MCID: SBR001
MIFTS: 40

Seborrheic Infantile Dermatitis

Categories: Skin diseases

Aliases & Classifications for Seborrheic Infantile Dermatitis

MalaCards integrated aliases for Seborrheic Infantile Dermatitis:

Name: Seborrheic Infantile Dermatitis 12 15
Cradle Cap 12 73
Generalized Seborrheic Dermatitis of Infants 12
Complement Component 5 Deficiency 73
Infantile Seborrhoeic Dermatitis 12
Infantile Seborrheic Dermatitis 12
Seborrhoeic Dermatitis of Scalp 12
Seborrheic Dermatitis of Scalp 73
Seborrhoeic Eczema of Scalp 12
Complement 5 Dysfunction 12
Seborrheic Dermatitis 73
Scurfiness of Scalp 73
Pityriasis Capitis 12
Seborrhoea Capitis 12
Seborrhea Capitis 12
Seborrhea Sicca 12
Dandruff 44

Classifications:



External Ids:

Disease Ontology 12 DOID:8941
ICD10 33 L21.0 L21.1
ICD9CM 35 690.11
MeSH 44 D063807

Summaries for Seborrheic Infantile Dermatitis

Disease Ontology : 12 A seborrheic dermatitis that involves fungal infection of the scalp of recently born babies caused by Malassezia furfur. It is occasionally linked to immune disorders. The symptoms include thick, crusty, yellow or brown scales over the child's scalp.

MalaCards based summary : Seborrheic Infantile Dermatitis, also known as cradle cap, is related to dermatitis, atopic and dermatitis. An important gene associated with Seborrheic Infantile Dermatitis is TECR (Trans-2,3-Enoyl-CoA Reductase), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Response to elevated platelet cytosolic Ca2+. The drugs Emollients and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and lung.

Related Diseases for Seborrheic Infantile Dermatitis

Diseases in the Seborrheic Dermatitis family:

Seborrheic Infantile Dermatitis

Diseases related to Seborrheic Infantile Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 dermatitis, atopic 29.8 CSF2 IL5
2 dermatitis 10.3
3 seborrheic dermatitis 10.3
4 pyoderma 10.2
5 blepharitis 10.2
6 skin conditions 10.1
7 felty syndrome 10.0 CSF2 IL3
8 skin disease 10.0
9 psoriasis 10.0
10 granulocytopenia 10.0 CSF2 IL3
11 cyclic neutropenia 10.0 CSF2 IL3
12 neutropenia 10.0 CSF2 IL3
13 anemia of prematurity 10.0 CSF2 IL3
14 thrombocytosis 10.0 CSF2 IL3
15 pancytopenia 10.0 CSF2 IL3
16 megakaryocytic leukemia 10.0 CSF2 IL3
17 severe congenital neutropenia 10.0 CSF2 IL3
18 diphtheria 10.0 CSF2 IL3
19 sarcoidosis 1 10.0 CSF2 IL3
20 bone marrow cancer 9.9 CSF2 IL3
21 leukemia, chronic myeloid 9.9 CSF2 IL3
22 chronic tic disorder 9.9 CSF2 IL5
23 diamond-blackfan anemia 9.9 CSF2 IL3
24 bronchial disease 9.9 CSF2 IL5
25 hypereosinophilic syndrome, idiopathic 9.9 IL3 IL5
26 aspergillosis 9.9 CSF2 IL5
27 atopic keratoconjunctivitis 9.9 IL3 IL5
28 keratoconjunctivitis 9.9 IL3 IL5
29 intrinsic asthma 9.9 IL3 IL5
30 eosinophilic gastroenteritis 9.9 IL3 IL5
31 eosinophilic gastritis 9.9 IL3 IL5
32 respiratory system disease 9.9 CSF2 IL5
33 pollen allergy 9.9 IL3 IL5
34 respiratory allergy 9.9 IL3 IL5
35 hematologic cancer 9.9 CSF2 IL3
36 allergic hypersensitivity disease 9.8 IL3 IL5
37 lung disease 9.8 CSF2 IL5
38 lymphoma, non-hodgkin, familial 9.8 CSF2 IL3
39 aplastic anemia 9.8 CSF2 IL3
40 eosinophilic pneumonia 9.7 CSF2 IL3 IL5
41 leukocyte disease 9.7 CSF2 IL3 IL5
42 hypereosinophilic syndrome 9.7 CSF2 IL3 IL5
43 asthma 9.7 CSF2 IL3 IL5

Comorbidity relations with Seborrheic Infantile Dermatitis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Seborrheic Infantile Dermatitis:



Diseases related to Seborrheic Infantile Dermatitis

Symptoms & Phenotypes for Seborrheic Infantile Dermatitis

Drugs & Therapeutics for Seborrheic Infantile Dermatitis

Drugs for Seborrheic Infantile Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Emollients Phase 4
2 Dermatologic Agents Phase 4
3
Trametinib Approved Phase 2 871700-17-3 11707110
4
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
5
Gemcitabine Approved Phase 2 95058-81-4 60750
6
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
7
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
8
rituximab Approved Phase 2 174722-31-7 10201696
9
Ofatumumab Approved Phase 2 679818-59-8 6918251
10
Tremelimumab Investigational Phase 2 745013-59-6
11 Protein Kinase Inhibitors Phase 2
12 Complement System Proteins Phase 2
13 Antibodies, Monoclonal Phase 2,Phase 1
14 Immunologic Factors Phase 2,Phase 1
15 Immunoglobulin G Phase 2
16 Nitrogen Mustard Compounds Phase 2
17 Bendamustine Hydrochloride Phase 2
18 Alkylating Agents Phase 2
19 Antibodies Phase 2,Phase 1
20 Immunoglobulins Phase 2,Phase 1
21 Antineoplastic Agents, Alkylating Phase 2
22 Complement C3 Phase 2
23 Vaccines Phase 2,Phase 1
24
Everolimus Approved Phase 1 159351-69-6 6442177
25
Sirolimus Approved, Investigational Phase 1 53123-88-9 46835353 6436030 5284616
26
Coal tar Approved Phase 1 8007-45-2
27
Nivolumab Approved Phase 1 946414-94-4
28
Oxaliplatin Approved, Investigational Phase 1 61825-94-3 43805 6857599 5310940 9887054
29
Bevacizumab Approved, Investigational Phase 1 216974-75-3
30
Trifluridine Approved, Investigational Phase 1 70-00-8 6256
31
Vitamin A Approved, Nutraceutical, Vet_approved Phase 1 11103-57-4, 68-26-8 445354
32 tyrosine Phase 1
33 interferons Phase 1
34 Antibodies, Blocking Phase 1
35 Poly I-C Phase 1
36 Poly ICLC Phase 1
37 Interferon Inducers Phase 1
38 Antiviral Agents Phase 1
39 Pharmaceutical Solutions Phase 1
40 Angiogenesis Modulating Agents Phase 1
41 Antimetabolites Phase 1
42 Anti-Infective Agents Phase 1
43 Angiogenesis Inhibitors Phase 1
44 Retinol palmitate Phase 1
45 retinol Phase 1
46 Antacids Not Applicable
47 Anticoagulants Not Applicable
48 Gastrointestinal Agents Not Applicable
49 Anti-Ulcer Agents Not Applicable
50 fucoidan Not Applicable

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Promiseb Topical Cream for Cradle Cap Completed NCT01214434 Phase 4
2 Open-label Study to Evaluate the Safety, PK, and PD of MEK Inhibitor GSK1120212 in Subjects With Relapsed or Refractory Leukemias Completed NCT00920140 Phase 2 GSK1120212;GSK1120212
3 Safety and Efficacy Study for Solid Tumor Patients Treated With Eltrombopag Completed NCT01147809 Phase 2 Eltrombopag olamine
4 Ofatumumab Plus Bendamustine in Frontline and Relapsed Chronic Lymphocytic Leukaemia (CLL) Completed NCT01520922 Phase 2 Bendamustine
5 Study Of Ispinesib In Subjects With Breast Cancer Completed NCT00089973 Phase 2 Ispinesib
6 PolyImmune {Durvalumab (MEDI4736) and Tremelimumab} & Vaccine Orchestrated Treatment for Patients With Advanced/Metastatic Renal Cell Carcinoma Not yet recruiting NCT03598816 Phase 2 Durvalumab;Tremelimumab
7 A Trial To Assess Safety And Tolerability Of PF-04691502 In Cancer Patients Completed NCT00927823 Phase 1 PF-04691502
8 Escalating Dose Study in Subjects With Relapsed or Refractory B Cell Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, and Waldenstrom's Macroglobulinemia Completed NCT01351935 Phase 1 AVL-292
9 Neoantigen-based Personalized Vaccine Combined With Immune Checkpoint Blockade Therapy in Patients With Newly Diagnosed, Unmethylated Glioblastoma Recruiting NCT03422094 Phase 1
10 Study of S 95005 in Combination With Oxaliplatin in Metastatic Colorectal Cancer Recruiting NCT02848443 Phase 1 Trifluridine/tipiracil hydrochloride (S 95005);Oxaliplatin;Bevacizumab;Nivolumab
11 Clinical Study of Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL) Suspended NCT02117336 Phase 1 P1446A-05
12 Minimal Residual Disease in Peripheral T-cell Lymphoma Recruiting NCT03297697
13 To Evaluate the QoL Improvement of Oral Oligo Fucoidan in Subjects Receiving Platinum-based Chemotherapy With NSCLC Not yet recruiting NCT03130829 Not Applicable

Search NIH Clinical Center for Seborrheic Infantile Dermatitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: dandruff

Genetic Tests for Seborrheic Infantile Dermatitis

Anatomical Context for Seborrheic Infantile Dermatitis

MalaCards organs/tissues related to Seborrheic Infantile Dermatitis:

41
Skin, Bone, Lung, Myeloid, Bone Marrow

Publications for Seborrheic Infantile Dermatitis

Articles related to Seborrheic Infantile Dermatitis:

(show all 12)
# Title Authors Year
1
Recurrent Vulvar Ulcers and "Cradle Cap" in a 2-Year-Old. ( 30322698 )
2018
2
Cradle cap. ( 24986302 )
2014
3
Topical, Non-Medicated LOYON(®) in Facilitating the Removal of Scaling in Infants and Children with Cradle Cap: a Proof-of-Concept Pilot Study. ( 25119137 )
2014
4
A double-blind, placebo-controlled pilot study to estimate the efficacy and tolerability of a nonsteroidal cream for the treatment of cradle cap (seborrheic dermatitis). ( 23652893 )
2013
5
Olive oil for cradle cap? ( 21121479 )
2010
6
Clinical inquiries. What's the best treatment for cradle cap? ( 17343816 )
2007
7
On top of cradle cap. ( 17824212 )
2007
8
The frequency of common skin conditions in preschool-aged children in Australia: seborrheic dermatitis and pityriasis capitis (cradle cap). ( 12622623 )
2003
9
Infantile seborrheic dermatitis: an approach to cradle cap. ( 8477601 )
1993
10
Cradle cap. ( 2138530 )
1990
11
A TREATMENT FOR SEBORRHEA CAPITIS (CRADLE CAP). ( 14118686 )
1964
12
A new treatment for cradle cap. ( 13388073 )
1957

Variations for Seborrheic Infantile Dermatitis

Expression for Seborrheic Infantile Dermatitis

Search GEO for disease gene expression data for Seborrheic Infantile Dermatitis.

Pathways for Seborrheic Infantile Dermatitis

Pathways related to Seborrheic Infantile Dermatitis according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 CSF2 IL3 IL5
2
Show member pathways
12.8 CSF2 IL3 IL5
3
Show member pathways
12.78 CSF2 IL3 IL5
4
Show member pathways
12.16 CSF2 IL3 IL5
5
Show member pathways
11.97 CSF2 IL3 IL5
6
Show member pathways
11.89 CSF2 IL5
7 11.79 CSF2 IL3
8
Show member pathways
11.73 CSF2 IL3 IL5
9 11.56 CSF2 IL3 IL5
10 11.42 CSF2 IL5
11 11.42 CSF2 IL3 IL5
12 11.28 CSF2 IL5
13
Show member pathways
11.21 CSF2 IL3 IL5
14 10.81 CSF2 IL3 IL5
15 10.81 CSF2 IL3 IL5
16 10.57 CSF2 IL3 IL5
17 10.26 CSF2 IL3 IL5

GO Terms for Seborrheic Infantile Dermatitis

Biological processes related to Seborrheic Infantile Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.58 CSF2 IL3 IL5
2 immune response GO:0006955 9.54 CSF2 IL3 IL5
3 regulation of signaling receptor activity GO:0010469 9.5 CSF2 IL3 IL5
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.46 IL3 IL5
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.43 CSF2 IL3
6 cytokine-mediated signaling pathway GO:0019221 9.43 CSF2 IL3 IL5
7 MAPK cascade GO:0000165 9.33 CSF2 IL3 IL5
8 positive regulation of podosome assembly GO:0071803 8.96 CSF2 IL5
9 peptidyl-tyrosine phosphorylation GO:0018108 8.8 CSF2 IL3 IL5

Molecular functions related to Seborrheic Infantile Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 CSF2 IL3 IL5
2 growth factor activity GO:0008083 9.33 CSF2 IL3 IL5
3 protein tyrosine kinase activity GO:0004713 9.13 CSF2 IL3 IL5
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.8 CSF2 IL3 IL5

Sources for Seborrheic Infantile Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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