MCID: SCN049
MIFTS: 27

Second-Degree Atrioventricular Block

Categories: Cardiovascular diseases

Aliases & Classifications for Second-Degree Atrioventricular Block

MalaCards integrated aliases for Second-Degree Atrioventricular Block:

Name: Second-Degree Atrioventricular Block 12 15
Second Degree Atrioventricular Block 73
Second-Degree Heart Block 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050822
ICD10 33 I44.1
UMLS 73 C0264906

Summaries for Second-Degree Atrioventricular Block

MalaCards based summary : Second-Degree Atrioventricular Block, also known as second degree atrioventricular block, is related to atrioventricular block and type i. An important gene associated with Second-Degree Atrioventricular Block is WDR62 (WD Repeat Domain 62). The drugs rituximab and Alkylating Agents have been mentioned in the context of this disorder. Affiliated tissues include heart and testes.

Wikipedia : 76 Second-degree atrioventricular block (AV block) is a disease of the electrical conduction system of the... more...

Related Diseases for Second-Degree Atrioventricular Block

Diseases related to Second-Degree Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 atrioventricular block 10.7
2 type i 10.3
3 progressive familial heart block, type ia 10.2
4 progressive familial heart block, type ib 10.2
5 right bundle branch block 10.2
6 atrial standstill 1 10.1
7 myocardial infarction 10.1
8 third-degree atrioventricular block 10.1
9 aging 9.9
10 anorexia nervosa 9.9
11 acute myocardial infarction 9.9
12 lymphoma 9.9
13 epilepsy 9.9
14 long qt syndrome 9.9
15 mixed connective tissue disease 9.9
16 hypokalemia 9.9
17 septal myocardial infarction 9.9
18 connective tissue disease 9.9
19 trichinosis 9.9
20 hypertonia 9.9
21 syncope 9.9
22 angina pectoris 9.9
23 ehrlichiosis 9.9
24 aseptic meningitis 9.9
25 meningitis 9.9

Graphical network of the top 20 diseases related to Second-Degree Atrioventricular Block:



Diseases related to Second-Degree Atrioventricular Block

Symptoms & Phenotypes for Second-Degree Atrioventricular Block

Drugs & Therapeutics for Second-Degree Atrioventricular Block

Drugs for Second-Degree Atrioventricular Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 3 174722-31-7 10201696
2 Alkylating Agents Phase 3
3 Antineoplastic Agents, Alkylating Phase 3
4 Antirheumatic Agents Phase 3
5 Bendamustine Hydrochloride Phase 3
6
Acetaminophen Approved Phase 2 103-90-2 1983
7
Codeine Approved, Illicit Phase 2 76-57-3 5284371
8
Guaifenesin Approved, Investigational, Vet_approved Phase 2 93-14-1 3516
9
Adenosine Approved, Investigational Phase 2 58-61-7 60961
10 Analgesics Phase 2
11 Analgesics, Non-Narcotic Phase 2
12 Analgesics, Opioid Phase 2
13 Antipyretics Phase 2
14 Antitussive Agents Phase 2
15 Central Nervous System Depressants Phase 2
16 Chlorpheniramine, phenylpropanolamine drug combination Phase 2
17 Narcotics Phase 2
18 Peripheral Nervous System Agents Phase 2
19 Respiratory System Agents Phase 2
20 Adenosine A1 Receptor Agonists Phase 2
21 Neurotransmitter Agents Phase 2
22 Pharmaceutical Solutions Phase 2
23
Estradiol Approved, Investigational, Vet_approved Phase 1 50-28-2 5757
24 Estradiol valerate Approved, Investigational, Vet_approved Phase 1 979-32-8
25
Ethinyl Estradiol Approved Phase 1 57-63-6 5991
26
Moxifloxacin Approved, Investigational Phase 1 354812-41-2, 151096-09-2 152946
27
Norgestimate Approved, Investigational Phase 1 35189-28-7 6540478
28
Polyestradiol phosphate Approved Phase 1 28014-46-2
29
Macitentan Approved Phase 1 441798-33-0
30
Oxymetazoline Approved, Investigational Phase 1 1491-59-4 4636
31
Phenylephrine Approved Phase 1 59-42-7 6041
32 Anti-Bacterial Agents Phase 1
33 Anti-Infective Agents Phase 1
34 Contraceptive Agents Phase 1
35 Contraceptives, Oral Phase 1
36 Contraceptives, Oral, Combined Phase 1
37 Estradiol 17 beta-cypionate Phase 1
38 Estradiol 3-benzoate Phase 1
39 Fluoroquinolones Phase 1
40 Norgestimate, ethinyl estradiol drug combination Phase 1
41 Nucleic Acid Synthesis Inhibitors Phase 1
42 Topoisomerase Inhibitors Phase 1
43 Endothelin A Receptor Antagonists Phase 1
44 Endothelin Receptor Antagonists Phase 1
45
Lacosamide Approved 860352-01-8, 175481-36-4 219078
46 Anticonvulsants

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Cardiac Sarcoidosis Response To Steroids Trial Withdrawn NCT01210677 Phase 4 Prednisone
2 Study to Assess the Effect of Treatment With Bendamustine in Combination With Rituximab on QT Interval in Patients With Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL) Completed NCT01073163 Phase 3 Bendamustine;Rituximab
3 SB-705498 Dental Pain Study After Tooth Extraction Completed NCT00281684 Phase 2 SB705498 400 mg;SB705498 1000 mg;Placebo;Co-Codamol
4 Multiple Dose Study in Heart Failure of BAY 1067197 Completed NCT02040233 Phase 2 BAY1067197 (10 mg);BAY1067197;Placebo (10 mg);Placebo
5 Efficacy, Safety and Tolerability of BAF312 Compared to Placebo in Patients With Intracerebral Hemorrhage (ICH). Recruiting NCT03338998 Phase 2 BAF312;Placebo
6 Trial to Evaluate the Effects of OPC-34712 on QT/QTc in Subjects With Schizophrenia or Schizoaffective Disorder Completed NCT01423916 Phase 1 OPC-34712 (4mg);Moxifloxacin;OPC-34712 (12mg);Placebo
7 Study to Assess the Effect of Macitentan on the Electrocardiogram (ECG) in Healthy Male and Female Subjects Completed NCT02050802 Phase 1 Moxifloxacin 400 mg;Macitentan 10 mg;Macitentan 30 mg
8 HV Electrophysiology Study In Transcatheter Aortic Valve Implantation Patients Unknown status NCT02659137
9 Post-Authorization Safety Study to Assess the Safety of Vimpat as add-on Therapy in Patients With Partial-onset Seizures Completed NCT00771927 Lacosamide
10 Zero-fluoroscopic Navigation Versus Conventional Fluoroscopic Navigation for Single-chamber Pacemaker Implantation Recruiting NCT03118440 Not Applicable
11 Zero-fluoroscopic Navigation Versus Conventional Fluoroscopic Navigation for Double-chamber Pacemaker Implantation Recruiting NCT03118427 Not Applicable
12 Bifocal Right Ventricular PAcing in Right Bundle Branch blocK and Heart Failure With Reduced Ejection Fraction. The Study Tests the Superiority of Right Ventricular Bifocal Stimulation Over VVI Implantable Defibrillator in Right Bundle Branch Block and He Recruiting NCT03524001 Not Applicable

Search NIH Clinical Center for Second-Degree Atrioventricular Block

Genetic Tests for Second-Degree Atrioventricular Block

Anatomical Context for Second-Degree Atrioventricular Block

MalaCards organs/tissues related to Second-Degree Atrioventricular Block:

41
Heart, Testes

Publications for Second-Degree Atrioventricular Block

Articles related to Second-Degree Atrioventricular Block:

(show all 35)
# Title Authors Year
1
Second-degree Atrioventricular Block: Conceptions and Misconceptions. ( 29977560 )
2018
2
Computed tomography is important in appropriately diagnosing patients with third-degree atrioventricular block and second-degree atrioventricular block but not Wenckebach type. ( 27886613 )
2017
3
Successful prenatal management of ventricular tachycardia and second-degree atrioventricular block in fetal long QT syndrome. ( 28491768 )
2017
4
A second-degree atrioventricular block with double escape rhythm secondary to paroxysmal vagal hypertonia. ( 28857928 )
2017
5
Hisian extrasystole mimicking second degree atrioventricular block. a case report. ( 29424877 )
2017
6
Mobitz type 1 second-degree atrioventricular block by triazolam and brotizolam overdose. ( 29123752 )
2016
7
A case of advanced second-degree atrioventricular block in a ferret secondary to lymphoma. ( 27200273 )
2016
8
Second-Degree Atrioventricular Block Occurring After Tooth Extraction. ( 27585419 )
2016
9
ECG Case of the Month: Unexpected Atrioventricular Conduction in High-Grade Atrioventricular Block. Sinus rhythm; high-grade second degree atrioventricular block with a junctional escape rhythm and three capture complexes, each with right bundle branch block aberration; possible septal myocardial infarct of indeterminate age; ST-T and U wave changes suggesting hypokalemia. ( 25978059 )
2015
10
Second-degree atrioventricular block type II and third-degree atrioventricular block requiring cardiac pacing after tooth extraction. ( 25914824 )
2015
11
Mobitz type II second-degree atrioventricular block during dobutamine stress echocardiography. True or false? ( 25080840 )
2014
12
Syncope secondary to second-degree atrioventricular block with donepezil use. ( 25484499 )
2014
13
Second-degree atrioventricular block. ( 25318341 )
2014
14
Mobitz type II second-degree atrioventricular block with narrow QRS and junctional extrasystoles: what is the mechanism? ( 24237845 )
2014
15
Long-term follow-up of older patients with Mobitz type I second degree atrioventricular block. ( 23086974 )
2013
16
Mobitz type 1 second degree atrioventricular block: the value of permanent pacing in the older patient. ( 23242834 )
2013
17
Exercise-induced second-degree atrioventricular block in endurance athletes. ( 23059863 )
2013
18
Second-degree atrioventricular block revisited. ( 23224264 )
2012
19
ECG of the Month. Second-degree atrioventricular block in a cat. ( 22852566 )
2012
20
Late occurrence of transient advanced second degree atrioventricular block after successful transcatheter cryoablation of atrioventricular nodal reentry tachycardia. ( 24826272 )
2012
21
Markedly varying PR intervals during second degree atrioventricular block: possible mechanisms. ( 22664821 )
2012
22
Mobitz type II second-degree atrioventricular block in athletes: true or false? ( 18801768 )
2011
23
Lacosamide-induced second-degree atrioventricular block in a patient with partial epilepsy. ( 21801173 )
2011
24
A rare cause of trauma in the elderly: Mobitz type-II second-degree atrioventricular block. ( 22166702 )
2011
25
Type I second-degree atrioventricular block and intermittent left posterior fascicular block in a 26-year-old woman with an inferoposterior acute myocardial infarct. ( 21240299 )
2009
26
Ecg of the month. Arrhythmia on an ambulatory electrocardiogram. Sinus rhythm with second degree atrioventricular block, type I (Wenckebach); non-conducted atrial premature complexes; and concealed conduction of the fourth sinus P wave into atrioventricular junction. ( 19489387 )
2009
27
Second-degree atrioventricular block (Mobitz Type I) in an adolescent with anorexia nervosa: intrinsic or acquired conduction abnormality. ( 19189406 )
2009
28
Second degree atrioventricular block Mobitz type I after administration of benzathine penicillin: case report. ( 19488534 )
2009
29
Persistent second-degree atrioventricular block following adenosine infusion for nuclear stress testing. ( 18301154 )
2008
30
Second-degree atrioventricular block as the first sign of sarcoidosis in a previously asymptomatic patient. ( 17608106 )
2007
31
Identifying second-degree atrioventricular block (type I). ( 18046202 )
2007
32
Right bundle branch block and second-degree atrioventricular block: what is the mechanism? ( 15851328 )
2005
33
[Second degree atrioventricular block in mixed connective tissue disease]. ( 15925432 )
2005
34
ECG of the month. Slow bigeminal rhythm. Low atrial or junctional rhythm, second degree atrioventricular block, right ventricular escape beats, ventricular escape-capture bigeminy, ventriculophasic atrial arrhythmia, and right bundle branch block. ( 15366342 )
2004
35
Second degree atrioventricular block in acute trichinosis. ( 5080690 )
1972

Variations for Second-Degree Atrioventricular Block

Expression for Second-Degree Atrioventricular Block

Search GEO for disease gene expression data for Second-Degree Atrioventricular Block.

Pathways for Second-Degree Atrioventricular Block

GO Terms for Second-Degree Atrioventricular Block

Sources for Second-Degree Atrioventricular Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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