Sebaceous Gland Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SBC017 MIFTS: 40	Sebaceous Gland Disease Categories: Endocrine diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Sebaceous Gland Disease

MalaCards integrated aliases for Sebaceous Gland Disease:

Name: Sebaceous Gland Disease ¹² ¹⁵ ¹⁷

Sebaceous Gland Diseases ⁷¹

Sebaceous Gland Anomaly ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the skin and subcutaneous tissue

Disorders of skin appendages

Acne

Other acne

Orphanet: ⁵⁸

Rare skin diseases

External Ids:

Disease Ontology ¹² DOID:9098

ICD9CM ³⁴ 706.1

ICD10 ³² L70.8

Orphanet ⁵⁸ ORPHA79372

EFO ¹⁷ EFO_1000763

UMLS ⁷¹ C0029485 C0036502

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Summaries for Sebaceous Gland Disease

Disease Ontology : ¹² A skin disease that is located in the sebaceous gland.

MalaCards based summary : Sebaceous Gland Disease, also known as sebaceous gland diseases, is related to neurofibromatosis, type ii and alopecia, androgenetic, 1, and has symptoms including pruritus and exanthema. An important gene associated with Sebaceous Gland Disease is SHBG (Sex Hormone Binding Globulin), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include sebaceous gland and skin, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : ⁷⁴ A sebaceous gland is a microscopic exocrine gland in the skin that opens into a hair follicle to secrete... more...

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Related Diseases for Sebaceous Gland Disease

Diseases related to Sebaceous Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 676)

#	Related Disease	Score	Top Affiliating Genes
1	neurofibromatosis, type ii	33.2	TLR2 SHBG IL6 IL1A
2	alopecia, androgenetic, 1	30.8	SHBG CYP21A2 AR
3	seborrheic dermatitis	30.7	TNF SHBG IL1A CCR6
4	alopecia	30.6	TNF SHBG PRL IL1B IGF1 AR
5	androgenic alopecia	30.6	SHBG PRL INS IGF1 AR
6	rosacea	30.5	TNF TLR2 IL6 CXCL8 CCR6
7	skin disease	30.0	TNF TLR2 SIGLEC5 SERPINA3 IL6 IL1B
8	genetic sebaceous gland anomaly	12.5
9	steatocystoma multiplex	11.3
10	physiological polycythemia	10.7	TNF IL1B
11	mycobacterium chelonae	10.7	TLR2 CXCL8
12	external pathological resorption	10.7	TNF IL6
13	psoriatic juvenile idiopathic arthritis	10.7	PSTPIP1 MEFV
14	systemic onset juvenile idiopathic arthritis	10.7	TNF IL1B
15	mycobacterium marinum	10.7	TLR2 CXCL8
16	secondary adrenal insufficiency	10.7	INS IGF1
17	inhibited female orgasm	10.7	SHBG PRL
18	scorpion envenomation	10.7	TNF IL6
19	prostate adenoid cystic carcinoma	10.7	POMC AR
20	aspiration pneumonitis	10.7	TNF SERPINA3 CXCL8
21	adenohypophysitis	10.7	PRL POMC
22	wells syndrome	10.7	MEFV IL1B CXCL8
23	graves disease 1	10.7	SHBG POMC INS
24	staphylococcal toxic shock syndrome	10.7	TNF IL1B
25	haemophilus influenzae	10.7	TNF TLR2 CXCL8
26	galactorrhea	10.7	PRL IGF1
27	marasmus	10.7	SHBG INS IGF1
28	conjunctivitis	10.7	TNF IL6 CXCL8
29	mycobacterium abscessus	10.7	TNF TLR2 CXCL8
30	hypothalamic disease	10.7	PRL POMC INS
31	bacterial conjunctivitis	10.7	SIGLEC5 IL1B CXCL8
32	congenital cytomegalovirus	10.7	TNF TLR2 IL1B
33	mycobacterium kansasii	10.7	TLR2 CXCL8
34	aromatase excess syndrome	10.6	SHBG POMC IGF1
35	trichuriasis	10.6	TNF SERPINA3 CXCL8
36	hypothalamic obesity	10.6	INS IGF1
37	bagassosis	10.6	IL1B CXCL8
38	tuberculous meningitis	10.6	TNF TLR2 CXCL8
39	prostatic hyperplasia, benign	10.6	SHBG SERPINA3 AR
40	hormone producing pituitary cancer	10.6	PRL POMC IGF1
41	idiopathic anterior uveitis	10.6	TNF IL6 CXCL8
42	melancholia	10.6	TNF PRL POMC
43	atypical depressive disorder	10.6	SERPINA3 POMC IL6
44	streptococcal toxic-shock syndrome	10.6	TNF IL6 CXCL8
45	leukoregulin	10.6	IL1A CXCL8
46	diabetic encephalopathy	10.6	INS IL1B IGF1
47	cardiac sarcoidosis	10.6	TNF IL1B CXCL8
48	acute adrenal insufficiency	10.6	POMC IL6 CYP21A2
49	diabetes insipidus	10.6	PRL POMC INS
50	prosthetic joint infection	10.6	TLR2 IL6 IL1B

Graphical network of the top 20 diseases related to Sebaceous Gland Disease:

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Symptoms & Phenotypes for Sebaceous Gland Disease

UMLS symptoms related to Sebaceous Gland Disease:

pruritus, exanthema

MGI Mouse Phenotypes related to Sebaceous Gland Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.21	AR CCR6 CYP21A2 IGF1 IL1A IL1B
2	homeostasis/metabolism	MP:0005376	10.2	AMH AR CCR6 IGF1 IL1A IL1B
3	cardiovascular system	MP:0005385	10.13	AR CCR6 IGF1 IL1A IL1B IL6
4	immune system	MP:0005387	10.13	AR CCR6 CYP21A2 IGF1 IL1A IL1B
5	endocrine/exocrine gland	MP:0005379	10.1	AMH AR IGF1 IL6 INS PLIN2
6	adipose tissue	MP:0005375	10.06	AR IGF1 IL6 INS PLIN2 POMC
7	integument	MP:0010771	10	AR CYP21A2 IGF1 IL1A IL1B IL6
8	liver/biliary system	MP:0005370	9.61	AR IL6 INS MEFV PLIN2 POMC
9	neoplasm	MP:0002006	9.32	AMH AR IGF1 IL1A IL1B IL6

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Drugs & Therapeutics for Sebaceous Gland Disease

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Optical Clearing of the Skin in Conjunction With Laser Treatments	Completed	NCT00580736	Phase 1
2	A Multicenter Randomized, Double-Masked Study Comparing the Efficacy of Novabay iLid Cleanser Versus Vehicle on Ocular Skin Flora	Unknown status	NCT02455895

Search NIH Clinical Center for Sebaceous Gland Disease

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Genetic Tests for Sebaceous Gland Disease

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Anatomical Context for Sebaceous Gland Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Sebaceous Gland Disease:

¹⁹

Sebaceous Gland

MalaCards organs/tissues related to Sebaceous Gland Disease:

⁴⁰

Skin

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Publications for Sebaceous Gland Disease

Articles related to Sebaceous Gland Disease:

#	Title	Authors	PMID	Year
1	Combination of metformin and berberine represses the apoptosis of sebocytes in high-fat diet-induced diabetic hamsters and an insulin-treated human cell line. ⁶¹	Yao Y...Wei Y	32080865	2020
2	Primary sebocytes and sebaceous gland cell lines for studying sebaceous lipogenesis and sebaceous gland diseases. ⁶¹	Schneider MR...Zouboulis CC	29451719	2018
3	High prevalence of skin diseases and need for treatment in a middle-aged population. A Northern Finland Birth Cohort 1966 study. ⁶¹	Sinikumpu SP...Tasanen K	24911008	2014
4	New pharmaceutical concepts for sebaceous gland diseases: implementing today's pre-clinical data into tomorrow's daily clinical practice. ⁶¹	Zampeli VA...Zouboulis CC	22250709	2012
5	[Ectoparasites. Part 2: Bed bugs, Demodex, sand fleas and cutaneous larva migrans]. ⁶¹	Nenoff P...Paasch U	19701614	2009
6	Risk factors for sebaceous gland diseases and their relationship to gastrointestinal dysfunction in Han adolescents. ⁶¹	Zhang H...Ho HI	18837699	2008
7	A study of skin diseases in Tunis. An analysis of 28,244 dermatological outpatient cases. ⁶¹	Souissi A...Kamoun MR	17994171	2007

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Genes for Sebaceous Gland Disease

Genes related to Sebaceous Gland Disease (0 elite genes):

(show all 39)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SHBG	Sex Hormone Binding Globulin	Protein Coding	8.46	DISEASES inferred ¹⁵
2	SERPINA3	Serpin Family A Member 3	Protein Coding	8.28	DISEASES inferred ¹⁵ ¹⁵
3	PSTPIP1	Proline-Serine-Threonine Phosphatase Interacting Protein 1	Protein Coding	8.27	DISEASES inferred ¹⁵
4	SIGLEC5	Sialic Acid Binding Ig Like Lectin 5	Protein Coding	7.97	DISEASES inferred ¹⁵ ¹⁵
5	POMC	Proopiomelanocortin	Protein Coding	7.59	DISEASES inferred ¹⁵
6	INS	Insulin	Protein Coding	7.43	DISEASES inferred ¹⁵
7	TNF	Tumor Necrosis Factor	Protein Coding	7.17	DISEASES inferred ¹⁵
8	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	7.16	DISEASES inferred ¹⁵
9	TLR2	Toll Like Receptor 2	Protein Coding	7.16	DISEASES inferred ¹⁵
10	IL1B	Interleukin 1 Beta	Protein Coding	7.14	DISEASES inferred ¹⁵
11	PRL	Prolactin	Protein Coding	7.08	DISEASES inferred ¹⁵
12	IGF1	Insulin Like Growth Factor 1	Protein Coding	6.98	DISEASES inferred ¹⁵
13	IL1A	Interleukin 1 Alpha	Protein Coding	6.97	DISEASES inferred ¹⁵
14	CYP21A2	Cytochrome P450 Family 21 Subfamily A Member 2	Protein Coding	6.95	DISEASES inferred ¹⁵
15	MEFV	MEFV Innate Immuity Regulator, Pyrin	Protein Coding	6.89	DISEASES inferred ¹⁵
16	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	6.88	DISEASES inferred ¹⁵ ¹⁵
17	AR	Androgen Receptor	Protein Coding	6.86	DISEASES inferred ¹⁵
18	IL6	Interleukin 6	Protein Coding	6.79	DISEASES inferred ¹⁵
19	AMH	Anti-Mullerian Hormone	Protein Coding	6.77	DISEASES inferred ¹⁵
20	PLIN2	Perilipin 2	Protein Coding	6.71	DISEASES inferred ¹⁵
21	NCSTN	Nicastrin	Protein Coding	6.69	DISEASES inferred ¹⁵
22	MIR132	MicroRNA 132	RNA Gene	6.69	DISEASES inferred ¹⁵ ¹⁵
23	EGFR	Epidermal Growth Factor Receptor	Protein Coding	6.68	DISEASES inferred ¹⁵
24	DEFB4A	Defensin Beta 4A	Protein Coding	6.67	DISEASES inferred ¹⁵
25	ADSL	Adenylosuccinate Lyase	Protein Coding	6.67	DISEASES inferred ¹⁵
26	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	6.62	DISEASES inferred ¹⁵
27	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	6.6	DISEASES inferred ¹⁵
28	KRT17	Keratin 17	Protein Coding	6.54	DISEASES inferred ¹⁵
29	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	6.49	DISEASES inferred ¹⁵
30	TLR4	Toll Like Receptor 4	Protein Coding	6.44	DISEASES inferred ¹⁵
31	CAMP	Cathelicidin Antimicrobial Peptide	Protein Coding	6.43	DISEASES inferred ¹⁵
32	CRP	C-Reactive Protein	Protein Coding	6.42	DISEASES inferred ¹⁵
33	RARS1	Arginyl-TRNA Synthetase 1	Protein Coding	6.42	DISEASES inferred ¹⁵
34	CYP17A1	Cytochrome P450 Family 17 Subfamily A Member 1	Protein Coding	6.38	DISEASES inferred ¹⁵
35	MSH2	MutS Homolog 2	Protein Coding	6.37	DISEASES inferred ¹⁵
36	FLG	Filaggrin	Protein Coding	6.32	DISEASES inferred ¹⁵
37	LPIN2	Lipin 2	Protein Coding	6.31	DISEASES inferred ¹⁵
38	INSM1	INSM Transcriptional Repressor 1	Protein Coding	6.29	DISEASES inferred ¹⁵
39	IL17A	Interleukin 17A	Protein Coding	6.29	DISEASES inferred ¹⁵

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Variations for Sebaceous Gland Disease

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Expression for Sebaceous Gland Disease

Search GEO for disease gene expression data for Sebaceous Gland Disease.

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Pathways for Sebaceous Gland Disease

Pathways related to Sebaceous Gland Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 62)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	14.02	TNF TLR2 SIGLEC5 SERPINA3 PSTPIP1 PRL
2	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.71	TNF PRL INS IL6 IL1B IL1A
3	TGF-Beta Pathway ⁶³ Show member pathways JAK-STAT Pathway ⁶³ JNK Pathway ⁶³ MAPK Family Pathway ⁶³ Regulation of eIF4 and p70S6K ⁶³ SOCS Pathway ⁶³	13.57	TNF PRL INS IL6 IL1B IL1A
4	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.43	TNF TLR2 IL6 IL1B IL1A IGF1
5	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.38	TNF PRL POMC IL6 IL1B IL1A
6	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.33	TNF IL6 IL1B IL1A IGF1 CXCL8
7	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	13.02	TNF TLR2 PRL INS IL6 IGF1
8	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.9	TNF INS IL6 IL1B IL1A CXCL8
9	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.86	TNF TLR2 IL6 IL1B IL1A CXCL8
10	MAPK signaling pathway ³⁶ ¹	12.79	TNF INS IL1B IL1A IGF1
11	Toll-Like receptor Signaling Pathways ⁶⁴ Show member pathways IL-1 Family Signaling Pathways ⁶⁴ Immune response IL-1 signaling pathway ²² Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²² Inflammasome Activation Pathways ⁶⁴ Mucin expression in CF via TLRs, EGFR signaling pathways ²² NOD-like Receptor Signaling Pathways ⁶⁴	12.77	TNF TLR2 IL6 IL1B IL1A CXCL8
12	NF-KappaB Family Pathway ⁶³ Show member pathways NF-KappaB (p50-p65) Pathway ⁶³	12.75	TNF TLR2 IL6 IL1B IL1A IGF1
13	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁶ Th1 and Th2 cell differentiation ³⁶	12.63	TNF TLR2 IL6 IL1B IL1A
14	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.63	TNF TLR2 PSTPIP1 IL6 IL1B IL1A
15	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.39	TNF TLR2 IL6 IL1B CXCL8
16	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.39	TNF SERPINA3 INS IL6 IL1B
17	Toll Comparative Pathway ⁶³ Show member pathways IL-1 Pathway ⁶³ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶³ TLR-TRIF Pathway ⁶³	12.37	TNF IL6 IL1B IL1A CXCL8
18	Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	12.36	TNF IL6 CXCL8 CCR6
19	Salmonella infection (KEGG) ³⁶	12.34	TNF TLR2 IL6 IL1B CXCL8
20	Pathogenic Escherichia coli infection ³⁶	12.3	TNF IL6 IL1B CXCL8
21	Diseases associated with the TLR signaling cascade ⁶⁵ Show member pathways Diseases of Immune System ⁶⁵ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁵ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁵ IRAK4 deficiency (TLR2/4) ⁶⁵ IRAK4 deficiency (TLR5) ⁶⁵ MyD88 deficiency (TLR2/4) ⁶⁵ MyD88 deficiency (TLR5) ⁶⁵ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.3	TNF TLR2 IL6 IL1A CXCL8
22	Toxoplasmosis ³⁶ Show member pathways Leishmaniasis ³⁶	12.29	TNF TLR2 IL1B IL1A
23	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.29	TNF IL6 IL1B IL1A IGF1 CXCL8
24	Tuberculosis ³⁶	12.27	TNF TLR2 IL6 IL1B IL1A
25	NOD-like receptor signaling pathway ³⁶	12.25	TNF PSTPIP1 MEFV IL6 IL1B CXCL8
26	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	12.21	TNF TLR2 IL6 IL1B CXCL8
27	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.16	TNF IL6 IL1B IL1A CXCL8 AR
28	Adipogenesis ¹	12.11	TNF PLIN2 INS IL6 IGF1
29	Yersinia infection ³⁶	12.05	TNF MEFV IL6 IL1B CXCL8
30	Spinal Cord Injury ¹	12.04	TNF IL6 IL1B IL1A CXCL8
31	IL27-mediated signaling events ¹ Show member pathways IL12 Signaling Pathway ⁶⁶ Th1 Differentiation ⁶⁴	12	TNF TLR2 IL6 IL1B
32	Hematopoietic cell lineage ³⁶	11.96	TNF IL6 IL1B IL1A
33	Amoebiasis ³⁶	11.95	TNF TLR2 IL6 IL1B CXCL8
34	AGE-RAGE signaling pathway in diabetic complications ³⁶	11.93	TNF IL6 IL1B IL1A CXCL8
35	Glucocorticoid receptor regulatory network ¹	11.86	PRL POMC IL6 CXCL8
36	Innate Lymphoid Cells Differentiation ⁶⁴	11.81	TNF IL1B CCR6
37	Interleukin-4 and 13 signaling ⁶⁵	11.79	TNF POMC IL6 IL1B IL1A CXCL8
38	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.77	TNF IL6 IL1B
39	Pertussis ³⁶	11.77	TNF IL6 IL1B IL1A CXCL8
40	Senescence and Autophagy in Cancer ¹	11.66	INS IL6 IL1B IL1A IGF1 CXCL8
41	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.65	TNF IL6 IL1B IL1A CXCL8
42	Lung fibrosis ¹	11.63	TNF IL6 IL1B IGF1 CXCL8
43	ATF-2 transcription factor network ¹	11.62	INS IL6 CXCL8
44	MSP-RON Signaling ⁶³	11.56	TNF TLR2 IL1B
45	Hematopoietic Stem Cell Differentiation ¹	11.56	IL6 IL1B IL1A
46	Differentiation Pathway ¹	11.56	INS IL6 IGF1
47	Legionellosis ³⁶	11.56	TNF TLR2 IL6 IL1B CXCL8
48	Malaria ³⁶	11.47	TNF TLR2 IL6 IL1B CXCL8
49	African trypanosomiasis ³⁶	11.44	TNF IL6 IL1B
50	Prion diseases ³⁶	11.41	IL6 IL1B IL1A

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GO Terms for Sebaceous Gland Disease

Cellular components related to Sebaceous Gland Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.7	TNF SERPINA3 PRL POMC INS IL6
2	extracellular region	GO:0005576	9.44	TNF SHBG SERPINA3 PRL POMC PLIN2

Biological processes related to Sebaceous Gland Disease according to GeneCards Suite gene sharing:

(show all 41)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	10.18	TNF TLR2 POMC IL6 IL1B IL1A
2	signal transduction	GO:0007165	10.14	TLR2 PSTPIP1 PRL POMC INS IL6
3	positive regulation of cell proliferation	GO:0008284	10.11	PRL INS IL6 IL1B IGF1 AR
4	negative regulation of cell proliferation	GO:0008285	10.02	TLR2 IL6 IL1B IL1A CXCL8 AR
5	cellular protein metabolic process	GO:0044267	9.98	PRL INS IL6 IGF1
6	cell-cell signaling	GO:0007267	9.96	POMC INS IL1B AR AMH
7	positive regulation of MAPK cascade	GO:0043410	9.91	INS IL6 IGF1 AR
8	cytokine-mediated signaling pathway	GO:0019221	9.91	TNF POMC IL6 IL1B IL1A CXCL8
9	immune response	GO:0006955	9.91	TNF TLR2 IL6 IL1B IL1A CXCL8
10	cellular response to lipopolysaccharide	GO:0071222	9.89	TNF IL6 IL1B IL1A CXCL8
11	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.85	TNF IL6 IGF1
12	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.85	TNF TLR2 IL1B
13	positive regulation of smooth muscle cell proliferation	GO:0048661	9.85	TNF IL6 IGF1
14	humoral immune response	GO:0006959	9.84	TNF IL6 CCR6
15	protein kinase B signaling	GO:0043491	9.82	TNF IL1B IGF1
16	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	9.82	TNF IL1B IL1A
17	acute-phase response	GO:0006953	9.81	SERPINA3 INS IL6
18	positive regulation of gene expression	GO:0010628	9.81	TNF TLR2 INS IL6 IL1B IL1A
19	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.8	TNF TLR2 IL1B
20	positive regulation of cytokine secretion	GO:0050715	9.78	TNF INS IL1A
21	positive regulation of JAK-STAT cascade	GO:0046427	9.77	TNF PRL IL6
22	positive regulation of interleukin-8 production	GO:0032757	9.77	TNF TLR2 IL1B
23	positive regulation of vascular endothelial growth factor production	GO:0010575	9.76	IL6 IL1B IL1A
24	positive regulation of interleukin-6 production	GO:0032755	9.76	TNF TLR2 IL6 IL1B
25	negative regulation of neurogenesis	GO:0050768	9.74	TNF IL6 IL1B
26	positive regulation of chemokine production	GO:0032722	9.71	TNF TLR2 IL6
27	positive regulation of glial cell proliferation	GO:0060252	9.7	TNF IL6 IL1B
28	negative regulation of lipid catabolic process	GO:0050995	9.69	TNF INS IL1B
29	negative regulation of lipid storage	GO:0010888	9.68	TNF IL6
30	regulation of establishment of endothelial barrier	GO:1903140	9.68	TNF IL1B
31	ectopic germ cell programmed cell death	GO:0035234	9.67	IL1B IL1A
32	positive regulation of fever generation	GO:0031622	9.66	TNF IL1B
33	positive regulation of immature T cell proliferation in thymus	GO:0033092	9.65	IL1B IL1A
34	sequestering of triglyceride	GO:0030730	9.65	TNF IL1B
35	positive regulation of neuroinflammatory response	GO:0150078	9.65	TNF IL6 IL1B
36	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.62	TNF IL1B
37	fever generation	GO:0001660	9.62	IL1B IL1A
38	positive regulation of interleukin-6 secretion	GO:2000778	9.62	TNF TLR2 IL1B IL1A
39	positive regulation of mitotic nuclear division	GO:0045840	9.56	INS IL1B IL1A IGF1
40	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.5	TNF TLR2 INS IL6 IL1B AR
41	inflammatory response	GO:0006954	9.28	TNF TLR2 SERPINA3 PSTPIP1 MEFV IL6

Molecular functions related to Sebaceous Gland Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.35	TNF IL6 IL1B IL1A CXCL8
2	steroid binding	GO:0005496	9.33	SHBG CYP21A2 AR
3	androgen binding	GO:0005497	9.26	SHBG AR
4	hormone activity	GO:0005179	9.02	PRL POMC INS IGF1 AMH

Sources

Sources for Sebaceous Gland Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia