MCID: SBC011
MIFTS: 48

Sebaceous Adenocarcinoma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Sebaceous Adenocarcinoma

MalaCards integrated aliases for Sebaceous Adenocarcinoma:

Name: Sebaceous Adenocarcinoma 12 15 17 74
Sebaceous Carcinoma 12 15
Adenocarcinoma of the Sebaceous Gland 12
Malignant Neoplasm of Sebaceous Gland 12
Malignant Sebaceous Neoplasm 74
Malignant Sebaceous Tumor 12
Sebaceous Gland Carcinoma 30
Sebaceous Gland Neoplasms 74
Adenocarcinoma, Sebaceous 45

Classifications:



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Disease Ontology 12 DOID:4839 DOID:4840
MeSH 45 D018266
NCIt 51 C40310 C8409
SNOMED-CT 69 54734006
ICD10 34 C44

Summaries for Sebaceous Adenocarcinoma

MalaCards based summary : Sebaceous Adenocarcinoma, also known as sebaceous carcinoma, is related to meibomian cyst and colorectal adenocarcinoma. An important gene associated with Sebaceous Adenocarcinoma is MLH1 (MutL Homolog 1), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Endometrial cancer. The drugs nivolumab and Talimogene laherparepvec have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and ovary, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Synthetic lethal with vaccinia virus (VACV) infection

Related Diseases for Sebaceous Adenocarcinoma

Diseases related to Sebaceous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 meibomian cyst 30.0 AR PLIN2
2 colorectal adenocarcinoma 29.9 MLH1 MSH2 MSH6
3 sebaceous adenoma 29.6 MLH1 MSH2 MSH6 PMS2
4 mismatch repair cancer syndrome 28.7 MLH1 MSH2 MSH6 PMS1 PMS2
5 muir-torre syndrome 28.5 MLH1 MSH2 MSH6 PLIN2 PMS1 PMS2
6 vulvar sebaceous carcinoma 12.2
7 eyelid carcinoma 10.6
8 adenocarcinoma 10.5
9 colorectal cancer, hereditary nonpolyposis, type 7 10.3 MLH1 MSH2
10 lower lip cancer 10.3 MLH1 MSH2
11 anal fistula 10.3 MLH1 MSH2
12 teratoma 10.3
13 colorectal cancer 5 10.2 MLH1 MSH6
14 melanocytic nevus syndrome, congenital 10.2 MLH1 MSH2
15 gastric leiomyoma 10.2 MLH1 MSH6
16 spindle cell intraocular melanoma 10.2 MLH1 PMS2
17 childhood kidney cell carcinoma 10.2 MLH1 MSH2
18 attenuated familial adenomatous polyposis 10.2 MSH2 MSH6
19 keratosis 10.2
20 cystic teratoma 10.2
21 in situ carcinoma 10.2
22 intestinal benign neoplasm 10.2 MLH1 MSH2
23 keratoacanthoma 10.2 MLH1 MSH2
24 legius syndrome 10.2 MSH2 MSH6
25 squamous cell carcinoma 10.2
26 familial colorectal cancer 10.1 MLH1 MSH2
27 lipid-rich carcinoma 10.1 KRT5 PLIN2
28 basal cell carcinoma 1 10.1
29 basal cell carcinoma 10.1
30 actinic keratosis 10.1
31 bowen's disease 10.1
32 squamous cell papilloma 10.1
33 papilloma 10.1
34 bilateral retinoblastoma 10.1
35 colorectal adenoma 10.1 MLH1 MSH2
36 adenoma 10.0
37 colorectal cancer, hereditary nonpolyposis, type 5 10.0 MLH1 MSH2 MSH6
38 female reproductive system disease 10.0 MLH1 MSH2 MSH6
39 familial adenomatous polyposis 10.0 MLH1 MSH2 MSH6
40 colorectal cancer, hereditary nonpolyposis, type 4 10.0 MLH1 MSH2 PMS2
41 apocrine adenocarcinoma 10.0 AR KRT5
42 vaginitis 10.0 AR PRF1
43 lymphoma, hodgkin, classic 10.0
44 lymphoma, non-hodgkin, familial 10.0
45 lymphoma 10.0
46 malignant fibroxanthoma 10.0
47 histiocytoma 10.0
48 fibrous histiocytoma 10.0
49 syringocystadenoma papilliferum 10.0
50 mature teratoma 10.0

Graphical network of the top 20 diseases related to Sebaceous Adenocarcinoma:



Diseases related to Sebaceous Adenocarcinoma

Symptoms & Phenotypes for Sebaceous Adenocarcinoma

GenomeRNAi Phenotypes related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.35 MLH1 MSH2 MSH6 PMS1 PMS2
2 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.92 MLH1 MSH6 PMS2 PRF1

MGI Mouse Phenotypes related to Sebaceous Adenocarcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.87 AR MLH1 MSH2 MSH6 PLIN2 PMS2
2 immune system MP:0005387 9.8 AR MLH1 MSH2 MSH6 PLIN2 PMS2
3 digestive/alimentary MP:0005381 9.77 AR KRT5 MLH1 MSH2 PMS2
4 integument MP:0010771 9.7 AR KRT5 MLH1 MSH2 MSH6 PLIN2
5 mortality/aging MP:0010768 9.5 AR KRT5 MLH1 MSH2 MSH6 PMS2
6 neoplasm MP:0002006 9.17 AR MLH1 MSH2 MSH6 PMS1 PMS2

Drugs & Therapeutics for Sebaceous Adenocarcinoma

Drugs for Sebaceous Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
3 Technetium Tc 99m Sulfur Colloid Phase 2
4 Anesthetics Phase 2
5 Radiopharmaceuticals Phase 2
6 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sentinel Lymph Node (SLN) Biopsy for Sebaceous Gland Carcinoma of Eyelid Recruiting NCT00832429 Phase 2 Tc99m-Sulfur colloid
2 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Sebaceous Adenocarcinoma

Cochrane evidence based reviews: adenocarcinoma, sebaceous

Genetic Tests for Sebaceous Adenocarcinoma

Genetic tests related to Sebaceous Adenocarcinoma:

# Genetic test Affiliating Genes
1 Sebaceous Gland Carcinoma 30

Anatomical Context for Sebaceous Adenocarcinoma

MalaCards organs/tissues related to Sebaceous Adenocarcinoma:

42
Skin, Lymph Node, Ovary, Tongue, Cervix, Salivary Gland

Publications for Sebaceous Adenocarcinoma

Articles related to Sebaceous Adenocarcinoma:

(show top 50) (show all 363)
# Title Authors Year
1
Mohs micrographic surgery versus wide local excision for sebaceous adenocarcinoma of the eyelid : Analysis of a national database. ( 30894313 )
2019
2
Mohs micrographic surgery for eyelid sebaceous carcinoma: a multicenter cohort of 360 patients. ( 30639290 )
2019
3
Spatial analysis of p63, K5 and K7 defines two groups of progenitor cells that differentially contribute to the maintenance of normal sebaceous glands, extraocular sebaceous carcinoma and benign sebaceous tumors. ( 30663115 )
2019
4
Sebaceous Carcinoma of Upper Eyelid Presenting as Submandibular Lymphadenopathy. ( 30745746 )
2019
5
Successful Treatment with Taxane-Based Chemotherapy in Advanced Sebaceous Carcinoma: A Case Report and Literature Review. ( 30792644 )
2019
6
Comparison of Mohs Surgery and Surgical Excision in the Treatment of Localized Sebaceous Carcinoma. ( 30829780 )
2019
7
Superficial sebaceous carcinoma: The correlations between the clinical, dermoscopic and histopathological findings of a rare variant of sebaceous carcinoma. ( 30860621 )
2019
8
Predictors of Local Recurrence for Eyelid Sebaceous Carcinoma: Questionable Value of Routine Conjunctival Map Biopsies for Detection of Pagetoid Spread. ( 30865067 )
2019
9
Clinicopathological characteristics of breast sebaceous adenocarcinoma. ( 30509049 )
2018
10
Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation. ( 30225334 )
2018
11
Utility of topical epinephrine for determining the resection range of eyelid sebaceous carcinoma with dermatitis. ( 29788677 )
2018
12
Sebaceous carcinoma in a mature teratoma of the ovary. ( 30775330 )
2018
13
Immunohistochemical markers informing the diagnosis of sebaceous carcinoma and its distinction from its mimics: Adipophilin and factor XIIIa to the rescue? ( 29087003 )
2018
14
Dermoscopic features distinctive for extraocular sebaceous carcinoma. ( 29235655 )
2018
15
Extraocular sebaceous carcinoma accompanied by invasive squamous cell carcinoma: The first case report and consideration of histogenesis. ( 29266386 )
2018
16
Sebaceous carcinoma mimicking a chalazion in a young patient. ( 29287845 )
2018
17
Analysis of hedgehog signaling in periocular sebaceous carcinoma. ( 29423837 )
2018
18
Sebaceous carcinoma of the breast: Histological, cytological, and ultrastructural features. ( 29498454 )
2018
19
Breast sebaceous carcinoma-a rare entity. Clinico-pathological description of two cases and brief review. ( 29556777 )
2018
20
Sebaceous carcinoma of the breast in a patient with a pathogenic BRCA2 (886delGT) mutation - focus on histopathologic and immunohistochemical features. ( 29575201 )
2018
21
Intraoperative Adjunctive Mitomycin C and Cryotherapy for Recurrent Conjunctival Papillary Sebaceous Carcinoma. ( 29681840 )
2018
22
Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma. ( 29760388 )
2018
23
Eyelid sebaceous carcinoma in situ presenting as haemorrhagic cyst. ( 29797387 )
2018
24
Programmed death receptor Ligand 1 expression in eyelid sebaceous carcinoma: a consecutive case series of 41 patients. ( 29862664 )
2018
25
Near complete response to Pembrolizumab in microsatellite-stable metastatic sebaceous carcinoma. ( 29914578 )
2018
26
Carboplatin and Pembrolizumab Chemoimmunotherapy Achieves Remission in Recurrent, Metastatic Sebaceous Carcinoma. ( 29979269 )
2018
27
Updates on the clinical diagnosis and management of ocular sebaceous carcinoma: a brief review of the literature. ( 29983580 )
2018
28
Sebaceous Carcinoma in Situ Masquerading Clinically and Histologically as Paget Disease of the Breast. ( 30110525 )
2018
29
Intraoral Sebaceous Carcinoma: Case Report of a Rare Tumor Emphasizing the Histopathological Differential Diagnosis. ( 30116646 )
2018
30
Comparison of posterior lamellar resection versus lumpectomy for initial management of localized tarsal conjunctival sebaceous carcinoma in 54 cases. ( 30127144 )
2018
31
Prognostic factors for local recurrence, metastasis and survival for sebaceous carcinoma of the eyelid: observations in 100 patients. ( 30131380 )
2018
32
The Usefulness of Dermoscopy in Extraocular Sebaceous Carcinoma. ( 30210176 )
2018
33
High expression of PD-1 and PD-L1 in ocular adnexal sebaceous carcinoma. ( 30228943 )
2018
34
Contemporary update of overall prognosis and nomogram to predict individualized survival for Chinese patients with eyelid sebaceous carcinoma. ( 30236450 )
2018
35
A Case Report of Recurrent Metastatic Sebaceous Carcinoma Which Showed Favorable Response Tt Non-Fluorouracil Based Chemotherapy. ( 30291222 )
2018
36
Merkel cells in extraocular sebaceous carcinoma. ( 30362151 )
2018
37
Impact of clinicopathologic factors on survival in patients with sebaceous carcinoma of the eyelid - a population-based analysis. ( 30373440 )
2018
38
Distinct biological types of ocular adnexal sebaceous carcinoma: HPV-driven and virus-negative tumors arise through non-overlapping molecular-genetic alterations. ( 30420449 )
2018
39
Periocular Sebaceous Carcinoma With Apocrine Differentiation: A Case Report and Review of the Literature. ( 30522363 )
2018
40
Primary sebaceous carcinoma of lacrimal gland: A case report and review of literature. ( 30613681 )
2018
41
Demonstration of a Borst-Jadassohn-Like Phenomenon in Sebaceous Carcinoma of the Eyelid. ( 26020718 )
2017
42
An Analysis of Conjunctival Map Biopsies in Sebaceous Carcinoma. ( 26836812 )
2017
43
Multifocal sebaceous carcinoma of the vulva. ( 28164889 )
2017
44
Sebaceous Carcinoma Treated With Mohs Micrographic Surgery. ( 28165350 )
2017
45
Sebaceous carcinoma in solid organ transplant recipients. ( 28181233 )
2017
46
Sebaceous Carcinoma Arising Within a Nevus Sebaceus Excised by Mohs Micrographic Surgery. ( 28221180 )
2017
47
Sebaceous carcinoma of the breast: a case report. ( 28233285 )
2017
48
Squared-Off Nuclei and "Appliqué" Pattern as a Histopathological Clue to Periocular Sebaceous Carcinoma: A Clinicopathological Study of 50 Neoplasms From 46 Patients. ( 28323778 )
2017
49
Sebaceous carcinoma on the arm of a 10-year-old girl. ( 28633738 )
2017
50
Sebaceous Carcinoma: Clinicopathologic Analysis of 29 Cases in a Tertiary Hospital in Korea. ( 28665073 )
2017

Variations for Sebaceous Adenocarcinoma

Expression for Sebaceous Adenocarcinoma

Search GEO for disease gene expression data for Sebaceous Adenocarcinoma.

Pathways for Sebaceous Adenocarcinoma

Pathways related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 MLH1 MSH2 MSH6 PMS2
2
Show member pathways
12.48 AR MLH1 MSH2 MSH6
3 12.39 AR MLH1 MSH2 MSH6
4 12.17 MLH1 MSH2 MSH6
5 11.8 MLH1 MSH2 MSH6
6 11.69 AR MSH2 MSH6
7 11.55 MLH1 MSH2 PMS2
8 11.23 MLH1 MSH2 MSH6
9 11.2 MLH1 MSH2 MSH6
10 11.17 MSH2 MSH6
11
Show member pathways
11.14 MLH1 MSH2
12
Show member pathways
11.08 MLH1 MSH2
13
Show member pathways
11.01 MLH1 MSH2 MSH6 PMS1 PMS2
14 10.72 MLH1 MSH2 MSH6 PMS2

GO Terms for Sebaceous Adenocarcinoma

Cellular components related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.86 AR KRT5 MLH1 MSH2 MSH6 PLIN2
2 MutSalpha complex GO:0032301 9.16 MSH2 MSH6
3 MutLalpha complex GO:0032389 9.13 MLH1 PMS1 PMS2
4 mismatch repair complex GO:0032300 9.02 MLH1 MSH2 MSH6 PMS1 PMS2

Biological processes related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.8 MLH1 MSH2 MSH6 PMS1 PMS2
2 response to drug GO:0042493 9.76 PLIN2 PMS1 PMS2
3 DNA repair GO:0006281 9.72 MLH1 MSH2 MSH6 PMS1 PMS2
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.61 MLH1 MSH2 MSH6
5 negative regulation of DNA recombination GO:0045910 9.57 MSH2 MSH6
6 determination of adult lifespan GO:0008340 9.56 MSH2 MSH6
7 positive regulation of isotype switching to IgG isotypes GO:0048304 9.55 MLH1 MSH2
8 positive regulation of helicase activity GO:0051096 9.54 MSH2 MSH6
9 maintenance of DNA repeat elements GO:0043570 9.49 MSH2 MSH6
10 positive regulation of isotype switching to IgA isotypes GO:0048298 9.48 MLH1 MSH2
11 isotype switching GO:0045190 9.43 MLH1 MSH2 MSH6
12 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.37 MLH1 MSH2
13 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MLH1 MSH2 MSH6
14 interstrand cross-link repair GO:0036297 9.27 MSH6
15 somatic hypermutation of immunoglobulin genes GO:0016446 9.26 MLH1 MSH2 MSH6 PMS2
16 pyrimidine dimer repair GO:0006290 9.22 MSH6
17 replication fork arrest GO:0043111 9.21 MSH6
18 meiotic mismatch repair GO:0000710 9.16 MSH6
19 mismatch repair GO:0006298 9.02 MLH1 MSH2 MSH6 PMS1 PMS2

Molecular functions related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.92 MLH1 MSH2 MSH6 PMS1 PMS2
2 chromatin binding GO:0003682 9.8 AR MLH1 MSH2 MSH6
3 enzyme binding GO:0019899 9.72 AR MLH1 MSH2 MSH6 PMS1
4 damaged DNA binding GO:0003684 9.56 MSH2 MSH6
5 DNA-dependent ATPase activity GO:0008094 9.55 MSH2 MSH6
6 ATPase activity GO:0016887 9.55 MLH1 MSH2 MSH6 PMS1 PMS2
7 ADP binding GO:0043531 9.54 MSH2 MSH6
8 four-way junction DNA binding GO:0000400 9.51 MSH2 MSH6
9 MutLalpha complex binding GO:0032405 9.48 MSH2 MSH6
10 MutSalpha complex binding GO:0032407 9.46 MLH1 PMS2
11 oxidized purine DNA binding GO:0032357 9.43 MSH2 MSH6
12 single-stranded DNA binding GO:0003697 9.43 MLH1 MSH2 PMS2
13 single thymine insertion binding GO:0032143 9.4 MSH2 MSH6
14 single guanine insertion binding GO:0032142 9.37 MSH2 MSH6
15 guanine/thymine mispair binding GO:0032137 9.13 MLH1 MSH2 MSH6
16 mismatched DNA binding GO:0030983 9.02 MLH1 MSH2 MSH6 PMS1 PMS2

Sources for Sebaceous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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