MCID: SCR008
MIFTS: 57

Scrub Typhus

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Scrub Typhus

MalaCards integrated aliases for Scrub Typhus:

Name: Scrub Typhus 12 58 54 44 15 17 70
Typhus Fever Due to Rickettsia Tsutsugamushi 12 32
Tsutsugamushi Disease 12 58
Tsutsugamushi Fever 12 58
Chigger-Borne Rickettsiosis 12
Mite-Borne Rickettsiosis 12
Scrub Mite-Borne Typhus 12
Chigger-Borne Typhus 12
Japanese River Fever 12
Mite-Borne Typhus 12
Tropical Typhus 12
Scrub Typhus 12
Tsutsugamushi 12
Kedani Fever 12

Characteristics:

Orphanet epidemiological data:

58
scrub typhus
Prevalence: 1-9/100000 (Korea, Republic of),1-9/1000000 (Japan); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Scrub Typhus

Disease Ontology : 12 A typhus that has material basis in Orientia tsutsugamushi, which is transmitted by trombiculid mites (Leptotrombidium deliense). The infection has symptom fever, has symptom headache, has symptom muscle pain, has symptom cough, has symptom maculopapular rash, has symptom eschar, has symptom splenomegaly and has symptom lymphadenopathy.

MalaCards based summary : Scrub Typhus, also known as typhus fever due to rickettsia tsutsugamushi, is related to epidemic typhus and meningoencephalitis. An important gene associated with Scrub Typhus is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include endothelial, t cells and skin, and related phenotypes are hyperhidrosis and fever

Wikipedia : 73 Scrub typhus or bush typhus is a form of typhus caused by the intracellular parasite Orientia... more...

Related Diseases for Scrub Typhus

Diseases related to Scrub Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 803)
# Related Disease Score Top Affiliating Genes
1 epidemic typhus 32.4 TNF TCN2 IL10 GPT CRP
2 meningoencephalitis 31.5 TNF SLC17A5 IL10 CRP
3 vasculitis 31.3 TNF LCN2 IL17A CRP
4 myelitis 31.1 TNF IL17A IL10
5 dengue disease 31.1 TNF IL10 IFNG
6 hantavirus hemorrhagic fever with renal syndrome 31.1 TNF F3 CRP
7 transverse myelitis 31.0 TNF IL17A IL10
8 disseminated intravascular coagulation 31.0 TNF IL10 GPT F3 CRP
9 spotted fever 31.0 TNF IL10 IFNG IDO1
10 acalculous cholecystitis 30.9 GPT CRP
11 splenic infarction 30.9 GPT F3 CRP
12 rocky mountain spotted fever 30.8 SLC17A5 GPT F3
13 hemophagocytic lymphohistiocytosis 30.8 TNF IL18 IL10 IFNG GPT
14 pulmonary edema 30.8 TNF IL1B IL10 CRP
15 exanthem 30.7 TNF IL1B IL18 IL10 IFNG GPT
16 encephalitis 30.7 TNF TLR2 IL1B IL10 IDO1
17 aseptic meningitis 30.7 TNF IL1B IL10 IFNG CRP
18 liver disease 30.7 TNF SLC17A5 IL1B GPT F3
19 macrophage activation syndrome 30.7 TNF IL18 CRP
20 optic neuritis 30.6 TNF IL1B IL10
21 neutropenia 30.6 TNF IL1B IL10 GPT CRP
22 pericardial effusion 30.6 GPT F3 CRP
23 purpura 30.6 TNF IL10 IFNG F3 CRP
24 neuritis 30.6 TNF IL1B IL10 IFNG
25 urinary tract infection 30.6 TLR4 LCN2 CRP
26 orchitis 30.6 TNF IL1B IL10 CRP
27 hepatitis e 30.5 TNF IFNG GPT
28 hemopericardium 30.5 F3 CRP
29 analbuminemia 30.5 SLC17A5 GPT F3 CRP
30 respiratory failure 30.5 TNF TLR4 IL1B IL10 GPT F3
31 typhoid fever 30.5 TNF TLR4 IL1B IFNG GPT CRP
32 acute kidney failure 30.5 LCN2 IL18 HAVCR1 GPT
33 granulomatous hepatitis 30.4 TNF GPT CRP
34 bilirubin metabolic disorder 30.4 TNF SLC17A5 IL1B GPT F3 CRP
35 acute pyelonephritis 30.4 LCN2 IL10 GPT CRP
36 common cold 30.4 TNF IL1B IL17A IL10
37 q fever 30.4 TNF TLR4 TLR2 IL1B IL10 IFNG
38 duodenal ulcer 30.4 TNF TLR4 IL1B IL10
39 acute myocarditis 30.4 TNF IL10 CRP
40 chickenpox 30.4 TNF IL10 IFNG CRP
41 histiocytosis 30.4 TNF IL17A IFNG
42 myocarditis 30.4 TNF TLR4 IL1B IL18 IL17A IL10
43 hepatorenal syndrome 30.3 LCN2 IL18 GPT
44 nocardiosis 30.3 TNF IFNG CRP
45 radiculopathy 30.3 IL17A IL15 IL10
46 intracranial hypertension 30.3 TNF IL1B F3
47 herpes zoster 30.3 TNF TLR2 IL10 IFNG
48 peptic ulcer disease 30.3 TNF IL1B IL10
49 poliomyelitis 30.3 TNF IL10 IFNG
50 leptospirosis 30.2 TNF TLR2 LCN2 IL1B IL18 IL10

Graphical network of the top 20 diseases related to Scrub Typhus:



Diseases related to Scrub Typhus

Symptoms & Phenotypes for Scrub Typhus

Human phenotypes related to Scrub Typhus:

58 31 (show all 28)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperhidrosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0000975
2 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
3 myalgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0003326
4 cough 58 31 hallmark (90%) Very frequent (99-80%) HP:0012735
5 skin rash 58 31 hallmark (90%) Very frequent (99-80%) HP:0000988
6 lethargy 58 31 hallmark (90%) Very frequent (99-80%) HP:0001254
7 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002017
8 hypotension 58 31 frequent (33%) Frequent (79-30%) HP:0002615
9 photophobia 58 31 frequent (33%) Frequent (79-30%) HP:0000613
10 abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002027
11 macule 58 31 frequent (33%) Frequent (79-30%) HP:0012733
12 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
13 gangrene 58 31 frequent (33%) Frequent (79-30%) HP:0100758
14 lymphadenopathy 58 31 frequent (33%) Frequent (79-30%) HP:0002716
15 anterior uveitis 58 31 frequent (33%) Frequent (79-30%) HP:0012122
16 tremor 58 31 occasional (7.5%) Occasional (29-5%) HP:0001337
17 encephalitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002383
18 splenomegaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0001744
19 renal insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0000083
20 dyspnea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002094
21 myocarditis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012819
22 meningitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001287
23 abnormal bleeding 58 31 occasional (7.5%) Occasional (29-5%) HP:0001892
24 restrictive ventilatory defect 58 31 occasional (7.5%) Occasional (29-5%) HP:0002091
25 seizure 31 occasional (7.5%) HP:0001250
26 seizures 58 Occasional (29-5%)
27 behavioral abnormality 58 Occasional (29-5%)
28 reduced consciousness/confusion 58 Very frequent (99-80%)

MGI Mouse Phenotypes related to Scrub Typhus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 CRP F3 IDO1 IFNG IL10 IL15
2 hematopoietic system MP:0005397 10.18 F3 IDO1 IFNG IL10 IL15 IL17A
3 homeostasis/metabolism MP:0005376 10.18 CRP F3 IDO1 IFNG IL10 IL17A
4 cellular MP:0005384 10.17 F3 HSPA4 IDO1 IFNG IL10 IL18
5 immune system MP:0005387 10.13 CRP F3 IDO1 IFNG IL10 IL15
6 mortality/aging MP:0010768 9.97 F3 HSPA4 IFNG IL10 IL15 IL17A
7 integument MP:0010771 9.91 F3 IFNG IL10 IL17A IL18 IL1B
8 muscle MP:0005369 9.56 F3 IDO1 IFNG IL10 IL18 TLR2
9 neoplasm MP:0002006 9.17 F3 IFNG IL10 IL1B TLR2 TLR4

Drugs & Therapeutics for Scrub Typhus

Drugs for Scrub Typhus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 447043 55185
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3 Antibiotics, Antitubercular Phase 4
4 Antimalarials Phase 4
5 Anti-Bacterial Agents Phase 4
6 Antiparasitic Agents Phase 4
7 Anti-Infective Agents Phase 4
8 Antiprotozoal Agents Phase 4
9
Telithromycin Approved Phase 3 191114-48-4 5462516 70789201
10
Ethanol Approved 64-17-5 702
11
carbamide peroxide Approved 124-43-6
12
Rifampicin Approved 13292-46-1 5381226 5458213
13 Antibodies
14 Immunoglobulins
15 Antitubercular Agents
16 Vaccines

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 The Scrub Typhus Antibiotic Resistance Trial (START) Comparing Doxycycline and Azithromycin Treatment Modalities in Areas of Reported Antimicrobial Resistance for Scrub Typhus Recruiting NCT03083197 Phase 4 Doxycycline 7 days;Doxycycline 3 days;Azithromycin 3 days
2 Phase 3 Study of Controlled Trial: 5-day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00351182 Phase 3 Telithromycin;Doxycycline
3 The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents Unknown status NCT02876367
4 A Multicentre Observational Study to Describe the Prevalence of Scrub Typhus Defined as a Positive Rapid Diagnostic Test Among Selected Patients Presenting With Fever to Clinics in Myanmar Completed NCT03269266
5 Background Seroprevalence of Rickettsial Infections in Myanmar Completed NCT03847870
6 Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00568711 doxycycline;rifampin
7 The Natural Immune Response In Pediatric Scrub Typhus In Chiangrai Completed NCT02398162
8 Eschar Investigations to Improve Diagnostics, Understand Early Immune Responses and Characterize Strains for Vaccines in Scrub Typhus Recruiting NCT02915861
9 The Epidemiology Of Scrub Typhus And Rickettsial Infections In A Highly Endemic Rural Setting In South India: Population-Based Cohort Study Recruiting NCT04506944
10 Prediction and Early Diagnosis for Cardiovascular Disease Complicated by Scrub Typhus Infection Recruiting NCT03274869
11 Diagnostic Accuracy of the DPP Fever Panel II Asia and the DPP Micro Reader Recruiting NCT04299412

Search NIH Clinical Center for Scrub Typhus

Cochrane evidence based reviews: scrub typhus

Genetic Tests for Scrub Typhus

Anatomical Context for Scrub Typhus

MalaCards organs/tissues related to Scrub Typhus:

40
Endothelial, T Cells, Skin, Monocytes, Spleen, Bone Marrow, Whole Blood

Publications for Scrub Typhus

Articles related to Scrub Typhus:

(show top 50) (show all 1935)
# Title Authors PMID Year
1
Does IL-17 play a role in hepatic dysfunction of scrub typhus patients? 61 54
19485773 2010
2
Comparison of indirect immunofluorescence assays for diagnosis of scrub typhus and murine typhus using venous blood and finger prick filter paper blood spots. 54 61
19407134 2009
3
The difference in clinical characteristics between acute Q fever and scrub typhus in southern Taiwan. 61 54
18977677 2009
4
Hepatic dysfunction in pediatric scrub typhus: role of liver function test in diagnosis and marker of disease severity. 61 54
18181321 2007
5
Scrub typhus among hospitalised patients with febrile illness in South India: magnitude and clinical predictors. 54 61
16368461 2006
6
Evaluation of an immunoglobulin M capture enzyme-linked immunosorbent assay for diagnosis of Orientia tsutsugamushi infection. 54 61
12738637 2003
7
Early diagnosis of scrub typhus with a rapid flow assay using recombinant major outer membrane protein antigen (r56) of Orientia tsutsugamushi. 54 61
11238230 2001
8
Serological reactivity of sera from scrub typhus patients against Weil-Felix test antigens. 54 61
8133798 1993
9
Infestation and seasonal fluctuation of chigger mites on the Southeast Asian house rat (Rattus brunneusculus) in southern Yunnan Province, China. 61
33665081 2021
10
Stye Can Lie! - A Rare Presentation of Scrub Typhus Eschar. 61
32495216 2021
11
High initial IgG antibody levels against Orientia tsutsugamushi are associated with an increased risk of severe scrub typhus infection. 61
33735183 2021
12
Misdiagnosis of scrub typhus as hemorrhagic fever with renal syndrome and potential co-infection of both diseases in patients in Shandong Province, China, 2013-2014. 61
33784301 2021
13
Seroprevalence and Factors Associated with Scrub Typhus Infection among Forestry Workers in National Park Offices in South Korea. 61
33803616 2021
14
Acute cerebellar ataxia and peripheral neuropathy due to an atypical infection. 61
33731395 2021
15
Genome-Wide Association Study Identifies Eight Novel Loci for Susceptibility of Scrub Typhus and Highlights Immune-Related Signaling Pathways in Its Pathogenesis. 61
33807835 2021
16
A rare case of scrub typhus vasculitis presenting as acute coronary syndrome diagnosed by skin manifestations. 61
33666032 2021
17
Seroprevalence of Scrub Typhus, Murine Typhus and Spotted Fever Group in North Korean Refugees. 61
33676004 2021
18
Current tools for the diagnosis and detection of spotted fever group Rickettsia. 61
33713627 2021
19
Orientia tsutsugamushi DNA load and genotypes in blood as a marker of severity. 61
33309595 2021
20
Re-expansion Pulmonary Edema-A Rare Entity: A Thin Line between Pulmonary and Cardiac Decompensation. 61
33790520 2021
21
Targeted capture and sequencing of Orientia tsutsugamushi genomes from chiggers and humans. 61
33771726 2021
22
Chigger Mites (Acariformes: Trombiculidae) of Chiloé Island, Chile, With Descriptions of Two New Species and New Data on the Genus Herpetacarus. 61
33300548 2021
23
Infestation and distribution of chigger mites on Brown rat (Rattus norvegicus) in Yunnan Province, Southwest China. 61
33797533 2021
24
Climatic requirements of the eastern paralysis tick, Ixodes holocyclus, with a consideration of its possible geographic range up to 2090. 61
33513402 2021
25
An outbreak investigation of scrub typhus in Nepal: confirmation of local transmission. 61
33602136 2021
26
Descriptive epidemiology of rickettsial infections in Japan: Scrub typhus and Japanese spotted fever, 2007-2016. 61
33610785 2021
27
Hyperferritinemia in children hospitalized with scrub typhus. 61
33597024 2021
28
Urinary Exosomal microRNA-21 as a Marker for Scrub Typhus-Associated Acute Kidney Injury. 61
33596145 2021
29
Scrub typhus-related hepatotoxicity: The Indian scenario. 61
33612084 2021
30
Non-linear effect of different humidity types on scrub typhus occurrence in endemic provinces, Thailand. 61
33665401 2021
31
Rodent bites in a quadriplegic. 61
33541246 2021
32
Serological evidence indicates widespread distribution of rickettsioses in Myanmar. 61
33310022 2021
33
Research Advances of Leptotrombidium scutellare in China. 61
33684981 2021
34
Clinical significance of hypoalbuminemia in patients with scrub typhus complicated by acute kidney injury. 61
33630937 2021
35
Scrub typhus with secondary hemophagocytic lymphohistiocytosis in a 3-month-old child from a tertiary care hospital of Odisha. 61
33753698 2021
36
Follow-up investigation of antibody titers and diagnostic antibody cutoff values in patients with scrub typhus in South Korea. 61
33441087 2021
37
Prolonged coma in scrub typhus: consider non-convulsive status epilepticus. 61
33515451 2021
38
Scrub typhus mimicking the clinical course of infectious mononucleosis: a case report. 61
33442438 2021
39
Takotsubo Cardiomyopathy in Pediatric Scrub Typhus. 61
33452781 2021
40
Multisystem Inflammatory Syndrome in a Child with Scrub Typhus and Macrophage Activation Syndrome. 61
33787904 2021
41
Scrub Typhus-Associated Hemophagocytic Lymphohistiocytosis: Not a Rare Entity in Pediatric Age Group. 61
33547467 2021
42
Hemophagocytic Lymphohistiocytosis in a PICU of a Developing Economy: Clinical Profile, Intensive Care Needs, Outcome, and Predictors of Mortality. 61
33031348 2021
43
Scrub typhus in Chile. 61
33651874 2021
44
The Need for Geographic Location Specific Optical Density Cut-offs for IgM ELISA Serology to Diagnose Scrub Typhus in Children. 61
33452796 2021
45
Drug therapy in Pediatric Scrub Typhus - Is 'not Giving Azithromycin' a Risk Factor for PICU Admission? 61
33510538 2021
46
Comparative Efficacy of Doxycycline vs. Azithromycin in Pediatric Scrub Typhus. 61
32797390 2021
47
Is cerebrospinal fluid lactate useful in differentiating scrub typhus meningitis from aseptic, bacterial and tuberculous meningitis? 61
33259753 2021
48
Antibiotic Response to Pediatric Scrub Typhus in South India: Is Clinical Failure to Azithromycin to be Worried? 61
33684931 2021
49
Glossopharyngeal and Vagus Nerve Palsy in a Child With Scrub Typhus Meningitis. 61
33452783 2021
50
The Need for Geographic Location Specific Optical Density Cut-offs for IgM ELISA Serology to Diagnose Scrub Typhus in Children: Authors' Reply. 61
33452797 2021

Variations for Scrub Typhus

Expression for Scrub Typhus

Search GEO for disease gene expression data for Scrub Typhus.

Pathways for Scrub Typhus

Pathways related to Scrub Typhus according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 TNF TLR4 TLR2 LCN2 IL1B IL18
2
Show member pathways
13.43 TNF TLR4 TLR2 IL1B IL18 IL17A
3
Show member pathways
13.38 TNF LCN2 IL1B IL18 IL17A IL15
4
Show member pathways
13.24 TNF TLR4 TLR2 IL1B IL18 IL10
5
Show member pathways
12.9 TNF IL1B IL17A IL15 IL10 IFNG
6
Show member pathways
12.85 TNF TLR4 TLR2 IL1B IL18 IFNG
7
Show member pathways
12.77 TNF TLR4 TLR2 IL1B IL18 F3
8
Show member pathways
12.75 TNF TLR4 TLR2 IL1B IL18
9
Show member pathways
12.64 TNF IL1B IL18 IL17A IL10 IFNG
10
Show member pathways
12.64 TNF TLR4 TLR2 IL1B IL17A IL10
11
Show member pathways
12.63 TNF TLR4 TLR2 IL1B IL18 IL17A
12 12.59 TNF TLR2 IL1B IL17A IL10 IFNG
13 12.4 TNF TLR4 IL1B IL18
14
Show member pathways
12.4 TNF TLR2 LCN2 IL1B IL17A IFNG
15
Show member pathways
12.39 TNF TCN2 IL1B IFNG CRP
16
Show member pathways
12.32 TNF TLR4 TLR2 IL1B IL10 IFNG
17
Show member pathways
12.31 TNF TLR4 IL1B IFNG
18
Show member pathways
12.3 TNF IL1B IL18 IL17A IL15 IL10
19 12.26 TNF TLR4 IL1B IL18
20 12.26 TNF TLR4 TLR2 IL1B IL18 IL10
21
Show member pathways
12.25 TNF TLR4 TLR2 IL1B IFNG
22
Show member pathways
12.22 TNF TLR4 IL1B IFNG
23 12.21 TNF TLR4 TLR2 IFNG
24 12.15 TNF TLR4 IL1B IL18 IL10
25 12.06 TNF TLR4 IL1B IFNG
26 12.06 TNF LCN2 IL1B IL18 IL17A IL10
27 12.04 TNF IL15 IL10 IFNG
28 12 TNF TLR4 TLR2 IL1B IL10 IFNG
29
Show member pathways
11.94 TLR4 TLR2 IL1B IL17A IFNG
30 11.83 TNF TLR4 IL1B IL10
31 11.82 TNF IL1B IL10 IFNG
32 11.77 TNF IL1B IL18 IL17A IL15 IL10
33 11.76 TNF TLR4 TLR2 IL10
34 11.69 TNF TLR4 TLR2 IL1B IL18
35
Show member pathways
11.68 TNF IL1B IFNG
36 11.61 TNF IL1B IL18 IL10
37
Show member pathways
11.58 TNF IFNG HSPA4
38 11.56 TNF TLR4 TLR2 IL1B IL18 IFNG
39 11.55 TNF IL1B IFNG
40 11.53 TNF TLR4 TLR2 IL1B IL18 IL17A
41 11.51 TNF IL1B IFNG
42
Show member pathways
11.46 TNF IL15 IL10 IFNG
43 11.44 TNF TLR4 IL1B IL10
44 11.41 TNF IL1B IL18 IL10 IFNG IDO1
45 11.4 TNF TLR4 TLR2 IL1B IL18 IL10
46 11.29 TNF IL1B IL15 IL10 IFNG
47 11.27 TLR2 IL1B IL18 IFNG
48 11.24 TNF IL1B IL18 IL17A IL15 IFNG
49 11.18 TNF IL1B IL18
50
Show member pathways
11.11 TNF TLR4 TLR2 IL1B IL18 IL17A

GO Terms for Scrub Typhus

Cellular components related to Scrub Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TNF TCN2 LCN2 IL1B IL18 IL17A
2 cell surface GO:0009986 9.63 TNF TLR4 TLR2 IL15 HAVCR1 F3
3 extracellular space GO:0005615 9.4 TNF TCN2 LCN2 IL1B IL18 IL17A

Biological processes related to Scrub Typhus according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 10.02 TNF TLR4 LCN2 IL10
2 cell-cell signaling GO:0007267 10 IL1B IL18 IL17A IL15
3 response to lipopolysaccharide GO:0032496 10 TLR4 TLR2 IL1B IL10 IDO1
4 cytokine-mediated signaling pathway GO:0019221 10 TNF LCN2 IL1B IL18 IL17A IL10
5 cellular response to lipopolysaccharide GO:0071222 9.99 TNF TLR4 LCN2 IL1B IL10
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 TNF TLR4 TLR2 IL1B IL18
7 defense response to Gram-positive bacterium GO:0050830 9.95 TNF TLR2 IL17A CRP
8 positive regulation of tumor necrosis factor production GO:0032760 9.93 TLR4 TLR2 IL17A IFNG
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.91 TNF IL18 IL15 IFNG
10 positive regulation of interferon-gamma production GO:0032729 9.91 TNF TLR4 IL1B IL18
11 positive regulation of gene expression GO:0010628 9.91 TNF TLR4 TLR2 LCN2 IL1B IL18
12 positive regulation of JNK cascade GO:0046330 9.9 TNF TLR4 IL1B
13 regulation of insulin secretion GO:0050796 9.88 TNF IL1B IFNG
14 negative regulation of interleukin-6 production GO:0032715 9.88 TNF TLR4 IL10
15 cellular response to organic cyclic compound GO:0071407 9.88 TNF IL1B IL18
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.88 TNF TLR4 TLR2 IL1B IL18
17 positive regulation of interleukin-1 beta production GO:0032731 9.87 TNF TLR4 IL17A IFNG
18 positive regulation of cytokine production GO:0001819 9.85 TNF IL15 IL10 IFNG
19 microglial cell activation GO:0001774 9.84 TNF TLR2 IFNG
20 positive regulation of phagocytosis GO:0050766 9.84 TNF IL1B IL15 IFNG
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 TNF TLR4 IL1B IFNG
22 positive regulation of interleukin-8 production GO:0032757 9.83 TNF TLR4 TLR2 IL1B F3
23 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.82 TNF TLR4 IL17A
24 positive regulation of osteoclast differentiation GO:0045672 9.81 TNF IL17A IFNG
25 positive regulation of chemokine production GO:0032722 9.81 TNF TLR4 TLR2 IFNG
26 immune response GO:0006955 9.81 TNF TLR4 TLR2 IL1B IL18 IL17A
27 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.8 TLR4 TLR2 IFNG
28 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.8 TNF IL1B IFNG
29 positive regulation of interleukin-12 production GO:0032735 9.8 TLR4 TLR2 IL17A IFNG IDO1
30 positive regulation of interleukin-6 production GO:0032755 9.8 TNF TLR4 TLR2 IL1B IL17A IFNG
31 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.79 TNF IL1B IL10
32 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 TNF TLR4 TLR2 IL1B IL18
33 positive regulation of neuroinflammatory response GO:0150078 9.76 TNF IL1B IL18
34 I-kappaB phosphorylation GO:0007252 9.73 TLR4 TLR2
35 positive regulation of MHC class II biosynthetic process GO:0045348 9.73 TLR4 IL10 IFNG
36 negative regulation of amyloid-beta clearance GO:1900222 9.72 TNF IFNG
37 response to molecule of bacterial origin GO:0002237 9.72 TLR2 IL10
38 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.72 TNF TLR4
39 regulation of establishment of endothelial barrier GO:1903140 9.72 TNF IL1B
40 cellular response to lipoteichoic acid GO:0071223 9.71 TLR4 TLR2
41 T-helper 1 type immune response GO:0042088 9.71 TLR4 IL18
42 negative regulation of lipid storage GO:0010888 9.71 TNF CRP
43 endothelial cell apoptotic process GO:0072577 9.7 TNF IL10
44 positive regulation of natural killer cell proliferation GO:0032819 9.7 IL18 IL15
45 vascular endothelial growth factor production GO:0010573 9.69 TNF IL1B
46 positive regulation of tissue remodeling GO:0034105 9.69 IL18 IL15
47 negative regulation of cytokine production involved in immune response GO:0002719 9.69 TNF IL10
48 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.68 IL1B IL18
49 intestinal epithelial structure maintenance GO:0060729 9.68 TLR4 IL17A
50 type 2 immune response GO:0042092 9.68 IL18 IL10

Molecular functions related to Scrub Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 TNF IL1B IL18 IL17A IL15 IL10
2 lipopolysaccharide receptor activity GO:0001875 8.96 TLR4 TLR2

Sources for Scrub Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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