MCID: SCN049
MIFTS: 26

Second-Degree Atrioventricular Block

Categories: Cardiovascular diseases

Aliases & Classifications for Second-Degree Atrioventricular Block

MalaCards integrated aliases for Second-Degree Atrioventricular Block:

Name: Second-Degree Atrioventricular Block 12 15
Second Degree Atrioventricular Block 73
Second-Degree Heart Block 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050822
ICD10 33 I44.1
UMLS 73 C0264906

Summaries for Second-Degree Atrioventricular Block

MalaCards based summary : Second-Degree Atrioventricular Block, also known as second degree atrioventricular block, is related to atrioventricular block and atrial standstill 1. An important gene associated with Second-Degree Atrioventricular Block is WDR62 (WD Repeat Domain 62), and among its related pathways/superpathways is Antiarrhythmic Pathway, Pharmacodynamics. The drugs rituximab and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and atrioventricular node.

Wikipedia : 76 Second-degree atrioventricular block (AV block) is a disease of the electrical conduction system of the... more...

Related Diseases for Second-Degree Atrioventricular Block

Graphical network of the top 20 diseases related to Second-Degree Atrioventricular Block:



Diseases related to Second-Degree Atrioventricular Block

Symptoms & Phenotypes for Second-Degree Atrioventricular Block

Drugs & Therapeutics for Second-Degree Atrioventricular Block

Drugs for Second-Degree Atrioventricular Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 3 174722-31-7 10201696
2 Immunologic Factors Phase 3
3 Antirheumatic Agents Phase 3
4 Bendamustine Hydrochloride Phase 3
5 Alkylating Agents Phase 3
6 Antineoplastic Agents, Alkylating Phase 3
7
Guaifenesin Approved, Investigational, Vet_approved Phase 2 93-14-1 3516
8
Codeine Approved, Illicit Phase 2 76-57-3 5284371
9
Acetaminophen Approved Phase 2 103-90-2 1983
10
Adenosine Approved, Investigational Phase 2 58-61-7 60961
11 Antitussive Agents Phase 2
12 Respiratory System Agents Phase 2
13 Chlorpheniramine, phenylpropanolamine drug combination Phase 2
14 Narcotics Phase 2,Phase 1
15 Peripheral Nervous System Agents Phase 2,Phase 1
16 Analgesics, Non-Narcotic Phase 2
17 Analgesics Phase 2,Phase 1
18 Central Nervous System Depressants Phase 2,Phase 1
19 Analgesics, Opioid Phase 2,Phase 1
20 Antipyretics Phase 2
21 Neurotransmitter Agents Phase 2
22 Adenosine A1 Receptor Agonists Phase 2
23 Pharmaceutical Solutions Phase 2
24 Estradiol valerate Approved, Investigational, Vet_approved Phase 1 979-32-8
25
Naltrexone Approved, Investigational, Vet_approved Phase 1 16590-41-3 5360515
26
Norgestimate Approved, Investigational Phase 1 35189-28-7 6540478
27
Estradiol Approved, Investigational, Vet_approved Phase 1 50-28-2 5757
28
Polyestradiol phosphate Approved Phase 1 28014-46-2
29
Moxifloxacin Approved, Investigational Phase 1 354812-41-2, 151096-09-2 152946
30
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 1 52485-79-7 40400 644073
31
Ethinyl Estradiol Approved Phase 1 57-63-6 5991
32
Oxymetazoline Approved, Investigational Phase 1 1491-59-4 4636
33
Macitentan Approved Phase 1 441798-33-0
34
Phenylephrine Approved Phase 1 59-42-7 6041
35 Contraceptives, Oral Phase 1
36 Nucleic Acid Synthesis Inhibitors Phase 1
37 Contraceptive Agents Phase 1
38 Narcotic Antagonists Phase 1
39 Norgestimate, ethinyl estradiol drug combination Phase 1
40 Estradiol 17 beta-cypionate Phase 1
41 Estradiol 3-benzoate Phase 1
42 Contraceptives, Oral, Combined Phase 1
43 Anti-Infective Agents Phase 1
44 Fluoroquinolones Phase 1
45 Topoisomerase Inhibitors Phase 1
46 Anti-Bacterial Agents Phase 1
47 Endothelin A Receptor Antagonists Phase 1
48 Endothelin Receptor Antagonists Phase 1
49
Lacosamide Approved 175481-36-4, 860352-01-8 219078
50 Anticonvulsants

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Cardiac Sarcoidosis Response To Steroids Trial Withdrawn NCT01210677 Phase 4 Prednisone
2 Study to Assess the Effect of Treatment With Bendamustine in Combination With Rituximab on QT Interval in Patients With Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL) Completed NCT01073163 Phase 3 Bendamustine;Rituximab
3 SB-705498 Dental Pain Study After Tooth Extraction Completed NCT00281684 Phase 2 SB705498 400 mg;SB705498 1000 mg;Placebo;Co-Codamol
4 Multiple Dose Study in Heart Failure of BAY 1067197 Completed NCT02040233 Phase 2 BAY1067197 (10 mg);BAY1067197;Placebo (10 mg);Placebo
5 Efficacy, Safety and Tolerability of BAF312 Compared to Placebo in Patients With Intracerebral Hemorrhage (ICH). Recruiting NCT03338998 Phase 2 BAF312;Placebo
6 The Effect of Buprenorphine Delivered by Buprenorphine Transdermal System (BTDS) at Doses up to 80 Micrograms/Hour (mcg/hr) and Naltrexone on Electrocardiogram (ECG) Intervals in Healthy Volunteers Completed NCT01999114 Phase 1 Buprenorphine transdermal patch;Naltrexone tablet;Placebos (for TDS and for naltrexone and for moxifloxacin);Moxifloxacin tablet
7 Trial to Evaluate the Effects of OPC-34712 on QT/QTc in Subjects With Schizophrenia or Schizoaffective Disorder Completed NCT01423916 Phase 1 OPC-34712 (4mg);Moxifloxacin;OPC-34712 (12mg);Placebo
8 Study to Assess the Effect of Macitentan on the Electrocardiogram (ECG) in Healthy Male and Female Subjects Completed NCT02050802 Phase 1 Moxifloxacin 400 mg;Macitentan 10 mg;Macitentan 30 mg
9 HV Electrophysiology Study In Transcatheter Aortic Valve Implantation Patients Unknown status NCT02659137
10 Post-Authorization Safety Study to Assess the Safety of Vimpat as add-on Therapy in Patients With Partial-onset Seizures Completed NCT00771927 Lacosamide
11 Zero-fluoroscopic Navigation Versus Conventional Fluoroscopic Navigation for Single-chamber Pacemaker Implantation Recruiting NCT03118440 Not Applicable
12 Zero-fluoroscopic Navigation Versus Conventional Fluoroscopic Navigation for Double-chamber Pacemaker Implantation Recruiting NCT03118427 Not Applicable
13 Bifocal Right Ventricular PAcing in Right Bundle Branch blocK and Heart Failure With Reduced Ejection Fraction. The Study Tests the Superiority of Right Ventricular Bifocal Stimulation Over VVI Implantable Defibrillator in Right Bundle Branch Block and Heart Failure. Recruiting NCT03524001 Not Applicable

Search NIH Clinical Center for Second-Degree Atrioventricular Block

Genetic Tests for Second-Degree Atrioventricular Block

Anatomical Context for Second-Degree Atrioventricular Block

MalaCards organs/tissues related to Second-Degree Atrioventricular Block:

41
Heart, Testes, Atrioventricular Node

Publications for Second-Degree Atrioventricular Block

Articles related to Second-Degree Atrioventricular Block:

(show top 50) (show all 98)
# Title Authors Year
1
Second-degree Atrioventricular Block: Conceptions and Misconceptions. ( 29977560 )
2018
2
Dynamic Electrocardiography is Useful in the Diagnosis of Persistent Atrial Fibrillation Accompanied with Second-Degree Atrioventricular Block. ( 30271091 )
2018
3
Type I Second Degree Atrioventricular Block in a Woman With Remote Repair of a Ventricular Septal Defect. ( 30057230 )
2018
4
Resolution of fetal second-degree atrioventricular block. ( 30497753 )
2018
5
Computed tomography is important in appropriately diagnosing patients with third-degree atrioventricular block and second-degree atrioventricular block but not Wenckebach type. ( 27886613 )
2017
6
Successful prenatal management of ventricular tachycardia and second-degree atrioventricular block in fetal long QT syndrome. ( 28491768 )
2017
7
A second-degree atrioventricular block with double escape rhythm secondary to paroxysmal vagal hypertonia. ( 28857928 )
2017
8
Hisian extrasystole mimicking second degree atrioventricular block. a case report. ( 29424877 )
2017
9
Mobitz type 1 second-degree atrioventricular block by triazolam and brotizolam overdose. ( 29123752 )
2016
10
A case of advanced second-degree atrioventricular block in a ferret secondary to lymphoma. ( 27200273 )
2016
11
Second-Degree Atrioventricular Block Occurring After Tooth Extraction. ( 27585419 )
2016
12
ECG Case of the Month: Unexpected Atrioventricular Conduction in High-Grade Atrioventricular Block. Sinus rhythm; high-grade second degree atrioventricular block with a junctional escape rhythm and three capture complexes, each with right bundle branch block aberration; possible septal myocardial infarct of indeterminate age; ST-T and U wave changes suggesting hypokalemia. ( 25978059 )
2015
13
Second-degree atrioventricular block type II and third-degree atrioventricular block requiring cardiac pacing after tooth extraction. ( 25914824 )
2015
14
Mobitz type II second-degree atrioventricular block during dobutamine stress echocardiography. True or false? ( 25080840 )
2014
15
Syncope secondary to second-degree atrioventricular block with donepezil use. ( 25484499 )
2014
16
Second-degree atrioventricular block. ( 25318341 )
2014
17
Mobitz type II second-degree atrioventricular block with narrow QRS and junctional extrasystoles: what is the mechanism? ( 24237845 )
2014
18
Long-term follow-up of older patients with Mobitz type I second degree atrioventricular block. ( 23086974 )
2013
19
Mobitz type 1 second degree atrioventricular block: the value of permanent pacing in the older patient. ( 23242834 )
2013
20
Exercise-induced second-degree atrioventricular block in endurance athletes. ( 23059863 )
2013
21
Second-degree atrioventricular block revisited. ( 23224264 )
2012
22
Prolonged ventricular pauses in an asymptomatic athlete with "apparent Mobitz type II second-degree atrioventricular block". ( 21261666 )
2012
23
ECG of the Month. Second-degree atrioventricular block in a cat. ( 22852566 )
2012
24
Late occurrence of transient advanced second degree atrioventricular block after successful transcatheter cryoablation of atrioventricular nodal reentry tachycardia. ( 24826272 )
2012
25
Markedly varying PR intervals during second degree atrioventricular block: possible mechanisms. ( 22664821 )
2012
26
Mobitz type II second-degree atrioventricular block in athletes: true or false? ( 18801768 )
2011
27
Lacosamide-induced second-degree atrioventricular block in a patient with partial epilepsy. ( 21801173 )
2011
28
A rare cause of trauma in the elderly: Mobitz type-II second-degree atrioventricular block. ( 22166702 )
2011
29
Type I second-degree atrioventricular block and intermittent left posterior fascicular block in a 26-year-old woman with an inferoposterior acute myocardial infarct. ( 21240299 )
2009
30
Ecg of the month. Arrhythmia on an ambulatory electrocardiogram. Sinus rhythm with second degree atrioventricular block, type I (Wenckebach); non-conducted atrial premature complexes; and concealed conduction of the fourth sinus P wave into atrioventricular junction. ( 19489387 )
2009
31
Second-degree atrioventricular block (Mobitz Type I) in an adolescent with anorexia nervosa: intrinsic or acquired conduction abnormality. ( 19189406 )
2009
32
Second degree atrioventricular block Mobitz type I after administration of benzathine penicillin: case report. ( 19488534 )
2009
33
Persistent second-degree atrioventricular block following adenosine infusion for nuclear stress testing. ( 18301154 )
2008
34
Second-degree atrioventricular block as the first sign of sarcoidosis in a previously asymptomatic patient. ( 17608106 )
2007
35
Identifying second-degree atrioventricular block (type I). ( 18046202 )
2007
36
Second-degree atrioventricular block and the haystack principle. ( 16415651 )
2006
37
Anorexia nervosa and second-degree atrioventricular block (Type I). ( 16937388 )
2006
38
Exercise-induced second-degree atrioventricular block. ( 16083979 )
2006
39
Right bundle branch block and second-degree atrioventricular block: what is the mechanism? ( 15851328 )
2005
40
[Second degree atrioventricular block in mixed connective tissue disease]. ( 15925432 )
2005
41
ECG of the month. Hypotension, pulmonary edema, and an irregular cardiac rhythm in a 50-year-old woman. Sinus tachycardia, type I (Wenckebach) second degree atrioventricular block, acute inferoposterior myocardial infarct, and anterolateral myocardial infarct of indeterminate age (probably old). ( 16374966 )
2005
42
Second-degree atrioventricular block as an early manifestation of adult systemic lupus erythematosus. ( 16118680 )
2005
43
Perinatal outcome of fetus with isolated congenital second degree atrioventricular block without maternal anti-SSA/Ro-SSB/La antibodies. ( 16219517 )
2005
44
Woldemar Mobitz and His 1924 classification of second-degree atrioventricular block. ( 15339865 )
2004
45
ECG of the month. Slow bigeminal rhythm. Low atrial or junctional rhythm, second degree atrioventricular block, right ventricular escape beats, ventricular escape-capture bigeminy, ventriculophasic atrial arrhythmia, and right bundle branch block. ( 15366342 )
2004
46
A case of non-conducted atrial bigeminy simulating a second-degree atrioventricular block. A holter ECG diagnosis. ( 15641178 )
2004
47
Apparent bradycardia-dependent advanced second-degree atrioventricular block. ( 11953916 )
2002
48
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 17-2002. A 55-year-old man with second-degree atrioventricular block and chest pain. ( 12037154 )
2002
49
Second-degree atrioventricular block: a reappraisal. ( 11155413 )
2001
50
The Chicago School of Electrocardiography and second-degree atrioventricular block: an historical perspective. ( 11270692 )
2001

Variations for Second-Degree Atrioventricular Block

Expression for Second-Degree Atrioventricular Block

Search GEO for disease gene expression data for Second-Degree Atrioventricular Block.

Pathways for Second-Degree Atrioventricular Block

Pathways related to Second-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.37 HCN4 LMNA

GO Terms for Second-Degree Atrioventricular Block

Sources for Second-Degree Atrioventricular Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
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62 PubMed
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69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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