MCID: SCN069
MIFTS: 33

Secondary Hemophagocytic Lymphohistiocytosis

Categories: Blood diseases, Genetic diseases, Immune diseases, Liver diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Secondary Hemophagocytic Lymphohistiocytosis

MalaCards integrated aliases for Secondary Hemophagocytic Lymphohistiocytosis:

Name: Secondary Hemophagocytic Lymphohistiocytosis 58
Acquired Hemophagocytic Lymphohistiocytosis 58
Reactive Hemophagocytic Syndrome 58

Classifications:

Orphanet: 58  
Rare immunological diseases


External Ids:

UMLS via Orphanet 72 C0019068
Orphanet 58 ORPHA158041

Summaries for Secondary Hemophagocytic Lymphohistiocytosis

MalaCards based summary : Secondary Hemophagocytic Lymphohistiocytosis, also known as acquired hemophagocytic lymphohistiocytosis, is related to brucellosis and bacterial pneumonia. An important gene associated with Secondary Hemophagocytic Lymphohistiocytosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways is Circadian rythm related genes. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include t cells, liver and b cells, and related phenotypes are muscle and respiratory system

Related Diseases for Secondary Hemophagocytic Lymphohistiocytosis

Diseases in the Hemophagocytic Lymphohistiocytosis family:

Hemophagocytic Lymphohistiocytosis, Familial, 1 Hemophagocytic Lymphohistiocytosis, Familial, 4
Hemophagocytic Lymphohistiocytosis, Familial, 2 Hemophagocytic Lymphohistiocytosis, Familial, 3
Hemophagocytic Lymphohistiocytosis, Familial, 5 Secondary Hemophagocytic Lymphohistiocytosis
Primary Hemophagocytic Lymphohistiocytosis

Diseases related to Secondary Hemophagocytic Lymphohistiocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 170, show less)
# Related Disease Score Top Affiliating Genes
1 brucellosis 30.1 TNF ADA
2 bacterial pneumonia 29.8 TNF ADA
3 sarcoidosis 1 29.8 TNF ADA
4 chronic granulomatous disease 29.8 TNF ADA
5 miliary tuberculosis 29.6 TNF ADA
6 diffuse large b-cell lymphoma 29.6 TNF EZH2
7 acquired immunodeficiency syndrome 29.5 TNF ADA
8 end stage renal failure 29.5 TNF ADA
9 lymphoma, non-hodgkin, familial 29.2 TNF EZH2 ADA
10 immune deficiency disease 29.1 TNF ADA
11 human immunodeficiency virus type 1 29.1 TNF ADA
12 acquired hemophagocytic lymphohistiocytosis associated with malignant disease 12.6
13 macrophage activation syndrome 11.9
14 hemophagocytic lymphohistiocytosis 11.0
15 autoimmune disease 10.5
16 splenomegaly 10.5
17 pancytopenia 10.4
18 thrombocytopenia 10.4
19 hypertriglyceridemia, familial 10.4
20 histiocytosis 10.4
21 juvenile rheumatoid arthritis 10.4
22 lymphoma 10.3
23 lymphoma, hodgkin, classic 10.2
24 langerhans cell histiocytosis 10.2
25 kala-azar 1 10.2
26 kawasaki disease 10.2
27 neutropenia 10.2
28 toxic shock syndrome 10.2
29 adult-onset still's disease 10.2
30 b-cell lymphoma 10.2
31 leishmaniasis 10.2
32 systemic onset juvenile idiopathic arthritis 10.2
33 acute liver failure 10.2
34 chediak-higashi syndrome 10.2
35 griscelli syndrome 10.2
36 systemic lupus erythematosus 10.2
37 lysosomal acid lipase deficiency 10.2
38 dengue virus 10.2
39 leukemia 10.2
40 cholestasis 10.2
41 rheumatic disease 10.2
42 histoplasmosis 10.2
43 leptospirosis 10.2
44 avian influenza 10.2
45 visceral leishmaniasis 10.2
46 cytomegalovirus infection 10.2
47 lupus erythematosus 10.1
48 myeloma, multiple 10.0
49 dermatomyositis 10.0
50 complex partial epilepsy 10.0
51 focal epilepsy 10.0
52 liver disease 10.0
53 pneumonia 10.0
54 renal cell carcinoma, nonpapillary 10.0
55 thyroid cancer, nonmedullary, 1 10.0
56 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
57 weaver syndrome 10.0
58 wilms tumor 5 10.0
59 leukemia, acute myeloid 10.0
60 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
61 malaria 10.0
62 leukemia, acute lymphoblastic 10.0
63 graft-versus-host disease 10.0
64 bacterial sepsis 10.0
65 korean hemorrhagic fever 10.0
66 exanthem 10.0
67 lymphoproliferative syndrome 10.0
68 osteonecrosis 10.0
69 ehrlichiosis 10.0
70 endocarditis 10.0
71 lymphocytic leukemia 10.0
72 bacterial infectious disease 10.0
73 q fever 10.0
74 respiratory failure 10.0
75 disseminated intravascular coagulation 10.0
76 hantavirus hemorrhagic fever with renal syndrome 10.0
77 lemierre's syndrome 10.0
78 pulmonary alveolar proteinosis 10.0
79 dengue disease 10.0
80 dengue hemorrhagic fever 10.0
81 hepatitis a 10.0
82 typhoid fever 10.0
83 oral candidiasis 10.0
84 capillary leak syndrome 10.0
85 panniculitis 10.0
86 cholecystitis 10.0
87 autoimmune hepatitis 10.0
88 intestinal perforation 10.0
89 nocardiosis 10.0
90 bilirubin metabolic disorder 10.0
91 thyroid gland papillary carcinoma 10.0
92 gastritis 10.0
93 mucormycosis 10.0
94 lung disease 10.0
95 herpes simplex 10.0
96 malignant histiocytosis 10.0
97 measles 10.0
98 myeloid leukemia 10.0
99 ezh2-related overgrowth 10.0
100 acute graft versus host disease 10.0
101 meningococcemia 10.0
102 t-cell/histiocyte rich large b cell lymphoma 10.0
103 virus associated hemophagocytic syndrome 10.0
104 rapidly involuting congenital hemangioma 10.0
105 hemophagocytic syndrome associated with an infection 10.0
106 primary hemophagocytic lymphohistiocytosis 10.0
107 acute sensory ataxic neuropathy 10.0
108 secondary pulmonary alveolar proteinosis 10.0
109 histiocytic sarcoma 10.0
110 cytophagic histiocytic panniculitis 10.0
111 overgrowth syndrome 10.0
112 autoinflammatory syndrome 10.0
113 thyroid carcinoma 10.0
114 peripheral t-cell lymphoma 10.0
115 connective tissue disease 10.0
116 polyarteritis nodosa 10.0
117 listeria meningitis 9.9 TNF ADA
118 meningitis 9.9 TNF ADA
119 gastrointestinal tuberculosis 9.9 TNF ADA
120 abdominal tuberculosis 9.9 TNF ADA
121 tuberculous meningitis 9.9 TNF ADA
122 pleural tuberculosis 9.9 TNF ADA
123 pericardium disease 9.9 TNF ADA
124 chickenpox 9.9 TNF ADA
125 extrapulmonary tuberculosis 9.9 TNF ADA
126 pulmonary tuberculosis 9.9 TNF ADA
127 aseptic meningitis 9.9 TNF ADA
128 pleurisy 9.9 TNF ADA
129 pericarditis 9.9 TNF ADA
130 pleural disease 9.9 TNF ADA
131 primary bacterial infectious disease 9.9 TNF ADA
132 peritonitis 9.9 TNF ADA
133 omenn syndrome 9.9 TNF ADA
134 pfeiffer syndrome 9.8
135 scleroderma, familial progressive 9.8
136 hemophagocytic lymphohistiocytosis, familial, 1 9.8
137 nasopharyngeal carcinoma 9.8
138 cyanosis, transient neonatal 9.8
139 aspergillosis 9.8
140 myelodysplastic syndrome 9.8
141 inflammatory bowel disease 9.8
142 atrioventricular block 9.8
143 thrombotic thrombocytopenic purpura 9.8
144 strongyloidiasis 9.8
145 cardiac tamponade 9.8
146 nephrotic syndrome 9.8
147 pulmonary sarcoidosis 9.8
148 candidiasis 9.8
149 thrombocytosis 9.8
150 cervicitis 9.8
151 membranoproliferative glomerulonephritis 9.8
152 glomerulonephritis 9.8
153 acute kidney failure 9.8
154 purpura 9.8
155 mixed connective tissue disease 9.8
156 liver cirrhosis 9.8
157 hemolytic anemia 9.8
158 viral encephalitis 9.8
159 herpes zoster 9.8
160 pityriasis lichenoides 9.8
161 viral hemorrhagic fever 9.8
162 human immunodeficiency virus infectious disease 9.8 TNF ADA
163 mycobacterium tuberculosis 1 9.8 TNF ADA
164 behcet syndrome 9.8 TNF ADA
165 common variable immunodeficiency 9.7 TNF ADA
166 essential thrombocythemia 9.6 TNF EZH2
167 mantle cell lymphoma 9.6 TNF EZH2
168 breast adenocarcinoma 9.6 TNF EZH2
169 myelofibrosis 9.5 TNF EZH2
170 leukemia, chronic lymphocytic 9.3 TNF EZH2 ADA

Graphical network of the top 20 diseases related to Secondary Hemophagocytic Lymphohistiocytosis:



Diseases related to Secondary Hemophagocytic Lymphohistiocytosis

Symptoms & Phenotypes for Secondary Hemophagocytic Lymphohistiocytosis

MGI Mouse Phenotypes related to Secondary Hemophagocytic Lymphohistiocytosis:

45 (showing 2, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.13 ADA EZH2 TNF
2 respiratory system MP:0005388 8.8 ADA EZH2 TNF

Drugs & Therapeutics for Secondary Hemophagocytic Lymphohistiocytosis

Drugs for Secondary Hemophagocytic Lymphohistiocytosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 56, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
3
Etoposide Approved Phase 3 33419-42-0 36462
4
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
5
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
6
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
7
leucovorin Approved Phase 3 58-05-9 6006 143
8
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
9
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
10
Busulfan Approved, Investigational Phase 3 55-98-1 2478
11
Mycophenolic acid Approved Phase 3 24280-93-1 446541
12
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
13 Antiemetics Phase 3
14 Gastrointestinal Agents Phase 3
15 Etoposide phosphate Phase 3
16 Immunologic Factors Phase 3
17 Anti-Infective Agents Phase 3
18 Autonomic Agents Phase 3
19 Hormone Antagonists Phase 3
20 Topoisomerase Inhibitors Phase 3
21 Cyclosporins Phase 3
22 Anti-Inflammatory Agents Phase 3
23 Dermatologic Agents Phase 3
24 Antifungal Agents Phase 3
25 Immunosuppressive Agents Phase 3
26 Antineoplastic Agents, Hormonal Phase 3
27 Antirheumatic Agents Phase 3
28 BB 1101 Phase 3
29 glucocorticoids Phase 3
30 Calcineurin Inhibitors Phase 3
31 Hormones Phase 3
32 Hydrocortisone hemisuccinate Phase 3
33 Hydrocortisone-17-butyrate Phase 3
34 Alkylating Agents Phase 3
35 Antibiotics, Antitubercular Phase 3
36 Hydrocortisone 17-butyrate 21-propionate Phase 3
37 Folic Acid Antagonists Phase 3
38 Antitubercular Agents Phase 3
39 Anti-Bacterial Agents Phase 3
40 Vitamin B Complex Phase 3
41 Vitamin B9 Phase 3
42 Folate Phase 3
43 Antilymphocyte Serum Phase 3
44 Antimetabolites Phase 3
45
Aldesleukin Approved Phase 1, Phase 2 110942-02-4, 85898-30-2
46 Interleukin-2 Phase 1, Phase 2
47 Analgesics, Non-Narcotic Phase 1, Phase 2
48 Anti-Retroviral Agents Phase 1, Phase 2
49 Antiviral Agents Phase 1, Phase 2
50 Analgesics Phase 1, Phase 2
51 Anti-HIV Agents Phase 1, Phase 2
52 HIV Protease Inhibitors Phase 1, Phase 2
53
protease inhibitors Phase 1, Phase 2
54 Rho(D) Immune Globulin
55 Immunoglobulins, Intravenous
56 gamma-Globulins

Interventional clinical trials:

(showing 4, show less)
# Name Status NCT ID Phase Drugs
1 Hemophagocytic Lymphohistiocytosis Unknown status NCT00334672 Phase 3 busulfan;cyclophosphamide;cyclosporine;dexamethasone;etoposide;methotrexate;mycophenolate mofetil;therapeutic hydrocortisone
2 Safety and Efficiency Study of Low-dose IL-2 Treatment in Macrophage Activation Syndrome Unknown status NCT02569463 Phase 1, Phase 2 Interleukin-2
3 Ruxolitinib Combined With Dexamethasone for Pediatric Refractory and Secondary Hemophagocytic Lymphohistiocytosis Recruiting NCT03795909 Phase 1, Phase 2 Ruxolitinib;Dexamethasone
4 Pilot Study of First-line Immunosuppressive Therapy Combined With Etoposide and Allogeneic Hematopoietic Cell Transplantation in Refractory/Reactivated Cases for Hemophagocytic Lymphohistiocytosis (HLH) in Adult Patients Terminated NCT01547143 IST and/or alloHCT

Search NIH Clinical Center for Secondary Hemophagocytic Lymphohistiocytosis

Genetic Tests for Secondary Hemophagocytic Lymphohistiocytosis

Anatomical Context for Secondary Hemophagocytic Lymphohistiocytosis

MalaCards organs/tissues related to Secondary Hemophagocytic Lymphohistiocytosis:

40
T Cells, Liver, B Cells, Thyroid, Myeloid, Bone, Bone Marrow

Publications for Secondary Hemophagocytic Lymphohistiocytosis

Articles related to Secondary Hemophagocytic Lymphohistiocytosis:

(showing 293, show less)
# Title Authors PMID Year
1
Macrophage Activation Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in Childhood Inflammatory Disorders: Diagnosis and Management. 61
31732958 2020
2
Benefit of Anakinra in Treating Pediatric Secondary Hemophagocytic Lymphohistiocytosis. 61
31513353 2020
3
Reevaluating the role of ferritin in the diagnosis of adult secondary hemophagocytic lymphohistiocytosis. 61
31991015 2020
4
Adult secondary hemophagocytic lymphohistiocytosis with cerebromeningeal symptoms early after allogeneic hematopoietic stem cell transplantation. 61
31933488 2020
5
Secondary Hemophagocytic Lymphohistiocytosis secondary to Dengue and leptospirosis : A rare case report. 61
31979873 2020
6
Resolution of secondary hemophagocytic lymphohistiocytosis after treatment with the JAK1/2 inhibitor ruxolitinib. 61
31821455 2019
7
[Clinical significance of secondary hemophagocytic lymphohistiocytosis with pleural effusion]. 61
32023738 2019
8
Risk factors of early death in adult patients with secondary hemophagocytic lymphohistiocytosis: a single-institution study of 171 Chinese patients. 61
31474196 2019
9
A rare complication of systemic lupus erythematosus in a 9-year-old girl: Questions. 61
31823041 2019
10
Pediatric macrophage activation syndrome, recognizing the tip of the Iceberg. 61
31804174 2019
11
Respiratory failure and macrophage activation syndrome as an onset of systemic lupus erythematosus: A case report. 61
31799315 2019
12
Comparison between clinical features and prognosis of malignancy- and non-malignancy-associated pediatric hemophagocytic lymphohistiocytosis. 61
31783813 2019
13
Application of blood and immunodeficiency gene detection in the diagnosis of hemophagocytic lymphohistiocytosis patients. 61
31562900 2019
14
Senescence-accelerated mice (SAMP1/TA-1) treated repeatedly with lipopolysaccharide develop a condition that resembles hemophagocytic lymphohistiocytosis. 61
30819910 2019
15
Successful treatment of diffuse large B-cell lymphoma with secondary hemophagocytic lymphohistiocytosis by R-CHOP-E regimen: a case report. 61
31642356 2019
16
Ruxolitinib for secondary hemophagocytic lymphohistiocytosis: First case report. 61
28834694 2019
17
Hemophagocytic lymphohistiocytosis: A rare, potentially fatal complication in subcutaneous panniculitis like T cell lymphoma. 61
30289114 2019
18
Fatal case of TAFRO syndrome associated with over-immunosuppression: a case report and review of the literature. 61
31579342 2019
19
Fatal familial hemophagocytic lymphohistiocytosis with perforin gene (PRF1) mutation and EBV-associated T-cell lymphoproliferative disorder of the thyroid. 61
31440481 2019
20
Effectiveness of therapeutic plasma exchange in a critically ill child with secondary hemophagocytic lymphohistiocytosis. 61
31896925 2019
21
Etiologies and Clinical Outcomes of Patients With Secondary Hemophagocytic Lymphohistiocytosis at a Tertiary PICU. 61
31149968 2019
22
Human ehrlichiosis at a tertiary-care academic medical center: Clinical associations and outcomes of transplant patients and patients with hemophagocytic lymphohistiocytosis. 61
30913447 2019
23
[Clinical analysis of secondary hemophagocytic lymphohistiocytosis complicated with capillary leak syndrome]. 61
31340624 2019
24
Hemorrhagic fever with renal syndrome with secondary hemophagocytic lymphohistiocytosis in West China: a case report. 61
31164087 2019
25
Dengue infection complicated by hemophagocytic lymphohistiocytosis: Experiences from 180 severe dengue patients. 61
31188423 2019
26
Fludarabine/Melphalan 100 mg/m2 Conditioning Therapy Followed by Allogeneic Hematopoietic Cell Transplantation for Adult Patients with Secondary Hemophagocytic Lymphohistiocytosis. 61
30508593 2019
27
An unusual presentation of purine nucleoside phosphorylase deficiency mimicking systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome. 61
31118063 2019
28
Treatment of refractory secondary hemophagocytic lymphohistiocytosis with umbilical cord mesenchymal stem cells. 61
30961409 2019
29
The inhibitory receptors on NK cells and CTLs are upregulated in adult and adolescent patients with secondary hemophagocytic lymphohistiocytosis. 61
30914280 2019
30
An Elusive Diagnosis: Case Reports of Secondary Hemophagocytic Lymphohistiocytosis and Review of Current Literature. 61
31275772 2019
31
A Novel Mutation c.153 C>A in a Tunisian Girl With Wolman Disease and Unusual Presentation: Hemophagocytic Lymphohistiocytosis. 61
29702543 2019
32
Prevalence and Outcome of Secondary Hemophagocytic Lymphohistiocytosis Among SIRS Patients: Results from a Prospective Cohort Study. 61
31010216 2019
33
The Performance of Diagnostic Criteria for Hemophagocytic Lymphohistiocytosis in Critically Ill Patients. 61
30862243 2019
34
A multicenter study of patients with multisystem Langerhans cell histiocytosis who develop secondary hemophagocytic lymphohistiocytosis. 61
30521100 2019
35
Secondary hemophagocytic lymphohistiocytosis in pediatric patients: a single center experience and factors that influenced patient prognosis. 61
30821552 2019
36
Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice. 61
30674681 2019
37
Treatment outcomes and prognostic factors in adult patients with secondary hemophagocytic lymphohistiocytosis not associated with malignancy. 61
30213834 2019
38
T-cell lymphoma with secondary hemophagocytic lymphohistiocytosis as a rare cause of acute liver failure T-cell lymphoma as a cause of acute liver failure. 61
30553939 2019
39
Lysosomal Acid Lipase: From Cellular Lipid Handler to Immunometabolic Target. 61
30665623 2019
40
The interferon-gamma pathway is selectively up-regulated in the liver of patients with secondary hemophagocytic lymphohistiocytosis. 61
31846457 2019
41
The Immunology of Macrophage Activation Syndrome. 61
30774631 2019
42
Secondary Hemophagocytic Lymphohistiocytosis: A Challenging Diagnosis in a Patient with Autoimmune Hepatitis. 61
30863647 2019
43
Talaromycosis-Associated Secondary Hemophagocytic Lymphohistiocytosis in Nine Human Immunodeficiency Virus-Negative Patients: A Multicenter Retrospective Study. 61
31824178 2019
44
A rare case of hepatosplenic gamma-delta T-cell lymphoma and secondary hemophagocytic lymphohistiocytosis. 61
30656034 2019
45
A Catastrophic Presentation of Enteric Fever with Secondary Hemophagocytic Lymphohistiocytosis. 61
31313557 2018
46
A Case of Human Immunodeficiency Virus -triggered Hemophagocytic Lymphohistocytosis Presenting with Severe Bleeding Tendency. 61
31668025 2018
47
Reactive hemophagocytic syndrome in the setting of acute human immunodeficiency virus 1 infection: case report and review of the literature. 61
30114998 2018
48
Early onset lysosomal acid lipase deficiency presenting as secondary hemophagocytic lymphohistiocytosis: Two infants treated with sebelipase alfa. 61
29705274 2018
49
Prognostic Factors and Outcomes in Adults With Secondary Hemophagocytic Lymphohistiocytosis: A Single-center Experience. 61
30037588 2018
50
Fueling the FIRES: Hemophagocytic lymphohistiocytosis in febrile infection-related epilepsy syndrome. 61
30132834 2018
51
Differentiation between incomplete Kawasaki disease and secondary hemophagocytic lymphohistiocytosis following Kawasaki disease using N-terminal pro-brain natriuretic peptide. 61
29853942 2018
52
Childhood Visceral Leishmaniasis: Distinctive Features and Diagnosis of a Re-emerging Disease. An 11-year Experience From a Tertiary Referral Center in Athens, Greece. 61
28938257 2018
53
Hypofibrinogenemia Is Associated With Poor Outcome and Secondary Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome in Pediatric Severe Sepsis. 61
29470247 2018
54
Ruxolitinib as first-line treatment in secondary hemophagocytic lymphohistiocytosis: A second experience. 61
29417621 2018
55
Fatal meningococcal septicemia without meningeal signs, contribution of the peripheral smear in diagnosis: Report of a case. 61
29676380 2018
56
Diagnostic and management of life-threatening Adult-Onset Still Disease: a French nationwide multicenter study and systematic literature review. 61
29642928 2018
57
Allogeneic hematopoietic stem cell transplantation for severe, refractory juvenile idiopathic arthritis. 61
29618462 2018
58
Neonatal Adenovirus Infection Complicated by Hemophagocytic Lymphohistiocytosis Syndrome. 61
29610175 2018
59
A First Report of Secondary Hemophagocytic Lymphohistiocytosis Associated With Papillary Thyroid Carcinoma. 61
29087969 2018
60
Potentially Toxic Chemotherapy in Secondary Hemophagocytic Lymphohistiocytosis Patients That Could Have Been Replaced by Less Immunosuppressive Therapy. 61
28926358 2018
61
A reminder of the place of morphology and the H-score in the diagnosis of hemophagocytic lymphohistiocytosis (HLH). 61
29531733 2018
62
Ruxolitinib as first-line treatment in secondary hemophagocytic lymphohistiocytosis: A single patient experience. 61
29134683 2018
63
Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis. 61
29515924 2018
64
A Case of Spontaneously Improving Secondary Hemophagocytic Lymphohistiocytosis in an Adult Associated with T-Cell Histiocyte-Rich Large B-Cell Lymphoma. 61
29682376 2018
65
The influence of various therapeutic regimens on early clinical and laboratory response and outcome of children with secondary hemophagocytic lymphohistiocytosis. 61
29379544 2018
66
Secondary hemophagocytic lymphohistiocytosis in a child with Leptospira infection: A case report. 61
31365212 2018
67
[Clinical significance of serum calcium and albumin in patients with secondary hemophagocytic lymphohistiocytosis]. 61
29365395 2017
68
Lytic viral replication and immunopathology in a cytomegalovirus-induced mouse model of secondary hemophagocytic lymphohistiocytosis. 61
29258535 2017
69
Successful management of a complicated clinical crisis: A patient with left-sided endocarditis and secondary hemophagocytic lymphohistiocytosis: a rare case report and literature review. 61
29390580 2017
70
Human Bocavirus: Can It Trigger Hemophagocytic Lymphohistiocytosis? 61
28731923 2017
71
A Personalized Diagnostic and Treatment Approach for Macrophage Activation Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in Adults. 61
28871523 2017
72
[Reactive hemophagocytic syndrome]. 61
29064197 2017
73
A Novel Case of Pulmonary Nocardiosis with Secondary Hemophagocytic Lymphohistiocytosis. 61
28836562 2017
74
Kawasaki Disease Complicated With Macrophage Activation Syndrome: A Systematic Review. 61
28562511 2017
75
Mycobacterium iranicum bacteremia and hemophagocytic lymphohistiocytosis: a case report. 61
28789664 2017
76
Lemierre's Syndrome as a Trigger for Secondary Hemophagocytic Lymphohistiocytosis. 61
28085751 2017
77
Secondary Hemophagocytic Lymphohistiocytosis in an Infant with Wolman Disease. 61
27094156 2017
78
High concentration of miR-133 is a useful marker for the diagnosis of lymphoma- associated hemophagocytic syndrome. 61
28869447 2017
79
Reconstitution Inflammatory Syndrome Like Reactive Hemophagocytic Syndrome Associated with Disseminated Histoplasmosis in a HIV Patient. 61
28528522 2017
80
Sepsis due to Streptococcus pneumoniae associated with secondary hemophagocytic lymphohistiocytosis in a splenectomized patient for spherocytosis: A case report. 61
28700505 2017
81
Lymphoid malignancy-associated hemophagocytic lymphohistiocytosis: Search for the hidden source. 61
28648938 2017
82
Recent advances in diagnostic and therapeutic guidelines for primary and secondary hemophagocytic lymphohistiocytosis. 61
28433836 2017
83
Pulmonary Alveolar Proteinosis in Association with Secondary Hemophagocytic Lymphohistiocytosis. 61
28088396 2017
84
Tuberculosis-associated hemophagocytic lymphohistiocytosis with initial presentation of fever of unknown origin in a general hospital: An analysis of 8 clinical cases. 61
28422850 2017
85
Secondary hemophagocytic lymphohistiocytosis in the setting of metastatic renal cell carcinoma: a case report. 61
28249615 2017
86
Secondary Hemophagocytic Lymphohistiocytosis: Do We Really Need Chemotherapeutics for All Patients? 61
28060133 2017
87
Use of a mouse model to identify a blood biomarker for IFNγ activity in pediatric secondary hemophagocytic lymphohistiocytosis. 61
27559680 2017
88
Primary and secondary hemophagocytic lymphohistiocytosis have different patterns of T-cell activation, differentiation and repertoire. 61
27925643 2017
89
The Conundrum in the Diagnosis and Management of Atypical Fulminant Measles in a Leukemia Survivor on Maintenance Chemotherapy. 61
27992394 2017
90
Hemophagocytic syndrome masquerading as septic shock: An approach to such dilemma. 61
29318013 2017
91
Diffuse Large B-Cell Lymphoma with Secondary Hemophagocytic Lymphohistiocytosis Presenting as Acute Liver Failure. 61
28584842 2017
92
Severe dengue due to secondary hemophagocytic lymphohistiocytosis: A case study. 61
28409119 2017
93
Rituximab, etoposide, methylprednisolone, high-dose cytarabine, and cisplatin in the treatment of secondary hemophagocytic lymphohistiocytosis with classical Hodgkin lymphoma: a case report and review of the literature. 61
27998299 2016
94
An Unusual Case of LCHAD Deficiency Presenting With a Clinical Picture of Hemophagocytic Lymphohistiocytosis: Secondary HLH or Coincidence? 61
27769081 2016
95
Human monocytic ehrlichiosis complicated by hemophagocytic lymphohistiocytosis and multi-organ dysfunction syndrome. 61
27575459 2016
96
The Use of Ferritin to Identify Critically Ill Patients With Secondary Hemophagocytic Lymphohistiocytosis. 61
27441901 2016
97
Infection Associated Secondary Hemophagocytic Lymphohistiocytosis in Sepsis Syndromes - A Tip of an Iceberg. 61
27766802 2016
98
Acute HIV infection presenting as hemophagocytic syndrome with an unusual serological and virological response to ART. 61
27793107 2016
99
Use of Extracorporeal Support in Hemophagocytic Lymphohistiocytosis Secondary to Ehrlichiosis. 61
27633921 2016
100
Hemophagocytic lymphohistiocytosis triggered by Gaucher disease in a preterm neonate. 61
27922757 2016
101
High-Volume Hemofiltration in Critically Ill Patients With Secondary Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome: A Prospective Study in the PICU. 61
27487914 2016
102
Secondary hemophagocytic lymphohistiocytosis induced by cholecystitis: A case report and a review of the literature. 61
27423920 2016
103
18F-FDG PET/CT for identifying the potential causes and extent of secondary hemophagocytic lymphohistiocytosis. 61
27537853 2016
104
Liver transplantation for children with acute liver failure associated with secondary hemophagocytic lymphohistiocytosis. 61
27216884 2016
105
Toreforant, A Histamine H4 Receptor Antagonist, in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy: Results of 2 Phase II Studies. 61
27422891 2016
106
Hemophagocytosis in the Acute Phase of Fatal Kawasaki Disease in a 4 Month-Old Girl. 61
27606147 2016
107
Visceral leishmaniasis, hypertriglyceridemia and secondary hemophagocytic lymphohistiocytosis. 61
26872790 2016
108
[Expression of Serum HMGB-1 in Patients with Secondary Hemo-phagocytic Lymphohistiocytosis and Its Clinical Significance]. 61
27342526 2016
109
EZH2 mutation in an adolescent with Weaver syndrome developing acute myeloid leukemia and secondary hemophagocytic lymphohistiocytosis. 61
26762561 2016
110
Cytokine and viral load kinetics in human herpesvirus 8-associated multicentric Castleman's disease complicated by hemophagocytic lymphohistiocytosis. 61
26692197 2016
111
Mouse Cytomegalovirus Infection in BALB/c Mice Resembles Virus-Associated Secondary Hemophagocytic Lymphohistiocytosis and Shows a Pathogenesis Distinct from Primary Hemophagocytic Lymphohistiocytosis. 61
26903481 2016
112
[X-linked lymphoproliferative syndrome type 1 complicated with secondary hemophagocytic lymphohistiocytosis and ileal perforation: case report and literature review]. 61
27055430 2016
113
Viral etiology, clinical and laboratory features of adult hemophagocytic lymphohistiocytosis. 61
26287378 2016
114
Macrophage Activation Syndrome. 61
26400031 2016
115
Successful Treatment of Scrub Typhus-Associated Hemophagocytic Lymphohistiocytosis With Chloramphenicol: Report of 3 Pediatric Cases and Literature Review. 61
26937940 2016
116
IDO1 Deficiency Does Not Affect Disease in Mouse Models of Systemic Juvenile Idiopathic Arthritis and Secondary Hemophagocytic Lymphohistiocytosis. 61
26914138 2016
117
[Successful Treatment of Seasonal Influenza A (H3N2) infection-related Hemophagocytic Lymphocytosis in an Elderly Man]. 61
27032178 2016
118
[Pseudotumoral thoracic splenosis in a patient with adult-onset Still disease and reactive hemophagocytic syndrome]. 61
26433835 2015
119
Successful control of juvenile dermatomyositis-associated macrophage activation syndrome and interstitial pneumonia: distinct kinetics of interleukin-6 and -18 levels. 61
26581448 2015
120
Secondary Hemophagocytic Lymphohistiocytosis in a Patient With Favorable Histology Wilms Tumor. 61
26479988 2015
121
Disseminated mucormycosis-induced perforated intestine in a late presenting AIDS patient with steroid-dependent secondary hemophagocytic lymphohistiocytosis. 61
26544587 2015
122
Secondary hemophagocytic lymphohistiocytosis in children with brucellosis: report of three cases. 61
26517495 2015
123
Secondary Hemophagocytic Lymphohistiocytosis Associated with Epstein-Barr Virus. 61
25708060 2015
124
Elevated serum adenosine deaminase levels in secondary hemophagocytic lymphohistiocytosis. 61
25764155 2015
125
Prognostic Factors and Long-Term Outcome in 52 Turkish Children With Hemophagocytic Lymphohistiocytosis. 61
25901543 2015
126
How We Manage Hyperferritinemic Sepsis-Related Multiple Organ Dysfunction Syndrome/Macrophage Activation Syndrome/Secondary Hemophagocytic Lymphohistiocytosis Histiocytosis. 61
26154908 2015
127
Does Viral Hemorrhagic Fever Represent Reactive Hemophagocytic Syndrome? 61
26136549 2015
128
Epstein-Barr virus viral load in human immunodeficiency virus-positive patients with reactive hemophagocytic syndrome. 61
25746607 2015
129
Validity in the diagnosis of reactive hemophagocytic syndrome: comment on the article by Fardet et Al. 61
25370365 2015
130
Disseminated Histoplasmosis and Secondary Hemophagocytic Syndrome in a Non-HIV Patient. 61
26347828 2015
131
Clinical features and correct diagnosis of macrophage activation syndrome. 61
26082353 2015
132
Successful treatment of macrophage activation syndrome in a patient with dermatomyositis by combination with immunosuppressive therapy and plasmapheresis. 61
24252010 2015
133
[The clinical significance of serum neopterin and adenosine deaminase in patients with secondary hemophagocytic lymphohistiocytosis]. 61
25877146 2015
134
Reactive hemophagocytic syndrome in adult-onset Still disease: clinical features, predictive factors, and prognosis in 21 patients. 61
25634183 2015
135
Compartmentalized interleukin-1β in pulmonary secondary hemophagocytic lymphohistiocytosis. 61
25560292 2015
136
Progressive Diffuse Osteonecrosis in a Patient with Secondary Hemophagocytic Lymphohistiocytosis. 61
26693376 2015
137
Cytomegalovirus infections, kidney transplantation, and secondary hemophagocytic lymphohistiocytosis. 61
25219298 2014
138
Intense and diffuse lung uptake of 99mTc-MDP in a patient with pneumonia associated with secondary hemophagocytic lymphohistiocytosis. 61
24999696 2014
139
Reactive hemophagocytic syndrome in adults: a retrospective analysis of 162 patients. 61
24835040 2014
140
Cytology of secondary hemophagocytic lymphohistiocytosis masquerading as lymphoma in a nonimmunocompromised adult. 61
25745299 2014
141
Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. 61
24782338 2014
142
Disseminated herpes simplex virus manifesting as pyrexia and cervicitis and leading to reactive hemophagocytic syndrome in pregnancy. 61
24890680 2014
143
Reactive hemophagocytic syndrome in a patient with adult-onset Still disease. 61
25128133 2014
144
Macrophage activation syndrome secondary to human monocytic ehrlichiosis. 61
25332563 2014
145
Wolman's disease with secondary hemophagocytic lymphohistiocytosis. 61
24933302 2014
146
Secondary hemophagocytic lymphohistiocytosis (HLH) from a presumed brown recluse spider bite. 61
24737162 2014
147
Plasma exchange, methylprednisolone, IV immune globulin, and now anakinra support continued PICU equipoise in management of hyperferritinemia-associated sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome/secondary hemophagocytic lymphohistiocytosis syndrome*. 61
24892479 2014
148
Therapeutic role of anakinra, an interleukin-1 receptor antagonist, in the management of secondary hemophagocytic lymphohistiocytosis/sepsis/multiple organ dysfunction/macrophage activating syndrome in critically ill children*. 61
24583503 2014
149
A high sIL-2R/ferritin ratio is a useful marker for the diagnosis of lymphoma-associated hemophagocytic syndrome. 61
24705932 2014
150
Clinical implication of F-18 FDG PET/CT in patients with secondary hemophagocytic lymphohistiocytosis. 61
24061788 2014
151
Trichosporon asahii, sepsis, and secondary hemophagocytic lymphohistiocytosis in children with hematologic malignancy. 61
24383917 2014
152
Adult-onset still disease: manifestations, treatment, outcome, and prognostic factors in 57 patients. 61
24646465 2014
153
Hemophagocytic syndrome in patients with acute myeloid leukemia undergoing intensive chemotherapy. 61
24142998 2014
154
Diagnosis and classification of adult Still's disease. 61
24486119 2014
155
Marrow assessment for hemophagocytic lymphohistiocytosis demonstrates poor correlation with disease probability. 61
24343738 2014
156
Adult onset Still's disease with persistent skin lesions complicated by secondary hemophagocytic lymphohistiocytosis. 61
24119099 2014
157
Importance of hyperbilirubinemia in differentiation of primary and secondary hemophagocytic lymphohistiocytosis in pediatric cases. 61
25408853 2014
158
An Unusual Case of Adult-Onset Still's Disease with Hemophagocytic Syndrome, Necrotic Leukoencephalopathy and Disseminated Intravascular Coagulation. 61
24707428 2014
159
Secondary hemophagocytic lymphohistiocytosis possibly induced by interferon beta-1a therapy. 61
24399189 2013
160
Ehrlichiosis presenting with toxic shock-like syndrome and secondary hemophagocytic lymphohistiocytosis. 61
23808094 2013
161
Severe hemorrhagic coagulopathy with hemophagocytic lymphohistiocytosis secondary to Epstein-Barr virus-associated T-cell lymphoproliferative disorder. 61
23439459 2013
162
Human herpesvirus 8-related Castleman disease in the absence of HIV infection. 61
23223599 2013
163
Evaluation of the plasma micro RNA expression levels in secondary hemophagocytic lymphohistiocytosis. 61
24363881 2013
164
Hyperferritinemia in the critically ill child with secondary hemophagocytic lymphohistiocytosis/sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome: what is the treatment? 61
22715953 2012
165
Hemophagocytic lymphohistiocytosis associated with influenza A (H1N1) infection in a patient with chronic lymphocytic leukemia: an autopsy case report and review of the literature. 61
21724431 2012
166
Enteric Fever presenting as secondary hemophagocytic lymphohistiocytosis. 61
22415495 2012
167
Secondary hemophagocytic lymphohistiocytosis in adults: an update on diagnosis and therapy. 61
23271259 2012
168
Secondary hemophagocytic lymphohistiocytosis in zoonoses. A systematic review. 61
23104648 2012
169
Secondary hemophagocytic lymphohistiocytosis: forget me not! 61
22852815 2012
170
[A case of hemophagocytic lymphohistiocytosis syndrome caused by severe tuberculosis and literature review]. 61
23289995 2012
171
Measles and secondary hemophagocytic lymphohistiocytosis. 61
22931858 2012
172
Clinical analysis of macrophage activation syndrome in pediatric patients with autoimmune diseases. 61
22615046 2012
173
The significance of 18F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis. 61
22824539 2012
174
Clinical features of adult patients with secondary hemophagocytic lymphohistiocytosis from causes other than lymphoma: an analysis of treatment outcome and prognostic factors. 61
22147006 2012
175
Reactive hemophagocytic syndrome caused by Rickettsial infection: report of a case. 61
22709789 2012
176
Intravenous immunoglobulin treatment for macrophage activation syndrome complicating chronic granulomatous disease. 61
22119934 2012
177
Reactive hemophagocytic syndrome in adult Korean patients with systemic lupus erythematosus: a case-control study and literature review. 61
22174206 2012
178
Please, do not forget secondary hemophagocytic lymphohistiocytosis in HIV-infected patients. 61
22019569 2011
179
Splenectomy for an adult patient with refractory secondary hemophagocytic lymphohistiocytosis. 61
21873022 2011
180
Fulminant hemophagocytic lymphohistiocytosis induced by pandemic A (H1N1) influenza: a case report. 61
21722406 2011
181
Acquired hemophagocytic lymphohistiocytosis associated with multiple myeloma. 61
20358309 2011
182
Clinical characteristics of hemophagocytic lymphohistiocytosis related to Kawasaki disease. 61
21381871 2011
183
Brucellosis presenting with pancytopenia due to hemophagocytic syndrome. 61
27263945 2011
184
[Clinical analysis of 10 cases of secondary hemophagocytic lymphohistiocytosis treated with HLH-2004 chemotherapy]. 61
21176364 2010
185
Spontaneous resolution of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. 61
20806367 2010
186
Laboratory tests in the diagnosis and follow-up of pediatric rheumatic diseases: an update. 61
19246077 2010
187
A rare hematological manifestation of brucellosis: reactive hemophagocytic syndrome. 61
20457434 2010
188
[Reactive hemophagocytic syndrome. Is this condition underdiagnosed?]. 61
20172511 2010
189
Novel swine-origin influenza A (H1N1) virus-associated hemophagocytic syndrome--a first case report. 61
20348529 2010
190
Soluble components of Histoplasma capsulatum var. capsulatum have hemagglutinin activity and induce syngeneic hemophagocytosis in vitro. 61
19908162 2010
191
Chronic murine typhoid fever is a natural model of secondary hemophagocytic lymphohistiocytosis. 61
20195482 2010
192
Reactive hemophagocytic syndrome in adult-onset Still disease: clinical features and long-term outcome: a case-control study of 8 patients. 61
20075703 2010
193
Primary and secondary hemophagocytic lymphohistiocytosis: clinical features, pathogenesis and therapy. 61
20383897 2010
194
Early diagnostic value of low percentage of glycosylated ferritin in secondary hemophagocytic lymphohistiocytosis. 61
19655220 2009
195
Virus-Associated Hemophagocytic Syndrome related to acute CMV and HBV sexual co-infection: a case report. 61
19640781 2009
196
Pediatric acute lymphoblastic leukemia complicated by secondary hemophagocytic lymphohistiocytosis. 61
19459197 2009
197
Malignancy-associated hemophagocytic lymphohistiocytosis in pediatric cases: a multicenter study from Turkey. 61
19817262 2009
198
Secondary hemophagocytic lymphohistiocytosis and severe sepsis/ systemic inflammatory response syndrome/multiorgan dysfunction syndrome/macrophage activation syndrome share common intermediate phenotypes on a spectrum of inflammation. 61
19325510 2009
199
Systemic infection of avian influenza A virus H5N1 subtype in humans. 61
19121843 2009
200
An unusual cause of multiple organ dysfunction syndrome in the pediatric intensive care unit: hemophagocytic lymphohistiocytosis. 61
19433941 2009
201
Continuous hemodiafiltration in the treatment of reactive hemophagocytic syndrome refractory to medical therapy. 61
19097821 2009
202
[Diagnostic significance of glycosylated ferritin for patients with secondary hemophagocytic lymphohistiocytosis]. 61
19099648 2008
203
Reactive hemophagocytic syndrome. 61
18810357 2008
204
Successful treatment of secondary hemophagocytic lymphohistiocytosis in a patient with disseminated histoplasmosis. 61
18854090 2008
205
[Diagnostic significance of NK cell activity and soluble CD25 level in serum from patients with secondary hemophagocytic lymphohistiocytosis]. 61
18928616 2008
206
Reactive hemophagocytic syndrome treated with extracorporeal membrane oxygenation. 61
19261127 2008
207
Polyarteritis nodosa presenting as pancytopenia: case report and review of the literature. 61
18368407 2008
208
Hemophagocytic syndrome in miliary tuberculosis presenting with noncaseating granulomas in bone marrow and liver. 61
18583221 2008
209
[Destombes Rosaï Dorfman syndrome: description of one case and diagnostic challenges in the tropical setting]. 61
18478777 2008
210
Macrophage activation syndrome in rheumatic disease: what is the role of the antigen presenting cell? 61
18295734 2008
211
Ankylosing spondylitis presenting with macrophage activation syndrome. 61
17235650 2007
212
Ileal perforation and reactive hemophagocytic syndrome in a patient with disseminated histoplasmosis: the role of the real-time polymerase chain reaction in the diagnosis and successful treatment with amphotericin B lipid complex. 61
17141457 2007
213
Fatal reactive hemophagocytosis related to disseminated histoplasmosis with endocarditis: an unusual case diagnosed at autopsy. 61
17330695 2007
214
[Reactive hemophagocytic syndrome in critical care patients. Report of 4 cases]. 61
17408021 2007
215
Secondary hemophagocytic lymphohistiocytosis associated with meningococcemia. 61
17065145 2006
216
Tumor necrosis factor alpha promoter polymorphism associated with increased susceptibility to secondary hemophagocytic lymphohistiocytosis in the Korean population. 61
17166738 2006
217
Interleukin 1 receptor antagonist to treat cytophagic histiocytic panniculitis with secondary hemophagocytic lymphohistiocytosis. 61
17014024 2006
218
[A case of hemophagocytic syndrome with terminal ileal ulcerations]. 61
17047437 2006
219
Reactive hemophagocytic syndrome complicating the treatment of inflammatory bowel disease. 61
16804394 2006
220
A case of rhesus hemolytic disease with hemophagocytosis and severe iron overload due to multiple transfusions. 61
16772878 2006
221
Characteristics and long-term outcome of 15 episodes of systemic lupus erythematosus-associated hemophagocytic syndrome. 61
16721259 2006
222
Reactive hemophagocytic syndrome in a patient with polyarteritis nodosa associated with Epstein-Barr virus reactivation. 61
17073007 2006
223
Influenza pandemics: past, present and future. 61
16440064 2006
224
Reactive hemophagocytic syndrome in a case of systemic lupus erythematosus that was diagnosed by detection of hemophagocytosing macrophages in peripheral blood smears. 61
16767556 2006
225
Secondary hemophagocytic lymphohistiocytosis in Turkish children. 61
16371881 2005
226
[Acute pancreatitis associated with hemophagocytic syndrome in systemic lupus erythematous: a case report]. 61
16435516 2005
227
Cytomegalovirus-associated hemophagocytic syndrome in a patient with adult onset Still's disease. 61
15789896 2005
228
The macrophage activation syndrome: a new entity, a potentially fatal complication of rheumatic disorders. 61
16152767 2005
229
Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome. 61
15613100 2005
230
A case report of the effect of plasma exchange on reactive hemophagocytic syndrome associated with toxic shock syndrome. 61
15663552 2004
231
Hemophagocytic lymphohistiocytosis after chemotherapy for multiple myeloma. 61
15636696 2004
232
Favorable outcome in patients with renal involvement complicating macrophage activation syndrome in systemic onset juvenile rheumatoid arthritis. 61
15468377 2004
233
Secondary hemophagocytic lymphohistiocytosis induced by malaria infection in a child with Langerhans cell histiocytosis. 61
15202166 2004
234
Reactive hemophagocytic syndrome in adult systemic disease: report of twenty-six cases and literature review. 61
14558048 2003
235
Reactive hemophagocytic syndrome associated with disseminated histoplasmosis in a heart transplant recipient. 61
12681429 2003
236
Macrophage activation syndrome following initiation of etanercept in a child with systemic onset juvenile rheumatoid arthritis. 61
12563702 2003
237
[Reactive hemophagocytic syndrome: about one case]. 61
12604390 2003
238
Secondary hemophagocytic lymphohistiocytosis in children: an analysis of etiology and outcome. 61
12403229 2002
239
Thrombotic microangiopathy in hemophagocytic syndrome: a case report. 61
12101856 2002
240
Outbreak of avian influenza A(H5N1) virus infection in Hong Kong in 1997. 61
11938498 2002
241
Reactive hemophagocytic syndrome associated with thrombotic thrombocytopenic purpura during therapeutic plasma exchange. 61
11982958 2002
242
Two cases of reactive hemophagocytic syndrome: a patient with adult-onset Still's disease and a patient with herpes zoster and autoimmune abnormalities. 61
24383780 2001
243
[Panniculitis and macrophage activation syndrome in a child with lupus erythematosus]. 61
11908139 2001
244
Hemophagocytosis in autoimmune disease. 61
11407091 2001
245
Pathology of fatal human infection associated with avian influenza A H5N1 virus. 61
11170064 2001
246
Disseminated histoplasmosis with reactive hemophagocytosis: aspiration cytology findings in two cases. 61
11074651 2000
247
Successful treatment of reactive hemophagocytic syndrome by plasmapheresis and high-dose γ-globulin in a patient with systemic lupus erythematosus. 61
24383641 2000
248
[Intravenously administered gamma-globulins in reactive hemaphagocytic syndrome. Multicenter study to assess their importance, by the immunoglobulins group of experts of CEDIT of the AP-HP]. 61
11139652 2000
249
Reactive hemophagocytic syndrome presenting as a component of multiple organ dysfunction syndrome. 61
11009000 2000
250
Reactive hemophagocytic syndrome as a presenting feature of Hodgkin's disease. 61
10901612 2000
251
Successful treatment of reactive hemophagocytic syndrome with cyclosporin A and intravenous immunoglobulin. 61
10936988 2000
252
[Reactive hemophagocytic syndrome in children]. 61
10761606 2000
253
[Antiphospholipid antibody-associated hemophagocytic syndrome]. 61
10783662 2000
254
Successful bone marrow transplantation in an adult patient with reactive hemophagocytic syndrome associated with myelodysplastic syndrome. 61
10745629 2000
255
Recurrent viral associated hemophagocytic syndrome in a child with Langerhans cell histiocytosis. 61
10598673 1999
256
Aplastic anemia after Mycoplasma pneumoniae infection: a report of two cases. 61
10445893 1999
257
Marked histiocytosis in the portal tract in a patient with reactive hemophagocytic syndrome: An autopsy case. 61
10504532 1999
258
The spectrum of reactive hemophagocytic syndrome in systemic lupus erythematosus. 61
10229419 1999
259
[Polyvalent intravenous immunoglobulins in systemic lupus]. 61
10522315 1999
260
Biomarker and morphological characteristics of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis. 61
9722893 1998
261
Photo quiz. I. Reactive hemophagocytic syndrome caused by CMV infection. 61
9636849 1998
262
Response of Epstein-Barr virus-associated Ki-1+ anaplastic large cell lymphoma to 13-cis retinoic acid and interferon alpha. 61
9650472 1998
263
Infection- and malignancy-associated hemophagocytic syndromes. Secondary hemophagocytic lymphohistiocytosis. 61
9561911 1998
264
Reactive hemophagocytic syndrome associated with Penicillium marneffei infection. 61
9528739 1998
265
[Histiocytic cytophagic panniculitis]. 61
9537003 1997
266
[Hyperferritinemia in Still syndrome in the adult and reactive hemophagocytic syndrome]. 61
9340475 1997
267
Reactive hemophagocytic syndrome and Hodgkin's disease. 61
9136919 1997
268
Hemophagocytic syndrome (HPS) in children and adults. 61
9114593 1997
269
[Macrophage activation syndrome disclosing leukemic transformation of mycosis fungoides]. 61
9740849 1997
270
A study of the possible etiologic association of Epstein-Barr virus with reactive hemophagocytic syndrome in Hong Kong Chinese. 61
8912837 1996
271
Case report: reactive hemophagocytic syndrome associated with disseminated strongyloidiasis. 61
8686729 1996
272
[Human babesiosis in a patient after splenectomy]. 61
8637296 1996
273
[Hemophagocytic syndromes. A series of 23 cases]. 61
8796089 1996
274
Reactive hemophagocytic syndrome: a new presentation of disseminated histoplasmosis in patients with AIDS. 61
8749633 1995
275
[Reactive hemophagocytic syndrome responded to combination chemotherapy with steroid pulse therapy]. 61
8691575 1995
276
Hyperferritinemia in reactive hemophagocytic syndrome report of four adult cases. 61
7604819 1995
277
Aggressive pleomorphic CD2+, CD3-, CD56+ lymphoma with t(5;9)(q31;q34) abnormality. 61
7543014 1995
278
[A case of nephrotic syndrome mimicking membranoproliferative glomerulonephritis (MPGN) and associated with reactive hemophagocytic syndrome after renal death]. 61
7602813 1995
279
[Reactive hemophagocytic syndrome: a probably underestimated cause of thrombocytopenia in intensive acre patients]. 61
8745978 1995
280
[Reactive hemophagocytic syndrome with disseminated intravascular coagulation secondary to acute brucellosis]. 61
7865565 1994
281
Reactive hemophagocytic syndrome simulating acute hepatitis. A case due to hepatic peripheral T-cell lymphoma. 61
7806836 1994
282
Miliary tuberculosis with splenic rupture: a fatal case with hemophagocytic syndrome and possible association with long standing sarcoidosis. 61
7892057 1994
283
Reactive hemophagocytic syndrome: A report of two cases from Kuwait. 61
17586904 1994
284
Reactive hemophagocytic syndrome in childhood--frequent occurrence of atypical mononuclear cells. 61
8070755 1994
285
Large cell lymphoma with initial presentation in the bone marrow. 61
1493910 1992
286
Reactive hemophagocytic syndrome--a clinicopathologic study of 40 patients in an Oriental population. 61
1497014 1992
287
[The reactive hemophagocytic syndrome associated with immunoblastic B-cell lymphoma]. 61
1598430 1992
288
The acute lupus hemophagocytic syndrome. 61
1992881 1991
289
[The reactive hemophagocytic syndrome associated with infection: a study of 3 cases]. 61
2103268 1990
290
[Reactive hemophagocytic syndrome: analysis of a series of 7 cases]. 61
2325464 1990
291
Peripheral T-cell lymphoma presenting as hemophagocytic syndrome. 61
2786835 1989
292
Reactive hemophagocytic syndrome: a study of 7 fatal cases. 61
3588026 1987
293
Reactive hemophagocytic syndrome. 61
4095022 1985

Variations for Secondary Hemophagocytic Lymphohistiocytosis

Expression for Secondary Hemophagocytic Lymphohistiocytosis

Search GEO for disease gene expression data for Secondary Hemophagocytic Lymphohistiocytosis.

Pathways for Secondary Hemophagocytic Lymphohistiocytosis

Pathways related to Secondary Hemophagocytic Lymphohistiocytosis according to GeneCards Suite gene sharing:

(showing 1, show less)
# Super pathways Score Top Affiliating Genes

GO Terms for Secondary Hemophagocytic Lymphohistiocytosis

Biological processes related to Secondary Hemophagocytic Lymphohistiocytosis according to GeneCards Suite gene sharing:

(showing 5, show less)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.32 TNF EZH2
2 regulation of cell proliferation GO:0042127 9.26 TNF EZH2
3 regulation of protein phosphorylation GO:0001932 9.16 TNF EZH2
4 positive regulation of MAP kinase activity GO:0043406 8.96 TNF EZH2
5 embryonic digestive tract development GO:0048566 8.62 TNF ADA

Molecular functions related to Secondary Hemophagocytic Lymphohistiocytosis according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 8.62 TNF EZH2

Sources for Secondary Hemophagocytic Lymphohistiocytosis

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11 DGIdb
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