MCID: SCR008
MIFTS: 58

Scrub Typhus

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Scrub Typhus

MalaCards integrated aliases for Scrub Typhus:

Name: Scrub Typhus 12 58 54 43 15 17 71
Typhus Fever Due to Rickettsia Tsutsugamushi 12 32
Tsutsugamushi Disease 12 58
Tsutsugamushi Fever 12 58
Chigger-Borne Rickettsiosis 12
Mite-Borne Rickettsiosis 12
Scrub Mite-Borne Typhus 12
Chigger-Borne Typhus 12
Japanese River Fever 12
Mite-Borne Typhus 12
Tropical Typhus 12
Scrub Typhus 12
Tsutsugamushi 12
Kedani Fever 12

Characteristics:

Orphanet epidemiological data:

58
scrub typhus
Prevalence: 1-9/100000 (Korea, Republic of),1-9/1000000 (Japan); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Scrub Typhus

Disease Ontology : 12 A typhus that has material basis in Orientia tsutsugamushi, which is transmitted by trombiculid mites (Leptotrombidium deliense). The infection has symptom fever, has symptom headache, has symptom muscle pain, has symptom cough, has symptom maculopapular rash, has symptom eschar, has symptom splenomegaly and has symptom lymphadenopathy.

MalaCards based summary : Scrub Typhus, also known as typhus fever due to rickettsia tsutsugamushi, is related to epidemic typhus and disseminated intravascular coagulation. An important gene associated with Scrub Typhus is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Doxycycline and Antibiotics, Antitubercular have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and t cells, and related phenotypes are fever and hyperhidrosis

Wikipedia : 74 Scrub typhus or bush typhus is a form of typhus caused by the intracellular parasite Orientia... more...

Related Diseases for Scrub Typhus

Diseases related to Scrub Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 814)
# Related Disease Score Top Affiliating Genes
1 epidemic typhus 31.4 TLR4 TLR2 TCN2 IL10 GPT CRP
2 disseminated intravascular coagulation 31.2 TNF IL10 GPT F3 CRP
3 transverse myelitis 31.1 TNF IL17A IL10
4 pancreatitis 31.0 TNF SLC17A5 IL1B IL10 CRP
5 pulmonary edema 30.9 TNF IL1B IL10 CRP
6 hemophagocytic lymphohistiocytosis 30.9 TNF IL18 IL10 IFNG GPT
7 optic neuritis 30.9 TNF IL1B IL10
8 neuritis 30.8 TNF IL1B IL10 IFNG
9 adult respiratory distress syndrome 30.8 TNF IL1B IL10
10 analbuminemia 30.8 SLC17A5 GPT F3 CRP
11 meningoencephalitis 30.8 TNF IL1B IL10 CRP CD40LG
12 duodenal ulcer 30.6 TNF TLR4 IL1B IL10
13 nocardiosis 30.6 TNF IFNG CRP
14 acute kidney failure 30.6 LCN2 IL18 HAVCR1 GPT
15 conjunctivitis 30.6 TNF IL10 IFNG
16 acalculous cholecystitis 30.5 GPT CRP CD40LG
17 liver cirrhosis 30.5 TLR2 SLC17A5 GPT F3
18 peptic ulcer disease 30.5 TNF IL1B IL10
19 chikungunya 30.5 TNF IL1B IL18
20 hantavirus hemorrhagic fever with renal syndrome 30.5 TNF F3 CRP CD40LG
21 haemophilus influenzae 30.5 TNF TLR2
22 acute myocarditis 30.4 TNF IL1B IL10 CRP
23 histiocytosis 30.4 TNF IL17A IFNG
24 lymphopenia 30.4 IL18 IL15 IL10 IFNG
25 splenic infarction 30.3 GPT F3 CRP CD40LG
26 polyneuropathy 30.3 TNF IL1B CRP CD40LG
27 allergic hypersensitivity disease 30.3 TNF IL17A IL10 IFNG
28 plague 30.3 TNF TLR4 TLR2 IL1B IL10
29 myelitis 30.2 TNF IL17A IL10 CD40LG
30 acute pancreatitis 30.2 TNF TLR4 IL1B IL18 IL10 GPT
31 brain edema 30.2 IL1B IFNG CRP
32 bilirubin metabolic disorder 30.2 SLC17A5 GPT F3 CRP CD40LG
33 exanthem 30.2 TNF IL1B IL10 IFNG GPT F3
34 acute pyelonephritis 30.2 LCN2 IL10 IFNG GPT CRP
35 japanese spotted fever 30.2 CRP CD40LG AFF2
36 astrakhan spotted fever 30.2 F3 CD40LG
37 hepatitis 30.1 TNF SLC17A5 IFNG HAVCR1 GPT
38 spotted fever rickettsiosis 30.1 TNF IL10 IFNG IDO1
39 gastroenteritis 30.1 TNF IL1B IL10 IFNG CRP
40 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.1 IL17A IL10 IFNG
41 pericardial effusion 30.1 GPT F3 CRP CD40LG
42 gastritis 30.1 TNF TLR4 IL1B IL17A IL10
43 mononeuritis multiplex 30.0 TNF CRP CD40LG
44 papilledema 30.0 F3 CRP CD40LG
45 thrombocytopenia due to platelet alloimmunization 30.0 IL17A IL10 CD40LG
46 encephalitis 30.0 TNF TLR2 IL1B IL10 IDO1 CD40LG
47 infective endocarditis 30.0 TNF TLR2 IL17A CRP
48 hepatitis e 29.9 TNF IFNG GPT CD40LG
49 acute disseminated encephalomyelitis 29.9 IL1B IL10 CD40LG
50 central nervous system disease 29.9 TNF IL1B IL17A IFNG

Graphical network of the top 20 diseases related to Scrub Typhus:



Diseases related to Scrub Typhus

Symptoms & Phenotypes for Scrub Typhus

Human phenotypes related to Scrub Typhus:

58 31 (show all 28)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
2 hyperhidrosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0000975
3 skin rash 58 31 hallmark (90%) Very frequent (99-80%) HP:0000988
4 myalgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0003326
5 cough 58 31 hallmark (90%) Very frequent (99-80%) HP:0012735
6 lethargy 58 31 hallmark (90%) Very frequent (99-80%) HP:0001254
7 photophobia 58 31 frequent (33%) Frequent (79-30%) HP:0000613
8 macule 58 31 frequent (33%) Frequent (79-30%) HP:0012733
9 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002017
10 abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002027
11 gangrene 58 31 frequent (33%) Frequent (79-30%) HP:0100758
12 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
13 lymphadenopathy 58 31 frequent (33%) Frequent (79-30%) HP:0002716
14 hypotension 58 31 frequent (33%) Frequent (79-30%) HP:0002615
15 anterior uveitis 58 31 frequent (33%) Frequent (79-30%) HP:0012122
16 splenomegaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0001744
17 renal insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0000083
18 dyspnea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002094
19 tremor 58 31 occasional (7.5%) Occasional (29-5%) HP:0001337
20 restrictive ventilatory defect 58 31 occasional (7.5%) Occasional (29-5%) HP:0002091
21 myocarditis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012819
22 meningitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001287
23 abnormal bleeding 58 31 occasional (7.5%) Occasional (29-5%) HP:0001892
24 encephalitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002383
25 seizure 31 occasional (7.5%) HP:0001250
26 behavioral abnormality 58 Occasional (29-5%)
27 seizures 58 Occasional (29-5%)
28 reduced consciousness/confusion 58 Very frequent (99-80%)

GenomeRNAi Phenotypes related to Scrub Typhus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.44 CD40LG IL10 IL17A IL18 IL1B LCN2
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.44 IL10 IL17A IL18 IL1B LCN2 TNF

MGI Mouse Phenotypes related to Scrub Typhus:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.31 CD40LG CRP F3 IDO1 IFNG IL10
2 hematopoietic system MP:0005397 10.25 CD40LG F3 IDO1 IFNG IL10 IL15
3 homeostasis/metabolism MP:0005376 10.25 CD40LG CRP F3 IDO1 IFNG IL10
4 growth/size/body region MP:0005378 10.23 F3 IFNG IL10 IL15 IL17A IL18
5 cellular MP:0005384 10.22 CD40LG F3 IDO1 IFNG IL10 IL18
6 immune system MP:0005387 10.21 CD40LG CRP F3 IDO1 IFNG IL10
7 mortality/aging MP:0010768 10.07 CD40LG F3 IFNG IL10 IL15 IL17A
8 integument MP:0010771 10.02 CD40LG F3 IFNG IL10 IL17A IL18
9 muscle MP:0005369 9.76 F3 IDO1 IFNG IL10 IL18 TLR2
10 neoplasm MP:0002006 9.5 F3 IFNG IL10 IL1B TLR2 TLR4
11 renal/urinary system MP:0005367 9.23 CD40LG IDO1 IFNG IL15 IL17A LCN2

Drugs & Therapeutics for Scrub Typhus

Drugs for Scrub Typhus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2 Antibiotics, Antitubercular Phase 4
3
Telithromycin Approved Phase 3 191114-48-4 70789201 5462516
4
Azithromycin Approved Phase 3 83905-01-5 447043 55185
5
Sulfamethoxazole Approved Phase 3 723-46-6 5329
6
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
7 Anti-Infective Agents Phase 3
8 Antiprotozoal Agents Phase 3
9 Anti-Bacterial Agents Phase 3
10 Antiparasitic Agents Phase 3
11 Antimalarials Phase 3
12 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
13
Ethanol Approved 64-17-5 702
14
Rifampicin Approved 13292-46-1 5381226 5458213
15
carbamide peroxide Approved 124-43-6
16 Antitubercular Agents
17 Immunoglobulins
18 Antibodies
19 Vaccines

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 The Scrub Typhus Antibiotic Resistance Trial (START) Comparing Doxycycline and Azithromycin Treatment Modalities in Areas of Reported Antimicrobial Resistance for Scrub Typhus Recruiting NCT03083197 Phase 4 Doxycycline 7 days;Doxycycline 3 days;Azithromycin 3 days
2 Phase 3 Study of Controlled Trial: 5-day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00351182 Phase 3 Telithromycin;Doxycycline
3 Parallel Group, Double Blinded, 1:1, Randomized Controlled Phase III Trial of Co-trimoxazole Versus Azithromycin for the Treatment of Undifferentiated Fever In Nepal Active, not recruiting NCT02773407 Phase 3 Azithromycin;Co-trimoxazole
4 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
5 A Multicentre Observational Study to Describe the Prevalence of Scrub Typhus Defined as a Positive Rapid Diagnostic Test Among Selected Patients Presenting With Fever to Clinics in Myanmar Completed NCT03269266
6 Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00568711 doxycycline;rifampin
7 The Natural Immune Response In Pediatric Scrub Typhus In Chiangrai Completed NCT02398162
8 Rickettsial Disease in Febrile Hospitalised Patients in a Tertiary Referral Hospital in Bangladesh Completed NCT02339259
9 Background Seroprevalence of Rickettsial Infections in Myanmar Completed NCT03847870
10 Indian Intensive Care Case Mix and Practice Patterns Study Completed NCT01384929
11 Prediction and Early Diagnosis for Cardiovascular Disease Complicated by Scrub Typhus Infection Recruiting NCT03274869
12 Eschar Investigations to Improve Diagnostics, Understand Early Immune Responses and Characterize Strains for Vaccines in Scrub Typhus Recruiting NCT02915861
13 Diagnostic Accuracy of the DPP Fever Panel II Asia and the DPP Micro Reader Recruiting NCT04299412
14 The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents Active, not recruiting NCT02876367

Search NIH Clinical Center for Scrub Typhus

Cochrane evidence based reviews: scrub typhus

Genetic Tests for Scrub Typhus

Anatomical Context for Scrub Typhus

MalaCards organs/tissues related to Scrub Typhus:

40
Testes, Kidney, T Cells, Liver, Skin, Endothelial, Lung

Publications for Scrub Typhus

Articles related to Scrub Typhus:

(show top 50) (show all 1816)
# Title Authors PMID Year
1
Does IL-17 play a role in hepatic dysfunction of scrub typhus patients? 54 61
19485773 2010
2
The difference in clinical characteristics between acute Q fever and scrub typhus in southern Taiwan. 54 61
18977677 2009
3
Comparison of indirect immunofluorescence assays for diagnosis of scrub typhus and murine typhus using venous blood and finger prick filter paper blood spots. 54 61
19407134 2009
4
Hepatic dysfunction in pediatric scrub typhus: role of liver function test in diagnosis and marker of disease severity. 61 54
18181321 2007
5
Scrub typhus among hospitalised patients with febrile illness in South India: magnitude and clinical predictors. 54 61
16368461 2006
6
Evaluation of an immunoglobulin M capture enzyme-linked immunosorbent assay for diagnosis of Orientia tsutsugamushi infection. 54 61
12738637 2003
7
Early diagnosis of scrub typhus with a rapid flow assay using recombinant major outer membrane protein antigen (r56) of Orientia tsutsugamushi. 61 54
11238230 2001
8
Serological reactivity of sera from scrub typhus patients against Weil-Felix test antigens. 61 54
8133798 1993
9
Hemophagocytic Lymphohistiocytosis in Children: Clinical Profile and Outcome. 61
32218098 2020
10
Design, expression, and evaluation of novel multiepitope chimeric antigen of Wuchereria bancrofti for the diagnosis of lymphatic filariasis - A structure-based strategy. 61
32222640 2020
11
Scrub Typhus with Respiratory Symptoms. 61
32536641 2020
12
Infection-Associated Opsoclonus: A Retrospective Case Record Analysis and Review of Literature. 61
32216501 2020
13
Optimization and evaluation of a multiplex quantitative PCR assay for detection of nucleic acids in human blood from patients with spotted fever rickettsiosis, typhus rickettsiosis, scrub typhus, monocytic ehrlichiosis, and granulocytic anaplasmosis. 61
32493778 2020
14
Clinical Profile of Scrub Typhus in Newborns. 61
32562407 2020
15
Stye Can Lie! - A Rare Presentation of Scrub Typhus Eschar. 61
32495216 2020
16
Epidemiologic Changes of Scrub Typhus in China, 1952-2016. 61
32441637 2020
17
Scrub typhus in patients with acute febrile illness: a 5-year study from India. 61
31790119 2020
18
Establishment of Recombinase Polymerase Amplification assay for rapid and sensitive detection of Orientia tsutsugamushi in Southeast Asia. 61
32492397 2020
19
A deubiquitylase with an unusually high-affinity ubiquitin-binding domain from the scrub typhus pathogen Orientia tsutsugamushi. 61
32393759 2020
20
Hepatic and Renal Profile of Scrub Typhus Patients at a Tertiary Care Center in India. 61
32494535 2020
21
Cerebellitis as a rare manifestation of scrub typhus fever. 61
32414774 2020
22
Scrub Typhus and the Misconception of Doxycycline Resistance. 61
31570937 2020
23
Serum C-reactive protein and procalcitonin values in acute Q fever, scrub typhus, and murine typhus. 61
32398008 2020
24
Scrub typhus as a rare cause of acute pyelonephritis: case report. 61
32375669 2020
25
Risk Factors for Scrub Typhus, Murine Typhus, and Spotted Fever Seropositivity in Urban Areas, Rural Plains, and Peri-Forest Hill Villages in South India: A Cross-Sectional Study. 61
32458785 2020
26
Innovative Distance Learning Tool for Morphological Identification of Chigger Mites (Actinotrichida) as Vectors of Scrub Typhus: A Pilot Study. 61
32260591 2020
27
Evaluation of recombinant type-specific antigens of Orientia tsutsugamushi which were expressed by baculovirus-insect cell system as antigens for indirect immunofluorescent assay in the serological diagnosis of scrub typhus. 61
32350215 2020
28
Hospital based serological evidence of rickettsial diseases and assessment diagnostic tests of pyrexia of unknown origin. 61
31805833 2020
29
Seroprevalence & seroincidence of Orientia tsutsugamushi infection in Gorakhpur, Uttar Pradesh, India: A community-based serosurvey during lean (April-May) & epidemic (October-November) periods for acute encephalitis syndrome. 61
32461399 2020
30
Clinical Features of Rickettsial Infection in Children in Tropical Australia-A Report of 15 Cases. 61
32252063 2020
31
Clinical profile and outcome of patients with Crimean Congo haemorrhagic fever: a hospital based observational study from Rajasthan, India. 61
32286662 2020
32
Serum procalcitonin as a biomarker of bloodstream infection & focal bacterial infection in febrile patients. 61
32461398 2020
33
Diagnosis of severe scrub typhus infection by next-generation sequencing:a case report. 61
32264829 2020
34
A case of Henoch-Schönlein purpura associated with scrub typhus. 61
32303196 2020
35
Relative Abundance of a Vector of Scrub Typhus, Leptotrombidium sialkotense, in Southern Yunnan Province, China. 61
32418384 2020
36
Scrub Typhus: Historic Perspective and Current Status of the Worldwide Presence of Orientia Species. 61
32244598 2020
37
Clinical Characteristics and Outcome of Children Hospitalized With Scrub Typhus in an Area of Endemicity. 61
30864670 2020
38
Scrub typhus and leptospirosis in rural and urban settings of central India: a preliminary evaluation. 61
31779530 2020
39
Clinicoepidemiological and Genotyping Correlation of Pediatric Scrub Typhus from Chandigarh, India. 61
32284475 2020
40
The estimated burden of scrub typhus in Thailand from national surveillance data (2003-2018). 61
32287307 2020
41
Polarized lung inflammation and Tie2/angiopoietin-mediated endothelial dysfunction during severe Orientia tsutsugamushi infection. 61
32119672 2020
42
The epidemiology, characteristics and outbreaks of human leptospirosis and the association with animals in Taiwan, 2007-2014: A nationwide database study. 61
31916706 2020
43
Aetiology and short-term outcome of acute respiratory distress syndrome: a real-world experience from a medical intensive care unit in southern India. 61
32539030 2020
44
Clinical Profile and Outcome of Adult Patients with Scrub Typhus in a Tertiary Care Centre of Eastern Nepal. 61
32347822 2020
45
Risk of cerebro- and cardiovascular disease in patients with scrub typhus. 61
31776872 2020
46
Extracellular vesicle-associated antigens as a new vaccine platform against scrub typhus. 61
31941602 2020
47
Application of Extracorporeal Membrane Oxygenation in Patients with Scrub Typhus Complicated with Acute Respiratory Distress Syndrome. 61
32364912 2020
48
Clinical significance of abnormal chest radiographic findings for acute kidney injury in patients with scrub typhus. 61
32164121 2020
49
Clinical Score System to Differentiate Severe Fever with Thrombocytopenia Syndrome Patients from Patients with Scrub Typhus or Hemorrhagic Fever with Renal Syndrome in Korea. 61
32193903 2020
50
Antinuclear antibodies in infectious diseases. 61
31718355 2020

Variations for Scrub Typhus

Expression for Scrub Typhus

Search GEO for disease gene expression data for Scrub Typhus.

Pathways for Scrub Typhus

Pathways related to Scrub Typhus according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 TNF TLR4 TLR2 LCN2 IL1B IL18
2
Show member pathways
13.7 TNF TLR4 IL1B IL18 IL17A IL15
3
Show member pathways
13.45 TNF TLR4 TLR2 IL1B IL18 IL17A
4
Show member pathways
13.4 TNF LCN2 IL1B IL18 IL17A IL15
5
Show member pathways
13.32 TNF IL1B IL18 IL17A IL15 IL10
6
Show member pathways
13.08 TNF TLR4 TLR2 IL1B IL10 IFNG
7
Show member pathways
12.9 TNF IL1B IL17A IL15 IL10 IFNG
8
Show member pathways
12.86 TNF TLR4 TLR2 IL1B IL18 IFNG
9
Show member pathways
12.78 TNF TLR4 TLR2 IL1B IL18 F3
10
Show member pathways
12.73 TNF TLR4 TLR2 IL1B CD40LG
11
Show member pathways
12.67 TNF TLR4 TLR2 IL1B IL17A IL10
12
Show member pathways
12.66 TNF IL18 IL10 IFNG CD40LG
13
Show member pathways
12.65 TNF IL1B IL18 IL17A IL10 IFNG
14
Show member pathways
12.65 TNF TLR4 TLR2 IL1B IL18 IL17A
15
Show member pathways
12.62 TNF TLR4 TLR2 IL1B CD40LG
16 12.57 TNF TLR2 IL1B IL17A IL10 IFNG
17 12.41 TNF TLR4 IL1B IL18
18
Show member pathways
12.4 TNF TCN2 IL1B IFNG CRP
19
Show member pathways
12.4 TNF TLR2 LCN2 IL1B IL17A IFNG
20 12.37 TNF TLR4 TLR2 IL1B IL18
21
Show member pathways
12.32 TNF TLR4 IL1B IFNG
22
Show member pathways
12.32 TNF IL1B IL18 IL17A IL15 IL10
23
Show member pathways
12.32 TNF TLR4 TLR2 IL1B IL10 IFNG
24 12.3 TNF TLR4 IL1B IL18
25 12.28 TNF TLR4 TLR2 IL1B IL18 IL10
26 12.26 TNF TLR4 IL1B IL18
27
Show member pathways
12.25 TNF TLR4 TLR2 IL1B IFNG
28
Show member pathways
12.23 TNF TLR4 IL1B IFNG
29 12.21 TNF TLR4 TLR2 IFNG
30 12.09 TNF TLR4 IL1B IL18 IL10
31 12.08 TNF LCN2 IL1B IL18 IL17A IL10
32 12.06 TNF TLR4 IL1B IFNG
33 12.05 TNF IL15 IL10 IFNG
34 12.02 TNF TLR4 TLR2 IL1B IL10 IFNG
35 11.99 TNF TLR4 IL1B CD40LG
36
Show member pathways
11.94 TLR4 TLR2 IL1B IL17A IFNG
37 11.84 TNF TLR4 IL1B IL10
38 11.82 TNF IL1B IL10 IFNG
39
Show member pathways
11.78 TNF IFNG CD40LG
40
Show member pathways
11.78 TNF TLR4 TLR2 IL1B IL18 IL17A
41 11.77 TNF IL1B IL18 IL17A IL15 IL10
42
Show member pathways
11.75 TNF IL1B IFNG CD40LG
43 11.71 TNF TLR4 TLR2 IL1B IL18
44 11.61 TNF IL1B IL18 IL10
45 11.59 TNF TLR4 TLR2 IL1B IL18 IFNG
46 11.56 TNF IL1B IFNG
47 11.53 TNF TLR4 TLR2 IL1B IL18 IL17A
48 11.52 TNF IL1B IFNG
49
Show member pathways
11.46 TNF IL15 IL10 IFNG
50 11.44 TNF TLR4 IL1B IL10

GO Terms for Scrub Typhus

Cellular components related to Scrub Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TNF TCN2 LCN2 IL1B IL18 IL17A
2 cell surface GO:0009986 9.7 TNF TLR4 TLR2 IL15 HAVCR1 F3
3 extracellular space GO:0005615 9.44 TNF TCN2 LCN2 IL1B IL18 IL17A

Biological processes related to Scrub Typhus according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.25 TNF TLR4 TLR2 IL1B IL18 IL17A
2 defense response to bacterium GO:0042742 10.05 TNF TLR4 LCN2 IL10
3 cell-cell signaling GO:0007267 10.04 IL1B IL18 IL17A IL15
4 positive regulation of gene expression GO:0010628 10.02 TNF TLR4 TLR2 LCN2 IL1B IL18
5 cellular response to lipopolysaccharide GO:0071222 10 TNF TLR4 LCN2 IL1B IL10
6 response to lipopolysaccharide GO:0032496 10 TLR4 TLR2 IL1B IL10 IDO1
7 cytokine-mediated signaling pathway GO:0019221 10 TNF LCN2 IL1B IL18 IL17A IL10
8 immune response GO:0006955 9.96 TNF TLR4 TLR2 IL1B IL18 IL17A
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 TNF TLR4 TLR2 IL1B IL18 CD40LG
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.93 TNF IL18 IL15 IFNG
11 positive regulation of JNK cascade GO:0046330 9.92 TNF TLR4 IL1B
12 regulation of insulin secretion GO:0050796 9.9 TNF IL1B IFNG
13 cellular response to organic cyclic compound GO:0071407 9.9 TNF IL1B IL18
14 positive regulation of T cell proliferation GO:0042102 9.89 IL1B IL15 CD40LG
15 positive regulation of interleukin-6 production GO:0032755 9.88 TNF TLR4 TLR2 IL1B
16 negative regulation of interleukin-6 production GO:0032715 9.86 TNF TLR4 IL10
17 positive regulation of phagocytosis GO:0050766 9.86 TNF IL1B IL15 IFNG
18 positive regulation of cytokine secretion GO:0050715 9.85 TNF IL10 IFNG
19 microglial cell activation GO:0001774 9.85 TNF TLR2 IFNG
20 positive regulation of interferon-gamma production GO:0032729 9.84 TNF TLR4 IL1B IL18
21 positive regulation of interleukin-10 production GO:0032733 9.83 TLR4 TLR2 CD40LG
22 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.83 TNF TLR4 IL17A
23 positive regulation of osteoclast differentiation GO:0045672 9.83 TNF IL17A IFNG
24 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 TNF TLR4 IL1B IFNG
25 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.83 TNF TLR4 TLR2 IL1B IL18
26 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.82 TLR4 IL17A IFNG
27 positive regulation of chemokine production GO:0032722 9.82 TNF TLR4 TLR2
28 positive regulation of interleukin-8 secretion GO:2000484 9.81 TNF TLR4 TLR2
29 astrocyte activation GO:0048143 9.81 TNF IL1B IFNG
30 positive regulation of interleukin-8 production GO:0032757 9.81 TNF TLR4 TLR2 IL1B
31 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.8 TNF IL1B IFNG
32 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 TNF TLR4 TLR2 IL1B IL18
33 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.79 TNF IL1B IL10
34 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.79 TLR4 TLR2 IFNG
35 positive regulation of chemokine biosynthetic process GO:0045080 9.77 TNF IL1B IFNG
36 positive regulation of neuroinflammatory response GO:0150078 9.76 TNF IL1B IL18
37 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.74 TNF TLR4
38 neutrophil activation GO:0042119 9.74 IL18 IL15
39 I-kappaB phosphorylation GO:0007252 9.74 TLR4 TLR2
40 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.74 IL1B IL18
41 response to molecule of bacterial origin GO:0002237 9.74 TLR2 IL10
42 positive regulation of MHC class II biosynthetic process GO:0045348 9.74 TLR4 IL10 IFNG
43 negative regulation of amyloid-beta clearance GO:1900222 9.73 TNF IFNG
44 cellular response to lipoteichoic acid GO:0071223 9.73 TLR4 TLR2
45 T-helper 1 type immune response GO:0042088 9.73 TLR4 IL18
46 negative regulation of lipid storage GO:0010888 9.73 TNF CRP
47 interleukin-6 production GO:0032635 9.73 IL1B IL18
48 regulation of establishment of endothelial barrier GO:1903140 9.72 TNF IL1B
49 endothelial cell apoptotic process GO:0072577 9.72 TNF IL10
50 regulation of defense response to virus by host GO:0050691 9.72 IL1B IL15

Molecular functions related to Scrub Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 TNF IL1B IL18 IL17A IL15 IL10
2 lipopolysaccharide receptor activity GO:0001875 8.96 TLR4 TLR2

Sources for Scrub Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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