MCID: SBC011
MIFTS: 42

Sebaceous Adenocarcinoma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Sebaceous Adenocarcinoma

MalaCards integrated aliases for Sebaceous Adenocarcinoma:

Name: Sebaceous Adenocarcinoma 12 15 17 71
Sebaceous Carcinoma 12 15
Adenocarcinoma of the Sebaceous Gland 12
Malignant Neoplasm of Sebaceous Gland 12
Malignant Sebaceous Neoplasm 71
Malignant Sebaceous Tumor 12
Sebaceous Gland Neoplasms 71
Adenocarcinoma, Sebaceous 43

Classifications:



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Disease Ontology 12 DOID:4839 DOID:4840
MeSH 43 D018266
NCIt 49 C40310 C8409
SNOMED-CT 67 54734006
ICD10 32 C44
UMLS 71 C0036503 C0206684 C1382026

Summaries for Sebaceous Adenocarcinoma

MalaCards based summary : Sebaceous Adenocarcinoma, also known as sebaceous carcinoma, is related to clear cell hidradenoma and hidradenoma. An important gene associated with Sebaceous Adenocarcinoma is MLH1 (MutL Homolog 1), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Anesthetics and Technetium Tc 99m Sulfur Colloid have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and colon, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

Related Diseases for Sebaceous Adenocarcinoma

Diseases related to Sebaceous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 330)
# Related Disease Score Top Affiliating Genes
1 clear cell hidradenoma 30.6 PIP KRT5
2 hidradenoma 30.6 PIP KRT5
3 adenoma 30.4 TP53 MSH6 MSH2 MLH1
4 sebaceous adenoma 30.4 PMS2 PLIN2 MSH6 MSH2 MLH1
5 rectum cancer 30.1 MSH6 MSH2 MLH1
6 adenocarcinoma 30.0 TP53 MSH6 MSH2 MLH1 ERBB2
7 keratosis, seborrheic 29.8 TP53 MLANA KRT5
8 breast squamous cell carcinoma 29.7 TP53 ERBB2
9 eccrine acrospiroma 29.7 TP53 PIP KRT5
10 squamous cell papilloma 29.7 TP53 KRT14
11 mammary paget's disease 29.7 PIP KRT14 ERBB2
12 mismatch repair cancer syndrome 29.6 PMS2 PMS1 MSH6 MSH2 MLH1
13 lynch syndrome 29.5 TP53 PMS2 PMS1 MSH6 MSH2 MLH1
14 pleomorphic adenoma carcinoma 29.4 TP53 ERBB2 AR
15 papilloma 29.3 TP53 KRT5 KRT14
16 basal cell carcinoma 29.3 TP53 MSH2 MLH1 KRT5 KRT14 AR
17 transitional cell carcinoma 29.3 TP53 MSH2 MLH1 ERBB2
18 skin benign neoplasm 29.1 MSH6 MSH2 MLH1 KRT5 KRT14
19 pleomorphic adenoma 28.9 TP53 KRT14 ERBB2 AR
20 in situ carcinoma 28.9 TP53 PIP KRT5 KRT14 ERBB2
21 comedo carcinoma 28.9 TP53 KRT14 ERBB2
22 muir-torre syndrome 28.8 TP53 PMS2 PMS1 PLIN2 MSH6 MSH2
23 paget disease, extramammary 28.8 PIP MLANA KRT5 ERBB2 AR
24 colorectal adenocarcinoma 28.7 TP53 PMS2 MSH6 MSH2 MLH1 ERBB2
25 lipid-rich carcinoma 28.5 PLIN2 PIP KRT5 KRT14 ERBB2
26 apocrine adenocarcinoma 28.4 PIP KRT5 KRT14 ERBB2 AR
27 mucoepidermoid carcinoma 28.4 TP53 KRT5 KRT14 ERBB2
28 vulvar sebaceous carcinoma 12.5
29 eyelid carcinoma 10.7
30 spindle cell intraocular melanoma 10.5 PMS2 MLH1
31 attenuated familial adenomatous polyposis 10.5 MSH6 MSH2
32 jejunal adenocarcinoma 10.5 MSH6 MLH1
33 ascending colon cancer 10.4 MSH2 MLH1
34 periampullary adenoma 10.4 PMS2 MSH6
35 lower lip cancer 10.4 MSH2 MLH1
36 anal canal paget's disease 10.4 PIP MLANA
37 anal paget's disease 10.4 PIP MLANA
38 anal fistula 10.4 MSH2 MLH1
39 renal pelvis transitional cell carcinoma 10.4 MSH6 MSH2 MLH1
40 ceruminoma 10.3 PIP KRT5
41 cervical adenoma malignum 10.3 MSH6 MSH2 MLH1
42 autosomal dominant non-syndromic intellectual disability 8 10.3 MSH6 MSH2 MLH1
43 mental retardation, autosomal dominant 20 10.3 MSH6 MSH2 MLH1
44 dysplastic nevus syndrome 10.3 MSH6 MSH2 MLH1
45 eccrine papillary adenocarcinoma 10.3 PIP KRT5
46 bartholin's gland adenocarcinoma 10.3 PTGER4 PIP
47 peritoneal serous papillary adenocarcinoma 10.3 PTGER4 PIP
48 vulvar eccrine porocarcinoma 10.3 PTGER4 PIP
49 peritoneal serous adenocarcinoma 10.3 PTGER4 PIP
50 cystic teratoma 10.3

Graphical network of the top 20 diseases related to Sebaceous Adenocarcinoma:



Diseases related to Sebaceous Adenocarcinoma

Symptoms & Phenotypes for Sebaceous Adenocarcinoma

GenomeRNAi Phenotypes related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.1 MLH1 MSH2 MSH6 PMS1 PMS2 TP53

MGI Mouse Phenotypes related to Sebaceous Adenocarcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.16 AR ERBB2 KRT14 MLH1 MSH2 MSH6
2 digestive/alimentary MP:0005381 10.09 AR ERBB2 KRT14 KRT5 MLH1 MSH2
3 hematopoietic system MP:0005397 10.07 AR KRT14 MLH1 MSH2 MSH6 PIP
4 endocrine/exocrine gland MP:0005379 10.06 AR ERBB2 KRT14 MLH1 PIP PLIN2
5 homeostasis/metabolism MP:0005376 10.06 AR ERBB2 KRT14 MLH1 MSH2 MSH6
6 immune system MP:0005387 9.96 AR KRT14 MLH1 MSH2 MSH6 PIP
7 integument MP:0010771 9.9 AR ERBB2 KRT14 KRT5 MLANA MLH1
8 neoplasm MP:0002006 9.65 AR ERBB2 KRT14 MLH1 MSH2 MSH6
9 reproductive system MP:0005389 9.28 AR ERBB2 KRT14 MLH1 PIP PLIN2

Drugs & Therapeutics for Sebaceous Adenocarcinoma

Drugs for Sebaceous Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics Phase 2
2 Technetium Tc 99m Sulfur Colloid Phase 2
3 Radiopharmaceuticals Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sentinel Lymph Node Localization and Biopsy for Sebaceous Gland Carcinoma of the Eyelid Recruiting NCT00832429 Phase 2 Tc99m-Sulfur colloid

Search NIH Clinical Center for Sebaceous Adenocarcinoma

Cochrane evidence based reviews: adenocarcinoma, sebaceous

Genetic Tests for Sebaceous Adenocarcinoma

Anatomical Context for Sebaceous Adenocarcinoma

MalaCards organs/tissues related to Sebaceous Adenocarcinoma:

40
Breast, Skin, Colon, Ovary, Salivary Gland, Eye, Lymph Node

Publications for Sebaceous Adenocarcinoma

Articles related to Sebaceous Adenocarcinoma:

(show top 50) (show all 754)
# Title Authors PMID Year
1
State of the art of Mohs surgery for rare cutaneous tumors in the Spanish Registry of Mohs Surgery (REGESMOHS). 61
31777957 2020
2
Programmed cell death 1 protein and programmed death-ligand 1 inhibitors in the treatment of nonmelanoma skin cancer: A systematic review. 61
31163235 2020
3
[Does orbital exenteration still has a place in 2019?] 61
31831277 2020
4
Orbital exenteration and conjunctival melanoma: a 14-year study at the Jules Gonin Eye Hospital. 61
31959885 2020
5
Concomitant Orbital Tumours: Small Lymphocytic Lymphoma Involving the Lacrimal Gland of a Patient with Clinical Diagnoses of Muir-Torre Syndrome and Extensive Sebaceous Gland Carcinoma of the Ipsilateral Eyelid. 61
32002399 2020
6
Cutaneous sebaceous carcinoma. 61
31956994 2020
7
Sebaceous carcinoma: controversies and their evidence for clinical practice. 61
31471636 2020
8
A rare giant extraocular, anterior chest wall sebaceous carcinoma. 61
31835133 2020
9
Recurrent sebaceous carcinoma on the shoulder. 61
31922644 2020
10
The Programmed Death Pathway in Ocular Adnexal Sebaceous Carcinoma. 61
31593039 2020
11
[Sebaceous carcinoma in situ in extraocular skin : Case report and discussion of the new entity]. 61
31420711 2020
12
Nasal Sebaceous Carcinoma: A Case Report and Review of the Literature. 61
31526773 2020
13
Whole-exome sequencing for ocular adnexal sebaceous carcinoma suggests PCDH15 as a novel mutation associated with metastasis. 61
31937901 2020
14
Angiogenesis in Ocular and Extraocular Sebaceous Carcinoma. 61
31612234 2019
15
Sebaceous carcinoma: evidence-based clinical practice guidelines. 61
31797796 2019
16
Impact of surgery and adjuvant treatment on the outcome of extraocular sebaceous carcinoma: a systematic review and individual patient's data analysis of 206 cases. 61
31850516 2019
17
Update on the Pathology, Genetics and Somatic Landscape of Sebaceous Tumours. 61
31821583 2019
18
Nasolacrimal duct obstruction secondary to lacrimal sac involvement by sebaceous carcinoma. 61
31809621 2019
19
Periocular Sebaceous Carcinoma Masquerading as an Intratarsal Cyst. 61
31770178 2019
20
High-dose-rate interstitial brachytherapy for a bulky sebaceous carcinoma of the eyelid: A case report. 61
31624595 2019
21
Radiotherapy for localized sebaceous carcinoma of the eyelid: a retrospective analysis of 83 patients. 61
31271440 2019
22
[Follow-up of a sebaceous carcinoma of the eyelids: A case report]. 61
31204087 2019
23
Sebaceous carcinoma of the caruncle. 61
31178073 2019
24
Loss of ZNF750 in ocular and cutaneous sebaceous carcinoma. 61
31148199 2019
25
Muir-Torre syndrome: sebaceous carcinoma concurrent with colon cancer in a kidney transplant recipient; a case report. 61
31664942 2019
26
Primary sebaceous carcinoma of the male breast: Case report and review of literature. 61
31595593 2019
27
Periocular intraepithelial sebaceous neoplasia: critical appraisal of nomenclature and prognostic importance. 61
31662439 2019
28
Cytologic Grading of Cutaneous Sebaceous Neoplasms: Does it Help to Differentiate Benign From Malignant? 61
31584883 2019
29
The practice patterns in the management of sebaceous carcinoma of the eyelid in the Asia Pacific region. 61
30952958 2019
30
Predictors of Local Recurrence for Eyelid Sebaceous Carcinoma: Questionable Value of Routine Conjunctival Map Biopsies for Detection of Pagetoid Spread. 61
30865067 2019
31
Utility of Ber-EP4 and MOC-31 in Basaloid Skin Tumor Detection. 61
29629953 2019
32
Comparison of Mohs Surgery and Surgical Excision in the Treatment of Localized Sebaceous Carcinoma. 61
30829780 2019
33
Superficial sebaceous carcinoma: The correlations between the clinical, dermoscopic and histopathological findings of a rare variant of sebaceous carcinoma. 61
30860621 2019
34
Potentially actionable FGFR2 high-level amplification in thymic sebaceous carcinoma. 61
31401665 2019
35
Impact of clinicopathologic factors on survival in patients with sebaceous carcinoma of the eyelid - a population-based analysis. 61
30373440 2019
36
Prognostic factors for local recurrence, metastasis and survival for sebaceous carcinoma of the eyelid: observations in 100 patients. 61
30131380 2019
37
Lacrimal Sac Sebaceous Carcinoma. 61
30921057 2019
38
Re-evaluating the epidemiology of cutaneous sebaceous carcinoma. 61
31328254 2019
39
Muir-Torre syndrome appropriate use criteria: Effect of patient age on appropriate use scores. 61
30895633 2019
40
Regression of Sebaceous Carcinoma of the Eyelid after a Small Incisional Biopsy: Report of Two Cases. 61
31367586 2019
41
Mutations in TP53, ZNF750, and RB1 typify ocular sebaceous carcinoma. 61
31278009 2019
42
Mohs micrographic surgery for eyelid sebaceous carcinoma: A multicenter cohort of 360 patients. 61
30639290 2019
43
Periocular Sebaceous Carcinoma With Apocrine Differentiation: A Case Report and Review of the Literature. 61
30522363 2019
44
Mohs micrographic surgery versus wide local excision for sebaceous adenocarcinoma of the eyelid : Analysis of a national database. 61
30894313 2019
45
Eyelid sebaceous carcinoma: Validation of the 8th edition of the American Joint Committee on cancer T staging system and the prognostic factors for local recurrence, nodal metastasis, and survival. 61
31147618 2019
46
Programmed death receptor Ligand 1 expression in eyelid sebaceous carcinoma: a consecutive case series of 41 patients. 61
29862664 2019
47
Ocular sebaceous gland carcinoma: an update of the literature. 61
29696467 2019
48
Sebaceous carcinoma of the penis: As aggressive as it is rare. 61
31040615 2019
49
Pedunculated poorly differentiated papillary sebaceous carcinoma of the eyelid. 61
31020881 2019
50
[Ⅲ.Topics in Histopathological Diagnosis and Classification of Cutaneous Sebaceous Carcinoma]. 61
31164502 2019

Variations for Sebaceous Adenocarcinoma

Expression for Sebaceous Adenocarcinoma

Search GEO for disease gene expression data for Sebaceous Adenocarcinoma.

Pathways for Sebaceous Adenocarcinoma

GO Terms for Sebaceous Adenocarcinoma

Cellular components related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.07 TP53 SERPINB3 PMS2 PMS1 PLIN2 PIP
2 MutSalpha complex GO:0032301 9.16 MSH6 MSH2
3 MutLalpha complex GO:0032389 9.13 PMS2 PMS1 MLH1
4 mismatch repair complex GO:0032300 9.02 PMS2 PMS1 MSH6 MSH2 MLH1

Biological processes related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.86 TP53 PMS2 PMS1 PLIN2
2 cellular response to DNA damage stimulus GO:0006974 9.85 TP53 PMS2 PMS1 MSH6 MSH2 MLH1
3 DNA repair GO:0006281 9.83 PMS2 PMS1 MSH6 MSH2 MLH1
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.63 MSH6 MSH2 MLH1
5 response to X-ray GO:0010165 9.58 TP53 MSH2
6 negative regulation of DNA recombination GO:0045910 9.57 MSH6 MSH2
7 hemidesmosome assembly GO:0031581 9.55 KRT5 KRT14
8 response to UV-B GO:0010224 9.54 TP53 MSH2
9 positive regulation of isotype switching to IgG isotypes GO:0048304 9.52 MSH2 MLH1
10 positive regulation of helicase activity GO:0051096 9.51 MSH6 MSH2
11 determination of adult lifespan GO:0008340 9.5 TP53 MSH6 MSH2
12 positive regulation of isotype switching to IgA isotypes GO:0048298 9.49 MSH2 MLH1
13 maintenance of DNA repeat elements GO:0043570 9.48 MSH6 MSH2
14 isotype switching GO:0045190 9.43 MSH6 MSH2 MLH1
15 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.4 MSH2 MLH1
16 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MSH6 MSH2 MLH1
17 somatic hypermutation of immunoglobulin genes GO:0016446 9.26 PMS2 MSH6 MSH2 MLH1
18 mismatch repair GO:0006298 9.02 PMS2 PMS1 MSH6 MSH2 MLH1

Molecular functions related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 10.04 TP53 PMS2 PMS1 MSH6 MSH2 MLH1
2 chromatin binding GO:0003682 9.8 TP53 MSH6 MSH2 MLH1 AR
3 single-stranded DNA binding GO:0003697 9.69 PMS2 MSH2 MLH1
4 ATPase activity GO:0016887 9.65 PMS2 PMS1 MSH6 MSH2 MLH1
5 enzyme binding GO:0019899 9.63 TP53 PMS1 MSH6 MSH2 MLH1 AR
6 four-way junction DNA binding GO:0000400 9.52 MSH6 MSH2
7 MutSalpha complex binding GO:0032407 9.48 PMS2 MLH1
8 MutLalpha complex binding GO:0032405 9.46 MSH6 MSH2
9 oxidized purine DNA binding GO:0032357 9.43 MSH6 MSH2
10 single guanine insertion binding GO:0032142 9.37 MSH6 MSH2
11 single thymine insertion binding GO:0032143 9.32 MSH6 MSH2
12 guanine/thymine mispair binding GO:0032137 9.13 MSH6 MSH2 MLH1
13 mismatched DNA binding GO:0030983 9.02 PMS2 PMS1 MSH6 MSH2 MLH1

Sources for Sebaceous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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