MCID: SCN052
MIFTS: 41

Secondary Adrenal Insufficiency

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Secondary Adrenal Insufficiency

MalaCards integrated aliases for Secondary Adrenal Insufficiency:

Name: Secondary Adrenal Insufficiency 53 73
Hypocortisolism Secondary to Another Disorder 73

Classifications:



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Summaries for Secondary Adrenal Insufficiency

NIH Rare Diseases : 53 Adrenal insufficiency is an endocrine disorder that occurs when the adrenal glands do not produce enough of certain hormones. Secondary adrenal insufficiency occurs when the pituitary gland (a pea-sized gland at the base of the brain) fails to produce enough adrenocorticotropin (ACTH), a hormone that stimulates the adrenal glands to produce the hormone cortisol. The lack of these hormones in the body can be caused by reduction or cessation of corticosteroid medication, the surgical removal of pituitary tumors, or changes in the pituitary gland. Symptoms of secondary adrenal insufficiency may include severe fatigue, loss of appetite, weight loss, nausea, vomiting, diarrhea, muscle weakness, irritability, and depression. Treatment includes replacing the hormones that the adrenal glands are not making. The dose of each medication is adjusted to meet the needs of each affected individual.

MalaCards based summary : Secondary Adrenal Insufficiency, also known as hypocortisolism secondary to another disorder, is related to turner syndrome and hypopituitarism. An important gene associated with Secondary Adrenal Insufficiency is AVP (Arginine Vasopressin), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and FoxO signaling pathway. The drugs Cisatracurium and Etomidate have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and adrenal gland, and related phenotype is renal/urinary system.

Related Diseases for Secondary Adrenal Insufficiency

Diseases in the Acute Adrenal Insufficiency family:

Secondary Adrenal Insufficiency

Diseases related to Secondary Adrenal Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 turner syndrome 29.7 IGF1 IGFBP3
2 hypopituitarism 29.5 IGF1 IGFBP3 INS
3 pituitary gland disease 29.4 AVP IGF1 INS
4 insulin-like growth factor i 29.3 IGF1 IGFBP3 INS
5 hypoadrenocorticism, familial 11.2
6 pituitary hormone deficiency, combined, 2 10.1 AVP IGF1
7 slipped capital femoral epiphysis 10.0 IGF1 IGFBP3
8 diffuse idiopathic skeletal hyperostosis 10.0 IGF1 IGFBP3
9 marasmus 10.0 IGF1 IGFBP3
10 hypothyroidism 10.0
11 mammographic density 10.0 IGF1 IGFBP3
12 isolated growth hormone deficiency, type ib 10.0 IGF1 IGFBP3
13 growth hormone deficiency 10.0 IGF1 IGFBP3
14 acid-labile subunit deficiency 10.0 IGF1 IGFBP3
15 pituitary adenoma 1, multiple types 10.0 IGF1 IGFBP3
16 osteoporosis, juvenile 10.0 IGF1 IGFBP3
17 laron syndrome 10.0 IGF1 IGFBP3
18 osteogenesis imperfecta, type i 10.0 IGF1 IGFBP3
19 exudative vitreoretinopathy 1 10.0 IGF1 IGFBP3
20 colorectal adenoma 10.0 IGF1 IGFBP3
21 nutritional deficiency disease 10.0 IGF1 IGFBP3
22 male reproductive organ cancer 10.0 IGF1 IGFBP3
23 male reproductive system disease 10.0 IGF1 IGFBP3
24 chromophobe adenoma 10.0 AVP INS
25 sheehan syndrome 10.0 IGF1 INS
26 diabetes insipidus 10.0 AVP INS
27 donohue syndrome 10.0 IGF1 INS
28 silver-russell syndrome 9.9 IGF1 IGFBP3
29 rubeosis iridis 9.9 IGF1 INS
30 thyrotropin-releasing hormone deficiency 9.9
31 brain injury 9.9
32 spinal cord injury 9.9
33 traumatic brain injury 9.9
34 endocrine pancreas disease 9.9 IGF1 INS
35 endocrine organ benign neoplasm 9.9 IGF1 INS
36 anovulation 9.9 IGF1 INS
37 acanthosis nigricans 9.9 IGF1 INS
38 craniopharyngioma 9.9 IGF1 INS
39 cell type benign neoplasm 9.9 IGF1 INS
40 hyperandrogenism 9.9 IGF1 INS
41 sleep apnea 9.9 IGF1 INS
42 urinary system disease 9.9 AVP INS
43 overnutrition 9.9 IGF1 INS
44 microvascular complications of diabetes 5 9.9 IGF1 INS
45 gonadal disease 9.9 IGF1 INS
46 glucose metabolism disease 9.9 IGF1 INS
47 anorexia nervosa 9.9 IGF1 IGFBP3
48 autosomal dominant polycystic kidney disease 9.9 AVP IGF1
49 acquired metabolic disease 9.9 IGF1 INS
50 glucose intolerance 9.8 IGF1 INS

Graphical network of the top 20 diseases related to Secondary Adrenal Insufficiency:



Diseases related to Secondary Adrenal Insufficiency

Symptoms & Phenotypes for Secondary Adrenal Insufficiency

MGI Mouse Phenotypes related to Secondary Adrenal Insufficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 AVP IGF1 IGFBP3 INS

Drugs & Therapeutics for Secondary Adrenal Insufficiency

Drugs for Secondary Adrenal Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 147)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisatracurium Approved Phase 4 96946-41-7
2
Etomidate Approved Phase 4,Not Applicable 33125-97-2 667484 36339
3
Remifentanil Approved Phase 4 132875-61-7 60815
4
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
5
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
6
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
7
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 50-03-3
8
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 50-23-7 5754
9
Racepinephrine Approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 329-65-7 838
10
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 51-43-4 5816
11
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
12
Cortisone acetate Approved, Investigational Phase 4 1950-04-4, 50-04-4 5745
13
Fluticasone Approved, Experimental Phase 4,Phase 3 90566-53-3 62924
14
Budesonide Approved Phase 4 51333-22-3 63006 5281004
15
Clobetasol Approved, Experimental, Investigational Phase 4,Phase 2 25122-46-7, 25122-41-2 5311051 32798
16
Desoximetasone Approved Phase 4,Phase 2 382-67-2 5311067
17
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
18
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
19
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
20
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
21
Cortisone Experimental Phase 4 53-06-5 222786
22
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
23 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable,Early Phase 1
24 Neuromuscular Blocking Agents Phase 4
25 Anesthetics, Intravenous Phase 4,Not Applicable
26 Narcotics Phase 4
27 Anesthetics Phase 4,Not Applicable
28 Cholinergic Antagonists Phase 4
29 Neuromuscular Nondepolarizing Agents Phase 4
30 Cholinergic Agents Phase 4
31 Central Nervous System Depressants Phase 4,Not Applicable
32 Hypnotics and Sedatives Phase 4,Not Applicable
33 Adjuvants, Anesthesia Phase 4,Not Applicable
34 Anesthetics, General Phase 4,Not Applicable
35 Analgesics, Opioid Phase 4
36 Neuromuscular Agents Phase 4
37 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
38 Analgesics Phase 4
39 Hydrocortisone 17-butyrate 21-propionate Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
40 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
41 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
42 Epinephryl borate Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
43 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
44 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
45 Cortisol succinate Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
47 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
49 Hydrocortisone-17-butyrate Phase 4,Not Applicable,Early Phase 1
50 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 60)
# Name Status NCT ID Phase Drugs
1 THe Comparison of Target Controlled Infusion of Propofol or Etomidate at General Anesthesia in Geriatric Patients Unknown status NCT02111265 Phase 4 Remifentanil;Cisatracurium;Sufentanil
2 Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM) Completed NCT02277587 Phase 4 Plenadren;Conventional glucocorticoid therapy
3 Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT) Completed NCT01546922 Phase 4 Hydrocortisone
4 Clinical Trial of Fluticasone Versus Placebo at the Onset of a Cold for Children With Asthma Completed NCT00238927 Phase 4 inhaled fluticasone 750 mcg/day twice daily until 2 days without symptoms (maximum 15 consecutive days)
5 Effect on Adrenal Function of Budesonide Versus Fluticasone in Chronic Obstructive Pulmonary Disease (COPD) Completed NCT01186653 Phase 4 budesonide / formoterol;fluticasone/salmeterol
6 Cutivate Lotion HPA Axis Pediatric Study Completed NCT00546000 Phase 4 Fluticasone propionate 0.05% lotion
7 Comparative Study of Lung Bioavailability of HFA-Seretide Via Current Spacer Devices in Healthy Volunteers Completed NCT01194700 Phase 4 Seretide 250(8puffs) via Evohaler actuator;Seretide 250 (8 puffs)/placebo via Volumatic spacer;Seretide 250/placebo 8 puffs via Aerochamber Plus spacer;Seretide 250/placebo via Synchro-Breathe
8 Evaluation of Adrenal Suppression Potential and Pharmacokinetics of Halobetasol Lotion 0.05% Recruiting NCT03212963 Phase 4 Halobetasol Topical Lotion
9 Adrenal Suppression and Pharmacokinetics of Topicort® Spray, 0.25% in Pediatric Patients With Plaque Psoriasis Recruiting NCT02340169 Phase 4 Topicort® (desoximetasone) Topical Spray, 0.25%
10 Dose of Corticosteroids in COPD Recruiting NCT01742338 Phase 4 Low Dose Corticosteroids;High Dose Corticosteroids
11 Optimising Steroid Replacement in Patients With Adrenal Insufficiency Enrolling by invitation NCT03282487 Phase 4 Modified release hydrocortisone
12 Comparison of Intramuscular and Intravenous ACTH Stimulation Test in Normal Volunteers Not yet recruiting NCT03752190 Phase 4 Cosyntropin
13 COrticosteroid in Congenital Adrenal Hyperplasia Unknown status NCT02552251 Phase 2, Phase 3
14 Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency Completed NCT00575341 Phase 3 Dehydroepiandrosterone;placebo
15 Epoetin Alfa With or Without Dexamethasone in Treating Fatigue and Anemia in Patients With Hormone-Refractory Prostate Cancer Completed NCT00060398 Phase 3 dexamethasone
16 Comparative Study of Fluticasone Furoate(FF)/Umeclidinium Bromide (UMEC)/ Vilanterol (VI) Closed Therapy Versus FF/VI Plus UMEC Open Therapy in Subjects With Chronic Obstructive Pulmonary Disease (COPD) Completed NCT02729051 Phase 3 FF/UMEC/VI;FF/VI;UMEC;Placebo;Albuterol/salbutamol
17 DFD01 Spray HPA Axis Suppression Study in Adolescent Patients With Moderate to Severe Plaque Psoriasis Recruiting NCT02527421 Phase 3 DFD01 Spray
18 Finding the Optimum Regimen for Duchenne Muscular Dystrophy Active, not recruiting NCT01603407 Phase 3 Prednisone;Prednisone;Deflazacort
19 Inhaled Extra-fine Hydrofluoalkane-beclomethasone (QVAR) in Premature Infants With Bronchopulmonary Dysplasia (BPD) Unknown status NCT01373008 Phase 2 Inhaled extra-fine hydrofluoalkane-beclomethasone (QVAR)
20 Safety Study Evaluating the Adrenal Suppression Potential of Product 0405 in Pediatric Subjects With Atopic Dermatitis Completed NCT01232543 Phase 2 Product 0405
21 Study to Assess the Potential for Adrenal Suppression Following Treatment With DSXS in Patients With Plaque Psoriasis Completed NCT02601469 Phase 2 DSXS
22 An Open Label, Safety Study to Assess the Potential for Adrenal Suppression. Completed NCT02932891 Phase 2 DSXS topical
23 An Open Label, Safety Study to Assess the Potential for Adrenal Suppression Completed NCT02932878 Phase 2 DSXS topical
24 Safety Study to Assess the Potential for Adrenal Suppression Following Maximal Use Treatment With DSXS Completed NCT02933528 Phase 2 DSXS Topical product
25 Pharmacokinetics of 122-0551 and Its Effects on Adrenal Suppression Completed NCT01698333 Phase 2 122-0551
26 Study to Assess the Potential for Adrenal Suppression Following Treatment With DSXS in Patients With Atopic Dermatitis Completed NCT02595008 Phase 2 DSXS
27 HPA Axis Study in Japanese Adults Completed NCT01407510 Phase 2 Mapracorat
28 HPA Axis Study in Adults Completed NCT01408511 Phase 2 Mapracorat
29 An Evaluation of the Adrenal Suppression Potential and Pharmacokinetic Properties of CB-03-01 Cream in Subjects With Acne Vulgaris Completed NCT01831960 Phase 2 cortexolone 17α-propionate
30 Safety Study in Patients With Scalp Psoriasis Suppression Following Maximal Use Treatment With Topical Product Completed NCT02933502 Phase 2 DSXS topical product
31 Desoximetasone Spray 0.25%, Hypothalamic Pituitary Adrenal (HPA) Axis Study Completed NCT01043393 Phase 2 Desoximetasone 0.25% spray
32 DFD06 Cream vs Clobetasol Propionate Cream, 0.05% Hypothalamic- Pituitary-Adrenal (HPA) Axis Suppression Study in Patients With Moderate to Severe Plaque Psoriasis Completed NCT02131324 Phase 2 DFD06 Cream;Clobetasol Propionate Cream 0.05%
33 Dexamethasone to Treat Oral Lichen Planus Completed NCT00111072 Phase 2 dexamethasone 0.01% solution
34 Blinded Study of Topical Investigational Lotion Vs. Approved Cream in Treatment of Plaque Psoriasis Completed NCT01166646 Phase 2 Halobetasol Proprionate Lotion 0.05%;Halobetasol Proprionate Cream 0.05%
35 Effect of LEO 90100 on the HPA Axis and Calcium Metabolism in Subjects With Extensive Psoriasis VulgarisExtensive Psoriasis Vulgaris Completed NCT01600222 Phase 2 LEO 90100
36 Once-A-Month Steroid Treatment for Patients With Focal Segmental Glomerulosclerosis Completed NCT00004990 Phase 2 Dexamethasone
37 An Evaluation of the Adrenal Suppression Potential and PK of CB-03-01 Cream in Pediatric Patients With Acne Vulgaris Recruiting NCT02720627 Phase 2 cortexolone 17α-propionate
38 An Open-Label Study to Assess Safety Recruiting NCT03645499 Phase 2 Topical TA-102 A;Topical TA-102 B;Topical TA-102 C
39 Assess the Potential for Adrenal Suppression and Systemic Drug Absorption Following Multiple Dosing With DFD-06 Recruiting NCT03179605 Phase 2 DFD06
40 NeSST2: The Development of a Noninvasive Short Synacthen Test Suspended NCT03514589 Phase 2 nasal Tetracosactide;IV tetracosactide
41 Multiple-Dose Pharmacokinetics and Potential for Adrenal Suppression Following Treatment With Halobetasol Spray in Patients With Atopic Dermatitis Terminated NCT03245385 Phase 2 Treatment with Halobetasol propionate 0.05% topical spray
42 Multiple-Dose Pharmacokinetics and Potential for Adrenal Suppression Following Treatment With Halobetasol Spray in Patients With Plaque Psoriasis Withdrawn NCT03298581 Phase 2 Halobetasol Propionate
43 Drug Interaction Study Between Inhaled Beclomethasone and Protease Inhibitors in Healthy Volunteers Completed NCT00936793 Phase 1 Darunavir;Ritonavir;Beclomethasone Dipropionate HFA
44 Metabolic and Endocrine Effects of Repeated Epidural and Sacroiliac Joint Corticosteroid Injections Unknown status NCT01717430
45 Prevalence Study of Adrenal Suppression After Corticosteroids During Chemotherapy Completed NCT01209507
46 Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi Syndrome Completed NCT02368379 Not Applicable
47 Adrenal Suppression and Adrenal Recovery Induced by Megestrol Acetate Completed NCT00575029 Not Applicable megestrol acetate
48 Intra-articular Betamethasone and the Hypothalamic-pituitary-adrenal Axis Completed NCT01799408
49 Does Intravitreal Injection of Triamcinolone Acetonide Impairs the Adrenal Function Completed NCT00561236
50 Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis Completed NCT00552487 Not Applicable synacthen

Search NIH Clinical Center for Secondary Adrenal Insufficiency

Genetic Tests for Secondary Adrenal Insufficiency

Anatomical Context for Secondary Adrenal Insufficiency

MalaCards organs/tissues related to Secondary Adrenal Insufficiency:

41
Pituitary, Brain, Adrenal Gland, Testes, Spinal Cord, Kidney, Pancreas

Publications for Secondary Adrenal Insufficiency

Articles related to Secondary Adrenal Insufficiency:

(show top 50) (show all 106)
# Title Authors Year
1
Secondary adrenal insufficiency in pregnancy: any differences? ( 29546743 )
2018
2
Evaluation of the frequency of adrenal crises and preventive measures in patients with primary and secondary adrenal insufficiency in Switzerland. ( 29376554 )
2018
3
Nivolumab-induced Hypophysitis, Secondary Adrenal Insufficiency and Destructive Thyroiditis in a Patient with Lung Adenocarcinoma: A Case Report. ( 30449786 )
2018
4
Secondary Adrenal Insufficiency after Treatment with Budesonide for Autoimmune Hepatitis. ( 30386198 )
2018
5
Glycometabolic Alterations in Secondary Adrenal Insufficiency: Does Replacement Therapy Play a Role? ( 30123187 )
2018
6
Secondary adrenal insufficiency and pituitary dysfunction in oral/transdermal opioid users with non-cancer pain. ( 30324794 )
2018
7
Continuous subcutaneous hydrocortisone infusion in a woman with secondary adrenal insufficiency. ( 30353412 )
2018
8
Long-acting intramuscular ACTH stimulation test for the diagnosis of secondary adrenal insufficiency in children. ( 30530907 )
2018
9
Characterization of Cortisol Secretion Rate in Secondary Adrenal Insufficiency. ( 29264545 )
2017
10
Secondary adrenal insufficiency: from the physiopathology to the possible role of modified-release hydrocortisone treatment. ( 28750490 )
2017
11
Primary Hypothyroid and Secondary Adrenal Insufficiency-Searching the Missing Link. ( 28571201 )
2017
12
Secondary Adrenal Insufficiency Due to the Co-Administration of Ritonavir and Inhaled Fluticasone Propionate: Case report. ( 29062559 )
2017
13
GroupA 1. Epidemiology of primary and secondary adrenal insufficiency: Prevalence and incidence, acute adrenal insufficiency, long-term morbidity and mortality. ( 29174931 )
2017
14
Gastric cancer with pituitary metastasis presenting as symptomatic secondary adrenal insufficiency: A case report. ( 28421712 )
2017
15
A case of stiff-person syndrome due to secondary adrenal insufficiency. ( 28552871 )
2017
16
Two cases of late-onset secondary adrenal insufficiency after discontinuation of nivolumab. ( 28945828 )
2017
17
A Case of Psychosis in a Patient with Secondary Adrenal Insufficiency: A Possible Etiological Role of a Hypocortisolemic-induced Increase in Proinflammatory Cytokines. ( 29344425 )
2017
18
National German Audit of Diagnosis, Treatment, and Teaching in Secondary Adrenal Insufficiency. ( 28351092 )
2017
19
Somatosensory function in patients with secondary adrenal insufficiency treated with two different doses of hydrocortisone-Results from a randomized controlled trial. ( 28686664 )
2017
20
Secondary Adrenal Insufficiency Following Nivolumab Therapy in a Patient with Metastatic Renal Cell Carcinoma. ( 28871578 )
2017
21
"Petrified Ears" in Secondary Adrenal Insufficiency. ( 27042511 )
2016
22
Mifepristone Accelerates HPA Axis Recovery in Secondary Adrenal Insufficiency. ( 27516913 )
2016
23
Recovery of adrenal function after chronic secondary adrenal insufficiency in patients with hypopituitarism. ( 26928716 )
2016
24
Large-Dose Glucocorticoid Induced Secondary Adrenal Insufficiency in Spinal Cord Injury. ( 28119833 )
2016
25
Esophageal eosinophilia in secondary adrenal insufficiency. ( 27186162 )
2016
26
Secondary Adrenal Insufficiency: Where Is It Hidden and What Does It Look Like? ( 27211575 )
2016
27
Recovery of Adrenal Function in Patients with Glucocorticoids Induced Secondary Adrenal Insufficiency. ( 26676337 )
2016
28
Reversible Cardiomyopathy Accompanied by Secondary Adrenal Insufficiency. ( 26920218 )
2016
29
Pituitary Antibodies in an Adolescent with Secondary Adrenal Insufficiency and Turner Syndrome. ( 27355580 )
2016
30
Modified-release hydrocortisone decreases BMI and HbA1c in patients with primary and secondary adrenal insufficiency. ( 25656494 )
2015
31
Concomitant giant cell arteritis and secondary adrenal insufficiency. ( 26169623 )
2015
32
Takotsubo cardiomyopathy in a patient with pituitary adenoma and secondary adrenal insufficiency. ( 26816449 )
2015
33
Hyponatremia due to Secondary Adrenal Insufficiency Successfully Treated by Dexamethasone with Sodium Chloride. ( 26319655 )
2015
34
Opioid-induced secondary adrenal insufficiency presenting as hypercalcaemia. ( 26161260 )
2015
35
A Case of Primary and Secondary Adrenal Insufficiency in Children. ( 26092585 )
2015
36
Phosphoglucomutase-1 deficiency: Intrafamilial clinical variability and common secondary adrenal insufficiency. ( 26768186 )
2015
37
Secondary adrenal insufficiency: an overlooked cause of hyponatremia. ( 25699130 )
2015
38
Acute psychosis in the course of treatment of acute adrenal crisis with hydrocortisone in the patient with secondary adrenal insufficiency - a case study. ( 26488344 )
2015
39
Primary vs secondary adrenal insufficiency: ACTH-stimulated aldosterone diagnostic cut-off values by tandem mass spectrometry. ( 25620457 )
2015
40
The effects of two different doses of hydrocortisone on cognition in patients with secondary adrenal insufficiency--results from a randomized controlled trial. ( 25705800 )
2015
41
Inhaled corticosteroids and secondary adrenal insufficiency. ( 25674179 )
2014
42
Acute secondary adrenal insufficiency as the presenting manifestation of small-cell lung carcinoma. ( 24532238 )
2014
43
Iatrogenic Cushing syndrome and secondary adrenal insufficiency related to concomitant triamcinolone and ritonavir administration: a case report and review. ( 25513635 )
2014
44
Iatrogenic Cushing syndrome and secondary adrenal insufficiency related to concomitant triamcinolone and ritonavir administration: a case report and review. ( 23778239 )
2014
45
Health-related quality of life in primary and secondary adrenal insufficiency. ( 25252879 )
2014
46
Flexion contractures of the legs as the manifestation of secondary adrenal insufficiency due to Sheehan's syndrome. ( 22996815 )
2014
47
Secondary adrenal insufficiency after glucocorticosteroid administration in acute spinal cord injury: a case report. ( 24969098 )
2014
48
Severe hyponatremia caused by secondary adrenal insufficiency in a patient with giant pituitary prolactinoma. ( 28509288 )
2013
49
Chemotherapy-induced regression of an adrenocorticotropin-secreting pituitary carcinoma accompanied by secondary adrenal insufficiency. ( 24455332 )
2013
50
Topical corticosteroids and secondary adrenal insufficiency: a relationship in the shade. ( 24076040 )
2013

Variations for Secondary Adrenal Insufficiency

Expression for Secondary Adrenal Insufficiency

Search GEO for disease gene expression data for Secondary Adrenal Insufficiency.

Pathways for Secondary Adrenal Insufficiency

Pathways related to Secondary Adrenal Insufficiency according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.35 IGF1 IGFBP3 INS
2
Show member pathways
11.63 IGF1 INS
3 11.6 IGF1 INS
4 11.58 IGF1 INS
5 11.43 IGF1 INS
6 11.09 IGF1 INS
7 11.01 IGF1 INS
8 10.94 IGF1 INS
9 10.82 IGF1 IGFBP3 INS
10 10.72 IGF1 INS
11 10.28 IGF1 IGFBP3

GO Terms for Secondary Adrenal Insufficiency

Cellular components related to Secondary Adrenal Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 AVP IGF1 IGFBP3 INS
2 extracellular region GO:0005576 9.55 AVP IGF1 IGFBP3 INS PGM1
3 insulin-like growth factor ternary complex GO:0042567 8.96 IGF1 IGFBP3
4 insulin-like growth factor binding protein complex GO:0016942 8.62 IGF1 IGFBP3

Biological processes related to Secondary Adrenal Insufficiency according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.72 AVP IGF1 INS
2 regulation of signaling receptor activity GO:0010469 9.69 AVP IGF1 INS
3 positive regulation of gene expression GO:0010628 9.67 AVP IGF1 INS
4 positive regulation of cell growth GO:0030307 9.56 AVP INS
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.54 IGF1 INS
6 cellular protein metabolic process GO:0044267 9.54 IGF1 IGFBP3 INS
7 glucose metabolic process GO:0006006 9.52 INS PGM1
8 activation of protein kinase B activity GO:0032148 9.48 IGF1 INS
9 positive regulation of glucose import GO:0046326 9.46 IGF1 INS
10 ERK1 and ERK2 cascade GO:0070371 9.43 AVP IGF1
11 positive regulation of mitotic nuclear division GO:0045840 9.4 IGF1 INS
12 positive regulation of glycolytic process GO:0045821 9.32 IGF1 INS
13 negative regulation of release of cytochrome c from mitochondria GO:0090201 9.26 AVP IGF1
14 positive regulation of glycogen biosynthetic process GO:0045725 9.16 IGF1 INS
15 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.96 IGF1 IGFBP3
16 positive regulation of MAPK cascade GO:0043410 8.8 IGF1 IGFBP3 INS

Molecular functions related to Secondary Adrenal Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.16 IGF1 INS
2 insulin-like growth factor receptor binding GO:0005159 8.96 IGF1 INS
3 hormone activity GO:0005179 8.8 AVP IGF1 INS

Sources for Secondary Adrenal Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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