MCID: SBC017
MIFTS: 42

Sebaceous Gland Disease

Categories: Endocrine diseases, Rare diseases, Skin diseases

Aliases & Classifications for Sebaceous Gland Disease

MalaCards integrated aliases for Sebaceous Gland Disease:

Name: Sebaceous Gland Disease 12 15 17
Sebaceous Gland Diseases 70
Sebaceous Gland Anomaly 58

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:9098
ICD9CM 34 706.1
SNOMED-CT 67 201213005
ICD10 32 L70.8
Orphanet 58 ORPHA79372
UMLS 70 C0029485 C0036502

Summaries for Sebaceous Gland Disease

Disease Ontology : 12 A skin disease that is located in the sebaceous gland.

MalaCards based summary : Sebaceous Gland Disease, also known as sebaceous gland diseases, is related to acne and genetic sebaceous gland anomaly, and has symptoms including pruritus and exanthema. An important gene associated with Sebaceous Gland Disease is SHBG (Sex Hormone Binding Globulin), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. Affiliated tissues include sebaceous gland, pituitary and bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 73 A sebaceous gland is a microscopic exocrine gland in the skin that opens into a hair follicle to secrete... more...

Related Diseases for Sebaceous Gland Disease

Diseases related to Sebaceous Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 710)
# Related Disease Score Top Affiliating Genes
1 acne 30.9 TNF TLR2 SHBG PSTPIP1 PRL POMC
2 genetic sebaceous gland anomaly 11.3
3 steatocystoma multiplex 11.1
4 mycobacterium chelonae 10.5 TLR2 CXCL8
5 external pathological resorption 10.5 TNF IL6
6 psoriatic juvenile idiopathic arthritis 10.5 PSTPIP1 MEFV
7 scorpion envenomation 10.5 TNF IL6
8 mycobacterium marinum 10.5 TLR2 CXCL8
9 secondary adrenal insufficiency 10.5 INS IGF1
10 adenohypophysitis 10.5 PRL POMC
11 tuberculum sellae meningioma 10.5 PRL POMC
12 prostate adenoid cystic carcinoma 10.5 POMC AR
13 graves disease 1 10.5 SHBG POMC INS
14 sella turcica neoplasm 10.5 PRL POMC
15 staphylococcal toxic shock syndrome 10.5 TNF IL1B
16 aspiration pneumonitis 10.5 TNF SERPINA3 CXCL8
17 wells syndrome 10.5 MEFV IL1B CXCL8
18 enterocolitis 10.5 TNF IL6 CXCL8
19 conjunctivitis 10.5 TNF IL6 CXCL8
20 pasteurellosis 10.5 TNF SERPINA3 CXCL8
21 galactorrhea 10.5 PRL IGF1
22 marasmus 10.5 SHBG INS IGF1
23 haemophilus meningitis 10.5 TNF SHBG IL1B
24 benign essential hypertension 10.5 PRL POMC INS
25 haemophilus influenzae 10.5 TNF TLR2 CXCL8
26 hypothalamic disease 10.5 PRL POMC INS
27 mycobacterium kansasii 10.5 TLR2 CXCL8
28 mycobacterium abscessus 10.5 TNF TLR2 CXCL8
29 hypothalamic obesity 10.5 INS IGF1
30 tungiasis 10.5 TNF IL1B CXCL8
31 physiological polycythemia 10.5 TNF IL6 IL1B
32 congenital cytomegalovirus 10.5 TNF TLR2 IL1B
33 atypical depressive disorder 10.5 SERPINA3 POMC IL6
34 tuberculous meningitis 10.5 TNF TLR2 CXCL8
35 idiopathic anterior uveitis 10.5 TNF IL6 CXCL8
36 leukoregulin 10.5 IL1A CXCL8
37 streptococcal toxic-shock syndrome 10.5 TNF IL6 CXCL8
38 diabetic encephalopathy 10.5 INS IL1B IGF1
39 cardiac sarcoidosis 10.5 TNF IL1B CXCL8
40 hormone producing pituitary cancer 10.5 PRL POMC IGF1
41 acute stress disorder 10.5 SERPINA3 POMC IL6
42 pigmentation disease 10.5 SHBG INS IGF1
43 acute transverse myelitis 10.5 IL6 CXCL8
44 combat disorder 10.5 TNF SERPINA3 IL6
45 acute adrenal insufficiency 10.5 POMC IL6 CYP21A2
46 toxicodendron dermatitis 10.5 TNF CXCL8
47 prosthetic joint infection 10.5 TLR2 IL6 IL1B
48 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 TNF IL6
49 ulcer of lower limbs 10.5 TNF IL6 IL1B
50 suppurative periapical periodontitis 10.5 IL6 IL1B CXCL8

Graphical network of the top 20 diseases related to Sebaceous Gland Disease:



Diseases related to Sebaceous Gland Disease

Symptoms & Phenotypes for Sebaceous Gland Disease

UMLS symptoms related to Sebaceous Gland Disease:


pruritus; exanthema

MGI Mouse Phenotypes related to Sebaceous Gland Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.24 AR CCR6 CYP21A2 IGF1 IL1A IL1B
2 homeostasis/metabolism MP:0005376 10.17 AR CCR6 IGF1 IL1A IL1B IL6
3 immune system MP:0005387 10.16 AR CCR6 CYP21A2 IGF1 IL1A IL1B
4 integument MP:0010771 10.03 AR CYP21A2 IGF1 IL1A IL1B IL6
5 adipose tissue MP:0005375 10.01 AR IGF1 IL6 INS PLIN2 POMC
6 liver/biliary system MP:0005370 9.61 AR IL6 INS MEFV PLIN2 POMC
7 neoplasm MP:0002006 9.32 AR IGF1 IL1A IL1B IL6 NCSTN

Drugs & Therapeutics for Sebaceous Gland Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optical Clearing of the Skin in Conjunction With Laser Treatments Completed NCT00580736 Phase 1
2 A Multicenter Randomized, Double-Masked Study Comparing the Efficacy of Novabay iLid Cleanser Versus Vehicle on Ocular Skin Flora Unknown status NCT02455895

Search NIH Clinical Center for Sebaceous Gland Disease

Genetic Tests for Sebaceous Gland Disease

Anatomical Context for Sebaceous Gland Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Sebaceous Gland Disease:

19
Sebaceous Gland

MalaCards organs/tissues related to Sebaceous Gland Disease:

40
Pituitary, Bone, Skin, Liver, Heart, Breast, Eye

Publications for Sebaceous Gland Disease

Articles related to Sebaceous Gland Disease:

# Title Authors PMID Year
1
Establishment and characterization of a canine sebaceous epithelial cell line derived from an eyelid mass. 61
32921644 2020
2
Combination of metformin and berberine represses the apoptosis of sebocytes in high-fat diet-induced diabetic hamsters and an insulin-treated human cell line. 61
32080865 2020
3
Primary sebocytes and sebaceous gland cell lines for studying sebaceous lipogenesis and sebaceous gland diseases. 61
29451719 2018
4
High prevalence of skin diseases and need for treatment in a middle-aged population. A Northern Finland Birth Cohort 1966 study. 61
24911008 2014
5
New pharmaceutical concepts for sebaceous gland diseases: implementing today's pre-clinical data into tomorrow's daily clinical practice. 61
22250709 2012
6
[Ectoparasites. Part 2: Bed bugs, Demodex, sand fleas and cutaneous larva migrans]. 61
19701614 2009
7
Risk factors for sebaceous gland diseases and their relationship to gastrointestinal dysfunction in Han adolescents. 61
18837699 2008
8
A study of skin diseases in Tunis. An analysis of 28,244 dermatological outpatient cases. 61
17994171 2007

Variations for Sebaceous Gland Disease

Expression for Sebaceous Gland Disease

Search GEO for disease gene expression data for Sebaceous Gland Disease.

Pathways for Sebaceous Gland Disease

Pathways related to Sebaceous Gland Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 TNF TLR2 SIGLEC5 SERPINA3 PSTPIP1 PRL
2
Show member pathways
13.57 TNF PRL INS IL6 IL1B IL1A
3
Show member pathways
13.45 TNF TLR2 IL6 IL1B IL1A IGF1
4
Show member pathways
13.38 TNF PRL POMC IL6 IL1B IL1A
5
Show member pathways
13.33 TNF IL6 IL1B IL1A IGF1 CXCL8
6
Show member pathways
13.02 TNF TLR2 PRL INS IL6 IGF1
7
Show member pathways
12.9 TNF INS IL6 IL1B IL1A CXCL8
8
Show member pathways
12.87 TNF TLR2 IL6 IL1B IL1A CXCL8
9 12.79 TNF INS IL1B IL1A IGF1
10
Show member pathways
12.77 TNF TLR2 IL6 IL1B CXCL8
11
Show member pathways
12.76 TNF TLR2 IL6 IL1B IL1A IGF1
12
Show member pathways
12.64 TNF TLR2 PSTPIP1 IL6 IL1B IL1A
13
Show member pathways
12.63 TNF TLR2 IL6 IL1B IL1A
14
Show member pathways
12.48 TNF TLR2 IL6 IL1B CXCL8
15
Show member pathways
12.4 TNF SERPINA3 INS IL6 IL1B
16
Show member pathways
12.4 TNF TLR2 IL6 IL1B CXCL8
17
Show member pathways
12.37 TNF IL6 IL1B IL1A CXCL8
18
Show member pathways
12.36 TNF IL6 CXCL8 CCR6
19
Show member pathways
12.31 TNF TLR2 IL6 IL1A CXCL8
20
Show member pathways
12.3 TNF IL6 IL1B IL1A IGF1 CXCL8
21
Show member pathways
12.29 TNF TLR2 IL1B IL1A
22 12.28 TNF TLR2 IL6 IL1B IL1A
23 12.27 TNF PSTPIP1 MEFV IL6 IL1B CXCL8
24
Show member pathways
12.25 TNF TLR2 IL6 IL1B IL1A CXCL8
25
Show member pathways
12.22 TNF TLR2 IL6 IL1B CXCL8
26 12.16 TNF IL6 IL1B IL1A CXCL8 AR
27 12.13 TNF MEFV IL6 IL1B CXCL8
28 12.11 TNF PLIN2 INS IL6 IGF1
29 12.06 TNF IL6 IL1B IL1A CXCL8
30 11.97 TNF IL6 IL1B IL1A
31 11.97 TNF TLR2 IL6 IL1B CXCL8
32 11.96 TNF IL6 IL1B IL1A CXCL8
33 11.87 PRL POMC IL6 CXCL8
34
Show member pathways
11.82 TNF TLR2 IL6 IL1B
35 11.81 TNF IL1B CCR6
36 11.79 TNF IL6 IL1B IL1A CXCL8
37 11.79 TNF POMC IL6 IL1B IL1A CXCL8
38 11.77 TNF IL6 IL1B
39 11.74 TNF TLR2 IL6 CCR6
40 11.66 INS IL6 IL1B IL1A IGF1 CXCL8
41
Show member pathways
11.65 TNF IL6 IL1B IL1A CXCL8
42 11.63 INS IL6 CXCL8
43 11.63 TNF IL6 IL1B IGF1 CXCL8
44 11.56 TNF TLR2 IL1B
45 11.56 IL6 IL1B IL1A
46 11.56 INS IL6 IGF1
47 11.56 TNF TLR2 IL6 IL1B CXCL8
48 11.47 TNF TLR2 IL6 IL1B CXCL8
49 11.44 TNF IL6 IL1B
50 11.42 TNF IL6 IL1B IL1A

GO Terms for Sebaceous Gland Disease

Cellular components related to Sebaceous Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 TNF SERPINA3 PRL POMC INS IL6
2 extracellular region GO:0005576 9.4 TNF SHBG SERPINA3 PRL POMC PLIN2

Biological processes related to Sebaceous Gland Disease according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.21 TNF TLR2 POMC IL6 IL1A IGF1
2 signal transduction GO:0007165 10.17 TLR2 PSTPIP1 PRL POMC INS IL6
3 positive regulation of cell proliferation GO:0008284 10.1 PRL INS IL6 IL1B IGF1 AR
4 negative regulation of cell proliferation GO:0008285 10.03 TLR2 IL6 IL1B IL1A CXCL8 AR
5 cell-cell signaling GO:0007267 9.98 POMC INS IL1B AR
6 cellular protein metabolic process GO:0044267 9.95 PRL NCSTN INS IL6 IGF1
7 immune response GO:0006955 9.95 TNF TLR2 IL6 IL1B IL1A CXCL8
8 cytokine-mediated signaling pathway GO:0019221 9.93 TNF POMC IL6 IL1B IL1A CXCL8
9 cellular response to lipopolysaccharide GO:0071222 9.91 TNF IL6 IL1B IL1A CXCL8
10 positive regulation of MAPK cascade GO:0043410 9.88 INS IL6 IGF1 AR
11 regulation of insulin secretion GO:0050796 9.85 TNF IL6 IL1B
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 TNF IL6 IGF1
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 TNF TLR2 IL1B
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.84 TNF IL6 IGF1
15 humoral immune response GO:0006959 9.83 TNF IL6 CCR6
16 positive regulation of cytokine production GO:0001819 9.83 TNF INS IL1A
17 protein kinase B signaling GO:0043491 9.81 TNF IL1B IGF1
18 positive regulation of chemokine production GO:0032722 9.81 TNF TLR2 IL6
19 acute-phase response GO:0006953 9.8 SERPINA3 INS IL6
20 positive regulation of interleukin-8 production GO:0032757 9.8 TNF TLR2 IL6 IL1B
21 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.79 TNF IL1B IL1A
22 positive regulation of JAK-STAT cascade GO:0046427 9.77 TNF PRL IL6
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 TNF TLR2 IL1B
24 positive regulation of vascular endothelial growth factor production GO:0010575 9.75 IL6 IL1B IL1A
25 negative regulation of neurogenesis GO:0050768 9.74 TNF IL6 IL1B
26 positive regulation of interleukin-6 production GO:0032755 9.72 TNF TLR2 IL6 IL1B IL1A
27 positive regulation of glial cell proliferation GO:0060252 9.71 TNF IL6 IL1B
28 negative regulation of lipid catabolic process GO:0050995 9.7 TNF INS IL1B
29 regulation of establishment of endothelial barrier GO:1903140 9.68 TNF IL1B
30 negative regulation of lipid storage GO:0010888 9.67 TNF IL6
31 positive regulation of fever generation GO:0031622 9.65 TNF IL1B
32 positive regulation of immature T cell proliferation in thymus GO:0033092 9.65 IL1B IL1A
33 positive regulation of neuroinflammatory response GO:0150078 9.65 TNF IL6 IL1B
34 sequestering of triglyceride GO:0030730 9.64 TNF IL1B
35 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.63 TNF TLR2 INS IL6 IL1B AR
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 TNF IL1B
37 fever generation GO:0001660 9.61 IL1B IL1A
38 positive regulation of gene expression GO:0010628 9.61 TNF TLR2 INS IL6 IL1B IL1A
39 positive regulation of mitotic nuclear division GO:0045840 9.56 INS IL1B IL1A IGF1
40 vascular endothelial growth factor production GO:0010573 9.54 TNF IL6 IL1B
41 inflammatory response GO:0006954 9.28 TNF TLR2 SERPINA3 PSTPIP1 MEFV IL6

Molecular functions related to Sebaceous Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.46 PRL POMC INS IGF1
2 androgen binding GO:0005497 9.26 SHBG AR
3 steroid binding GO:0005496 9.13 SHBG CYP21A2 AR
4 cytokine activity GO:0005125 9.02 TNF IL6 IL1B IL1A CXCL8

Sources for Sebaceous Gland Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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