MCID: SCN049
MIFTS: 33

Second-Degree Atrioventricular Block

Categories: Cardiovascular diseases

Aliases & Classifications for Second-Degree Atrioventricular Block

MalaCards integrated aliases for Second-Degree Atrioventricular Block:

Name: Second-Degree Atrioventricular Block 12 15
Second Degree Atrioventricular Block 71
Second-Degree Heart Block 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050822
ICD10 32 I44.1
UMLS 71 C0264906

Summaries for Second-Degree Atrioventricular Block

Disease Ontology : 12 An atrioventricular block that is characterized by progressive prolongation of the PR interval on consecutive beats followed by a blocked P wave on electrocardiogram or intermittently non-conducted P waves not preceded by PR changes on electrocardiogram caused by a conduction block between the atria and the ventricles through the atrioventricular node.

MalaCards based summary : Second-Degree Atrioventricular Block, also known as second degree atrioventricular block, is related to atrioventricular block and right bundle branch block. An important gene associated with Second-Degree Atrioventricular Block is TRIM21 (Tripartite Motif Containing 21), and among its related pathways/superpathways are Cardiac conduction and cGMP-PKG signaling pathway. Affiliated tissues include heart, atrioventricular node and kidney, and related phenotype is immune system.

Wikipedia : 74 Second-degree atrioventricular block (AV block) is a disease of the electrical conduction system of the... more...

Related Diseases for Second-Degree Atrioventricular Block

Diseases related to Second-Degree Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 atrioventricular block 31.4 TRIM21 TNNI3 SSB SCN5A HCN4
2 right bundle branch block 30.6 TNNI3 SCN5A SCN3B HCN4
3 first-degree atrioventricular block 30.5 TRIM21 SCN5A
4 cardiac conduction defect 30.4 SCN5A HCN4
5 left bundle branch hemiblock 30.4 TNNI3 SCN5A
6 atrial fibrillation 30.3 SCN5A SCN3B HCN4
7 sick sinus syndrome 30.3 SCN5A SCN3B HCN4
8 cardiac arrhythmia 30.3 SCN5A SCN3B HCN4
9 heart block, congenital 30.1 TRIM21 SSB CACNA1D
10 third-degree atrioventricular block 30.0 TRIM21 SSB SCN5A HCN4 CACNA1D
11 long qt syndrome 29.5 SCN5A SCN3B HCN4 CALM2 CACNA1D
12 progressive familial heart block, type ia 10.7
13 syncope 10.5
14 progressive familial heart block, type ib 10.5
15 inferior myocardial infarction 10.4
16 diffuse infiltrative lymphocytosis syndrome 10.3 TRIM21 SSB
17 mononeuritis of upper limb and mononeuritis multiplex 10.3 TRIM21 SSB
18 mononeuritis multiplex 10.3 TRIM21 SSB
19 parotid disease 10.3 TRIM21 SSB
20 polyclonal hypergammaglobulinemia 10.3 TRIM21 SSB
21 sarcoidosis 1 10.2
22 anorexia nervosa 10.2
23 heart septal defect 10.2
24 hypokalemia 10.2
25 myocarditis 10.2
26 acute myocardial infarction 10.2
27 sickle cell disease 10.2
28 parotitis 10.2 TRIM21 SSB
29 orbital granuloma 10.2 TRIM21 SSB
30 familial sick sinus syndrome 10.2 SCN5A HCN4
31 xerophthalmia 10.2 TRIM21 SSB
32 dyskinesia of esophagus 10.2 TRIM21 SSB
33 raynaud disease 10.2 TRIM21 SSB
34 mononeuropathy 10.2 TRIM21 SSB
35 lateral myocardial infarction 10.2 TNNI3 SCN5A
36 keratoconjunctivitis sicca 10.2 TRIM21 SSB
37 sialadenitis 10.1 TRIM21 SSB
38 atrial standstill 1 10.1
39 creatine phosphokinase, elevated serum 10.1
40 systemic lupus erythematosus 10.1
41 scleroderma, familial progressive 10.1
42 graves disease 1 10.1
43 cyanosis, transient neonatal 10.1
44 aortic valve disease 2 10.1
45 lymphoma 10.1
46 dermatomyositis 10.1
47 mobitz type ii atrioventricular block 10.1
48 pulmonary edema 10.1
49 lyme disease 10.1
50 graves' disease 10.1

Graphical network of the top 20 diseases related to Second-Degree Atrioventricular Block:



Diseases related to Second-Degree Atrioventricular Block

Symptoms & Phenotypes for Second-Degree Atrioventricular Block

MGI Mouse Phenotypes related to Second-Degree Atrioventricular Block:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 IFNB1 MC3R PPP2R5A S1PR1 S1PR3 S1PR5

Drugs & Therapeutics for Second-Degree Atrioventricular Block

Search Clinical Trials , NIH Clinical Center for Second-Degree Atrioventricular Block

Genetic Tests for Second-Degree Atrioventricular Block

Anatomical Context for Second-Degree Atrioventricular Block

MalaCards organs/tissues related to Second-Degree Atrioventricular Block:

40
Heart, Atrioventricular Node, Kidney, Cervix, Pituitary

Publications for Second-Degree Atrioventricular Block

Articles related to Second-Degree Atrioventricular Block:

(show top 50) (show all 506)
# Title Authors PMID Year
1
Second-Degree Atrioventricular Block-Reply. 61
33555309 2021
2
Second-degree Atrioventricular Block. 61
33555298 2021
3
Strange case of biventricular heart failure. 61
33462057 2021
4
Capability of emergency nurses for electrocardiogram interpretation. 61
33360363 2021
5
Lithium-induced symptomatic second-degree heart block: A case report. 61
33264720 2021
6
Mobitz Type II Atrioventricular Heart Block After Candlenut Ingestion. 61
33017016 2020
7
A case report of a rare cardiac complication in novel coronavirus disease. 61
33442589 2020
8
Dengue disease in a pediatric patient with severe idiopathic pulmonary hypertension. 61
33308360 2020
9
Exacerbation of atrioventricular block associated with concomitant use of amlodipine and aprepitant in a lung cancer patient: A case report. 61
33355084 2020
10
Timed RR-interval Scatter Plots and Reverse Technology. 61
33428149 2020
11
Electrocardiographic Findings in Bitches Affected by Closed Cervix Pyometra. 61
33233788 2020
12
Electroanatomic Mapping and Intracardiac Echocardiography-Guided Approach for Left-Bundle Branch Area Pacing With Zero Fluoroscopy. 61
33305233 2020
13
Fetal ventricular tachycardia: betablockers should be the first line treatment. 61
33068771 2020
14
Mechanisms, features, and significance of diastolic mitral regurgitation: a case series. 61
33426438 2020
15
Incomplete Trifascicular Block and Mobitz Type II Atrioventricular Block in COVID-19. 61
33083164 2020
16
Visual representations of canine cardiac arrhythmias with Lorenz (Poincaré) plots. 61
33112172 2020
17
How to differentiate second-degree atrioventricular block from extrasystoles in fetuses with a bigeminal ventricular rhythm. 61
32323298 2020
18
Right and left-sided infective endocarditis in an IV drug abuser. 61
33235687 2020
19
Self-Resolving Mobitz Type II Second-Degree Heart Block (Atypical Wenckebach Block) After Cesarean Section Under Subarachnoid Block: A Case Report. 61
33133869 2020
20
Pseudo atrioventricular block most likely caused by junctional extrasystoles mimicking Mobitz II second degree atrioventricular block: A case report. 61
32817829 2020
21
Transient Second-Degree Atrioventricular Block: A Rare Finding in Sickle Cell Crisis. 61
32782895 2020
22
Cardiac effects of repeated focal seizures in rats induced by intrahippocampal tetanus toxin: Bradyarrhythmias, tachycardias, and prolonged interictal QT interval. 61
32201948 2020
23
Dynamic changes in electrocardiograms of a premature infant with hyperkalemia and hypocalcemia. 61
32023498 2020
24
[Increased Ventricular Pacing Threshold Caused by Intake of Dronedaron]. 61
32069492 2020
25
Second-degree atrioventricular block in an adolescent with an acute alcohol intoxication. 61
31708246 2020
26
Arrhythmias in Patients on Maintenance Dialysis: A Cross-sectional Study. 61
31542235 2020
27
[Second-degree atrioventricular block caused by Lyme disease]. 61
32186826 2020
28
Pembrolizumab-Induced Mobitz Type 2 Second-Degree Atrioventricular Block. 61
32047674 2020
29
Lacosamide-associated second-degree atrioventricular block in a healthy, young athlete. 61
32642638 2020
30
Noninvasive Fetal Electrocardiography in the Diagnosis of Long QT Syndrome: A Case Series. 61
32615554 2020
31
Thrombocytopenia Preceding Urosepsis in an Otherwise Asymptomatic Patient After Bilateral Retrograde Intrarenal Surgery. 61
33457648 2020
32
Heart Block Caused by Cardiac Metastasis From Merkel Cell Carcinoma: A Case Report. 61
31993571 2019
33
Severe Hypoglycemia-Induced Fatal Cardiac Arrhythmias Are Mediated by the Parasympathetic Nervous System in Rats. 61
31439645 2019
34
Analysis of cardiac monitoring and safety data in patients initiating fingolimod treatment in the home or in clinic. 61
31729968 2019
35
Crataegus mexicana (Tejocote) Exposure Associated with Cardiotoxicity and a Falsely Elevated Digoxin Level. 61
31407210 2019
36
Severe transient neonatal long QT syndrome due to maternal paroxetine usage: a case report. 61
31475669 2019
37
[Exploration of Mahuang Fuzi Xixin Decoction formula syndromes based on severe cases of critical care and its application for nosocomial infection in critical care medicine including hyperpyrexia after tracheotomy and severe pain accompanied by acute myocardial infarction and diabetic peripheral neuropathy]. 61
31872717 2019
38
Establishing 24-hour Holter reference intervals for clinically healthy puppies. 61
31325639 2019
39
Second degree heart block following the administration of dexmedetomidine. 61
30622043 2019
40
Frequency and characteristics of exercise-induced second-degree atrioventricular block in patients undergoing stress testing. 61
30925274 2019
41
Case report: Atrioventricular block after transcatheter atrial septal closure using the Figulla® Flex II ASD occluder. 61
30773790 2019
42
Cardiac Arrhythmias in Horses. 61
30871832 2019
43
[Abnormal ECG findings in athletes]. 61
30920551 2019
44
The influence of anesthesia with isoflurane on the pulmonary and aortic blood flow of Racing Pigeons (Columba livia f. domestica) measured by pulsed wave Doppler echocardiography. 61
31086761 2019
45
Lyme carditis presenting as atrial fibrillation. 61
31036741 2019
46
Advanced Heart Block in Children with Lyme Disease. 61
30377753 2019
47
Evaluation of heart rate variability and behavior of electrocardiographic parameters in dogs affected by chronic Monocytic Ehrlichiosis. 61
31125348 2019
48
Severe Cardiorespiratory and Neurologic Symptoms in a Neonate due to Mepivacaine Intoxication. 61
31428498 2019
49
Implantable loop recorders in patients with unexplained syncope: Clinical predictors of pacemaker implantation. 61
29399750 2019
50
Aripiprazole Overdose and Transient 2:1 Second Degree Atrioventricular Block: Only A Coincidence? 61
30659549 2019

Variations for Second-Degree Atrioventricular Block

Expression for Second-Degree Atrioventricular Block

Search GEO for disease gene expression data for Second-Degree Atrioventricular Block.

Pathways for Second-Degree Atrioventricular Block

Pathways related to Second-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.58 TNNI3 SCN5A SCN3B CALM2 CACNA1D
2
Show member pathways
12.27 TNNI3 SCN5A PPP2R5A CALM2 CACNA1D
3 12.07 TNNI3 HCN4 CALM2 CACNA1D
4
Show member pathways
11.79 S1PR5 S1PR3 S1PR1 PPP2R5A
5
Show member pathways
11.71 S1PR5 S1PR3 S1PR1
6 11.7 S1PR5 S1PR3 S1PR1 PPP2R5A
7 11.65 S1PR5 S1PR3 S1PR1
8
Show member pathways
11.33 SCN5A SCN3B CALM2 CACNA1D
9 10.99 SCN5A SCN3B
10 10.85 S1PR5 S1PR3 S1PR1
11 10.67 SCN5A SCN3B HCN4 CACNA1D
12 10.28 S1PR5 S1PR3 S1PR1

GO Terms for Second-Degree Atrioventricular Block

Cellular components related to Second-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated sodium channel complex GO:0001518 8.96 SCN5A SCN3B
2 Z disc GO:0030018 8.92 SCN5A SCN3B PPP2R5A CACNA1D

Biological processes related to Second-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 regulation of ion transmembrane transport GO:0034765 9.78 SCN5A SCN3B HCN4 CACNA1D
2 sodium ion transport GO:0006814 9.77 SCN5A SCN3B HCN4
3 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.76 S1PR5 S1PR3 S1PR1 MC3R
4 sodium ion transmembrane transport GO:0035725 9.74 SCN5A SCN3B HCN4
5 cardiac conduction GO:0061337 9.69 SCN5A SCN3B CACNA1D
6 cardiac muscle contraction GO:0060048 9.67 TNNI3 SCN5A SCN3B
7 regulation of heart rate by cardiac conduction GO:0086091 9.67 SCN5A SCN3B HCN4 CACNA1D
8 positive regulation of protein dephosphorylation GO:0035307 9.62 PPP2R5A CALM2
9 regulation of heart rate GO:0002027 9.62 SCN5A MC3R HCN4 CALM2
10 regulation of cardiac muscle contraction GO:0055117 9.61 HCN4 CALM2
11 membrane depolarization GO:0051899 9.61 SCN5A SCN3B
12 cardiac muscle cell action potential involved in contraction GO:0086002 9.61 SCN5A SCN3B CACNA1D
13 ventricular cardiac muscle cell action potential GO:0086005 9.59 SCN5A SCN3B
14 membrane depolarization during action potential GO:0086010 9.58 SCN5A SCN3B
15 positive regulation of sodium ion transport GO:0010765 9.58 SCN5A SCN3B
16 sphingosine-1-phosphate receptor signaling pathway GO:0003376 9.58 S1PR5 S1PR3 S1PR1
17 atrial cardiac muscle cell action potential GO:0086014 9.56 SCN5A SCN3B
18 regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 9.55 SCN5A SCN3B
19 regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 9.54 SCN5A SCN3B
20 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.52 SCN5A CACNA1D
21 membrane depolarization during SA node cell action potential GO:0086046 9.43 SCN5A HCN4 CACNA1D
22 SA node cell action potential GO:0086015 9.33 SCN5A SCN3B HCN4
23 regulation of metabolic process GO:0019222 9.26 S1PR5 S1PR3 S1PR1 MC3R
24 membrane depolarization during cardiac muscle cell action potential GO:0086012 8.92 SCN5A SCN3B HCN4 CACNA1D

Molecular functions related to Second-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.78 TRIM21 TNNI3 SCN5A CALM2
2 ion channel activity GO:0005216 9.67 SCN5A HCN4 CACNA1D
3 ion channel binding GO:0044325 9.58 SCN5A SCN3B CALM2
4 voltage-gated sodium channel activity GO:0005248 9.46 SCN5A HCN4
5 voltage-gated ion channel activity GO:0005244 9.46 SCN5A SCN3B HCN4 CACNA1D
6 ankyrin binding GO:0030506 9.43 SCN5A CACNA1D
7 calcium channel inhibitor activity GO:0019855 9.37 TNNI3 CALM2
8 protein phosphatase activator activity GO:0072542 9.32 PPP2R5A CALM2
9 voltage-gated sodium channel activity involved in cardiac muscle cell action potential GO:0086006 9.26 SCN5A SCN3B
10 sodium channel activity GO:0005272 9.13 SCN5A SCN3B HCN4
11 sphingosine-1-phosphate receptor activity GO:0038036 8.8 S1PR5 S1PR3 S1PR1

Sources for Second-Degree Atrioventricular Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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