MCID: SBR001
MIFTS: 39

Seborrheic Infantile Dermatitis

Categories: Skin diseases

Aliases & Classifications for Seborrheic Infantile Dermatitis

MalaCards integrated aliases for Seborrheic Infantile Dermatitis:

Name: Seborrheic Infantile Dermatitis 12 15
Cradle Cap 12 73
Generalized Seborrheic Dermatitis of Infants 12
Complement Component 5 Deficiency 73
Infantile Seborrhoeic Dermatitis 12
Infantile Seborrheic Dermatitis 12
Seborrhoeic Dermatitis of Scalp 12
Seborrheic Dermatitis of Scalp 73
Seborrhoeic Eczema of Scalp 12
Complement 5 Dysfunction 12
Seborrheic Dermatitis 73
Scurfiness of Scalp 73
Pityriasis Capitis 12
Seborrhoea Capitis 12
Seborrhea Capitis 12
Seborrhea Sicca 12
Dandruff 44

Classifications:



Summaries for Seborrheic Infantile Dermatitis

Disease Ontology : 12 A seborrheic dermatitis that involves fungal infection of the scalp of recently born babies caused by Malassezia furfur. It is occasionally linked to immune disorders. The symptoms include thick, crusty, yellow or brown scales over the child's scalp.

MalaCards based summary : Seborrheic Infantile Dermatitis, also known as cradle cap, is related to dermatitis, atopic and dermatitis. An important gene associated with Seborrheic Infantile Dermatitis is TECR (Trans-2,3-Enoyl-CoA Reductase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and PAK Pathway. The drugs Dermatologic Agents and Emollients have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and skin.

Related Diseases for Seborrheic Infantile Dermatitis

Diseases in the Seborrheic Dermatitis family:

Seborrheic Infantile Dermatitis

Diseases related to Seborrheic Infantile Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 dermatitis, atopic 29.2 CSF2 IL5
2 dermatitis 10.2
3 seborrheic dermatitis 10.2
4 felty syndrome 10.0 CSF2 IL3
5 cyclic neutropenia 10.0 CSF2 IL3
6 anemia of prematurity 10.0 CSF2 IL3
7 lymphoma, hodgkin, classic 10.0 CSF2 IL3
8 thrombocytosis 10.0 CSF2 IL3
9 pancytopenia 9.9 CSF2 IL3
10 megakaryocytic leukemia 9.9 CSF2 IL3
11 severe congenital neutropenia 9.9 CSF2 IL3
12 diphtheria 9.9 CSF2 IL3
13 bone marrow cancer 9.8 CSF2 IL3
14 neutropenia 9.8 CSF2 IL3
15 chronic tic disorder 9.8 CSF2 IL5
16 leukemia, chronic myeloid 9.7 CSF2 IL3
17 bronchial disease 9.7 CSF2 IL5
18 intrinsic asthma 9.7 IL3 IL5
19 respiratory system disease 9.7 CSF2 IL5
20 atopic keratoconjunctivitis 9.7 IL3 IL5
21 hypereosinophilic syndrome, idiopathic 9.7 IL3 IL5
22 diamond-blackfan anemia 9.7 CSF2 IL3
23 eosinophilic gastritis 9.7 IL3 IL5
24 pollen allergy 9.6 IL3 IL5
25 keratoconjunctivitis 9.6 IL3 IL5
26 lymphoma, non-hodgkin, familial 9.6 CSF2 IL3
27 lung disease 9.6 CSF2 IL5
28 hematologic cancer 9.5 CSF2 IL3
29 aplastic anemia 9.2 CSF2 IL3
30 eosinophilic gastroenteritis 9.1 CSF2 IL3 IL5
31 eosinophilic pneumonia 9.1 CSF2 IL3 IL5
32 leukocyte disease 9.1 CSF2 IL3 IL5
33 immune system disease 9.1 CSF2 IL3 IL5
34 hypereosinophilic syndrome 9.1 CSF2 IL3 IL5
35 asthma 8.9 CSF2 IL3 IL5

Comorbidity relations with Seborrheic Infantile Dermatitis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Seborrheic Infantile Dermatitis:



Diseases related to Seborrheic Infantile Dermatitis

Symptoms & Phenotypes for Seborrheic Infantile Dermatitis

Drugs & Therapeutics for Seborrheic Infantile Dermatitis

Drugs for Seborrheic Infantile Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Dermatologic Agents Phase 4
2 Emollients Phase 4
3
rituximab Approved Phase 2 174722-31-7 10201696
4
Gemcitabine Approved Phase 2 95058-81-4 60750
5
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
6
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
7
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
8
Trametinib Approved Phase 2 871700-17-3 11707110
9 Alkylating Agents Phase 2
10 Complement System Proteins Phase 2
11 Nitrogen Mustard Compounds Phase 2
12 Immunoglobulin G Phase 2
13 Antibodies Phase 2,Phase 1
14 Immunoglobulins Phase 2,Phase 1
15 Antibodies, Monoclonal Phase 2,Phase 1
16 Protein Kinase Inhibitors Phase 2
17 Bendamustine Hydrochloride Phase 2
18 Antineoplastic Agents, Alkylating Phase 2
19
Everolimus Approved Phase 1 159351-69-6 6442177
20
Sirolimus Approved, Investigational Phase 1 53123-88-9 5284616 6436030 46835353
21
Coal tar Approved Phase 1 8007-45-2
22
Oxaliplatin Approved, Investigational Phase 1 61825-94-3 5310940 9887054 43805 6857599
23
Bevacizumab Approved, Investigational Phase 1 216974-75-3
24
nivolumab Approved Phase 1 946414-94-4
25
Trifluridine Approved, Investigational Phase 1 70-00-8 6256
26
Vitamin A Approved, Nutraceutical, Vet_approved Phase 1 11103-57-4, 68-26-8 445354
27 Angiogenesis Inhibitors Phase 1
28 Angiogenesis Modulating Agents Phase 1
29 Pharmaceutical Solutions Phase 1
30 Anti-Infective Agents Phase 1
31 Antimetabolites Phase 1
32 Antiviral Agents Phase 1
33 interferons Phase 1
34 Vaccines Phase 1
35 Antibodies, Blocking Phase 1
36 Poly I-C Phase 1
37 Poly ICLC Phase 1
38 Interferon Inducers Phase 1
39 Retinol palmitate Phase 1
40 tyrosine Nutraceutical Phase 1
41 retinol Nutraceutical Phase 1
42 Complement C3 Not Applicable
43 fucoidan Not Applicable
44 Gastrointestinal Agents Not Applicable
45 Antacids Not Applicable
46 Anticoagulants Not Applicable
47 Anti-Ulcer Agents Not Applicable

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Promiseb Topical Cream for Cradle Cap Completed NCT01214434 Phase 4
2 Open-label Study to Evaluate the Safety, PK, and PD of MEK Inhibitor GSK1120212 in Subjects With Relapsed or Refractory Leukemias Completed NCT00920140 Phase 2 GSK1120212;GSK1120212
3 Safety and Efficacy Study for Solid Tumor Patients Treated With Eltrombopag Completed NCT01147809 Phase 2 Eltrombopag olamine
4 Ofatumumab Plus Bendamustine in Frontline and Relapsed Chronic Lymphocytic Leukaemia (CLL) Completed NCT01520922 Phase 2 Bendamustine
5 Study Of Ispinesib In Subjects With Breast Cancer Completed NCT00089973 Phase 2 Ispinesib
6 Study of ARQ 092 in Patients With Overgrowth Diseases and/or Vascular Anomalies Recruiting NCT03094832 Phase 1, Phase 2 ARQ 092
7 A Trial To Assess Safety And Tolerability Of PF-04691502 In Cancer Patients Completed NCT00927823 Phase 1 PF-04691502
8 Escalating Dose Study in Subjects With Relapsed or Refractory B Cell Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, and Waldenstrom's Macroglobulinemia Completed NCT01351935 Phase 1 AVL-292
9 Study of S 95005 in Combination With Oxaliplatin in Metastatic Colorectal Cancer Recruiting NCT02848443 Phase 1 Trifluridine/tipiracil hydrochloride (S 95005);Oxaliplatin;Bevacizumab;Nivolumab
10 Neoantigen-based Personalized Vaccine Combined With Immune Checkpoint Blockade Therapy in Patients With Newly Diagnosed, Unmethylated Glioblastoma Not yet recruiting NCT03422094 Phase 1
11 Clinical Study of Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL) Suspended NCT02117336 Phase 1 P1446A-05
12 Minimal Residual Disease in Peripheral T-cell Lymphoma Recruiting NCT03297697 Not Applicable
13 To Evaluate the QoL Improvement of Oral Oligo Fucoidan in Subjects Receiving Platinum-based Chemotherapy With NSCLC Not yet recruiting NCT03130829 Not Applicable

Search NIH Clinical Center for Seborrheic Infantile Dermatitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: dandruff

Genetic Tests for Seborrheic Infantile Dermatitis

Anatomical Context for Seborrheic Infantile Dermatitis

MalaCards organs/tissues related to Seborrheic Infantile Dermatitis:

41
B Cells, T Cells, Skin

Publications for Seborrheic Infantile Dermatitis

Articles related to Seborrheic Infantile Dermatitis:

# Title Authors Year
1
Infantile seborrheic dermatitis: a pediatric Siddha medicine treatise. ( 25889138 )
2015
2
Utilization of matrix-assisted laser desorption and ionization time-of-flight mass spectrometry for identification of infantile seborrheic dermatitis-causing Malassezia and incidence of culture-based cutaneous Malassezia microbiota of 1-month-old infants. ( 24387229 )
2014
3
Retrospective Analysis of the Relationship Between Infantile Seborrheic Dermatitis and Atopic Dermatitis. ( 24224924 )
2013
4
Comparative study of 2% ketoconazole cream and 1% hydrocortisone cream in the treatment of infantile seborrheic dermatitis. ( 16083165 )
2004

Variations for Seborrheic Infantile Dermatitis

Expression for Seborrheic Infantile Dermatitis

Search GEO for disease gene expression data for Seborrheic Infantile Dermatitis.

Pathways for Seborrheic Infantile Dermatitis

Pathways related to Seborrheic Infantile Dermatitis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 CSF2 IL3 IL5
2
Show member pathways
12.75 CSF2 IL3 IL5
3
Show member pathways
12.18 CSF2 IL3 IL5
4
Show member pathways
12.14 CSF2 IL3 IL5
5
Show member pathways
11.87 CSF2 IL5
6 11.76 CSF2 IL3
7
Show member pathways
11.73 CSF2 IL3 IL5
8 11.56 CSF2 IL3 IL5
9 11.42 CSF2 IL3 IL5
10 11.39 CSF2 IL5
11 11.26 CSF2 IL5
12
Show member pathways
11.21 CSF2 IL3 IL5
13 10.81 CSF2 IL3 IL5
14 10.28 CSF2 IL3 IL5

GO Terms for Seborrheic Infantile Dermatitis

Biological processes related to Seborrheic Infantile Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.61 CSF2 IL3 IL5
2 immune response GO:0006955 9.58 CSF2 IL3 IL5
3 regulation of signaling receptor activity GO:0010469 9.54 CSF2 IL3 IL5
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.48 IL3 IL5
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.46 CSF2 IL3
6 cytokine-mediated signaling pathway GO:0019221 9.43 CSF2 IL3 IL5
7 MAPK cascade GO:0000165 9.33 CSF2 IL3 IL5
8 positive regulation of DNA replication GO:0045740 9.32 CSF2 IL3
9 positive regulation of podosome assembly GO:0071803 8.96 CSF2 IL5
10 peptidyl-tyrosine phosphorylation GO:0018108 8.8 CSF2 IL3 IL5

Molecular functions related to Seborrheic Infantile Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 CSF2 IL3 IL5
2 protein tyrosine kinase activity GO:0004713 9.33 CSF2 IL3 IL5
3 growth factor activity GO:0008083 9.13 CSF2 IL3 IL5
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.8 CSF2 IL3 IL5

Sources for Seborrheic Infantile Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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