MCID: SCR008
MIFTS: 56

Scrub Typhus

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Scrub Typhus

MalaCards integrated aliases for Scrub Typhus:

Name: Scrub Typhus 12 59 55 44 15 17 72
Typhus Fever Due to Rickettsia Tsutsugamushi 12 33
Tsutsugamushi Disease 12 59
Tsutsugamushi Fever 12 59
Chigger-Borne Rickettsiosis 12
Mite-Borne Rickettsiosis 12
Scrub Mite-Borne Typhus 12
Chigger-Borne Typhus 12
Japanese River Fever 12
Mite-Borne Typhus 12
Tropical Typhus 12
Scrub Typhus 12
Tsutsugamushi 12
Kedani Fever 12

Characteristics:

Orphanet epidemiological data:

59
scrub typhus
Prevalence: 1-9/100000 (Korea, Republic of),1-9/1000000 (Japan); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:13371
ICD9CM 35 081.2
MeSH 44 D012612
SNOMED-CT 68 73911003
ICD10 33 A75.3
MESH via Orphanet 45 D012612
ICD10 via Orphanet 34 A75.3
UMLS via Orphanet 73 C0036472
Orphanet 59 ORPHA83317
UMLS 72 C0036472

Summaries for Scrub Typhus

Disease Ontology : 12 A typhus that has material basis in Orientia tsutsugamushi, which is transmitted by trombiculid mites (Leptotrombidium deliense). The infection has symptom fever, has symptom headache, has symptom muscle pain, has symptom cough, has symptom maculopapular rash, has symptom eschar, has symptom splenomegaly and has symptom lymphadenopathy.

MalaCards based summary : Scrub Typhus, also known as typhus fever due to rickettsia tsutsugamushi, is related to epidemic typhus and vasculitis. An important gene associated with Scrub Typhus is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and NF-KappaB Family Pathway. The drugs Doxycycline and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and liver, and related phenotypes are hyperhidrosis and fever

Wikipedia : 75 Scrub typhus or bush typhus is a form of typhus caused by the intracellular parasite Orientia... more...

Related Diseases for Scrub Typhus

Diseases related to Scrub Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 467)
# Related Disease Score Top Affiliating Genes
1 epidemic typhus 32.7 TCN2 GPT F3
2 vasculitis 31.3 TNF CRP CD40LG
3 spotted fever 31.3 TNF IL10 IFNG
4 transverse myelitis 31.1 TNF IL10
5 hepatitis 31.0 TNF SLC17A5 GPT
6 pulmonary edema 31.0 TNF IL10 CRP
7 hemophagocytic lymphohistiocytosis 30.9 TNF IL10 IFNG
8 aseptic meningitis 30.9 TNF IL10 IFNG
9 appendicitis 30.8 TNF IL10 CRP
10 respiratory failure 30.8 TNF F3 CRP
11 rocky mountain spotted fever 30.5 SLC17A5 F3
12 peritonitis 30.5 TNF TLR2 IL10 CRP
13 typhoid fever 30.4 TNF TLR4 IFNG CRP
14 haemophilus influenzae 30.4 TNF TLR2
15 leptospirosis 30.4 TNF TLR2 IL10 IFNG CRP
16 viral hepatitis 30.4 TNF TLR2 SLC17A5 GPT
17 bacterial meningitis 30.4 TNF TLR2 IL10 CRP
18 african tick-bite fever 30.4 IFNG CD40LG
19 lung disease 30.3 TNF TLR2 IL10
20 pulmonary disease, chronic obstructive 30.3 TNF TLR2 CRP
21 cerebrovascular disease 30.2 TNF TLR4 CRP
22 pericarditis 30.2 TNF IFNG CRP
23 purpura 30.2 TNF F3 CRP
24 poliomyelitis 30.2 TNF IL10 IFNG
25 human immunodeficiency virus infectious disease 30.2 TNF IL10 IFNG
26 meningitis 30.2 TNF TLR2 IL10 IFNG CRP
27 infective endocarditis 30.1 TNF TLR2 CRP
28 pyelonephritis 30.1 TNF TLR4 IL10 CRP
29 hepatitis a 30.1 TNF IL10 IFNG GPT
30 dermatitis, atopic 30.1 TNF IL10 IFNG
31 hellp syndrome 29.9 SLC17A5 GPT F3
32 q fever 29.9 TNF TLR4 TLR2 IL10 IFNG
33 bacterial sepsis 29.9 TNF TLR4 IL10 CRP
34 toxic shock syndrome 29.9 TNF TLR4 TLR2 IL10 IFNG
35 hepatitis e 29.8 TNF IFNG GPT CD40LG
36 reactive arthritis 29.8 TNF IL10 IFNG CRP
37 analbuminemia 29.8 SLC17A5 GPT F3 CRP
38 lymphadenitis 29.8 TNF TLR4 IL10 IFNG
39 nervous system disease 29.8 TNF IL10 IFNG CRP
40 otitis media 29.8 TNF TLR4 TLR2 IL10
41 autoimmune disease 29.7 TNF IL10 IFNG CD40LG
42 lyme disease 29.7 TNF TLR2 CRP CD40LG
43 endocarditis 29.7 TNF TLR2 IL10 CRP
44 trypanosomiasis 29.7 TNF TLR2 IL10 IFNG
45 pulmonary tuberculosis 29.7 TNF TLR2 IL10 IFNG
46 liver cirrhosis 29.6 SLC17A5 GPT F3
47 demyelinating disease 29.5 TNF IL10 IFNG CD40LG
48 pneumonia 29.0 TNF TLR4 TLR2 IL10 CRP CD40LG
49 bacterial infectious disease 28.8 TNF TLR4 TLR2 IL10 IFNG CRP
50 chlamydia 28.8 TNF TLR4 TLR2 IL10 IFNG CRP

Graphical network of the top 20 diseases related to Scrub Typhus:



Diseases related to Scrub Typhus

Symptoms & Phenotypes for Scrub Typhus

Human phenotypes related to Scrub Typhus:

59 32 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperhidrosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0000975
2 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
3 skin rash 59 32 hallmark (90%) Very frequent (99-80%) HP:0000988
4 myalgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0003326
5 cough 59 32 hallmark (90%) Very frequent (99-80%) HP:0012735
6 lethargy 59 32 hallmark (90%) Very frequent (99-80%) HP:0001254
7 nausea and vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002017
8 hypotension 59 32 frequent (33%) Frequent (79-30%) HP:0002615
9 photophobia 59 32 frequent (33%) Frequent (79-30%) HP:0000613
10 abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002027
11 macule 59 32 frequent (33%) Frequent (79-30%) HP:0012733
12 gangrene 59 32 frequent (33%) Frequent (79-30%) HP:0100758
13 headache 59 32 frequent (33%) Frequent (79-30%) HP:0002315
14 lymphadenopathy 59 32 frequent (33%) Frequent (79-30%) HP:0002716
15 anterior uveitis 59 32 frequent (33%) Frequent (79-30%) HP:0012122
16 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
17 tremor 59 32 occasional (7.5%) Occasional (29-5%) HP:0001337
18 encephalitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002383
19 splenomegaly 59 32 occasional (7.5%) Occasional (29-5%) HP:0001744
20 renal insufficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0000083
21 dyspnea 59 32 occasional (7.5%) Occasional (29-5%) HP:0002094
22 abnormal bleeding 59 32 occasional (7.5%) Occasional (29-5%) HP:0001892
23 restrictive ventilatory defect 59 32 occasional (7.5%) Occasional (29-5%) HP:0002091
24 myocarditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0012819
25 meningitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001287
26 behavioral abnormality 59 Occasional (29-5%)
27 reduced consciousness/confusion 59 Very frequent (99-80%)

MGI Mouse Phenotypes related to Scrub Typhus:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.11 CD40LG CRP F3 IFNG IL10 SLC17A5
2 cardiovascular system MP:0005385 10.1 CD40LG CRP F3 IFNG IL10 TLR2
3 cellular MP:0005384 10.08 CD40LG F3 IFNG IL10 SLC17A5 TLR2
4 immune system MP:0005387 10.03 CD40LG CRP F3 IFNG IL10 TLR2
5 integument MP:0010771 9.95 CD40LG F3 IFNG IL10 TLR2 TLR4
6 nervous system MP:0003631 9.86 CD40LG F3 IFNG IL10 SLC17A5 TLR2
7 muscle MP:0005369 9.85 F3 IFNG IL10 TLR2 TLR4 TNF
8 neoplasm MP:0002006 9.8 F3 IFNG IL10 TLR2 TLR4 TNF
9 respiratory system MP:0005388 9.63 F3 IFNG IL10 TLR2 TLR4 TNF
10 skeleton MP:0005390 9.5 CD40LG GPT IFNG IL10 TLR2 TLR4
11 vision/eye MP:0005391 9.1 F3 IFNG IL10 SLC17A5 TLR4 TNF

Drugs & Therapeutics for Scrub Typhus

Drugs for Scrub Typhus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2
Azithromycin Approved Phase 4 83905-01-5 447043 55185
3 Anti-Bacterial Agents Phase 4
4 Anti-Infective Agents Phase 4
5 Antibiotics, Antitubercular Phase 4
6 Antitubercular Agents Phase 4
7 Antimalarials Phase 4
8 Antiparasitic Agents Phase 4
9 Antiprotozoal Agents Phase 4
10
Telithromycin Approved Phase 3 191114-48-4 5462516 70789201
11
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
12
Sulfamethoxazole Approved Phase 3 723-46-6 5329
13 Renal Agents Phase 3
14 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
15 Anti-Infective Agents, Urinary Phase 3
16
Rifampicin Approved 13292-46-1 5381226 5458213
17
Ethanol Approved 64-17-5 702
18
carbamide peroxide Approved 124-43-6
19 Cytochrome P-450 CYP3A Inducers
20 Cytochrome P-450 Enzyme Inducers
21 Nucleic Acid Synthesis Inhibitors
22 Vaccines
23 Antibodies
24 Immunoglobulins

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 The Scrub Typhus Antibiotic Resistance Trial (START) Comparing Doxycycline and Azithromycin Treatment Modalities in Areas of Reported Antimicrobial Resistance for Scrub Typhus Recruiting NCT03083197 Phase 4 Doxycycline 7 days;Doxycycline 3 days;Azithromycin 3 days
2 Phase 3 Study of Controlled Trial: 5-day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00351182 Phase 3 Telithromycin;Doxycycline
3 Parallel Group, Double Blinded, 1:1, Randomized Controlled Phase III Trial of Co-trimoxazole Versus Azithromycin for the Treatment of Undifferentiated Fever In Nepal Recruiting NCT02773407 Phase 3 Azithromycin;Co-trimoxazole
4 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
5 Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00568711 doxycycline;rifampin
6 The Natural Immune Response In Pediatric Scrub Typhus In Chiangrai Completed NCT02398162
7 Rickettsial Disease in Febrile Hospitalised Patients in a Tertiary Referral Hospital in Bangladesh Completed NCT02339259
8 Indian Intensive Care Case Mix and Practice Patterns Study Completed NCT01384929
9 Prediction and Early Diagnosis for Cardiovascular Disease Complicated by Scrub Typhus Infection Recruiting NCT03274869
10 Eschar Investigations to Improve Diagnostics, Understand Early Immune Responses and Characterize Strains for Vaccines in Scrub Typhus Recruiting NCT02915861
11 A Multicentre Observational Study to Describe the Prevalence of Scrub Typhus Defined as a Positive Rapid Diagnostic Test Among Selected Patients Presenting With Fever to Clinics in Myanmar Active, not recruiting NCT03269266
12 The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents Active, not recruiting NCT02876367
13 Background Seroprevalence of Rickettsial Infections in Myanmar Not yet recruiting NCT03847870

Search NIH Clinical Center for Scrub Typhus

Cochrane evidence based reviews: scrub typhus

Genetic Tests for Scrub Typhus

Anatomical Context for Scrub Typhus

MalaCards organs/tissues related to Scrub Typhus:

41
Testes, Kidney, Liver, T Cells, Skin, Endothelial, Brain

Publications for Scrub Typhus

Articles related to Scrub Typhus:

(show top 50) (show all 1705)
# Title Authors PMID Year
1
Does IL-17 play a role in hepatic dysfunction of scrub typhus patients? 9 38
19485773 2010
2
The difference in clinical characteristics between acute Q fever and scrub typhus in southern Taiwan. 9 38
18977677 2009
3
Comparison of indirect immunofluorescence assays for diagnosis of scrub typhus and murine typhus using venous blood and finger prick filter paper blood spots. 9 38
19407134 2009
4
Hepatic dysfunction in pediatric scrub typhus: role of liver function test in diagnosis and marker of disease severity. 9 38
18181321 2007
5
Scrub typhus among hospitalised patients with febrile illness in South India: magnitude and clinical predictors. 9 38
16368461 2006
6
Evaluation of an immunoglobulin M capture enzyme-linked immunosorbent assay for diagnosis of Orientia tsutsugamushi infection. 9 38
12738637 2003
7
Early diagnosis of scrub typhus with a rapid flow assay using recombinant major outer membrane protein antigen (r56) of Orientia tsutsugamushi. 9 38
11238230 2001
8
Serological reactivity of sera from scrub typhus patients against Weil-Felix test antigens. 9 38
8133798 1993
9
Case Report: Coinfection with Rickettsia monacensis and Orientia tsutsugamushi. 38
31219004 2019
10
Serologic Evidence for Orientia Exposure in the Democratic Republic of Sao Tome and Principe. 38
31407963 2019
11
Quantitative Serodiagnosis of Scrub Typhus Using Surface-Enhanced Raman Scattering-Based Lateral Flow Assay Platforms. 38
31356055 2019
12
High Seroprevalence of Mycoplasma pneumoniae and Chlamydia pneumoniae among Scrub Typhus Patients in South Korea. 38
31436153 2019
13
Development of multiplex PCR for neglected infectious diseases. 38
31283768 2019
14
The epidemiology and clinical features of rickettsial diseases in North Queensland, Australia: Implications for patient identification and management. 38
31318873 2019
15
Assessment of a Sensitive qPCR Assay Targeting a Multiple-Copy Gene to Detect Orientia tsutsugamushi DNA. 38
31370347 2019
16
Genetic diversity of Orientia tsutsugamushi strains from patients in north India. 38
31096051 2019
17
Scrub typhus caused by Shimokoshi type Orientia tsutsugamushi showing variant 56-kDa type-specific antigen gene sequence in Tohoku region, Japan. 38
31087695 2019
18
Risk factors for acquisition of scrub typhus in children admitted to a tertiary centre and its surrounding districts in South India: a case control study. 38
31349809 2019
19
Diversity of infectious aetiologies of acute undifferentiated febrile illnesses in south and Southeast Asia: a systematic review. 38
31272417 2019
20
Liver transplantation for Acute Liver Failure due to Dengue fever: first successful reported case worldwide. 38
31330052 2019
21
Dengue, chikungunya, and scrub typhus are important etiologies of non-malarial febrile illness in Rourkela, Odisha, India. 38
31269906 2019
22
Association of Scrub Typhus With the Risk of Autoimmune Diseases: A Population-Based Cohort Study. 38
31140560 2019
23
Dengue virus is an under-recognised causative agent of acute encephalitis syndrome (AES): Results from a four year AES surveillance study of Japanese encephalitis in selected states of India. 38
30641206 2019
24
Evaluation of Th1 and Th2 immune response in clinical and sub-clinical scrub typhus infection. 38
30904436 2019
25
Guillain-Barre syndrome: a rare complication of leptospirosis and scrub typhus co-infection. 38
30895887 2019
26
Clinical Profile and Predictors of Outcome of Pediatric Acute Respiratory Distress Syndrome in a PICU: A Prospective Observational Study. 38
31166289 2019
27
History of Tsutsugamushi Disease in Korea. 38
31271001 2019
28
Evaluation of scrub typhus diagnosis in China: analysis of nationwide surveillance data from 2006 to 2016. 38
31253202 2019
29
Marked elevation of serum lipase in scrub typhus without pancreatitis: a report of three cases. 38
31208290 2019
30
Distinguishing scrub typhus-related deltoid paralysis from cervical spondylosis in an elderly patient: a case report. 38
31154558 2019
31
Scrub Typhus in Continental Chile, 2016-20181. 38
30835200 2019
32
Clinical and Laboratory Predictors associated with Complicated Scrub Typhus. 38
31270995 2019
33
Case Report: Scrub Typhus and Q Fever Coinfection. 38
30915946 2019
34
Scrub typhus risk in travelers to southern Chile. 38
30639781 2019
35
Scrub Typhus Complicated by ARDS, Myocarditis, and Encephalitis Imported to Oman from Nepal. 38
31110635 2019
36
Re-emergence of scrub typhus in Zhejiang Province, southern China: A 45-year population-based surveillance study. 38
31125615 2019
37
Determination of Optimal Diagnostic Cut-Offs for the Naval Medical Research Center Scrub Typhus IgM ELISA in Chiang Rai, Thailand. 38
30860022 2019
38
Origins, Importance and Genetic Stability of the Prototype Strains Gilliam, Karp and Kato of Orientia tsutsugamushi. 38
31052283 2019
39
Survey of Rickettsia spp. and Orientia tsutsugamushi Pathogens Found in Animal Vectors (Ticks, Fleas, Chiggers) in Bangkaew District, Phatthalung Province, Thailand. 38
31104409 2019
40
Identification of B- and T-cell epitopes on HtrA protein of Orientia tsutsugamushi. 38
30320912 2019
41
Time spent in an endemic area is a crucial clue to diagnose scrub typhus without eschar. 38
30144135 2019
42
Laboratory-acquired Scrub Typhus and Murine Typhus Infections: The Argument for a Risk-based Approach to Biosafety Requirements for Orientia tsutsugamushi and Rickettsia typhi Laboratory Activities. 38
30107504 2019
43
Clinical Profile and Therapeutic Response of Scrub Typhus in Children: A Recent Trend from Eastern India. 38
29800384 2019
44
Scrub Typhus-Associated Opsoclonus: Clinical Course and Longitudinal Outcomes in an Indian Cohort. 38
31007425 2019
45
Long-Segment Myelitis, Meningoencephalitis, and Axonal Polyneuropathy in a Case of Scrub Typhus. 38
31007446 2019
46
Targeting metabolic pathways proteins of Orientia tsutsugamushi using combined hierarchical approach to combat scrub typhus. 38
30343521 2019
47
Profile of Pediatric Scrub Typhus in Odisha, India. 38
31064899 2019
48
Deforestation Increases the Risk of Scrub Typhus in Korea. 38
31035715 2019
49
Eschar in Scrub Typhus: A Study from North East India. 38
31309794 2019
50
Clinicoepidemiologic characteristics of scrub typhus and murine typhus: A multi-center study in southern Taiwan. 38
31088776 2019

Variations for Scrub Typhus

Expression for Scrub Typhus

Search GEO for disease gene expression data for Scrub Typhus.

Pathways for Scrub Typhus

Pathways related to Scrub Typhus according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.96 TNF TLR4 TLR2 IL10 IFNG
2
Show member pathways
12.57 TNF TLR4 TLR2 CD40LG
3
Show member pathways
12.5 TNF IL10 IFNG CD40LG
4
Show member pathways
12.48 TNF TLR4 TLR2 CD40LG
5
Show member pathways
12.43 TNF IL10 IFNG CD40LG
6
Show member pathways
12.41 TNF TLR4 TLR2 IL10 IFNG
7 12.35 TNF TLR2 IL10 IFNG CD40LG
8
Show member pathways
12.19 TNF TCN2 IFNG CRP
9
Show member pathways
12.13 TNF TLR4 TLR2
10
Show member pathways
12.08 TNF TLR2 F3
11
Show member pathways
12.07 TNF TLR4 IFNG
12 12.07 TNF TLR4 TLR2 IFNG
13
Show member pathways
12.05 TNF TLR4 TLR2 IFNG
14 12.02 TNF TLR4 TLR2 IL10 IFNG
15 11.9 TNF TLR4 IFNG
16 11.87 TNF IL10 IFNG
17
Show member pathways
11.86 TNF TLR4 TLR2 IFNG
18 11.81 TNF TLR4 CD40LG
19
Show member pathways
11.77 TNF TLR4 TLR2 IL10 IFNG
20
Show member pathways
11.71 TNF TLR4 TLR2 IL10 IFNG CD40LG
21 11.7 TNF IL10 IFNG
22 11.67 TNF TLR4 IL10
23 11.67 TNF TLR4 TLR2 IFNG
24
Show member pathways
11.66 TNF IFNG CD40LG
25 11.64 TNF IL10 IFNG
26 11.62 TNF IL10 IFNG
27 11.56 TNF TLR4 TLR2 IL10 IFNG
28
Show member pathways
11.55 TNF IFNG CD40LG
29 11.49 TNF TLR4 TLR2
30 11.3 TNF TLR4 TLR2 IFNG
31 11.25 TNF IL10 IFNG
32 11.24 TNF TLR4 IL10
33 11.13 TNF IL10 IFNG
34 11.08 TNF IL10 CD40LG
35 11.08 IL10 IFNG
36 11.06 TLR2 IFNG
37 10.93 TNF CRP
38 10.79 TNF TLR4 TLR2 IL10 IFNG CD40LG

GO Terms for Scrub Typhus

Cellular components related to Scrub Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TNF TCN2 IL10 IFNG F3 CRP
2 cell surface GO:0009986 9.35 TNF TLR4 TLR2 F3 CD40LG
3 extracellular space GO:0005615 9.23 TNF TCN2 IL10 IFNG GPT F3

Biological processes related to Scrub Typhus according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.91 TNF TLR4 TLR2 IFNG CRP
2 response to lipopolysaccharide GO:0032496 9.85 TLR4 TLR2 IL10
3 cellular response to lipopolysaccharide GO:0071222 9.85 TNF TLR4 IL10
4 defense response to Gram-positive bacterium GO:0050830 9.8 TNF TLR2 CRP
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.78 TNF TLR4 TLR2 CD40LG
6 positive regulation of inflammatory response GO:0050729 9.77 TNF TLR4 TLR2
7 positive regulation of interleukin-6 production GO:0032755 9.74 TNF TLR4 TLR2
8 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.73 TNF TLR4 TLR2
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.72 TNF TLR4 IFNG
10 negative regulation of interferon-gamma production GO:0032689 9.69 TLR4 IL10
11 regulation of synapse organization GO:0050807 9.69 TNF IL10
12 positive regulation of cytokine secretion GO:0050715 9.69 TNF IL10
13 positive regulation of interferon-beta production GO:0032728 9.68 TLR4 TLR2
14 positive regulation of protein complex assembly GO:0031334 9.68 TNF IFNG
15 positive regulation of osteoclast differentiation GO:0045672 9.67 TNF IFNG
16 microglial cell activation GO:0001774 9.67 TNF TLR2
17 positive regulation of macrophage activation GO:0043032 9.67 TLR4 IL10
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 TNF TLR4 TLR2
19 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.66 TNF IFNG
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.66 TNF IL10
21 negative regulation of growth of symbiont in host GO:0044130 9.65 TNF IL10
22 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.65 TLR4 TLR2
23 response to molecule of bacterial origin GO:0002237 9.64 TLR2 IL10
24 negative regulation of interleukin-17 production GO:0032700 9.64 TLR4 IFNG
25 I-kappaB phosphorylation GO:0007252 9.63 TLR4 TLR2
26 immune response GO:0006955 9.63 TNF TLR4 TLR2 IL10 IFNG CD40LG
27 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.62 TNF TLR4
28 cellular response to lipoteichoic acid GO:0071223 9.62 TLR4 TLR2
29 negative regulation of lipid storage GO:0010888 9.61 TNF CRP
30 endothelial cell apoptotic process GO:0072577 9.61 TNF IL10
31 positive regulation of MHC class II biosynthetic process GO:0045348 9.59 TLR4 IL10
32 negative regulation of cytokine secretion involved in immune response GO:0002740 9.58 TNF IL10
33 regulation of immunoglobulin secretion GO:0051023 9.58 TNF CD40LG
34 negative regulation of interleukin-6 production GO:0032715 9.58 TNF TLR4 IL10
35 receptor biosynthetic process GO:0032800 9.54 TNF IL10
36 positive regulation of interleukin-8 production GO:0032757 9.54 TNF TLR4 TLR2
37 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.52 TNF IFNG
38 positive regulation of interleukin-10 production GO:0032733 9.5 TLR4 TLR2 CD40LG
39 positive regulation of vitamin D biosynthetic process GO:0060557 9.46 TNF IFNG
40 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.43 TLR4 TLR2
41 positive regulation of chemokine production GO:0032722 9.43 TNF TLR4 TLR2
42 inflammatory response GO:0006954 9.43 TNF TLR4 TLR2 IL10 CRP CD40LG
43 regulation of cytokine secretion GO:0050707 9.35 TLR2
44 positive regulation of interleukin-12 production GO:0032735 8.92 TLR4 TLR2 IFNG CD40LG

Molecular functions related to Scrub Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide receptor activity GO:0001875 8.96 TLR4 TLR2
2 cytokine activity GO:0005125 8.92 TNF IL10 IFNG CD40LG

Sources for Scrub Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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