Secondary Hyperparathyroidism

Categories: Bone diseases, Cancer diseases, Endocrine diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Secondary Hyperparathyroidism

MalaCards integrated aliases for Secondary Hyperparathyroidism:

Name: Secondary Hyperparathyroidism 12 38 15 17
Hyperparathyroidism, Secondary 45
Hyperparathyroidism Secondary 56


External Ids:

Disease Ontology 12 DOID:12466
KEGG 38 H01669
MeSH 45 D006962
NCIt 51 C113335
SNOMED-CT 69 91478007
ICD10 34 E21.1
UMLS 74 C0020503

Summaries for Secondary Hyperparathyroidism

MalaCards based summary : Secondary Hyperparathyroidism, also known as hyperparathyroidism, secondary, is related to vitamin d-dependent rickets, type 2a and secondary hyperparathyroidism of renal origin. An important gene associated with Secondary Hyperparathyroidism is CASR (Calcium Sensing Receptor), and among its related pathways/superpathways are Ca, cAMP and Lipid Signaling and Parathyroid hormone synthesis, secretion and action. The drugs Benzocaine and Cinacalcet have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and thyroid, and related phenotypes are cellular and growth/size/body region

Wikipedia : 77 Secondary hyperparathyroidism refers to the excessive secretion of parathyroid hormone (PTH) by the... more...

Related Diseases for Secondary Hyperparathyroidism

Diseases in the Hyperparathyroidism family:

Hyperparathyroidism 1 Hyperparathyroidism 3
Hyperparathyroidism 4 Primary Hyperparathyroidism
Secondary Hyperparathyroidism

Diseases related to Secondary Hyperparathyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 vitamin d-dependent rickets, type 2a 32.1 CYP27B1 VDR
2 secondary hyperparathyroidism of renal origin 31.5 ACP5 ALB BGLAP CALCA CASR CYP27B1
3 primary hyperparathyroidism 30.9 ALB ALPP BGLAP CALCA CASR FGF23
4 end stage renal failure 30.6 ALB EPO PTH
5 calcinosis 30.3 CALCA FGF23 KL
6 hyperparathyroidism 30.3 ACP5 BGLAP CALCA CASR CYP27B1 EPO
7 rickets 30.3 BGLAP CYP27B1 FGF23 PTH VDR
8 osteomalacia 30.2 BGLAP CALCA CASR FGF23 PTH VDR
9 hyperparathyroidism, neonatal severe 30.1 CASR NR1I3
10 idiopathic hypercalciuria 30.0 BGLAP CASR NR1I3 VDR
11 hypophosphatemic rickets, x-linked recessive 30.0 CYP27B1 FGF23 VDR
12 oncogenic osteomalacia 30.0 FGF23 PTH
13 hyperphosphatemia 30.0 CASR FGF23 KL PTH VDR
14 hypophosphatemia 29.9 BGLAP FGF23 PTH
15 calciphylaxis 29.9 ALB CASR EPO FGF23 PTH VDR
16 renal osteodystrophy 29.9 BGLAP CALCA CASR FGF23 PTH TNFRSF11B
17 multiple endocrine neoplasia, type i 29.9 CASR MEN1 PTH
18 parathyroid carcinoma 29.8 CALCA CASR MEN1 PTH
19 nephrolithiasis 29.8 CASR FGF23 PTH VDR
20 familial hypocalciuric hypercalcemia 29.8 CASR PTH SPG7
21 hyperostosis 29.7 FGF23 KL TNFRSF11B
22 kidney disease 29.7 ALB B2M CASR EPO FGF23 PTH
23 parathyroid adenoma 29.6 BGLAP CALCA CASR MEN1 PTH VDR
24 osteitis fibrosa 29.5 B2M BGLAP CALCA CASR PTH
25 bone resorption disease 29.5 ACP5 BGLAP CALCA PTH TNFRSF11B VDR
26 uremia 29.4 ALB B2M CASR EPO PTH TNFRSF11B
27 osteonecrosis 29.4 ACP5 BGLAP PTH TNFRSF11B
28 hypoparathyroidism 29.3 ALPP BGLAP CASR FGF23 PTH SPG7
29 myeloma, multiple 29.0 ALB B2M EPO TNFRSF11B
30 chronic kidney failure 28.8 ALB B2M BGLAP CALCA CASR CYP27B1
31 bone disease 28.3 ACP5 ALPP B2M BGLAP CALCA CASR
32 osteoporosis 28.3 ACP5 ALPP BGLAP CALCA CASR CYP27B1
33 non-renal secondary hyperparathyroidism 12.3
34 vitamin d hydroxylation-deficient rickets, type 1a 11.4
35 osteopetrosis, autosomal recessive 1 11.1
36 axial osteomalacia 10.4 BGLAP PTH
37 hypocalciuric hypercalcemia, familial, type i 10.4 CASR PTH
38 extraskeletal chondroma 10.4 BGLAP PTH
39 hypocalciuric hypercalcemia, familial, type iii 10.4 CASR PTH
40 hypocalciuric hypercalcemia, familial, type ii 10.4 CASR PTH
41 hypoparathyroidism, familial isolated 10.4 CASR PTH
42 hypercalciuria, absorptive, 2 10.4 CASR VDR
43 parathyroid transitional clear cell adenoma 10.3 MEN1 PTH
44 clear cell adenoma 10.3 MEN1 PTH
45 hepatic tuberculosis 10.3 ALB ALPP
46 tracheal calcification 10.3 FGF23 KL
47 hyperparathyroidism 2 with jaw tumors 10.3 CASR MEN1
48 paget disease of bone 5, juvenile-onset 10.3 CALCA TNFRSF11B
49 impaired renal function disease 10.3 BGLAP FGF23 PTH
50 metabolic acidosis 10.3 ALB BGLAP PTH

Graphical network of the top 20 diseases related to Secondary Hyperparathyroidism:

Diseases related to Secondary Hyperparathyroidism

Symptoms & Phenotypes for Secondary Hyperparathyroidism

MGI Mouse Phenotypes related to Secondary Hyperparathyroidism:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.26 ALB B2M CASR CYP27B1 EPO KL
2 growth/size/body region MP:0005378 10.2 B2M CASR CYP27B1 FGF23 KL MEN1
3 cardiovascular system MP:0005385 10.14 B2M EPO FGF23 KL MEN1 PTH
4 homeostasis/metabolism MP:0005376 10.14 ALB B2M CASR CYP27B1 EPO FGF23
5 endocrine/exocrine gland MP:0005379 10.13 ALB B2M CASR CYP27B1 FGF23 KL
6 hematopoietic system MP:0005397 10.09 B2M CASR CYP27B1 EPO FGF23 KL
7 immune system MP:0005387 10.07 B2M CASR CYP27B1 EPO FGF23 KL
8 digestive/alimentary MP:0005381 10.04 ALB B2M CASR FGF23 KL MEN1
9 craniofacial MP:0005382 9.99 CYP27B1 KL MEN1 PTH TNFRSF11B VDR
10 mortality/aging MP:0010768 9.9 ALB B2M CASR EPO FGF23 KL
11 integument MP:0010771 9.87 B2M CASR CYP27B1 EPO FGF23 KL
12 limbs/digits/tail MP:0005371 9.8 CYP27B1 EPO FGF23 KL PTH TNFRSF11B
13 muscle MP:0005369 9.43 ALB CASR EPO KL MEN1 VDR
14 skeleton MP:0005390 9.28 CASR CYP27B1 EPO FGF23 KL PTH

Drugs & Therapeutics for Secondary Hyperparathyroidism

Drugs for Secondary Hyperparathyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 138)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 94-09-7, 1994-09-7 2337
Cinacalcet Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 226256-56-0 156419
tannic acid Approved Phase 4,Phase 3,Phase 2,Not Applicable 1401-55-4
Sevelamer Approved Phase 4,Phase 3,Phase 2,Not Applicable 52757-95-6
Parathyroid hormone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9002-64-6
Calcium acetate Approved, Investigational Phase 4,Phase 3,Not Applicable 62-54-4
Darbepoetin alfa Approved, Investigational Phase 4 11096-26-7, 209810-58-2
Ethanol Approved Phase 4 64-17-5 702
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
Angiotensin II Approved, Investigational Phase 4,Phase 2 68521-88-0, 11128-99-7, 4474-91-3 172198 65143
Racepinephrine Approved Phase 4 329-65-7 838
Calcium Carbonate Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 471-34-1
Alendronate Approved Phase 4,Phase 2,Not Applicable 66376-36-1, 121268-17-5 2088
Atorvastatin Approved Phase 4 134523-00-5 60823
Zoledronic Acid Approved Phase 4,Phase 1 118072-93-8 68740
Pamidronate Approved Phase 4 40391-99-9 4674
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 23925 27284
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-14-6 5280793
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 1406-16-2
Calcium Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7440-70-2 271
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 67-97-0 5280795 6221
Calcitriol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 32222-06-3 134070 5280453
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
Calcifediol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 19356-17-3 5283731 6433735
Alfacalcidol Approved, Nutraceutical Phase 4,Not Applicable 41294-56-8 5282181
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
30 Calciferol Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
31 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Ergocalciferols Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Vitamin D2 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
35 Nutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Vitamins Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
38 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
39 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Calcium, Dietary Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Calcimimetic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 1 alpha-hydroxyergocalciferol Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 retinol Phase 4
47 Retinol palmitate Phase 4
48 Hydroxycholecalciferols Phase 4,Phase 3,Phase 2,Not Applicable
49 Epoetin alfa Phase 4 113427-24-0
50 Hematinics Phase 4

Interventional clinical trials:

(show top 50) (show all 234)
# Name Status NCT ID Phase Drugs
1 Cinacalcet in Management of Secondary Hyperparathyroidism in Haemodialysis Patients Unknown status NCT02338934 Phase 4 Combination Cinacalcet with Vitamin D analogue
2 Intravenous Paricalcitol in Chronic Hemodialysis Patients Unknown status NCT03023748 Phase 4 Intravenous Paricalcitol
3 How Bone is Made in Children Receiving Dialysis Unknown status NCT01799317 Phase 4 Vitamin D2
4 Cholecalciferol Supplementation in Restless Leg Syndrome in Patients With Chronic Kidney Disease Unknown status NCT03063190 Phase 4 Vitamin D;Placebo Oral Tablet
5 Anti-proteinuric Effect of Calcitriol in Non-diabetic Kidney Disease Patients Unknown status NCT01512862 Phase 4 Calcitriol;Placebo
6 Optimizing Treatment Programs for Chronic Kidney Disease-mineral and Bone Disorder and Malnutrition Unknown status NCT02005302 Phase 4 1,25(OH)2 Vitamin D3;Vitamin D2
7 Initial Dosing of Paricalcitol in Secondary Hyperparathyroidism Completed NCT00307840 Phase 4 paricalcitol
8 Parathyroidectomy vs Cinacalcet in the Treatment of Secondary Hyperparathyroidism Post Renal Transplantation Completed NCT01178450 Phase 4 Cinacalcet
9 Efficacy and Safety of Alfacalcidol Compared to Calcitriol for Treatment of Secondary Hyperparathyroidism Completed NCT01115543 Phase 4 alfacalcidol and calcitriol
10 ACHIEVE: Optimizing the Treatment of Secondary Hyperparathyroidism Completed NCT00135304 Phase 4 Sensipar®;Vitamin D
11 Paricalcitol Versus Calcitriol for Efficacy and Safety in Stage 3/4 Chronic Kidney Disease (CKD) With Secondary Hyperparathyroidism (SHPT) Completed NCT00823303 Phase 4 Paricalcitol;Calcitriol
12 Efficacy and Safety of 6 Months Treatment With Paricalcitol Injection or Oral in Patients With Secondary Hyperparathyroidism on Dialysis Completed NCT00537979 Phase 4 Paricalcitol injection;Paricalcitol capsules
13 Efficacy and Safety of Paricalcitol in the Reduction of Secondary Hyperparathyroidism After Kidney Transplantation. Completed NCT01939977 Phase 4 Paricalcitol;Calcifediol
14 START: Sensipar Treatment Algorithm to Reach K/DOQI Targets in Chronic Kidney Disease Subjects With Secondary Hyperparathyroidism Completed NCT00132431 Phase 4 Sensipar
15 Study of Safety and Efficacy of Doxercalciferol in Patients With Chronic Kidney Disease, Stage 3 or 4, and Secondary Hyperparathyroidism Completed NCT00123461 Phase 4 Hectorol (doxercalciferol capsules), 0.5mcg
16 Compare the Efficacy of Cinacalcet vs Traditional Vitamin D for Secondary Hyperparathyroidism (SHPT) Among Subjects Undergoing Hemodialysis Completed NCT01181531 Phase 4 Traditional Vitamin D Therapy;Cinacalcet
17 Effectiveness and Safety of IV Zemplar in Patients on Hemodialysis and With Secondary Hyperparathyroidism Using iPTH/100 as Initial Dose Completed NCT00891813 Phase 4 Zemplar (paricalcitol)
18 20070360 Incident Dialysis Completed NCT00803712 Phase 4 Cinacalcet;Vitamin D
19 Cinacalcet stUdy for Peritoneal Dialysis Patients In Double Arm on the Lowing Effect OF iPTH Level Completed NCT01101113 Phase 4 cinacalcet;control
20 A Phase 4 Study to Determine Dosing of Hectorol® Capsules When Converting From Zemplar® Injection Completed NCT00463021 Phase 4 Hectorol (doxercalciferol capsules);Zemplar (paricalcitol injection)
21 Cincalcet and Vascular Arterial Stiffness Among Peritoneal Dialysis Patients With Secondary Hyperparathyroidism Completed NCT01143987 Phase 4 Cinacalcet
22 A Phase 4, Conversion Study of Hectorol® Injection to Hectorol® Capsules in Stage 5 CKD Patients on Dialysis Completed NCT00418600 Phase 4 Hectorol® (doxercalciferol capsules);doxercalciferol capsules, Hectorol®;doxercalciferol capsules, Hectorol® capsules
23 Vitamin D Deficiency in Chronic Kidney Disease (CKD) Patients Completed NCT00958451 Phase 4 Paricalcitol;Ergocalciferol
24 Study to Evaluate the Effects of Zemplar Injection and Calcijex on Intestinal Absorption of Calcium Completed NCT00073710 Phase 4 Zemplar;Calcijex
25 Evaluation of the Effectiveness of Paricalcitol Versus Cinacalcet With Low-Dose Vitamin D Completed NCT00977080 Phase 4 Paricalcitol;Cinacalcet
26 Treatment Adhesion in Dialysis Patients Treated With Cinacalcet Completed NCT01573520 Phase 4
27 A Study of Cinacalcet to Improve Achievement of National Kidney Foundation Kidney Disease Outcomes Quality Initiative (K/DOQI) Targets in Patients With End Stage Renal Disease (ESRD) Completed NCT00431496 Phase 4 Cinacalcet
28 A Pilot Clinical Study Evaluating the Effect of Parathyroid Hormone (PTH) Lowering On Erythropoietin Consumption in Calcitriol-Resistant Patients Completed NCT01506947 Phase 4 Paricalcitol;Darbepoetin alfa
29 A Phase 4 Pharmacokinetic Study of Hectorol Injection and Zemplar Injection in CKD Subjects on Hemodialysis Completed NCT00454350 Phase 4 Hectorol (doxercalciferol injection);Zemplar (Paricalcitol injection)
30 Trial to Optimize Mineral Outcomes in Dialysis Patients Completed NCT01100723 Phase 4
31 Characterization of Hyperparathyroidism and Vitamin D Deficiency in Obesity Completed NCT00288873 Phase 4 Ergocalciferol;Cholecalciferol
32 Vitamin D and Coronary Calcification Study Completed NCT00752102 Phase 4 Calcitriol (Rocaltrol®);Paricalcitol
33 A Research Study for Patients With End-Stage Renal Disease (ESRD) Completed NCT00110890 Phase 4 cinacalcet
34 Safety and Effectiveness of Zemplar Injection in Decreasing iPTH Levels in Pediatric ESRD Subjects on Hemodialysis Completed NCT00053547 Phase 4 paricalcitol injection
35 Paricalcitol Effect on Anemia in CKD Completed NCT01768351 Phase 4 Paricalcitol;Calcitriol
36 A Study of Zemplar® Injection and Hectorol® Injection on Intestinal Absorption of Calcium in Chronic Kidney Disease Completed NCT00257920 Phase 4 Zemplar® injection;Hectorol® injection
37 Physiologic Interactions Between the Adrenal- and the Parathyroid Glands Completed NCT02572960 Phase 4 Valsartan;Placebo Valsartan
38 Vitamin D Status in Males in Jerusalem Area and Its Correlation to Parathyroid Hormone (PTH) Level and Bone Mineral Density Completed NCT01025128 Phase 4 25 OH vitamin D
39 Effect of Phosphate Binders on FGF-23 With Concurrent Calcitriol Completed NCT01748396 Phase 4 Calcitriol;Calcium Carbonate
40 Calcitriol in the Treatment of Immunoglobulin A (IgA) Nephropathy Completed NCT00319761 Phase 4 Calcitriol
41 Cholecalciferol Supplementation Effect on Parathyroid Hormone in Hemodialysis Patients Completed NCT03648528 Phase 4 cholecalciferol;placebo
42 Efficacy of Usual Vitamin D Supplementation and Its Impact on Children and Adolescents Calciuria. Completed NCT02238418 Phase 4 Cholecalciferol vial (100 000 UI)
43 Efficacy of Vitamin D2 to Treat Chronic Kidney Disease Mineral and Bone Disorder Completed NCT01633853 Phase 4 Vitamin D2;1,25(OH)2 Vit D3
44 Study of the Effect of Alendronate on Vascular Calcification and Arterial Stiffness in Chronic Kidney Disease Completed NCT00395382 Phase 4 Alendronate;Placebo
45 How Vitamin D Analogues Affect Endothelial Cells in Patients on Dialysis Completed NCT00528788 Phase 4 doxercalciferol
46 ADVANCE: Study to Evaluate Cinacalcet Plus Low Dose Vitamin D on Vascular Calcification in Subjects With Chronic Kidney Disease Receiving Hemodialysis Completed NCT00379899 Phase 4 cinacalcet
47 A Study to Evaluate Alendronate Sodium /Vitamin D3 Combination Tablets(FOSAMAX PLUS) Versus Calcitriol in the Treatment of Osteoporosis in Postmenopausal Women in China (MK-0217A-264) Completed NCT01350934 Phase 4 alendronate 70-mg/vitamin D3 5600 IU combination tablet (Fosamax Plus);Calcitriol
48 The Study of Efficacy and Safety of REGPARA Drug in Dialysis Patients Have High Blood Levels of Parathyroid Completed NCT02056730 Phase 4 calcium sensing receptor agonist
49 CARE-2 (Calcium Acetate [PhosLo®]/Sevelamer[Renagel®] Evaluation Study 2) for Heart Calcification in Dialysis Patients Completed NCT00211939 Phase 4 calcium acetate;sevelamer;atorvastatin
50 Zoledronic Acid to Prevent Bone Loss After Kidney Transplantation Completed NCT01675089 Phase 4 Zoledronic acid

Search NIH Clinical Center for Secondary Hyperparathyroidism

Cochrane evidence based reviews: hyperparathyroidism, secondary

Genetic Tests for Secondary Hyperparathyroidism

Anatomical Context for Secondary Hyperparathyroidism

MalaCards organs/tissues related to Secondary Hyperparathyroidism:

Kidney, Bone, Thyroid, Endothelial, Prostate, Skin, Brain

Publications for Secondary Hyperparathyroidism

Articles related to Secondary Hyperparathyroidism:

(show top 50) (show all 1878)
# Title Authors Year
Subtotal Parathyroidectomy vs Total Parathyroidectomy with Autotransplantation for Secondary Hyperparathyroidism in Dialysis Patients: Short- and Long-Term Outcomes. ( 30776511 )
Avascular osteonecrosis in kidney transplant recipients: Risk factors in a recent cohort study and evaluation of the role of secondary hyperparathyroidism. ( 30794689 )
Three Therapeutic Strategies: Cinacalcet, Paricalcitol or Both in Secondary Hyperparathyroidism Treatment in Hemodialysed Patients During 1-Year Observational Study-A Comparison. ( 30804890 )
Microwave ablation vs. parathyroidectomy for secondary hyperparathyroidism in maintenance hemodialysis patients. ( 30815995 )
Simultaneous spontaneous bilateral quadriceps tendon rupture with secondary hyperparathyroidism in a patient receiving hemodialysis: A case report. ( 30855501 )
One-year safety and efficacy of intravenous etelcalcetide in patients on hemodialysis with secondary hyperparathyroidism. ( 30859218 )
An integrated analysis of safety and tolerability of etelcalcetide in patients receiving hemodialysis with secondary hyperparathyroidism. ( 30875390 )
Aiming Too Low: Reevaluation of Target Concentrations of Serum 25-Hydroxyvitamin D in Secondary Hyperparathyroidism. ( 30879016 )
Influence of Pre-renal Transplant Secondary Hyperparathyroidism on Later Evolution After Transplantation. ( 30879538 )
Analysis of the role of thyroidectomy and thymectomy in the surgical treatment of secondary hyperparathyroidism. ( 30472135 )
A randomized, double-blind, placebo-controlled study to assess the efficacy and safety of cinacalcet in pediatric patients with chronic kidney disease and secondary hyperparathyroidism receiving dialysis. ( 30506144 )
A Bayesian network analysis on comparative efficacy of treatment strategies for dialysis patients with secondary hyperparathyroidism. ( 30651833 )
Medication Prescription Patterns for Secondary Hyperparathyroidism: More Questions than Answers. ( 30665921 )
US-guided microwave ablation for secondary hyperparathyroidism in patients after renal transplantation: a pilot study. ( 30676132 )
Peritoneal dialysis can alleviate the clinical course of hungry bone syndrome after parathyroidectomy in dialysis patients with secondary hyperparathyroidism. ( 30689179 )
Improved Control of Secondary Hyperparathyroidism in Hemodialysis Patients Switching from Oral Cinacalcet to Intravenous Etelcalcetide, Especially in Nonadherent Patients. ( 30699421 )
Effects of Long-Term Cinacalcet Administration on Parathyroid Gland in Hemodialysis Patients with Secondary Hyperparathyroidism. ( 30712039 )
Effects of parathyroidectomy on the biology of bone tissue in patients with chronic kidney disease and secondary hyperparathyroidism. ( 30738215 )
Bridging adults and paediatrics with secondary hyperparathyroidism receiving haemodialysis: a pharmacokinetic-pharmacodynamic analysis of cinacalcet. ( 30756425 )
Calcitriol accelerates vascular calcification irrespective of vitamin K status in a rat model of CKD with hyperphosphatemia and secondary hyperparathyroidism. ( 29903718 )
Cinacalcet versus Placebo for secondary hyperparathyroidism in chronic kidney disease patients: a meta-analysis of randomized controlled trials and trial sequential analysis. ( 29449603 )
Treatment Based on Cinacalcet Reduces Oxidative Stress in Hemodialysis Patients with Secondary Hyperparathyroidism. ( 29879701 )
Old and new calcimimetics for treatment of secondary hyperparathyroidism: impact on biochemical and relevant clinical outcomes. ( 29423207 )
Influence of Parathyroidectomy on Bone Metabolism and Bone Pain in Patients with Secondary Hyperparathyroidism. ( 29393259 )
Role of etelcalcetide in the management of secondary hyperparathyroidism in hemodialysis patients: a review on current data and place in therapy. ( 29910605 )
Cholecalciferol Additively Reduces Serum Parathyroid Hormone Levels in Severe Secondary Hyperparathyroidism Treated with Calcitriol and Cinacalcet among Hemodialysis Patients. ( 29439405 )
Periosteal chondroma of the cuboid with secondary aneurysmal bone cyst in a setting of secondary hyperparathyroidism. ( 29413778 )
Case report: Electron microscopic evaluation of bone from a patient treated with cinacalcet hydrochloride, maxacalcitol, and alfacalcidol for hyperparathyroid bone disease with secondary hyperparathyroidism. ( 29492624 )
Changes in bone mineral density after total parathyroidectomy without autotransplantation in the end-stage renal disease patients with secondary hyperparathyroidism. ( 29907149 )
Dystrophic Calcifications in the Breast from Secondary Hyperparathyroidism. ( 29950967 )
Unusually Large Brown tumor of Mandible in a Case of Secondary Hyperparathyroidism Mimicking Cherubism. ( 29643674 )
Cortical and trabecular bone are equally affected in rats with renal failure and secondary hyperparathyroidism. ( 29394885 )
Severe secondary hyperparathyroidism in patients on haemodialysis is associated with a high initial serum parathyroid hormone and beta-CrossLaps level: Results from an incident cohort. ( 29912988 )
Phase 2b study of evocalcet (KHK7580), a novel calcimimetic, in Japanese patients with secondary hyperparathyroidism undergoing hemodialysis: A randomized, double-blind, placebo-controlled, dose-finding study. ( 30379826 )
Secondary hyperparathyroidism: Pathogenesis and latest treatment. ( 30411503 )
Total versus subtotal parathyroidectomy for secondary hyperparathyroidism. ( 30413319 )
Redox State of Human Serum Albumin and Inflammatory Biomarkers in Hemodialysis Patients with Secondary Hyperparathyroidism During Oral Calcitriol Supplementation for Vitamin D. ( 30450134 )
Parathyroidectomy decreases serum intact parathyroid hormone and calcium levels and prolongs overall survival in elderly hemodialysis patients with severe secondary hyperparathyroidism. ( 30485538 )
Corrigendum to "Quality of life after surgery in secondary hyperparathyroidism comparing subtotal parathyroidectomy to total parathyroidectomy with immediate parathyroid autograft - a prospective randomized trial" [Surgery 164 (2018) 978-985]. ( 30501922 )
The Emerging Role of Nutritional Vitamin D in Secondary Hyperparathyroidism in CKD. ( 30513912 )
Secondary Hyperparathyroidism in Patients with Biliopancreatic Diversion After 10 Years of Follow-up, and Relationship with Vitamin D and Serum Calcium. ( 30523538 )
Effect of Oral Alfacalcidol on Clinical Outcomes in Patients Without Secondary Hyperparathyroidism Receiving Maintenance Hemodialysis: The J-DAVID Randomized Clinical Trial. ( 30535217 )
Recurrent secondary hyperparathyroidism following parathyroidectomy with autotransplantation. Parathyroid scintigraphy with 99mTc-MIBI SPECT/CT. ( 30579915 )
Changes in serum FGF23 and Klotho levels and calcification scores of the abdominal aorta after parathyroidectomy for secondary hyperparathyroidism. ( 30594298 )
Secondary hyperparathyroidism among Nigerians with chronic kidney disease. ( 30602972 )
Reproductive disorders, osteoporosis and secondary hyperparathyroidism with celiac disease. ( 30701802 )
Absent 99mTc-MIBI Uptake in the Thyroid Gland during Early Phase of Parathyroid Scintigraphy in Patients with Primary and Secondary Hyperparathyroidism. ( 29875850 )
Sagliker Syndrome in a Patient with Secondary Hyperparathyroidism and Chronic Renal Insufficiency: A Case Report. ( 29998151 )
Treatment of secondary hyperparathyroidism: How do cinacalcet and etelcalcetide differ? ( 30009474 )
Etelcalcetide (Parsabiv) for Secondary Hyperparathyroidism in Adults With Chronic Kidney Disease on Hemodialysis. ( 30013296 )

Variations for Secondary Hyperparathyroidism

Expression for Secondary Hyperparathyroidism

Search GEO for disease gene expression data for Secondary Hyperparathyroidism.

Pathways for Secondary Hyperparathyroidism

GO Terms for Secondary Hyperparathyroidism

Cellular components related to Secondary Hyperparathyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 ALB B2M BGLAP CALCA EPO FGF23
2 endoplasmic reticulum lumen GO:0005788 9.35 ALB B2M BGLAP FGF23 MEN1
3 extracellular space GO:0005615 9.28 ALB B2M BGLAP CALCA EPO FGF23

Biological processes related to Secondary Hyperparathyroidism according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.92 B2M BGLAP PTH TNFRSF11B
2 aging GO:0007568 9.86 BGLAP CALCA EPO KL
3 regulation of signaling receptor activity GO:0010469 9.85 CALCA EPO FGF23 KL PTH TNFRSF11B
4 skeletal system development GO:0001501 9.83 BGLAP PTH TNFRSF11B VDR
5 calcium ion transport GO:0006816 9.81 CYP27B1 PTH VDR
6 cellular calcium ion homeostasis GO:0006874 9.78 CALCA CASR PTH VDR
7 ossification GO:0001503 9.76 ACP5 BGLAP CASR
8 cellular protein metabolic process GO:0044267 9.72 ALB B2M CALCA FGF23 MEN1
9 bone mineralization GO:0030282 9.69 BGLAP CYP27B1 PTH
10 bone resorption GO:0045453 9.63 ACP5 PTH
11 vasodilation GO:0042311 9.63 CALCA CASR
12 decidualization GO:0046697 9.63 CYP27B1 MEN1 VDR
13 osteoblast development GO:0002076 9.62 BGLAP MEN1
14 positive regulation of keratinocyte differentiation GO:0045618 9.61 CYP27B1 VDR
15 negative regulation of bone resorption GO:0045779 9.61 CALCA TNFRSF11B
16 regulation of bone mineralization GO:0030500 9.61 BGLAP CYP27B1 FGF23
17 response to inorganic substance GO:0010035 9.6 BGLAP TNFRSF11B
18 response to magnesium ion GO:0032026 9.59 FGF23 TNFRSF11B
19 phosphate ion homeostasis GO:0055062 9.58 FGF23 PTH
20 response to vitamin D GO:0033280 9.58 BGLAP CYP27B1 PTH
21 response to fibroblast growth factor GO:0071774 9.57 CASR PTH
22 response to estrogen GO:0043627 9.56 BGLAP CYP27B1 EPO TNFRSF11B
23 negative regulation of calcium ion transport into cytosol GO:0010523 9.55 CALCA EPO
24 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 9.54 FGF23 KL
25 vitamin D catabolic process GO:0042369 9.49 CYP27B1 FGF23
26 vitamin D metabolic process GO:0042359 9.33 CYP27B1 FGF23 VDR
27 cellular response to vitamin D GO:0071305 9.13 BGLAP CASR FGF23
28 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 8.8 CYP27B1 FGF23 VDR

Molecular functions related to Secondary Hyperparathyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vitamin D binding GO:0005499 8.96 KL VDR
2 hormone activity GO:0005179 8.92 CALCA EPO KL PTH

Sources for Secondary Hyperparathyroidism

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
33 HPO
34 ICD10
35 ICD10 via Orphanet
39 LifeMap
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
56 Novoseek
59 OMIM via Orphanet
63 PubMed
71 SNOMED-CT via Orphanet
73 Tocris
75 UMLS via Orphanet
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