MCID: SBC018
MIFTS: 32

Sebaceous Gland Neoplasm

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Sebaceous Gland Neoplasm

MalaCards integrated aliases for Sebaceous Gland Neoplasm:

Name: Sebaceous Gland Neoplasm 12 15 17
Sebaceous Gland Neoplasms 54 44
Sebaceous Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5759
MeSH 44 D012626
NCIt 50 C3363
SNOMED-CT 67 126491004
UMLS 70 C0036503

Summaries for Sebaceous Gland Neoplasm

MalaCards based summary : Sebaceous Gland Neoplasm, also known as sebaceous gland neoplasms, is related to adenoma and lynch syndrome i. An important gene associated with Sebaceous Gland Neoplasm is MLH1 (MutL Homolog 1), and among its related pathways/superpathways are DNA Double-Strand Break Repair and DNA Damage. Affiliated tissues include colon, breast and small intestine, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Sebaceous Gland Neoplasm

Diseases related to Sebaceous Gland Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 adenoma 30.1 MUTYH MSH6 MSH2 MLH1
2 lynch syndrome i 29.1 PMS2 PMS1 MSH6 MSH2 MLH1 EPCAM
3 lynch syndrome 29.0 PMS2 PMS1 MUTYH MSH6 MSH2 MLH1
4 muir-torre syndrome 29.0 PMS2 PMS1 PLIN2 MUTYH MSH6 MSH2
5 hereditary nonpolyposis colon cancer 28.8 PMS2 PMS1 MUTYH MSH6 MSH2 MLH1
6 sebaceous adenocarcinoma 28.7 PMS2 PMS1 PLIN2 MSH6 MSH2 MLH1
7 sebaceous adenoma 28.1 SERPINA3 PMS2 PLIN2 PLET1 MUTYH MSH6
8 colorectal cancer 2 10.3 MSH2 MLH1
9 spindle cell intraocular melanoma 10.3 PMS2 MLH1
10 silent pituitary adenoma 10.3 MSH6 MSH2
11 intracranial meningioma 10.3 MSH2 MLH1
12 transverse colon cancer 10.3 PMS2 MLH1
13 ascending colon cancer 10.3 MSH2 MLH1
14 lower lip cancer 10.3 MSH2 MLH1
15 periampullary adenoma 10.3 PMS2 MSH6
16 endometrioid ovary carcinoma 10.3 MSH6 MLH1
17 esophageal tuberculosis 10.3 PMS2 MSH6
18 anal fistula 10.3 MSH2 MLH1
19 fallopian tube endometrioid adenocarcinoma 10.3 PMS2 MSH6
20 myh-associated polyposis 10.3 MUTYH MSH2
21 melanocytic nevus syndrome, congenital 10.3 MSH2 MLH1
22 gastrointestinal adenoma 10.2 PMS2 MUTYH
23 familial adenomatous polyposis 2 10.2 MUTYH MLH1
24 renal pelvis transitional cell carcinoma 10.2 MSH6 MSH2 MLH1
25 legius syndrome 10.2 MSH6 MSH2
26 autosomal dominant non-syndromic intellectual disability 8 10.2 MSH6 MSH2 MLH1
27 breast-ovarian cancer, familial 1 10.2 MSH6 MSH2 MLH1
28 ureter, cancer of 10.2 MSH2 MLH1
29 cecum carcinoma 10.2 MSH6 MSH2 MLH1
30 esophagus sarcoma 10.2 PMS2 MSH6 MSH2
31 cervical adenosarcoma 10.2 PMS2 MSH6 MSH2
32 t-cell non-hodgkin lymphoma 10.2 PMS2 MSH6 MSH2
33 pituitary carcinoma 10.2 PMS2 MSH6
34 endometrial hyperplasia 10.2 MSH6 MSH2 MLH1
35 uterine body mixed cancer 10.2 MSH6 MLH1
36 melanoma, cutaneous malignant 1 10.2 MSH6 MSH2 MLH1
37 squamous papillomatosis 10.2 KRT15 EPCAM
38 familial colorectal cancer 10.2 MUTYH MSH2 MLH1
39 attenuated familial adenomatous polyposis 10.2 MUTYH MSH6 MSH2
40 colorectal adenoma 10.1 MUTYH MSH2 MLH1
41 rectosigmoid cancer 10.1 PMS2 MUTYH MSH6
42 sebaceous gland disease 10.1 SERPINA3 PLIN2 MSH2
43 neuroma 10.1 SERPINA3 MUTYH MSH2
44 anaplastic astrocytoma 10.1 SERPINA3 PMS2 MLH1
45 extrahepatic bile duct adenoma 10.1 PMS2 MSH6 MSH2 MLH1
46 cell type benign neoplasm 10.1 SERPINA3 MUTYH MLH1
47 mismatch repair cancer syndrome 10.1 PMS2 MSH6 MSH2 MLH1
48 adenosquamous colon carcinoma 10.1 PMS2 MSH6 MSH2 MLH1
49 appendix carcinoid tumor 10.1 PMS2 MSH6 MSH2 MLH1
50 small intestine adenocarcinoma 10.1 PMS2 MSH6 MSH2 MLH1

Graphical network of the top 20 diseases related to Sebaceous Gland Neoplasm:



Diseases related to Sebaceous Gland Neoplasm

Symptoms & Phenotypes for Sebaceous Gland Neoplasm

GenomeRNAi Phenotypes related to Sebaceous Gland Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.23 MLH1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.23 MLH1
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.23 MLH1 MSH2 MSH6 MUTYH PMS1 PMS2

MGI Mouse Phenotypes related to Sebaceous Gland Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.93 EPCAM KRT14 KRT15 LRIG1 MLH1 MSH2
2 digestive/alimentary MP:0005381 9.86 EPCAM KRT14 KRT15 LRIG1 MLH1 MSH2
3 integument MP:0010771 9.5 KRT14 LRIG1 MLH1 MSH2 MSH6 PLIN2
4 neoplasm MP:0002006 9.28 KRT14 LRIG1 MLH1 MSH2 MSH6 MUTYH

Drugs & Therapeutics for Sebaceous Gland Neoplasm

Search Clinical Trials , NIH Clinical Center for Sebaceous Gland Neoplasm

Cochrane evidence based reviews: sebaceous gland neoplasms

Genetic Tests for Sebaceous Gland Neoplasm

Anatomical Context for Sebaceous Gland Neoplasm

MalaCards organs/tissues related to Sebaceous Gland Neoplasm:

40
Colon, Breast, Small Intestine, Skin, Ovary, Appendix, Pituitary

Publications for Sebaceous Gland Neoplasm

Articles related to Sebaceous Gland Neoplasm:

(show all 23)
# Title Authors PMID Year
1
Muir-Torre syndrome. 61 54
16962019 2006
2
Neoplastic diseases in the domestic ferret (Mustela putorius furo) in Italy: classification and tissue distribution of 856 cases (2000-2010). 61
27919252 2016
3
Muir-Torre Syndrome: A Case Associated with an Infrequent Gene Mutation. 61
26962393 2016
4
Histopathological findings and proliferative activity of canine sebaceous gland tumours with a predominant reserve cell population. 61
25678426 2015
5
[Sebaceous gland tumor with a rare gene mutation within a tumor syndrome: Muir-Torre syndrome]. 61
23774967 2014
6
Synchronous gastric and sebaceous cancers, a rare manifestation of MLH1-related Muir-Torre syndrome. 61
25197397 2014
7
Muir-Torre syndrome: a case report and review of the literature. 61
22965514 2012
8
The liver: another organ involved in Muir Torre syndrome? 61
21614588 2012
9
Metastatic breast carcinoma mimicking a sebaceous gland neoplasm: a case report. 61
21888625 2011
10
Ileocecal adenocarcinoma and ureteral transitional cell carcinoma with multiple sebaceous tumors and keratoacanthomas in a case of muir-torre syndrome. 61
20814549 2010
11
Cutaneous sebaceous neoplasms as markers of Muir-Torre syndrome: a diagnostic algorithm. 61
19515040 2009
12
All patients with sebaceous gland neoplasms should be screened for Muir-Torre syndrome. 61
19187311 2009
13
Muir-Torre syndrome: a rare but important disorder. 61
19055168 2008
14
MSH-6: extending the reliability of immunohistochemistry as a screening tool in Muir-Torre syndrome. 61
18065960 2008
15
The importance of functional testing in the genetic assessment of Muir-Torre syndrome, a clinical subphenotype of HNPCC. 61
16327991 2006
16
Sex steroid hormone receptors in human skin appendage and its neoplasms. 61
16006726 2005
17
Muir-Torre syndrome: a case report and review of the literature. 61
15839358 2005
18
Sebaceous adenoma in the retromolar region: report of a case with a review of the English literature. 61
14505629 2003
19
Loss of mismatch repair proteins in sebaceous gland tumors. 61
12641777 2003
20
Spontaneous skin neoplasms in aged Sprague-Dawley rats. 61
1295064 1992
21
Sebaceous gland tumors and systemic disease: a clinicopathologic analysis. 61
6738344 1984
22
[Torre-Muir syndrome. Sebaceous gland neoplasms, keratoacanthomas, multiple internal cancers and heredity]. 61
7298331 1981
23
Bioassay of cupferron for possible carcinogenicity (CAS No. 135-20-6). 61
12806391 1978

Variations for Sebaceous Gland Neoplasm

Expression for Sebaceous Gland Neoplasm

Search GEO for disease gene expression data for Sebaceous Gland Neoplasm.

Pathways for Sebaceous Gland Neoplasm

GO Terms for Sebaceous Gland Neoplasm

Cellular components related to Sebaceous Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 9.16 PMS2 MLH1
2 mismatch repair complex GO:0032300 9.02 PMS2 PMS1 MSH6 MSH2 MLH1
3 MutSalpha complex GO:0032301 8.96 MSH6 MSH2

Biological processes related to Sebaceous Gland Neoplasm according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.85 PMS2 PMS1 MUTYH MSH6 MSH2 MLH1
2 DNA repair GO:0006281 9.73 PMS2 PMS1 MUTYH MSH6 MSH2 MLH1
3 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.61 MSH6 MSH2 MLH1
4 determination of adult lifespan GO:0008340 9.54 MSH6 MSH2
5 negative regulation of DNA recombination GO:0045910 9.52 MSH6 MSH2
6 positive regulation of isotype switching to IgG isotypes GO:0048304 9.51 MSH2 MLH1
7 isotype switching GO:0045190 9.5 MSH6 MSH2 MLH1
8 positive regulation of helicase activity GO:0051096 9.49 MSH6 MSH2
9 positive regulation of isotype switching to IgA isotypes GO:0048298 9.48 MSH2 MLH1
10 maintenance of DNA repeat elements GO:0043570 9.46 MSH6 MSH2
11 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.4 MSH2 MLH1
12 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MSH6 MSH2 MLH1
13 somatic hypermutation of immunoglobulin genes GO:0016446 9.26 PMS2 MSH6 MSH2 MLH1
14 mismatch repair GO:0006298 9.1 PMS2 PMS1 MUTYH MSH6 MSH2 MLH1

Molecular functions related to Sebaceous Gland Neoplasm according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.8 PMS1 MSH6 MSH2 MLH1
2 ATPase activity GO:0016887 9.77 PMS2 PMS1 MSH6 MSH2 MLH1
3 single-stranded DNA binding GO:0003697 9.63 PMS2 MSH2 MLH1
4 MutSalpha complex binding GO:0032407 9.5 PMS2 MUTYH MLH1
5 four-way junction DNA binding GO:0000400 9.48 MSH6 MSH2
6 single guanine insertion binding GO:0032142 9.43 MSH6 MSH2
7 MutLalpha complex binding GO:0032405 9.43 MUTYH MSH6 MSH2
8 single thymine insertion binding GO:0032143 9.4 MSH6 MSH2
9 oxidized purine DNA binding GO:0032357 9.33 MUTYH MSH6 MSH2
10 guanine/thymine mispair binding GO:0032137 9.13 MSH6 MSH2 MLH1
11 mismatched DNA binding GO:0030983 9.02 PMS2 PMS1 MSH6 MSH2 MLH1

Sources for Sebaceous Gland Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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