MCID: SBC011
MIFTS: 43

Sebaceous Adenocarcinoma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Sebaceous Adenocarcinoma

MalaCards integrated aliases for Sebaceous Adenocarcinoma:

Name: Sebaceous Adenocarcinoma 12 15 17 71
Sebaceous Carcinoma 12 15
Adenocarcinoma of the Sebaceous Gland 12
Malignant Neoplasm of Sebaceous Gland 12
Malignant Sebaceous Neoplasm 71
Malignant Sebaceous Tumor 12
Sebaceous Gland Neoplasms 71
Adenocarcinoma, Sebaceous 44

Classifications:



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Disease Ontology 12 DOID:4839 DOID:4840
MeSH 44 D018266
NCIt 50 C40310 C8409
SNOMED-CT 67 188083002 54734006
ICD10 32 C44
UMLS 71 C0036503 C0206684 C1382026

Summaries for Sebaceous Adenocarcinoma

MalaCards based summary : Sebaceous Adenocarcinoma, also known as sebaceous carcinoma, is related to clear cell hidradenoma and sebaceous adenoma. An important gene associated with Sebaceous Adenocarcinoma is PLIN2 (Perilipin 2), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Anesthetics and Technetium Tc 99m Sulfur Colloid have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and salivary gland, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Sebaceous carcinoma, also known as sebaceous gland carcinoma (SGc), sebaceous cell carcinoma, and... more...

Related Diseases for Sebaceous Adenocarcinoma

Diseases related to Sebaceous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 342)
# Related Disease Score Top Affiliating Genes
1 clear cell hidradenoma 30.6 PIP KRT5
2 sebaceous adenoma 30.3 PMS2 PLIN2 MSH6 MSH2 MLH1
3 keratosis 30.3 TP53 KRT5 KRT14
4 meibomian cyst 30.2 PLIN2 PLIN1
5 malignant acrospiroma 30.2 PIP KRT5
6 in situ carcinoma 30.2 TP53 KRT5 KRT14 ERBB2
7 adenoma 30.2 TP53 MSH6 MSH2 MLH1
8 basal cell carcinoma 30.1 TP53 MSH2 MLH1 KRT5 KRT14 AR
9 squamous cell papilloma 30.1 TP53 KRT14
10 rectum cancer 30.0 MSH6 MSH2 MLH1
11 breast squamous cell carcinoma 30.0 KRT5 ERBB2
12 mammary paget's disease 30.0 PIP KRT14 ERBB2 AR
13 keratosis, seborrheic 29.9 TP53 MLANA KRT5
14 mismatch repair cancer syndrome 29.9 PMS2 MSH6 MSH2 MLH1
15 eccrine acrospiroma 29.9 PIP KRT5 KRT14
16 comedo carcinoma 29.8 TP53 ERBB2
17 pleomorphic adenoma carcinoma 29.8 TP53 ERBB2
18 lynch syndrome 29.7 TP53 PMS2 PMS1 MSH6 MSH2 MLH1
19 pleomorphic adenoma 29.7 TP53 KRT14 ERBB2 AR
20 mismatch repair cancer syndrome 1 29.6 PMS2 PMS1 MSH6 MSH2 MLH1
21 hereditary nonpolyposis colon cancer 29.6 PMS2 PMS1 MSH6 MSH2 MLH1
22 transitional cell carcinoma 29.5 TP53 MSH2 MLH1 ERBB2
23 papilloma 29.5 TP53 KRT5 KRT14 ERBB2
24 adenocarcinoma 29.3 TP53 MSH6 MSH2 MLH1 ERBB2
25 lipid-rich carcinoma 29.3 PLIN2 PIP KRT5 KRT14 ERBB2
26 mucoepidermoid carcinoma 29.2 TP53 KRT5 KRT14 ERBB2
27 colon adenocarcinoma 29.2 TP53 PMS2 MSH6 MLH1 ERBB2
28 paget disease, extramammary 29.2 PIP MLANA KRT5 ERBB2 AR
29 apocrine adenocarcinoma 29.2 TP53 PIP KRT5 ERBB2 AR
30 skin benign neoplasm 29.1 PIP MSH6 MSH2 MLH1 MLANA KRT5
31 colorectal adenocarcinoma 29.1 TP53 PMS2 MSH6 MSH2 MLH1 ERBB2
32 muir-torre syndrome 28.5 TP53 PTGER4 PMS2 PMS1 PLIN2 MSH6
33 skin carcinoma 27.8 TP53 PTGER4 PMS2 PIP MSH6 MSH2
34 vulvar sebaceous carcinoma 11.3
35 eyelid carcinoma 10.8
36 silent pituitary adenoma 10.4 MSH6 MSH2
37 spindle cell intraocular melanoma 10.4 PMS2 MLH1
38 intracranial meningioma 10.3 MSH2 MLH1
39 transverse colon cancer 10.3 PMS2 MLH1
40 periampullary adenoma 10.3 PMS2 MSH6
41 ascending colon cancer 10.3 MSH2 MLH1
42 lower lip cancer 10.3 MSH2 MLH1
43 ceruminoma 10.3 PIP KRT5
44 cutaneous mucoepidermoid carcinoma 10.3 PIP KRT5
45 cystic teratoma 10.3
46 teratoma 10.3
47 eccrine adenocarcinoma 10.3 PIP KRT5
48 esophageal tuberculosis 10.3 PMS2 MSH6
49 breast secretory carcinoma 10.3 PIP KRT5
50 urachus cancer 10.3 PMS1 PIP

Graphical network of the top 20 diseases related to Sebaceous Adenocarcinoma:



Diseases related to Sebaceous Adenocarcinoma

Symptoms & Phenotypes for Sebaceous Adenocarcinoma

GenomeRNAi Phenotypes related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.28 MLH1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.28 MLH1 TP53
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.28 MLH1 MSH2 MSH6 PMS1 PMS2 TP53

MGI Mouse Phenotypes related to Sebaceous Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.16 AR ERBB2 KRT14 MLH1 MSH2 MSH6
2 digestive/alimentary MP:0005381 10.09 AR ERBB2 KRT14 KRT5 MLH1 MSH2
3 hematopoietic system MP:0005397 10.07 AR KRT14 MLH1 MSH2 MSH6 PIP
4 homeostasis/metabolism MP:0005376 10.06 AR ERBB2 KRT14 MLH1 MSH2 MSH6
5 endocrine/exocrine gland MP:0005379 10.01 AR ERBB2 KRT14 MLH1 PIP PLIN2
6 immune system MP:0005387 10 AR KRT14 KRT5 MLH1 MSH2 MSH6
7 integument MP:0010771 9.93 AR ERBB2 KRT14 KRT5 MLANA MLH1
8 neoplasm MP:0002006 9.65 AR ERBB2 KRT14 MLH1 MSH2 MSH6
9 reproductive system MP:0005389 9.23 AR ERBB2 KRT14 MLH1 PIP PLIN2

Drugs & Therapeutics for Sebaceous Adenocarcinoma

Drugs for Sebaceous Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics Phase 2
2 Technetium Tc 99m Sulfur Colloid Phase 2
3 Radiopharmaceuticals Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sentinel Lymph Node Localization and Biopsy for Sebaceous Gland Carcinoma of the Eyelid Recruiting NCT00832429 Phase 2 Tc99m-Sulfur colloid
2 Research of Pathological Imaging Diagnosis of Ocular Tumors Based on New Artificial Intelligence Algorithm Not yet recruiting NCT04695015

Search NIH Clinical Center for Sebaceous Adenocarcinoma

Cochrane evidence based reviews: adenocarcinoma, sebaceous

Genetic Tests for Sebaceous Adenocarcinoma

Anatomical Context for Sebaceous Adenocarcinoma

MalaCards organs/tissues related to Sebaceous Adenocarcinoma:

40
Skin, Lymph Node, Salivary Gland, Ovary, Colon, Cervix, Eye

Publications for Sebaceous Adenocarcinoma

Articles related to Sebaceous Adenocarcinoma:

(show top 50) (show all 810)
# Title Authors PMID Year
1
Sebaceous Tumors of the Skin: A Study of 145 Lesions From 136 Patients Correlating Pathologic Features and DNA Mismatch Repair Staining Pattern. 61
33201015 2021
2
A case of Muir-Torre syndrome with a keratoacanthoma and sebaceous neoplasms: Clinicopathological features and a speculation on the pathogenesis of cutaneous tumor type. 61
33523490 2021
3
Risk of Rare Cancers Among Solid Organ Transplant Recipients. 61
32462187 2021
4
An updated review of the sebaceous gland and its role in health and diseases Part 2: Pathophysiological clinical disorders of sebaceous glands. 61
33571388 2021
5
Combined Merkel cell carcinoma and sebaceous carcinoma in the eyelid with cervical lymph node metastasis of both components. 61
33533503 2021
6
Epidemiology of cutaneous sebaceous carcinoma. 61
32632921 2021
7
Differences in 7th and 8th edition American Joint Committee on Cancer staging for periocular sebaceous carcinoma. 61
32822657 2021
8
Twenty-Eight Cases of Extraocular Sebaceous Carcinoma: A Correlative Clinicopathological and Immunohistochemical Analysis of Extraocular Sebaceous Carcinomas and Benign Sebaceous Gland Tumors. 61
32568835 2021
9
Sebaceous carcinoma of the vulva: a case report and review of the literature. 61
33520791 2021
10
Sebaceous Carcinoma Epidemiology and Genetics: Emerging Concepts and Clinical Implications for Screening, Prevention, and Treatment. 61
32907843 2021
11
Rapid Rehabilitation With Skin-Muscle Sparing Orbital Exenteration: A Single-Center Series. 61
32379171 2021
12
Sebaceous Carcinoma of the Eyelid: A Systematic Review and Meta-Analysis. 61
33347004 2021
13
PD-L1 expression in sebaceous carcinomas. 61
33398391 2021
14
Glioma-Associated Oncogene-1 Expression in Basal Cell Carcinoma and Its Histologic Mimics. 61
33264133 2020
15
An updated review of the sebaceous gland and its role in health and diseases Part 1: Embryology, evolution, structure, and function of sebaceous glands. 61
33354858 2020
16
Usefulness of ultrasonography in determining the surgical excision margin in non-melanocytic skin cancer: A comparative analysis of preoperative ultrasonography and postoperative histopathology. 61
33371149 2020
17
Nasolacrimal duct obstruction secondary to lacrimal sac involvement by sebaceous carcinoma. 61
31809621 2020
18
Sebaceous Carcinoma Incidence and Survival Among Solid Organ Transplant Recipients in the United States, 1987-2017. 61
33146669 2020
19
Sebaceous carcinoma of the caruncle: Excision and sentinel lymph node biopsy. 61
33372001 2020
20
Ocular Sebaceous Carcinoma In Situ With Biphenotypic Differentiation: A Reappraisal of the Alternative Origin of the Tumor. 61
32363990 2020
21
Eyelid carcinoma: An experience from a tertiary cancer center. 61
33380651 2020
22
Sebaceous Epithelial-Myoepithelial Carcinoma With Aggressive Behavior and Evidence of Preexisting Pleomorphic Adenoma. 61
33319619 2020
23
Unsuccessful palliative treatment of extraocular sebaceous carcinoma with shave removal and electrocoagulation. 61
33296543 2020
24
Sebaceous carcinoma of the axilla. 61
33391643 2020
25
High Expression of Programmed Death Ligand 1 and Programmed Death Ligand 2 in Ophthalmic Sebaceous Carcinoma: The Case for a Clinical Trial of Checkpoint Inhibitors. 61
32730911 2020
26
Extraocular sebaceous carcinoma as a rapidly growing back mass: a case report. 61
33342175 2020
27
18F-FDG PET/CT for Response Assessment in Pediatric Sebaceous Carcinoma of the Parotid Gland. 61
33172066 2020
28
Sebaceous carcinoma of the nose: For a difficult diagnosis, a challenging reconstruction. 61
32535987 2020
29
Localized sebaceous carcinoma treatment: Wide local excision verses Mohs micrographic surgery. 61
32645237 2020
30
Efficacy of Electrochemotherapy in the Treatment of Cutaneous Melanoma Metastases and Rare Non-melanoma Skin Cancer. 61
33109587 2020
31
An Unusual Histopathological Presentation of Epidermotropic Metastatic Pharyngeal Squamous Cell Carcinoma. 61
32568841 2020
32
Comprehensive germline mutation analysis and clinical profile in a large cohort of Brazilian xeroderma pigmentosum patients. 61
32239545 2020
33
Orbital exenteration and conjunctival melanoma: a 14-year study at the Jules Gonin Eye Hospital. 61
31959885 2020
34
A rare concurrence of Muir-Torre-associated sebaceous carcinoma in the setting of a lipedematous scalp. 61
33178881 2020
35
Deceptively Innocent Façade of Sebaceous Carcinoma in Muir-Torre Syndrome. 61
33038102 2020
36
Special type breast carcinoma: Sebaceous carcinoma of the breast; A case report and review of literature. 61
32623776 2020
37
Periocular skin cancer: Diagnosis and management. 61
32600650 2020
38
Periocular Sebaceous Carcinoma Masquerading as an Intratarsal Cyst. 61
31770178 2020
39
Dermoscopic clues for sebaceous carcinoma arising in nevus sebaceous. 61
32769491 2020
40
Clinical features and prognosis of sebaceous carcinoma arising in the eyelid or conjunctiva. 61
32642990 2020
41
Metastatic Prostatic Adenocarcinoma in Patient With Muir-Torre Syndrome Misdiagnosed as Metastatic Sebaceous Carcinoma: Case Report and Systematic Literature Review. 61
32568842 2020
42
Surgical management and lymph-node biopsy of rare malignant cutaneous adnexal carcinomas: a population-based analysis of 7591 patients. 61
32965516 2020
43
Use of endoscopic transorbital and endonasal approaches for 360° circumferential access to orbital tumors. 61
32977310 2020
44
Muir-Torre Syndrome Associated Periocular Sebaceous Neoplasms: Screening Patterns in the Literature and in Clinical Practice. 61
33005611 2020
45
Cutaneous sebaceous carcinoma. 61
31956994 2020
46
Pedunculated poorly differentiated papillary sebaceous carcinoma of the eyelid. 61
31020881 2020
47
Sebaceous carcinoma of the eyelid: 21-year experience in a Nordic country. 61
32749765 2020
48
Sebaceous Carcinoma In Situ of the External Auditory Canal. 61
32569248 2020
49
Whole-exome sequencing for ocular adnexal sebaceous carcinoma suggests PCDH15 as a novel mutation associated with metastasis. 61
31937901 2020
50
Dermoscopic features and differential diagnosis of sebaceous carcinoma. 61
32415798 2020

Variations for Sebaceous Adenocarcinoma

Expression for Sebaceous Adenocarcinoma

Search GEO for disease gene expression data for Sebaceous Adenocarcinoma.

Pathways for Sebaceous Adenocarcinoma

GO Terms for Sebaceous Adenocarcinoma

Cellular components related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.03 TP53 PMS2 PMS1 PLIN2 PIP MSH6
2 MutLalpha complex GO:0032389 9.16 PMS2 MLH1
3 mismatch repair complex GO:0032300 9.02 PMS2 PMS1 MSH6 MSH2 MLH1
4 MutSalpha complex GO:0032301 8.96 MSH6 MSH2

Biological processes related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.85 TP53 PMS2 PMS1 MSH6 MSH2 MLH1
2 response to drug GO:0042493 9.84 TP53 PMS2 PMS1 PLIN2
3 DNA repair GO:0006281 9.83 PMS2 PMS1 MSH6 MSH2 MLH1
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.63 MSH6 MSH2 MLH1
5 response to X-ray GO:0010165 9.57 TP53 MSH2
6 negative regulation of DNA recombination GO:0045910 9.56 MSH6 MSH2
7 hemidesmosome assembly GO:0031581 9.55 KRT5 KRT14
8 positive regulation of isotype switching to IgG isotypes GO:0048304 9.52 MSH2 MLH1
9 positive regulation of helicase activity GO:0051096 9.51 MSH6 MSH2
10 determination of adult lifespan GO:0008340 9.5 TP53 MSH6 MSH2
11 positive regulation of isotype switching to IgA isotypes GO:0048298 9.49 MSH2 MLH1
12 maintenance of DNA repeat elements GO:0043570 9.48 MSH6 MSH2
13 isotype switching GO:0045190 9.43 MSH6 MSH2 MLH1
14 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.4 MSH2 MLH1
15 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MSH6 MSH2 MLH1
16 somatic hypermutation of immunoglobulin genes GO:0016446 9.26 PMS2 MSH6 MSH2 MLH1
17 mismatch repair GO:0006298 9.02 PMS2 PMS1 MSH6 MSH2 MLH1

Molecular functions related to Sebaceous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 10.04 TP53 PMS2 PMS1 MSH6 MSH2 MLH1
2 chromatin binding GO:0003682 9.8 TP53 MSH6 MSH2 MLH1 AR
3 single-stranded DNA binding GO:0003697 9.69 PMS2 MSH2 MLH1
4 ATPase activity GO:0016887 9.65 PMS2 PMS1 MSH6 MSH2 MLH1
5 enzyme binding GO:0019899 9.63 TP53 PMS1 MSH6 MSH2 MLH1 AR
6 four-way junction DNA binding GO:0000400 9.52 MSH6 MSH2
7 MutSalpha complex binding GO:0032407 9.48 PMS2 MLH1
8 MutLalpha complex binding GO:0032405 9.46 MSH6 MSH2
9 oxidized purine DNA binding GO:0032357 9.43 MSH6 MSH2
10 single guanine insertion binding GO:0032142 9.37 MSH6 MSH2
11 single thymine insertion binding GO:0032143 9.32 MSH6 MSH2
12 guanine/thymine mispair binding GO:0032137 9.13 MSH6 MSH2 MLH1
13 mismatched DNA binding GO:0030983 9.02 PMS2 PMS1 MSH6 MSH2 MLH1

Sources for Sebaceous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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