MCID: SBC009
MIFTS: 36

Sebaceous Adenoma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Sebaceous Adenoma

MalaCards integrated aliases for Sebaceous Adenoma:

Name: Sebaceous Adenoma 12 15 70
Skin Appendage Sebaceous Adenoma 12
Adenoma of the Sebaceous Gland 12
Sebaceous Adenomas 6

Classifications:



External Ids:

Disease Ontology 12 DOID:2648
NCIt 50 C4174
SNOMED-CT 67 78424008
UMLS 70 C1368816

Summaries for Sebaceous Adenoma

MalaCards based summary : Sebaceous Adenoma, also known as skin appendage sebaceous adenoma, is related to adenoma and myh-associated polyposis. An important gene associated with Sebaceous Adenoma is TSC1 (TSC Complex Subunit 1), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Endometrial cancer. Affiliated tissues include skin, breast and colon, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Wikipedia : 73 A sebaceous adenoma, a type of adenoma, a cutaneous condition characterized by a slow-growing tumor... more...

Related Diseases for Sebaceous Adenoma

Diseases related to Sebaceous Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 adenoma 30.6 TSC1 MUTYH MSH6 MSH2 MLH1
2 myh-associated polyposis 30.0 MUTYH MSH2
3 familial adenomatous polyposis 2 29.9 MUTYH MLH1
4 attenuated familial adenomatous polyposis 29.8 MUTYH MSH6 MSH2
5 keratoacanthoma 29.6 MSH2 MLH1 KRT15
6 sebaceous adenocarcinoma 29.5 PMS2 PLIN2 MSH6 MSH2 MLH1
7 colon adenocarcinoma 29.5 PMS2 MSH6 MLH1 ESR1 EGF
8 muir-torre syndrome 29.5 PMS2 PLIN2 MUTYH MSH6 MSH2 MLH1
9 lynch syndrome 29.1 PMS2 MUTYH MSH6 MSH2 MLH1
10 sebaceous gland neoplasm 27.0 SERPINA3 PMS2 PLIN2 PLET1 MUTYH MSH6
11 adenosarcoma 10.3 SERPINA3 ESR1
12 colorectal cancer 2 10.3 MSH2 MLH1
13 silent pituitary adenoma 10.3 MSH6 MSH2
14 mixed cell adenoma 10.2 ESR1 EGF
15 xanthogranulomatous pyelonephritis 10.2 SERPINA3 EGF
16 ascending colon cancer 10.2 MSH2 MLH1
17 breast malignant phyllodes tumor 10.2 SERPINA3 ESR1
18 lower lip cancer 10.2 MSH2 MLH1
19 spindle cell intraocular melanoma 10.2 PMS2 MLH1
20 apocrine adenocarcinoma 10.2 SERPINA3 ESR1
21 transverse colon cancer 10.2 PMS2 MLH1
22 lipid-rich carcinoma 10.2 PLIN2 ESR1
23 periampullary adenoma 10.2 PMS2 MSH6
24 endometrioid ovary carcinoma 10.2 MSH6 MLH1
25 heart cancer 10.2 TSC1 SERPINA3
26 colorectal cancer, hereditary nonpolyposis, type 4 10.2 PMS2 MLH1
27 intracranial meningioma 10.2 MSH2 MLH1 ESR1
28 esophageal tuberculosis 10.2 PMS2 MSH6
29 ovarian endometrial cancer 10.2 SERPINA3 ESR1
30 melanocytic nevus syndrome, congenital 10.1 MSH2 MLH1
31 anal fistula 10.1 MSH2 MLH1 EGF
32 endometrial adenocarcinoma 10.1 MLH1 ESR1 EGF
33 thoracic benign neoplasm 10.1 SERPINA3 ESR1 EGF
34 fallopian tube endometrioid adenocarcinoma 10.1 PMS2 MSH6
35 breast benign neoplasm 10.1 SERPINA3 ESR1 EGF
36 prostatic hypertrophy 10.1 SERPINA3 ESR1 EGF
37 uterine body mixed cancer 10.1 MSH6 MLH1 ESR1
38 renal pelvis transitional cell carcinoma 10.1 MSH6 MSH2 MLH1
39 perivascular tumor 10.1 TSC1 SERPINA3
40 pre-malignant neoplasm 10.1 SERPINA3 ESR1 EGF
41 autosomal dominant non-syndromic intellectual disability 8 10.1 MSH6 MSH2 MLH1
42 in situ carcinoma 10.1 SERPINA3 ESR1 EGF
43 legius syndrome 10.1 MSH6 MSH2
44 breast carcinoma in situ 10.1 SERPINA3 ESR1 EGF
45 bilateral breast cancer 10.1 MSH6 MLH1 ESR1
46 breast-ovarian cancer, familial 1 10.1 MSH6 MSH2 MLH1
47 cecum carcinoma 10.1 MSH6 MSH2 MLH1
48 ureter, cancer of 10.1 MSH2 MLH1
49 rectum signet ring adenocarcinoma 10.1 PMS2 MSH2 MLH1
50 tuberous sclerosis 10.1

Graphical network of the top 20 diseases related to Sebaceous Adenoma:



Diseases related to Sebaceous Adenoma

Symptoms & Phenotypes for Sebaceous Adenoma

MGI Mouse Phenotypes related to Sebaceous Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.93 ESR1 KRT15 LRIG1 MLH1 MSH2 MSH6
2 digestive/alimentary MP:0005381 9.92 EGF ESR1 KRT15 LRIG1 MLH1 MSH2
3 endocrine/exocrine gland MP:0005379 9.8 EGF ESR1 LRIG1 MLH1 PLIN2 PMS2
4 integument MP:0010771 9.61 EGF ESR1 LRIG1 MLH1 MSH2 MSH6
5 neoplasm MP:0002006 9.28 ESR1 LRIG1 MLH1 MSH2 MSH6 MUTYH

Drugs & Therapeutics for Sebaceous Adenoma

Search Clinical Trials , NIH Clinical Center for Sebaceous Adenoma

Genetic Tests for Sebaceous Adenoma

Anatomical Context for Sebaceous Adenoma

MalaCards organs/tissues related to Sebaceous Adenoma:

40
Skin, Breast, Colon, Ovary, Salivary Gland, Tongue, Heart

Publications for Sebaceous Adenoma

Articles related to Sebaceous Adenoma:

(show top 50) (show all 185)
# Title Authors PMID Year
1
Sebaceous Tumors of the Skin: A Study of 145 Lesions From 136 Patients Correlating Pathologic Features and DNA Mismatch Repair Staining Pattern. 61
33201015 2021
2
An updated review of the sebaceous gland and its role in health and diseases Part 2: Pathophysiological clinical disorders of sebaceous glands. 61
33571388 2021
3
A case of Muir-Torre syndrome with a keratoacanthoma and sebaceous neoplasms: Clinicopathological features and a speculation on the pathogenesis of cutaneous tumor type. 61
33523490 2021
4
Case for diagnosis. Verrucous plaque on the pubic region. 61
33288371 2021
5
An updated review of the sebaceous gland and its role in health and diseases Part 1: Embryology, evolution, structure, and function of sebaceous glands. 61
33354858 2021
6
Increased Lipid Accumulation under Hypoxia in SZ95 Human Sebocytes. 61
32088721 2021
7
Bioinformatics analysis of the microRNA-mRNA network in sebaceous gland carcinoma of the eyelid. 61
33179085 2021
8
Sebaceous Adenoma in a Patient With Visceral Malignancies. 61
31923095 2020
9
Muir-Torre Syndrome Associated Periocular Sebaceous Neoplasms: Screening Patterns in the Literature and in Clinical Practice. 61
33005611 2020
10
Villous Sebaceous Adenoma Arising from the Caruncular Surface Squamous Epithelium. 61
33005618 2020
11
Cytologic features of sebaceous, lymphadenoma, and sebaceous lymphadenocarcinoma: Differential diagnostic considerations. 61
31967730 2020
12
Update on the pathology, genetics and somatic landscape of sebaceous tumours. 61
31821583 2020
13
CDKN2A, CDK1, and CCNE1 overexpression in sebaceous gland carcinoma of eyelid. 61
31571090 2020
14
Loss of ZNF750 in ocular and cutaneous sebaceous carcinoma. 61
31148199 2019
15
Sebaceous adenoma in the setting of immunosuppression for kidney transplantation. 61
31508474 2019
16
Utility of Ber-EP4 and MOC-31 in Basaloid Skin Tumor Detection. 61
29629953 2019
17
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours. 61
31209701 2019
18
Multiple benign adnexal tumours: Anything but benign. 61
30671930 2019
19
Spatial analysis of p63, K5 and K7 defines two groups of progenitor cells that differentially contribute to the maintenance of normal sebaceous glands, extraocular sebaceous carcinoma and benign sebaceous tumors. 61
30663115 2019
20
Frequent TLE1 Expression in Cutaneous Neoplasms. 61
30608261 2019
21
Muir-Torre Syndrome: A Case Report in a Woman Without Personal Cancer History. 61
29933315 2019
22
An unusual case of tuberous sclerosis incidentally discovered in adulthood: case report and review of the literature. 61
30619624 2018
23
Sebaceous tumours: more than skin deep. 61
29247065 2018
24
Analysis of histologic follow-up and risk of malignancy for salivary gland neoplasm of uncertain malignant potential proposed by the Milan System for Reporting Salivary Gland Cytopathology. 61
29669190 2018
25
Evaluation of universal immunohistochemical screening of sebaceous neoplasms in a service setting. 61
29333623 2018
26
Electrochemotherapy with Bleomycin of Different types of Cutaneous Tumours in a Ferret (Mustela Putorius Furo). 61
29520211 2018
27
Evaluation and comparison of staining patterns of factor XIIIa (AC-1A1), adipophilin and GATA3 in sebaceous neoplasia. 61
28873247 2018
28
Desmoplastic Fibroma Recurrence Associated with Tuberous Sclerosis in a Young Patient. 61
29850273 2018
29
TdT expression in normal and neoplastic sebaceous cells. 61
28677299 2017
30
Sebaceous lesions of the skin. 61
29078997 2017
31
Intra-oral Sebaceous Gland Tumours in Two Dogs. 61
29169626 2017
32
Identification of MSH2 inversion of exons 1-7 in clinical evaluation of families with suspected Lynch syndrome. 61
28004223 2017
33
Sebaceous Neoplasms. 61
28477886 2017
34
Sebaceous adenoma arising in mature cystic teratoma of the ovary. Case report. 61
28248120 2017
35
A case report of Muir-Torre syndrome in a woman with breast cancer and MSI-Low skin squamous cell carcinoma. 61
28507641 2017
36
Cutaneous Sebaceous Lesions in a Patient With MUTYH-Associated Polyposis Mimicking Muir-Torre Syndrome. 61
27870730 2016
37
Clinicopathological study of 47 cases of sebaceoma. 61
27836252 2016
38
Circumscribed sebaceous neoplasms: a morphological, immunohistochemical and molecular analysis. 61
27311873 2016
39
Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a sensitive and specific marker to discriminate sebaceous proliferations from other cutaneous clear cell neoplasms. 61
27153339 2016
40
A unique case of isolated sebaceous adenoma of the bulbar conjunctiva. 61
27626151 2016
41
Epidermal CYLD inactivation sensitizes mice to the development of sebaceous and basaloid skin tumors. 61
27478875 2016
42
GATA3 Expression in Normal Skin and in Benign and Malignant Epidermal and Cutaneous Adnexal Neoplasms. 61
26595821 2015
43
Sebaceous Adenoma of the Caruncle. 61
26398052 2015
44
Distinct pathways in the pathogenesis of sebaceous carcinomas implicated by differentially expressed microRNAs. 61
26203913 2015
45
[The tip of the iceberg: multiple cutaneous sebaceous tumor in colon cancer. Muir-Torre syndrome--case report]. 61
26051134 2015
46
Sebaceous adenoma: clinics, dermatoscopy, and histopathology. 61
25311786 2015
47
The role of immunohistochemistry in the Muir-Torre Syndrome. 61
26312706 2015
48
Muir-Torre syndrome. 61
25427047 2014
49
Fine-needle aspiration cytomorphology of sebaceous lymphadenoma of the salivary gland. 61
24376220 2014
50
[Differential diagnostics of sebaceous tumors]. 61
25103328 2014

Variations for Sebaceous Adenoma

ClinVar genetic disease variations for Sebaceous Adenoma:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 TSC1 NM_000368.4(TSC1):c.658del (p.Val220fs) Deletion Likely pathogenic 374172 rs1057518945 GRCh37: 9:135797211-135797211
GRCh38: 9:132921824-132921824

Expression for Sebaceous Adenoma

Search GEO for disease gene expression data for Sebaceous Adenoma.

Pathways for Sebaceous Adenoma

Pathways related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 PMS2 MUTYH MSH6 MSH2 MLH1
2
Show member pathways
12.49 MSH6 MSH2 MLH1 EGF
3 12.44 MSH6 MSH2 MLH1 ESR1 EGF
4
Show member pathways
12.36 TSC1 MSH6 ESR1 EGF
5 12.18 MUTYH MSH6 MSH2 MLH1
6 11.78 MSH6 MSH2 MLH1 EGF
7 11.77 PMS2 MSH2 MLH1
8
Show member pathways
11.64 LRIG1 ESR1 EGF
9 11.64 TSC1 MSH6 MSH2 ESR1
10 11.41 MSH6 MSH2 MLH1
11
Show member pathways
11.23 PMS2 MSH6 MSH2 MLH1
12 10.39 PMS2 MSH6 MSH2 MLH1

GO Terms for Sebaceous Adenoma

Cellular components related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 9.16 PMS2 MLH1
2 MutSalpha complex GO:0032301 8.96 MSH6 MSH2
3 mismatch repair complex GO:0032300 8.92 PMS2 MSH6 MSH2 MLH1

Biological processes related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.88 PMS2 MUTYH MSH6 MSH2 MLH1
2 DNA repair GO:0006281 9.77 PMS2 MUTYH MSH6 MSH2 MLH1
3 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.58 MSH6 MSH2 MLH1
4 determination of adult lifespan GO:0008340 9.56 MSH6 MSH2
5 mammary gland alveolus development GO:0060749 9.55 ESR1 EGF
6 negative regulation of DNA recombination GO:0045910 9.54 MSH6 MSH2
7 protein localization to chromatin GO:0071168 9.52 MSH2 ESR1
8 positive regulation of isotype switching to IgG isotypes GO:0048304 9.51 MSH2 MLH1
9 positive regulation of helicase activity GO:0051096 9.49 MSH6 MSH2
10 positive regulation of isotype switching to IgA isotypes GO:0048298 9.46 MSH2 MLH1
11 maintenance of DNA repeat elements GO:0043570 9.43 MSH6 MSH2
12 isotype switching GO:0045190 9.43 MSH6 MSH2 MLH1
13 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MSH6 MSH2 MLH1
14 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MSH2 MLH1
15 somatic hypermutation of immunoglobulin genes GO:0016446 9.26 PMS2 MSH6 MSH2 MLH1
16 mismatch repair GO:0006298 9.02 PMS2 MUTYH MSH6 MSH2 MLH1

Molecular functions related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.81 MSH6 MSH2 MLH1 ESR1
2 enzyme binding GO:0019899 9.8 MSH6 MSH2 MLH1 ESR1
3 ATPase activity GO:0016887 9.73 PMS2 MSH6 MSH2 MLH1
4 single-stranded DNA binding GO:0003697 9.63 PMS2 MSH2 MLH1
5 MutSalpha complex binding GO:0032407 9.5 PMS2 MUTYH MLH1
6 four-way junction DNA binding GO:0000400 9.48 MSH6 MSH2
7 MutLalpha complex binding GO:0032405 9.43 MUTYH MSH6 MSH2
8 single guanine insertion binding GO:0032142 9.4 MSH6 MSH2
9 single thymine insertion binding GO:0032143 9.37 MSH6 MSH2
10 oxidized purine DNA binding GO:0032357 9.33 MUTYH MSH6 MSH2
11 guanine/thymine mispair binding GO:0032137 9.13 MSH6 MSH2 MLH1
12 mismatched DNA binding GO:0030983 8.92 PMS2 MSH6 MSH2 MLH1

Sources for Sebaceous Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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