MCID: SBC009
MIFTS: 35

Sebaceous Adenoma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Sebaceous Adenoma

MalaCards integrated aliases for Sebaceous Adenoma:

Name: Sebaceous Adenoma 12 15 71
Skin Appendage Sebaceous Adenoma 12
Adenoma of the Sebaceous Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2648
NCIt 49 C4174
SNOMED-CT 67 78424008
UMLS 71 C1368816

Summaries for Sebaceous Adenoma

MalaCards based summary : Sebaceous Adenoma, also known as skin appendage sebaceous adenoma, is related to adenoma and myh-associated polyposis. An important gene associated with Sebaceous Adenoma is MSH2 (MutS Homolog 2), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Endometrial cancer. Affiliated tissues include skin, breast and colon, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

Wikipedia : 74 A sebaceous adenoma, a type of adenoma, a cutaneous condition characterized by a slow-growing tumor... more...

Related Diseases for Sebaceous Adenoma

Diseases related to Sebaceous Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 adenoma 31.1 MUTYH MSH6 MSH2 MLH1
2 myh-associated polyposis 30.2 MUTYH MSH2
3 keratoacanthoma 29.9 MSH2 MLH1 KRT15
4 colon adenocarcinoma 29.7 PMS2 MSH6 MLH1 EGF
5 sebaceous adenocarcinoma 29.6 PMS2 PLIN2 MSH6 MSH2 MLH1
6 muir-torre syndrome 29.6 PMS2 PLIN2 MUTYH MSH6 MSH2 MLH1
7 lynch syndrome 29.4 PMS2 MUTYH MSH6 MSH2 MLH1
8 glioblastoma multiforme 29.4 PMS2 MSH2 MLH1 ESR1 EGF
9 sebaceous gland neoplasm 25.5 SERPINA3 PMS2 PLIN2 PLET1 MUTYH MSH6
10 jejunal adenocarcinoma 10.3 MSH6 MLH1
11 spindle cell intraocular melanoma 10.3 PMS2 MLH1
12 xanthogranulomatous pyelonephritis 10.3 SERPINA3 EGF
13 periampullary adenoma 10.3 PMS2 MSH6
14 ascending colon cancer 10.3 MSH2 MLH1
15 lower lip cancer 10.3 MSH2 MLH1
16 adenomyoma 10.3 MLH1 ESR1
17 breast malignant phyllodes tumor 10.3 SERPINA3 ESR1
18 colorectal cancer, hereditary nonpolyposis, type 4 10.3 PMS2 MLH1
19 legius syndrome 10.3 MSH6 MSH2
20 melanocytic nevus syndrome, congenital 10.3 MSH2 MLH1
21 lipid-rich carcinoma 10.3 PLIN2 ESR1
22 fallopian tube endometrioid adenocarcinoma 10.3 PMS2 MSH6
23 apocrine adenocarcinoma 10.3 SERPINA3 ESR1
24 ovarian endometrial cancer 10.2 SERPINA3 ESR1
25 polyposis syndrome, hereditary mixed, 1 10.2 MUTYH MLH1
26 cervical mucinous adenocarcinoma 10.2 MSH6 MSH2 ESR1
27 anal fistula 10.2 MSH2 MLH1 EGF
28 adenosarcoma 10.2 SERPINA3 ESR1
29 gastrointestinal adenoma 10.2 PMS2 MUTYH
30 endometrial adenocarcinoma 10.2 MLH1 ESR1 EGF
31 renal pelvis transitional cell carcinoma 10.2 MSH6 MSH2 MLH1
32 ureter, cancer of 10.2 MSH2 MLH1
33 cervical adenoma malignum 10.2 MSH6 MSH2 MLH1
34 autosomal dominant non-syndromic intellectual disability 8 10.2 MSH6 MSH2 MLH1
35 mental retardation, autosomal dominant 20 10.2 MSH6 MSH2 MLH1
36 prostatic hypertrophy 10.2 SERPINA3 ESR1 EGF
37 dysplastic nevus syndrome 10.2 MSH6 MSH2 MLH1
38 uterine corpus cancer 10.2 MSH6 MLH1 ESR1
39 cecum carcinoma 10.1 MSH2 MLH1
40 rectum signet ring adenocarcinoma 10.1 PMS2 MSH2 MLH1
41 malignant ovarian surface epithelial-stromal neoplasm 10.1 SERPINA3 ESR1 EGF
42 ovary epithelial cancer 10.1 SERPINA3 ESR1 EGF
43 uterine carcinosarcoma 10.1 MSH2 MLH1 ESR1
44 signet ring cell adenocarcinoma 10.1 SERPINA3 MSH2 MLH1
45 attenuated familial adenomatous polyposis 10.1 MUTYH MSH6 MSH2
46 thoracic benign neoplasm 10.1 SERPINA3 ESR1
47 tuberous sclerosis 10.1
48 cystic teratoma 10.1
49 teratoma 10.1
50 rare tumor 10.1

Graphical network of the top 20 diseases related to Sebaceous Adenoma:



Diseases related to Sebaceous Adenoma

Symptoms & Phenotypes for Sebaceous Adenoma

GenomeRNAi Phenotypes related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 MLH1 MSH2 MSH6 MUTYH PMS2

MGI Mouse Phenotypes related to Sebaceous Adenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.96 ESR1 KRT15 LRIG1 MLH1 MSH2 MSH6
2 digestive/alimentary MP:0005381 9.92 EGF ESR1 KRT15 LRIG1 MLH1 MSH2
3 immune system MP:0005387 9.76 EGF ESR1 LRIG1 MLH1 MSH2 MSH6
4 integument MP:0010771 9.5 EGF ESR1 LRIG1 MLH1 MSH2 MSH6
5 neoplasm MP:0002006 9.23 ESR1 LRIG1 MLH1 MSH2 MSH6 MUTYH

Drugs & Therapeutics for Sebaceous Adenoma

Search Clinical Trials , NIH Clinical Center for Sebaceous Adenoma

Genetic Tests for Sebaceous Adenoma

Anatomical Context for Sebaceous Adenoma

MalaCards organs/tissues related to Sebaceous Adenoma:

40
Skin, Breast, Colon, Ovary, Salivary Gland, Brain, Small Intestine

Publications for Sebaceous Adenoma

Articles related to Sebaceous Adenoma:

(show top 50) (show all 174)
# Title Authors PMID Year
1
Sebaceous Adenoma in a Patient With Visceral Malignancies. 61
31923095 2020
2
Cytologic features of sebaceous, lymphadenoma, and sebaceous lymphadenocarcinoma: Differential diagnostic considerations. 61
31967730 2020
3
Update on the Pathology, Genetics and Somatic Landscape of Sebaceous Tumours. 61
31821583 2019
4
Loss of ZNF750 in ocular and cutaneous sebaceous carcinoma. 61
31148199 2019
5
Sebaceous adenoma in the setting of immunosuppression for kidney transplantation. 61
31508474 2019
6
CDKN2A, CDK1, and CCNE1 overexpression in sebaceous gland carcinoma of eyelid. 61
31571090 2019
7
Utility of Ber-EP4 and MOC-31 in Basaloid Skin Tumor Detection. 61
29629953 2019
8
Multiple benign adnexal tumours: Anything but benign. 61
30671930 2019
9
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours. 61
31209701 2019
10
Spatial analysis of p63, K5 and K7 defines two groups of progenitor cells that differentially contribute to the maintenance of normal sebaceous glands, extraocular sebaceous carcinoma and benign sebaceous tumors. 61
30663115 2019
11
Frequent TLE1 Expression in Cutaneous Neoplasms. 61
30608261 2019
12
Muir-Torre Syndrome: A Case Report in a Woman Without Personal Cancer History. 61
29933315 2019
13
An unusual case of tuberous sclerosis incidentally discovered in adulthood: case report and review of the literature. 61
30619624 2018
14
Sebaceous tumours: more than skin deep. 61
29247065 2018
15
Analysis of histologic follow-up and risk of malignancy for salivary gland neoplasm of uncertain malignant potential proposed by the Milan System for Reporting Salivary Gland Cytopathology. 61
29669190 2018
16
Evaluation of universal immunohistochemical screening of sebaceous neoplasms in a service setting. 61
29333623 2018
17
Electrochemotherapy with Bleomycin of Different types of Cutaneous Tumours in a Ferret (Mustela Putorius Furo). 61
29520211 2018
18
Evaluation and comparison of staining patterns of factor XIIIa (AC-1A1), adipophilin and GATA3 in sebaceous neoplasia. 61
28873247 2018
19
Desmoplastic Fibroma Recurrence Associated with Tuberous Sclerosis in a Young Patient. 61
29850273 2018
20
Sebaceous lesions of the skin. 61
29078997 2017
21
TdT expression in normal and neoplastic sebaceous cells. 61
28677299 2017
22
Intra-oral Sebaceous Gland Tumours in Two Dogs. 61
29169626 2017
23
Identification of MSH2 inversion of exons 1-7 in clinical evaluation of families with suspected Lynch syndrome. 61
28004223 2017
24
Sebaceous Neoplasms. 61
28477886 2017
25
A case report of Muir-Torre syndrome in a woman with breast cancer and MSI-Low skin squamous cell carcinoma. 61
28507641 2017
26
Sebaceous adenoma arising in mature cystic teratoma of the ovary. Case report. 61
28248120 2017
27
Clinicopathological study of 47 cases of sebaceoma. 61
27836252 2016
28
Cutaneous Sebaceous Lesions in a Patient With MUTYH-Associated Polyposis Mimicking Muir-Torre Syndrome. 61
27870730 2016
29
Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a sensitive and specific marker to discriminate sebaceous proliferations from other cutaneous clear cell neoplasms. 61
27153339 2016
30
Circumscribed sebaceous neoplasms: a morphological, immunohistochemical and molecular analysis. 61
27311873 2016
31
Epidermal CYLD inactivation sensitizes mice to the development of sebaceous and basaloid skin tumors. 61
27478875 2016
32
A unique case of isolated sebaceous adenoma of the bulbar conjunctiva. 61
27626151 2016
33
GATA3 Expression in Normal Skin and in Benign and Malignant Epidermal and Cutaneous Adnexal Neoplasms. 61
26595821 2015
34
Sebaceous Adenoma of the Caruncle. 61
26398052 2015
35
Distinct pathways in the pathogenesis of sebaceous carcinomas implicated by differentially expressed microRNAs. 61
26203913 2015
36
[The tip of the iceberg: multiple cutaneous sebaceous tumor in colon cancer. Muir-Torre syndrome--case report]. 61
26051134 2015
37
Sebaceous adenoma: clinics, dermatoscopy, and histopathology. 61
25311786 2015
38
The role of immunohistochemistry in the Muir-Torre Syndrome. 61
26312706 2015
39
Muir-Torre syndrome. 61
25427047 2014
40
Fine-needle aspiration cytomorphology of sebaceous lymphadenoma of the salivary gland. 61
24376220 2014
41
[Differential diagnostics of sebaceous tumors]. 61
25103328 2014
42
[Cutaneous adnexal and salivary gland tumours. Similarities and differences]. 61
25103327 2014
43
Preferential expression of OVOL1 in inner root sheath of hair, sebaceous gland, eccrine duct and their neoplasms in human skin. 61
25509883 2014
44
Corneal limbal sebaceous adenoma. 61
24556852 2014
45
Clear cell myoepithelioma of palate with emphasis on clinical and histological differential diagnosis. 61
24847433 2014
46
Androgen receptor identification in the diagnosis of eyelid sebaceous carcinomas. 61
24333189 2014
47
Synchronous gastric and sebaceous cancers, a rare manifestation of MLH1-related Muir-Torre syndrome. 61
25197397 2014
48
Tumours of the skin adnexa: a case series with focus on multiple segmental forms. 61
24730337 2013
49
Interobserver variability in the diagnosis of circumscribed sebaceous neoplasms of the skin. 61
24018813 2013
50
Muir-Torre syndrome in a haemodialysis patient. 61
27293570 2013

Variations for Sebaceous Adenoma

Expression for Sebaceous Adenoma

Search GEO for disease gene expression data for Sebaceous Adenoma.

Pathways for Sebaceous Adenoma

Pathways related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 PMS2 MUTYH MSH6 MSH2 MLH1
2
Show member pathways
12.56 MSH6 MSH2 MLH1 EGF
3 12.38 MSH6 MSH2 MLH1 ESR1 EGF
4 12.14 MUTYH MSH6 MSH2 MLH1
5 11.82 MSH6 MSH2 ESR1
6 11.73 PMS2 MSH2 MLH1
7 11.67 MSH6 MSH2 MLH1 EGF
8
Show member pathways
11.61 LRIG1 ESR1 EGF
9 11.36 MSH6 MSH2 MLH1
10
Show member pathways
11.23 PMS2 MSH6 MSH2 MLH1
11 11.03 LRIG1 EGF
12 10.39 PMS2 MSH6 MSH2 MLH1

GO Terms for Sebaceous Adenoma

Cellular components related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 9.16 PMS2 MLH1
2 MutSalpha complex GO:0032301 8.96 MSH6 MSH2
3 mismatch repair complex GO:0032300 8.92 PMS2 MSH6 MSH2 MLH1

Biological processes related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.88 PMS2 MUTYH MSH6 MSH2 MLH1
2 DNA repair GO:0006281 9.77 PMS2 MUTYH MSH6 MSH2 MLH1
3 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.58 MSH6 MSH2 MLH1
4 determination of adult lifespan GO:0008340 9.56 MSH6 MSH2
5 mammary gland alveolus development GO:0060749 9.55 ESR1 EGF
6 negative regulation of DNA recombination GO:0045910 9.54 MSH6 MSH2
7 protein localization to chromatin GO:0071168 9.52 MSH2 ESR1
8 positive regulation of isotype switching to IgG isotypes GO:0048304 9.51 MSH2 MLH1
9 positive regulation of helicase activity GO:0051096 9.49 MSH6 MSH2
10 positive regulation of isotype switching to IgA isotypes GO:0048298 9.46 MSH2 MLH1
11 maintenance of DNA repeat elements GO:0043570 9.43 MSH6 MSH2
12 isotype switching GO:0045190 9.43 MSH6 MSH2 MLH1
13 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MSH6 MSH2 MLH1
14 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MSH2 MLH1
15 somatic hypermutation of immunoglobulin genes GO:0016446 9.26 PMS2 MSH6 MSH2 MLH1
16 mismatch repair GO:0006298 9.02 PMS2 MUTYH MSH6 MSH2 MLH1

Molecular functions related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.81 MSH6 MSH2 MLH1 ESR1
2 enzyme binding GO:0019899 9.78 MSH6 MSH2 MLH1 ESR1
3 ATPase activity GO:0016887 9.73 PMS2 MSH6 MSH2 MLH1
4 single-stranded DNA binding GO:0003697 9.63 PMS2 MSH2 MLH1
5 MutSalpha complex binding GO:0032407 9.5 PMS2 MUTYH MLH1
6 four-way junction DNA binding GO:0000400 9.49 MSH6 MSH2
7 MutLalpha complex binding GO:0032405 9.43 MUTYH MSH6 MSH2
8 single guanine insertion binding GO:0032142 9.4 MSH6 MSH2
9 single thymine insertion binding GO:0032143 9.37 MSH6 MSH2
10 oxidized purine DNA binding GO:0032357 9.33 MUTYH MSH6 MSH2
11 guanine/thymine mispair binding GO:0032137 9.13 MSH6 MSH2 MLH1
12 mismatched DNA binding GO:0030983 8.92 PMS2 MSH6 MSH2 MLH1

Sources for Sebaceous Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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