MCID: SCR008
MIFTS: 64

Scrub Typhus

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Scrub Typhus

MalaCards integrated aliases for Scrub Typhus:

Name: Scrub Typhus 12 59 55 3 44 15 73
Tsutsugamushi Disease 12 59
Tsutsugamushi Fever 12 59
Typhus Fever Due to Rickettsia Tsutsugamushi 12
Chigger-Borne Rickettsiosis 12
Mite-Borne Rickettsiosis 12
Scrub Mite-Borne Typhus 12
Chigger-Borne Typhus 12
Japanese River Fever 12
Mite-Borne Typhus 12
Tropical Typhus 12
Scrub Typhus 12
Tsutsugamushi 12
Kedani Fever 12

Characteristics:

Orphanet epidemiological data:

59
scrub typhus
Prevalence: 1-9/100000 (Korea, Republic of),1-9/1000000 (Japan); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


Summaries for Scrub Typhus

CDC : 3 Typhus fevers are a group of diseases caused by bacteria that are spread to humans by fleas, lice, and chiggers. Typhus fevers include scrub typhus, murine typhus, and epidemic typhus. Chiggers spread scrub typhus, fleas spread murine typhus, and body lice spread epidemic typhus. The most common symptoms are fever, headaches, and sometimes rash.

MalaCards based summary : Scrub Typhus, also known as tsutsugamushi disease, is related to epidemic typhus and infantile liver failure syndrome 1. An important gene associated with Scrub Typhus is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Influenza A. The drugs Doxycycline and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and kidney, and related phenotypes are hyperhidrosis and seizures

Disease Ontology : 12 A typhus that has material basis in Orientia tsutsugamushi, which is transmitted by trombiculid mites (Leptotrombidium deliense). The infection has symptom fever, has symptom headache, has symptom muscle pain, has symptom cough, has symptom maculopapular rash, has symptom eschar, has symptom splenomegaly and has symptom lymphadenopathy.

Wikipedia : 76 Scrub typhus or bush typhus is a form of typhus caused by the intracellular parasite Orientia... more...

Related Diseases for Scrub Typhus

Diseases related to Scrub Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 344)
# Related Disease Score Top Affiliating Genes
1 epidemic typhus 33.0 F3 GPT TCN2
2 infantile liver failure syndrome 1 30.9 GPT SLC17A5
3 transverse myelitis 30.8 IL10 TNF
4 hepatitis 30.7 GPT SLC17A5 TNF
5 respiratory failure 30.4 CRP F3 TNF
6 leptospirosis 30.4 CRP IL10 IL1B TLR2 TNF
7 meningitis 30.4 CRP IL10 IL1B TLR2 TNF
8 q fever 30.2 IL10 IL1B TLR2 TLR4 TNF
9 hepatitis a 30.2 GPT IL10 TNF
10 liver cirrhosis 30.1 F3 GPT SLC17A5
11 aseptic meningitis 30.1 IL10 IL1B TNF
12 hellp syndrome 30.0 F3 GPT SLC17A5
13 viral hepatitis 30.0 GPT SLC17A5 TLR2 TNF
14 bacterial meningitis 29.9 CRP IL10 IL1B TLR2 TNF
15 hemorrhagic fever 29.9 F3 GPT IL10 TNF
16 endocarditis 29.7 CRP IL10 TLR2 TNF
17 viral infectious disease 29.7 GPT IL10 IL1B TNF
18 lyme disease 29.7 CRP IL1B TLR2 TNF
19 melioidosis 29.7 IL10 TLR2 TLR4 TNF
20 typhoid fever 29.7 CRP IL1B TLR4 TNF
21 pericarditis 29.6 CRP IL1B TNF
22 pneumonia 29.6 CRP IL10 IL1B TLR2 TLR4 TNF
23 peritonitis 29.5 CRP IL10 IL1B TLR2 TNF
24 myocardial infarction 29.1 CRP F3 IL10 IL1B TLR4 TNF
25 malaria 29.0 CRP F3 IDO1 IL10 IL1B TCN2
26 acute respiratory distress syndrome 10.6
27 spotted fever 10.6
28 encephalitis 10.5
29 hemophagocytic lymphohistiocytosis 10.5
30 meningoencephalitis 10.5
31 pancreatitis 10.4
32 dengue virus 10.4
33 thrombocytopenia 10.4
34 cholecystitis 10.4
35 myocarditis 10.4
36 acute liver failure 10.3
37 japanese spotted fever 10.3
38 disseminated intravascular coagulation 10.3
39 neuritis 10.3
40 myelitis 10.3
41 fatty liver disease, nonalcoholic 1 10.3 GPT SLC17A5
42 kwashiorkor 10.3 GPT SLC17A5
43 mesenteric lymphadenitis 10.3 CRP TLR2
44 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
45 dengue disease 10.3
46 optic neuritis 10.3
47 orchitis 10.3
48 acute pancreatitis 10.3
49 vasculitis 10.3
50 epididymo-orchitis 10.3

Graphical network of the top 20 diseases related to Scrub Typhus:



Diseases related to Scrub Typhus

Symptoms & Phenotypes for Scrub Typhus

Human phenotypes related to Scrub Typhus:

59 32 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperhidrosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0000975
2 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
3 tremor 59 32 occasional (7.5%) Occasional (29-5%) HP:0001337
4 nausea and vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002017
5 encephalitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002383
6 hypotension 59 32 frequent (33%) Frequent (79-30%) HP:0002615
7 splenomegaly 59 32 occasional (7.5%) Occasional (29-5%) HP:0001744
8 renal insufficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0000083
9 photophobia 59 32 frequent (33%) Frequent (79-30%) HP:0000613
10 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
11 dyspnea 59 32 occasional (7.5%) Occasional (29-5%) HP:0002094
12 abnormal bleeding 59 32 occasional (7.5%) Occasional (29-5%) HP:0001892
13 abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002027
14 myalgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0003326
15 macule 59 32 frequent (33%) Frequent (79-30%) HP:0012733
16 myocarditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0012819
17 skin rash 59 32 hallmark (90%) Very frequent (99-80%) HP:0000988
18 meningitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001287
19 cough 59 32 hallmark (90%) Very frequent (99-80%) HP:0012735
20 lethargy 59 32 hallmark (90%) Very frequent (99-80%) HP:0001254
21 headache 59 32 frequent (33%) Frequent (79-30%) HP:0002315
22 lymphadenopathy 59 32 frequent (33%) Frequent (79-30%) HP:0002716
23 gangrene 59 32 frequent (33%) Frequent (79-30%) HP:0100758
24 restrictive ventilatory defect 59 32 occasional (7.5%) Occasional (29-5%) HP:0002091
25 anterior uveitis 59 32 frequent (33%) Frequent (79-30%) HP:0012122
26 behavioral abnormality 59 Occasional (29-5%)
27 reduced consciousness/confusion 59 Very frequent (99-80%)

MGI Mouse Phenotypes related to Scrub Typhus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 CRP F3 IDO1 IL10 IL1B TLR2
2 homeostasis/metabolism MP:0005376 9.97 CRP F3 IDO1 IL10 IL1B SLC17A5
3 immune system MP:0005387 9.86 CRP F3 IDO1 IL10 IL1B TLR2
4 integument MP:0010771 9.63 F3 IL10 IL1B TLR2 TLR4 TNF
5 muscle MP:0005369 9.43 F3 IDO1 IL10 TLR2 TLR4 TNF
6 neoplasm MP:0002006 9.1 F3 IL10 IL1B TLR2 TLR4 TNF

Drugs & Therapeutics for Scrub Typhus

Drugs for Scrub Typhus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 564-25-0 54671203
2
Azithromycin Approved Phase 4 83905-01-5 55185 447043
3 Antibiotics, Antitubercular Phase 4,Not Applicable
4 Antimalarials Phase 4,Phase 3,Not Applicable
5 Antitubercular Agents Phase 4,Not Applicable
6 Anti-Bacterial Agents Phase 4,Phase 3,Not Applicable
7 Antiparasitic Agents Phase 4,Phase 3,Not Applicable
8 Antiprotozoal Agents Phase 4,Phase 3,Not Applicable
9 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
10
Telithromycin Approved Phase 3 191114-48-4 0 5462516
11
Rifampicin Approved Not Applicable 13292-46-1 5458213 5381226
12
Ethanol Approved 64-17-5 702
13 Nucleic Acid Synthesis Inhibitors Not Applicable
14 Cytochrome P-450 CYP3A Inducers Not Applicable
15 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Scrub Typhus Antibiotic Resistance Trial Recruiting NCT03083197 Phase 4 Doxycycline 7 days;Doxycycline 3 days;Azithromycin 3 days
2 Controlled Trial: 5-Day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00351182 Phase 3 Telithromycin;Doxycycline
3 Controlled Trial: 5-Day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00568711 Not Applicable doxycycline;rifampin
4 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
5 Scrub Typhus Pediatric Immunology Study Completed NCT02398162
6 Causes of Fever in Bangladeshi Patients Completed NCT02339259
7 Scrub Typhus Infection Induced Cardiovascular Disease Recruiting NCT03274869
8 Eschar Investigations in Scrub Typhus Recruiting NCT02915861
9 Scrub Typhus RDT Study Active, not recruiting NCT03269266
10 The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents Active, not recruiting NCT02876367

Search NIH Clinical Center for Scrub Typhus

Cochrane evidence based reviews: scrub typhus

Genetic Tests for Scrub Typhus

Anatomical Context for Scrub Typhus

MalaCards organs/tissues related to Scrub Typhus:

41
Testes, Liver, Kidney, Monocytes, Lung, Heart, Thyroid

Publications for Scrub Typhus

Articles related to Scrub Typhus:

(show top 50) (show all 1099)
# Title Authors Year
1
Kinetics of IgM and IgG antibodies after scrub typhus infection and the clinical implications. ( 29653201 )
2018
2
Scrub Typhus Outbreak in Chonburi Province, Central Thailand, 2013. ( 29350148 )
2018
3
Antinuclear antibodies in scrub typhus: Transient occurrence during acute illness. ( 29916449 )
2018
4
Scrub Typhus Meningitis Versus Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396931 )
2018
5
Scrub typhus initially manifested as diabetic ketoacidosis: A case report. ( 29872635 )
2018
6
Awareness and Work-Related Factors Associated with Scrub Typhus: A Case-Control Study from South Korea. ( 29865144 )
2018
7
Scrub typhus diagnosis on acute specimens using serological and molecular assays - a 3-year prospective study. ( 29706479 )
2018
8
Predictors of Mortality in Scrub Typhus Infection Requiring Intensive Care Admission in Tertiary Healthcare Centre of Nepal. ( 29971099 )
2018
9
Pulmonary Nocardiosis and Scrub Typhus in an Immunocompromised Host. ( 29910572 )
2018
10
Clinical profile and risk factors associated with severe scrub typhus infection among non-ICU patients in semi-urban south India. ( 29916448 )
2018
11
Diagnostic performance of serological tests to detect antibodies against acute scrub typhus infection in central India. ( 29735837 )
2018
12
Pseudothrombocytopenia and Usefulness of Platelet Aggregates in Peripheral Smear in the Diagnosis of Scrub Typhus. ( 29858982 )
2018
13
Comparison of Scrub Typhus Meningitis with Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396933 )
2018
14
Spectrum of cardiac manifestations and its relationship to outcomes in patients admitted with scrub typhus infection. ( 29430404 )
2018
15
Clinical proteomic analysis of scrub typhus infection. ( 29449793 )
2018
16
Meningitis due to scrub typhus: the importance of a differential diagnosis in an endemic area. ( 29654106 )
2018
17
Mixed Infection with Severe Fever with Thrombocytopenia Syndrome Virus and Two Genotypes of Scrub Typhus in a Patient, South Korea, 2017. ( 29943715 )
2018
18
Epididymo-Orchitis in Scrub Typhus. ( 29675739 )
2018
19
Scrub typhus re-emergence in India: Contributing factors and way forward. ( 29685200 )
2018
20
Complexity of type-specific 56 kDa antigen CD4 T-cell epitopes of Orientia tsutsugamushi strains causing scrub typhus in India. ( 29698425 )
2018
21
A Case Report and Literature Review of Scrub Typhus With Acute Abdomen and Septic Shock in a Child-The Role of Leukocytoclastic Vasculitis and Granulysin. ( 29697421 )
2018
22
Travel-acquired Scrub Typhus Infection Masked by Dengue Fever in a Patient from Nonendemic Area. ( 29910575 )
2018
23
Clinical Profile and Therapeutic Response of Scrub Typhus in Children: A Recent Trend from Eastern India. ( 29800384 )
2018
24
A Case of Scrub Typhus complicated with a Splenic Infarction. ( 29637756 )
2018
25
Scrub typhus reinfection. ( 29137528 )
2018
26
Predictors of Severity in Pediatric Scrub Typhus. ( 29368107 )
2018
27
Dysregulated Th1 Immune and Vascular Responses in Scrub Typhus Pathogenesis. ( 29431689 )
2018
28
Dissemination of <i>Orientia tsutsugamushi</i>, a Causative Agent of Scrub Typhus, and Immunological Responses in the Humanized DRAGA Mouse. ( 29760694 )
2018
29
Acute transverse myelitis following scrub typhus: A case report and review of the literature. ( 29350608 )
2018
30
Scrub typhus and depression: a nationwide cohort analysis. ( 30509305 )
2018
31
Occurrence of Orientia tsutsugamushi, the Etiological Agent of Scrub Typhus in Animal Hosts and Mite Vectors in Areas Reporting Human Cases of Acute Encephalitis Syndrome in the Gorakhpur Region of Uttar Pradesh, India. ( 30016222 )
2018
32
Acute encephalopathy with biphasic seizures and late diffusion restriction in scrub typhus encephalitis. ( 30039462 )
2018
33
Mild encephalitis/encephalopathy with reversible splenial lesion complicated with scrub typhus. ( 30054749 )
2018
34
Hemophagocytic Lymphohistiocytosis Associated with Scrub Typhus: Systematic Review and Comparison between Pediatric and Adult Cases. ( 30274417 )
2018
35
Hemophagocytic lymphohistiocytosis with neurological manifestations in an infant with scrub typhus: a rare fatal occurrence. ( 30360694 )
2018
36
Distinguishing Japanese Spotted Fever and Scrub Typhus, Central Japan, 2004- 2015. ( 30124190 )
2018
37
Case Report: Concurrent Sympatric Scrub Typhus and Japanese Spotted Fever in Japan. ( 30298801 )
2018
38
Surveillance for Scrub Typhus, Rickettsial Diseases, and Leptospirosis in US and Multinational Military Training Exercise Cobra Gold Sites in Thailand. ( 30165719 )
2018
39
A case report of scrub typhus complicated with myocarditis and rhabdomyolysis. ( 30404620 )
2018
40
Anti-aquaporin-4 Antibody Positive Optic Neuritis Following Scrub Typhus in an Elderly Female. ( 30379739 )
2018
41
Differentiation of Severe Fever With Thrombocytopenia Syndrome From Scrub Typhus. ( 29293899 )
2018
42
Effects of Rifampin and Doxycycline Treatments in Patients With Uncomplicated Scrub Typhus: An Open-Label, Randomized, Controlled Trial. ( 29462266 )
2018
43
Autofluorescence microscopy for paired-matched morphological and molecular identification of individual chigger mites (Acari: Trombiculidae), the vectors of scrub typhus. ( 29494599 )
2018
44
Characterization of the rhesus macaque (Macaca mulatta) scrub typhus model: Susceptibility to intradermal challenge with the human pathogen Orientia tsutsugamushi Karp. ( 29522521 )
2018
45
Scrub Typhus - A Major Cause of Pediatric Intensive Care Admission and Multiple Organ Dysfunction Syndrome: A Single-Center Experience from India. ( 29531452 )
2018
46
Mathematical Modeling for Scrub Typhus and Its Implications for Disease Control. ( 29542303 )
2018
47
Central nervous system lesions in scrub typhus rediscovered: An autopsy report. ( 29547167 )
2018
48
Prevalence of scrub typhus in pyrexia of unknown origin and assessment of interleukin-8, tumor necrosis factor-alpha, and interferon-gamma levels in scrub typhus-positive patients. ( 29567888 )
2018
49
Scrub typhus point-of-care testing: A systematic review and meta-analysis. ( 29579046 )
2018
50
Clinical profile and outcome of children with scrub typhus from Chennai, South India. ( 29637374 )
2018

Variations for Scrub Typhus

Expression for Scrub Typhus

Search GEO for disease gene expression data for Scrub Typhus.

Pathways for Scrub Typhus

Pathways related to Scrub Typhus according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.86 IL10 IL1B TLR2 TLR4 TNF
2
Show member pathways
12.65 IL1B TLR2 TLR4 TNF
3
Show member pathways
12.56 IL1B TLR2 TLR4 TNF
4
Show member pathways
12.48 IL1B TLR2 TLR4 TNF
5
Show member pathways
12.47 IL10 IL1B TLR2 TLR4 TNF
6 12.42 IDO1 IL10 IL1B TLR2 TNF
7
Show member pathways
12.22 CRP IL1B TCN2 TNF
8 12.17 TLR2 TLR4 TNF
9
Show member pathways
12.14 TLR2 TLR4 TNF
10
Show member pathways
12.13 IL10 IL1B TLR2 TLR4 TNF
11
Show member pathways
12.11 F3 IL1B TLR2 TNF
12
Show member pathways
12.09 IL10 IL1B TNF
13
Show member pathways
12.09 IL1B TLR4 TNF
14
Show member pathways
12.08 IL1B TLR2 TLR4 TNF
15 12.08 IL10 IL1B TLR2 TLR4 TNF
16 12.06 TLR2 TLR4 TNF
17 12.05 IL10 IL1B TNF
18
Show member pathways
11.93 IL1B TLR2 TLR4 TNF
19
Show member pathways
11.91 IL1B TLR2 TLR4
20 11.89 IL1B TLR4 TNF
21 11.86 IL10 IL1B TNF
22
Show member pathways
11.83 IL10 IL1B TLR2 TLR4 TNF
23 11.79 F3 IL1B TNF
24 11.77 IL1B TLR4 TNF
25 11.75 IL1B TLR2 TLR4 TNF
26 11.68 IL10 IL1B TNF
27 11.66 IL10 IL1B TLR4 TNF
28 11.64 IL10 IL1B TNF
29 11.62 IL10 IL1B TNF
30 11.45 IL1B TLR2 TLR4 TNF
31 11.44 IL10 IL1B TNF
32 11.35 IL1B TLR2 TLR4 TNF
33 11.34 IL10 IL1B TLR2 TLR4 TNF
34 11.19 IL10 IL1B TNF
35 11.1 IDO1 IL10 IL1B TNF
36 11.09 IL10 IL1B TNF
37 11.08 IL1B TLR2
38 11 IL1B TNF
39 11 IL10 IL1B TLR4 TNF
40 10.93 CRP TNF
41 10.85 IL1B TNF
42 10.71 IL10 IL1B TLR2 TLR4 TNF

GO Terms for Scrub Typhus

Cellular components related to Scrub Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CRP F3 GPT IL10 IL1B TCN2

Biological processes related to Scrub Typhus according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.98 IL10 IL1B TLR2 TLR4 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.94 F3 IL10 IL1B TNF
3 positive regulation of gene expression GO:0010628 9.92 CRP IL1B TLR2 TLR4 TNF
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.89 IL1B TLR4 TNF
5 activation of MAPK activity GO:0000187 9.86 IL1B TLR4 TNF
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.85 IL10 IL1B TNF
7 defense response to Gram-positive bacterium GO:0050830 9.85 CRP TLR2 TNF
8 cellular response to lipopolysaccharide GO:0071222 9.84 IL10 IL1B TLR4 TNF
9 positive regulation of JNK cascade GO:0046330 9.83 IL1B TLR4 TNF
10 positive regulation of inflammatory response GO:0050729 9.81 TLR2 TLR4 TNF
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 IL1B TLR2 TLR4 TNF
12 response to glucocorticoid GO:0051384 9.79 IL10 IL1B TNF
13 positive regulation of interferon-gamma production GO:0032729 9.75 IL1B TLR4 TNF
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.74 IL1B TLR4 TNF
15 negative regulation of interferon-gamma production GO:0032689 9.72 IL10 TLR4
16 positive regulation of cytokine secretion GO:0050715 9.72 IL10 TNF
17 regulation of synapse organization GO:0050807 9.72 IL10 TNF
18 positive regulation of interferon-beta production GO:0032728 9.71 TLR2 TLR4
19 negative regulation of neurogenesis GO:0050768 9.71 IL1B TNF
20 positive regulation of interleukin-10 production GO:0032733 9.71 TLR2 TLR4
21 microglial cell activation GO:0001774 9.71 TLR2 TNF
22 negative regulation of lipid catabolic process GO:0050995 9.7 IL1B TNF
23 positive regulation of glial cell proliferation GO:0060252 9.7 IL1B TNF
24 positive regulation of macrophage activation GO:0043032 9.7 IL10 TLR4
25 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.7 IL1B TNF
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 IL1B TNF
27 negative regulation of growth of symbiont in host GO:0044130 9.69 IL10 TNF
28 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.68 TLR2 TLR4
29 regulation of cytokine secretion GO:0050707 9.68 TLR2 TLR4
30 I-kappaB phosphorylation GO:0007252 9.68 TLR2 TLR4
31 response to molecule of bacterial origin GO:0002237 9.67 IL10 TLR2
32 cellular response to lipoteichoic acid GO:0071223 9.67 TLR2 TLR4
33 positive regulation of interleukin-6 production GO:0032755 9.67 IL1B TLR2 TLR4 TNF
34 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.66 TLR4 TNF
35 negative regulation of lipid storage GO:0010888 9.66 CRP TNF
36 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
37 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B TNF
38 negative regulation of interleukin-6 production GO:0032715 9.65 IL10 TLR4 TNF
39 response to lipopolysaccharide GO:0032496 9.65 IDO1 IL10 IL1B TLR2 TLR4
40 positive regulation of MHC class II biosynthetic process GO:0045348 9.63 IL10 TLR4
41 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
42 positive regulation of interleukin-12 production GO:0032735 9.63 IDO1 TLR2 TLR4
43 negative regulation of cytokine secretion involved in immune response GO:0002740 9.62 IL10 TNF
44 positive regulation of neuroinflammatory response GO:0150078 9.62 IL1B TNF
45 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.62 IL1B TLR2 TLR4 TNF
46 positive regulation of fever generation GO:0031622 9.61 IL1B TNF
47 positive regulation of chemokine production GO:0032722 9.61 TLR2 TLR4 TNF
48 chronic inflammatory response to antigenic stimulus GO:0002439 9.6 IL1B TNF
49 sequestering of triglyceride GO:0030730 9.59 IL1B TNF
50 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL10 IL1B TNF

Molecular functions related to Scrub Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Scrub Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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