MCID: SBC009
MIFTS: 37

Sebaceous Adenoma

Categories: Cancer diseases, Skin diseases, Endocrine diseases

Aliases & Classifications for Sebaceous Adenoma

MalaCards integrated aliases for Sebaceous Adenoma:

Name: Sebaceous Adenoma 12 15 73
Skin Appendage Sebaceous Adenoma 12
Adenoma of the Sebaceous Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2648
NCIt 50 C4174
SNOMED-CT 68 78424008
UMLS 73 C1368816

Summaries for Sebaceous Adenoma

MalaCards based summary : Sebaceous Adenoma, also known as skin appendage sebaceous adenoma, is related to muir-torre syndrome and colorectal cancer. An important gene associated with Sebaceous Adenoma is ESR1 (Estrogen Receptor 1), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Endometrial cancer. Affiliated tissues include skin, ovary and salivary gland, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and digestive/alimentary

Wikipedia : 76 A sebaceous adenoma, a type of adenoma, a cutaneous condition characterized by a slow-growing tumor... more...

Related Diseases for Sebaceous Adenoma

Diseases related to Sebaceous Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 muir-torre syndrome 28.0 MLH1 MSH2 MSH6 PMS2
2 colorectal cancer 26.3 EGF MLH1 MSH2 MSH6 PMS2
3 adenoma 10.6
4 prostatic hypertrophy 10.3 EGF ESR1
5 estrogen-receptor negative breast cancer 10.2 EGF ESR1
6 attenuated familial adenomatous polyposis 10.1 MSH2 MSH6
7 breast giant fibroadenoma 10.1 ESR1 PMS2
8 legius syndrome 10.1 MSH2 MSH6
9 cell type cancer 9.9 EGF ESR1
10 cystic teratoma 9.9
11 teratoma 9.9
12 insulin-like growth factor i 9.8 EGF ESR1
13 lower lip cancer 9.8 MLH1 MSH2
14 gastric leiomyoma 9.8 MLH1 MSH6
15 neurofibromatosis, type iv, of riccardi 9.8 MSH6 PMS2
16 melanocytic nevus syndrome, congenital 9.8 MLH1 MSH2
17 childhood kidney cell carcinoma 9.7 MLH1 MSH2
18 leukemia, chronic lymphocytic 2 9.7
19 glioma susceptibility 1 9.7
20 leukemia, chronic lymphocytic 9.7
21 leukemia 9.7
22 glioblastoma multiforme 9.7
23 adenosquamous carcinoma 9.7
24 syringocystadenoma papilliferum 9.7
25 conjunctivitis 9.7
26 acquired immunodeficiency syndrome 9.7
27 follicular infundibulum tumor 9.7
28 glioblastoma 9.7
29 leukemia, b-cell, chronic 9.7
30 endometrial adenocarcinoma 9.7 ESR1 MLH1
31 small intestine cancer 9.7 MLH1 MSH2
32 keratoacanthoma 9.7 MLH1 MSH2
33 intestinal benign neoplasm 9.7 MLH1 MSH2
34 familial colorectal cancer 9.6 MLH1 MSH2
35 colorectal adenoma 9.6 MLH1 MSH2
36 endocrine gland cancer 9.6 ESR1 MLH1
37 breast adenocarcinoma 9.6 EGF ESR1
38 hereditary breast ovarian cancer syndrome 9.6 MLH1 MSH2
39 rectal neoplasm 9.5 MLH1 MSH2
40 rhabdomyosarcoma 9.4 MSH2 MSH6 PMS2
41 anal fistula 9.3 EGF MLH1 MSH2
42 cecum adenocarcinoma 9.2 MLH1 MSH2 MSH6
43 skin benign neoplasm 9.2 MLH1 MSH2 MSH6
44 colorectal adenocarcinoma 9.2 MLH1 MSH2 MSH6
45 familial adenomatous polyposis 9.2 MLH1 MSH2 MSH6
46 adamantinoma of long bones 8.8 EGF ESR1 MLH1 MSH2
47 appendix carcinoid tumor 8.5 MLH1 MSH2 MSH6 PMS2
48 adenosquamous colon carcinoma 8.5 MLH1 MSH2 MSH6 PMS2
49 lynch syndrome i 8.5 MLH1 MSH2 MSH6 PMS2
50 sebaceous adenocarcinoma 8.5 MLH1 MSH2 MSH6 PMS2

Graphical network of the top 20 diseases related to Sebaceous Adenoma:



Diseases related to Sebaceous Adenoma

Symptoms & Phenotypes for Sebaceous Adenoma

GenomeRNAi Phenotypes related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.92 MLH1 MSH2 MSH6 PMS2

MGI Mouse Phenotypes related to Sebaceous Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.65 PMS2 EGF ESR1 MLH1 MSH2
2 immune system MP:0005387 9.55 MSH6 PMS2 EGF ESR1 MSH2
3 integument MP:0010771 9.35 EGF ESR1 MLH1 MSH2 MSH6
4 neoplasm MP:0002006 9.02 PMS2 ESR1 MLH1 MSH2 MSH6

Drugs & Therapeutics for Sebaceous Adenoma

Search Clinical Trials , NIH Clinical Center for Sebaceous Adenoma

Genetic Tests for Sebaceous Adenoma

Anatomical Context for Sebaceous Adenoma

MalaCards organs/tissues related to Sebaceous Adenoma:

41
Skin, Ovary, Salivary Gland

Publications for Sebaceous Adenoma

Articles related to Sebaceous Adenoma:

(show top 50) (show all 52)
# Title Authors Year
1
Sebaceous adenoma arising in mature cystic teratoma of the ovary. Case report. ( 28248120 )
2017
2
A unique case of isolated sebaceous adenoma of the bulbar conjunctiva. ( 27626151 )
2016
3
Sebaceous adenomas in the absence of Muir-Torre syndrome. ( 27769341 )
2016
4
Sebaceous Adenoma of the Caruncle. ( 26398052 )
2015
5
Sebaceous adenomas of the eyelid and Muir-Torre Syndrome. ( 25595178 )
2015
6
Corneal limbal sebaceous adenoma. ( 24556852 )
2014
7
Sebaceous adenoma: clinics, dermatoscopy, and histopathology. ( 25311786 )
2014
8
A case of sebaceous adenoma of the eyelid showing excessively rapid growth. ( 23579539 )
2013
9
Sebaceous adenoma arising within an ovarian mature cystic teratoma in Muir-Torre syndrome. ( 21684182 )
2012
10
Metachronous occurrence of colorectal cancer in a muir-torre syndrome patient presenting with recurrent sebaceous adenoma of the eyelid: case report and updated review of the literature. ( 23149194 )
2012
11
A rare case of sebaceous adenoma of the palate, with literature review. ( 21443818 )
2011
12
Treatment of sebaceous adenoma with topical photodynamic therapy. ( 20956668 )
2010
13
Mucoepidermoid (adenosquamous) carcinoma, trichoblastoma, trichilemmoma, sebaceous adenoma, tumor of follicular infundibulum and syringocystadenoma papilliferum arising within 2 persistent lesions of nevus sebaceous: report of a case. ( 19652586 )
2009
14
Sebaceous adenoma of the submandibular gland: a case report. ( 20032620 )
2009
15
Demodex-associated dermatologic conditions--A coincidence or an etiological correlate. Review with a report of a rare case of sebaceous adenoma. ( 19167837 )
2009
16
Comparative clinicopathological study of intraoral sebaceous hyperplasia and sebaceous adenoma. ( 19101492 )
2009
17
Sebaceous adenoma of the parotid gland: a case report with fine needle aspiration findings and histologic correlation. ( 19697727 )
2009
18
Sebaceous adenoma of the parotid gland in a 2-year-old male. ( 17418275 )
2007
19
Sebaceous adenoma of the bulbar conjunctiva in association with glioblastoma multiforme and chronic lymphocytic leukemia. ( 17893552 )
2007
20
Penile sebaceous adenoma. ( 17637371 )
2007
21
Sebaceous adenoma of the parotid gland. ( 16878064 )
2006
22
Sebaceous adenoma of the eyelid in Muir-Torre syndrome. ( 15824235 )
2005
23
Sebaceous adenoma of oral cavity: report of case and comparative proliferation study with sebaceous gland hyperplasia and Fordyce's granules. ( 14629335 )
2003
24
Sebaceous adenoma in the retromolar region: report of a case with a review of the English literature. ( 14505629 )
2003
25
Sebaceous adenoma in the submandibular gland. ( 11870356 )
2002
26
Loss of p21(WAF1) compartmentalisation in sebaceous carcinoma compared with sebaceous hyperplasia and sebaceous adenoma. ( 12354803 )
2002
27
Sebaceous adenoma of the cheek. ( 11755830 )
2002
28
Sebaceous adenomas with atypical immunohistochemical features in the Muir-Torre syndrome [leter]. ( 10233335 )
1999
29
Solitary facial lesion. Sebaceous adenoma in association with Muir-Torre syndrome (MTS). ( 9006382 )
1997
30
Sebaceous adenoma of the submandibular gland: a case report. ( 8863311 )
1996
31
Immunohistochemical study on sebaceous adenoma and sebaceous carcinoma arising in parotid gland. ( 21594425 )
1996
32
Sebaceous adenoma with a cutaneous horn. ( 7560356 )
1995
33
Sebaceous adenoma in the region of the medial canthus causing proptosis. ( 10707724 )
1995
34
CT of sebaceous adenoma of the parotid gland. ( 7976936 )
1994
35
Sebaceous adenoma of parotid gland--a rare tumour diagnosed by fine needle aspiration cytology. ( 7880973 )
1994
36
Sebaceous adenoma in a patient with acquired immunodeficiency syndrome. ( 3355190 )
1988
37
Sebaceous adenoma of the oral mucosa. ( 3469349 )
1987
38
Pathology quiz case 1: Sebaceous adenoma. ( 6849571 )
1983
39
Sebaceous adenoma of the oral cavity. ( 6571741 )
1983
40
Tissue connections in a transplantable virus-producing sebaceous adenoma of the mouse. II. A freeze-fracture study in conjunction with filipin. ( 6277960 )
1982
41
Tissue connections in a transplantable virus-producing sebaceous adenoma of the mouse. ( 7338533 )
1981
42
Sebaceous adenoma of the eyelid and visceral malignancy. ( 4440729 )
1974
43
A SEBACEOUS ADENOMA. HISTOLOGICAL AND CHEMICAL STUDIES. ( 14183145 )
1964
44
Sebaceous adenoma of the submaxillary salivary gland. Report of a case. ( 14011757 )
1963
45
A REVIEW ON SEBACEOUS ADENOMA WITH REPORT OF A CASE IN THE EXTERNAL AUDITORY MEATUS. ( 14082064 )
1963
46
Sebaceous adenoma in a dog. ( 13407925 )
1957
47
Scalp: sebaceous adenoma. ( 13094140 )
1953
48
Diethylstilbestrol in the treatment of senile sebaceous adenoma. ( 14952023 )
1952
49
Sebaceous adenoma; review of the literature and report of a case. ( 18919779 )
1948
50
Senile Sebaceous Adenoma. ( 19991727 )
1938

Variations for Sebaceous Adenoma

Expression for Sebaceous Adenoma

Search GEO for disease gene expression data for Sebaceous Adenoma.

Pathways for Sebaceous Adenoma

Pathways related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 MLH1 MSH2 MSH6 PMS2
2
Show member pathways
12.45 EGF MLH1 MSH2 MSH6
3
Show member pathways
12.41 EGF ESR1 MSH6
4
Show member pathways
12.4 EGF ESR1 MLH1
5
Show member pathways
12.33 ESR1 MSH2 MSH6
6 12.27 EGF ESR1 MLH1 MSH2 MSH6
7 12.1 MLH1 MSH2 MSH6
8 11.8 ESR1 MSH2 MSH6
9 11.78 EGF MLH1 MSH2 MSH6
10 11.66 MLH1 MSH2 PMS2
11
Show member pathways
11.62 EGF ESR1
12 11.56 MLH1 PMS2
13
Show member pathways
11.49 MSH2 MSH6
14 11.36 EGF ESR1
15 11.36 MLH1 MSH2 MSH6
16
Show member pathways
11.25 MLH1 MSH2 MSH6 PMS2
17 11.19 MSH2 MSH6
18
Show member pathways
11.15 MLH1 MSH2
19
Show member pathways
11.1 MLH1 MSH2
20 10.39 MLH1 MSH2 MSH6 PMS2

GO Terms for Sebaceous Adenoma

Cellular components related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.65 ESR1 MLH1 MSH2 MSH6 PMS2
2 MutLalpha complex GO:0032389 9.16 MLH1 PMS2
3 MutSalpha complex GO:0032301 8.96 MSH2 MSH6
4 mismatch repair complex GO:0032300 8.92 MLH1 MSH2 MSH6 PMS2

Biological processes related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.83 MLH1 MSH2 MSH6 PMS2
2 DNA repair GO:0006281 9.78 MLH1 MSH2 MSH6 PMS2
3 male gonad development GO:0008584 9.58 ESR1 MSH2
4 phosphatidylinositol phosphorylation GO:0046854 9.57 EGF ESR1
5 mammary gland alveolus development GO:0060749 9.56 EGF ESR1
6 determination of adult lifespan GO:0008340 9.55 MSH2 MSH6
7 positive regulation of isotype switching to IgG isotypes GO:0048304 9.54 MLH1 MSH2
8 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.54 MLH1 MSH2 MSH6
9 positive regulation of helicase activity GO:0051096 9.51 MSH2 MSH6
10 negative regulation of DNA recombination GO:0045910 9.49 MSH2 MSH6
11 maintenance of DNA repeat elements GO:0043570 9.46 MSH2 MSH6
12 positive regulation of isotype switching to IgA isotypes GO:0048298 9.43 MLH1 MSH2
13 isotype switching GO:0045190 9.43 MLH1 MSH2 MSH6
14 meiotic mismatch repair GO:0000710 9.4 MSH2 MSH6
15 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MLH1 MSH2 MSH6
16 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MLH1 MSH2
17 mismatch repair GO:0006298 9.26 MLH1 MSH2 MSH6 PMS2
18 somatic hypermutation of immunoglobulin genes GO:0016446 8.92 MLH1 MSH2 MSH6 PMS2

Molecular functions related to Sebaceous Adenoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.87 MLH1 MSH2 MSH6 PMS2
2 chromatin binding GO:0003682 9.72 ESR1 MLH1 MSH6
3 single-stranded DNA binding GO:0003697 9.65 MLH1 MSH2 PMS2
4 ATPase activity GO:0016887 9.62 MLH1 MSH2 MSH6 PMS2
5 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.56 EGF ESR1
6 damaged DNA binding GO:0003684 9.54 MSH2 MSH6
7 DNA-dependent ATPase activity GO:0008094 9.52 MSH2 MSH6
8 ADP binding GO:0043531 9.51 MSH2 MSH6
9 four-way junction DNA binding GO:0000400 9.49 MSH2 MSH6
10 oxidized purine DNA binding GO:0032357 9.46 MSH2 MSH6
11 MutLalpha complex binding GO:0032405 9.43 MSH2 MSH6
12 MutSalpha complex binding GO:0032407 9.4 MLH1 PMS2
13 single guanine insertion binding GO:0032142 9.37 MSH2 MSH6
14 guanine/thymine mispair binding GO:0032137 9.33 MLH1 MSH2 MSH6
15 single thymine insertion binding GO:0032143 9.26 MSH2 MSH6
16 single base insertion or deletion binding GO:0032138 9.13 MSH2 MSH6 PMS2
17 mismatched DNA binding GO:0030983 8.92 MLH1 MSH2 MSH6 PMS2

Sources for Sebaceous Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....