MCID: SCN049
MIFTS: 35

Second-Degree Atrioventricular Block

Categories: Cardiovascular diseases

Aliases & Classifications for Second-Degree Atrioventricular Block

MalaCards integrated aliases for Second-Degree Atrioventricular Block:

Name: Second-Degree Atrioventricular Block 12 15
Second Degree Atrioventricular Block 71
Second-Degree Heart Block 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050822
ICD10 32 I44.1
UMLS 71 C0264906

Summaries for Second-Degree Atrioventricular Block

Disease Ontology : 12 An atrioventricular block that is characterized by progressive prolongation of the PR interval on consecutive beats followed by a blocked P wave on electrocardiogram or intermittently non-conducted P waves not preceded by PR changes on electrocardiogram caused by a conduction block between the atria and the ventricles through the atrioventricular node.

MalaCards based summary : Second-Degree Atrioventricular Block, also known as second degree atrioventricular block, is related to inferior myocardial infarction and atrioventricular block. An important gene associated with Second-Degree Atrioventricular Block is CA5B (Carbonic Anhydrase 5B), and among its related pathways/superpathways are cGMP-PKG signaling pathway and Ceramide Pathway. Affiliated tissues include heart, atrioventricular node and testes, and related phenotype is immune system.

Wikipedia : 74 Second-degree atrioventricular block (AV block) is a disease of the electrical conduction system of the... more...

Related Diseases for Second-Degree Atrioventricular Block

Diseases related to Second-Degree Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 inferior myocardial infarction 31.0 TNNI3 CA5B
2 atrioventricular block 31.0 TRIM21 TNNI3 SSB SCN5A HCN4 CA5B
3 first-degree atrioventricular block 30.5 TRIM44 SCN5A
4 left bundle branch hemiblock 30.3 TNNI3 SCN5A CA5B
5 right bundle branch block 30.2 TNNI3 SCN5A SCN3B HCN4 CA5B
6 sick sinus syndrome 30.2 SCN5A SCN3B HCN4
7 atrial heart septal defect 30.1 TNNI3 SCN5A HCN4
8 atrial standstill 1 30.1 TNNI3 TAZ SCN5A
9 wolff-parkinson-white syndrome 29.8 TRIM44 TNNI3 SCN5A HCN4
10 atrial fibrillation 29.7 TNNI3 SCN5A SCN3B HCN4
11 heart block, congenital 29.6 TRIM21 TAZ SSB CACNA1D
12 third-degree atrioventricular block 29.5 TRIM21 SSB SCN5A HCN4 CACNA1D CA5B
13 progressive familial heart block, type ia 10.7
14 syncope 10.5
15 progressive familial heart block, type ib 10.5
16 diffuse infiltrative lymphocytosis syndrome 10.4 TRIM21 SSB
17 familial sick sinus syndrome 10.3 SCN5A HCN4
18 mononeuritis of upper limb and mononeuritis multiplex 10.3 TRIM21 SSB
19 mononeuritis multiplex 10.3 TRIM21 SSB
20 acute myocardial infarction 10.3
21 parotid disease 10.3 TRIM21 SSB
22 polyclonal hypergammaglobulinemia 10.3 TRIM21 SSB
23 parotitis 10.3 TRIM21 SSB
24 xerophthalmia 10.3 TRIM21 SSB
25 cardiac conduction defect 10.2
26 sarcoidosis 1 10.2
27 anorexia nervosa 10.2
28 heart septal defect 10.2
29 long qt syndrome 10.2
30 hypokalemia 10.2
31 chronic kidney disease 10.2
32 myocarditis 10.2
33 mononeuropathy 10.2 TRIM21 SSB
34 cardiac arrhythmia 10.1
35 creatine phosphokinase, elevated serum 10.1
36 systemic lupus erythematosus 10.1
37 scleroderma, familial progressive 10.1
38 graves disease 1 10.1
39 cyanosis, transient neonatal 10.1
40 aortic valve disease 2 10.1
41 dermatomyositis 10.1
42 mobitz type ii atrioventricular block 10.1
43 pulmonary edema 10.1
44 lyme disease 10.1
45 graves' disease 10.1
46 dilated cardiomyopathy 10.1
47 cardiac sarcoidosis 10.1
48 ochronosis 10.1
49 ventricular septal defect 10.1
50 mitral valve stenosis 10.1

Graphical network of the top 20 diseases related to Second-Degree Atrioventricular Block:



Diseases related to Second-Degree Atrioventricular Block

Symptoms & Phenotypes for Second-Degree Atrioventricular Block

MGI Mouse Phenotypes related to Second-Degree Atrioventricular Block:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 IFNB1 MC3R PPP2R5A S1PR1 S1PR3 S1PR5

Drugs & Therapeutics for Second-Degree Atrioventricular Block

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cohort Description of Younger With AV-block Unknown status NCT03024047
2 Cardiac Computed Tomography In the Management of Patients With indeterminAte or inConclusive Stress Tests Completed NCT00541203

Search NIH Clinical Center for Second-Degree Atrioventricular Block

Genetic Tests for Second-Degree Atrioventricular Block

Anatomical Context for Second-Degree Atrioventricular Block

MalaCards organs/tissues related to Second-Degree Atrioventricular Block:

40
Heart, Atrioventricular Node, Testes, Colon, Kidney, Lung, Monocytes

Publications for Second-Degree Atrioventricular Block

Articles related to Second-Degree Atrioventricular Block:

(show top 50) (show all 485)
# Title Authors PMID Year
1
How to differentiate second-degree atrioventricular block from extrasystoles in fetuses with a bigeminal ventricular rhythm. 61
32323298 2020
2
Cardiac effects of repeated focal seizures in rats induced by intrahippocampal tetanus toxin: Bradyarrhythmias, tachycardias, and prolonged interictal QT interval. 61
32201948 2020
3
Dynamic changes in electrocardiograms of a premature infant with hyperkalemia and hypocalcemia. 61
32023498 2020
4
Second-degree atrioventricular block in an adolescent with an acute alcohol intoxication. 61
31708246 2020
5
Arrhythmias in Patients on Maintenance Dialysis: A Cross-sectional Study. 61
31542235 2020
6
[Increased Ventricular Pacing Threshold Caused by Intake of Dronedaron]. 61
32069492 2020
7
[Second-degree atrioventricular block caused by Lyme disease]. 61
32186826 2020
8
Pembrolizumab-Induced Mobitz Type 2 Second-Degree Atrioventricular Block. 61
32047674 2020
9
Heart Block Caused by Cardiac Metastasis From Merkel Cell Carcinoma: A Case Report. 61
31993571 2019
10
Severe Hypoglycemia-Induced Fatal Cardiac Arrhythmias Are Mediated by the Parasympathetic Nervous System in Rats. 61
31439645 2019
11
Analysis of cardiac monitoring and safety data in patients initiating fingolimod treatment in the home or in clinic. 61
31729968 2019
12
Severe transient neonatal long QT syndrome due to maternal paroxetine usage: a case report. 61
31475669 2019
13
Crataegus mexicana (Tejocote) Exposure Associated with Cardiotoxicity and a Falsely Elevated Digoxin Level. 61
31407210 2019
14
[Exploration of Mahuang Fuzi Xixin Decoction formula syndromes based on severe cases of critical care and its application for nosocomial infection in critical care medicine including hyperpyrexia after tracheotomy and severe pain accompanied by acute myocardial infarction and diabetic peripheral neuropathy]. 61
31872717 2019
15
Establishing 24-hour Holter reference intervals for clinically healthy puppies. 61
31325639 2019
16
Second degree heart block following the administration of dexmedetomidine. 61
30622043 2019
17
Frequency and characteristics of exercise-induced second-degree atrioventricular block in patients undergoing stress testing. 61
30925274 2019
18
Case report: Atrioventricular block after transcatheter atrial septal closure using the Figulla® Flex II ASD occluder. 61
30773790 2019
19
[Abnormal ECG findings in athletes]. 61
30920551 2019
20
Cardiac Arrhythmias in Horses. 61
30871832 2019
21
The influence of anesthesia with isoflurane on the pulmonary and aortic blood flow of Racing Pigeons (Columba livia f. domestica) measured by pulsed wave Doppler echocardiography. 61
31086761 2019
22
Lyme carditis presenting as atrial fibrillation. 61
31036741 2019
23
Advanced Heart Block in Children with Lyme Disease. 61
30377753 2019
24
Evaluation of heart rate variability and behavior of electrocardiographic parameters in dogs affected by chronic Monocytic Ehrlichiosis. 61
31125348 2019
25
Implantable loop recorders in patients with unexplained syncope: Clinical predictors of pacemaker implantation. 61
29399750 2019
26
Severe Cardiorespiratory and Neurologic Symptoms in a Neonate due to Mepivacaine Intoxication. 61
31428498 2019
27
Aripiprazole Overdose and Transient 2:1 Second Degree Atrioventricular Block: Only A Coincidence? 61
30659549 2019
28
Coma, Seizures, Atrioventricular Block, and Hypoglycemia in an ADB-FUBINACA Body-Packer. 61
30297193 2018
29
Short-Duration AL-335, Odalasvir, With or Without Simeprevir, in Patients With HCV GT1 or 3 Infection Without Cirrhosis. 61
30070722 2018
30
Resolution of fetal second-degree atrioventricular block. 61
30497753 2018
31
A 48-Year-Old Athletic Man With Bradycardia During Sleep. 61
30409368 2018
32
Dynamic Electrocardiography is Useful in the Diagnosis of Persistent Atrial Fibrillation Accompanied with Second-Degree Atrioventricular Block. 61
30271091 2018
33
Type I Second Degree Atrioventricular Block in a Woman With Remote Repair of a Ventricular Septal Defect. 61
30057230 2018
34
Acute Pediatric Colchicine Toxicity is Associated with Marked Bradydysrhythmias. 61
29685473 2018
35
Primary central sleep apnea and anesthesia: a retrospective case series. 61
29717414 2018
36
The analysis of the parameters of 24-hr ECG Holter monitoring in patients with blood neoplasms undergoing high-dose chemotherapy and stem cell transplantation. 61
29363852 2018
37
Glibenclamide Prevents Hypoglycemia-Induced Fatal Cardiac Arrhythmias in Rats. 61
29800118 2018
38
[One case of atrical ventricular dissociation and second degree atrioventricular block complcating with multiple episodes of ventricular tachycatdia]. 61
30032549 2018
39
Second-degree Atrioventricular Block: Conceptions and Misconceptions. 61
29977560 2018
40
Clinical and electrocardiographic presentations of transient trifascicular block in three cats. 61
29572123 2018
41
Efficacy and Safety of Subcutaneous Neostigmine for Ileus, Acute Colonic Pseudo-obstruction, or Refractory Constipation. 61
29359574 2018
42
Congenital second-degree heart block and total anomalous pulmonary venous return associated with microduplication of 1q32.2. 61
29922018 2018
43
Severe Hypoglycemia-Induced Fatal Cardiac Arrhythmias Are Augmented by Diabetes and Attenuated by Recurrent Hypoglycemia. 61
28887311 2017
44
Heart rate variability parameters in horses distinguish atrial fibrillation from sinus rhythm before and after successful electrical cardioversion. 61
28323361 2017
45
A second-degree atrioventricular block with double escape rhythm secondary to paroxysmal vagal hypertonia. 61
28857928 2017
46
Permanent pacemaker implantation in octogenarians with unexplained syncope and positive electrophysiologic testing. 61
28089877 2017
47
Obstetric and perinatal outcome in anti-Ro/SSA-positive pregnant women: a prospective cohort study. 61
28138914 2017
48
Computed tomography is important in appropriately diagnosing patients with third-degree atrioventricular block and second-degree atrioventricular block but not Wenckebach type. 61
27886613 2017
49
Hisian extrasystole mimicking second degree atrioventricular block. a case report. 61
29424877 2017
50
Pyloric obstruction secondary to epicardial pacemaker implantation: a case report. 61
27913077 2017

Variations for Second-Degree Atrioventricular Block

Expression for Second-Degree Atrioventricular Block

Search GEO for disease gene expression data for Second-Degree Atrioventricular Block.

Pathways for Second-Degree Atrioventricular Block

Pathways related to Second-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.2 TNNI3 SCN5A PPP2R5A CACNA1D
2
Show member pathways
11.71 S1PR5 S1PR3 S1PR1 PPP2R5A
3
Show member pathways
11.67 S1PR5 S1PR3 S1PR1
4 11.63 S1PR5 S1PR3 S1PR1 PPP2R5A
5 11.62 S1PR5 S1PR3 S1PR1
6
Show member pathways
11.42 SCN5A SCN3B CACNA1D
7 10.95 SCN5A SCN3B
8 10.75 S1PR5 S1PR3 S1PR1
9 10.67 SCN5A SCN3B HCN4 CACNA1D
10 10.28 S1PR5 S1PR3 S1PR1

GO Terms for Second-Degree Atrioventricular Block

Cellular components related to Second-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.93 TRIM44 TRIM21 TNNI3 TAZ SSB SCN5A
2 voltage-gated sodium channel complex GO:0001518 8.96 SCN5A SCN3B
3 Z disc GO:0030018 8.92 SCN5A SCN3B PPP2R5A CACNA1D

Biological processes related to Second-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 regulation of ion transmembrane transport GO:0034765 9.8 SCN5A SCN3B HCN4 CACNA1D
2 sodium ion transport GO:0006814 9.78 SCN5A SCN3B HCN4
3 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.76 S1PR5 S1PR3 S1PR1 MC3R
4 muscle contraction GO:0006936 9.75 TNNI3 TAZ HCN4
5 sodium ion transmembrane transport GO:0035725 9.74 SCN5A SCN3B HCN4
6 cardiac conduction GO:0061337 9.69 SCN5A SCN3B CACNA1D
7 cardiac muscle contraction GO:0060048 9.67 TNNI3 TAZ SCN5A SCN3B
8 regulation of heart rate GO:0002027 9.65 SCN5A MC3R HCN4
9 regulation of heart rate by cardiac conduction GO:0086091 9.62 SCN5A SCN3B HCN4 CACNA1D
10 membrane depolarization GO:0051899 9.61 SCN5A SCN3B
11 cardiac muscle cell action potential involved in contraction GO:0086002 9.61 SCN5A SCN3B CACNA1D
12 ventricular cardiac muscle cell action potential GO:0086005 9.6 SCN5A SCN3B
13 membrane depolarization during action potential GO:0086010 9.59 SCN5A SCN3B
14 positive regulation of sodium ion transport GO:0010765 9.58 SCN5A SCN3B
15 sphingosine-1-phosphate receptor signaling pathway GO:0003376 9.58 S1PR5 S1PR3 S1PR1
16 atrial cardiac muscle cell action potential GO:0086014 9.56 SCN5A SCN3B
17 regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 9.55 SCN5A SCN3B
18 regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 9.54 SCN5A SCN3B
19 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.52 SCN5A CACNA1D
20 SA node cell action potential GO:0086015 9.43 SCN5A SCN3B HCN4
21 membrane depolarization during SA node cell action potential GO:0086046 9.33 SCN5A HCN4 CACNA1D
22 regulation of metabolic process GO:0019222 9.26 S1PR5 S1PR3 S1PR1 MC3R
23 membrane depolarization during cardiac muscle cell action potential GO:0086012 8.92 SCN5A SCN3B HCN4 CACNA1D

Molecular functions related to Second-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.46 SCN5A SCN3B HCN4 CACNA1D
2 voltage-gated sodium channel activity GO:0005248 9.37 SCN5A HCN4
3 ankyrin binding GO:0030506 9.32 SCN5A CACNA1D
4 voltage-gated sodium channel activity involved in cardiac muscle cell action potential GO:0086006 9.26 SCN5A SCN3B
5 sodium channel activity GO:0005272 9.13 SCN5A SCN3B HCN4
6 sphingosine-1-phosphate receptor activity GO:0038036 8.8 S1PR5 S1PR3 S1PR1

Sources for Second-Degree Atrioventricular Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
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43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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