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MCID: SCN052
MIFTS: 42

Secondary Adrenal Insufficiency

Categories: Rare diseases, Endocrine diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Secondary Adrenal Insufficiency

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MalaCards integrated aliases for Secondary Adrenal Insufficiency:

Name: Secondary Adrenal Insufficiency 53 73
Hypocortisolism Secondary to Another Disorder 73

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)


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Summaries for Secondary Adrenal Insufficiency

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NIH Rare Diseases : 53 Adrenal insufficiency is an endocrine disorder that occurs when the adrenal glands do not produce enough of certain hormones. Secondary adrenal insufficiency occurs when the pituitary gland (a pea-sized gland at the base of the brain) fails to produce enough adrenocorticotropin (ACTH), a hormone that stimulates the adrenal glands to produce the hormone cortisol. The lack of these hormones in the body can be caused by reduction or cessation of corticosteroid medication, the surgical removal of pituitary tumors, or changes in the pituitary gland. Symptoms of secondary adrenal insufficiency may include severe fatigue, loss of appetite, weight loss, nausea, vomiting, diarrhea, muscle weakness, irritability, and depression. Treatment includes replacing the hormones that the adrenal glands are not making. The dose of each medication is adjusted to meet the needs of each affected individual.

MalaCards based summary : Secondary Adrenal Insufficiency, also known as hypocortisolism secondary to another disorder, is related to turner syndrome and hypopituitarism. An important gene associated with Secondary Adrenal Insufficiency is AVP (Arginine Vasopressin), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Etomidate and Remifentanil have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and adrenal gland, and related phenotype is renal/urinary system.

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Related Diseases for Secondary Adrenal Insufficiency

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Diseases in the Acute Adrenal Insufficiency family:

Secondary Adrenal Insufficiency

Diseases related to Secondary Adrenal Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 turner syndrome 29.5 IGF1 IGFBP3
2 hypopituitarism 28.3 IGF1 IGFBP3 INS
3 insulin-like growth factor i 28.3 IGF1 IGFBP3 INS
4 hypoadrenocorticism, familial 11.0
5 central nervous system organ benign neoplasm 10.3 AVP IGF1
6 pituitary hormone deficiency, combined, 2 10.3 AVP IGF1
7 slipped capital femoral epiphysis 10.1 IGF1 IGFBP3
8 pituitary adenoma 1, multiple types 10.1 IGF1 IGFBP3
9 diffuse idiopathic skeletal hyperostosis 10.1 IGF1 IGFBP3
10 central precocious puberty 10.1 IGF1 IGFBP3
11 mammographic density 10.1 IGF1 IGFBP3
12 isolated growth hormone deficiency, type ib 10.1 IGF1 IGFBP3
13 acid-labile subunit deficiency 10.1 IGF1 IGFBP3
14 laron syndrome 10.1 IGF1 IGFBP3
15 growth hormone deficiency 10.1 IGF1 IGFBP3
16 osteogenesis imperfecta, type i 10.0 IGF1 IGFBP3
17 exudative vitreoretinopathy 1 10.0 IGF1 IGFBP3
18 colorectal adenoma 10.0 IGF1 IGFBP3
19 male reproductive organ cancer 10.0 IGF1 IGFBP3
20 breast disease 9.9 IGF1 IGFBP3
21 chromophobe adenoma 9.9 AVP INS
22 sheehan syndrome 9.9 IGF1 INS
23 silver-russell syndrome 9.9 IGF1 IGFBP3
24 diabetes insipidus 9.9 AVP INS
25 donohue syndrome 9.9 IGF1 INS
26 rubeosis iridis 9.8 IGF1 INS
27 endocrine pancreas disease 9.8 IGF1 INS
28 adrenal gland hyperfunction 9.8
29 spinal cord injury 9.8
30 anovulation 9.8 IGF1 INS
31 thyroid gland disease 9.8 IGF1 INS
32 gonadal disease 9.8 IGF1 INS
33 acanthosis nigricans 9.8 IGF1 INS
34 retinal vascular disease 9.8 IGF1 INS
35 cell type benign neoplasm 9.8 IGF1 INS
36 craniopharyngioma 9.8 IGF1 INS
37 hyperandrogenism 9.8 IGF1 INS
38 sleep apnea 9.7 IGF1 INS
39 urinary system disease 9.7 AVP INS
40 microvascular complications of diabetes 5 9.7 IGF1 INS
41 hypothyroidism 9.7
42 mood disorder 9.7
43 pituitary adenoma 9.7
44 pituitary carcinoma 9.7
45 adenoma 9.7
46 hyperthyroidism 9.7
47 renal cell carcinoma, nonpapillary 9.7
48 stiff-person syndrome 9.7
49 malakoplakia 9.7
50 pituitary tumors 9.7

Graphical network of the top 20 diseases related to Secondary Adrenal Insufficiency:



Diseases related to Secondary Adrenal Insufficiency
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Symptoms & Phenotypes for Secondary Adrenal Insufficiency

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MGI Mouse Phenotypes related to Secondary Adrenal Insufficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 AVP IGF1 IGFBP3 INS
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Drugs & Therapeutics for Secondary Adrenal Insufficiency

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Drugs for Secondary Adrenal Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 147)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etomidate Approved Phase 4,Not Applicable 33125-97-2 36339 667484
2
Remifentanil Approved Phase 4 132875-61-7 60815
3
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 50-23-7 5754
4
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
5
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
6
Cisatracurium Approved Phase 4 96946-41-7
7
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
8
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 51-43-4 5816
9
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
10
Racepinephrine Approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 329-65-7 838
11
Menthol Approved Phase 4,Early Phase 1 2216-51-5 16666
12
Budesonide Approved Phase 4 51333-22-3 63006 5281004
13
Cortisone acetate Approved, Investigational Phase 4 1950-04-4, 50-04-4 5745
14
Clobetasol Approved, Investigational Phase 4,Phase 2 25122-46-7, 25122-41-2 32798 5311051
15
Desoximetasone Approved Phase 4,Phase 2 382-67-2 5311067
16
Fluticasone Approved, Experimental, Investigational Phase 4,Phase 3 90566-53-3 62924
17
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
18
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
19
Butyric Acid Experimental, Investigational Phase 4,Not Applicable,Early Phase 1 107-92-6 264
20 Analgesics Phase 4
21 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
22 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
23 Central Nervous System Depressants Phase 4,Not Applicable
24 Adjuvants, Anesthesia Phase 4,Not Applicable
25 Cholinergic Agents Phase 4
26 Cholinergic Antagonists Phase 4
27 Narcotics Phase 4
28 Neuromuscular Agents Phase 4
29 Neuromuscular Blocking Agents Phase 4
30 Neuromuscular Nondepolarizing Agents Phase 4
31 Cortisol succinate Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
32 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable,Early Phase 1
33 Analgesics, Opioid Phase 4
34 Anesthetics Phase 4,Not Applicable
35 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
36 Anesthetics, General Phase 4,Not Applicable
37 Anesthetics, Intravenous Phase 4,Not Applicable
38 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
39 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
40 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
41 Hydrocortisone 17-butyrate 21-propionate Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
42 Hydrocortisone acetate Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
43 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
44 Epinephryl borate Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
45 Hypnotics and Sedatives Phase 4,Not Applicable
46 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
47
Cortisone Phase 4 53-06-5 222786
48
Salmeterol xinafoate Phase 4 94749-08-3 56801
49 Fluticasone Propionate, Salmeterol Xinafoate Drug Combination Phase 4
50 Adrenergic Agents Phase 4,Phase 3,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 57)
# Name Status NCT ID Phase Drugs
1 THe Comparison of Target Controlled Infusion of Propofol or Etomidate at General Anesthesia in Geriatric Patients Unknown status NCT02111265 Phase 4 Remifentanil;Cisatracurium;Sufentanil
2 Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM) Completed NCT02277587 Phase 4 Plenadren;Conventional glucocorticoid therapy
3 Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT) Completed NCT01546922 Phase 4 Hydrocortisone
4 Clinical Trial of Fluticasone Versus Placebo at the Onset of a Cold for Children With Asthma Completed NCT00238927 Phase 4 inhaled fluticasone 750 mcg/day twice daily until 2 days without symptoms (maximum 15 consecutive days)
5 Effect on Adrenal Function of Budesonide Versus Fluticasone in Chronic Obstructive Pulmonary Disease (COPD) Completed NCT01186653 Phase 4 budesonide / formoterol;fluticasone/salmeterol
6 Cutivate Lotion HPA Axis Pediatric Study Completed NCT00546000 Phase 4 Fluticasone propionate 0.05% lotion
7 Comparative Study of Lung Bioavailability of HFA-Seretide Via Current Spacer Devices in Healthy Volunteers Completed NCT01194700 Phase 4 Seretide 250(8puffs) via Evohaler actuator;Seretide 250 (8 puffs)/placebo via Volumatic spacer;Seretide 250/placebo 8 puffs via Aerochamber Plus spacer;Seretide 250/placebo via Synchro-Breathe
8 Evaluation of Adrenal Suppression Potential and Pharmacokinetics of Halobetasol Lotion 0.05% Recruiting NCT03212963 Phase 4 Halobetasol Topical Lotion
9 Adrenal Suppression and Pharmacokinetics of Topicort® Spray, 0.25% in Pediatric Patients With Plaque Psoriasis Recruiting NCT02340169 Phase 4 Topicort® (desoximetasone) Topical Spray, 0.25%
10 Dose of Corticosteroids in COPD Recruiting NCT01742338 Phase 4 Low Dose Corticosteroids;High Dose Corticosteroids
11 Optimising Steroid Replacement in Patients With Adrenal Insufficiency Enrolling by invitation NCT03282487 Phase 4 Modified release hydrocortisone
12 COrticosteroid in Congenital Adrenal Hyperplasia Unknown status NCT02552251 Phase 2, Phase 3
13 Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency Completed NCT00575341 Phase 3 Dehydroepiandrosterone;placebo
14 Epoetin Alfa With or Without Dexamethasone in Treating Fatigue and Anemia in Patients With Hormone-Refractory Prostate Cancer Completed NCT00060398 Phase 3 dexamethasone
15 Comparative Study of Fluticasone Furoate(FF)/Umeclidinium Bromide (UMEC)/ Vilanterol (VI) Closed Therapy Versus FF/VI Plus UMEC Open Therapy in Subjects With Chronic Obstructive Pulmonary Disease (COPD) Completed NCT02729051 Phase 3 FF/UMEC/VI;FF/VI;UMEC;Placebo;Albuterol/salbutamol
16 DFD01 Spray HPA Axis Suppression Study in Adolescent Patients With Moderate to Severe Plaque Psoriasis Recruiting NCT02527421 Phase 3 DFD01 Spray
17 Finding the Optimum Regimen for Duchenne Muscular Dystrophy Active, not recruiting NCT01603407 Phase 3 Prednisone;Prednisone;Deflazacort
18 Inhaled Extra-fine Hydrofluoalkane-beclomethasone (QVAR) in Premature Infants With Bronchopulmonary Dysplasia (BPD) Unknown status NCT01373008 Phase 2 Inhaled extra-fine hydrofluoalkane-beclomethasone (QVAR)
19 Safety Study Evaluating the Adrenal Suppression Potential of Product 0405 in Pediatric Subjects With Atopic Dermatitis Completed NCT01232543 Phase 2 Product 0405
20 Study to Assess the Potential for Adrenal Suppression Following Treatment With DSXS in Patients With Plaque Psoriasis Completed NCT02601469 Phase 2 DSXS
21 An Open Label, Safety Study to Assess the Potential for Adrenal Suppression. Completed NCT02932891 Phase 2 DSXS topical
22 An Open Label, Safety Study to Assess the Potential for Adrenal Suppression Completed NCT02932878 Phase 2 DSXS topical
23 Safety Study to Assess the Potential for Adrenal Suppression Following Maximal Use Treatment With DSXS Completed NCT02933528 Phase 2 DSXS Topical product
24 Pharmacokinetics of 122-0551 and Its Effects on Adrenal Suppression Completed NCT01698333 Phase 2 122-0551
25 Study to Assess the Potential for Adrenal Suppression Following Treatment With DSXS in Patients With Atopic Dermatitis Completed NCT02595008 Phase 2 DSXS
26 HPA Axis Study in Japanese Adults Completed NCT01407510 Phase 2 Mapracorat
27 HPA Axis Study in Adults Completed NCT01408511 Phase 2 Mapracorat
28 An Evaluation of the Adrenal Suppression Potential and Pharmacokinetic Properties of CB-03-01 Cream in Subjects With Acne Vulgaris Completed NCT01831960 Phase 2 cortexolone 17α-propionate
29 Safety Study in Patients With Scalp Psoriasis Suppression Following Maximal Use Treatment With Topical Product Completed NCT02933502 Phase 2 DSXS topical product
30 Desoximetasone Spray 0.25%, Hypothalamic Pituitary Adrenal (HPA) Axis Study Completed NCT01043393 Phase 2 Desoximetasone 0.25% spray
31 DFD06 Cream vs Clobetasol Propionate Cream, 0.05% Hypothalamic- Pituitary-Adrenal (HPA) Axis Suppression Study in Patients With Moderate to Severe Plaque Psoriasis Completed NCT02131324 Phase 2 DFD06 Cream;Clobetasol Propionate Cream 0.05%
32 Dexamethasone to Treat Oral Lichen Planus Completed NCT00111072 Phase 2 dexamethasone 0.01% solution
33 Blinded Study of Topical Investigational Lotion Vs. Approved Cream in Treatment of Plaque Psoriasis Completed NCT01166646 Phase 2 Halobetasol Proprionate Lotion 0.05%;Halobetasol Proprionate Cream 0.05%
34 Effect of LEO 90100 on the HPA Axis and Calcium Metabolism in Subjects With Extensive Psoriasis VulgarisExtensive Psoriasis Vulgaris Completed NCT01600222 Phase 2 LEO 90100
35 Once-A-Month Steroid Treatment for Patients With Focal Segmental Glomerulosclerosis Completed NCT00004990 Phase 2 Dexamethasone
36 An Evaluation of the Adrenal Suppression Potential and PK of CB-03-01 Cream in Pediatric Patients With Acne Vulgaris Recruiting NCT02720627 Phase 2 cortexolone 17α-propionate
37 Assess the Potential for Adrenal Suppression and Systemic Drug Absorption Following Multiple Dosing With DFD-06 Recruiting NCT03179605 Phase 2 DFD06
38 Multiple-Dose Pharmacokinetics and Potential for Adrenal Suppression Following Treatment With Halobetasol Spray in Patients With Atopic Dermatitis Suspended NCT03245385 Phase 2 Treatment with Halobetasol propionate 0.05% topical spray
39 NeSST2: The Development of a Noninvasive Short Synacthen Test Suspended NCT03514589 Phase 2 nasal Tetracosactide;IV tetracosactide
40 Multiple-Dose Pharmacokinetics and Potential for Adrenal Suppression Following Treatment With Halobetasol Spray in Patients With Plaque Psoriasis Withdrawn NCT03298581 Phase 2 Halobetasol Propionate
41 Drug Interaction Study Between Inhaled Beclomethasone and Protease Inhibitors in Healthy Volunteers Completed NCT00936793 Phase 1 Darunavir;Ritonavir;Beclomethasone Dipropionate HFA
42 Metabolic and Endocrine Effects of Repeated Epidural and Sacroiliac Joint Corticosteroid Injections Unknown status NCT01717430
43 Prevalence Study of Adrenal Suppression After Corticosteroids During Chemotherapy Completed NCT01209507
44 Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi Syndrome Completed NCT02368379 Not Applicable
45 Adrenal Suppression and Adrenal Recovery Induced by Megestrol Acetate Completed NCT00575029 Not Applicable megestrol acetate
46 Intra-articular Betamethasone and the Hypothalamic-pituitary-adrenal Axis Completed NCT01799408
47 Does Intravitreal Injection of Triamcinolone Acetonide Impairs the Adrenal Function Completed NCT00561236
48 Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis Completed NCT00552487 Not Applicable synacthen
49 The Risk of Adrenal Insufficiency and Cushing Syndrome Associated With Glucocorticoid Therapy in People With Chronic Inflammatory Diseases Completed NCT03575247 Glucocorticoids
50 The Prevalence of Secondary Adrenal Insufficiency in Patients With Exacerbation of COPD in Glucocorticoid Treatment Related to Differenct Gene Polymorphisms of the Glucocorticoid Receptor Gene Recruiting NCT03140761

Search NIH Clinical Center for Secondary Adrenal Insufficiency

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Genetic Tests for Secondary Adrenal Insufficiency

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Anatomical Context for Secondary Adrenal Insufficiency

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MalaCards organs/tissues related to Secondary Adrenal Insufficiency:

41
Pituitary, Brain, Adrenal Gland, Testes, Lung, Thyroid, Prostate
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Publications for Secondary Adrenal Insufficiency

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Articles related to Secondary Adrenal Insufficiency:

(show top 50) (show all 58)
# Title Authors Year
1
Secondary adrenal insufficiency in pregnancy: any differences? ( 29546743 )
2018
2
Evaluation of the frequency of adrenal crises and preventive measures in patients with primary and secondary adrenal insufficiency in Switzerland. ( 29376554 )
2018
3
Characterization of Cortisol Secretion Rate in Secondary Adrenal Insufficiency. ( 29264545 )
2017
4
Secondary adrenal insufficiency: from the physiopathology to the possible role of modified-release hydrocortisone treatment. ( 28750490 )
2017
5
Primary Hypothyroid and Secondary Adrenal Insufficiency-Searching the Missing Link. ( 28571201 )
2017
6
Secondary Adrenal Insufficiency Due to the Co-Administration of Ritonavir and Inhaled Fluticasone Propionate: Case report. ( 29062559 )
2017
7
GroupA 1. Epidemiology of primary and secondary adrenal insufficiency: Prevalence and incidence, acute adrenal insufficiency, long-term morbidity and mortality. ( 29174931 )
2017
8
Gastric cancer with pituitary metastasis presenting as symptomatic secondary adrenal insufficiency: A case report. ( 28421712 )
2017
9
A case of stiff-person syndrome due to secondary adrenal insufficiency. ( 28552871 )
2017
10
Two cases of late-onset secondary adrenal insufficiency after discontinuation of nivolumab. ( 28945828 )
2017
11
A Case of Psychosis in a Patient with Secondary Adrenal Insufficiency: A Possible Etiological Role of a Hypocortisolemic-induced Increase in Proinflammatory Cytokines. ( 29344425 )
2017
12
National German Audit of Diagnosis, Treatment, and Teaching in Secondary Adrenal Insufficiency. ( 28351092 )
2017
13
Somatosensory function in patients with secondary adrenal insufficiency treated with two different doses of hydrocortisone-Results from a randomized controlled trial. ( 28686664 )
2017
14
Secondary Adrenal Insufficiency Following Nivolumab Therapy in a Patient with Metastatic Renal Cell Carcinoma. ( 28871578 )
2017
15
"Petrified Ears" in Secondary Adrenal Insufficiency. ( 27042511 )
2016
16
Mifepristone Accelerates HPA Axis Recovery in Secondary Adrenal Insufficiency. ( 27516913 )
2016
17
Recovery of adrenal function after chronic secondary adrenal insufficiency in patients with hypopituitarism. ( 26928716 )
2016
18
Large-Dose Glucocorticoid Induced Secondary Adrenal Insufficiency in Spinal Cord Injury. ( 28119833 )
2016
19
Esophageal eosinophilia in secondary adrenal insufficiency. ( 27186162 )
2016
20
Secondary Adrenal Insufficiency: Where Is It Hidden and What Does It Look Like? ( 27211575 )
2016
21
Recovery of Adrenal Function in Patients with Glucocorticoids Induced Secondary Adrenal Insufficiency. ( 26676337 )
2016
22
Reversible Cardiomyopathy Accompanied by Secondary Adrenal Insufficiency. ( 26920218 )
2016
23
Pituitary Antibodies in an Adolescent with Secondary Adrenal Insufficiency and Turner Syndrome. ( 27355580 )
2016
24
Modified-release hydrocortisone decreases BMI and HbA1c in patients with primary and secondary adrenal insufficiency. ( 25656494 )
2015
25
Concomitant giant cell arteritis and secondary adrenal insufficiency. ( 26169623 )
2015
26
Takotsubo cardiomyopathy in a patient with pituitary adenoma and secondary adrenal insufficiency. ( 26816449 )
2015
27
Hyponatremia due to Secondary Adrenal Insufficiency Successfully Treated by Dexamethasone with Sodium Chloride. ( 26319655 )
2015
28
Opioid-induced secondary adrenal insufficiency presenting as hypercalcaemia. ( 26161260 )
2015
29
A Case of Primary and Secondary Adrenal Insufficiency in Children. ( 26092585 )
2015
30
Phosphoglucomutase-1 deficiency: Intrafamilial clinical variability and common secondary adrenal insufficiency. ( 26768186 )
2015
31
Secondary adrenal insufficiency: an overlooked cause of hyponatremia. ( 25699130 )
2015
32
Acute psychosis in the course of treatment of acute adrenal crisis with hydrocortisone in the patient with secondary adrenal insufficiency - a case study. ( 26488344 )
2015
33
Primary vs secondary adrenal insufficiency: ACTH-stimulated aldosterone diagnostic cut-off values by tandem mass spectrometry. ( 25620457 )
2015
34
The effects of two different doses of hydrocortisone on cognition in patients with secondary adrenal insufficiency--results from a randomized controlled trial. ( 25705800 )
2015
35
Inhaled corticosteroids and secondary adrenal insufficiency. ( 25674179 )
2014
36
Acute secondary adrenal insufficiency as the presenting manifestation of small-cell lung carcinoma. ( 24532238 )
2014
37
Iatrogenic Cushing syndrome and secondary adrenal insufficiency related to concomitant triamcinolone and ritonavir administration: a case report and review. ( 25513635 )
2014
38
Iatrogenic Cushing syndrome and secondary adrenal insufficiency related to concomitant triamcinolone and ritonavir administration: a case report and review. ( 23778239 )
2014
39
Health-related quality of life in primary and secondary adrenal insufficiency. ( 25252879 )
2014
40
Flexion contractures of the legs as the manifestation of secondary adrenal insufficiency due to Sheehan's syndrome. ( 22996815 )
2014
41
Secondary adrenal insufficiency after glucocorticosteroid administration in acute spinal cord injury: a case report. ( 24969098 )
2014
42
Severe hyponatremia caused by secondary adrenal insufficiency in a patient with giant pituitary prolactinoma. ( 28509288 )
2013
43
Chemotherapy-induced regression of an adrenocorticotropin-secreting pituitary carcinoma accompanied by secondary adrenal insufficiency. ( 24455332 )
2013
44
Topical corticosteroids and secondary adrenal insufficiency: a relationship in the shade. ( 24076040 )
2013
45
Effects of standard glucocorticoid replacement therapies on subjective well-being: a randomized, double-blind, crossover study in patients with secondary adrenal insufficiency. ( 22930487 )
2012
46
Assessment of glucocorticoid therapy with salivary cortisol in secondary adrenal insufficiency. ( 23034783 )
2012
47
Autoimmune hyperthyroidism due to secondary adrenal insufficiency: resolution with glucocorticoids. ( 20841313 )
2011
48
Malakoplakia of the kidney extending to the descending colon in a patient with secondary adrenal insufficiency: a case report. ( 22745875 )
2011
49
Flexion contractures in secondary adrenal insufficiency. ( 19795178 )
2010
50
Triamcinolone acetonide induced secondary adrenal insufficiency related to impaired CYP3A4 metabolism by coadministration of nefazodone. ( 20456080 )
2010
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Variations for Secondary Adrenal Insufficiency

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Expression for Secondary Adrenal Insufficiency

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Search GEO for disease gene expression data for Secondary Adrenal Insufficiency.
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Pathways for Secondary Adrenal Insufficiency

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Pathways related to Secondary Adrenal Insufficiency according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Regulation of lipid metabolism Insulin signaling-generic cascades 22
Show member pathways
 12.35 IGF1 IGFBP3 INS
2
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.62 IGF1 INS
3
Adipogenesis 1
11.6 IGF1 INS
4
Development IGF-1 receptor signaling 22
Show member pathways
 11.56 IGF1 IGFBP3
5
HIF-1 signaling pathway 37
11.43 IGF1 INS
6
Cardiac Progenitor Differentiation 1
11.09 IGF1 INS
7
Ovarian steroidogenesis 37
11.01 IGF1 INS
8
Differentiation Pathway 1
10.94 IGF1 INS
9
Senescence and Autophagy in Cancer 1
10.82 IGF1 IGFBP3 INS
10
Aldosterone-regulated sodium reabsorption 37
10.72 IGF1 INS
11
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 66
10.28 IGF1 IGFBP3
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GO Terms for Secondary Adrenal Insufficiency

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Cellular components related to Secondary Adrenal Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 AVP IGF1 IGFBP3 INS
2 extracellular region GO:0005576 9.55 AVP IGF1 IGFBP3 INS PGM1
3 insulin-like growth factor ternary complex GO:0042567 8.96 IGF1 IGFBP3
4 insulin-like growth factor binding protein complex GO:0016942 8.62 IGF1 IGFBP3

Biological processes related to Secondary Adrenal Insufficiency according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.78 AVP IGF1 INS
2 positive regulation of cell proliferation GO:0008284 9.77 AVP IGF1 INS
3 regulation of signaling receptor activity GO:0010469 9.71 AVP IGF1 INS
4 positive regulation of gene expression GO:0010628 9.7 AVP IGF1 INS
5 activation of MAPK activity GO:0000187 9.63 IGF1 INS
6 glucose homeostasis GO:0042593 9.62 IGF1 INS
7 response to organic substance GO:0010033 9.62 IGF1 INS
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.61 IGF1 INS
9 positive regulation of cell growth GO:0030307 9.6 AVP INS
10 response to glucose GO:0009749 9.58 IGF1 INS
11 response to insulin GO:0032868 9.58 IGF1 INS
12 cellular protein metabolic process GO:0044267 9.58 IGF1 IGFBP3 INS
13 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.57 IGF1 INS
14 glucose metabolic process GO:0006006 9.56 INS PGM1
15 response to nutrient levels GO:0031667 9.55 IGF1 INS
16 positive regulation of DNA replication GO:0045740 9.51 IGF1 INS
17 activation of protein kinase B activity GO:0032148 9.49 IGF1 INS
18 positive regulation of glucose import GO:0046326 9.48 IGF1 INS
19 ERK1 and ERK2 cascade GO:0070371 9.46 AVP IGF1
20 positive regulation of mitotic nuclear division GO:0045840 9.43 IGF1 INS
21 positive regulation of glycolytic process GO:0045821 9.37 IGF1 INS
22 negative regulation of release of cytochrome c from mitochondria GO:0090201 9.32 AVP IGF1
23 positive regulation of insulin receptor signaling pathway GO:0046628 9.26 IGF1 INS
24 positive regulation of glycogen biosynthetic process GO:0045725 9.16 IGF1 INS
25 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.96 IGF1 IGFBP3
26 positive regulation of MAPK cascade GO:0043410 8.8 IGF1 IGFBP3 INS

Molecular functions related to Secondary Adrenal Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.26 IGF1 INS
2 insulin-like growth factor receptor binding GO:0005159 9.16 IGF1 INS
3 hormone activity GO:0005179 9.13 AVP IGF1 INS
4 receptor activator activity GO:0030546 8.62 IGF1 INS
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Sources for Secondary Adrenal Insufficiency

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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