MCID: SBC018
MIFTS: 33

Sebaceous Gland Neoplasm

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Sebaceous Gland Neoplasm

MalaCards integrated aliases for Sebaceous Gland Neoplasm:

Name: Sebaceous Gland Neoplasm 12 15 17
Sebaceous Gland Neoplasms 56 45
Sebaceous Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5759
MeSH 45 D012626
NCIt 51 C3363
UMLS 74 C0036503

Summaries for Sebaceous Gland Neoplasm

MalaCards based summary : Sebaceous Gland Neoplasm, also known as sebaceous gland neoplasms, is related to sebaceous adenocarcinoma and lynch syndrome. An important gene associated with Sebaceous Gland Neoplasm is MSH2 (MutS Homolog 2), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Regulation of TP53 Activity. The drugs Lidocaine and Central Nervous System Depressants have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and immune system

Related Diseases for Sebaceous Gland Neoplasm

Diseases related to Sebaceous Gland Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 sebaceous adenocarcinoma 30.6 MLH1 MSH2 MSH6 PLIN2 PMS2
2 lynch syndrome 29.3 MLH1 MSH2 MSH6 PMS2
3 muir-torre syndrome 28.7 MLH1 MSH2 MSH6 PLIN2 PMS2
4 colorectal cancer, hereditary nonpolyposis, type 7 10.1 MLH1 MSH2
5 lower lip cancer 10.1 MLH1 MSH2
6 anal fistula 10.1 MLH1 MSH2
7 melanocytic nevus syndrome, congenital 10.1 MLH1 MSH2
8 attenuated familial adenomatous polyposis 10.1 MSH2 MSH6
9 childhood kidney cell carcinoma 10.1 MLH1 MSH2
10 colorectal cancer 5 10.1 MLH1 MSH6
11 sebaceous gland disease 10.0 MSH2 PLIN2
12 gastric leiomyoma 10.0 MLH1 MSH6
13 intestinal benign neoplasm 10.0 MLH1 MSH2
14 legius syndrome 10.0 MSH2 MSH6
15 keratoacanthoma 10.0 MLH1 MSH2
16 familial colorectal cancer 10.0 MLH1 MSH2
17 colorectal adenoma 9.9 MLH1 MSH2
18 gastrointestinal system disease 9.9 MLH1 MSH2
19 spindle cell intraocular melanoma 9.9 MLH1 PMS2
20 basal cell carcinoma 1 9.9
21 acanthoma 9.9
22 basal cell carcinoma 9.9
23 eccrine acrospiroma 9.9
24 cecum adenocarcinoma 9.9 MLH1 MSH2 MSH6
25 skin benign neoplasm 9.9 MLH1 MSH2 MSH6
26 colorectal cancer, hereditary nonpolyposis, type 5 9.9 MLH1 MSH2 MSH6
27 colorectal adenocarcinoma 9.9 MLH1 MSH2 MSH6
28 female reproductive system disease 9.9 MLH1 MSH2 MSH6
29 familial adenomatous polyposis 9.8 MLH1 MSH2 MSH6
30 hereditary breast ovarian cancer syndrome 9.7 MLH1 MSH6
31 colorectal cancer, hereditary nonpolyposis, type 4 9.7 MLH1 MSH2 PMS2
32 neurofibromatosis, type iv, of riccardi 9.6 MSH6 PMS2
33 rhabdomyosarcoma 9.6 MSH2 MSH6 PMS2
34 brain cancer 9.5 MSH2 MSH6 PMS2
35 appendix carcinoid tumor 9.4 MLH1 MSH2 MSH6 PMS2
36 adenosquamous colon carcinoma 9.4 MLH1 MSH2 MSH6 PMS2
37 sebaceous adenoma 9.4 MLH1 MSH2 MSH6 PMS2
38 lynch syndrome i 9.4 MLH1 MSH2 MSH6 PMS2
39 small intestine cancer 9.4 MLH1 MSH2 MSH6 PMS2
40 mismatch repair cancer syndrome 9.4 MLH1 MSH2 MSH6 PMS2
41 uterine anomalies 9.4 MLH1 MSH2 MSH6 PMS2
42 colonic disease 9.4 MLH1 MSH2 MSH6 PMS2
43 autosomal genetic disease 9.4 MLH1 MSH2 MSH6 PMS2
44 intestinal disease 9.4 MLH1 MSH2 MSH6 PMS2
45 gastrointestinal system cancer 9.4 MLH1 MSH2 MSH6 PMS2
46 autosomal dominant disease 9.4 MLH1 MSH2 MSH6 PMS2
47 large intestine cancer 9.4 MLH1 MSH2 MSH6 PMS2
48 endometrial cancer 9.4 MLH1 MSH2 MSH6 PMS2

Graphical network of the top 20 diseases related to Sebaceous Gland Neoplasm:



Diseases related to Sebaceous Gland Neoplasm

Symptoms & Phenotypes for Sebaceous Gland Neoplasm

GenomeRNAi Phenotypes related to Sebaceous Gland Neoplasm according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.92 MLH1 MSH2 MSH6 PMS2

MGI Mouse Phenotypes related to Sebaceous Gland Neoplasm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.35 MLH1 MSH2 MSH6 PLIN2 PMS2
2 neoplasm MP:0002006 8.92 MLH1 MSH2 MSH6 PMS2

Drugs & Therapeutics for Sebaceous Gland Neoplasm

Drugs for Sebaceous Gland Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2 Central Nervous System Depressants Phase 4
3 Peripheral Nervous System Agents Phase 4
4 Anti-Arrhythmia Agents Phase 4
5 Sodium Channel Blockers Phase 4
6 Anesthetics Phase 4
7 Anesthetics, Local Phase 4
8 Diuretics, Potassium Sparing Phase 4
9
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
10
nivolumab Approved Phase 2 946414-94-4
11 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pain Outcomes Following Intralesional Corticosteroid Injections Recruiting NCT03630198 Phase 4 Corticosteroid with lidocaine;Corticosteroid with normal saline
2 Study of TVEC in Patients With Cutaneous Squamous Cell Cancer Recruiting NCT03714828 Phase 2 Injection of TVEC into target lesions - week 1-2;Injection of TVEC into target lesions 3wks after 1st injection;Injection of TVEC into target lesions 2wks after 2nd injection;Injection of TVEC into target lesions 2wks after 3rd injection
3 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Sebaceous Gland Neoplasm

Cochrane evidence based reviews: sebaceous gland neoplasms

Genetic Tests for Sebaceous Gland Neoplasm

Anatomical Context for Sebaceous Gland Neoplasm

MalaCards organs/tissues related to Sebaceous Gland Neoplasm:

42
Skin

Publications for Sebaceous Gland Neoplasm

Articles related to Sebaceous Gland Neoplasm:

# Title Authors Year
1
Metastatic breast carcinoma mimicking a sebaceous gland neoplasm: a case report. ( 21888625 )
2011

Variations for Sebaceous Gland Neoplasm

Expression for Sebaceous Gland Neoplasm

Search GEO for disease gene expression data for Sebaceous Gland Neoplasm.

Pathways for Sebaceous Gland Neoplasm

Pathways related to Sebaceous Gland Neoplasm according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 MLH1 MSH2 MSH6 PMS2
2
Show member pathways
12.56 MLH1 MSH2 PMS2
3
Show member pathways
12.51 MLH1 MSH2 MSH6
4
Show member pathways
12.46 MLH1 MSH2 MSH6
5 12.42 MLH1 MSH2 MSH6
6 12.05 MLH1 MSH2 MSH6
7 11.72 MLH1 MSH2 MSH6
8 11.55 MLH1 MSH2 PMS2
9 11.52 MLH1 PMS2
10
Show member pathways
11.43 MSH2 MSH6
11
Show member pathways
11.25 MLH1 MSH2 MSH6 PMS2
12 11.2 MLH1 MSH2 MSH6
13 11.16 MSH2 MSH6
14 11.15 MLH1 MSH2 MSH6
15
Show member pathways
11.12 MLH1 MSH2
16
Show member pathways
11.06 MLH1 MSH2
17 10.39 MLH1 MSH2 MSH6 PMS2

GO Terms for Sebaceous Gland Neoplasm

Cellular components related to Sebaceous Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.73 MLH1 MSH2 MSH6 PLIN2 PMS2 SERPINA3
2 MutLalpha complex GO:0032389 9.16 MLH1 PMS2
3 MutSalpha complex GO:0032301 8.96 MSH2 MSH6
4 mismatch repair complex GO:0032300 8.92 MLH1 MSH2 MSH6 PMS2

Biological processes related to Sebaceous Gland Neoplasm according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.84 MLH1 MSH2 MSH6 PMS2
2 DNA repair GO:0006281 9.78 MLH1 MSH2 MSH6 PMS2
3 regulation of lipid metabolic process GO:0019216 9.58 PLIN2 SERPINA3
4 negative regulation of DNA recombination GO:0045910 9.57 MSH2 MSH6
5 determination of adult lifespan GO:0008340 9.56 MSH2 MSH6
6 positive regulation of isotype switching to IgG isotypes GO:0048304 9.55 MLH1 MSH2
7 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.54 MLH1 MSH2 MSH6
8 positive regulation of helicase activity GO:0051096 9.52 MSH2 MSH6
9 maintenance of DNA repeat elements GO:0043570 9.46 MSH2 MSH6
10 positive regulation of isotype switching to IgA isotypes GO:0048298 9.43 MLH1 MSH2
11 isotype switching GO:0045190 9.43 MLH1 MSH2 MSH6
12 somatic recombination of immunoglobulin gene segments GO:0016447 9.33 MLH1 MSH2 MSH6
13 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MLH1 MSH2
14 interstrand cross-link repair GO:0036297 9.27 MSH6
15 mismatch repair GO:0006298 9.26 MLH1 MSH2 MSH6 PMS2
16 pyrimidine dimer repair GO:0006290 9.21 MSH6
17 replication fork arrest GO:0043111 9.19 MSH6
18 meiotic mismatch repair GO:0000710 9.1 MSH6
19 somatic hypermutation of immunoglobulin genes GO:0016446 8.92 MLH1 MSH2 MSH6 PMS2

Molecular functions related to Sebaceous Gland Neoplasm according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.86 MLH1 MSH2 MSH6 PMS2
2 chromatin binding GO:0003682 9.71 MLH1 MSH2 MSH6
3 enzyme binding GO:0019899 9.7 MLH1 MSH2 MSH6
4 single-stranded DNA binding GO:0003697 9.63 MLH1 MSH2 PMS2
5 damaged DNA binding GO:0003684 9.55 MSH2 MSH6
6 DNA-dependent ATPase activity GO:0008094 9.51 MSH2 MSH6
7 ADP binding GO:0043531 9.49 MSH2 MSH6
8 four-way junction DNA binding GO:0000400 9.48 MSH2 MSH6
9 ATPase activity GO:0016887 9.46 MLH1 MSH2 MSH6 PMS2
10 MutLalpha complex binding GO:0032405 9.43 MSH2 MSH6
11 MutSalpha complex binding GO:0032407 9.4 MLH1 PMS2
12 oxidized purine DNA binding GO:0032357 9.37 MSH2 MSH6
13 single thymine insertion binding GO:0032143 9.32 MSH2 MSH6
14 single guanine insertion binding GO:0032142 9.26 MSH2 MSH6
15 guanine/thymine mispair binding GO:0032137 9.13 MLH1 MSH2 MSH6
16 mismatched DNA binding GO:0030983 8.92 MLH1 MSH2 MSH6 PMS2

Sources for Sebaceous Gland Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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