA2
49 penile cancer 10.4 CDKN2A TP53
50 skin sarcoma 10.4 CD68 CDKN2B

Graphical network of the top 20 diseases related to Scrotal Carcinoma:



Diseases related to Scrotal Carcinoma

Symptoms & Phenotypes for Scrotal Carcinoma

UMLS symptoms related to Scrotal Carcinoma:


pain in scrotum

GenomeRNAi Phenotypes related to Scrotal Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased CDKN1A mRNA expression GR00389-S-1 9.13 TP53
2 Decreased CDKN1A mRNA expression GR00389-S-2 9.13 HMGA2 TP53
3 Increased TP53 mRNA expression GR00389-S-6 8.62 HMGA2 TP53

MGI Mouse Phenotypes related to Scrotal Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 AFP CDKN2A CDKN2B SMUG1 TP53

Drugs & Therapeutics for Scrotal Carcinoma

Drugs for Scrotal Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved Not Applicable 2216-51-5 16666

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Videoscopic Versus Open Inguinal Lymphadenectomy for Cancer Completed NCT01526486 Not Applicable

Search NIH Clinical Center for Scrotal Carcinoma

Genetic Tests for Scrotal Carcinoma

Anatomical Context for Scrotal Carcinoma

Publications for Scrotal Carcinoma

Articles related to Scrotal Carcinoma:

# Title Authors Year
1
Emergency endovascular management of the common femoral artery rupture due to radiotherapy for scrotal carcinoma. ( 25610613 )
2015
2
A case report of scrotal carcinoma and review of the literature. ( 22949906 )
2012
3
Scrotal carcinoma. ( 21791720 )
2011
4
Scrotal carcinoma: a reminder of a disappearing occupational disease. ( 21686921 )
2009
5
Verrucous scrotal carcinoma in a patient with hypospadias: is there a possible association? ( 12559309 )
2003
6
Dynamic lymphoscintigraphy for staging scrotal carcinoma. ( 11176424 )
2001
7
Verrucous scrotal carcinoma: a radioresponsive tumor. ( 10524907 )
1999
8
Scrotal carcinoma following prolonged use of crude coal tar ointment. ( 2702411 )
1989
9
A population-based study of survival after scrotal carcinoma. ( 3965115 )
1985
10
Scrotal carcinoma in Connecticut metalworkers: sequel to a study of sinonasal cancer. ( 7102658 )
1982

Variations for Scrotal Carcinoma

Expression for Scrotal Carcinoma

Search GEO for disease gene expression data for Scrotal Carcinoma.

Pathways for Scrotal Carcinoma

GO Terms for Scrotal Carcinoma

Cellular components related to Scrotal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 senescence-associated heterochromatin focus GO:0035985 8.62 CDKN2A HMGA2

Biological processes related to Scrotal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell cycle GO:0007049 9.76 CDKN2A CDKN2B HMGA2 TP53
2 cell cycle arrest GO:0007050 9.5 CDKN2A CDKN2B TP53
3 positive regulation of cell cycle arrest GO:0071158 9.43 HMGA2 TP53
4 negative regulation of phosphorylation GO:0042326 9.4 CDKN2A CDKN2B
5 positive regulation of cellular senescence GO:2000774 9.37 CDKN2A HMGA2
6 replicative senescence GO:0090399 9.26 CDKN2A TP53
7 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.16 CDKN2A CDKN2B
8 senescence-associated heterochromatin focus assembly GO:0035986 8.96 CDKN2A HMGA2
9 base-excision repair GO:0006284 8.8 HMGA2 SMUG1 TP53

Molecular functions related to Scrotal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.96 CDKN2A TP53
2 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.62 CDKN2A CDKN2B

Sources for Scrotal Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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