MCID: SBC011
MIFTS: 42

Sebaceous Adenocarcinoma

Categories: Cancer diseases, Skin diseases, Endocrine diseases

Aliases & Classifications for Sebaceous Adenocarcinoma

MalaCards integrated aliases for Sebaceous Adenocarcinoma:

Name: Sebaceous Adenocarcinoma 12 15 73
Sebaceous Gland Neoplasms 44 73
Sebaceous Gland Neoplasm 12 15
Sebaceous Carcinoma 12 15
Adenocarcinoma of the Sebaceous Gland 12
Malignant Neoplasm of Sebaceous Gland 12
Malignant Sebaceous Neoplasm 73
Malignant Sebaceous Tumor 12
Sebaceous Gland Carcinoma 29
Adenocarcinoma, Sebaceous 44
Sebaceous Neoplasm 12

Classifications:



Summaries for Sebaceous Adenocarcinoma

MalaCards based summary : Sebaceous Adenocarcinoma, also known as sebaceous gland neoplasms, is related to colorectal adenocarcinoma and muir-torre syndrome. An important gene associated with Sebaceous Adenocarcinoma is MLH1 (MutL Homolog 1), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Endometrial cancer. The drugs nivolumab and Technetium Tc 99m Sulfur Colloid have been mentioned in the context of this disorder. Affiliated tissues include skin and lymph node, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

Related Diseases for Sebaceous Adenocarcinoma

Diseases related to Sebaceous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 colorectal adenocarcinoma 29.8 MLH1 MSH2 MSH6
2 muir-torre syndrome 28.1 MLH1 MSH2 MSH6 PMS1 PMS2
3 vulvar sebaceous carcinoma 12.0
4 lower lip cancer 10.6 MLH1 MSH2
5 anal fistula 10.6 MLH1 MSH2
6 melanocytic nevus syndrome, congenital 10.5 MLH1 MSH2
7 childhood kidney cell carcinoma 10.5 MLH1 MSH2
8 attenuated familial adenomatous polyposis 10.5 MSH2 MSH6
9 gastric leiomyoma 10.5 MLH1 MSH6
10 small intestine cancer 10.4 MLH1 MSH2
11 keratoacanthoma 10.4 MLH1 MSH2
12 atypical polypoid adenomyoma 10.4 MLH1 PMS1
13 legius syndrome 10.3 MSH2 MSH6
14 intestinal benign neoplasm 10.3 MLH1 MSH2
15 adenocarcinoma 10.3
16 meibomian cyst 10.3 AR PLIN2
17 familial colorectal cancer 10.2 MLH1 MSH2
18 colorectal adenoma 10.1 MLH1 MSH2
19 familial adenomatous polyposis 10.1 MLH1 MSH2 MSH6
20 lipid-rich carcinoma 10.1 KRT5 PLIN2
21 hereditary breast ovarian cancer syndrome 10.0 MLH1 MSH2 PMS1
22 apocrine adenocarcinoma 10.0 AR KRT5
23 cystitis cystica 9.9 AR KRT5
24 rhabdomyosarcoma 9.9 MSH2 MSH6 PMS2
25 sweat gland cancer 9.8 AR KRT5
26 squamous cell carcinoma 9.7
27 adenosquamous carcinoma 9.7 AR KRT5
28 large cell acanthoma 9.6 KRT5 PTGER4
29 appendix carcinoid tumor 9.6 MLH1 MSH2 MSH6 PMS2
30 adenosquamous colon carcinoma 9.6 MLH1 MSH2 MSH6 PMS2
31 sebaceous adenoma 9.6 MLH1 MSH2 MSH6 PMS2
32 peritoneum cancer 9.6 KRT5 PTGER4
33 female reproductive organ cancer 9.6 MLH1 MSH2 MSH6 PMS2
34 autosomal dominant disease 9.6 MLH1 MSH2 MSH6 PMS2
35 gastrointestinal system cancer 9.6 MLH1 MSH2 MSH6 PMS2
36 neurofibromatosis, type iv, of riccardi 9.6 MSH6 PMS2
37 cecum adenocarcinoma 9.5 MLH1 MSH2 MSH6 PMS1
38 ductal carcinoma in situ 9.5 AR KRT5
39 skin benign neoplasm 9.4 KRT5 MLH1 MSH2 MSH6
40 lynch syndrome i 9.0 MLH1 MSH2 MSH6 PMS1 PMS2
41 mismatch repair cancer syndrome 9.0 MLH1 MSH2 MSH6 PMS1 PMS2
42 autosomal genetic disease 9.0 MLH1 MSH2 MSH6 PMS1 PMS2
43 lynch syndrome 9.0 MLH1 MSH2 MSH6 PMS1 PMS2
44 endometrial cancer 9.0 AR MLH1 MSH2 MSH6 PMS2
45 colorectal cancer 7.8 MLH1 MSH2 MSH6 PMS1 PMS2 PTGER4

Graphical network of the top 20 diseases related to Sebaceous Adenocarcinoma:



Diseases related to Sebaceous Adenocarcinoma

Symptoms & Phenotypes for Sebaceous Adenocarcinoma

GenomeRNAi Phenotypes related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 MLH1 MSH2 MSH6 PMS1 PMS2

MGI Mouse Phenotypes related to Sebaceous Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 PMS2 PTGER4 AR MLH1 MSH2 MSH6
2 digestive/alimentary MP:0005381 9.72 AR KRT5 MLH1 MSH2 PMS2
3 integument MP:0010771 9.7 AR PTGER4 KRT5 MLH1 MSH2 MSH6
4 mortality/aging MP:0010768 9.5 PMS2 PTGER4 AR KRT5 MLH1 MSH2
5 neoplasm MP:0002006 9.17 AR PTGER4 MLH1 MSH2 MSH6 PMS1

Drugs & Therapeutics for Sebaceous Adenocarcinoma

Drugs for Sebaceous Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Technetium Tc 99m Sulfur Colloid Phase 2
3 Anesthetics Phase 2
4 Antibodies Phase 2
5 Immunoglobulins Phase 2
6 Antibodies, Monoclonal Phase 2
7 Radiopharmaceuticals Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sentinel Lymph Node (SLN) Biopsy for Sebaceous Gland Carcinoma of Eyelid Recruiting NCT00832429 Phase 2 Tc99m-Sulfur colloid
2 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Sebaceous Adenocarcinoma

Cochrane evidence based reviews: sebaceous gland neoplasms

Genetic Tests for Sebaceous Adenocarcinoma

Genetic tests related to Sebaceous Adenocarcinoma:

# Genetic test Affiliating Genes
1 Sebaceous Gland Carcinoma 29

Anatomical Context for Sebaceous Adenocarcinoma

MalaCards organs/tissues related to Sebaceous Adenocarcinoma:

41
Skin, Lymph Node

Publications for Sebaceous Adenocarcinoma

Articles related to Sebaceous Adenocarcinoma:

(show all 13)
# Title Authors Year
1
Muir-Torre Syndrome Presenting as Sebaceous Adenocarcinoma and Invasive MSH6-Positive Colorectal Adenocarcinoma. ( 26933426 )
2016
2
Value of (18)F-FDG-PET/CT in ocular sebaceous adenocarcinoma: a case report and literature review. ( 26770604 )
2015
3
Extra ocular sebaceous adenocarcinoma in HIV-positive patient - case report. ( 24346870 )
2013
4
Sebaceous adenocarcinoma of the eyelid. ( 20348857 )
2009
5
Sebaceous adenocarcinoma of the external auditory canal in a New Zealand white rabbit. ( 12443739 )
2002
6
Sebaceous adenocarcinoma of meibomian gland origin with targetoid intra-nuclear inclusions. ( 3586683 )
1987
7
Sebaceous adenocarcinoma of the eyelid. ( 6657173 )
1983
8
Sebaceous adenocarcinoma. ( 7309940 )
1981
9
Sebaceous adenocarcinoma of the eyelid. ( 756324 )
1978
10
Sebaceous adenocarcinoma of the eyelid. Definition of surgical margins. ( 588115 )
1977
11
Cosmetic removal of a sebaceous adenocarcinoma of the eyelid. ( 1041667 )
1975
12
Multicentric sebaceous adenocarcinoma of the meibomian gland. ( 4813308 )
1974
13
Sebaceous adenocarcinoma of the meibomian gland. Presentation of a case and review of the literature. ( 5791504 )
1969

Variations for Sebaceous Adenocarcinoma

Expression for Sebaceous Adenocarcinoma

Search GEO for disease gene expression data for Sebaceous Adenocarcinoma.

Pathways for Sebaceous Adenocarcinoma

Pathways related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 MLH1 MSH2 MSH6 PMS2
2
Show member pathways
12.48 AR MLH1 MSH2 MSH6
3 12.38 AR MLH1 MSH2 MSH6 PTGER4
4 12.16 MLH1 MSH2 MSH6
5 11.77 AR MSH2 MSH6
6 11.67 MLH1 MSH2 MSH6 PTGER4
7 11.66 MLH1 MSH2 PMS2
8 11.36 MLH1 MSH2 MSH6
9 11.16 MSH2 MSH6
10
Show member pathways
11.12 MLH1 MSH2
11
Show member pathways
11.06 MLH1 MSH2
12
Show member pathways
11.01 MLH1 MSH2 MSH6 PMS1 PMS2
13 10.72 MLH1 MSH2 MSH6 PMS2

GO Terms for Sebaceous Adenocarcinoma

Cellular components related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.86 AR KRT5 MLH1 MSH2 MSH6 PLIN2
2 MutSalpha complex GO:0032301 9.16 MSH2 MSH6
3 MutLalpha complex GO:0032389 9.13 MLH1 PMS1 PMS2
4 mismatch repair complex GO:0032300 9.02 MLH1 MSH2 MSH6 PMS1 PMS2

Biological processes related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.8 MLH1 MSH2 MSH6 PMS1 PMS2
2 response to drug GO:0042493 9.73 PLIN2 PMS1 PMS2
3 DNA repair GO:0006281 9.72 MLH1 MSH2 MSH6 PMS1 PMS2
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.61 MLH1 MSH2 MSH6
5 determination of adult lifespan GO:0008340 9.55 MSH2 MSH6
6 positive regulation of isotype switching to IgG isotypes GO:0048304 9.54 MLH1 MSH2
7 positive regulation of helicase activity GO:0051096 9.52 MSH2 MSH6
8 negative regulation of DNA recombination GO:0045910 9.51 MSH2 MSH6
9 maintenance of DNA repeat elements GO:0043570 9.49 MSH2 MSH6
10 positive regulation of isotype switching to IgA isotypes GO:0048298 9.48 MLH1 MSH2
11 meiotic mismatch repair GO:0000710 9.46 MSH2 MSH6
12 isotype switching GO:0045190 9.43 MLH1 MSH2 MSH6
13 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.37 MLH1 MSH2
14 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MLH1 MSH2 MSH6
15 somatic hypermutation of immunoglobulin genes GO:0016446 9.26 MLH1 MSH2 MSH6 PMS2
16 mismatch repair GO:0006298 9.02 MLH1 MSH2 MSH6 PMS1 PMS2

Molecular functions related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.92 MLH1 MSH2 MSH6 PMS1 PMS2
2 ATPase activity GO:0016887 9.65 MLH1 MSH2 MSH6 PMS1 PMS2
3 single-stranded DNA binding GO:0003697 9.62 MLH1 MSH2 PMS1 PMS2
4 damaged DNA binding GO:0003684 9.55 MSH2 MSH6
5 DNA-dependent ATPase activity GO:0008094 9.54 MSH2 MSH6
6 ADP binding GO:0043531 9.51 MSH2 MSH6
7 four-way junction DNA binding GO:0000400 9.49 MSH2 MSH6
8 oxidized purine DNA binding GO:0032357 9.48 MSH2 MSH6
9 MutLalpha complex binding GO:0032405 9.46 MSH2 MSH6
10 MutSalpha complex binding GO:0032407 9.43 MLH1 PMS2
11 single guanine insertion binding GO:0032142 9.4 MSH2 MSH6
12 single thymine insertion binding GO:0032143 9.37 MSH2 MSH6
13 guanine/thymine mispair binding GO:0032137 9.33 MLH1 MSH2 MSH6
14 single base insertion or deletion binding GO:0032138 9.13 MSH2 MSH6 PMS2
15 mismatched DNA binding GO:0030983 9.02 MLH1 MSH2 MSH6 PMS1 PMS2

Sources for Sebaceous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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