MCID: SBC011
MIFTS: 48

Sebaceous Adenocarcinoma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Sebaceous Adenocarcinoma

MalaCards integrated aliases for Sebaceous Adenocarcinoma:

Name: Sebaceous Adenocarcinoma 12 15 73
Sebaceous Gland Neoplasms 44 73
Sebaceous Gland Neoplasm 12 15
Sebaceous Carcinoma 12 15
Adenocarcinoma of the Sebaceous Gland 12
Malignant Neoplasm of Sebaceous Gland 12
Malignant Sebaceous Neoplasm 73
Malignant Sebaceous Tumor 12
Sebaceous Gland Carcinoma 29
Adenocarcinoma, Sebaceous 44
Sebaceous Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4839 DOID:4840 DOID:5759
SNOMED-CT 68 54734006
ICD10 33 C44

Summaries for Sebaceous Adenocarcinoma

MalaCards based summary : Sebaceous Adenocarcinoma, also known as sebaceous gland neoplasms, is related to meibomian cyst and colorectal adenocarcinoma. An important gene associated with Sebaceous Adenocarcinoma is MLH1 (MutL Homolog 1), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Endometrial cancer. The drugs Nivolumab and Radiopharmaceuticals have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and kidney, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

Related Diseases for Sebaceous Adenocarcinoma

Diseases related to Sebaceous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 meibomian cyst 30.0 AR PLIN2
2 colorectal adenocarcinoma 29.8 MLH1 MSH2 MSH6
3 sebaceous adenoma 29.7 MLH1 MSH2 MSH6 PMS2
4 lynch syndrome 29.7 MLH1 MSH2 MSH6 PMS1 PMS2
5 mismatch repair cancer syndrome 29.2 MLH1 MSH2 MSH6 PMS1 PMS2
6 muir-torre syndrome 29.1 MLH1 MSH2 MSH6 PLIN2 PMS1 PMS2
7 vulvar sebaceous carcinoma 12.2
8 eyelid carcinoma 10.6
9 adenocarcinoma 10.4
10 teratoma 10.2
11 colorectal cancer, hereditary nonpolyposis, type 7 10.2 MLH1 MSH2
12 keratosis 10.2
13 cystic teratoma 10.2
14 in situ carcinoma 10.2
15 lower lip cancer 10.2 MLH1 MSH2
16 anal fistula 10.2 MLH1 MSH2
17 colorectal cancer 5 10.2 MLH1 MSH6
18 melanocytic nevus syndrome, congenital 10.2 MLH1 MSH2
19 spindle cell intraocular melanoma 10.1 MLH1 PMS2
20 gastric leiomyoma 10.1 MLH1 MSH6
21 childhood kidney cell carcinoma 10.1 MLH1 MSH2
22 squamous cell carcinoma 10.1
23 attenuated familial adenomatous polyposis 10.1 MSH2 MSH6
24 intestinal benign neoplasm 10.1 MLH1 MSH2
25 keratoacanthoma 10.1 MLH1 MSH2
26 legius syndrome 10.1 MSH2 MSH6
27 basal cell carcinoma 1 10.1
28 basal cell carcinoma 10.1
29 actinic keratosis 10.1
30 bowen's disease 10.1
31 papilloma 10.1
32 bilateral retinoblastoma 10.1
33 familial colorectal cancer 10.1 MLH1 MSH2
34 colorectal adenoma 10.1 MLH1 MSH2
35 lipid-rich carcinoma 10.0 KRT5 PLIN2
36 colorectal cancer, hereditary nonpolyposis, type 5 10.0 MLH1 MSH2 MSH6
37 female reproductive system disease 10.0 MLH1 MSH2 MSH6
38 adenoma 10.0
39 familial adenomatous polyposis 10.0 MLH1 MSH2 MSH6
40 colorectal cancer, hereditary nonpolyposis, type 4 10.0 MLH1 MSH2 PMS2
41 apocrine adenocarcinoma 10.0 AR KRT5
42 sebaceous gland disease 10.0 AR MSH2 PLIN2
43 neurofibromatosis, type iv, of riccardi 10.0 MSH6 PMS2
44 cystitis cystica 10.0 AR KRT5
45 rhabdomyosarcoma 9.9 MSH2 MSH6 PMS2
46 lymphoma, hodgkin, classic 9.9
47 lymphoma, non-hodgkin, familial 9.9
48 malignant fibroxanthoma 9.9
49 histiocytoma 9.9
50 fibrous histiocytoma 9.9

Graphical network of the top 20 diseases related to Sebaceous Adenocarcinoma:



Diseases related to Sebaceous Adenocarcinoma

Symptoms & Phenotypes for Sebaceous Adenocarcinoma

GenomeRNAi Phenotypes related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 MLH1 MSH2 MSH6 PMS1 PMS2

MGI Mouse Phenotypes related to Sebaceous Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.87 AR MLH1 MSH2 MSH6 PLIN2 PMS2
2 immune system MP:0005387 9.8 AR MLH1 MSH2 MSH6 PLIN2 PMS2
3 digestive/alimentary MP:0005381 9.77 AR KRT5 MLH1 MSH2 PMS2
4 integument MP:0010771 9.7 AR KRT5 MLH1 MSH2 MSH6 PLIN2
5 mortality/aging MP:0010768 9.5 AR KRT5 MLH1 MSH2 MSH6 PMS2
6 neoplasm MP:0002006 9.17 AR MLH1 MSH2 MSH6 PMS1 PMS2

Drugs & Therapeutics for Sebaceous Adenocarcinoma

Drugs for Sebaceous Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nivolumab Approved Phase 2 946414-94-4
2 Radiopharmaceuticals Phase 2
3 Anesthetics Phase 2
4 Technetium Tc 99m Sulfur Colloid Phase 2
5 Antibodies, Monoclonal Phase 2
6 Antibodies Phase 2
7 Immunoglobulins Phase 2
8 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sentinel Lymph Node (SLN) Biopsy for Sebaceous Gland Carcinoma of Eyelid Recruiting NCT00832429 Phase 2 Tc99m-Sulfur colloid
2 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Sebaceous Adenocarcinoma

Cochrane evidence based reviews: sebaceous gland neoplasms

Genetic Tests for Sebaceous Adenocarcinoma

Genetic tests related to Sebaceous Adenocarcinoma:

# Genetic test Affiliating Genes
1 Sebaceous Gland Carcinoma 29

Anatomical Context for Sebaceous Adenocarcinoma

MalaCards organs/tissues related to Sebaceous Adenocarcinoma:

41
Skin, Lymph Node, Kidney, Colon, Thyroid, Small Intestine, Appendix

Publications for Sebaceous Adenocarcinoma

Articles related to Sebaceous Adenocarcinoma:

(show top 50) (show all 354)
# Title Authors Year
1
Clinicopathological characteristics of breast sebaceous adenocarcinoma. ( 30509049 )
2018
2
Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation. ( 30225334 )
2018
3
Utility of topical epinephrine for determining the resection range of eyelid sebaceous carcinoma with dermatitis. ( 29788677 )
2018
4
Sebaceous carcinoma of the breast in a patient with a pathogenic BRCA2 (886delGT) mutation - focus on histopathologic and immunohistochemical features. ( 29575201 )
2018
5
Intraoperative Adjunctive Mitomycin C and Cryotherapy for Recurrent Conjunctival Papillary Sebaceous Carcinoma. ( 29681840 )
2018
6
Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma. ( 29760388 )
2018
7
Eyelid sebaceous carcinoma in situ presenting as haemorrhagic cyst. ( 29797387 )
2018
8
Programmed death receptor Ligand 1 expression in eyelid sebaceous carcinoma: a consecutive case series of 41 patients. ( 29862664 )
2018
9
Near complete response to Pembrolizumab in microsatellite-stable metastatic sebaceous carcinoma. ( 29914578 )
2018
10
Carboplatin and Pembrolizumab Chemoimmunotherapy Achieves Remission in Recurrent, Metastatic Sebaceous Carcinoma. ( 29979269 )
2018
11
Updates on the clinical diagnosis and management of ocular sebaceous carcinoma: a brief review of the literature. ( 29983580 )
2018
12
Sebaceous Carcinoma in Situ Masquerading Clinically and Histologically as Paget Disease of the Breast. ( 30110525 )
2018
13
Intraoral Sebaceous Carcinoma: Case Report of a Rare Tumor Emphasizing the Histopathological Differential Diagnosis. ( 30116646 )
2018
14
Comparison of posterior lamellar resection versus lumpectomy for initial management of localized tarsal conjunctival sebaceous carcinoma in 54 cases. ( 30127144 )
2018
15
Prognostic factors for local recurrence, metastasis and survival for sebaceous carcinoma of the eyelid: observations in 100 patients. ( 30131380 )
2018
16
The Usefulness of Dermoscopy in Extraocular Sebaceous Carcinoma. ( 30210176 )
2018
17
High expression of PD-1 and PD-L1 in ocular adnexal sebaceous carcinoma. ( 30228943 )
2018
18
Contemporary update of overall prognosis and nomogram to predict individualized survival for Chinese patients with eyelid sebaceous carcinoma. ( 30236450 )
2018
19
A Case Report of Recurrent Metastatic Sebaceous Carcinoma Which Showed Favorable Response Tt Non-Fluorouracil Based Chemotherapy. ( 30291222 )
2018
20
Merkel cells in extraocular sebaceous carcinoma. ( 30362151 )
2018
21
Impact of clinicopathologic factors on survival in patients with sebaceous carcinoma of the eyelid - a population-based analysis. ( 30373440 )
2018
22
Distinct biological types of ocular adnexal sebaceous carcinoma: HPV-driven and virus-negative tumors arise through non-overlapping molecular-genetic alterations. ( 30420449 )
2018
23
Periocular Sebaceous Carcinoma With Apocrine Differentiation: A Case Report and Review of the Literature. ( 30522363 )
2018
24
Immunohistochemical markers informing the diagnosis of sebaceous carcinoma and its distinction from its mimics: Adipophilin and factor XIIIa to the rescue? ( 29087003 )
2018
25
Dermoscopic features distinctive for extraocular sebaceous carcinoma. ( 29235655 )
2018
26
Extraocular sebaceous carcinoma accompanied by invasive squamous cell carcinoma: The first case report and consideration of histogenesis. ( 29266386 )
2018
27
Sebaceous carcinoma mimicking a chalazion in a young patient. ( 29287845 )
2018
28
Analysis of hedgehog signaling in periocular sebaceous carcinoma. ( 29423837 )
2018
29
Sebaceous carcinoma of the breast: Histological, cytological, and ultrastructural features. ( 29498454 )
2018
30
Breast sebaceous carcinoma-a rare entity. Clinico-pathological description of two cases and brief review. ( 29556777 )
2018
31
Demonstration of a Borst-Jadassohn-Like Phenomenon in Sebaceous Carcinoma of the Eyelid. ( 26020718 )
2017
32
An Analysis of Conjunctival Map Biopsies in Sebaceous Carcinoma. ( 26836812 )
2017
33
Multifocal sebaceous carcinoma of the vulva. ( 28164889 )
2017
34
Sebaceous Carcinoma Treated With Mohs Micrographic Surgery. ( 28165350 )
2017
35
Sebaceous carcinoma in solid organ transplant recipients. ( 28181233 )
2017
36
Sebaceous Carcinoma Arising Within a Nevus Sebaceus Excised by Mohs Micrographic Surgery. ( 28221180 )
2017
37
Sebaceous carcinoma of the breast: a case report. ( 28233285 )
2017
38
Squared-Off Nuclei and "Appliqué" Pattern as a Histopathological Clue to Periocular Sebaceous Carcinoma: A Clinicopathological Study of 50 Neoplasms From 46 Patients. ( 28323778 )
2017
39
Sebaceous carcinoma on the arm of a 10-year-old girl. ( 28633738 )
2017
40
Sebaceous Carcinoma: Clinicopathologic Analysis of 29 Cases in a Tertiary Hospital in Korea. ( 28665073 )
2017
41
Sebaceous Carcinoma: A Review of the Scientific Literature. ( 28681210 )
2017
42
Sebaceous carcinoma in situ as a concept and diagnostic entity. ( 29034129 )
2017
43
Muir-Torre Syndrome Presenting as Sebaceous Adenocarcinoma and Invasive MSH6-Positive Colorectal Adenocarcinoma. ( 26933426 )
2016
44
Effect of Non-Hodgkin Lymphoma on Survival in Patients With Malignant Fibrous Histiocytoma, Kaposi Sarcoma, and Sebaceous Carcinoma: A SEER Population-Based Study. ( 26730972 )
2016
45
Palliative 5-fluorouracil and cisplatin chemotherapy in recurrent metastatic sebaceous carcinoma: Case report and literature review. ( 23981285 )
2016
46
Intraoral sebaceous carcinoma metastatic to the lung and subcutis: Case report and discussion of the literature. ( 25899035 )
2016
47
Recurrent sebaceous carcinoma of the eyelid: Outcome after postoperative reirradiation. ( 25900883 )
2016
48
Sebaceous carcinoma within rippled/carcinoid pattern sebaceoma. ( 26268140 )
2016
49
Kissing tumors of sebaceous carcinoma on the eyelids in collision with melanocytic nevus: A case report. ( 26661447 )
2016
50
Management Considerations in Extraocular Sebaceous Carcinoma. ( 26730975 )
2016

Variations for Sebaceous Adenocarcinoma

Expression for Sebaceous Adenocarcinoma

Search GEO for disease gene expression data for Sebaceous Adenocarcinoma.

Pathways for Sebaceous Adenocarcinoma

Pathways related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 MLH1 MSH2 MSH6 PMS2
2
Show member pathways
12.48 AR MLH1 MSH2 MSH6
3 12.38 AR MLH1 MSH2 MSH6 PTGER4
4 12.17 MLH1 MSH2 MSH6
5 11.77 AR MSH2 MSH6
6 11.67 MLH1 MSH2 MSH6 PTGER4
7 11.66 MLH1 MSH2 PMS2
8 11.36 MLH1 MSH2 MSH6
9 11.23 MLH1 MSH2 MSH6
10 11.17 MSH2 MSH6
11
Show member pathways
11.14 MLH1 MSH2
12
Show member pathways
11.08 MLH1 MSH2
13
Show member pathways
11.01 MLH1 MSH2 MSH6 PMS1 PMS2
14 10.72 MLH1 MSH2 MSH6 PMS2

GO Terms for Sebaceous Adenocarcinoma

Cellular components related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.86 AR KRT5 MLH1 MSH2 MSH6 PLIN2
2 MutSalpha complex GO:0032301 9.16 MSH2 MSH6
3 MutLalpha complex GO:0032389 9.13 MLH1 PMS1 PMS2
4 mismatch repair complex GO:0032300 9.02 MLH1 MSH2 MSH6 PMS1 PMS2

Biological processes related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.8 MLH1 MSH2 MSH6 PMS1 PMS2
2 response to drug GO:0042493 9.76 PLIN2 PMS1 PMS2
3 DNA repair GO:0006281 9.72 MLH1 MSH2 MSH6 PMS1 PMS2
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.61 MLH1 MSH2 MSH6
5 interstrand cross-link repair GO:0036297 9.58 MSH2 MSH6
6 negative regulation of DNA recombination GO:0045910 9.57 MSH2 MSH6
7 determination of adult lifespan GO:0008340 9.56 MSH2 MSH6
8 positive regulation of isotype switching to IgG isotypes GO:0048304 9.55 MLH1 MSH2
9 positive regulation of helicase activity GO:0051096 9.54 MSH2 MSH6
10 pyrimidine dimer repair GO:0006290 9.52 MSH2 MSH6
11 replication fork arrest GO:0043111 9.51 MSH2 MSH6
12 maintenance of DNA repeat elements GO:0043570 9.49 MSH2 MSH6
13 positive regulation of isotype switching to IgA isotypes GO:0048298 9.48 MLH1 MSH2
14 meiotic mismatch repair GO:0000710 9.46 MSH2 MSH6
15 isotype switching GO:0045190 9.43 MLH1 MSH2 MSH6
16 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.37 MLH1 MSH2
17 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MLH1 MSH2 MSH6
18 somatic hypermutation of immunoglobulin genes GO:0016446 9.26 MLH1 MSH2 MSH6 PMS2
19 mismatch repair GO:0006298 9.02 MLH1 MSH2 MSH6 PMS1 PMS2

Molecular functions related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.92 MLH1 MSH2 MSH6 PMS1 PMS2
2 chromatin binding GO:0003682 9.8 AR MLH1 MSH2 MSH6
3 enzyme binding GO:0019899 9.72 AR MLH1 MSH2 MSH6 PMS1
4 damaged DNA binding GO:0003684 9.56 MSH2 MSH6
5 single-stranded DNA binding GO:0003697 9.56 MLH1 MSH2 PMS1 PMS2
6 DNA-dependent ATPase activity GO:0008094 9.55 MSH2 MSH6
7 ATPase activity GO:0016887 9.55 MLH1 MSH2 MSH6 PMS1 PMS2
8 ADP binding GO:0043531 9.54 MSH2 MSH6
9 four-way junction DNA binding GO:0000400 9.51 MSH2 MSH6
10 MutLalpha complex binding GO:0032405 9.48 MSH2 MSH6
11 MutSalpha complex binding GO:0032407 9.46 MLH1 PMS2
12 oxidized purine DNA binding GO:0032357 9.43 MSH2 MSH6
13 single thymine insertion binding GO:0032143 9.4 MSH2 MSH6
14 single guanine insertion binding GO:0032142 9.37 MSH2 MSH6
15 guanine/thymine mispair binding GO:0032137 9.13 MLH1 MSH2 MSH6
16 mismatched DNA binding GO:0030983 9.02 MLH1 MSH2 MSH6 PMS1 PMS2

Sources for Sebaceous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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