MCID: SBC009
MIFTS: 39

Sebaceous Adenoma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Sebaceous Adenoma

MalaCards integrated aliases for Sebaceous Adenoma:

Name: Sebaceous Adenoma 12 15 73
Skin Appendage Sebaceous Adenoma 12
Adenoma of the Sebaceous Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2648
NCIt 50 C4174
SNOMED-CT 68 78424008
UMLS 73 C1368816

Summaries for Sebaceous Adenoma

MalaCards based summary : Sebaceous Adenoma, also known as skin appendage sebaceous adenoma, is related to muir-torre syndrome and sebaceous adenocarcinoma. An important gene associated with Sebaceous Adenoma is EGF (Epidermal Growth Factor), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Endometrial cancer. Affiliated tissues include skin, kidney and bone, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and digestive/alimentary

Wikipedia : 76 A sebaceous adenoma, a type of adenoma, a cutaneous condition characterized by a slow-growing tumor... more...

Related Diseases for Sebaceous Adenoma

Diseases related to Sebaceous Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 muir-torre syndrome 29.7 MLH1 MSH2 MSH6 PMS2
2 sebaceous adenocarcinoma 29.1 MLH1 MSH2 MSH6 PMS2
3 colorectal cancer 28.9 EGF MLH1 MSH2 MSH6 PMS2
4 adenoma 10.7
5 prostatic hypertrophy 10.1 EGF ESR1
6 estrogen-receptor negative breast cancer 10.1 EGF ESR1
7 attenuated familial adenomatous polyposis 10.0 MSH2 MSH6
8 cystic teratoma 10.0
9 teratoma 10.0
10 legius syndrome 10.0 MSH2 MSH6
11 breast giant fibroadenoma 10.0 ESR1 PMS2
12 insulin-like growth factor i 9.9 EGF ESR1
13 colorectal cancer, hereditary nonpolyposis, type 7 9.9 MLH1 MSH2
14 colorectal cancer 5 9.9 MLH1 MSH6
15 lower lip cancer 9.9 MLH1 MSH2
16 neurofibromatosis, type iv, of riccardi 9.9 MSH6 PMS2
17 gastric leiomyoma 9.9 MLH1 MSH6
18 melanocytic nevus syndrome, congenital 9.9 MLH1 MSH2
19 breast disease 9.9 EGF ESR1 MSH2
20 childhood kidney cell carcinoma 9.9 MLH1 MSH2
21 spindle cell intraocular melanoma 9.9 MLH1 PMS2
22 intestinal benign neoplasm 9.9 MLH1 MSH2
23 keratoacanthoma 9.9 MLH1 MSH2
24 leukemia, chronic lymphocytic 2 9.9
25 multiple sclerosis 9.9
26 glioma susceptibility 1 9.9
27 leukemia, chronic lymphocytic 9.9
28 gastrointestinal carcinoma 9.9
29 lymphocytic leukemia 9.9
30 glioblastoma multiforme 9.9
31 adenosquamous carcinoma 9.9
32 syringocystadenoma papilliferum 9.9
33 acquired immunodeficiency syndrome 9.9
34 follicular infundibulum tumor 9.9
35 mutyh-associated polyposis 9.9
36 glioblastoma 9.9
37 leukemia, b-cell, chronic 9.9
38 familial colorectal cancer 9.9 MLH1 MSH2
39 colorectal adenoma 9.9 MLH1 MSH2
40 hereditary breast ovarian cancer syndrome 9.8 MLH1 MSH6
41 reproductive system disease 9.8 EGF ESR1 MLH1
42 rectal neoplasm 9.8 MLH1 MSH2
43 endometrial adenocarcinoma 9.8 ESR1 MLH1
44 anal fistula 9.8 EGF MLH1 MSH2
45 rhabdomyosarcoma 9.8 MSH2 MSH6 PMS2
46 cecum adenocarcinoma 9.7 MLH1 MSH2 MSH6
47 skin benign neoplasm 9.7 MLH1 MSH2 MSH6
48 colorectal cancer, hereditary nonpolyposis, type 5 9.7 MLH1 MSH2 MSH6
49 colorectal adenocarcinoma 9.7 MLH1 MSH2 MSH6
50 familial adenomatous polyposis 9.7 MLH1 MSH2 MSH6

Graphical network of the top 20 diseases related to Sebaceous Adenoma:



Diseases related to Sebaceous Adenoma

Symptoms & Phenotypes for Sebaceous Adenoma

GenomeRNAi Phenotypes related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.92 MLH1 MSH2 MSH6 PMS2

MGI Mouse Phenotypes related to Sebaceous Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.72 EGF ESR1 MLH1 MSH2 PMS2
2 hematopoietic system MP:0005397 9.65 ESR1 MLH1 MSH2 MSH6 PMS2
3 immune system MP:0005387 9.63 EGF ESR1 MLH1 MSH2 MSH6 PMS2
4 integument MP:0010771 9.35 EGF ESR1 MLH1 MSH2 MSH6
5 neoplasm MP:0002006 9.02 ESR1 MLH1 MSH2 MSH6 PMS2

Drugs & Therapeutics for Sebaceous Adenoma

Search Clinical Trials , NIH Clinical Center for Sebaceous Adenoma

Genetic Tests for Sebaceous Adenoma

Anatomical Context for Sebaceous Adenoma

MalaCards organs/tissues related to Sebaceous Adenoma:

41
Skin, Kidney, Bone, Colon, B Cells, Small Intestine, Appendix

Publications for Sebaceous Adenoma

Articles related to Sebaceous Adenoma:

(show all 49)
# Title Authors Year
1
Sebaceous adenoma arising in mature cystic teratoma of the ovary. Case report. ( 28248120 )
2017
2
A unique case of isolated sebaceous adenoma of the bulbar conjunctiva. ( 27626151 )
2016
3
Sebaceous Adenoma of the Caruncle. ( 26398052 )
2015
4
Corneal limbal sebaceous adenoma. ( 24556852 )
2014
5
Sebaceous adenoma: clinics, dermatoscopy, and histopathology. ( 25311786 )
2014
6
A case of sebaceous adenoma of the eyelid showing excessively rapid growth. ( 23579539 )
2013
7
Sebaceous adenoma arising within an ovarian mature cystic teratoma in Muir-Torre syndrome. ( 21684182 )
2012
8
Metachronous occurrence of colorectal cancer in a muir-torre syndrome patient presenting with recurrent sebaceous adenoma of the eyelid: case report and updated review of the literature. ( 23149194 )
2012
9
A rare case of sebaceous adenoma of the palate, with literature review. ( 21443818 )
2011
10
Treatment of sebaceous adenoma with topical photodynamic therapy. ( 20956668 )
2010
11
Mucoepidermoid (adenosquamous) carcinoma, trichoblastoma, trichilemmoma, sebaceous adenoma, tumor of follicular infundibulum and syringocystadenoma papilliferum arising within 2 persistent lesions of nevus sebaceous: report of a case. ( 19652586 )
2009
12
Sebaceous adenoma of the submandibular gland: a case report. ( 20032620 )
2009
13
Demodex-associated dermatologic conditions--A coincidence or an etiological correlate. Review with a report of a rare case of sebaceous adenoma. ( 19167837 )
2009
14
Comparative clinicopathological study of intraoral sebaceous hyperplasia and sebaceous adenoma. ( 19101492 )
2009
15
Sebaceous adenoma of the parotid gland: a case report with fine needle aspiration findings and histologic correlation. ( 19697727 )
2009
16
Sebaceous adenoma of the parotid gland in a 2-year-old male. ( 17418275 )
2007
17
Sebaceous adenoma of the bulbar conjunctiva in association with glioblastoma multiforme and chronic lymphocytic leukemia. ( 17893552 )
2007
18
Penile sebaceous adenoma. ( 17637371 )
2007
19
Sebaceous adenoma of the parotid gland. ( 16878064 )
2006
20
Sebaceous adenoma of the eyelid in Muir-Torre syndrome. ( 15824235 )
2005
21
Sebaceous adenoma of oral cavity: report of case and comparative proliferation study with sebaceous gland hyperplasia and Fordyce's granules. ( 14629335 )
2003
22
Sebaceous adenoma in the retromolar region: report of a case with a review of the English literature. ( 14505629 )
2003
23
Sebaceous adenoma in the submandibular gland. ( 11870356 )
2002
24
Loss of p21(WAF1) compartmentalisation in sebaceous carcinoma compared with sebaceous hyperplasia and sebaceous adenoma. ( 12354803 )
2002
25
Sebaceous adenoma of the cheek. ( 11755830 )
2002
26
Solitary facial lesion. Sebaceous adenoma in association with Muir-Torre syndrome (MTS). ( 9006382 )
1997
27
Sebaceous adenoma of the submandibular gland: a case report. ( 8863311 )
1996
28
Immunohistochemical study on sebaceous adenoma and sebaceous carcinoma arising in parotid gland. ( 21594425 )
1996
29
Sebaceous adenoma with a cutaneous horn. ( 7560356 )
1995
30
Sebaceous adenoma in the region of the medial canthus causing proptosis. ( 10707724 )
1995
31
CT of sebaceous adenoma of the parotid gland. ( 7976936 )
1994
32
Sebaceous adenoma of parotid gland--a rare tumour diagnosed by fine needle aspiration cytology. ( 7880973 )
1994
33
Sebaceous adenoma in a patient with acquired immunodeficiency syndrome. ( 3355190 )
1988
34
Sebaceous adenoma of the oral mucosa. ( 3469349 )
1987
35
Pathology quiz case 1: Sebaceous adenoma. ( 6849571 )
1983
36
Sebaceous adenoma of the oral cavity. ( 6571741 )
1983
37
Tissue connections in a transplantable virus-producing sebaceous adenoma of the mouse. II. A freeze-fracture study in conjunction with filipin. ( 6277960 )
1982
38
Tissue connections in a transplantable virus-producing sebaceous adenoma of the mouse. ( 7338533 )
1981
39
Sebaceous adenoma of the eyelid and visceral malignancy. ( 4440729 )
1974
40
A SEBACEOUS ADENOMA. HISTOLOGICAL AND CHEMICAL STUDIES. ( 14183145 )
1964
41
Sebaceous adenoma of the submaxillary salivary gland. Report of a case. ( 14011757 )
1963
42
A REVIEW ON SEBACEOUS ADENOMA WITH REPORT OF A CASE IN THE EXTERNAL AUDITORY MEATUS. ( 14082064 )
1963
43
Sebaceous adenoma in a dog. ( 13407925 )
1957
44
Scalp: sebaceous adenoma. ( 13094140 )
1953
45
Diethylstilbestrol in the treatment of senile sebaceous adenoma. ( 14952023 )
1952
46
Sebaceous adenoma; review of the literature and report of a case. ( 18919779 )
1948
47
Senile Sebaceous Adenoma. ( 19991727 )
1938
48
Pringle Type of Sebaceous Adenoma. ( 19990196 )
1935
49
Sebaceous Adenoma (Pringle Type) in Mother and Daughter. ( 19979593 )
1917

Variations for Sebaceous Adenoma

Expression for Sebaceous Adenoma

Search GEO for disease gene expression data for Sebaceous Adenoma.

Pathways for Sebaceous Adenoma

Pathways related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.8 MLH1 MSH2 MSH6 PMS2
2
Show member pathways
12.45 EGF MLH1 MSH2 MSH6
3
Show member pathways
12.42 EGF ESR1 MSH6
4
Show member pathways
12.41 EGF ESR1 MLH1
5
Show member pathways
12.34 ESR1 MSH2 MSH6
6 12.27 EGF ESR1 MLH1 MSH2 MSH6
7 12.12 MLH1 MSH2 MSH6
8 11.8 ESR1 MSH2 MSH6
9 11.78 EGF MLH1 MSH2 MSH6
10 11.66 MLH1 MSH2 PMS2
11
Show member pathways
11.63 EGF ESR1
12 11.56 MLH1 PMS2
13
Show member pathways
11.5 MSH2 MSH6
14 11.37 EGF ESR1
15 11.36 MLH1 MSH2 MSH6
16
Show member pathways
11.25 MLH1 MSH2 MSH6 PMS2
17 11.23 MLH1 MSH2 MSH6
18 11.2 MSH2 MSH6
19
Show member pathways
11.17 MLH1 MSH2
20
Show member pathways
11.11 MLH1 MSH2
21 10.39 MLH1 MSH2 MSH6 PMS2

GO Terms for Sebaceous Adenoma

Cellular components related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.65 ESR1 MLH1 MSH2 MSH6 PMS2
2 MutLalpha complex GO:0032389 9.16 MLH1 PMS2
3 MutSalpha complex GO:0032301 8.96 MSH2 MSH6
4 mismatch repair complex GO:0032300 8.92 MLH1 MSH2 MSH6 PMS2

Biological processes related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.84 MLH1 MSH2 MSH6 PMS2
2 DNA repair GO:0006281 9.78 MLH1 MSH2 MSH6 PMS2
3 male gonad development GO:0008584 9.6 ESR1 MSH2
4 interstrand cross-link repair GO:0036297 9.59 MSH2 MSH6
5 mammary gland alveolus development GO:0060749 9.58 EGF ESR1
6 negative regulation of DNA recombination GO:0045910 9.58 MSH2 MSH6
7 determination of adult lifespan GO:0008340 9.57 MSH2 MSH6
8 protein localization to chromatin GO:0071168 9.56 ESR1 MSH2
9 positive regulation of isotype switching to IgG isotypes GO:0048304 9.55 MLH1 MSH2
10 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.54 MLH1 MSH2 MSH6
11 positive regulation of helicase activity GO:0051096 9.52 MSH2 MSH6
12 pyrimidine dimer repair GO:0006290 9.51 MSH2 MSH6
13 replication fork arrest GO:0043111 9.49 MSH2 MSH6
14 maintenance of DNA repeat elements GO:0043570 9.46 MSH2 MSH6
15 positive regulation of isotype switching to IgA isotypes GO:0048298 9.43 MLH1 MSH2
16 isotype switching GO:0045190 9.43 MLH1 MSH2 MSH6
17 meiotic mismatch repair GO:0000710 9.4 MSH2 MSH6
18 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MLH1 MSH2 MSH6
19 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MLH1 MSH2
20 mismatch repair GO:0006298 9.26 MLH1 MSH2 MSH6 PMS2
21 somatic hypermutation of immunoglobulin genes GO:0016446 8.92 MLH1 MSH2 MSH6 PMS2

Molecular functions related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.87 MLH1 MSH2 MSH6 PMS2
2 chromatin binding GO:0003682 9.71 ESR1 MLH1 MSH2 MSH6
3 single-stranded DNA binding GO:0003697 9.67 MLH1 MSH2 PMS2
4 enzyme binding GO:0019899 9.67 ESR1 MLH1 MSH2 MSH6
5 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.56 EGF ESR1
6 damaged DNA binding GO:0003684 9.55 MSH2 MSH6
7 DNA-dependent ATPase activity GO:0008094 9.54 MSH2 MSH6
8 ADP binding GO:0043531 9.52 MSH2 MSH6
9 four-way junction DNA binding GO:0000400 9.51 MSH2 MSH6
10 MutLalpha complex binding GO:0032405 9.48 MSH2 MSH6
11 MutSalpha complex binding GO:0032407 9.46 MLH1 PMS2
12 ATPase activity GO:0016887 9.46 MLH1 MSH2 MSH6 PMS2
13 oxidized purine DNA binding GO:0032357 9.43 MSH2 MSH6
14 single thymine insertion binding GO:0032143 9.32 MSH2 MSH6
15 single guanine insertion binding GO:0032142 9.26 MSH2 MSH6
16 guanine/thymine mispair binding GO:0032137 9.13 MLH1 MSH2 MSH6
17 mismatched DNA binding GO:0030983 8.92 MLH1 MSH2 MSH6 PMS2

Sources for Sebaceous Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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