MCID: SBC011
MIFTS: 43

Sebaceous Adenocarcinoma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Sebaceous Adenocarcinoma

MalaCards integrated aliases for Sebaceous Adenocarcinoma:

Name: Sebaceous Adenocarcinoma 12 15 17 72
Sebaceous Carcinoma 12 15
Adenocarcinoma of the Sebaceous Gland 12
Malignant Neoplasm of Sebaceous Gland 12
Malignant Sebaceous Neoplasm 72
Malignant Sebaceous Tumor 12
Sebaceous Gland Neoplasms 72
Adenocarcinoma, Sebaceous 44

Classifications:



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Disease Ontology 12 DOID:4839 DOID:4840
MeSH 44 D018266
NCIt 50 C40310 C8409
SNOMED-CT 68 54734006
ICD10 33 C44
UMLS 72 C0036503 C0206684 C1382026

Summaries for Sebaceous Adenocarcinoma

MalaCards based summary : Sebaceous Adenocarcinoma, also known as sebaceous carcinoma, is related to meibomian cyst and lipid-rich carcinoma. An important gene associated with Sebaceous Adenocarcinoma is MLH1 (MutL Homolog 1), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Endometrial cancer. The drugs Talimogene laherparepvec and nivolumab have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and salivary gland, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Synthetic lethal with vaccinia virus (VACV) infection

Related Diseases for Sebaceous Adenocarcinoma

Diseases related to Sebaceous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 meibomian cyst 30.4 PLIN2 AR
2 lipid-rich carcinoma 30.1 PLIN2 KRT5
3 sebaceous adenoma 29.9 PMS2 MSH6 MSH2 MLH1
4 colorectal adenocarcinoma 29.9 MSH6 MSH2 MLH1
5 apocrine adenocarcinoma 29.8 KRT5 AR
6 skin benign neoplasm 29.4 MSH6 MSH2 MLH1 KRT5
7 lynch syndrome 28.6 PMS2 PMS1 MSH6 MSH2 MLH1
8 mismatch repair cancer syndrome 28.1 PMS2 PMS1 MSH6 MSH2 MLH1
9 muir-torre syndrome 27.7 PMS2 PMS1 PLIN2 MSH6 MSH2 MLH1
10 vulvar sebaceous carcinoma 12.5
11 eyelid carcinoma 10.7
12 basal cell carcinoma 10.6
13 adenocarcinoma 10.5
14 colorectal cancer, hereditary nonpolyposis, type 7 10.4 MSH2 MLH1
15 lower lip cancer 10.4 MSH2 MLH1
16 anal fistula 10.4 MSH2 MLH1
17 melanocytic nevus syndrome, congenital 10.4 MSH2 MLH1
18 in situ carcinoma 10.4
19 colorectal cancer 5 10.4 MSH6 MLH1
20 spindle cell intraocular melanoma 10.4 PMS2 MLH1
21 gastric leiomyoma 10.4 MSH6 MLH1
22 childhood kidney cell carcinoma 10.3 MSH2 MLH1
23 attenuated familial adenomatous polyposis 10.3 MSH6 MSH2
24 intestinal benign neoplasm 10.3 MSH2 MLH1
25 cystic teratoma 10.3
26 teratoma 10.3
27 adenoma 10.3
28 keratoacanthoma 10.3 MSH2 MLH1
29 conjunctivitis 10.3
30 legius syndrome 10.2 MSH6 MSH2
31 keratosis 10.2
32 mature teratoma 10.2
33 mammary paget's disease 10.2
34 familial colorectal cancer 10.2 MSH2 MLH1
35 actinic keratosis 10.2
36 bowen's disease 10.2
37 colorectal adenoma 10.1 MSH2 MLH1
38 breast cancer 10.1
39 squamous cell carcinoma 10.1
40 dermoid cyst 10.1
41 skin carcinoma 10.1
42 hidradenoma 10.1
43 pleomorphic adenoma 10.1
44 clear cell hidradenoma 10.1
45 syringocystadenoma papilliferum 10.1
46 colorectal cancer, hereditary nonpolyposis, type 5 10.1 MSH6 MSH2 MLH1
47 retinoblastoma 10.1
48 ptosis 10.1
49 merkel cell carcinoma 10.1
50 familial retinoblastoma 10.1

Graphical network of the top 20 diseases related to Sebaceous Adenocarcinoma:



Diseases related to Sebaceous Adenocarcinoma

Symptoms & Phenotypes for Sebaceous Adenocarcinoma

GenomeRNAi Phenotypes related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.35 MLH1 MSH2 MSH6 PMS1 PMS2
2 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.92 MLH1 MSH6 PMS2 PRF1

MGI Mouse Phenotypes related to Sebaceous Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.87 AR MLH1 MSH2 MSH6 PLIN2 PMS2
2 immune system MP:0005387 9.8 AR MLH1 MSH2 MSH6 PLIN2 PMS2
3 digestive/alimentary MP:0005381 9.77 AR KRT5 MLH1 MSH2 PMS2
4 integument MP:0010771 9.7 AR KRT5 MLH1 MSH2 MSH6 PLIN2
5 mortality/aging MP:0010768 9.5 AR KRT5 MLH1 MSH2 MSH6 PMS2
6 neoplasm MP:0002006 9.17 AR MLH1 MSH2 MSH6 PMS1 PMS2

Drugs & Therapeutics for Sebaceous Adenocarcinoma

Drugs for Sebaceous Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
2
nivolumab Approved Phase 2 946414-94-4
3 Technetium Tc 99m Sulfur Colloid Phase 2
4 Radiopharmaceuticals Phase 2
5 Anesthetics Phase 2
6 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sentinel Lymph Node Localization and Biopsy for Sebaceous Gland Carcinoma of the Eyelid Recruiting NCT00832429 Phase 2 Tc99m-Sulfur colloid
2 A Phase II Study of Talimogene Laherparepvec Followed by Talimogene Laherparepvec + Nivolumab in Refractory T Cell and NK Cell Lymphomas, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma, and Other Rare Skin Tumors Suspended NCT02978625 Phase 2

Search NIH Clinical Center for Sebaceous Adenocarcinoma

Cochrane evidence based reviews: adenocarcinoma, sebaceous

Genetic Tests for Sebaceous Adenocarcinoma

Anatomical Context for Sebaceous Adenocarcinoma

MalaCards organs/tissues related to Sebaceous Adenocarcinoma:

41
Skin, Breast, Salivary Gland, Lymph Node, Ovary, Lung, Cervix

Publications for Sebaceous Adenocarcinoma

Articles related to Sebaceous Adenocarcinoma:

(show top 50) (show all 729)
# Title Authors PMID Year
1
Potentially actionable FGFR2 high-level amplification in thymic sebaceous carcinoma. 38
31401665 2019
2
Superficial sebaceous carcinoma: The correlations between the clinical, dermoscopic and histopathological findings of a rare variant of sebaceous carcinoma. 38
30860621 2019
3
[Sebaceous carcinoma in situ in extraocular skin : Case report and discussion of the new entity]. 38
31420711 2019
4
Impact of clinicopathologic factors on survival in patients with sebaceous carcinoma of the eyelid - a population-based analysis. 38
30373440 2019
5
Prognostic factors for local recurrence, metastasis and survival for sebaceous carcinoma of the eyelid: observations in 100 patients. 38
30131380 2019
6
Radiotherapy for localized sebaceous carcinoma of the eyelid: a retrospective analysis of 83 patients. 38
31271440 2019
7
Re-evaluating the epidemiology of cutaneous sebaceous carcinoma. 38
31328254 2019
8
Lacrimal Sac Sebaceous Carcinoma. 38
30921057 2019
9
Muir-Torre syndrome appropriate use criteria: Effect of patient age on appropriate use scores. 38
30895633 2019
10
PD-1 and PD-L1 inhibitors in the treatment of non-melanoma skin cancer: a systematic review. 38
31163235 2019
11
Regression of Sebaceous Carcinoma of the Eyelid after a Small Incisional Biopsy: Report of Two Cases. 38
31367586 2019
12
Sebaceous carcinoma of the caruncle. 38
31178073 2019
13
Mohs micrographic surgery versus wide local excision for sebaceous adenocarcinoma of the eyelid : Analysis of a national database. 38
30894313 2019
14
Mutations in TP53, ZNF750, and RB1 typify ocular sebaceous carcinoma. 38
31278009 2019
15
Periocular Sebaceous Carcinoma With Apocrine Differentiation: A Case Report and Review of the Literature. 38
30522363 2019
16
[Follow-up of a sebaceous carcinoma of the eyelids: A case report]. 38
31204087 2019
17
Mohs micrographic surgery for eyelid sebaceous carcinoma: A multicenter cohort of 360 patients. 38
30639290 2019
18
Eyelid sebaceous carcinoma: Validation of the 8th edition of the American Joint Committee on cancer T staging system and the prognostic factors for local recurrence, nodal metastasis, and survival. 38
31147618 2019
19
Programmed death receptor Ligand 1 expression in eyelid sebaceous carcinoma: a consecutive case series of 41 patients. 38
29862664 2019
20
Loss of ZNF750 in ocular and cutaneous sebaceous carcinoma. 38
31148199 2019
21
Ocular sebaceous gland carcinoma: an update of the literature. 38
29696467 2019
22
Sebaceous carcinoma of the penis: As aggressive as it is rare. 38
31040615 2019
23
[Ⅲ.Topics in Histopathological Diagnosis and Classification of Cutaneous Sebaceous Carcinoma]. 38
31164502 2019
24
Pedunculated poorly differentiated papillary sebaceous carcinoma of the eyelid. 38
31020881 2019
25
The practice patterns in the management of sebaceous carcinoma of the eyelid in the Asia Pacific region. 38
30952958 2019
26
Predictors of Local Recurrence for Eyelid Sebaceous Carcinoma: Questionable Value of Routine Conjunctival Map Biopsies for Detection of Pagetoid Spread. 38
30865067 2019
27
Spatial analysis of p63, K5 and K7 defines two groups of progenitor cells that differentially contribute to the maintenance of normal sebaceous glands, extraocular sebaceous carcinoma and benign sebaceous tumors. 38
30663115 2019
28
Merkel cells in extraocular sebaceous carcinoma. 38
30362151 2019
29
Muir-Torre Syndrome Presenting as a Sebaceous Carcinoma of the Nasal Ala. 38
30947781 2019
30
Super-Thick Amniotic Membrane Graft for Ocular Surface Reconstruction. 38
30312574 2019
31
Distinct Biological Types of Ocular Adnexal Sebaceous Carcinoma: HPV-Driven and Virus-Negative Tumors Arise through Nonoverlapping Molecular-Genetic Alterations. 38
30420449 2019
32
Comparison of Mohs Surgery and Surgical Excision in the Treatment of Localized Sebaceous Carcinoma. 38
30829780 2019
33
Successful Treatment with Taxane-Based Chemotherapy in Advanced Sebaceous Carcinoma: A Case Report and Literature Review. 38
30792644 2019
34
Sebaceous Carcinoma of the Nose: A Rare Presentation of an Uncommon Tumor. 38
30996765 2019
35
Frequent TLE1 Expression in Cutaneous Neoplasms. 38
30608261 2019
36
Change in Eyelid Carcinoma T Category With Use of the 8th Versus 7th Edition of the American Joint Committee on Cancer: Cancer Staging Manual. 38
29877957 2019
37
Impact of Muir-Torre Syndrome on Survival in Patients With Sebaceous Carcinoma: A SEER Population-Based Study. 38
29578884 2019
38
Mismatch repair deficiency is implicated in carcinoma arising from ovarian teratoma. 38
30502217 2019
39
Sebaceous Carcinoma of Upper Eyelid Presenting as Submandibular Lymphadenopathy. 38
30745746 2019
40
Primary sebaceous carcinoma of lacrimal gland: A case report and review of literature. 38
30613681 2018
41
Bowen Disease With Sebaceous Differentiation: A Case Report and Immunohistochemical Analysis of Adipophilin and Cytokeratin 1. 38
29742561 2018
42
Eyelid sebaceous carcinoma in situ presenting as haemorrhagic cyst. 38
29797387 2018
43
Sebaceous tumours: more than skin deep. 38
29247065 2018
44
Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation. 38
30225334 2018
45
Malignant Transformation of Mature Cystic Teratoma: Is Squamous Cell Carcinoma Different From the Other Types of Neoplasm? 38
30358706 2018
46
Sebaceous adenocarcinomas of the major salivary glands: a clinicopathological analysis of 10 cases. 38
29856905 2018
47
A Case Report of Recurrent Metastatic Sebaceous Carcinoma Which Showed Favorable Response Tt Non-Fluorouracil Based Chemotherapy. 38
30291222 2018
48
Sebaceous carcinoma in a mature teratoma of the ovary. 38
30775330 2018
49
Contemporary update of overall prognosis and nomogram to predict individualized survival for Chinese patients with eyelid sebaceous carcinoma. 38
30236450 2018
50
Comparison of posterior lamellar resection versus lumpectomy for initial management of localized tarsal conjunctival sebaceous carcinoma in 54 cases. 38
30127144 2018

Variations for Sebaceous Adenocarcinoma

Expression for Sebaceous Adenocarcinoma

Search GEO for disease gene expression data for Sebaceous Adenocarcinoma.

Pathways for Sebaceous Adenocarcinoma

Pathways related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 PMS2 MSH6 MSH2 MLH1
2
Show member pathways
12.48 MSH6 MSH2 MLH1 AR
3 12.39 MSH6 MSH2 MLH1 AR
4 12.17 MSH6 MSH2 MLH1
5 11.8 MSH6 MSH2 MLH1
6 11.69 MSH6 MSH2 AR
7 11.55 PMS2 MSH2 MLH1
8 11.23 MSH6 MSH2 MLH1
9 11.2 MSH6 MSH2 MLH1
10 11.17 MSH6 MSH2
11
Show member pathways
11.14 MSH2 MLH1
12
Show member pathways
11.08 MSH2 MLH1
13
Show member pathways
11 PMS2 PMS1 MSH6 MSH2 MLH1
14 10.72 PMS2 MSH6 MSH2 MLH1

GO Terms for Sebaceous Adenocarcinoma

Cellular components related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.86 PMS2 PMS1 PLIN2 MSH6 MSH2 MLH1
2 MutSalpha complex GO:0032301 9.16 MSH6 MSH2
3 MutLalpha complex GO:0032389 9.13 PMS2 PMS1 MLH1
4 mismatch repair complex GO:0032300 9.02 PMS2 PMS1 MSH6 MSH2 MLH1

Biological processes related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.8 PMS2 PMS1 MSH6 MSH2 MLH1
2 response to drug GO:0042493 9.75 PMS2 PMS1 PLIN2
3 DNA repair GO:0006281 9.72 PMS2 PMS1 MSH6 MSH2 MLH1
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.61 MSH6 MSH2 MLH1
5 negative regulation of DNA recombination GO:0045910 9.56 MSH6 MSH2
6 determination of adult lifespan GO:0008340 9.55 MSH6 MSH2
7 positive regulation of isotype switching to IgG isotypes GO:0048304 9.54 MSH2 MLH1
8 positive regulation of helicase activity GO:0051096 9.52 MSH6 MSH2
9 positive regulation of isotype switching to IgA isotypes GO:0048298 9.49 MSH2 MLH1
10 maintenance of DNA repeat elements GO:0043570 9.48 MSH6 MSH2
11 isotype switching GO:0045190 9.43 MSH6 MSH2 MLH1
12 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.37 MSH2 MLH1
13 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MSH6 MSH2 MLH1
14 interstrand cross-link repair GO:0036297 9.27 MSH6
15 somatic hypermutation of immunoglobulin genes GO:0016446 9.26 PMS2 MSH6 MSH2 MLH1
16 pyrimidine dimer repair GO:0006290 9.21 MSH6
17 meiotic mismatch repair GO:0000710 9.16 MSH6
18 mismatch repair GO:0006298 9.02 PMS2 PMS1 MSH6 MSH2 MLH1

Molecular functions related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.92 PMS2 PMS1 MSH6 MSH2 MLH1
2 chromatin binding GO:0003682 9.8 MSH6 MSH2 MLH1 AR
3 enzyme binding GO:0019899 9.72 PMS1 MSH6 MSH2 MLH1 AR
4 damaged DNA binding GO:0003684 9.56 MSH6 MSH2
5 DNA-dependent ATPase activity GO:0008094 9.55 MSH6 MSH2
6 ATPase activity GO:0016887 9.55 PMS2 PMS1 MSH6 MSH2 MLH1
7 ADP binding GO:0043531 9.54 MSH6 MSH2
8 four-way junction DNA binding GO:0000400 9.51 MSH6 MSH2
9 oxidized purine DNA binding GO:0032357 9.48 MSH6 MSH2
10 MutSalpha complex binding GO:0032407 9.46 PMS2 MLH1
11 MutLalpha complex binding GO:0032405 9.43 MSH6 MSH2
12 single-stranded DNA binding GO:0003697 9.43 PMS2 MSH2 MLH1
13 single thymine insertion binding GO:0032143 9.4 MSH6 MSH2
14 single guanine insertion binding GO:0032142 9.37 MSH6 MSH2
15 guanine/thymine mispair binding GO:0032137 9.13 MSH6 MSH2 MLH1
16 mismatched DNA binding GO:0030983 9.02 PMS2 PMS1 MSH6 MSH2 MLH1

Sources for Sebaceous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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