MCID: SCR013
MIFTS: 30

Scrotum Squamous Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Scrotum Squamous Cell Carcinoma

MalaCards integrated aliases for Scrotum Squamous Cell Carcinoma:

Name: Scrotum Squamous Cell Carcinoma 12 15
Squamous Cell Carcinoma of Scrotum 71
Scrotal Squamous Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13159
NCIt 49 C4643
UMLS 71 C0349551

Summaries for Scrotum Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is located in the scrotum.

MalaCards based summary : Scrotum Squamous Cell Carcinoma, also known as squamous cell carcinoma of scrotum, is related to squamous cell carcinoma and anus cancer. An important gene associated with Scrotum Squamous Cell Carcinoma is TARS1 (Threonyl-TRNA Synthetase 1), and among its related pathways/superpathways are Gene Expression and TCR Signaling (Qiagen). Affiliated tissues include scrotum, breast and colon, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Scrotum Squamous Cell Carcinoma

Diseases related to Scrotum Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 34, show less)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 10.4
2 anus cancer 10.1 EGFR APOLD1
3 large intestine lipoma 10.1 HHEX APOLD1
4 lipoma of colon 10.1 HHEX APOLD1
5 keratosis 10.0
6 pustulosis of palm and sole 10.0
7 psoriasis 10.0
8 urethral stricture 10.0
9 rectum adenocarcinoma 10.0 EGFR APOLD1
10 anus disease 9.9 EGFR APOLD1
11 bile duct cystadenoma 9.7 CHEK2 ATM
12 lig4 syndrome 9.6 H2AX ATM
13 t-cell prolymphocytic leukemia 9.6 CHEK2 ATM
14 proctitis 9.6 ATM APOLD1
15 breast adenocarcinoma 9.5 MAPK3 EGFR CHEK2
16 bilateral breast cancer 9.5 CHEK2 ATM
17 suppression of tumorigenicity 12 9.4 MAPK3 EGFR ATM
18 li-fraumeni syndrome 9.4 EGFR CHEK2 ATM
19 cowden syndrome 9.4 EGFR CHEK2 ATM
20 melanoma, cutaneous malignant 1 9.4 EGFR CHEK2 ATM
21 nijmegen breakage syndrome 9.3 H2AX CHEK2 ATM
22 autosomal recessive cerebellar ataxia 9.3 H2AX CHEK2 ATM
23 ovarian disease 9.3 EGFR CHEK2 ATM
24 seckel syndrome 9.3 H2AX CHEK2 ATM
25 ataxia-telangiectasia 9.3 H2AX CHEK2 ATM
26 lynch syndrome 9.2 EGFR CHEK2 ATM
27 telangiectasis 9.2 CHEK2 ATM
28 trichothiodystrophy 1, photosensitive 9.0 TARS1 H2AX CHEK2 ATM
29 adenoid cystic carcinoma 9.0 EGFR CHEK2 ATM
30 sporadic breast cancer 9.0 H2AX EGFR CHEK2 ATM
31 glioblastoma multiforme 8.9 MAPK3 EGFR CHEK2 ATM
32 myelodysplastic syndrome 8.8 MAPK3 H2AX CHEK2 ATM
33 leukemia, acute myeloid 8.6 MAPK3 H2AX EGFR CHEK2 ATM
34 retinitis pigmentosa 8.5 PDE6B MAPK3 HHEX H2AX EGFR ATM

Graphical network of the top 20 diseases related to Scrotum Squamous Cell Carcinoma:



Diseases related to Scrotum Squamous Cell Carcinoma

Symptoms & Phenotypes for Scrotum Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Scrotum Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26 (showing 13, show less)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10 EGFR
2 Decreased viability GR00221-A-1 10 EGFR
3 Decreased viability GR00221-A-2 10 CHEK2
4 Decreased viability GR00221-A-3 10 ATM CHEK2
5 Decreased viability GR00221-A-4 10 ATM CHEK2 EGFR MAPK3
6 Decreased viability GR00342-S-2 10 CHEK2
7 Decreased viability GR00402-S-2 10 ATM CHEK2 EGFR MAPK3
8 Decreased substrate adherent cell growth GR00193-A-1 9.65 MAPK3
9 Decreased substrate adherent cell growth GR00193-A-2 9.65 ATM EGFR MAPK3
10 Decreased substrate adherent cell growth GR00193-A-3 9.65 MAPK3
11 Decreased viability with paclitaxel GR00179-A-1 9.56 EGFR MAPK3
12 Decreased viability with paclitaxel GR00179-A-3 9.56 EGFR MAPK3
13 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.92 ATM CHEK2 H2AX MAPK3

MGI Mouse Phenotypes related to Scrotum Squamous Cell Carcinoma:

45 (showing 4, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 ATM CHEK2 EGFR H2AX HHEX MAPK3
2 endocrine/exocrine gland MP:0005379 9.63 ATM CHEK2 EGFR H2AX HHEX MAPK3
3 hematopoietic system MP:0005397 9.5 ATM CHEK2 EGFR H2AX HHEX MAPK3
4 neoplasm MP:0002006 9.02 ATM CHEK2 EGFR H2AX MAPK3

Drugs & Therapeutics for Scrotum Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Scrotum Squamous Cell Carcinoma

Genetic Tests for Scrotum Squamous Cell Carcinoma

Anatomical Context for Scrotum Squamous Cell Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Scrotum Squamous Cell Carcinoma:

19
Scrotum

MalaCards organs/tissues related to Scrotum Squamous Cell Carcinoma:

40
Breast, Colon, Myeloid, T Cells

Publications for Scrotum Squamous Cell Carcinoma

Articles related to Scrotum Squamous Cell Carcinoma:

(showing 3, show less)
# Title Authors PMID Year
1
Squamous cell carcinoma of scrotum mimicking as scrotal abscess. 61
29982190 2018
2
Unusual squamous cell carcinoma of the scrotum arising from a well healed, innocuous scar of an infertility procedure: a case report. 61
17688712 2007
3
Squamous cell carcinoma of scrotum. 61
3966286 1985

Variations for Scrotum Squamous Cell Carcinoma

Cosmic variations for Scrotum Squamous Cell Carcinoma:

9 (showing 1, show less)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM92933808 RBM10 skin,scrotum,carcinoma,squamous cell carcinoma c.502C>T p.R168W 23:47171133-47171133 0

Expression for Scrotum Squamous Cell Carcinoma

Search GEO for disease gene expression data for Scrotum Squamous Cell Carcinoma.

Pathways for Scrotum Squamous Cell Carcinoma

Pathways related to Scrotum Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(showing 24, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.48 TARS1 MAPK3 H2AX EGFR CHEK2 ATM
2
Show member pathways
12.57 MAPK3 H2AX CHEK2 ATM
3 12.28 MAPK3 EGFR ATM
4 12.25 H2AX CHEK2 ATM
5
Show member pathways
12.16 EGFR CHEK2 ATM
6 12.1 MAPK3 EGFR ATM
7
Show member pathways
12.08 H2AX CHEK2 ATM
8
Show member pathways
12.06 H2AX CHEK2 ATM
9 12.03 MAPK3 CHEK2 ATM
10 11.81 MAPK3 CHEK2 ATM
11 11.77 EGFR CHEK2 ATM
12
Show member pathways
11.64 MAPK3 EGFR ATM
13
Show member pathways
11.63 MAPK3 EGFR ATM
14
Show member pathways
11.37 H2AX CHEK2 ATM
15 11.31 H2AX ATM
16 11.26 CHEK2 ATM
17
Show member pathways
11.24 CHEK2 ATM
18 11.23 CHEK2 ATM
19 11.21 MAPK3 EGFR
20 11.15 MAPK3 EGFR ATM
21 10.88 MAPK3 EGFR
22 10.79 H2AX CHEK2 ATM
23 10.78 MAPK3 EGFR
24 10.16 H2AX CHEK2 ATM

GO Terms for Scrotum Squamous Cell Carcinoma

Cellular components related to Scrotum Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 chromosome, telomeric region GO:0000781 8.8 H2AX CHEK2 ATM

Biological processes related to Scrotum Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(showing 22, show less)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.84 MAPK3 EGFR CHEK2 ATM
2 cell cycle GO:0007049 9.81 MAPK3 H2AX CHEK2 ATM
3 protein phosphorylation GO:0006468 9.8 MAPK3 EGFR CHEK2 ATM
4 cellular response to DNA damage stimulus GO:0006974 9.67 MAPK3 H2AX CHEK2 ATM
5 positive regulation of protein phosphorylation GO:0001934 9.65 MAPK3 EGFR CHEK2
6 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.61 CHEK2 ATM
7 protein autophosphorylation GO:0046777 9.61 EGFR CHEK2 ATM
8 thymus development GO:0048538 9.6 MAPK3 ATM
9 activation of MAPKK activity GO:0000186 9.59 MAPK3 EGFR
10 response to ionizing radiation GO:0010212 9.58 H2AX ATM
11 cellular response to reactive oxygen species GO:0034614 9.58 MAPK3 EGFR
12 peptidyl-serine phosphorylation GO:0018105 9.58 MAPK3 CHEK2 ATM
13 cellular response to cadmium ion GO:0071276 9.57 MAPK3 EGFR
14 positive regulation of DNA repair GO:0045739 9.56 H2AX EGFR
15 positive regulation of telomere maintenance via telomerase GO:0032212 9.55 MAPK3 ATM
16 peptidyl-tyrosine autophosphorylation GO:0038083 9.52 MAPK3 EGFR
17 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.46 MAPK3 EGFR
18 DNA damage checkpoint GO:0000077 9.33 H2AX CHEK2 ATM
19 replicative senescence GO:0090399 9.32 CHEK2 ATM
20 positive regulation of histone phosphorylation GO:0033129 9.26 MAPK3 ATM
21 cellular response to gamma radiation GO:0071480 9.13 H2AX CHEK2 ATM
22 DNA damage induced protein phosphorylation GO:0006975 8.8 MAPK3 CHEK2 ATM

Molecular functions related to Scrotum Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(showing 4, show less)
# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.65 TARS1 MAPK3 EGFR CHEK2 ATM
2 kinase activity GO:0016301 9.46 MAPK3 EGFR CHEK2 ATM
3 protein kinase activity GO:0004672 9.26 MAPK3 EGFR CHEK2 ATM
4 nucleotide binding GO:0000166 9.02 TARS1 MAPK3 EGFR CHEK2 ATM

Sources for Scrotum Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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