MCID: SCN069
MIFTS: 35

Secondary Hemophagocytic Lymphohistiocytosis

Categories: Blood diseases, Genetic diseases, Immune diseases, Liver diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Secondary Hemophagocytic Lymphohistiocytosis

MalaCards integrated aliases for Secondary Hemophagocytic Lymphohistiocytosis:

Name: Secondary Hemophagocytic Lymphohistiocytosis 59
Acquired Hemophagocytic Lymphohistiocytosis 59
Reactive Hemophagocytic Syndrome 59

Classifications:

Orphanet: 59  
Rare immunological diseases


External Ids:

UMLS via Orphanet 73 C0019068
Orphanet 59 ORPHA158041

Summaries for Secondary Hemophagocytic Lymphohistiocytosis

MalaCards based summary : Secondary Hemophagocytic Lymphohistiocytosis, also known as acquired hemophagocytic lymphohistiocytosis, is related to hemophagocytic lymphohistiocytosis and miliary tuberculosis. An important gene associated with Secondary Hemophagocytic Lymphohistiocytosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways is Circadian rythm related genes. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include t cells, liver and bone, and related phenotypes are embryo and endocrine/exocrine gland

Related Diseases for Secondary Hemophagocytic Lymphohistiocytosis

Diseases in the Hemophagocytic Lymphohistiocytosis family:

Hemophagocytic Lymphohistiocytosis, Familial, 1 Hemophagocytic Lymphohistiocytosis, Familial, 4
Hemophagocytic Lymphohistiocytosis, Familial, 2 Hemophagocytic Lymphohistiocytosis, Familial, 3
Hemophagocytic Lymphohistiocytosis, Familial, 5 Secondary Hemophagocytic Lymphohistiocytosis
Primary Hemophagocytic Lymphohistiocytosis

Diseases related to Secondary Hemophagocytic Lymphohistiocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 161, show less)
# Related Disease Score Top Affiliating Genes
1 hemophagocytic lymphohistiocytosis 31.2 TNF ADA
2 miliary tuberculosis 29.7 TNF ADA
3 human immunodeficiency virus type 1 29.1 TNF ADA
4 myelodysplastic syndrome 28.9 TNF EZH2
5 leukemia, acute myeloid 28.8 TNF EZH2
6 acquired hemophagocytic lymphohistiocytosis associated with malignant disease 12.6
7 macrophage activation syndrome 11.8
8 autoimmune disease 10.5
9 pancytopenia 10.4
10 splenomegaly 10.4
11 thrombocytopenia 10.4
12 hypertriglyceridemia, familial 10.4
13 histiocytosis 10.4
14 langerhans cell histiocytosis 10.2
15 kala-azar 1 10.2
16 neutropenia 10.2
17 toxic shock syndrome 10.2
18 adult-onset still's disease 10.2
19 juvenile rheumatoid arthritis 10.2
20 leishmaniasis 10.2
21 acute liver failure 10.2
22 systemic lupus erythematosus 10.2
23 chediak-higashi syndrome 10.2
24 griscelli syndrome 10.2
25 lymphoma, hodgkin, classic 10.2
26 lysosomal acid lipase deficiency 10.2
27 kawasaki disease 10.2
28 dengue virus 10.2
29 brucellosis 10.2
30 leukemia 10.2
31 cholestasis 10.2
32 histoplasmosis 10.2
33 avian influenza 10.2
34 b-cell lymphoma 10.2
35 visceral leishmaniasis 10.2
36 cytomegalovirus infection 10.2
37 lupus erythematosus 10.1
38 myeloma, multiple 10.0
39 dermatomyositis 10.0
40 complex partial epilepsy 10.0
41 focal epilepsy 10.0
42 chronic granulomatous disease 10.0
43 liver disease 10.0
44 pneumonia 10.0
45 hematopoietic stem cell transplantation 10.0
46 renal cell carcinoma, nonpapillary 10.0
47 sarcoidosis 1 10.0
48 thyroid cancer, nonmedullary, 1 10.0
49 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
50 hemophagocytic lymphohistiocytosis, familial, 1 10.0
51 weaver syndrome 10.0
52 wilms tumor 5 10.0
53 lymphoma, non-hodgkin, familial 10.0
54 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
55 malaria 10.0
56 leukemia, acute lymphoblastic 10.0
57 graft-versus-host disease 10.0
58 korean hemorrhagic fever 10.0
59 exanthem 10.0
60 diffuse large b-cell lymphoma 10.0
61 lymphoma 10.0
62 lymphoproliferative syndrome 10.0
63 osteonecrosis 10.0
64 ehrlichiosis 10.0
65 endocarditis 10.0
66 lymphocytic leukemia 10.0
67 bacterial infectious disease 10.0
68 q fever 10.0
69 respiratory failure 10.0
70 disseminated intravascular coagulation 10.0
71 hemorrhagic fever with renal syndrome 10.0
72 lemierre's syndrome 10.0
73 pulmonary alveolar proteinosis 10.0
74 dengue disease 10.0
75 dengue hemorrhagic fever 10.0
76 hepatitis a 10.0
77 typhoid fever 10.0
78 capillary leak syndrome 10.0
79 panniculitis 10.0
80 rheumatic disease 10.0
81 cholecystitis 10.0
82 autoimmune hepatitis 10.0
83 intestinal perforation 10.0
84 leptospirosis 10.0
85 nocardiosis 10.0
86 bilirubin metabolic disorder 10.0
87 thyroid gland papillary carcinoma 10.0
88 gastritis 10.0
89 mucormycosis 10.0
90 lung disease 10.0
91 herpes simplex 10.0
92 malignant histiocytosis 10.0
93 measles 10.0
94 myeloid leukemia 10.0
95 bacterial pneumonia 10.0
96 ezh2-related overgrowth 10.0
97 acute graft versus host disease 10.0
98 meningococcemia 10.0
99 systemic capillary leak syndrome 10.0
100 systemic onset juvenile idiopathic arthritis 10.0
101 t-cell/histiocyte rich large b cell lymphoma 10.0
102 virus associated hemophagocytic syndrome 10.0
103 rapidly involuting congenital hemangioma 10.0
104 hemophagocytic syndrome associated with an infection 10.0
105 primary hemophagocytic lymphohistiocytosis 10.0
106 acute sensory ataxic neuropathy 10.0
107 secondary pulmonary alveolar proteinosis 10.0
108 histiocytic sarcoma 10.0
109 cytophagic histiocytic panniculitis 10.0
110 overgrowth syndrome 10.0
111 autoinflammatory syndrome 10.0
112 thyroid carcinoma 10.0
113 immune deficiency disease 10.0
114 peripheral t-cell lymphoma 10.0
115 connective tissue disease 10.0
116 polyarteritis nodosa 10.0
117 listeria meningitis 10.0 TNF ADA
118 meningitis 10.0 TNF ADA
119 tuberculous peritonitis 10.0 TNF ADA
120 peritonitis 9.9 TNF ADA
121 tuberculous meningitis 9.9 TNF ADA
122 pleural tuberculosis 9.9 TNF ADA
123 pleural disease 9.9 TNF ADA
124 pleurisy 9.9 TNF ADA
125 pericarditis 9.9 TNF ADA
126 primary bacterial infectious disease 9.9 TNF ADA
127 pulmonary tuberculosis 9.9 TNF ADA
128 omenn syndrome 9.8 TNF ADA
129 pfeiffer syndrome 9.8
130 scleroderma, familial progressive 9.8
131 nasopharyngeal carcinoma 9.8
132 cyanosis, transient neonatal 9.8
133 aspergillosis 9.8
134 inflammatory bowel disease 9.8
135 atrioventricular block 9.8
136 thrombotic thrombocytopenic purpura 9.8
137 strongyloidiasis 9.8
138 cardiac tamponade 9.8
139 nephrotic syndrome 9.8
140 pulmonary sarcoidosis 9.8
141 candidiasis 9.8
142 thrombocytosis 9.8
143 cervicitis 9.8
144 membranoproliferative glomerulonephritis 9.8
145 glomerulonephritis 9.8
146 acute kidney failure 9.8
147 purpura 9.8
148 mixed connective tissue disease 9.8
149 liver cirrhosis 9.8
150 hemolytic anemia 9.8
151 acquired immunodeficiency syndrome 9.8
152 viral encephalitis 9.8
153 end stage renal failure 9.8
154 herpes zoster 9.8
155 acute respiratory distress syndrome 9.8
156 pityriasis lichenoides 9.8
157 viral hemorrhagic fever 9.8
158 mycobacterium tuberculosis 1 9.8 TNF ADA
159 behcet syndrome 9.8 TNF ADA
160 common variable immunodeficiency 9.7 TNF ADA
161 large intestine cancer 9.5 TNF EZH2

Graphical network of the top 20 diseases related to Secondary Hemophagocytic Lymphohistiocytosis:



Diseases related to Secondary Hemophagocytic Lymphohistiocytosis

Symptoms & Phenotypes for Secondary Hemophagocytic Lymphohistiocytosis

MGI Mouse Phenotypes related to Secondary Hemophagocytic Lymphohistiocytosis:

46 (showing 4, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.43 ADA EZH2 TNF
2 endocrine/exocrine gland MP:0005379 9.33 ADA EZH2 TNF
3 muscle MP:0005369 9.13 ADA EZH2 TNF
4 skeleton MP:0005390 8.8 ADA EZH2 TNF

Drugs & Therapeutics for Secondary Hemophagocytic Lymphohistiocytosis

Drugs for Secondary Hemophagocytic Lymphohistiocytosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 62, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
3
Etoposide Approved Phase 3 33419-42-0 36462
4
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
5
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
6
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
7
leucovorin Approved Phase 3 58-05-9 143 6006
8
Mycophenolic acid Approved Phase 3 24280-93-1 446541
9
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
10
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
11
Busulfan Approved, Investigational Phase 3 55-98-1 2478
12
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
13 Hormone Antagonists Phase 3
14 Antiemetics Phase 3
15 Antineoplastic Agents, Phytogenic Phase 3
16 Antifungal Agents Phase 3
17 Gastrointestinal Agents Phase 3
18 Anti-Inflammatory Agents Phase 3
19 Peripheral Nervous System Agents Phase 3
20 glucocorticoids Phase 3
21 Anti-Infective Agents Phase 3
22 Immunosuppressive Agents Phase 3
23 Hormones Phase 3
24 Antineoplastic Agents, Hormonal Phase 3
25 Cyclosporins Phase 3
26 Topoisomerase Inhibitors Phase 3
27 Dermatologic Agents Phase 3
28 Etoposide phosphate Phase 3
29 BB 1101 Phase 3
30 Calcineurin Inhibitors Phase 3
31 Autonomic Agents Phase 3
32 Antirheumatic Agents Phase 3
33 Immunologic Factors Phase 3
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
35 Alkylating Agents Phase 3
36 Folic Acid Antagonists Phase 3
37 Hydrocortisone-17-butyrate Phase 3
38 Anti-Bacterial Agents Phase 3
39 Folate Phase 3
40 Antilymphocyte Serum Phase 3
41 Vitamin B9 Phase 3
42 Antibiotics, Antitubercular Phase 3
43 Vitamin B Complex Phase 3
44 Nucleic Acid Synthesis Inhibitors Phase 3
45 Antitubercular Agents Phase 3
46 Hydrocortisone 17-butyrate 21-propionate Phase 3
47 Hydrocortisone hemisuccinate Phase 3
48 Antimetabolites Phase 3
49 Antimetabolites, Antineoplastic Phase 3
50 Antineoplastic Agents, Alkylating Phase 3
51
Aldesleukin Approved Phase 1, Phase 2 85898-30-2, 110942-02-4
52 Analgesics Phase 1, Phase 2
53 Analgesics, Non-Narcotic Phase 1, Phase 2
54 Anti-HIV Agents Phase 1, Phase 2
55 Antiviral Agents Phase 1, Phase 2
56 Anti-Retroviral Agents Phase 1, Phase 2
57 Interleukin-2 Phase 1, Phase 2
58 HIV Protease Inhibitors Phase 1, Phase 2
59
protease inhibitors Phase 1, Phase 2
60 gamma-Globulins
61 Immunoglobulins, Intravenous
62 Rho(D) Immune Globulin

Interventional clinical trials:

(showing 4, show less)
# Name Status NCT ID Phase Drugs
1 Hemophagocytic Lymphohistiocytosis Unknown status NCT00334672 Phase 3 busulfan;cyclophosphamide;cyclosporine;dexamethasone;etoposide;methotrexate;mycophenolate mofetil;therapeutic hydrocortisone
2 Safety and Efficiency Study of Low-dose IL-2 Treatment in Macrophage Activation Syndrome Unknown status NCT02569463 Phase 1, Phase 2 Interleukin-2
3 Ruxolitinib Combined With Dexamethasone for Pediatric Refractory and Secondary Hemophagocytic Lymphohistiocytosis Recruiting NCT03795909 Phase 1, Phase 2 Ruxolitinib;Dexamethasone
4 Pilot Study of First-line Immunosuppressive Therapy Combined With Etoposide and Allogeneic Hematopoietic Cell Transplantation in Refractory/Reactivated Cases for Hemophagocytic Lymphohistiocytosis (HLH) in Adult Patients Terminated NCT01547143 IST and/or alloHCT

Search NIH Clinical Center for Secondary Hemophagocytic Lymphohistiocytosis

Genetic Tests for Secondary Hemophagocytic Lymphohistiocytosis

Anatomical Context for Secondary Hemophagocytic Lymphohistiocytosis

MalaCards organs/tissues related to Secondary Hemophagocytic Lymphohistiocytosis:

41
T Cells, Liver, Bone, B Cells, Bone Marrow, Myeloid, Monocytes

Publications for Secondary Hemophagocytic Lymphohistiocytosis

Articles related to Secondary Hemophagocytic Lymphohistiocytosis:

(showing 274, show less)
# Title Authors PMID Year
1
Hemophagocytic lymphohistiocytosis: A rare, potentially fatal complication in subcutaneous panniculitis like T cell lymphoma. 38
30289114 2019
2
Etiologies and Clinical Outcomes of Patients With Secondary Hemophagocytic Lymphohistiocytosis at a Tertiary PICU. 38
31149968 2019
3
Human ehrlichiosis at a tertiary-care academic medical center: Clinical associations and outcomes of transplant patients and patients with hemophagocytic lymphohistiocytosis. 38
30913447 2019
4
Dengue infection complicated by hemophagocytic lymphohistiocytosis: Experiences from 180 severe dengue patients. 38
31188423 2019
5
Hemorrhagic fever with renal syndrome with secondary hemophagocytic lymphohistiocytosis in West China: a case report. 38
31164087 2019
6
[Clinical analysis of secondary hemophagocytic lymphohistiocytosis complicated with capillary leak syndrome]. 38
31340624 2019
7
Fludarabine/Melphalan 100 mg/m2 Conditioning Therapy Followed by Allogeneic Hematopoietic Cell Transplantation for Adult Patients with Secondary Hemophagocytic Lymphohistiocytosis. 38
30508593 2019
8
An unusual presentation of purine nucleoside phosphorylase deficiency mimicking systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome. 38
31118063 2019
9
Treatment of refractory secondary hemophagocytic lymphohistiocytosis with umbilical cord mesenchymal stem cells. 38
30961409 2019
10
The inhibitory receptors on NK cells and CTLs are upregulated in adult and adolescent patients with secondary hemophagocytic lymphohistiocytosis. 38
30914280 2019
11
A Novel Mutation c.153 C>A in a Tunisian Girl With Wolman Disease and Unusual Presentation: Hemophagocytic Lymphohistiocytosis. 38
29702543 2019
12
An Elusive Diagnosis: Case Reports of Secondary Hemophagocytic Lymphohistiocytosis and Review of Current Literature. 38
31275772 2019
13
Prevalence and Outcome of Secondary Hemophagocytic Lymphohistiocytosis Among SIRS Patients: Results from a Prospective Cohort Study. 38
31010216 2019
14
The Performance of Diagnostic Criteria for Hemophagocytic Lymphohistiocytosis in Critically Ill Patients. 38
30862243 2019
15
A multicenter study of patients with multisystem Langerhans cell histiocytosis who develop secondary hemophagocytic lymphohistiocytosis. 38
30521100 2019
16
Senescence-accelerated mice (SAMP1/TA-1) treated repeatedly with lipopolysaccharide develop a condition that resembles hemophagocytic lymphohistiocytosis. 38
30819910 2019
17
Treatment outcomes and prognostic factors in adult patients with secondary hemophagocytic lymphohistiocytosis not associated with malignancy. 38
30213834 2019
18
Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice. 38
30674681 2019
19
Secondary hemophagocytic lymphohistiocytosis in pediatric patients: a single center experience and factors that influenced patient prognosis. 38
30821552 2019
20
T-cell lymphoma with secondary hemophagocytic lymphohistiocytosis as a rare cause of acute liver failure T-cell lymphoma as a cause of acute liver failure. 38
30553939 2019
21
Lysosomal Acid Lipase: From Cellular Lipid Handler to Immunometabolic Target. 38
30665623 2019
22
The Immunology of Macrophage Activation Syndrome. 38
30774631 2019
23
A rare case of hepatosplenic gamma-delta T-cell lymphoma and secondary hemophagocytic lymphohistiocytosis. 38
30656034 2019
24
Secondary Hemophagocytic Lymphohistiocytosis: A Challenging Diagnosis in a Patient with Autoimmune Hepatitis. 38
30863647 2019
25
A Catastrophic Presentation of Enteric Fever with Secondary Hemophagocytic Lymphohistiocytosis. 38
31313557 2018
26
Reactive hemophagocytic syndrome in the setting of acute human immunodeficiency virus 1 infection: case report and review of the literature. 38
30114998 2018
27
Early onset lysosomal acid lipase deficiency presenting as secondary hemophagocytic lymphohistiocytosis: Two infants treated with sebelipase alfa. 38
29705274 2018
28
Prognostic Factors and Outcomes in Adults With Secondary Hemophagocytic Lymphohistiocytosis: A Single-center Experience. 38
30037588 2018
29
Fueling the FIRES: Hemophagocytic lymphohistiocytosis in febrile infection-related epilepsy syndrome. 38
30132834 2018
30
Ruxolitinib as first-line treatment in secondary hemophagocytic lymphohistiocytosis: A second experience. 38
29417621 2018
31
Differentiation between incomplete Kawasaki disease and secondary hemophagocytic lymphohistiocytosis following Kawasaki disease using N-terminal pro-brain natriuretic peptide. 38
29853942 2018
32
Childhood Visceral Leishmaniasis: Distinctive Features and Diagnosis of a Re-emerging Disease. An 11-year Experience From a Tertiary Referral Center in Athens, Greece. 38
28938257 2018
33
Hypofibrinogenemia Is Associated With Poor Outcome and Secondary Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome in Pediatric Severe Sepsis. 38
29470247 2018
34
Diagnostic and management of life-threatening Adult-Onset Still Disease: a French nationwide multicenter study and systematic literature review. 38
29642928 2018
35
Fatal meningococcal septicemia without meningeal signs, contribution of the peripheral smear in diagnosis: Report of a case. 38
29676380 2018
36
Allogeneic hematopoietic stem cell transplantation for severe, refractory juvenile idiopathic arthritis. 38
29618462 2018
37
Neonatal Adenovirus Infection Complicated by Hemophagocytic Lymphohistiocytosis Syndrome. 38
29610175 2018
38
A First Report of Secondary Hemophagocytic Lymphohistiocytosis Associated With Papillary Thyroid Carcinoma. 38
29087969 2018
39
Potentially Toxic Chemotherapy in Secondary Hemophagocytic Lymphohistiocytosis Patients That Could Have Been Replaced by Less Immunosuppressive Therapy. 38
28926358 2018
40
A reminder of the place of morphology and the H-score in the diagnosis of hemophagocytic lymphohistiocytosis (HLH). 38
29531733 2018
41
Ruxolitinib as first-line treatment in secondary hemophagocytic lymphohistiocytosis: A single patient experience. 38
29134683 2018
42
Secondary hemophagocytic lymphohistiocytosis in a child with Leptospira infection: A case report. 38
31365212 2018
43
Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis. 38
29515924 2018
44
A Case of Spontaneously Improving Secondary Hemophagocytic Lymphohistiocytosis in an Adult Associated with T-Cell Histiocyte-Rich Large B-Cell Lymphoma. 38
29682376 2018
45
The influence of various therapeutic regimens on early clinical and laboratory response and outcome of children with secondary hemophagocytic lymphohistiocytosis. 38
29379544 2018
46
[Clinical significance of serum calcium and albumin in patients with secondary hemophagocytic lymphohistiocytosis]. 38
29365395 2017
47
Lytic viral replication and immunopathology in a cytomegalovirus-induced mouse model of secondary hemophagocytic lymphohistiocytosis. 38
29258535 2017
48
Successful management of a complicated clinical crisis: A patient with left-sided endocarditis and secondary hemophagocytic lymphohistiocytosis: a rare case report and literature review. 38
29390580 2017
49
Human Bocavirus: Can It Trigger Hemophagocytic Lymphohistiocytosis? 38
28731923 2017
50
A Personalized Diagnostic and Treatment Approach for Macrophage Activation Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in Adults. 38
28871523 2017
51
[Reactive hemophagocytic syndrome]. 38
29064197 2017
52
Infection Associated Secondary Hemophagocytic Lymphohistiocytosis in Sepsis Syndromes - A Tip of an Iceberg. 38
29319247 2017
53
A Novel Case of Pulmonary Nocardiosis with Secondary Hemophagocytic Lymphohistiocytosis. 38
28836562 2017
54
Lemierre's Syndrome as a Trigger for Secondary Hemophagocytic Lymphohistiocytosis. 38
28085751 2017
55
Mycobacterium iranicum bacteremia and hemophagocytic lymphohistiocytosis: a case report. 38
28789664 2017
56
Kawasaki Disease Complicated With Macrophage Activation Syndrome: A Systematic Review. 38
28562511 2017
57
Ruxolitinib for secondary hemophagocytic lymphohistiocytosis: First case report. 38
28834694 2017
58
Secondary Hemophagocytic Lymphohistiocytosis in an Infant with Wolman Disease. 38
27094156 2017
59
High concentration of miR-133 is a useful marker for the diagnosis of lymphoma- associated hemophagocytic syndrome. 38
28869447 2017
60
Reconstitution Inflammatory Syndrome Like Reactive Hemophagocytic Syndrome Associated with Disseminated Histoplasmosis in a HIV Patient. 38
28528522 2017
61
Sepsis due to Streptococcus pneumoniae associated with secondary hemophagocytic lymphohistiocytosis in a splenectomized patient for spherocytosis: A case report. 38
28700505 2017
62
Lymphoid malignancy-associated hemophagocytic lymphohistiocytosis: Search for the hidden source. 38
28648938 2017
63
Recent advances in diagnostic and therapeutic guidelines for primary and secondary hemophagocytic lymphohistiocytosis. 38
28433836 2017
64
Pulmonary Alveolar Proteinosis in Association with Secondary Hemophagocytic Lymphohistiocytosis. 38
28088396 2017
65
Tuberculosis-associated hemophagocytic lymphohistiocytosis with initial presentation of fever of unknown origin in a general hospital: An analysis of 8 clinical cases. 38
28422850 2017
66
Secondary hemophagocytic lymphohistiocytosis in the setting of metastatic renal cell carcinoma: a case report. 38
28249615 2017
67
Secondary Hemophagocytic Lymphohistiocytosis: Do We Really Need Chemotherapeutics for All Patients? 38
28060133 2017
68
Primary and secondary hemophagocytic lymphohistiocytosis have different patterns of T-cell activation, differentiation and repertoire. 38
27925643 2017
69
Use of a mouse model to identify a blood biomarker for IFNγ activity in pediatric secondary hemophagocytic lymphohistiocytosis. 38
27559680 2017
70
Hemophagocytic syndrome masquerading as septic shock: An approach to such dilemma. 38
29318013 2017
71
The Conundrum in the Diagnosis and Management of Atypical Fulminant Measles in a Leukemia Survivor on Maintenance Chemotherapy. 38
27992394 2017
72
Diffuse Large B-Cell Lymphoma with Secondary Hemophagocytic Lymphohistiocytosis Presenting as Acute Liver Failure. 38
28584842 2017
73
Severe dengue due to secondary hemophagocytic lymphohistiocytosis: A case study. 38
28409119 2017
74
Rituximab, etoposide, methylprednisolone, high-dose cytarabine, and cisplatin in the treatment of secondary hemophagocytic lymphohistiocytosis with classical Hodgkin lymphoma: a case report and review of the literature. 38
27998299 2016
75
An Unusual Case of LCHAD Deficiency Presenting With a Clinical Picture of Hemophagocytic Lymphohistiocytosis: Secondary HLH or Coincidence? 38
27769081 2016
76
Human monocytic ehrlichiosis complicated by hemophagocytic lymphohistiocytosis and multi-organ dysfunction syndrome. 38
27575459 2016
77
The Use of Ferritin to Identify Critically Ill Patients With Secondary Hemophagocytic Lymphohistiocytosis. 38
27441901 2016
78
Infection Associated Secondary Hemophagocytic Lymphohistiocytosis in Sepsis Syndromes - A Tip of an Iceberg. 38
27766802 2016
79
Use of Extracorporeal Support in Hemophagocytic Lymphohistiocytosis Secondary to Ehrlichiosis. 38
27633921 2016
80
Hemophagocytic lymphohistiocytosis triggered by Gaucher disease in a preterm neonate. 38
27922757 2016
81
High-Volume Hemofiltration in Critically Ill Patients With Secondary Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome: A Prospective Study in the PICU. 38
27487914 2016
82
Acute HIV infection presenting as hemophagocytic syndrome with an unusual serological and virological response to ART. 38
27793107 2016
83
Toreforant, A Histamine H4 Receptor Antagonist, in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy: Results of 2 Phase II Studies. 38
27422891 2016
84
Secondary hemophagocytic lymphohistiocytosis induced by cholecystitis: A case report and a review of the literature. 38
27423920 2016
85
18F-FDG PET/CT for identifying the potential causes and extent of secondary hemophagocytic lymphohistiocytosis. 38
27537853 2016
86
Liver transplantation for children with acute liver failure associated with secondary hemophagocytic lymphohistiocytosis. 38
27216884 2016
87
Hemophagocytosis in the Acute Phase of Fatal Kawasaki Disease in a 4 Month-Old Girl. 38
27606147 2016
88
Visceral leishmaniasis, hypertriglyceridemia and secondary hemophagocytic lymphohistiocytosis. 38
26872790 2016
89
[Expression of Serum HMGB-1 in Patients with Secondary Hemo-phagocytic Lymphohistiocytosis and Its Clinical Significance]. 38
27342526 2016
90
EZH2 mutation in an adolescent with Weaver syndrome developing acute myeloid leukemia and secondary hemophagocytic lymphohistiocytosis. 38
26762561 2016
91
Cytokine and viral load kinetics in human herpesvirus 8-associated multicentric Castleman's disease complicated by hemophagocytic lymphohistiocytosis. 38
26692197 2016
92
Mouse Cytomegalovirus Infection in BALB/c Mice Resembles Virus-Associated Secondary Hemophagocytic Lymphohistiocytosis and Shows a Pathogenesis Distinct from Primary Hemophagocytic Lymphohistiocytosis. 38
26903481 2016
93
[X-linked lymphoproliferative syndrome type 1 complicated with secondary hemophagocytic lymphohistiocytosis and ileal perforation: case report and literature review]. 38
27055430 2016
94
Viral etiology, clinical and laboratory features of adult hemophagocytic lymphohistiocytosis. 38
26287378 2016
95
Macrophage Activation Syndrome. 38
26400031 2016
96
Successful Treatment of Scrub Typhus-Associated Hemophagocytic Lymphohistiocytosis With Chloramphenicol: Report of 3 Pediatric Cases and Literature Review. 38
26937940 2016
97
IDO1 Deficiency Does Not Affect Disease in Mouse Models of Systemic Juvenile Idiopathic Arthritis and Secondary Hemophagocytic Lymphohistiocytosis. 38
26914138 2016
98
[Successful Treatment of Seasonal Influenza A (H3N2) infection-related Hemophagocytic Lymphocytosis in an Elderly Man]. 38
27032178 2016
99
Successful control of juvenile dermatomyositis-associated macrophage activation syndrome and interstitial pneumonia: distinct kinetics of interleukin-6 and -18 levels. 38
26581448 2015
100
[Pseudotumoral thoracic splenosis in a patient with adult-onset Still disease and reactive hemophagocytic syndrome]. 38
26433835 2015
101
Secondary Hemophagocytic Lymphohistiocytosis in a Patient With Favorable Histology Wilms Tumor. 38
26479988 2015
102
Disseminated mucormycosis-induced perforated intestine in a late presenting AIDS patient with steroid-dependent secondary hemophagocytic lymphohistiocytosis. 38
26544587 2015
103
Secondary hemophagocytic lymphohistiocytosis in children with brucellosis: report of three cases. 38
26517495 2015
104
Secondary Hemophagocytic Lymphohistiocytosis Associated with Epstein-Barr Virus. 38
25708060 2015
105
Elevated serum adenosine deaminase levels in secondary hemophagocytic lymphohistiocytosis. 38
25764155 2015
106
Prognostic Factors and Long-Term Outcome in 52 Turkish Children With Hemophagocytic Lymphohistiocytosis. 38
25901543 2015
107
How We Manage Hyperferritinemic Sepsis-Related Multiple Organ Dysfunction Syndrome/Macrophage Activation Syndrome/Secondary Hemophagocytic Lymphohistiocytosis Histiocytosis. 38
26154908 2015
108
Does Viral Hemorrhagic Fever Represent Reactive Hemophagocytic Syndrome? 38
26136549 2015
109
Epstein-Barr virus viral load in human immunodeficiency virus-positive patients with reactive hemophagocytic syndrome. 38
25746607 2015
110
Validity in the diagnosis of reactive hemophagocytic syndrome: comment on the article by Fardet et Al. 38
25370365 2015
111
[The clinical significance of serum neopterin and adenosine deaminase in patients with secondary hemophagocytic lymphohistiocytosis]. 38
25877146 2015
112
Disseminated Histoplasmosis and Secondary Hemophagocytic Syndrome in a Non-HIV Patient. 38
26347828 2015
113
Clinical features and correct diagnosis of macrophage activation syndrome. 38
26082353 2015
114
Successful treatment of macrophage activation syndrome in a patient with dermatomyositis by combination with immunosuppressive therapy and plasmapheresis. 38
24252010 2015
115
Reactive hemophagocytic syndrome in adult-onset Still disease: clinical features, predictive factors, and prognosis in 21 patients. 38
25634183 2015
116
Progressive Diffuse Osteonecrosis in a Patient with Secondary Hemophagocytic Lymphohistiocytosis. 38
26693376 2015
117
Compartmentalized interleukin-1β in pulmonary secondary hemophagocytic lymphohistiocytosis. 38
25560292 2015
118
Cytomegalovirus infections, kidney transplantation, and secondary hemophagocytic lymphohistiocytosis. 38
25219298 2014
119
Intense and diffuse lung uptake of 99mTc-MDP in a patient with pneumonia associated with secondary hemophagocytic lymphohistiocytosis. 38
24999696 2014
120
Reactive hemophagocytic syndrome in adults: a retrospective analysis of 162 patients. 38
24835040 2014
121
Cytology of secondary hemophagocytic lymphohistiocytosis masquerading as lymphoma in a nonimmunocompromised adult. 38
25745299 2014
122
Macrophage activation syndrome secondary to human monocytic ehrlichiosis. 38
25332563 2014
123
Wolman's disease with secondary hemophagocytic lymphohistiocytosis. 38
24933302 2014
124
Disseminated herpes simplex virus manifesting as pyrexia and cervicitis and leading to reactive hemophagocytic syndrome in pregnancy. 38
24890680 2014
125
Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. 38
24782338 2014
126
Reactive hemophagocytic syndrome in a patient with adult-onset Still disease. 38
25128133 2014
127
Secondary hemophagocytic lymphohistiocytosis (HLH) from a presumed brown recluse spider bite. 38
24737162 2014
128
Therapeutic role of anakinra, an interleukin-1 receptor antagonist, in the management of secondary hemophagocytic lymphohistiocytosis/sepsis/multiple organ dysfunction/macrophage activating syndrome in critically ill children*. 38
24583503 2014
129
Plasma exchange, methylprednisolone, IV immune globulin, and now anakinra support continued PICU equipoise in management of hyperferritinemia-associated sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome/secondary hemophagocytic lymphohistiocytosis syndrome*. 38
24892479 2014
130
A high sIL-2R/ferritin ratio is a useful marker for the diagnosis of lymphoma-associated hemophagocytic syndrome. 38
24705932 2014
131
Clinical implication of F-18 FDG PET/CT in patients with secondary hemophagocytic lymphohistiocytosis. 38
24061788 2014
132
Trichosporon asahii, sepsis, and secondary hemophagocytic lymphohistiocytosis in children with hematologic malignancy. 38
24383917 2014
133
Adult-onset still disease: manifestations, treatment, outcome, and prognostic factors in 57 patients. 38
24646465 2014
134
Hemophagocytic syndrome in patients with acute myeloid leukemia undergoing intensive chemotherapy. 38
24142998 2014
135
Diagnosis and classification of adult Still's disease. 38
24486119 2014
136
Marrow assessment for hemophagocytic lymphohistiocytosis demonstrates poor correlation with disease probability. 38
24343738 2014
137
Adult onset Still's disease with persistent skin lesions complicated by secondary hemophagocytic lymphohistiocytosis. 38
24119099 2014
138
An Unusual Case of Adult-Onset Still's Disease with Hemophagocytic Syndrome, Necrotic Leukoencephalopathy and Disseminated Intravascular Coagulation. 38
24707428 2014
139
Importance of hyperbilirubinemia in differentiation of primary and secondary hemophagocytic lymphohistiocytosis in pediatric cases. 38
25408853 2014
140
Secondary hemophagocytic lymphohistiocytosis possibly induced by interferon beta-1a therapy. 38
24399189 2013
141
Ehrlichiosis presenting with toxic shock-like syndrome and secondary hemophagocytic lymphohistiocytosis. 38
23808094 2013
142
Severe hemorrhagic coagulopathy with hemophagocytic lymphohistiocytosis secondary to Epstein-Barr virus-associated T-cell lymphoproliferative disorder. 38
23439459 2013
143
Human herpesvirus 8-related Castleman disease in the absence of HIV infection. 38
23223599 2013
144
Evaluation of the plasma micro RNA expression levels in secondary hemophagocytic lymphohistiocytosis. 38
24363881 2013
145
Enteric Fever presenting as secondary hemophagocytic lymphohistiocytosis. 38
22415495 2012
146
Hemophagocytic lymphohistiocytosis associated with influenza A (H1N1) infection in a patient with chronic lymphocytic leukemia: an autopsy case report and review of the literature. 38
21724431 2012
147
Hyperferritinemia in the critically ill child with secondary hemophagocytic lymphohistiocytosis/sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome: what is the treatment? 38
22715953 2012
148
Secondary hemophagocytic lymphohistiocytosis in adults: an update on diagnosis and therapy. 38
23271259 2012
149
Secondary hemophagocytic lymphohistiocytosis in zoonoses. A systematic review. 38
23104648 2012
150
Secondary hemophagocytic lymphohistiocytosis: forget me not! 38
22852815 2012
151
[A case of hemophagocytic lymphohistiocytosis syndrome caused by severe tuberculosis and literature review]. 38
23289995 2012
152
Measles and secondary hemophagocytic lymphohistiocytosis. 38
22931858 2012
153
Clinical analysis of macrophage activation syndrome in pediatric patients with autoimmune diseases. 38
22615046 2012
154
The significance of 18F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis. 38
22824539 2012
155
Clinical features of adult patients with secondary hemophagocytic lymphohistiocytosis from causes other than lymphoma: an analysis of treatment outcome and prognostic factors. 38
22147006 2012
156
Reactive hemophagocytic syndrome caused by Rickettsial infection: report of a case. 38
22709789 2012
157
Intravenous immunoglobulin treatment for macrophage activation syndrome complicating chronic granulomatous disease. 38
22119934 2012
158
Reactive hemophagocytic syndrome in adult Korean patients with systemic lupus erythematosus: a case-control study and literature review. 38
22174206 2012
159
Please, do not forget secondary hemophagocytic lymphohistiocytosis in HIV-infected patients. 38
22019569 2011
160
Splenectomy for an adult patient with refractory secondary hemophagocytic lymphohistiocytosis. 38
21873022 2011
161
Fulminant hemophagocytic lymphohistiocytosis induced by pandemic A (H1N1) influenza: a case report. 38
21722406 2011
162
Acquired hemophagocytic lymphohistiocytosis associated with multiple myeloma. 38
20358309 2011
163
Clinical characteristics of hemophagocytic lymphohistiocytosis related to Kawasaki disease. 38
21381871 2011
164
Brucellosis presenting with pancytopenia due to hemophagocytic syndrome. 38
27263945 2011
165
[Clinical analysis of 10 cases of secondary hemophagocytic lymphohistiocytosis treated with HLH-2004 chemotherapy]. 38
21176364 2010
166
Spontaneous resolution of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. 38
20806367 2010
167
Laboratory tests in the diagnosis and follow-up of pediatric rheumatic diseases: an update. 38
19246077 2010
168
A rare hematological manifestation of brucellosis: reactive hemophagocytic syndrome. 38
20457434 2010
169
Novel swine-origin influenza A (H1N1) virus-associated hemophagocytic syndrome--a first case report. 38
20348529 2010
170
[Reactive hemophagocytic syndrome. Is this condition underdiagnosed?]. 38
20172511 2010
171
Soluble components of Histoplasma capsulatum var. capsulatum have hemagglutinin activity and induce syngeneic hemophagocytosis in vitro. 38
19908162 2010
172
Chronic murine typhoid fever is a natural model of secondary hemophagocytic lymphohistiocytosis. 38
20195482 2010
173
Primary and secondary hemophagocytic lymphohistiocytosis: clinical features, pathogenesis and therapy. 38
20383897 2010
174
Reactive hemophagocytic syndrome in adult-onset Still disease: clinical features and long-term outcome: a case-control study of 8 patients. 38
20075703 2010
175
Early diagnostic value of low percentage of glycosylated ferritin in secondary hemophagocytic lymphohistiocytosis. 38
19655220 2009
176
Virus-Associated Hemophagocytic Syndrome related to acute CMV and HBV sexual co-infection: a case report. 38
19640781 2009
177
Pediatric acute lymphoblastic leukemia complicated by secondary hemophagocytic lymphohistiocytosis. 38
19459197 2009
178
An unusual cause of multiple organ dysfunction syndrome in the pediatric intensive care unit: hemophagocytic lymphohistiocytosis. 38
19433941 2009
179
Malignancy-associated hemophagocytic lymphohistiocytosis in pediatric cases: a multicenter study from Turkey. 38
19817262 2009
180
Secondary hemophagocytic lymphohistiocytosis and severe sepsis/ systemic inflammatory response syndrome/multiorgan dysfunction syndrome/macrophage activation syndrome share common intermediate phenotypes on a spectrum of inflammation. 38
19325510 2009
181
Systemic infection of avian influenza A virus H5N1 subtype in humans. 38
19121843 2009
182
Continuous hemodiafiltration in the treatment of reactive hemophagocytic syndrome refractory to medical therapy. 38
19097821 2009
183
Reactive hemophagocytic syndrome. 38
18810357 2008
184
[Diagnostic significance of glycosylated ferritin for patients with secondary hemophagocytic lymphohistiocytosis]. 38
19099648 2008
185
Successful treatment of secondary hemophagocytic lymphohistiocytosis in a patient with disseminated histoplasmosis. 38
18854090 2008
186
Reactive hemophagocytic syndrome treated with extracorporeal membrane oxygenation. 38
19261127 2008
187
[Diagnostic significance of NK cell activity and soluble CD25 level in serum from patients with secondary hemophagocytic lymphohistiocytosis]. 38
18928616 2008
188
Polyarteritis nodosa presenting as pancytopenia: case report and review of the literature. 38
18368407 2008
189
Hemophagocytic syndrome in miliary tuberculosis presenting with noncaseating granulomas in bone marrow and liver. 38
18583221 2008
190
[Destombes Rosaï Dorfman syndrome: description of one case and diagnostic challenges in the tropical setting]. 38
18478777 2008
191
Macrophage activation syndrome in rheumatic disease: what is the role of the antigen presenting cell? 38
18295734 2008
192
Ankylosing spondylitis presenting with macrophage activation syndrome. 38
17235650 2007
193
Ileal perforation and reactive hemophagocytic syndrome in a patient with disseminated histoplasmosis: the role of the real-time polymerase chain reaction in the diagnosis and successful treatment with amphotericin B lipid complex. 38
17141457 2007
194
Fatal reactive hemophagocytosis related to disseminated histoplasmosis with endocarditis: an unusual case diagnosed at autopsy. 38
17330695 2007
195
[Reactive hemophagocytic syndrome in critical care patients. Report of 4 cases]. 38
17408021 2007
196
Secondary hemophagocytic lymphohistiocytosis associated with meningococcemia. 38
17065145 2006
197
Tumor necrosis factor alpha promoter polymorphism associated with increased susceptibility to secondary hemophagocytic lymphohistiocytosis in the Korean population. 38
17166738 2006
198
Interleukin 1 receptor antagonist to treat cytophagic histiocytic panniculitis with secondary hemophagocytic lymphohistiocytosis. 38
17014024 2006
199
[A case of hemophagocytic syndrome with terminal ileal ulcerations]. 38
17047437 2006
200
Reactive hemophagocytic syndrome complicating the treatment of inflammatory bowel disease. 38
16804394 2006
201
A case of rhesus hemolytic disease with hemophagocytosis and severe iron overload due to multiple transfusions. 38
16772878 2006
202
Characteristics and long-term outcome of 15 episodes of systemic lupus erythematosus-associated hemophagocytic syndrome. 38
16721259 2006
203
Reactive hemophagocytic syndrome in a patient with polyarteritis nodosa associated with Epstein-Barr virus reactivation. 38
17073007 2006
204
Influenza pandemics: past, present and future. 38
16440064 2006
205
Reactive hemophagocytic syndrome in a case of systemic lupus erythematosus that was diagnosed by detection of hemophagocytosing macrophages in peripheral blood smears. 38
16767556 2006
206
Secondary hemophagocytic lymphohistiocytosis in Turkish children. 38
16371881 2005
207
[Acute pancreatitis associated with hemophagocytic syndrome in systemic lupus erythematous: a case report]. 38
16435516 2005
208
Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome. 38
15613100 2005
209
The macrophage activation syndrome: a new entity, a potentially fatal complication of rheumatic disorders. 38
16152767 2005
210
Cytomegalovirus-associated hemophagocytic syndrome in a patient with adult onset Still's disease. 38
15789896 2005
211
Hemophagocytic lymphohistiocytosis after chemotherapy for multiple myeloma. 38
15636696 2004
212
A case report of the effect of plasma exchange on reactive hemophagocytic syndrome associated with toxic shock syndrome. 38
15663552 2004
213
Favorable outcome in patients with renal involvement complicating macrophage activation syndrome in systemic onset juvenile rheumatoid arthritis. 38
15468377 2004
214
Secondary hemophagocytic lymphohistiocytosis induced by malaria infection in a child with Langerhans cell histiocytosis. 38
15202166 2004
215
Reactive hemophagocytic syndrome in adult systemic disease: report of twenty-six cases and literature review. 38
14558048 2003
216
Reactive hemophagocytic syndrome associated with disseminated histoplasmosis in a heart transplant recipient. 38
12681429 2003
217
Macrophage activation syndrome following initiation of etanercept in a child with systemic onset juvenile rheumatoid arthritis. 38
12563702 2003
218
[Reactive hemophagocytic syndrome: about one case]. 38
12604390 2003
219
Secondary hemophagocytic lymphohistiocytosis in children: an analysis of etiology and outcome. 38
12403229 2002
220
Thrombotic microangiopathy in hemophagocytic syndrome: a case report. 38
12101856 2002
221
Outbreak of avian influenza A(H5N1) virus infection in Hong Kong in 1997. 38
11938498 2002
222
Reactive hemophagocytic syndrome associated with thrombotic thrombocytopenic purpura during therapeutic plasma exchange. 38
11982958 2002
223
Two cases of reactive hemophagocytic syndrome: a patient with adult-onset Still's disease and a patient with herpes zoster and autoimmune abnormalities. 38
24383780 2001
224
[Panniculitis and macrophage activation syndrome in a child with lupus erythematosus]. 38
11908139 2001
225
Hemophagocytosis in autoimmune disease. 38
11407091 2001
226
Pathology of fatal human infection associated with avian influenza A H5N1 virus. 38
11170064 2001
227
Disseminated histoplasmosis with reactive hemophagocytosis: aspiration cytology findings in two cases. 38
11074651 2000
228
Successful treatment of reactive hemophagocytic syndrome by plasmapheresis and high-dose γ-globulin in a patient with systemic lupus erythematosus. 38
24383641 2000
229
[Intravenously administered gamma-globulins in reactive hemaphagocytic syndrome. Multicenter study to assess their importance, by the immunoglobulins group of experts of CEDIT of the AP-HP]. 38
11139652 2000
230
Reactive hemophagocytic syndrome presenting as a component of multiple organ dysfunction syndrome. 38
11009000 2000
231
Reactive hemophagocytic syndrome as a presenting feature of Hodgkin's disease. 38
10901612 2000
232
Successful treatment of reactive hemophagocytic syndrome with cyclosporin A and intravenous immunoglobulin. 38
10936988 2000
233
[Reactive hemophagocytic syndrome in children]. 38
10761606 2000
234
[Antiphospholipid antibody-associated hemophagocytic syndrome]. 38
10783662 2000
235
Successful bone marrow transplantation in an adult patient with reactive hemophagocytic syndrome associated with myelodysplastic syndrome. 38
10745629 2000
236
Recurrent viral associated hemophagocytic syndrome in a child with Langerhans cell histiocytosis. 38
10598673 1999
237
Aplastic anemia after Mycoplasma pneumoniae infection: a report of two cases. 38
10445893 1999
238
Marked histiocytosis in the portal tract in a patient with reactive hemophagocytic syndrome: An autopsy case. 38
10504532 1999
239
The spectrum of reactive hemophagocytic syndrome in systemic lupus erythematosus. 38
10229419 1999
240
[Polyvalent intravenous immunoglobulins in systemic lupus]. 38
10522315 1999
241
Biomarker and morphological characteristics of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis. 38
9722893 1998
242
Response of Epstein-Barr virus-associated Ki-1+ anaplastic large cell lymphoma to 13-cis retinoic acid and interferon alpha. 38
9650472 1998
243
Photo quiz. I. Reactive hemophagocytic syndrome caused by CMV infection. 38
9636849 1998
244
Infection- and malignancy-associated hemophagocytic syndromes. Secondary hemophagocytic lymphohistiocytosis. 38
9561911 1998
245
Reactive hemophagocytic syndrome associated with Penicillium marneffei infection. 38
9528739 1998
246
[Histiocytic cytophagic panniculitis]. 38
9537003 1997
247
[Hyperferritinemia in Still syndrome in the adult and reactive hemophagocytic syndrome]. 38
9340475 1997
248
Reactive hemophagocytic syndrome and Hodgkin's disease. 38
9136919 1997
249
Hemophagocytic syndrome (HPS) in children and adults. 38
9114593 1997
250
[Macrophage activation syndrome disclosing leukemic transformation of mycosis fungoides]. 38
9740849 1997
251
A study of the possible etiologic association of Epstein-Barr virus with reactive hemophagocytic syndrome in Hong Kong Chinese. 38
8912837 1996
252
Case report: reactive hemophagocytic syndrome associated with disseminated strongyloidiasis. 38
8686729 1996
253
[Human babesiosis in a patient after splenectomy]. 38
8637296 1996
254
[Hemophagocytic syndromes. A series of 23 cases]. 38
8796089 1996
255
Reactive hemophagocytic syndrome: a new presentation of disseminated histoplasmosis in patients with AIDS. 38
8749633 1995
256
[Reactive hemophagocytic syndrome responded to combination chemotherapy with steroid pulse therapy]. 38
8691575 1995
257
Hyperferritinemia in reactive hemophagocytic syndrome report of four adult cases. 38
7604819 1995
258
Aggressive pleomorphic CD2+, CD3-, CD56+ lymphoma with t(5;9)(q31;q34) abnormality. 38
7543014 1995
259
[A case of nephrotic syndrome mimicking membranoproliferative glomerulonephritis (MPGN) and associated with reactive hemophagocytic syndrome after renal death]. 38
7602813 1995
260
[Reactive hemophagocytic syndrome: a probably underestimated cause of thrombocytopenia in intensive acre patients]. 38
8745978 1995
261
[Reactive hemophagocytic syndrome with disseminated intravascular coagulation secondary to acute brucellosis]. 38
7865565 1994
262
Reactive hemophagocytic syndrome simulating acute hepatitis. A case due to hepatic peripheral T-cell lymphoma. 38
7806836 1994
263
Miliary tuberculosis with splenic rupture: a fatal case with hemophagocytic syndrome and possible association with long standing sarcoidosis. 38
7892057 1994
264
Reactive hemophagocytic syndrome: A report of two cases from Kuwait. 38
17586904 1994
265
Reactive hemophagocytic syndrome in childhood--frequent occurrence of atypical mononuclear cells. 38
8070755 1994
266
Large cell lymphoma with initial presentation in the bone marrow. 38
1493910 1992
267
Reactive hemophagocytic syndrome--a clinicopathologic study of 40 patients in an Oriental population. 38
1497014 1992
268
[The reactive hemophagocytic syndrome associated with immunoblastic B-cell lymphoma]. 38
1598430 1992
269
The acute lupus hemophagocytic syndrome. 38
1992881 1991
270
[The reactive hemophagocytic syndrome associated with infection: a study of 3 cases]. 38
2103268 1990
271
[Reactive hemophagocytic syndrome: analysis of a series of 7 cases]. 38
2325464 1990
272
Peripheral T-cell lymphoma presenting as hemophagocytic syndrome. 38
2786835 1989
273
Reactive hemophagocytic syndrome: a study of 7 fatal cases. 38
3588026 1987
274
Reactive hemophagocytic syndrome. 38
4095022 1985

Variations for Secondary Hemophagocytic Lymphohistiocytosis

Expression for Secondary Hemophagocytic Lymphohistiocytosis

Search GEO for disease gene expression data for Secondary Hemophagocytic Lymphohistiocytosis.

Pathways for Secondary Hemophagocytic Lymphohistiocytosis

Pathways related to Secondary Hemophagocytic Lymphohistiocytosis according to GeneCards Suite gene sharing:

(showing 1, show less)
# Super pathways Score Top Affiliating Genes

GO Terms for Secondary Hemophagocytic Lymphohistiocytosis

Cellular components related to Secondary Hemophagocytic Lymphohistiocytosis according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.62 TNF ADA

Biological processes related to Secondary Hemophagocytic Lymphohistiocytosis according to GeneCards Suite gene sharing:

(showing 5, show less)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.32 TNF EZH2
2 regulation of cell proliferation GO:0042127 9.26 TNF EZH2
3 positive regulation of MAP kinase activity GO:0043406 9.16 TNF EZH2
4 regulation of protein phosphorylation GO:0001932 8.96 TNF EZH2
5 embryonic digestive tract development GO:0048566 8.62 TNF ADA

Molecular functions related to Secondary Hemophagocytic Lymphohistiocytosis according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 8.62 TNF EZH2

Sources for Secondary Hemophagocytic Lymphohistiocytosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....