SLDP
MCID: SBR007
MIFTS: 21

Seborrhea-Like Dermatitis with Psoriasiform Elements (SLDP)

Categories: Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Seborrhea-Like Dermatitis with Psoriasiform Elements

MalaCards integrated aliases for Seborrhea-Like Dermatitis with Psoriasiform Elements:

Name: Seborrhea-Like Dermatitis with Psoriasiform Elements 57 58 72 29 13 6 39
Seborrhea-Like Dermatitis with Psoriasiform Element 36
Sldp 72

Characteristics:

Orphanet epidemiological data:

58
seborrhea-like dermatitis with psoriasiform elements
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Childhood;

HPO:

31
seborrhea-like dermatitis with psoriasiform elements:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

OMIM® 57 610227
KEGG 36 H00795
UMLS via Orphanet 71 C1853258
Orphanet 58 ORPHA168606
MedGen 41 C1853258

Summaries for Seborrhea-Like Dermatitis with Psoriasiform Elements

UniProtKB/Swiss-Prot : 72 Seborrhea-like dermatitis with psoriasiform elements: Characterized by a chronic fine diffuse scaly erythematous rash on the face, particularly on the chin, nasolabial folds and eyebrows, around earlobes and over the scalp. The rash exacerbate in the winter, with emotional stress and after strenuous physical activity. Hyperkeratosis of skin over the elbows, knees, palms, soles and metacarpophalangeal joints is evident. There is no arthralgia, arthritis or neurological disorders.

MalaCards based summary : Seborrhea-Like Dermatitis with Psoriasiform Elements, also known as seborrhea-like dermatitis with psoriasiform element, is related to psoriasis 2 and dermatitis. An important gene associated with Seborrhea-Like Dermatitis with Psoriasiform Elements is ZNF750 (Zinc Finger Protein 750). Affiliated tissues include pancreas, and related phenotypes are hyperkeratosis and seborrheic dermatitis

KEGG : 36 Seborrhea-like dermatosis with psoriasiform elements is a chronic dermatosis characterized by common dandruffs and eczematous or psoriasiform plaques. Enhanced keratinocyte proliferation and dermal infiltration of inflammatory cells are observed in the disease. Mutations in ZNF750, which encodes a putative C2H2 zinc finger protein, have been reported.

More information from OMIM: 610227

Related Diseases for Seborrhea-Like Dermatitis with Psoriasiform Elements

Diseases related to Seborrhea-Like Dermatitis with Psoriasiform Elements via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 psoriasis 2 10.3
2 dermatitis 10.3
3 overgrowth syndrome 10.3

Symptoms & Phenotypes for Seborrhea-Like Dermatitis with Psoriasiform Elements

Human phenotypes related to Seborrhea-Like Dermatitis with Psoriasiform Elements:

31
# Description HPO Frequency HPO Source Accession
1 hyperkeratosis 31 HP:0000962
2 seborrheic dermatitis 31 HP:0001051

Clinical features from OMIM®:

610227 (Updated 05-Apr-2021)

Drugs & Therapeutics for Seborrhea-Like Dermatitis with Psoriasiform Elements

Search Clinical Trials , NIH Clinical Center for Seborrhea-Like Dermatitis with Psoriasiform Elements

Genetic Tests for Seborrhea-Like Dermatitis with Psoriasiform Elements

Genetic tests related to Seborrhea-Like Dermatitis with Psoriasiform Elements:

# Genetic test Affiliating Genes
1 Seborrhea-Like Dermatitis with Psoriasiform Elements 29 ZNF750

Anatomical Context for Seborrhea-Like Dermatitis with Psoriasiform Elements

MalaCards organs/tissues related to Seborrhea-Like Dermatitis with Psoriasiform Elements:

40
Pancreas

Publications for Seborrhea-Like Dermatitis with Psoriasiform Elements

Articles related to Seborrhea-Like Dermatitis with Psoriasiform Elements:

(show all 14)
# Title Authors PMID Year
1
Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein. 61 57 6
16751772 2006
2
Extended laparoscopic distal pancreatectomy for adenocarcinoma in the body and tail of the pancreas: a single-center experience. 61
30417281 2018
3
A study on the correlation between the dewetting temperature of Ag film and SERS intensity. 61
29116240 2017
4
Laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: results of a multicenter cohort study on 196 patients. 61
26514135 2016
5
Effectiveness and safety of double-balloon catheter versus intra-amniotic injection of ethacridine lactate for termination of second trimester pregnancy in patients with liver dysfunction. 61
25673206 2015
6
SLDP: a novel protein related to caleosin is associated with the endosymbiotic Symbiodinium lipid droplets from Euphyllia glabrescens. 61
24820937 2014
7
A wireless object location detector enabling people with developmental disabilities to control environmental stimulation through simple occupational activities with Nintendo Wii Balance Boards. 61
22502821 2012
8
Low achieved diastolic pressure in tightly controlled mid-older hypertensive subjects is associated with favorable arterial properties. 61
22149975 2012
9
A standing location detector enabling people with developmental disabilities to control environmental stimulation through simple physical activities with Nintendo Wii Balance Boards. 61
21159488 2011
10
Survivability and causes of loss of broody-hen chicks on smallholder households in Bangladesh. 61
17850905 2008
11
Causes of loss of Sonali chickens on smallholder households in Bangladesh. 61
16774795 2006
12
Light and electron microscopic study of corticorubral synapses in adult cat: evidence for extensive synaptic remodeling during postnatal development. 61
11745620 2001
13
Preferential termination of corticorubral axons on spine-like dendritic protrusions in developing cat. 61
9348348 1997
14
Developing corticorubral axons of the cat form synapses on filopodial dendritic protrusions. 61
1480328 1992

Variations for Seborrhea-Like Dermatitis with Psoriasiform Elements

ClinVar genetic disease variations for Seborrhea-Like Dermatitis with Psoriasiform Elements:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 TBCD , ZNF750 NM_024702.3(ZNF750):c.55_56dup (p.Gly20fs) Duplication Pathogenic 1295 rs1322527075 GRCh37: 17:80790274-80790275
GRCh38: 17:82832398-82832399

Expression for Seborrhea-Like Dermatitis with Psoriasiform Elements

Search GEO for disease gene expression data for Seborrhea-Like Dermatitis with Psoriasiform Elements.

Pathways for Seborrhea-Like Dermatitis with Psoriasiform Elements

GO Terms for Seborrhea-Like Dermatitis with Psoriasiform Elements

Sources for Seborrhea-Like Dermatitis with Psoriasiform Elements

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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