MCID: SBC017
MIFTS: 40

Sebaceous Gland Disease

Categories: Endocrine diseases, Rare diseases, Skin diseases

Aliases & Classifications for Sebaceous Gland Disease

MalaCards integrated aliases for Sebaceous Gland Disease:

Name: Sebaceous Gland Disease 12 15 17
Sebaceous Gland Diseases 71
Sebaceous Gland Anomaly 58

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:9098
ICD9CM 34 706.1
ICD10 32 L70.8
Orphanet 58 ORPHA79372
UMLS 71 C0029485 C0036502

Summaries for Sebaceous Gland Disease

Disease Ontology : 12 A skin disease that is located in the sebaceous gland.

MalaCards based summary : Sebaceous Gland Disease, also known as sebaceous gland diseases, is related to neurofibromatosis, type ii and alopecia, androgenetic, 1, and has symptoms including pruritus and exanthema. An important gene associated with Sebaceous Gland Disease is SHBG (Sex Hormone Binding Globulin), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include sebaceous gland and skin, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 74 A sebaceous gland is a microscopic exocrine gland in the skin that opens into a hair follicle to secrete... more...

Related Diseases for Sebaceous Gland Disease

Diseases related to Sebaceous Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 676)
# Related Disease Score Top Affiliating Genes
1 neurofibromatosis, type ii 33.2 TLR2 SHBG IL6 IL1A
2 alopecia, androgenetic, 1 30.8 SHBG CYP21A2 AR
3 seborrheic dermatitis 30.7 TNF SHBG IL1A CCR6
4 alopecia 30.6 TNF SHBG PRL IL1B IGF1 AR
5 androgenic alopecia 30.6 SHBG PRL INS IGF1 AR
6 rosacea 30.5 TNF TLR2 IL6 CXCL8 CCR6
7 skin disease 30.0 TNF TLR2 SIGLEC5 SERPINA3 IL6 IL1B
8 genetic sebaceous gland anomaly 12.5
9 steatocystoma multiplex 11.3
10 physiological polycythemia 10.7 TNF IL1B
11 mycobacterium chelonae 10.7 TLR2 CXCL8
12 external pathological resorption 10.7 TNF IL6
13 psoriatic juvenile idiopathic arthritis 10.7 PSTPIP1 MEFV
14 systemic onset juvenile idiopathic arthritis 10.7 TNF IL1B
15 mycobacterium marinum 10.7 TLR2 CXCL8
16 secondary adrenal insufficiency 10.7 INS IGF1
17 inhibited female orgasm 10.7 SHBG PRL
18 scorpion envenomation 10.7 TNF IL6
19 prostate adenoid cystic carcinoma 10.7 POMC AR
20 aspiration pneumonitis 10.7 TNF SERPINA3 CXCL8
21 adenohypophysitis 10.7 PRL POMC
22 wells syndrome 10.7 MEFV IL1B CXCL8
23 graves disease 1 10.7 SHBG POMC INS
24 staphylococcal toxic shock syndrome 10.7 TNF IL1B
25 haemophilus influenzae 10.7 TNF TLR2 CXCL8
26 galactorrhea 10.7 PRL IGF1
27 marasmus 10.7 SHBG INS IGF1
28 conjunctivitis 10.7 TNF IL6 CXCL8
29 mycobacterium abscessus 10.7 TNF TLR2 CXCL8
30 hypothalamic disease 10.7 PRL POMC INS
31 bacterial conjunctivitis 10.7 SIGLEC5 IL1B CXCL8
32 congenital cytomegalovirus 10.7 TNF TLR2 IL1B
33 mycobacterium kansasii 10.7 TLR2 CXCL8
34 aromatase excess syndrome 10.6 SHBG POMC IGF1
35 trichuriasis 10.6 TNF SERPINA3 CXCL8
36 hypothalamic obesity 10.6 INS IGF1
37 bagassosis 10.6 IL1B CXCL8
38 tuberculous meningitis 10.6 TNF TLR2 CXCL8
39 prostatic hyperplasia, benign 10.6 SHBG SERPINA3 AR
40 hormone producing pituitary cancer 10.6 PRL POMC IGF1
41 idiopathic anterior uveitis 10.6 TNF IL6 CXCL8
42 melancholia 10.6 TNF PRL POMC
43 atypical depressive disorder 10.6 SERPINA3 POMC IL6
44 streptococcal toxic-shock syndrome 10.6 TNF IL6 CXCL8
45 leukoregulin 10.6 IL1A CXCL8
46 diabetic encephalopathy 10.6 INS IL1B IGF1
47 cardiac sarcoidosis 10.6 TNF IL1B CXCL8
48 acute adrenal insufficiency 10.6 POMC IL6 CYP21A2
49 diabetes insipidus 10.6 PRL POMC INS
50 prosthetic joint infection 10.6 TLR2 IL6 IL1B

Graphical network of the top 20 diseases related to Sebaceous Gland Disease:



Diseases related to Sebaceous Gland Disease

Symptoms & Phenotypes for Sebaceous Gland Disease

UMLS symptoms related to Sebaceous Gland Disease:


pruritus, exanthema

MGI Mouse Phenotypes related to Sebaceous Gland Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 AR CCR6 CYP21A2 IGF1 IL1A IL1B
2 homeostasis/metabolism MP:0005376 10.2 AMH AR CCR6 IGF1 IL1A IL1B
3 cardiovascular system MP:0005385 10.13 AR CCR6 IGF1 IL1A IL1B IL6
4 immune system MP:0005387 10.13 AR CCR6 CYP21A2 IGF1 IL1A IL1B
5 endocrine/exocrine gland MP:0005379 10.1 AMH AR IGF1 IL6 INS PLIN2
6 adipose tissue MP:0005375 10.06 AR IGF1 IL6 INS PLIN2 POMC
7 integument MP:0010771 10 AR CYP21A2 IGF1 IL1A IL1B IL6
8 liver/biliary system MP:0005370 9.61 AR IL6 INS MEFV PLIN2 POMC
9 neoplasm MP:0002006 9.32 AMH AR IGF1 IL1A IL1B IL6

Drugs & Therapeutics for Sebaceous Gland Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optical Clearing of the Skin in Conjunction With Laser Treatments Completed NCT00580736 Phase 1
2 A Multicenter Randomized, Double-Masked Study Comparing the Efficacy of Novabay iLid Cleanser Versus Vehicle on Ocular Skin Flora Unknown status NCT02455895

Search NIH Clinical Center for Sebaceous Gland Disease

Genetic Tests for Sebaceous Gland Disease

Anatomical Context for Sebaceous Gland Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Sebaceous Gland Disease:

19
Sebaceous Gland

MalaCards organs/tissues related to Sebaceous Gland Disease:

40
Skin

Publications for Sebaceous Gland Disease

Articles related to Sebaceous Gland Disease:

# Title Authors PMID Year
1
Combination of metformin and berberine represses the apoptosis of sebocytes in high-fat diet-induced diabetic hamsters and an insulin-treated human cell line. 61
32080865 2020
2
Primary sebocytes and sebaceous gland cell lines for studying sebaceous lipogenesis and sebaceous gland diseases. 61
29451719 2018
3
High prevalence of skin diseases and need for treatment in a middle-aged population. A Northern Finland Birth Cohort 1966 study. 61
24911008 2014
4
New pharmaceutical concepts for sebaceous gland diseases: implementing today's pre-clinical data into tomorrow's daily clinical practice. 61
22250709 2012
5
[Ectoparasites. Part 2: Bed bugs, Demodex, sand fleas and cutaneous larva migrans]. 61
19701614 2009
6
Risk factors for sebaceous gland diseases and their relationship to gastrointestinal dysfunction in Han adolescents. 61
18837699 2008
7
A study of skin diseases in Tunis. An analysis of 28,244 dermatological outpatient cases. 61
17994171 2007

Variations for Sebaceous Gland Disease

Expression for Sebaceous Gland Disease

Search GEO for disease gene expression data for Sebaceous Gland Disease.

Pathways for Sebaceous Gland Disease

Pathways related to Sebaceous Gland Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 TNF TLR2 SIGLEC5 SERPINA3 PSTPIP1 PRL
2
Show member pathways
13.71 TNF PRL INS IL6 IL1B IL1A
3
Show member pathways
13.57 TNF PRL INS IL6 IL1B IL1A
4
Show member pathways
13.43 TNF TLR2 IL6 IL1B IL1A IGF1
5
Show member pathways
13.38 TNF PRL POMC IL6 IL1B IL1A
6
Show member pathways
13.33 TNF IL6 IL1B IL1A IGF1 CXCL8
7
Show member pathways
13.02 TNF TLR2 PRL INS IL6 IGF1
8
Show member pathways
12.9 TNF INS IL6 IL1B IL1A CXCL8
9
Show member pathways
12.86 TNF TLR2 IL6 IL1B IL1A CXCL8
10 12.79 TNF INS IL1B IL1A IGF1
11
Show member pathways
12.77 TNF TLR2 IL6 IL1B IL1A CXCL8
12
Show member pathways
12.75 TNF TLR2 IL6 IL1B IL1A IGF1
13
Show member pathways
12.63 TNF TLR2 IL6 IL1B IL1A
14
Show member pathways
12.63 TNF TLR2 PSTPIP1 IL6 IL1B IL1A
15
Show member pathways
12.39 TNF TLR2 IL6 IL1B CXCL8
16
Show member pathways
12.39 TNF SERPINA3 INS IL6 IL1B
17
Show member pathways
12.37 TNF IL6 IL1B IL1A CXCL8
18
Show member pathways
12.36 TNF IL6 CXCL8 CCR6
19 12.34 TNF TLR2 IL6 IL1B CXCL8
20 12.3 TNF IL6 IL1B CXCL8
21
Show member pathways
12.3 TNF TLR2 IL6 IL1A CXCL8
22
Show member pathways
12.29 TNF TLR2 IL1B IL1A
23
Show member pathways
12.29 TNF IL6 IL1B IL1A IGF1 CXCL8
24 12.27 TNF TLR2 IL6 IL1B IL1A
25 12.25 TNF PSTPIP1 MEFV IL6 IL1B CXCL8
26
Show member pathways
12.21 TNF TLR2 IL6 IL1B CXCL8
27 12.16 TNF IL6 IL1B IL1A CXCL8 AR
28 12.11 TNF PLIN2 INS IL6 IGF1
29 12.05 TNF MEFV IL6 IL1B CXCL8
30 12.04 TNF IL6 IL1B IL1A CXCL8
31
Show member pathways
12 TNF TLR2 IL6 IL1B
32 11.96 TNF IL6 IL1B IL1A
33 11.95 TNF TLR2 IL6 IL1B CXCL8
34 11.93 TNF IL6 IL1B IL1A CXCL8
35 11.86 PRL POMC IL6 CXCL8
36 11.81 TNF IL1B CCR6
37 11.79 TNF POMC IL6 IL1B IL1A CXCL8
38 11.77 TNF IL6 IL1B
39 11.77 TNF IL6 IL1B IL1A CXCL8
40 11.66 INS IL6 IL1B IL1A IGF1 CXCL8
41
Show member pathways
11.65 TNF IL6 IL1B IL1A CXCL8
42 11.63 TNF IL6 IL1B IGF1 CXCL8
43 11.62 INS IL6 CXCL8
44 11.56 TNF TLR2 IL1B
45 11.56 IL6 IL1B IL1A
46 11.56 INS IL6 IGF1
47 11.56 TNF TLR2 IL6 IL1B CXCL8
48 11.47 TNF TLR2 IL6 IL1B CXCL8
49 11.44 TNF IL6 IL1B
50 11.41 IL6 IL1B IL1A

GO Terms for Sebaceous Gland Disease

Cellular components related to Sebaceous Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 TNF SERPINA3 PRL POMC INS IL6
2 extracellular region GO:0005576 9.44 TNF SHBG SERPINA3 PRL POMC PLIN2

Biological processes related to Sebaceous Gland Disease according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.18 TNF TLR2 POMC IL6 IL1B IL1A
2 signal transduction GO:0007165 10.14 TLR2 PSTPIP1 PRL POMC INS IL6
3 positive regulation of cell proliferation GO:0008284 10.11 PRL INS IL6 IL1B IGF1 AR
4 negative regulation of cell proliferation GO:0008285 10.02 TLR2 IL6 IL1B IL1A CXCL8 AR
5 cellular protein metabolic process GO:0044267 9.98 PRL INS IL6 IGF1
6 cell-cell signaling GO:0007267 9.96 POMC INS IL1B AR AMH
7 positive regulation of MAPK cascade GO:0043410 9.91 INS IL6 IGF1 AR
8 cytokine-mediated signaling pathway GO:0019221 9.91 TNF POMC IL6 IL1B IL1A CXCL8
9 immune response GO:0006955 9.91 TNF TLR2 IL6 IL1B IL1A CXCL8
10 cellular response to lipopolysaccharide GO:0071222 9.89 TNF IL6 IL1B IL1A CXCL8
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 TNF IL6 IGF1
12 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 TNF TLR2 IL1B
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.85 TNF IL6 IGF1
14 humoral immune response GO:0006959 9.84 TNF IL6 CCR6
15 protein kinase B signaling GO:0043491 9.82 TNF IL1B IGF1
16 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.82 TNF IL1B IL1A
17 acute-phase response GO:0006953 9.81 SERPINA3 INS IL6
18 positive regulation of gene expression GO:0010628 9.81 TNF TLR2 INS IL6 IL1B IL1A
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 TNF TLR2 IL1B
20 positive regulation of cytokine secretion GO:0050715 9.78 TNF INS IL1A
21 positive regulation of JAK-STAT cascade GO:0046427 9.77 TNF PRL IL6
22 positive regulation of interleukin-8 production GO:0032757 9.77 TNF TLR2 IL1B
23 positive regulation of vascular endothelial growth factor production GO:0010575 9.76 IL6 IL1B IL1A
24 positive regulation of interleukin-6 production GO:0032755 9.76 TNF TLR2 IL6 IL1B
25 negative regulation of neurogenesis GO:0050768 9.74 TNF IL6 IL1B
26 positive regulation of chemokine production GO:0032722 9.71 TNF TLR2 IL6
27 positive regulation of glial cell proliferation GO:0060252 9.7 TNF IL6 IL1B
28 negative regulation of lipid catabolic process GO:0050995 9.69 TNF INS IL1B
29 negative regulation of lipid storage GO:0010888 9.68 TNF IL6
30 regulation of establishment of endothelial barrier GO:1903140 9.68 TNF IL1B
31 ectopic germ cell programmed cell death GO:0035234 9.67 IL1B IL1A
32 positive regulation of fever generation GO:0031622 9.66 TNF IL1B
33 positive regulation of immature T cell proliferation in thymus GO:0033092 9.65 IL1B IL1A
34 sequestering of triglyceride GO:0030730 9.65 TNF IL1B
35 positive regulation of neuroinflammatory response GO:0150078 9.65 TNF IL6 IL1B
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 TNF IL1B
37 fever generation GO:0001660 9.62 IL1B IL1A
38 positive regulation of interleukin-6 secretion GO:2000778 9.62 TNF TLR2 IL1B IL1A
39 positive regulation of mitotic nuclear division GO:0045840 9.56 INS IL1B IL1A IGF1
40 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.5 TNF TLR2 INS IL6 IL1B AR
41 inflammatory response GO:0006954 9.28 TNF TLR2 SERPINA3 PSTPIP1 MEFV IL6

Molecular functions related to Sebaceous Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 TNF IL6 IL1B IL1A CXCL8
2 steroid binding GO:0005496 9.33 SHBG CYP21A2 AR
3 androgen binding GO:0005497 9.26 SHBG AR
4 hormone activity GO:0005179 9.02 PRL POMC INS IGF1 AMH

Sources for Sebaceous Gland Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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