MCID: SCR008
MIFTS: 63

Scrub Typhus

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Scrub Typhus

MalaCards integrated aliases for Scrub Typhus:

Name: Scrub Typhus 12 60 56 3 45 15 17 74
Tsutsugamushi Disease 12 60
Tsutsugamushi Fever 12 60
Typhus Fever Due to Rickettsia Tsutsugamushi 12
Chigger-Borne Rickettsiosis 12
Mite-Borne Rickettsiosis 12
Scrub Mite-Borne Typhus 12
Chigger-Borne Typhus 12
Japanese River Fever 12
Mite-Borne Typhus 12
Tropical Typhus 12
Scrub Typhus 12
Tsutsugamushi 12
Kedani Fever 12

Characteristics:

Orphanet epidemiological data:

60
scrub typhus
Prevalence: 1-9/100000 (Korea, Republic of),1-9/1000000 (Japan); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 60  
Rare infectious diseases


Summaries for Scrub Typhus

CDC : 3 Typhus fevers are a group of diseases caused by bacteria that are spread to humans by fleas, lice, and chiggers. Typhus fevers include scrub typhus, murine typhus, and epidemic typhus. Chiggers spread scrub typhus, fleas spread murine typhus, and body lice spread epidemic typhus. The most common symptoms are fever, headaches, and sometimes rash.

MalaCards based summary : Scrub Typhus, also known as tsutsugamushi disease, is related to epidemic typhus and infantile liver failure syndrome 1. An important gene associated with Scrub Typhus is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and NF-KappaB Family Pathway. The drugs Doxycycline and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and heart, and related phenotypes are hyperhidrosis and fever

Disease Ontology : 12 A typhus that has material basis in Orientia tsutsugamushi, which is transmitted by trombiculid mites (Leptotrombidium deliense). The infection has symptom fever, has symptom headache, has symptom muscle pain, has symptom cough, has symptom maculopapular rash, has symptom eschar, has symptom splenomegaly and has symptom lymphadenopathy.

Wikipedia : 77 Scrub typhus or bush typhus is a form of typhus caused by the intracellular parasite Orientia... more...

Related Diseases for Scrub Typhus

Diseases related to Scrub Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 343)
# Related Disease Score Top Affiliating Genes
1 epidemic typhus 33.2 F3 GPT TCN2
2 infantile liver failure syndrome 1 31.2 GPT SLC17A5
3 transverse myelitis 31.1 IL10 TNF
4 hepatitis 30.9 GPT SLC17A5 TNF
5 poliomyelitis 30.6 IL10 TNF
6 respiratory failure 30.5 CRP F3 TNF
7 hepatitis a 30.3 GPT IL10 TNF
8 liver cirrhosis 30.2 F3 GPT SLC17A5
9 leptospirosis 30.2 CRP IL10 IL1B TLR2 TNF
10 meningitis 30.1 CRP IL10 IL1B TLR2 TNF
11 aseptic meningitis 30.1 IL10 IL1B TNF
12 hellp syndrome 30.0 F3 GPT SLC17A5
13 viral hepatitis 30.0 GPT SLC17A5 TLR2 TNF
14 q fever 29.9 IL10 IL1B TLR2 TLR4 TNF
15 endocarditis 29.8 CRP IL10 TLR2 TNF
16 typhoid fever 29.7 CRP IL1B TLR4 TNF
17 pericarditis 29.6 CRP IL1B TNF
18 melioidosis 29.6 IL10 TLR2 TLR4 TNF
19 bacterial meningitis 29.6 CRP IL10 IL1B TLR2 TNF
20 lyme disease 29.5 CRP IL1B TLR2 TNF
21 peritonitis 29.3 CRP IL10 IL1B TLR2 TNF
22 pneumonia 29.2 CRP IL10 IL1B TLR2 TLR4 TNF
23 myocardial infarction 28.7 CRP F3 IL10 IL1B TLR4 TNF
24 malaria 28.1 CRP F3 IDO1 IL10 IL1B TCN2
25 endemic typhus 10.7
26 acute respiratory distress syndrome 10.7
27 spotted fever 10.6
28 encephalitis 10.6
29 hemophagocytic lymphohistiocytosis 10.5
30 meningoencephalitis 10.5
31 pancreatitis 10.5
32 fatty liver disease, nonalcoholic 1 10.5 GPT SLC17A5
33 kwashiorkor 10.5 GPT SLC17A5
34 thrombocytopenia 10.4
35 guillain-barre syndrome 10.4
36 myocarditis 10.4
37 multicentric castleman disease 10.4 CRP IL10
38 compartment syndrome 10.4 SLC17A5 TNF
39 ischemic heart disease 10.4 CRP TNF
40 streptococcal meningitis 10.4 CRP TNF
41 relapsing fever 10.4 CRP TNF
42 louse-borne relapsing fever 10.4 CRP TNF
43 dengue virus 10.4
44 cholecystitis 10.4
45 myelitis 10.4
46 hypersensitivity reaction type iii disease 10.4 CRP TNF
47 diverticulitis 10.4 CRP TNF
48 tuberculous peritonitis 10.4 CRP TNF
49 post-transplant lymphoproliferative disease 10.4 IL10 TNF
50 autoimmune disease of eyes, ear, nose and throat 10.4 IL10 TNF

Graphical network of the top 20 diseases related to Scrub Typhus:



Diseases related to Scrub Typhus

Symptoms & Phenotypes for Scrub Typhus

Human phenotypes related to Scrub Typhus:

60 33 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperhidrosis 60 33 hallmark (90%) Very frequent (99-80%) HP:0000975
2 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
3 myalgia 60 33 hallmark (90%) Very frequent (99-80%) HP:0003326
4 skin rash 60 33 hallmark (90%) Very frequent (99-80%) HP:0000988
5 cough 60 33 hallmark (90%) Very frequent (99-80%) HP:0012735
6 lethargy 60 33 hallmark (90%) Very frequent (99-80%) HP:0001254
7 nausea and vomiting 60 33 frequent (33%) Frequent (79-30%) HP:0002017
8 hypotension 60 33 frequent (33%) Frequent (79-30%) HP:0002615
9 photophobia 60 33 frequent (33%) Frequent (79-30%) HP:0000613
10 abdominal pain 60 33 frequent (33%) Frequent (79-30%) HP:0002027
11 headache 60 33 frequent (33%) Frequent (79-30%) HP:0002315
12 macule 60 33 frequent (33%) Frequent (79-30%) HP:0012733
13 lymphadenopathy 60 33 frequent (33%) Frequent (79-30%) HP:0002716
14 gangrene 60 33 frequent (33%) Frequent (79-30%) HP:0100758
15 anterior uveitis 60 33 frequent (33%) Frequent (79-30%) HP:0012122
16 seizures 60 33 occasional (7.5%) Occasional (29-5%) HP:0001250
17 tremor 60 33 occasional (7.5%) Occasional (29-5%) HP:0001337
18 encephalitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0002383
19 splenomegaly 60 33 occasional (7.5%) Occasional (29-5%) HP:0001744
20 renal insufficiency 60 33 occasional (7.5%) Occasional (29-5%) HP:0000083
21 dyspnea 60 33 occasional (7.5%) Occasional (29-5%) HP:0002094
22 abnormal bleeding 60 33 occasional (7.5%) Occasional (29-5%) HP:0001892
23 myocarditis 60 33 occasional (7.5%) Occasional (29-5%) HP:0012819
24 meningitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0001287
25 restrictive ventilatory defect 60 33 occasional (7.5%) Occasional (29-5%) HP:0002091
26 behavioral abnormality 60 Occasional (29-5%)
27 reduced consciousness/confusion 60 Very frequent (99-80%)

MGI Mouse Phenotypes related to Scrub Typhus:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 CRP F3 IDO1 IL10 IL1B TLR2
2 homeostasis/metabolism MP:0005376 9.97 CRP F3 IDO1 IL10 IL1B SLC17A5
3 immune system MP:0005387 9.86 CRP F3 IDO1 IL10 IL1B TLR2
4 integument MP:0010771 9.63 F3 IL10 IL1B TLR2 TLR4 TNF
5 muscle MP:0005369 9.43 F3 IDO1 IL10 TLR2 TLR4 TNF
6 neoplasm MP:0002006 9.1 F3 IL10 IL1B TLR2 TLR4 TNF

Drugs & Therapeutics for Scrub Typhus

Drugs for Scrub Typhus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 564-25-0 54671203
2
Azithromycin Approved Phase 4 83905-01-5 447043 55185
3 Antitubercular Agents Phase 4,Not Applicable
4 Anti-Bacterial Agents Phase 4,Phase 3,Not Applicable
5 Antiprotozoal Agents Phase 4,Phase 3,Not Applicable
6 Antibiotics, Antitubercular Phase 4,Not Applicable
7 Antiparasitic Agents Phase 4,Phase 3,Not Applicable
8 Antimalarials Phase 4,Phase 3,Not Applicable
9 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
10
Telithromycin Approved Phase 3 191114-48-4 70789201 5462516
11
Rifampicin Approved Not Applicable 13292-46-1 5381226 5458213
12
carbamide peroxide Approved 124-43-6
13
Ethanol Approved 64-17-5 702
14 Cytochrome P-450 CYP3A Inducers Not Applicable
15 Nucleic Acid Synthesis Inhibitors Not Applicable
16 Vaccines
17 Immunoglobulins
18 Antibodies

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Scrub Typhus Antibiotic Resistance Trial Recruiting NCT03083197 Phase 4 Doxycycline 7 days;Doxycycline 3 days;Azithromycin 3 days
2 Controlled Trial: 5-day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00351182 Phase 3 Telithromycin;Doxycycline
3 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
4 Scrub Typhus Pediatric Immunology Study Completed NCT02398162
5 Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00568711 Not Applicable doxycycline;rifampin
6 Causes of Fever in Bangladeshi Patients Completed NCT02339259
7 Scrub Typhus Infection Induced Cardiovascular Disease Recruiting NCT03274869
8 Eschar Investigations in Scrub Typhus Recruiting NCT02915861
9 Scrub Typhus RDT Study Active, not recruiting NCT03269266
10 The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents Active, not recruiting NCT02876367
11 Rickettsiae in Myanmar Not yet recruiting NCT03847870

Search NIH Clinical Center for Scrub Typhus

Cochrane evidence based reviews: scrub typhus

Genetic Tests for Scrub Typhus

Anatomical Context for Scrub Typhus

MalaCards organs/tissues related to Scrub Typhus:

42
Testes, Kidney, Heart, Skin, Monocytes, T Cells, Brain

Publications for Scrub Typhus

Articles related to Scrub Typhus:

(show top 50) (show all 1197)
# Title Authors Year
1
Guillain-Barre syndrome: a rare complication of leptospirosis and scrub typhus co-infection. ( 30895887 )
2019
2
Hemophagocytic lymphohistiocytosis with neurological manifestations in an infant with scrub typhus: a rare fatal occurrence. ( 30360694 )
2019
3
Recent Increase of Human Granulocytic Anaplasmosis and Co-Infection with Scrub Typhus or Korean Hemorrhagic Fever with Renal Syndrome in Korea. ( 30914905 )
2019
4
Long-Segment Myelitis, Meningoencephalitis, and Axonal Polyneuropathy in a Case of Scrub Typhus. ( 31007446 )
2019
5
Case Report: Scrub Typhus and Q Fever Coinfection. ( 30915946 )
2019
6
Characteristics of scrub typhus, murine typhus, and Q fever among elderly patients: Prolonged prothrombin time as a predictor for severity. ( 28709838 )
2019
7
Ocular Flutter in Scrub Typhus. ( 30266504 )
2019
8
Pulmonary Artery Thrombosis Associated with Scrub Typhus. ( 30941942 )
2019
9
Scrub typhus infection, not a benign disease: an experience from a tertiary care center in Northern India. ( 30957085 )
2019
10
Misdiagnosis of scrub typhus complicated by hemophagocytic syndrome. ( 30971222 )
2019
11
Evaluation of loop-mediated isothermal amplification assay for detection of scrub typhus in patients with acute febrile illness presenting to a Tertiary Care Center in Puducherry, India. ( 30983808 )
2019
12
Scrub Typhus-Associated Opsoclonus: Clinical Course and Longitudinal Outcomes in an Indian Cohort. ( 31007425 )
2019
13
Clinicoepidemiologic characteristics of scrub typhus and murine typhus: A multi-center study in southern Taiwan. ( 31088776 )
2019
14
Scrub typhus caused by Shimokoshi type Orientia tsutsugamushi showing variant 56-kDa type-specific antigen gene sequence in Tohoku region, Japan. ( 31087695 )
2019
15
Profile of Pediatric Scrub Typhus in Odisha, India. ( 31064899 )
2019
16
Scrub typhus: Overview of demographic variables, clinical profile, and diagnostic issues in the sub-Himalayan region of India and its comparison to other Indian and Asian studies. ( 31041272 )
2019
17
Deforestation Increases the Risk of Scrub Typhus in Korea. ( 31035715 )
2019
18
Clinical and Epidemiological Patterns of Scrub Typhus, an Emerging Disease in Bhutan. ( 30934849 )
2019
19
Indicators of severe prognosis of scrub typhus: prognostic factors of scrub typhus severity. ( 30909868 )
2019
20
Evaluation of Th1 and Th2 immune response in clinical and sub-clinical scrub typhus infection. ( 30904436 )
2019
21
Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015-2017. ( 30882318 )
2019
22
Clinical Characteristics and Outcome of Children Hospitalized With Scrub Typhus in an Area of Endemicity. ( 30864670 )
2019
23
Determination of Optimal Diagnostic Cut-Offs for the Naval Medical Research Center Scrub Typhus IgM ELISA in Chiang Rai, Thailand. ( 30860022 )
2019
24
Scrub Typhus in Continental Chile, 2016-20181. ( 30835200 )
2019
25
Hospitalisations and outpatient visits for undifferentiated fever attributable to scrub typhus in rural South India: Retrospective cohort and nested case-control study. ( 30802243 )
2019
26
Dissemination of Orientia tsutsugamushi in a Case of Scrub Typhus. ( 30795827 )
2019
27
Severe fever with thrombocytopenia syndrome: comparison with scrub typhus and clinical diagnostic prediction. ( 30782137 )
2019
28
Scrub Typhus and Abnormal Electrocardiography. ( 30734694 )
2019
29
Epidemiology, Risk Factors and Seasonal Variation of Scrub Typhus Fever in Central Nepal. ( 30717408 )
2019
30
The validity of diagnostic cut-offs for commercial and in-house scrub typhus IgM and IgG ELISAs: A review of the evidence. ( 30716070 )
2019
31
Scrub typhus strikes back: Are we ready? ( 30705472 )
2019
32
Scrub typhus risk in travelers to southern Chile. ( 30639781 )
2019
33
Evaluation of Enzyme-Linked Immunosorbent Assay Using Recombinant 56-kDa Type-Specific Antigens Derived from Multiple Orientia tsutsugamushi Strains for Detection of Scrub Typhus Infection. ( 30526730 )
2019
34
Geometric morphometrics of the scutum for differentiation of trombiculid mites within the genus Walchia (Acariformes: Prostigmata: Trombiculidae), a probable vector of scrub typhus. ( 30501981 )
2019
35
Targeting metabolic pathways proteins of Orientia tsutsugamushi using combined hierarchical approach to combat scrub typhus. ( 30343521 )
2019
36
Clinical characteristics and effective treatments of scrub typhus-associated hemophagocytic lymphohistiocytosis in children. ( 30581619 )
2019
37
Scrub Typhus Complicated by ARDS, Myocarditis, and Encephalitis Imported to Oman from Nepal. ( 31110635 )
2019
38
Clinical Profile and Therapeutic Response of Scrub Typhus in Children: A Recent Trend from Eastern India. ( 29800384 )
2019
39
Pseudothrombocytopenia and Usefulness of Platelet Aggregates in Peripheral Smear in the Diagnosis of Scrub Typhus. ( 29858982 )
2019
40
Laboratory-acquired Scrub Typhus and Murine Typhus Infections: The Argument for a Risk-based Approach to Biosafety Requirements for Orientia tsutsugamushi and Rickettsia typhi Laboratory Activities. ( 30107504 )
2019
41
Time spent in an endemic area is a crucial clue to diagnose scrub typhus without eschar. ( 30144135 )
2019
42
Predictors of acute myocarditis in complicated scrub typhus: an endemic province in the Republic of Korea. ( 28226202 )
2018
43
Acute transverse myelitis following scrub typhus: A case report and review of the literature. ( 29350608 )
2018
44
Scrub Typhus Meningitis Versus Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396931 )
2018
45
Comparison of Scrub Typhus Meningitis with Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396933 )
2018
46
Scrub typhus and depression: a nationwide cohort analysis. ( 30509305 )
2018
47
Occurrence of Orientia tsutsugamushi, the Etiological Agent of Scrub Typhus in Animal Hosts and Mite Vectors in Areas Reporting Human Cases of Acute Encephalitis Syndrome in the Gorakhpur Region of Uttar Pradesh, India. ( 30016222 )
2018
48
Acute encephalopathy with biphasic seizures and late diffusion restriction in scrub typhus encephalitis. ( 30039462 )
2018
49
Mild encephalitis/encephalopathy with reversible splenial lesion complicated with scrub typhus. ( 30054749 )
2018
50
Epididymo-Orchitis in Scrub Typhus. ( 29675739 )
2018

Variations for Scrub Typhus

Expression for Scrub Typhus

Search GEO for disease gene expression data for Scrub Typhus.

Pathways for Scrub Typhus

Pathways related to Scrub Typhus according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.94 IL10 IL1B TLR2 TLR4 TNF
2
Show member pathways
12.56 IL1B TLR2 TLR4 TNF
3
Show member pathways
12.48 IL1B TLR2 TLR4 TNF
4
Show member pathways
12.47 IL10 IL1B TLR2 TLR4 TNF
5 12.42 IDO1 IL10 IL1B TLR2 TNF
6
Show member pathways
12.22 CRP IL1B TCN2 TNF
7 12.16 TLR2 TLR4 TNF
8
Show member pathways
12.14 TLR2 TLR4 TNF
9
Show member pathways
12.13 IL10 IL1B TLR2 TLR4 TNF
10
Show member pathways
12.11 F3 IL1B TLR2 TNF
11
Show member pathways
12.09 IL10 IL1B TNF
12
Show member pathways
12.08 IL1B TLR4 TNF
13
Show member pathways
12.08 IL1B TLR2 TLR4 TNF
14 12.08 IL10 IL1B TLR2 TLR4 TNF
15 12.06 TLR2 TLR4 TNF
16 12.05 IL10 IL1B TNF
17
Show member pathways
11.93 IL1B TLR2 TLR4 TNF
18
Show member pathways
11.91 IL1B TLR2 TLR4
19 11.89 IL1B TLR4 TNF
20 11.86 IL10 IL1B TNF
21
Show member pathways
11.83 IL10 IL1B TLR2 TLR4 TNF
22 11.8 F3 IL1B TNF
23 11.79 IL1B TLR4 TNF
24 11.75 IL1B TLR2 TLR4 TNF
25 11.68 IL10 IL1B TNF
26 11.66 IL10 IL1B TLR4 TNF
27 11.64 IL10 IL1B TNF
28 11.62 IL10 IL1B TNF
29 11.45 IL1B TLR2 TLR4 TNF
30 11.44 IL10 IL1B TNF
31 11.35 IL1B TLR2 TLR4 TNF
32 11.34 IL10 IL1B TLR2 TLR4 TNF
33 11.19 IL10 IL1B TNF
34 11.13 IDO1 IL10 IL1B TNF
35 11.09 IL10 IL1B TNF
36 11.07 IL1B TLR2
37 11 IL1B TNF
38 11 IL10 IL1B TLR4 TNF
39 10.93 CRP TNF
40 10.85 IL1B TNF
41 10.71 IL10 IL1B TLR2 TLR4 TNF

GO Terms for Scrub Typhus

Cellular components related to Scrub Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CRP F3 GPT IL10 IL1B TCN2

Biological processes related to Scrub Typhus according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.98 IL10 IL1B TLR2 TLR4 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.94 F3 IL10 IL1B TNF
3 positive regulation of gene expression GO:0010628 9.92 CRP IL1B TLR2 TLR4 TNF
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.89 IL1B TLR4 TNF
5 activation of MAPK activity GO:0000187 9.86 IL1B TLR4 TNF
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.85 IL10 IL1B TNF
7 defense response to Gram-positive bacterium GO:0050830 9.85 CRP TLR2 TNF
8 cellular response to lipopolysaccharide GO:0071222 9.84 IL10 IL1B TLR4 TNF
9 positive regulation of JNK cascade GO:0046330 9.83 IL1B TLR4 TNF
10 positive regulation of inflammatory response GO:0050729 9.81 TLR2 TLR4 TNF
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 IL1B TLR2 TLR4 TNF
12 positive regulation of interferon-gamma production GO:0032729 9.75 IL1B TLR4 TNF
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.74 IL1B TLR4 TNF
14 negative regulation of interferon-gamma production GO:0032689 9.72 IL10 TLR4
15 positive regulation of cytokine secretion GO:0050715 9.72 IL10 TNF
16 regulation of synapse organization GO:0050807 9.72 IL10 TNF
17 positive regulation of interferon-beta production GO:0032728 9.71 TLR2 TLR4
18 negative regulation of neurogenesis GO:0050768 9.71 IL1B TNF
19 positive regulation of interleukin-10 production GO:0032733 9.71 TLR2 TLR4
20 microglial cell activation GO:0001774 9.71 TLR2 TNF
21 negative regulation of lipid catabolic process GO:0050995 9.7 IL1B TNF
22 positive regulation of glial cell proliferation GO:0060252 9.7 IL1B TNF
23 positive regulation of macrophage activation GO:0043032 9.7 IL10 TLR4
24 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.7 IL1B TNF
25 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 IL1B TNF
26 negative regulation of growth of symbiont in host GO:0044130 9.69 IL10 TNF
27 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.68 TLR2 TLR4
28 regulation of cytokine secretion GO:0050707 9.68 TLR2 TLR4
29 I-kappaB phosphorylation GO:0007252 9.68 TLR2 TLR4
30 response to molecule of bacterial origin GO:0002237 9.67 IL10 TLR2
31 cellular response to lipoteichoic acid GO:0071223 9.67 TLR2 TLR4
32 positive regulation of interleukin-6 production GO:0032755 9.67 IL1B TLR2 TLR4 TNF
33 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.66 TLR4 TNF
34 negative regulation of lipid storage GO:0010888 9.66 CRP TNF
35 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
36 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B TNF
37 negative regulation of interleukin-6 production GO:0032715 9.65 IL10 TLR4 TNF
38 response to lipopolysaccharide GO:0032496 9.65 IDO1 IL10 IL1B TLR2 TLR4
39 positive regulation of MHC class II biosynthetic process GO:0045348 9.63 IL10 TLR4
40 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
41 positive regulation of interleukin-12 production GO:0032735 9.63 IDO1 TLR2 TLR4
42 negative regulation of cytokine secretion involved in immune response GO:0002740 9.62 IL10 TNF
43 positive regulation of neuroinflammatory response GO:0150078 9.62 IL1B TNF
44 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.62 IL1B TLR2 TLR4 TNF
45 response to glucocorticoid GO:0051384 9.61 IL10 TNF
46 positive regulation of fever generation GO:0031622 9.61 IL1B TNF
47 positive regulation of chemokine production GO:0032722 9.61 TLR2 TLR4 TNF
48 sequestering of triglyceride GO:0030730 9.59 IL1B TNF
49 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL10 IL1B TNF
50 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.56 IL1B TNF

Molecular functions related to Scrub Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Scrub Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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