Scrotum Squamous Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Scrotum Squamous Cell Carcinoma

MalaCards integrated aliases for Scrotum Squamous Cell Carcinoma:

Name: Scrotum Squamous Cell Carcinoma ¹² ¹⁵

Squamous Cell Carcinoma of Scrotum ⁷¹

Scrotal Squamous Cell Carcinoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:13159

NCIt ⁴⁹ C4643

UMLS ⁷¹ C0349551

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Summaries for Scrotum Squamous Cell Carcinoma

Disease Ontology : ¹² A squamous cell carcinoma that is located in the scrotum.

MalaCards based summary : Scrotum Squamous Cell Carcinoma, also known as squamous cell carcinoma of scrotum, is related to squamous cell carcinoma and anus cancer. An important gene associated with Scrotum Squamous Cell Carcinoma is TARS1 (Threonyl-TRNA Synthetase 1), and among its related pathways/superpathways are Gene Expression and TCR Signaling (Qiagen). Affiliated tissues include scrotum, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Scrotum Squamous Cell Carcinoma

Diseases related to Scrotum Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)

#	Related Disease	Score	Top Affiliating Genes
1	squamous cell carcinoma	10.4
2	anus cancer	10.1	EGFR APOLD1
3	large intestine lipoma	10.1	HHEX APOLD1
4	lipoma of colon	10.1	HHEX APOLD1
5	pustulosis of palm and sole	10.0
6	psoriasis	10.0
7	urethral stricture	10.0
8	rectum adenocarcinoma	10.0	EGFR APOLD1
9	anus disease	9.9	EGFR APOLD1
10	bile duct cystadenoma	9.7	CHEK2 ATM
11	lig4 syndrome	9.6	H2AX ATM
12	t-cell prolymphocytic leukemia	9.6	CHEK2 ATM
13	proctitis	9.6	ATM APOLD1
14	breast adenocarcinoma	9.5	MAPK3 EGFR CHEK2
15	bilateral breast cancer	9.5	CHEK2 ATM
16	suppression of tumorigenicity 12	9.4	MAPK3 EGFR ATM
17	li-fraumeni syndrome	9.4	EGFR CHEK2 ATM
18	cowden syndrome	9.4	EGFR CHEK2 ATM
19	melanoma, cutaneous malignant 1	9.4	EGFR CHEK2 ATM
20	nijmegen breakage syndrome	9.3	H2AX CHEK2 ATM
21	autosomal recessive cerebellar ataxia	9.3	H2AX CHEK2 ATM
22	ovarian disease	9.3	EGFR CHEK2 ATM
23	seckel syndrome	9.3	H2AX CHEK2 ATM
24	ataxia-telangiectasia	9.3	H2AX CHEK2 ATM
25	lynch syndrome	9.2	EGFR CHEK2 ATM
26	telangiectasis	9.2	CHEK2 ATM
27	adenoid cystic carcinoma	9.0	EGFR CHEK2 ATM
28	sporadic breast cancer	9.0	H2AX EGFR CHEK2 ATM
29	glioblastoma multiforme	8.9	MAPK3 EGFR CHEK2 ATM
30	myelodysplastic syndrome	8.8	MAPK3 H2AX CHEK2 ATM
31	leukemia, acute myeloid	8.6	MAPK3 H2AX EGFR CHEK2 ATM
32	retinitis pigmentosa	8.5	PDE6B MAPK3 HHEX H2AX EGFR ATM

Graphical network of the top 20 diseases related to Scrotum Squamous Cell Carcinoma:

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Symptoms & Phenotypes for Scrotum Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Scrotum Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

²⁶ (show all 13)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-2	10	EGFR
2	Decreased viability	GR00221-A-1	10	EGFR
3	Decreased viability	GR00221-A-2	10	CHEK2
4	Decreased viability	GR00221-A-3	10	ATM CHEK2
5	Decreased viability	GR00221-A-4	10	ATM CHEK2 EGFR MAPK3
6	Decreased viability	GR00342-S-2	10	CHEK2
7	Decreased viability	GR00402-S-2	10	ATM CHEK2 EGFR MAPK3
8	Decreased substrate adherent cell growth	GR00193-A-1	9.65	MAPK3
9	Decreased substrate adherent cell growth	GR00193-A-2	9.65	ATM EGFR MAPK3
10	Decreased substrate adherent cell growth	GR00193-A-3	9.65	MAPK3
11	Decreased viability with paclitaxel	GR00179-A-1	9.56	EGFR MAPK3
12	Decreased viability with paclitaxel	GR00179-A-3	9.56	EGFR MAPK3
13	Increased viability with MLN4924 (a NAE inhibitor)	GR00250-A-3	8.92	ATM CHEK2 H2AX MAPK3

MGI Mouse Phenotypes related to Scrotum Squamous Cell Carcinoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.8	ATM CHEK2 EGFR H2AX HHEX MAPK3
2	endocrine/exocrine gland	MP:0005379	9.63	ATM CHEK2 EGFR H2AX HHEX MAPK3
3	hematopoietic system	MP:0005397	9.5	ATM CHEK2 EGFR H2AX HHEX MAPK3
4	neoplasm	MP:0002006	9.02	ATM CHEK2 EGFR H2AX MAPK3

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Drugs & Therapeutics for Scrotum Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Scrotum Squamous Cell Carcinoma

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Genetic Tests for Scrotum Squamous Cell Carcinoma

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Anatomical Context for Scrotum Squamous Cell Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Scrotum Squamous Cell Carcinoma:

¹⁹

Scrotum

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Publications for Scrotum Squamous Cell Carcinoma

Articles related to Scrotum Squamous Cell Carcinoma:

#	Title	Authors	PMID	Year
1	Squamous cell carcinoma of scrotum mimicking as scrotal abscess. ⁶¹	Garg G...Sankhwar S	29982190	2018
2	Unusual squamous cell carcinoma of the scrotum arising from a well healed, innocuous scar of an infertility procedure: a case report. ⁶¹	Kotwal S...Whelan P	17688712	2007
3	Squamous cell carcinoma of scrotum. ⁶¹	Lowe FC	3966286	1985

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Genes for Scrotum Squamous Cell Carcinoma

Genes related to Scrotum Squamous Cell Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TARS1	Threonyl-TRNA Synthetase 1	Protein Coding	5.2	DISEASES inferred ¹⁵
2	PDE6B	Phosphodiesterase 6B	Protein Coding	4.67	DISEASES inferred ¹⁵
3	EGFR	Epidermal Growth Factor Receptor	Protein Coding	4.37	DISEASES inferred ¹⁵
4	HHEX	Hematopoietically Expressed Homeobox	Protein Coding	4.29	DISEASES inferred ¹⁵
5	APOLD1	Apolipoprotein L Domain Containing 1	Protein Coding	4.03	DISEASES inferred ¹⁵
6	H2AX	H2A.X Variant Histone	Protein Coding	3.91	DISEASES inferred ¹⁵
7	CHEK2	Checkpoint Kinase 2	Protein Coding	3.85	DISEASES inferred ¹⁵
8	ATM	ATM Serine/Threonine Kinase	Protein Coding	3.39	DISEASES inferred ¹⁵
9	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	3.32	DISEASES inferred ¹⁵

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Variations for Scrotum Squamous Cell Carcinoma

Cosmic variations for Scrotum Squamous Cell Carcinoma:

⁹

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM92933808	RBM10	skin,scrotum,carcinoma,squamous cell carcinoma	c.502C>T	p.R168W	23:47171133-47171133	0

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Expression for Scrotum Squamous Cell Carcinoma

Search GEO for disease gene expression data for Scrotum Squamous Cell Carcinoma.

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Pathways for Scrotum Squamous Cell Carcinoma

Pathways related to Scrotum Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 24)

#	Super pathways	Score	Top Affiliating Genes
1	Gene Expression ⁶⁵ Show member pathways Generic Transcription Pathway ⁶⁵	13.48	TARS1 MAPK3 H2AX EGFR CHEK2 ATM
2	TCR Signaling (Qiagen) ⁶³ Show member pathways ITK and TCR Signaling ⁶³ PDGF Pathway ⁶³ PKC-Theta Pathway ⁶³ TCR Signaling ⁶³	12.57	MAPK3 H2AX CHEK2 ATM
3	MicroRNAs in cancer ³⁶	12.28	MAPK3 EGFR ATM
4	DNA Damage ⁴	12.25	H2AX CHEK2 ATM
5	Apoptosis Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ NF-kappaB Pathway ⁷⁰	12.16	EGFR CHEK2 ATM
6	Shigellosis ³⁶	12.1	MAPK3 EGFR ATM
7	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁶	12.08	H2AX CHEK2 ATM
8	DNA Double Strand Break Response ⁶⁵ Show member pathways Nonhomologous End-Joining (NHEJ) ⁶⁵ Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ⁶⁵ Sensing of DNA Double Strand Breaks ⁶⁵	12.06	H2AX CHEK2 ATM
9	Human T-cell leukemia virus 1 infection ³⁶	12.03	MAPK3 CHEK2 ATM
10	Cellular senescence (KEGG) ³⁶	11.81	MAPK3 CHEK2 ATM
11	Integrated Breast Cancer Pathway ¹	11.77	EGFR CHEK2 ATM
12	UVA-Induced MAPK Signaling ⁶³ Show member pathways UVB-Induced MAPK Signaling ⁶³	11.64	MAPK3 EGFR ATM
13	FoxO signaling pathway ³⁶ Show member pathways PLK2 and PLK4 events ¹ Polo-like kinase signaling events in the cell cycle ¹	11.63	MAPK3 EGFR ATM
14	ATM Pathway ⁶³ Show member pathways ATM Signaling Pathway ¹	11.37	H2AX CHEK2 ATM
15	miRNAs involved in DNA damage response ¹	11.31	H2AX ATM
16	Integrated Cancer Pathway ¹	11.26	CHEK2 ATM
17	Cell cycle Role of 14-3-3 proteins in cell cycle regulation ²² Show member pathways 14-3-3 and Cell Cycle Regulation ⁶³	11.24	CHEK2 ATM
18	DNA damage_ATM/ATR regulation of G1/S checkpoint ²²	11.23	CHEK2 ATM
19	Vemurafenib Pathway, Pharmacodynamics ⁶⁰	11.21	MAPK3 EGFR
20	Regulation of Telomerase ¹	11.15	MAPK3 EGFR ATM
21	EGF receptor (ErbB1) signaling pathway ¹	10.88	MAPK3 EGFR
22	ATM Signaling Network in Development and Disease ¹	10.79	H2AX CHEK2 ATM
23	Signal transduction by L1 ⁶⁵	10.78	MAPK3 EGFR
24	Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.16	H2AX CHEK2 ATM

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GO Terms for Scrotum Squamous Cell Carcinoma

Cellular components related to Scrotum Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromosome, telomeric region	GO:0000781	8.8	H2AX CHEK2 ATM

Biological processes related to Scrotum Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 22)

#	Name	GO ID	Score	Top Affiliating Genes
1	phosphorylation	GO:0016310	9.84	MAPK3 EGFR CHEK2 ATM
2	cell cycle	GO:0007049	9.81	MAPK3 H2AX CHEK2 ATM
3	protein phosphorylation	GO:0006468	9.8	MAPK3 EGFR CHEK2 ATM
4	cellular response to DNA damage stimulus	GO:0006974	9.67	MAPK3 H2AX CHEK2 ATM
5	positive regulation of protein phosphorylation	GO:0001934	9.65	MAPK3 EGFR CHEK2
6	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.61	CHEK2 ATM
7	protein autophosphorylation	GO:0046777	9.61	EGFR CHEK2 ATM
8	thymus development	GO:0048538	9.6	MAPK3 ATM
9	activation of MAPKK activity	GO:0000186	9.59	MAPK3 EGFR
10	response to ionizing radiation	GO:0010212	9.58	H2AX ATM
11	cellular response to reactive oxygen species	GO:0034614	9.58	MAPK3 EGFR
12	peptidyl-serine phosphorylation	GO:0018105	9.58	MAPK3 CHEK2 ATM
13	cellular response to cadmium ion	GO:0071276	9.57	MAPK3 EGFR
14	positive regulation of DNA repair	GO:0045739	9.56	H2AX EGFR
15	positive regulation of telomere maintenance via telomerase	GO:0032212	9.55	MAPK3 ATM
16	peptidyl-tyrosine autophosphorylation	GO:0038083	9.52	MAPK3 EGFR
17	regulation of phosphatidylinositol 3-kinase signaling	GO:0014066	9.46	MAPK3 EGFR
18	DNA damage checkpoint	GO:0000077	9.33	H2AX CHEK2 ATM
19	replicative senescence	GO:0090399	9.32	CHEK2 ATM
20	positive regulation of histone phosphorylation	GO:0033129	9.26	MAPK3 ATM
21	cellular response to gamma radiation	GO:0071480	9.13	H2AX CHEK2 ATM
22	DNA damage induced protein phosphorylation	GO:0006975	8.8	MAPK3 CHEK2 ATM

Molecular functions related to Scrotum Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ATP binding	GO:0005524	9.65	TARS1 MAPK3 EGFR CHEK2 ATM
2	kinase activity	GO:0016301	9.46	MAPK3 EGFR CHEK2 ATM
3	protein kinase activity	GO:0004672	9.26	MAPK3 EGFR CHEK2 ATM
4	nucleotide binding	GO:0000166	9.02	TARS1 MAPK3 EGFR CHEK2 ATM

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Sources for Scrotum Squamous Cell Carcinoma

¹ BioSystems

² BitterDB

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²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³² ICD10

³³ ICD10 via Orphanet

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³⁵ IUPHAR

³⁶ KEGG

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⁴⁰ MalaCards

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⁴⁷ NCBI Bookshelf

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⁵¹ NIH Clinical Center

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⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

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⁶¹ PubMed

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⁶⁹ TGDB

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⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia