MCID: SCR017
MIFTS: 33

Scrotum Neoplasm

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Scrotum Neoplasm

MalaCards integrated aliases for Scrotum Neoplasm:

Name: Scrotum Neoplasm 12 15
Malignant Tumour of Scrotum 12
Malignant Scrotal Neoplasm 12
Malignant Tumor of Scrotum 12
Neoplasm of Scrotum 12
Scrotum Cancer 12
Scrotal Tumor 12
Scrotal Ca 12

Classifications:



External Ids:

Disease Ontology 12 DOID:518
ICD9CM 36 187.7
NCIt 51 C3560 C4380
SNOMED-CT 69 93999006
ICD10 34 C63.2

Summaries for Scrotum Neoplasm

MalaCards based summary : Scrotum Neoplasm, also known as malignant tumour of scrotum, is related to scrotal carcinoma and paratesticular adenocarcinoma. An important gene associated with Scrotum Neoplasm is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Cellular Senescence (REACTOME) and Pathways in cancer. Related phenotypes are Decreased CDKN1A mRNA expression and Decreased CDKN1A mRNA expression

Related Diseases for Scrotum Neoplasm

Diseases related to Scrotum Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 scrotal carcinoma 30.0 CD68 CDKN2A CDKN2B HMGA2 SERPINA3 TP53
2 paratesticular adenocarcinoma 10.2
3 inflammatory mfh 10.2 CD68 SERPINA3
4 lipoadenoma 10.2 HMGA2 SERPINA3
5 granular cell tumor 10.2 CD68 SERPINA3
6 xanthogranulomatous pyelonephritis 10.2 CD68 SERPINA3
7 reticulohistiocytic granuloma 10.2 CD68 SERPINA3
8 skin sarcoma 10.1 CD68 CDKN2B
9 embryonal sarcoma 10.1 SERPINA3 TP53
10 pleomorphic adenoma 10.1 HMGA2 TP53
11 pleomorphic adenoma carcinoma 10.1 HMGA2 TP53
12 myxosarcoma 10.1 CD68 TP53
13 ulcerative stomatitis 10.1 CD68 TP53
14 epithelial-myoepithelial carcinoma 10.1 HMGA2 TP53
15 pinguecula 10.0 CD68 TP53
16 atypical teratoid rhabdoid tumor 10.0 HMGA2 TP53
17 histiocytoma 10.0 SERPINA3 TP53
18 atypical neurofibroma 10.0 CDKN2A CDKN2B
19 fibrosarcoma of bone 10.0 CDKN2A SERPINA3
20 ewing's family of tumors 10.0 CDKN2A CDKN2B
21 tuberculous epididymitis 10.0
22 dermatofibrosarcoma protuberans 10.0 SERPINA3 TP53
23 myxoid liposarcoma 10.0 HMGA2 TP53
24 lymphohistiocytoid mesothelioma 10.0 CD68 CDKN2A
25 melanomatosis 10.0 CD68 CDKN2A
26 atypical lipomatous tumor 10.0 CDKN2A HMGA2
27 ischemic fasciitis 10.0 CD68 CDKN2A
28 well-differentiated liposarcoma 10.0 CDKN2A HMGA2
29 meningeal melanocytoma 9.9 CD68 CDKN2A
30 central nervous system melanocytic neoplasm 9.9 CD68 CDKN2A
31 acute lymphoblastic leukemia, childhood 9.9 CDKN2A CDKN2B
32 cholecystitis 9.9 CDKN2A TP53
33 nodular tenosynovitis 9.9 CD68 HMGA2 SERPINA3
34 bladder squamous cell carcinoma 9.9 CDKN2A TP53
35 keratinizing squamous cell carcinoma 9.9 CDKN2A TP53
36 spitz nevus 9.9 CDKN2A TP53
37 vulva squamous cell carcinoma 9.9 CDKN2A TP53
38 thyroid lymphoma 9.9 CDKN2A TP53
39 vulvar disease 9.9 CDKN2A TP53
40 nasal cavity adenocarcinoma 9.9 CDKN2A TP53
41 bartholin's gland disease 9.9 CDKN2A TP53
42 anal squamous cell carcinoma 9.9 CDKN2A TP53
43 megaesophagus 9.9 CDKN2A TP53
44 glycogen-rich clear cell breast carcinoma 9.9 CDKN2A TP53
45 gastric adenosquamous carcinoma 9.9 CDKN2A TP53
46 anogenital venereal wart 9.9 CDKN2A TP53
47 cervix uteri carcinoma in situ 9.9 CDKN2A TP53
48 uterus carcinoma in situ 9.9 CDKN2A TP53
49 oral leukoplakia 9.9 CDKN2A TP53
50 meningeal melanomatosis 9.9 CDKN2A TP53

Graphical network of the top 20 diseases related to Scrotum Neoplasm:



Diseases related to Scrotum Neoplasm

Symptoms & Phenotypes for Scrotum Neoplasm

GenomeRNAi Phenotypes related to Scrotum Neoplasm according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased CDKN1A mRNA expression GR00389-S-1 9.13 TP53
2 Decreased CDKN1A mRNA expression GR00389-S-2 9.13 HMGA2 TP53
3 Increased TP53 mRNA expression GR00389-S-6 8.62 HMGA2 TP53

MGI Mouse Phenotypes related to Scrotum Neoplasm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 8.92 CD68 CDKN2A CDKN2B TP53

Drugs & Therapeutics for Scrotum Neoplasm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Videoscopic Versus Open Inguinal Lymphadenectomy for Cancer Completed NCT01526486 Not Applicable

Search NIH Clinical Center for Scrotum Neoplasm

Genetic Tests for Scrotum Neoplasm

Anatomical Context for Scrotum Neoplasm

Publications for Scrotum Neoplasm

Articles related to Scrotum Neoplasm:

# Title Authors Year
1
A Rare Scrotal Tumor: Epididymal Cavernous Hemangioma. ( 30533244 )
2018
2
Epithelioid hemangioma-a rare scrotal tumor of childhood. ( 22698477 )
2012
3
Isolated tuberculous epididymitis presenting as a painless scrotal tumor. ( 22721625 )
2012
4
Tuberculous epididymitis presenting as huge scrotal tumor. ( 18619652 )
2009
5
Human dirofilariasis due to Dirofilaria repens mimicking a scrotal tumor. ( 18384864 )
2009
6
Isolated tuberculous epididymitis masquerading as a scrotal tumor. ( 19255699 )
2008

Variations for Scrotum Neoplasm

Expression for Scrotum Neoplasm

Search GEO for disease gene expression data for Scrotum Neoplasm.

Pathways for Scrotum Neoplasm

Pathways related to Scrotum Neoplasm according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 CDKN2A CDKN2B HMGA2 TP53
2 12.49 CDKN2A CDKN2B TP53
3
Show member pathways
12.39 CDKN2A CDKN2B TP53
4
Show member pathways
12.33 CDKN2A CDKN2B TP53
5
Show member pathways
12.19 CDKN2A CDKN2B TP53
6 12.13 CDKN2A HMGA2 TP53
7 11.95 CDKN2A CDKN2B TP53
8 11.94 CDKN2A CDKN2B TP53
9
Show member pathways
11.89 CDKN2A CDKN2B TP53
10 11.64 CDKN2A CDKN2B TP53
11 11.45 CDKN2A TP53
12 11.44 CDKN2A TP53
13
Show member pathways
11.43 CDKN2A TP53
14 11.34 CDKN2A CDKN2B TP53
15 11.27 CDKN2A TP53
16 11.23 CDKN2A TP53
17 11.17 CDKN2B TP53
18 10.66 CDKN2A TP53
19
Show member pathways
10.6 CDKN2A TP53
20 10.3 CDKN2A CDKN2B TP53

GO Terms for Scrotum Neoplasm

Cellular components related to Scrotum Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 senescence-associated heterochromatin focus GO:0035985 8.62 CDKN2A HMGA2

Biological processes related to Scrotum Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.78 CDKN2A CDKN2B HMGA2 TP53
2 negative regulation of cell proliferation GO:0008285 9.69 CDKN2A CDKN2B TP53
3 positive regulation of gene expression GO:0010628 9.67 CDKN2A HMGA2 TP53
4 positive regulation of apoptotic process GO:0043065 9.63 CDKN2A HMGA2 TP53
5 cell cycle GO:0007049 9.56 CDKN2A CDKN2B HMGA2 TP53
6 Ras protein signal transduction GO:0007265 9.52 CDKN2A TP53
7 base-excision repair GO:0006284 9.43 HMGA2 TP53
8 positive regulation of cell cycle arrest GO:0071158 9.4 HMGA2 TP53
9 negative regulation of phosphorylation GO:0042326 9.37 CDKN2A CDKN2B
10 positive regulation of cellular senescence GO:2000774 9.32 CDKN2A HMGA2
11 replicative senescence GO:0090399 9.16 CDKN2A TP53
12 cell cycle arrest GO:0007050 9.13 CDKN2A CDKN2B TP53
13 senescence-associated heterochromatin focus assembly GO:0035986 8.62 CDKN2A HMGA2

Molecular functions related to Scrotum Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.43 CDKN2A CDKN2B TP53
2 transcription factor binding GO:0008134 9.33 CDKN2A HMGA2 TP53
3 disordered domain specific binding GO:0097718 8.96 CDKN2A TP53
4 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.62 CDKN2A CDKN2B

Sources for Scrotum Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....