MCID: SCR008
MIFTS: 64

Scrub Typhus

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Scrub Typhus

MalaCards integrated aliases for Scrub Typhus:

Name: Scrub Typhus 12 60 56 45 15 17 74 3
Tsutsugamushi Disease 12 60
Tsutsugamushi Fever 12 60
Typhus Fever Due to Rickettsia Tsutsugamushi 12
Chigger-Borne Rickettsiosis 12
Mite-Borne Rickettsiosis 12
Scrub Mite-Borne Typhus 12
Chigger-Borne Typhus 12
Japanese River Fever 12
Mite-Borne Typhus 12
Tropical Typhus 12
Scrub Typhus 12
Tsutsugamushi 12
Kedani Fever 12

Characteristics:

Orphanet epidemiological data:

60
scrub typhus
Prevalence: 1-9/100000 (Korea, Republic of),1-9/1000000 (Japan); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 60  
Rare infectious diseases


Summaries for Scrub Typhus

CDC : 3 Typhus fevers are a group of diseases caused by bacteria that are spread to humans by fleas, lice, and chiggers. Typhus fevers include scrub typhus, murine typhus, and epidemic typhus. Chiggers spread scrub typhus, fleas spread murine typhus, and body lice spread epidemic typhus. The most common symptoms are fever, headaches, and sometimes rash.

MalaCards based summary : Scrub Typhus, also known as tsutsugamushi disease, is related to epidemic typhus and infantile liver failure syndrome 1. An important gene associated with Scrub Typhus is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and NF-KappaB Family Pathway. The drugs Doxycycline and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and skin, and related phenotypes are hyperhidrosis and fever

Disease Ontology : 12 A typhus that has material basis in Orientia tsutsugamushi, which is transmitted by trombiculid mites (Leptotrombidium deliense). The infection has symptom fever, has symptom headache, has symptom muscle pain, has symptom cough, has symptom maculopapular rash, has symptom eschar, has symptom splenomegaly and has symptom lymphadenopathy.

Wikipedia : 77 Scrub typhus or bush typhus is a form of typhus caused by the intracellular parasite Orientia... more...

Related Diseases for Scrub Typhus

Diseases related to Scrub Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 341)
# Related Disease Score Top Affiliating Genes
1 epidemic typhus 33.0 F3 GPT TCN2
2 infantile liver failure syndrome 1 31.2 GPT SLC17A5
3 transverse myelitis 31.0 IL10 TNF
4 hepatitis 30.9 GPT SLC17A5 TNF
5 poliomyelitis 30.6 IL10 TNF
6 hemorrhagic fever 30.5 GPT IL10 TNF
7 respiratory failure 30.4 CRP F3 TNF
8 hepatitis a 30.2 GPT IL10 TNF
9 liver cirrhosis 30.2 F3 GPT SLC17A5
10 leptospirosis 30.1 CRP IL10 IL1B TLR2 TNF
11 meningitis 30.1 CRP IL10 IL1B TLR2 TNF
12 aseptic meningitis 30.0 IL10 IL1B TNF
13 hellp syndrome 30.0 F3 GPT SLC17A5
14 viral hepatitis 30.0 GPT SLC17A5 TLR2 TNF
15 q fever 29.9 IL10 IL1B TLR2 TLR4 TNF
16 endocarditis 29.7 CRP IL10 TLR2 TNF
17 melioidosis 29.6 IL10 TLR2 TLR4 TNF
18 bacterial meningitis 29.6 CRP IL10 IL1B TLR2 TNF
19 pericarditis 29.6 CRP IL1B TNF
20 lyme disease 29.5 CRP IL1B TLR2 TNF
21 typhoid fever 29.4 CRP IL1B TLR4 TNF
22 peritonitis 29.2 CRP IL10 IL1B TLR2 TNF
23 pneumonia 29.2 CRP IL10 IL1B TLR2 TLR4 TNF
24 myocardial infarction 28.6 CRP F3 IL10 IL1B TLR4 TNF
25 malaria 28.0 CRP F3 IDO1 IL10 IL1B TCN2
26 acute respiratory distress syndrome 10.6
27 spotted fever 10.6
28 encephalitis 10.5
29 hemophagocytic lymphohistiocytosis 10.5
30 meningoencephalitis 10.5
31 fatty liver disease, nonalcoholic 1 10.5 GPT SLC17A5
32 kwashiorkor 10.5 GPT SLC17A5
33 pancreatitis 10.4
34 thrombocytopenia 10.4
35 multicentric castleman disease 10.4 CRP IL10
36 mesenteric lymphadenitis 10.4 CRP TLR2
37 compartment syndrome 10.4 SLC17A5 TNF
38 filarial elephantiasis 10.4 IL10 TLR2
39 dengue virus 10.4
40 cholecystitis 10.4
41 myocarditis 10.4
42 ischemic heart disease 10.4 CRP TNF
43 streptococcal meningitis 10.4 CRP TNF
44 relapsing fever 10.4 CRP TNF
45 louse-borne relapsing fever 10.4 CRP TNF
46 paraquat poisoning 10.4 GPT SLC17A5
47 hypersensitivity reaction type iii disease 10.4 CRP TNF
48 diverticulitis 10.4 CRP TNF
49 tuberculous peritonitis 10.4 CRP TNF
50 post-transplant lymphoproliferative disease 10.4 IL10 TNF

Graphical network of the top 20 diseases related to Scrub Typhus:



Diseases related to Scrub Typhus

Symptoms & Phenotypes for Scrub Typhus

Human phenotypes related to Scrub Typhus:

60 33 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperhidrosis 60 33 hallmark (90%) Very frequent (99-80%) HP:0000975
2 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
3 myalgia 60 33 hallmark (90%) Very frequent (99-80%) HP:0003326
4 skin rash 60 33 hallmark (90%) Very frequent (99-80%) HP:0000988
5 cough 60 33 hallmark (90%) Very frequent (99-80%) HP:0012735
6 lethargy 60 33 hallmark (90%) Very frequent (99-80%) HP:0001254
7 nausea and vomiting 60 33 frequent (33%) Frequent (79-30%) HP:0002017
8 hypotension 60 33 frequent (33%) Frequent (79-30%) HP:0002615
9 photophobia 60 33 frequent (33%) Frequent (79-30%) HP:0000613
10 abdominal pain 60 33 frequent (33%) Frequent (79-30%) HP:0002027
11 macule 60 33 frequent (33%) Frequent (79-30%) HP:0012733
12 headache 60 33 frequent (33%) Frequent (79-30%) HP:0002315
13 lymphadenopathy 60 33 frequent (33%) Frequent (79-30%) HP:0002716
14 gangrene 60 33 frequent (33%) Frequent (79-30%) HP:0100758
15 anterior uveitis 60 33 frequent (33%) Frequent (79-30%) HP:0012122
16 seizures 60 33 occasional (7.5%) Occasional (29-5%) HP:0001250
17 tremor 60 33 occasional (7.5%) Occasional (29-5%) HP:0001337
18 encephalitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0002383
19 splenomegaly 60 33 occasional (7.5%) Occasional (29-5%) HP:0001744
20 renal insufficiency 60 33 occasional (7.5%) Occasional (29-5%) HP:0000083
21 dyspnea 60 33 occasional (7.5%) Occasional (29-5%) HP:0002094
22 abnormal bleeding 60 33 occasional (7.5%) Occasional (29-5%) HP:0001892
23 myocarditis 60 33 occasional (7.5%) Occasional (29-5%) HP:0012819
24 meningitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0001287
25 restrictive ventilatory defect 60 33 occasional (7.5%) Occasional (29-5%) HP:0002091
26 behavioral abnormality 60 Occasional (29-5%)
27 reduced consciousness/confusion 60 Very frequent (99-80%)

MGI Mouse Phenotypes related to Scrub Typhus:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 CRP F3 IDO1 IL10 IL1B TLR2
2 homeostasis/metabolism MP:0005376 9.97 CRP F3 IDO1 IL10 IL1B SLC17A5
3 immune system MP:0005387 9.86 CRP F3 IDO1 IL10 IL1B TLR2
4 integument MP:0010771 9.63 F3 IL10 IL1B TLR2 TLR4 TNF
5 muscle MP:0005369 9.43 F3 IDO1 IL10 TLR2 TLR4 TNF
6 neoplasm MP:0002006 9.1 F3 IL10 IL1B TLR2 TLR4 TNF

Drugs & Therapeutics for Scrub Typhus

Drugs for Scrub Typhus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 564-25-0 54671203
2
Azithromycin Approved Phase 4 83905-01-5 55185 447043
3 Anti-Bacterial Agents Phase 4,Phase 3,Not Applicable
4 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
5 Antimalarials Phase 4,Phase 3,Not Applicable
6 Antiparasitic Agents Phase 4,Phase 3,Not Applicable
7 Antibiotics, Antitubercular Phase 4,Not Applicable
8 Antitubercular Agents Phase 4,Not Applicable
9 Antiprotozoal Agents Phase 4,Phase 3,Not Applicable
10
Telithromycin Approved Phase 3 191114-48-4 70789201 5462516
11
Rifampicin Approved Not Applicable 13292-46-1 5381226 5458213
12
carbamide peroxide Approved 124-43-6
13
Ethanol Approved 64-17-5 702
14 Nucleic Acid Synthesis Inhibitors Not Applicable
15 Cytochrome P-450 CYP3A Inducers Not Applicable
16 Vaccines
17 Immunoglobulins
18 Antibodies

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Scrub Typhus Antibiotic Resistance Trial Recruiting NCT03083197 Phase 4 Doxycycline 7 days;Doxycycline 3 days;Azithromycin 3 days
2 Controlled Trial: 5-day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00351182 Phase 3 Telithromycin;Doxycycline
3 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
4 Scrub Typhus Pediatric Immunology Study Completed NCT02398162
5 Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00568711 Not Applicable doxycycline;rifampin
6 Causes of Fever in Bangladeshi Patients Completed NCT02339259
7 Scrub Typhus Infection Induced Cardiovascular Disease Recruiting NCT03274869
8 Eschar Investigations in Scrub Typhus Recruiting NCT02915861
9 Scrub Typhus RDT Study Active, not recruiting NCT03269266
10 The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents Active, not recruiting NCT02876367
11 Rickettsiae in Myanmar Not yet recruiting NCT03847870

Search NIH Clinical Center for Scrub Typhus

Cochrane evidence based reviews: scrub typhus

Genetic Tests for Scrub Typhus

Anatomical Context for Scrub Typhus

MalaCards organs/tissues related to Scrub Typhus:

42
Testes, Kidney, Skin, T Cells, Brain, Monocytes, Eye

Publications for Scrub Typhus

Articles related to Scrub Typhus:

(show top 50) (show all 1178)
# Title Authors Year
1
Guillain-Barre syndrome: a rare complication of leptospirosis and scrub typhus co-infection. ( 30895887 )
2019
2
Clinical characteristics and effective treatments of scrub typhus-associated hemophagocytic lymphohistiocytosis in children. ( 30581619 )
2019
3
Recent Increase of Human Granulocytic Anaplasmosis and Co-Infection with Scrub Typhus or Korean Hemorrhagic Fever with Renal Syndrome in Korea. ( 30914905 )
2019
4
Case Report: Scrub Typhus and Q Fever Coinfection. ( 30915946 )
2019
5
Scrub typhus risk in travelers to southern Chile. ( 30639781 )
2019
6
Scrub typhus strikes back: Are we ready? ( 30705472 )
2019
7
The validity of diagnostic cut-offs for commercial and in-house scrub typhus IgM and IgG ELISAs: A review of the evidence. ( 30716070 )
2019
8
Epidemiology, Risk Factors and Seasonal Variation of Scrub Typhus Fever in Central Nepal. ( 30717408 )
2019
9
Scrub Typhus and Abnormal Electrocardiography. ( 30734694 )
2019
10
Severe fever with thrombocytopenia syndrome: comparison with scrub typhus and clinical diagnostic prediction. ( 30782137 )
2019
11
Dissemination of Orientia tsutsugamushi in a Case of Scrub Typhus. ( 30795827 )
2019
12
Hospitalisations and outpatient visits for undifferentiated fever attributable to scrub typhus in rural South India: Retrospective cohort and nested case-control study. ( 30802243 )
2019
13
Scrub Typhus in Continental Chile, 2016-20181. ( 30835200 )
2019
14
Determination of Optimal Diagnostic Cut-Offs for the Naval Medical Research Centre Scrub Typhus IgM ELISA in Chiang Rai, Thailand. ( 30860022 )
2019
15
Clinical Characteristics and Outcome of Children Hospitalized With Scrub Typhus in an Area of Endemicity. ( 30864670 )
2019
16
Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015-2017. ( 30882318 )
2019
17
Evaluation of Th1 and Th2 immune response in clinical and sub-clinical scrub typhus infection. ( 30904436 )
2019
18
Indicators of severe prognosis of scrub typhus: prognostic factors of scrub typhus severity. ( 30909868 )
2019
19
Geometric morphometrics of the scutum for differentiation of trombiculid mites within the genus Walchia (Acariformes: Prostigmata: Trombiculidae), a probable vector of scrub typhus. ( 30501981 )
2019
20
Kinetics of IgM and IgG antibodies after scrub typhus infection and the clinical implications. ( 29653201 )
2018
21
Scrub Typhus Outbreak in Chonburi Province, Central Thailand, 2013. ( 29350148 )
2018
22
Antinuclear antibodies in scrub typhus: Transient occurrence during acute illness. ( 29916449 )
2018
23
Scrub Typhus Meningitis Versus Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396931 )
2018
24
Scrub typhus initially manifested as diabetic ketoacidosis: A case report. ( 29872635 )
2018
25
Awareness and Work-Related Factors Associated with Scrub Typhus: A Case-Control Study from South Korea. ( 29865144 )
2018
26
Scrub typhus diagnosis on acute specimens using serological and molecular assays - a 3-year prospective study. ( 29706479 )
2018
27
Predictors of Mortality in Scrub Typhus Infection Requiring Intensive Care Admission in Tertiary Healthcare Centre of Nepal. ( 29971099 )
2018
28
Pulmonary Nocardiosis and Scrub Typhus in an Immunocompromised Host. ( 29910572 )
2018
29
Clinical profile and risk factors associated with severe scrub typhus infection among non-ICU patients in semi-urban south India. ( 29916448 )
2018
30
Diagnostic performance of serological tests to detect antibodies against acute scrub typhus infection in central India. ( 29735837 )
2018
31
Pseudothrombocytopenia and Usefulness of Platelet Aggregates in Peripheral Smear in the Diagnosis of Scrub Typhus. ( 29858982 )
2018
32
Comparison of Scrub Typhus Meningitis with Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396933 )
2018
33
Spectrum of cardiac manifestations and its relationship to outcomes in patients admitted with scrub typhus infection. ( 29430404 )
2018
34
Clinical proteomic analysis of scrub typhus infection. ( 29449793 )
2018
35
Meningitis due to scrub typhus: the importance of a differential diagnosis in an endemic area. ( 29654106 )
2018
36
Mixed Infection with Severe Fever with Thrombocytopenia Syndrome Virus and Two Genotypes of Scrub Typhus in a Patient, South Korea, 2017. ( 29943715 )
2018
37
Epididymo-Orchitis in Scrub Typhus. ( 29675739 )
2018
38
Scrub typhus re-emergence in India: Contributing factors and way forward. ( 29685200 )
2018
39
Complexity of type-specific 56 kDa antigen CD4 T-cell epitopes of Orientia tsutsugamushi strains causing scrub typhus in India. ( 29698425 )
2018
40
A Case Report and Literature Review of Scrub Typhus With Acute Abdomen and Septic Shock in a Child-The Role of Leukocytoclastic Vasculitis and Granulysin. ( 29697421 )
2018
41
Travel-acquired Scrub Typhus Infection Masked by Dengue Fever in a Patient from Nonendemic Area. ( 29910575 )
2018
42
Clinical Profile and Therapeutic Response of Scrub Typhus in Children: A Recent Trend from Eastern India. ( 29800384 )
2018
43
A Case of Scrub Typhus complicated with a Splenic Infarction. ( 29637756 )
2018
44
Scrub typhus reinfection. ( 29137528 )
2018
45
Predictors of Severity in Pediatric Scrub Typhus. ( 29368107 )
2018
46
Dysregulated Th1 Immune and Vascular Responses in Scrub Typhus Pathogenesis. ( 29431689 )
2018
47
Dissemination of <i>Orientia tsutsugamushi</i>, a Causative Agent of Scrub Typhus, and Immunological Responses in the Humanized DRAGA Mouse. ( 29760694 )
2018
48
Scrub typhus: Atypical presentation in subhimalayan region. ( 29692489 )
2018
49
Acute transverse myelitis following scrub typhus: A case report and review of the literature. ( 29350608 )
2018
50
Scrub typhus and depression: a nationwide cohort analysis. ( 30509305 )
2018

Variations for Scrub Typhus

Expression for Scrub Typhus

Search GEO for disease gene expression data for Scrub Typhus.

Pathways for Scrub Typhus

Pathways related to Scrub Typhus according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 IL10 IL1B TLR2 TLR4 TNF
2
Show member pathways
12.56 IL1B TLR2 TLR4 TNF
3
Show member pathways
12.48 IL1B TLR2 TLR4 TNF
4
Show member pathways
12.47 IL10 IL1B TLR2 TLR4 TNF
5
Show member pathways
12.44 IL1B TLR2 TLR4 TNF
6 12.42 IDO1 IL10 IL1B TLR2 TNF
7
Show member pathways
12.22 CRP IL1B TCN2 TNF
8 12.17 TLR2 TLR4 TNF
9
Show member pathways
12.14 TLR2 TLR4 TNF
10
Show member pathways
12.13 IL10 IL1B TLR2 TLR4 TNF
11
Show member pathways
12.11 F3 IL1B TLR2 TNF
12
Show member pathways
12.09 IL10 IL1B TNF
13
Show member pathways
12.09 IL1B TLR4 TNF
14
Show member pathways
12.08 IL1B TLR2 TLR4 TNF
15 12.08 IL10 IL1B TLR2 TLR4 TNF
16 12.06 TLR2 TLR4 TNF
17 12.05 IL10 IL1B TNF
18
Show member pathways
11.93 IL1B TLR2 TLR4 TNF
19
Show member pathways
11.91 IL1B TLR2 TLR4
20 11.89 IL1B TLR4 TNF
21 11.86 IL10 IL1B TNF
22
Show member pathways
11.83 IL10 IL1B TLR2 TLR4 TNF
23 11.8 F3 IL1B TNF
24 11.77 IL1B TLR4 TNF
25 11.75 IL1B TLR2 TLR4 TNF
26 11.68 IL10 IL1B TNF
27 11.66 IL10 IL1B TLR4 TNF
28 11.64 IL10 IL1B TNF
29 11.62 IL10 IL1B TNF
30 11.45 IL1B TLR2 TLR4 TNF
31 11.44 IL10 IL1B TNF
32 11.35 IL1B TLR2 TLR4 TNF
33 11.34 IL10 IL1B TLR2 TLR4 TNF
34 11.19 IL10 IL1B TNF
35 11.13 IDO1 IL10 IL1B TNF
36 11.09 IL10 IL1B TNF
37 11.08 IL1B TLR2
38 11 IL1B TNF
39 11 IL10 IL1B TLR4 TNF
40 10.93 CRP TNF
41 10.85 IL1B TNF
42 10.71 IL10 IL1B TLR2 TLR4 TNF

GO Terms for Scrub Typhus

Cellular components related to Scrub Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CRP F3 GPT IL10 IL1B TCN2

Biological processes related to Scrub Typhus according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.98 IL10 IL1B TLR2 TLR4 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.94 F3 IL10 IL1B TNF
3 positive regulation of gene expression GO:0010628 9.92 CRP IL1B TLR2 TLR4 TNF
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.89 IL1B TLR4 TNF
5 activation of MAPK activity GO:0000187 9.86 IL1B TLR4 TNF
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.85 IL10 IL1B TNF
7 defense response to Gram-positive bacterium GO:0050830 9.85 CRP TLR2 TNF
8 cellular response to lipopolysaccharide GO:0071222 9.84 IL10 IL1B TLR4 TNF
9 positive regulation of JNK cascade GO:0046330 9.83 IL1B TLR4 TNF
10 positive regulation of inflammatory response GO:0050729 9.81 TLR2 TLR4 TNF
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 IL1B TLR2 TLR4 TNF
12 positive regulation of interferon-gamma production GO:0032729 9.75 IL1B TLR4 TNF
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.74 IL1B TLR4 TNF
14 negative regulation of interferon-gamma production GO:0032689 9.72 IL10 TLR4
15 positive regulation of cytokine secretion GO:0050715 9.72 IL10 TNF
16 regulation of synapse organization GO:0050807 9.72 IL10 TNF
17 positive regulation of interferon-beta production GO:0032728 9.71 TLR2 TLR4
18 negative regulation of neurogenesis GO:0050768 9.71 IL1B TNF
19 positive regulation of interleukin-10 production GO:0032733 9.71 TLR2 TLR4
20 microglial cell activation GO:0001774 9.71 TLR2 TNF
21 negative regulation of lipid catabolic process GO:0050995 9.7 IL1B TNF
22 positive regulation of glial cell proliferation GO:0060252 9.7 IL1B TNF
23 positive regulation of macrophage activation GO:0043032 9.7 IL10 TLR4
24 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.7 IL1B TNF
25 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 IL1B TNF
26 negative regulation of growth of symbiont in host GO:0044130 9.69 IL10 TNF
27 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.68 TLR2 TLR4
28 regulation of cytokine secretion GO:0050707 9.68 TLR2 TLR4
29 I-kappaB phosphorylation GO:0007252 9.68 TLR2 TLR4
30 response to molecule of bacterial origin GO:0002237 9.67 IL10 TLR2
31 cellular response to lipoteichoic acid GO:0071223 9.67 TLR2 TLR4
32 positive regulation of interleukin-6 production GO:0032755 9.67 IL1B TLR2 TLR4 TNF
33 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.66 TLR4 TNF
34 negative regulation of lipid storage GO:0010888 9.66 CRP TNF
35 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
36 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B TNF
37 negative regulation of interleukin-6 production GO:0032715 9.65 IL10 TLR4 TNF
38 response to lipopolysaccharide GO:0032496 9.65 IDO1 IL10 IL1B TLR2 TLR4
39 positive regulation of MHC class II biosynthetic process GO:0045348 9.63 IL10 TLR4
40 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
41 positive regulation of interleukin-12 production GO:0032735 9.63 IDO1 TLR2 TLR4
42 negative regulation of cytokine secretion involved in immune response GO:0002740 9.62 IL10 TNF
43 positive regulation of neuroinflammatory response GO:0150078 9.62 IL1B TNF
44 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.62 IL1B TLR2 TLR4 TNF
45 response to glucocorticoid GO:0051384 9.61 IL10 TNF
46 positive regulation of fever generation GO:0031622 9.61 IL1B TNF
47 positive regulation of chemokine production GO:0032722 9.61 TLR2 TLR4 TNF
48 sequestering of triglyceride GO:0030730 9.59 IL1B TNF
49 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL10 IL1B TNF
50 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.56 IL1B TNF

Molecular functions related to Scrub Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Scrub Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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