MCID: SBC009
MIFTS: 36

Sebaceous Adenoma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Sebaceous Adenoma

MalaCards integrated aliases for Sebaceous Adenoma:

Name: Sebaceous Adenoma 12 15 72
Skin Appendage Sebaceous Adenoma 12
Adenoma of the Sebaceous Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2648
NCIt 50 C4174
SNOMED-CT 68 78424008
UMLS 72 C1368816

Summaries for Sebaceous Adenoma

MalaCards based summary : Sebaceous Adenoma, also known as skin appendage sebaceous adenoma, is related to keratoacanthoma and lynch syndrome. An important gene associated with Sebaceous Adenoma is MSH2 (MutS Homolog 2), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Endometrial cancer. Affiliated tissues include skin, salivary gland and colon, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and digestive/alimentary

Wikipedia : 75 A sebaceous adenoma, a type of adenoma, a cutaneous condition characterized by a slow-growing tumor... more...

Related Diseases for Sebaceous Adenoma

Diseases related to Sebaceous Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 keratoacanthoma 30.1 MSH2 MLH1
2 lynch syndrome 28.4 PMS2 MSH6 MSH2 MLH1
3 muir-torre syndrome 28.3 PMS2 PLIN2 MSH6 MSH2 MLH1
4 sebaceous adenocarcinoma 27.8 PMS2 PLIN2 MSH6 MSH2 MLH1
5 adenoma 10.9
6 prostatic hypertrophy 10.2 ESR1 EGF
7 estrogen-receptor negative breast cancer 10.2 ESR1 EGF
8 colorectal cancer, hereditary nonpolyposis, type 7 10.2 MSH2 MLH1
9 lower lip cancer 10.1 MSH2 MLH1
10 lipid-rich carcinoma 10.1 PLIN2 ESR1
11 melanocytic nevus syndrome, congenital 10.1 MSH2 MLH1
12 sebaceous gland disease 10.1 PLIN2 MSH2
13 childhood kidney cell carcinoma 10.1 MSH2 MLH1
14 tuberous sclerosis 10.0
15 cystic teratoma 10.0
16 teratoma 10.0
17 rare tumor 10.0
18 attenuated familial adenomatous polyposis 10.0 MSH6 MSH2
19 intestinal benign neoplasm 10.0 MSH2 MLH1
20 vitiligo-associated multiple autoimmune disease susceptibility 6 10.0
21 vitiligo-associated multiple autoimmune disease susceptibility 1 10.0
22 colorectal cancer 5 10.0 MSH6 MLH1
23 gastric leiomyoma 10.0 MSH6 MLH1
24 legius syndrome 10.0 MSH6 MSH2
25 familial colorectal cancer 9.9 MSH2 MLH1
26 reproductive system disease 9.9 MLH1 ESR1 EGF
27 leukemia, chronic lymphocytic 9.9
28 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.9
29 immune deficiency disease 9.9
30 gastrointestinal carcinoma 9.9
31 sialadenitis 9.9
32 lymphocytic leukemia 9.9
33 bacterial infectious disease 9.9
34 sialolithiasis 9.9
35 squamous cell papilloma 9.9
36 keratosis 9.9
37 squamous cell carcinoma 9.9
38 colon adenocarcinoma 9.9
39 papilloma 9.9
40 glioblastoma multiforme 9.9
41 pleomorphic adenoma 9.9
42 mucoepidermoid carcinoma 9.9
43 adenosquamous carcinoma 9.9
44 ovarian cystic teratoma 9.9
45 syringocystadenoma papilliferum 9.9
46 mature teratoma 9.9
47 sebaceous gland neoplasm 9.9
48 mature teratoma of the ovary 9.9
49 acquired immunodeficiency syndrome 9.9
50 follicular infundibulum tumor 9.9

Graphical network of the top 20 diseases related to Sebaceous Adenoma:



Diseases related to Sebaceous Adenoma

Symptoms & Phenotypes for Sebaceous Adenoma

GenomeRNAi Phenotypes related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.92 MLH1 MSH2 MSH6 PMS2

MGI Mouse Phenotypes related to Sebaceous Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.8 EGF ESR1 MLH1 MSH2 PMS2
2 homeostasis/metabolism MP:0005376 9.8 ESR1 MLH1 MSH2 MSH6 PLIN2 PMS2
3 immune system MP:0005387 9.8 EGF ESR1 MLH1 MSH2 MSH6 PLIN2
4 endocrine/exocrine gland MP:0005379 9.77 EGF ESR1 MLH1 PLIN2 PMS2
5 integument MP:0010771 9.63 EGF ESR1 MLH1 MSH2 MSH6 PLIN2
6 neoplasm MP:0002006 9.35 ESR1 MLH1 MSH2 MSH6 PMS2
7 reproductive system MP:0005389 9.02 EGF ESR1 MLH1 PLIN2 PMS2

Drugs & Therapeutics for Sebaceous Adenoma

Search Clinical Trials , NIH Clinical Center for Sebaceous Adenoma

Genetic Tests for Sebaceous Adenoma

Anatomical Context for Sebaceous Adenoma

MalaCards organs/tissues related to Sebaceous Adenoma:

41
Skin, Salivary Gland, Colon, Brain, Ovary, Kidney, Breast

Publications for Sebaceous Adenoma

Articles related to Sebaceous Adenoma:

(show top 50) (show all 169)
# Title Authors PMID Year
1
Multiple benign adnexal tumours: Anything but benign. 38
30671930 2019
2
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours. 38
31209701 2019
3
Loss of ZNF750 in ocular and cutaneous sebaceous carcinoma. 38
31148199 2019
4
Spatial analysis of p63, K5 and K7 defines two groups of progenitor cells that differentially contribute to the maintenance of normal sebaceous glands, extraocular sebaceous carcinoma and benign sebaceous tumors. 38
30663115 2019
5
Frequent TLE1 Expression in Cutaneous Neoplasms. 38
30608261 2019
6
Muir-Torre Syndrome: A Case Report in a Woman Without Personal Cancer History. 38
29933315 2019
7
An unusual case of tuberous sclerosis incidentally discovered in adulthood: case report and review of the literature. 38
30619624 2018
8
Sebaceous tumours: more than skin deep. 38
29247065 2018
9
Analysis of histologic follow-up and risk of malignancy for salivary gland neoplasm of uncertain malignant potential proposed by the Milan System for Reporting Salivary Gland Cytopathology. 38
29669190 2018
10
Evaluation of universal immunohistochemical screening of sebaceous neoplasms in a service setting. 38
29333623 2018
11
Utility of Ber-EP4 and MOC-31 in Basaloid Skin Tumor Detection. 38
29629953 2018
12
Electrochemotherapy with Bleomycin of Different types of Cutaneous Tumours in a Ferret (Mustela Putorius Furo). 38
29520211 2018
13
Desmoplastic Fibroma Recurrence Associated with Tuberous Sclerosis in a Young Patient. 38
29850273 2018
14
Evaluation and comparison of staining patterns of factor XIIIa (AC-1A1), adipophilin and GATA3 in sebaceous neoplasia. 38
28873247 2018
15
Sebaceous lesions of the skin. 38
29078997 2017
16
TdT expression in normal and neoplastic sebaceous cells. 38
28677299 2017
17
Intra-oral Sebaceous Gland Tumours in Two Dogs. 38
29169626 2017
18
Identification of MSH2 inversion of exons 1-7 in clinical evaluation of families with suspected Lynch syndrome. 38
28004223 2017
19
Sebaceous Neoplasms. 38
28477886 2017
20
A case report of Muir-Torre syndrome in a woman with breast cancer and MSI-Low skin squamous cell carcinoma. 38
28507641 2017
21
Sebaceous adenoma arising in mature cystic teratoma of the ovary. Case report. 38
28248120 2017
22
Clinicopathological study of 47 cases of sebaceoma. 38
27836252 2016
23
Cutaneous Sebaceous Lesions in a Patient With MUTYH-Associated Polyposis Mimicking Muir-Torre Syndrome. 38
27870730 2016
24
Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a sensitive and specific marker to discriminate sebaceous proliferations from other cutaneous clear cell neoplasms. 38
27153339 2016
25
Circumscribed sebaceous neoplasms: a morphological, immunohistochemical and molecular analysis. 38
27311873 2016
26
Epidermal CYLD inactivation sensitizes mice to the development of sebaceous and basaloid skin tumors. 38
27478875 2016
27
A unique case of isolated sebaceous adenoma of the bulbar conjunctiva. 38
27626151 2016
28
GATA3 Expression in Normal Skin and in Benign and Malignant Epidermal and Cutaneous Adnexal Neoplasms. 38
26595821 2015
29
Sebaceous Adenoma of the Caruncle. 38
26398052 2015
30
Distinct pathways in the pathogenesis of sebaceous carcinomas implicated by differentially expressed microRNAs. 38
26203913 2015
31
[The tip of the iceberg: multiple cutaneous sebaceous tumor in colon cancer. Muir-Torre syndrome--case report]. 38
26051134 2015
32
Sebaceous adenoma: clinics, dermatoscopy, and histopathology. 38
25311786 2015
33
The role of immunohistochemistry in the Muir-Torre Syndrome. 38
26312706 2015
34
Muir-Torre syndrome. 38
25427047 2014
35
Fine-needle aspiration cytomorphology of sebaceous lymphadenoma of the salivary gland. 38
24376220 2014
36
[Differential diagnostics of sebaceous tumors]. 38
25103328 2014
37
[Cutaneous adnexal and salivary gland tumours. Similarities and differences]. 38
25103327 2014
38
Preferential expression of OVOL1 in inner root sheath of hair, sebaceous gland, eccrine duct and their neoplasms in human skin. 38
25509883 2014
39
Corneal limbal sebaceous adenoma. 38
24556852 2014
40
Clear cell myoepithelioma of palate with emphasis on clinical and histological differential diagnosis. 38
24847433 2014
41
Androgen receptor identification in the diagnosis of eyelid sebaceous carcinomas. 38
24333189 2014
42
Synchronous gastric and sebaceous cancers, a rare manifestation of MLH1-related Muir-Torre syndrome. 38
25197397 2014
43
Tumours of the skin adnexa: a case series with focus on multiple segmental forms. 38
24730337 2013
44
Interobserver variability in the diagnosis of circumscribed sebaceous neoplasms of the skin. 38
24018813 2013
45
Muir-Torre syndrome in a haemodialysis patient. 38
27293570 2013
46
Clinical, dermoscopic and reflectance confocal microscopy features of sebaceous neoplasms in Muir-Torre syndrome. 38
22471909 2013
47
[Muir-Torre syndrome with previously undescribed frameshift mutation in the MSH2 gene]. 38
23229822 2013
48
Borderline sebaceous neoplasm in a renal transplant patient without Muir-Torre syndrome. 38
23174034 2013
49
The molecular genetics of eyelid tumors: recent advances and future directions. 38
23275038 2013
50
A case of sebaceous adenoma of the eyelid showing excessively rapid growth. 38
23579539 2013

Variations for Sebaceous Adenoma

Expression for Sebaceous Adenoma

Search GEO for disease gene expression data for Sebaceous Adenoma.

Pathways for Sebaceous Adenoma

Pathways related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 PMS2 MSH6 MSH2 MLH1
2
Show member pathways
12.45 MSH6 MSH2 MLH1 EGF
3
Show member pathways
12.41 MLH1 ESR1 EGF
4 12.38 MSH6 MSH2 MLH1 ESR1 EGF
5
Show member pathways
12.35 MSH6 ESR1 EGF
6
Show member pathways
12.34 MSH6 MSH2 ESR1
7 12.14 MSH6 MSH2 MLH1
8 11.8 MSH6 MSH2 ESR1
9 11.67 MSH6 MSH2 MLH1 EGF
10 11.66 PMS2 MSH2 MLH1
11
Show member pathways
11.5 MSH6 MSH2
12 11.37 ESR1 EGF
13 11.36 MSH6 MSH2 MLH1
14 11.23 MSH6 MSH2 MLH1
15
Show member pathways
11.23 PMS2 MSH6 MSH2 MLH1
16 11.19 MSH6 MSH2
17
Show member pathways
11.15 MSH2 MLH1
18
Show member pathways
11.08 MSH2 MLH1
19 10.39 PMS2 MSH6 MSH2 MLH1

GO Terms for Sebaceous Adenoma

Cellular components related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 9.16 PMS2 MLH1
2 MutSalpha complex GO:0032301 8.96 MSH6 MSH2
3 mismatch repair complex GO:0032300 8.92 PMS2 MSH6 MSH2 MLH1

Biological processes related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.84 PMS2 MSH6 MSH2 MLH1
2 DNA repair GO:0006281 9.78 PMS2 MSH6 MSH2 MLH1
3 negative regulation of DNA recombination GO:0045910 9.58 MSH6 MSH2
4 mammary gland alveolus development GO:0060749 9.57 ESR1 EGF
5 determination of adult lifespan GO:0008340 9.56 MSH6 MSH2
6 protein localization to chromatin GO:0071168 9.55 MSH2 ESR1
7 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.54 MSH6 MSH2 MLH1
8 positive regulation of isotype switching to IgG isotypes GO:0048304 9.52 MSH2 MLH1
9 positive regulation of helicase activity GO:0051096 9.51 MSH6 MSH2
10 positive regulation of isotype switching to IgA isotypes GO:0048298 9.46 MSH2 MLH1
11 maintenance of DNA repeat elements GO:0043570 9.43 MSH6 MSH2
12 isotype switching GO:0045190 9.43 MSH6 MSH2 MLH1
13 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MSH6 MSH2 MLH1
14 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MSH2 MLH1
15 interstrand cross-link repair GO:0036297 9.28 MSH6
16 mismatch repair GO:0006298 9.26 PMS2 MSH6 MSH2 MLH1
17 pyrimidine dimer repair GO:0006290 9.19 MSH6
18 meiotic mismatch repair GO:0000710 9.1 MSH6
19 somatic hypermutation of immunoglobulin genes GO:0016446 8.92 PMS2 MSH6 MSH2 MLH1

Molecular functions related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.8 MSH6 MSH2 MLH1 ESR1
2 enzyme binding GO:0019899 9.67 MSH6 MSH2 MLH1 ESR1
3 single-stranded DNA binding GO:0003697 9.65 PMS2 MSH2 MLH1
4 ATPase activity GO:0016887 9.56 PMS2 MSH6 MSH2 MLH1
5 damaged DNA binding GO:0003684 9.55 MSH6 MSH2
6 DNA-dependent ATPase activity GO:0008094 9.54 MSH6 MSH2
7 ADP binding GO:0043531 9.52 MSH6 MSH2
8 four-way junction DNA binding GO:0000400 9.51 MSH6 MSH2
9 oxidized purine DNA binding GO:0032357 9.46 MSH6 MSH2
10 MutSalpha complex binding GO:0032407 9.43 PMS2 MLH1
11 MutLalpha complex binding GO:0032405 9.4 MSH6 MSH2
12 single thymine insertion binding GO:0032143 9.32 MSH6 MSH2
13 single guanine insertion binding GO:0032142 9.16 MSH6 MSH2
14 guanine/thymine mispair binding GO:0032137 9.13 MSH6 MSH2 MLH1
15 mismatched DNA binding GO:0030983 8.92 PMS2 MSH6 MSH2 MLH1

Sources for Sebaceous Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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