MCID: SCR008
MIFTS: 58

Scrub Typhus

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Scrub Typhus

MalaCards integrated aliases for Scrub Typhus:

Name: Scrub Typhus 12 58 54 43 15 17 71
Typhus Fever Due to Rickettsia Tsutsugamushi 12 32
Tsutsugamushi Disease 12 58
Tsutsugamushi Fever 12 58
Chigger-Borne Rickettsiosis 12
Mite-Borne Rickettsiosis 12
Scrub Mite-Borne Typhus 12
Chigger-Borne Typhus 12
Japanese River Fever 12
Mite-Borne Typhus 12
Tropical Typhus 12
Scrub Typhus 12
Tsutsugamushi 12
Kedani Fever 12

Characteristics:

Orphanet epidemiological data:

58
scrub typhus
Prevalence: 1-9/100000 (Korea, Republic of),1-9/1000000 (Japan); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Scrub Typhus

Disease Ontology : 12 A typhus that has material basis in Orientia tsutsugamushi, which is transmitted by trombiculid mites (Leptotrombidium deliense). The infection has symptom fever, has symptom headache, has symptom muscle pain, has symptom cough, has symptom maculopapular rash, has symptom eschar, has symptom splenomegaly and has symptom lymphadenopathy.

MalaCards based summary : Scrub Typhus, also known as typhus fever due to rickettsia tsutsugamushi, is related to epidemic typhus and transverse myelitis. An important gene associated with Scrub Typhus is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Doxycycline and Antibiotics, Antitubercular have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and liver, and related phenotypes are hyperhidrosis and fever

Wikipedia : 74 Scrub typhus or bush typhus is a form of typhus caused by the intracellular parasite Orientia... more...

Related Diseases for Scrub Typhus

Diseases related to Scrub Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 731)
# Related Disease Score Top Affiliating Genes
1 epidemic typhus 31.7 TLR4 TLR2 TCN2 GPT CRP CD40LG
2 transverse myelitis 31.2 TNF IL17A IL10
3 disseminated intravascular coagulation 31.2 TNF IL10 GPT F3 CRP
4 hemophagocytic lymphohistiocytosis 30.8 TNF IL18 IL10 IFNG GPT
5 exanthem 30.8 TNF IL10 GPT F3 CRP CD40LG
6 meningoencephalitis 30.8 TNF SLC17A5 IL10 CRP CD40LG
7 analbuminemia 30.8 SLC17A5 GPT F3 CRP
8 dengue disease 30.8 TNF GPT CD40LG
9 acute kidney failure 30.7 LCN2 IL18 HAVCR1 GPT
10 respiratory failure 30.7 TNF IL1B IL10 GPT F3 CRP
11 pulmonary edema 30.6 TNF IL1B IL10 CRP
12 radiculopathy 30.6 IL17A IL15 IL10
13 optic neuritis 30.6 TNF IL1B IL10
14 adult respiratory distress syndrome 30.5 TNF IL1B IL10
15 liver cirrhosis 30.5 TLR2 SLC17A5 GPT F3
16 acalculous cholecystitis 30.5 GPT CRP CD40LG
17 plague 30.5 TNF TLR4 TLR2 IL10
18 neuritis 30.4 TNF IL1B IL10 IFNG
19 conjunctivitis 30.4 TNF IL10 IFNG
20 haemophilus influenzae 30.4 TNF TLR2
21 lymphopenia 30.4 IL18 IL15 IL10 IFNG
22 myelitis 30.4 TNF IL17A IL10 CD40LG
23 hantavirus hemorrhagic fever with renal syndrome 30.3 TNF F3 CRP CD40LG
24 splenic infarction 30.3 GPT F3 CRP CD40LG
25 hepatitis 30.3 TNF SLC17A5 IFNG HAVCR1 GPT
26 duodenal ulcer 30.3 TNF TLR4 IL1B IL10
27 acute pyelonephritis 30.3 LCN2 IL10 GPT CRP
28 bilirubin metabolic disorder 30.2 SLC17A5 GPT F3 CRP CD40LG
29 peptic ulcer disease 30.2 TNF IL1B IL10
30 japanese spotted fever 30.2 CRP CD40LG AFF2
31 common cold 30.2 TNF TLR4 TLR2 IL17A IL10
32 chikungunya 30.2 TNF IL1B IL18
33 astrakhan spotted fever 30.2 F3 CD40LG
34 orchitis 30.2 TNF IL10 CRP CD40LG
35 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.1 IL17A IL10 IFNG
36 vasculitis 30.1 TNF LCN2 IL17A CRP CD40LG
37 granulomatous hepatitis 30.1 GPT CRP CD40LG
38 infective endocarditis 30.1 TNF TLR2 IL17A CRP
39 pericardial effusion 30.1 GPT F3 CRP CD40LG
40 papilledema 30.0 F3 CRP CD40LG
41 hepatorenal syndrome 30.0 LCN2 IL18 HAVCR1 GPT
42 purpura 30.0 TNF IL10 F3 CRP CD40LG
43 encephalitis 29.9 TNF IL1B IL10 IDO1 CD40LG
44 acute pancreatitis 29.9 TNF TLR4 IL1B IL18 IL10 GPT
45 polyneuropathy 29.9 TNF IL1B CRP CD40LG
46 hepatitis e 29.9 TNF IFNG GPT CD40LG
47 gastritis 29.9 TNF TLR4 IL1B IL17A IL10
48 brain edema 29.8 IL1B IFNG CRP
49 viral meningitis 29.8 IFNG CRP CD40LG
50 bacterial sepsis 29.7 TNF TLR4 TLR2 IL18 IL10 CRP

Graphical network of the top 20 diseases related to Scrub Typhus:



Diseases related to Scrub Typhus

Symptoms & Phenotypes for Scrub Typhus

Human phenotypes related to Scrub Typhus:

58 31 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperhidrosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0000975
2 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
3 skin rash 58 31 hallmark (90%) Very frequent (99-80%) HP:0000988
4 myalgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0003326
5 cough 58 31 hallmark (90%) Very frequent (99-80%) HP:0012735
6 lethargy 58 31 hallmark (90%) Very frequent (99-80%) HP:0001254
7 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002017
8 hypotension 58 31 frequent (33%) Frequent (79-30%) HP:0002615
9 photophobia 58 31 frequent (33%) Frequent (79-30%) HP:0000613
10 abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002027
11 macule 58 31 frequent (33%) Frequent (79-30%) HP:0012733
12 gangrene 58 31 frequent (33%) Frequent (79-30%) HP:0100758
13 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
14 lymphadenopathy 58 31 frequent (33%) Frequent (79-30%) HP:0002716
15 anterior uveitis 58 31 frequent (33%) Frequent (79-30%) HP:0012122
16 seizures 58 31 occasional (7.5%) Occasional (29-5%) HP:0001250
17 tremor 58 31 occasional (7.5%) Occasional (29-5%) HP:0001337
18 encephalitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002383
19 splenomegaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0001744
20 renal insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0000083
21 dyspnea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002094
22 abnormal bleeding 58 31 occasional (7.5%) Occasional (29-5%) HP:0001892
23 restrictive ventilatory defect 58 31 occasional (7.5%) Occasional (29-5%) HP:0002091
24 myocarditis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012819
25 meningitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001287
26 behavioral abnormality 58 Occasional (29-5%)
27 reduced consciousness/confusion 58 Very frequent (99-80%)

GenomeRNAi Phenotypes related to Scrub Typhus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 CD40LG IL10 IL17A IL18 IL1B LCN2
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 CD40LG IL10 IL17A IL18 IL1B LCN2

MGI Mouse Phenotypes related to Scrub Typhus:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.32 CD40LG CRP F3 IDO1 IFNG IL10
2 homeostasis/metabolism MP:0005376 10.28 CD40LG CRP F3 IDO1 IFNG IL10
3 hematopoietic system MP:0005397 10.27 CD40LG F3 IDO1 IFNG IL10 IL15
4 growth/size/body region MP:0005378 10.26 F3 IFNG IL10 IL15 IL17A IL18
5 immune system MP:0005387 10.25 CD40LG CRP F3 IDO1 IFNG IL10
6 cellular MP:0005384 10.24 CD40LG F3 IDO1 IFNG IL10 IL18
7 mortality/aging MP:0010768 10.13 CD40LG F3 IFNG IL10 IL15 IL17A
8 integument MP:0010771 10.07 CD40LG F3 IFNG IL10 IL17A IL18
9 muscle MP:0005369 9.86 F3 IDO1 IFNG IL10 IL18 TLR2
10 neoplasm MP:0002006 9.7 F3 IFNG IL10 IL1B TLR2 TLR4
11 renal/urinary system MP:0005367 9.56 CD40LG IDO1 IFNG IL15 IL17A LCN2
12 skeleton MP:0005390 9.28 CD40LG GPT IFNG IL10 IL17A IL1B

Drugs & Therapeutics for Scrub Typhus

Drugs for Scrub Typhus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2 Antibiotics, Antitubercular Phase 4
3 Antitubercular Agents Phase 4
4
Telithromycin Approved Phase 3 191114-48-4 5462516 70789201
5
Azithromycin Approved Phase 3 83905-01-5 55185 447043
6
Sulfamethoxazole Approved Phase 3 723-46-6 5329
7
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
8 Anti-Infective Agents Phase 3
9 Antiparasitic Agents Phase 3
10 Anti-Bacterial Agents Phase 3
11 Antiprotozoal Agents Phase 3
12 Antimalarials Phase 3
13 Renal Agents Phase 3
14 Anti-Infective Agents, Urinary Phase 3
15 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
16
Rifampicin Approved 13292-46-1 5458213 5381226
17
Ethanol Approved 64-17-5 702
18
carbamide peroxide Approved 124-43-6
19 Cytochrome P-450 CYP3A Inducers
20 Vaccines
21 Immunoglobulins
22 Antibodies

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 The Scrub Typhus Antibiotic Resistance Trial (START) Comparing Doxycycline and Azithromycin Treatment Modalities in Areas of Reported Antimicrobial Resistance for Scrub Typhus Recruiting NCT03083197 Phase 4 Doxycycline 7 days;Doxycycline 3 days;Azithromycin 3 days
2 Phase 3 Study of Controlled Trial: 5-day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00351182 Phase 3 Telithromycin;Doxycycline
3 Parallel Group, Double Blinded, 1:1, Randomized Controlled Phase III Trial of Co-trimoxazole Versus Azithromycin for the Treatment of Undifferentiated Fever In Nepal Active, not recruiting NCT02773407 Phase 3 Azithromycin;Co-trimoxazole
4 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
5 Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00568711 doxycycline;rifampin
6 The Natural Immune Response In Pediatric Scrub Typhus In Chiangrai Completed NCT02398162
7 Rickettsial Disease in Febrile Hospitalised Patients in a Tertiary Referral Hospital in Bangladesh Completed NCT02339259
8 Indian Intensive Care Case Mix and Practice Patterns Study Completed NCT01384929
9 Prediction and Early Diagnosis for Cardiovascular Disease Complicated by Scrub Typhus Infection Recruiting NCT03274869
10 Eschar Investigations to Improve Diagnostics, Understand Early Immune Responses and Characterize Strains for Vaccines in Scrub Typhus Recruiting NCT02915861
11 A Multicentre Observational Study to Describe the Prevalence of Scrub Typhus Defined as a Positive Rapid Diagnostic Test Among Selected Patients Presenting With Fever to Clinics in Myanmar Active, not recruiting NCT03269266
12 The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents Active, not recruiting NCT02876367
13 Background Seroprevalence of Rickettsial Infections in Myanmar Not yet recruiting NCT03847870

Search NIH Clinical Center for Scrub Typhus

Cochrane evidence based reviews: scrub typhus

Genetic Tests for Scrub Typhus

Anatomical Context for Scrub Typhus

MalaCards organs/tissues related to Scrub Typhus:

40
Testes, T Cells, Liver, Heart, Kidney, Lung, Skin

Publications for Scrub Typhus

Articles related to Scrub Typhus:

(show top 50) (show all 1771)
# Title Authors PMID Year
1
Does IL-17 play a role in hepatic dysfunction of scrub typhus patients? 54 61
19485773 2010
2
The difference in clinical characteristics between acute Q fever and scrub typhus in southern Taiwan. 54 61
18977677 2009
3
Comparison of indirect immunofluorescence assays for diagnosis of scrub typhus and murine typhus using venous blood and finger prick filter paper blood spots. 54 61
19407134 2009
4
Hepatic dysfunction in pediatric scrub typhus: role of liver function test in diagnosis and marker of disease severity. 54 61
18181321 2007
5
Scrub typhus among hospitalised patients with febrile illness in South India: magnitude and clinical predictors. 54 61
16368461 2006
6
Evaluation of an immunoglobulin M capture enzyme-linked immunosorbent assay for diagnosis of Orientia tsutsugamushi infection. 54 61
12738637 2003
7
Early diagnosis of scrub typhus with a rapid flow assay using recombinant major outer membrane protein antigen (r56) of Orientia tsutsugamushi. 54 61
11238230 2001
8
Serological reactivity of sera from scrub typhus patients against Weil-Felix test antigens. 54 61
8133798 1993
9
The epidemiology, characteristics and outbreaks of human leptospirosis and the association with animals in Taiwan, 2007-2014: A nationwide database study. 61
31916706 2020
10
Antinuclear antibodies in infectious diseases. 61
31718355 2020
11
"Coinfection of H1N1 Influenza and Scrub Typhus: A Review". 61
32031635 2020
12
Searching and finding the hidden treasure: Rickettsial disease among Dutch international travelers - a retrospective analysis. 61
31998942 2020
13
Obligate intracellular bacteria diversity in unfed Leptotrombidium scutellare larvae highlights novel bacterial endosymbionts of mites. 61
31549736 2020
14
Temporal analysis of mRNA expression profiles in Orientia infected C3HeB/FeJ mouse. 61
31906849 2020
15
A study on clinical features and treatment outcome of scrub typhus a re-emerging disease in a tertiary care hospital in eastern India. 61
31979881 2020
16
Identification of trombiculid mites (Acari: Trombiculidae) on rodents from Chiloé Island and molecular evidence of infection with Orientia species. 61
31971956 2020
17
Outcome Predictors in Scrub Typhus Requiring Ventilator and Vasopressor Support. 61
32001853 2020
18
Scrub typhus with meningoencephalitis - four cases. 61
31979815 2020
19
Pancytopenia- A rare manifestation of scrub typhus. 61
31979876 2020
20
Study of Scrub Typhus in Rural Bangalore. 61
31979888 2020
21
Massive splenomegaly in scrub typhus: A rare presentation. 61
31908944 2020
22
Role of Bone Marrow Examination in the Evaluation of Infections: Clinico-Hematological Analysis in a Tertiary Care Centre. 61
31522489 2020
23
Scrub Typhus Eschar. 61
31937716 2020
24
Spatiotemporal and demographic characteristics of scrub typhus in Southwest China, 2006-2017: An analysis of population-based surveillance data. 61
31975551 2020
25
Extracellular vesicle-associated antigens as a new vaccine platform against scrub typhus. 61
31941602 2020
26
A cutaneous clue to a tropical cause of acute pancreatitis: Scrub Typhus. 61
31927109 2020
27
Invasive plants facilitated by socioeconomic change harbor vectors of scrub typhus and spotted fever. 61
31961870 2020
28
Clinical and Biochemical Profi le of Scrub Typhus: A Re-Emerging Infection in Western Odisha. 61
31979814 2020
29
Complex Cytokine Responses in Imported Scrub Typhus Cases, Germany, 2010-2018. 61
31769398 2020
30
Metagenomic next-generation sequencing helped diagnose scrub typhus without eschar: A case report. 61
31648003 2020
31
Hospital based serological evidence of rickettsial diseases and assessment diagnostic tests of pyrexia of unknown origin. 61
31805833 2019
32
The Eschar Size and Early Inoculation Lesion of Tsutsugamushi Disease on Jeju Island, Korea. 61
31782274 2019
33
Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2. 61
31822267 2019
34
[Feasibility of difference between hematocrit and albumin for identifying severity of scrub typhus disease]. 61
32029042 2019
35
Scrub typhus in patients with acute febrile illness: a five-year study from India. 61
31790119 2019
36
Coinfection of Severe Fever with Thrombocytopenia Syndrome and Scrub Typhus in Patients with Tick-Borne Illness. 61
31549609 2019
37
New-onset atrial fibrillation predicting for complicating cardiac adverse outcome in scrub typhus infection. 61
31580531 2019
38
Mapping Environmental Suitability of Scrub Typhus in Nepal Using MaxEnt and Random Forest Models. 61
31810239 2019
39
Spatio-temporal patterns of scrub typhus in mainland China, 2006-2017. 61
31790406 2019
40
Annual Fluctuation in Chigger Mite Populations and Orientia Tsutsugamushi Infections in Scrub Typhus Endemic Regions of South Korea. 61
31897364 2019
41
Challenges in diagnosing scrub typhus among hospitalized patients with undifferentiated fever at a national tertiary hospital in northern Vietnam. 61
31805053 2019
42
Drug-resistant scrub typhus. 61
31837263 2019
43
Drug-resistant scrub typhus. 61
31837262 2019
44
Splenic infarct with scrub typhus: a rare presentation. 61
31789114 2019
45
Antibody response following scrub typhus infection: clinical cohort study. 61
31660667 2019
46
Scrub typhus with multi-organ dysfunction syndrome and immune thrombocytopenia: a case report and review of the literature. 61
31810465 2019
47
Diagnostic tools used in the evaluation of acute febrile illness in South India: a scoping review. 61
31722678 2019
48
Serologic Evidence for Orientia Exposure in the Democratic Republic of Sao Tome and Principe. 61
31407963 2019
49
Comparison of chest radiographic findings between severe fever with thrombocytopenia syndrome and scrub typhus: Single center observational cross-sectional study in South Korea. 61
31725613 2019
50
Severe Fever with Thrombocytopenia Syndrome Virus Infection or Mixed Infection with Scrub Typhus in South Korea in 2000-2003. 61
31482787 2019

Variations for Scrub Typhus

Expression for Scrub Typhus

Search GEO for disease gene expression data for Scrub Typhus.

Pathways for Scrub Typhus

Pathways related to Scrub Typhus according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 TNF TLR4 TLR2 LCN2 IL1B IL18
2
Show member pathways
13.7 TNF TLR4 IL1B IL18 IL17A IL15
3
Show member pathways
13.45 TNF TLR4 TLR2 IL1B IL18 IL17A
4
Show member pathways
13.4 TNF LCN2 IL1B IL18 IL17A IL15
5
Show member pathways
13.32 TNF IL1B IL18 IL17A IL15 IL10
6
Show member pathways
13.16 TNF TLR4 TLR2 IL1B IL18 IL10
7
Show member pathways
12.91 TNF IL1B IL17A IL15 IL10 IFNG
8
Show member pathways
12.86 TNF TLR4 TLR2 IL1B IL18 IFNG
9
Show member pathways
12.78 TNF TLR4 IL1B IL18 IFNG
10
Show member pathways
12.73 TNF TLR4 TLR2 IL1B CD40LG
11
Show member pathways
12.68 TNF TLR4 TLR2 IL1B IL17A IL10
12
Show member pathways
12.66 TNF IL18 IL10 IFNG CD40LG
13
Show member pathways
12.66 TNF TLR4 TLR2 IL1B IL18 IL17A
14
Show member pathways
12.65 TNF IL1B IL18 IL17A IL10 IFNG
15
Show member pathways
12.62 TNF TLR4 TLR2 IL1B CD40LG
16 12.6 TNF TLR2 IL1B IL17A IL10 IFNG
17 12.4 TNF TLR4 IL1B IL18
18
Show member pathways
12.4 TNF TCN2 IL1B IFNG CRP
19
Show member pathways
12.4 TNF TLR2 LCN2 IL1B IL17A IFNG
20
Show member pathways
12.33 TNF IL1B IL18 IL17A IL15 IL10
21
Show member pathways
12.33 TNF TLR4 TLR2 IL1B IL10 IFNG
22
Show member pathways
12.32 TNF TLR4 IL1B IFNG
23 12.32 TNF TLR4 IL1B IL18
24
Show member pathways
12.29 TNF TLR2 IL1B IL18 F3
25 12.29 TNF TLR4 TLR2 IL1B IL18 IL10
26 12.26 TNF TLR4 IL1B IL18
27
Show member pathways
12.25 TNF TLR4 TLR2 IL1B IFNG
28
Show member pathways
12.24 TNF TLR4 IL1B IFNG
29 12.22 TNF TLR4 TLR2 IFNG
30
Show member pathways
12.11 TNF TLR4 TLR2 IL1B IFNG
31 12.09 TNF LCN2 IL1B IL18 IL17A IL10
32 12.08 TNF TLR4 IL1B IL18 IL10
33 12.07 TNF TLR4 IL1B IFNG
34 12.05 TNF IL15 IL10 IFNG
35 12.03 TNF TLR4 TLR2 IL1B IL10 IFNG
36 11.99 TNF TLR4 IL1B CD40LG
37 11.87 TLR4 IL1B IL18 IFNG
38
Show member pathways
11.87 TNF TLR4 TLR2 IL1B IL18 IL17A
39 11.84 TNF TLR4 IL1B IL10
40 11.83 TNF IL1B IL10 IFNG
41 11.82 TNF IL1B IL18 IL17A IL15 IL10
42
Show member pathways
11.78 TNF IFNG CD40LG
43
Show member pathways
11.75 TNF IL1B IFNG CD40LG
44 11.72 TNF TLR4 TLR2 IL1B IL18
45 11.65 TNF IL1B IL18 IL17A IL15 IL10
46 11.62 TNF TLR4 TLR2 IL1B IL18 IFNG
47 11.61 TNF IL1B IL18 IL10
48 11.56 TNF IL1B IFNG
49 11.53 TNF TLR4 TLR2 IL1B IL18 IL17A
50 11.52 TNF IL1B IFNG

GO Terms for Scrub Typhus

Cellular components related to Scrub Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TNF TCN2 LCN2 IL1B IL18 IL17A
2 cell surface GO:0009986 9.63 TNF TLR4 TLR2 IL15 F3 CD40LG
3 extracellular space GO:0005615 9.44 TNF TCN2 LCN2 IL1B IL18 IL17A

Biological processes related to Scrub Typhus according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.24 TNF TLR4 TLR2 IL1B IL18 IL17A
2 defense response to bacterium GO:0042742 10.03 TNF TLR4 LCN2 IL10
3 cell-cell signaling GO:0007267 10.02 IL1B IL18 IL17A IL15
4 cytokine-mediated signaling pathway GO:0019221 10.02 TNF LCN2 IL1B IL18 IL17A IL10
5 positive regulation of gene expression GO:0010628 10.01 TNF TLR4 TLR2 LCN2 IL1B IL18
6 cellular response to lipopolysaccharide GO:0071222 10 TNF TLR4 LCN2 IL1B IL10
7 response to lipopolysaccharide GO:0032496 9.99 TLR4 TLR2 IL1B IL10 IDO1
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 TNF TLR4 TLR2 IL1B IL18 CD40LG
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.92 TNF IL18 IL15 IFNG
10 positive regulation of JNK cascade GO:0046330 9.9 TNF TLR4 IL1B
11 cellular response to organic cyclic compound GO:0071407 9.89 TNF IL1B IL18
12 regulation of insulin secretion GO:0050796 9.89 TNF IL1B IFNG
13 positive regulation of T cell proliferation GO:0042102 9.88 IL1B IL15 CD40LG
14 positive regulation of interleukin-6 production GO:0032755 9.88 TNF TLR4 TLR2 IL1B
15 negative regulation of interleukin-6 production GO:0032715 9.85 TNF TLR4 IL10
16 positive regulation of phagocytosis GO:0050766 9.85 TNF IL1B IL15 IFNG
17 microglial cell activation GO:0001774 9.84 TNF TLR2 IFNG
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.84 TNF TLR4 IL1B IFNG
19 positive regulation of interferon-gamma production GO:0032729 9.83 TNF TLR4 IL1B IL18
20 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.83 TNF TLR4 TLR2 IL1B IL18
21 positive regulation of interleukin-10 production GO:0032733 9.82 TLR4 TLR2 CD40LG
22 positive regulation of osteoclast differentiation GO:0045672 9.81 TNF IL17A IFNG
23 positive regulation of chemokine production GO:0032722 9.81 TNF TLR4 TLR2
24 positive regulation of interleukin-8 production GO:0032757 9.81 TNF TLR4 TLR2 IL1B
25 astrocyte activation GO:0048143 9.8 TNF IL1B IFNG
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.79 TNF IL1B IFNG
27 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.79 TNF IL1B IL10
28 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.78 TLR4 TLR2 IFNG
29 positive regulation of interleukin-6 secretion GO:2000778 9.77 TNF TLR4 TLR2 IL1B IL17A
30 positive regulation of neuroinflammatory response GO:0150078 9.75 TNF IL1B IL18
31 positive regulation of chemokine biosynthetic process GO:0045080 9.74 TNF IL1B IFNG
32 neutrophil activation GO:0042119 9.73 IL18 IL15
33 I-kappaB phosphorylation GO:0007252 9.73 TLR4 TLR2
34 response to molecule of bacterial origin GO:0002237 9.73 TLR2 IL10
35 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.73 IL1B IL18
36 positive regulation of MHC class II biosynthetic process GO:0045348 9.73 TLR4 IL10 IFNG
37 positive regulation of inflammatory response GO:0050729 9.73 TNF TLR4 TLR2 IL1B IL18 IL15
38 negative regulation of amyloid-beta clearance GO:1900222 9.72 TNF IFNG
39 cellular response to lipoteichoic acid GO:0071223 9.72 TLR4 TLR2
40 T-helper 1 type immune response GO:0042088 9.72 TLR4 IL18
41 negative regulation of lipid storage GO:0010888 9.72 TNF CRP
42 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 TNF TLR4 TLR2 IL1B IL18
43 endothelial cell apoptotic process GO:0072577 9.71 TNF IL10
44 regulation of defense response to virus by host GO:0050691 9.71 IL1B IL15
45 positive regulation of natural killer cell proliferation GO:0032819 9.71 IL18 IL15
46 regulation of establishment of endothelial barrier GO:1903140 9.7 TNF IL1B
47 interleukin-6 production GO:0032635 9.7 IL1B IL18
48 positive regulation of tissue remodeling GO:0034105 9.69 IL18 IL15
49 negative regulation of cytokine secretion involved in immune response GO:0002740 9.69 TNF IL10
50 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.69 IL1B IL18

Molecular functions related to Scrub Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 TNF IL1B IL18 IL17A IL15 IL10
2 lipopolysaccharide receptor activity GO:0001875 8.96 TLR4 TLR2

Sources for Scrub Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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