MCID: SCN001
MIFTS: 52

Secondary Hyperparathyroidism of Renal Origin

Categories: Endocrine diseases, Nephrological diseases

Aliases & Classifications for Secondary Hyperparathyroidism of Renal Origin

MalaCards integrated aliases for Secondary Hyperparathyroidism of Renal Origin:

Name: Secondary Hyperparathyroidism of Renal Origin 12
Secondary Hyperparathyroidism 12 37 15
Hyperparathyroidism, Secondary 44 73
Hyperparathyroidism Due to Renal Insufficiency 12
Hyperparathyroidism Secondary 55

Classifications:



External Ids:

Disease Ontology 12 DOID:12465 DOID:12466
ICD10 33 N25.81 E21.1
ICD9CM 35 588.81
MeSH 44 D006962
NCIt 50 C113335
KEGG 37 H01669

Summaries for Secondary Hyperparathyroidism of Renal Origin

MalaCards based summary : Secondary Hyperparathyroidism of Renal Origin, also known as secondary hyperparathyroidism, is related to vitamin d-dependent rickets, type 2a and primary hyperparathyroidism. An important gene associated with Secondary Hyperparathyroidism of Renal Origin is PTH (Parathyroid Hormone), and among its related pathways/superpathways are Ca, cAMP and Lipid Signaling and Parathyroid hormone synthesis, secretion and action. Affiliated tissues include kidney, bone and thyroid, and related phenotypes are hematopoietic system and endocrine/exocrine gland

Related Diseases for Secondary Hyperparathyroidism of Renal Origin

Diseases related to Secondary Hyperparathyroidism of Renal Origin via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 vitamin d-dependent rickets, type 2a 31.9 CYP27B1 VDR
2 primary hyperparathyroidism 31.4 ALB BGLAP CALCA CASR FGF23 PTH
3 kidney disease 30.1 ALB CASR EPO FGF23 PTH TNFRSF11B
4 hyperphosphatemia 30.1 CASR FGF23 PTH VDR
5 end stage renal failure 30.1 ALB EPO PTH
6 pseudohypoparathyroidism 30.1 BGLAP PTH
7 idiopathic hypercalciuria 29.9 BGLAP CASR VDR
8 osteitis fibrosa 29.9 BGLAP CALCA CASR PTH
9 familial hypocalciuric hypercalcemia 29.9 CASR PTH
10 oncogenic osteomalacia 29.9 FGF23 PTH
11 hypophosphatemic rickets, x-linked recessive 29.8 CYP27B1 FGF23 VDR
12 parathyroid carcinoma 29.8 CALCA CASR PTH
13 hypoparathyroidism 29.7 BGLAP CASR FGF23 PTH
14 rickets 29.7 BGLAP CYP27B1 FGF23 PTH VDR
15 pseudohypoparathyroidism, type ib 29.7 BGLAP PTH
16 hypophosphatemia 29.7 BGLAP FGF23 PTH
17 uremia 29.7 ALB CASR EPO PTH TNFRSF11B VDR
18 calciphylaxis 29.6 ALB CASR EPO FGF23 PTH VDR
19 osteomalacia 29.6 BGLAP CALCA CASR FGF23 PTH VDR
20 renal osteodystrophy 29.6 BGLAP CALCA CASR FGF23 PTH TNFRSF11B
21 parathyroid adenoma 29.6 BGLAP CALCA CASR PTH VDR
22 nephrolithiasis 29.5 CASR FGF23 PTH VDR
23 bone resorption disease 29.3 ACP5 BGLAP CALCA PTH TNFRSF11B VDR
24 chronic kidney failure 29.3 ALB BGLAP CALCA CASR CYP27B1 EPO
25 myeloma, multiple 29.2 ALB EPO TNFRSF11B
26 bone disease 28.9 ACP5 BGLAP CALCA CASR FGF23 PTH
27 osteoporosis 28.5 ACP5 ALB BGLAP CALCA CASR CYP27B1
28 hyperparathyroidism 28.0 ACP5 BGLAP CALCA CASR CYP27B1 EPO
29 non-renal secondary hyperparathyroidism 12.3
30 vitamin d hydroxylation-deficient rickets, type 1a 11.4
31 osteopetrosis, autosomal recessive 1 11.1
32 hypocalciuric hypercalcemia, familial, type i 10.2 CASR PTH
33 hypocalciuric hypercalcemia, familial, type iii 10.2 CASR PTH
34 hypocalciuric hypercalcemia, familial, type ii 10.2 CASR PTH
35 hypoparathyroidism, familial isolated 10.2 CASR PTH
36 familial isolated hyperparathyroidism 10.2 CASR PTH
37 hypercalciuria, absorptive, 2 10.2 CASR VDR
38 axial osteomalacia 10.2 BGLAP PTH
39 extraskeletal chondroma 10.2 BGLAP PTH
40 hypophosphatemic rickets, x-linked dominant 10.2 FGF23 PTH
41 pulmonary alveolar microlithiasis 10.2 FGF23 PTH
42 spondylosis 10.2 PTH VDR
43 thyroid crisis 10.2 ALB PTH
44 xanthinuria, type i 10.2 CASR VDR
45 metal metabolism disorder 10.2 CASR PTH
46 sagliker syndrome 10.1
47 multicentric carpotarsal osteolysis syndrome 10.1 BGLAP TNFRSF11B
48 nephrolithiasis, calcium oxalate 10.1 CASR VDR
49 impaired renal function disease 10.1 BGLAP FGF23 PTH
50 chondrocalcinosis 10.1 CASR TNFRSF11B

Graphical network of the top 20 diseases related to Secondary Hyperparathyroidism of Renal Origin:



Diseases related to Secondary Hyperparathyroidism of Renal Origin

Symptoms & Phenotypes for Secondary Hyperparathyroidism of Renal Origin

MGI Mouse Phenotypes related to Secondary Hyperparathyroidism of Renal Origin:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.87 CASR CYP27B1 EPO FGF23 PTH TNFRSF11B
2 endocrine/exocrine gland MP:0005379 9.85 ALB CASR CYP27B1 FGF23 PTH VDR
3 immune system MP:0005387 9.8 CASR CYP27B1 EPO FGF23 PTH TNFRSF11B
4 limbs/digits/tail MP:0005371 9.63 CYP27B1 EPO FGF23 PTH TNFRSF11B VDR
5 renal/urinary system MP:0005367 9.35 ALB CASR CYP27B1 FGF23 VDR
6 skeleton MP:0005390 9.17 CASR CYP27B1 EPO FGF23 PTH TNFRSF11B

Drugs & Therapeutics for Secondary Hyperparathyroidism of Renal Origin

Search Clinical Trials , NIH Clinical Center for Secondary Hyperparathyroidism of Renal Origin

Cochrane evidence based reviews: hyperparathyroidism, secondary

Genetic Tests for Secondary Hyperparathyroidism of Renal Origin

Anatomical Context for Secondary Hyperparathyroidism of Renal Origin

MalaCards organs/tissues related to Secondary Hyperparathyroidism of Renal Origin:

41
Kidney, Bone, Thyroid, Liver, Endothelial, Heart, Spinal Cord

Publications for Secondary Hyperparathyroidism of Renal Origin

Articles related to Secondary Hyperparathyroidism of Renal Origin:

(show top 50) (show all 1139)
# Title Authors Year
1
Analysis of the role of thyroidectomy and thymectomy in the surgical treatment of secondary hyperparathyroidism. ( 30472135 )
2019
2
Calcitriol accelerates vascular calcification irrespective of vitamin K status in a rat model of CKD with hyperphosphatemia and secondary hyperparathyroidism. ( 29903718 )
2018
3
Cinacalcet versus Placebo for secondary hyperparathyroidism in chronic kidney disease patients: a meta-analysis of randomized controlled trials and trial sequential analysis. ( 29449603 )
2018
4
Treatment Based on Cinacalcet Reduces Oxidative Stress in Hemodialysis Patients with Secondary Hyperparathyroidism. ( 29879701 )
2018
5
Old and new calcimimetics for treatment of secondary hyperparathyroidism: impact on biochemical and relevant clinical outcomes. ( 29423207 )
2018
6
Influence of Parathyroidectomy on Bone Metabolism and Bone Pain in Patients with Secondary Hyperparathyroidism. ( 29393259 )
2018
7
Role of etelcalcetide in the management of secondary hyperparathyroidism in hemodialysis patients: a review on current data and place in therapy. ( 29910605 )
2018
8
Cholecalciferol Additively Reduces Serum Parathyroid Hormone Levels in Severe Secondary Hyperparathyroidism Treated with Calcitriol and Cinacalcet among Hemodialysis Patients. ( 29439405 )
2018
9
Periosteal chondroma of the cuboid with secondary aneurysmal bone cyst in a setting of secondary hyperparathyroidism. ( 29413778 )
2018
10
Case report: Electron microscopic evaluation of bone from a patient treated with cinacalcet hydrochloride, maxacalcitol, and alfacalcidol for hyperparathyroid bone disease with secondary hyperparathyroidism. ( 29492624 )
2018
11
Changes in bone mineral density after total parathyroidectomy without autotransplantation in the end-stage renal disease patients with secondary hyperparathyroidism. ( 29907149 )
2018
12
Dystrophic Calcifications in the Breast from Secondary Hyperparathyroidism. ( 29950967 )
2018
13
Unusually Large Brown tumor of Mandible in a Case of Secondary Hyperparathyroidism Mimicking Cherubism. ( 29643674 )
2018
14
Cortical and trabecular bone are equally affected in rats with renal failure and secondary hyperparathyroidism. ( 29394885 )
2018
15
Sixty-Two-Year-Old Male Suffering From Uremic Leontiasis Ossea Caused by Severe Secondary Hyperparathyroidism. ( 30283905 )
2018
16
A novel device in parathyroid autotransplantation for 6 patients with secondary hyperparathyroidism - Case series. ( 30294428 )
2018
17
Craniofacial Brown Tumor in Patients with Secondary Hyperparathyroidism to Chronic Renal Failure: Report of Two Cases in Cipto Mangunkusumo Hospital. ( 30298112 )
2018
18
Mediastinal Remnant Thymic Tissue Misdiagnosed as Ectopic Parathyroid Hyperplasia in Secondary Hyperparathyroidism. ( 30325824 )
2018
19
Conservative three-quarter versus subtotal seven-eighths parathyroidectomy in secondary hyperparathyroidism. ( 30327179 )
2018
20
Comparison of Paricalcitol and Calcitriol in Dialysis Patients With Secondary Hyperparathyroidism: A Meta-Analysis of Randomized Controlled Studies. ( 30328270 )
2018
21
Pharmacology of Parsabiv® (etelcalcetide, ONO-5163/AMG 416), a novel allosteric modulator of the calcium-sensing receptor, for secondary hyperparathyroidism in hemodialysis patients. ( 30342948 )
2018
22
Phase 2b study of evocalcet (KHK7580), a novel calcimimetic, in Japanese patients with secondary hyperparathyroidism undergoing hemodialysis: A randomized, double-blind, placebo-controlled, dose-finding study. ( 30379826 )
2018
23
Secondary hyperparathyroidism: Pathogenesis and latest treatment. ( 30411503 )
2018
24
Total versus subtotal parathyroidectomy for secondary hyperparathyroidism. ( 30413319 )
2018
25
Redox State of Human Serum Albumin and Inflammatory Biomarkers in Hemodialysis Patients with Secondary Hyperparathyroidism During Oral Calcitriol Supplementation for Vitamin D. ( 30450134 )
2018
26
Parathyroidectomy decreases serum intact parathyroid hormone and calcium levels and prolongs overall survival in elderly hemodialysis patients with severe secondary hyperparathyroidism. ( 30485538 )
2018
27
Corrigendum to "Quality of life after surgery in secondary hyperparathyroidism comparing subtotal parathyroidectomy to total parathyroidectomy with immediate parathyroid autograft - a prospective randomized trial" [Surgery 164 (2018) 978-985]. ( 30501922 )
2018
28
A randomized, double-blind, placebo-controlled study to assess the efficacy and safety of cinacalcet in pediatric patients with chronic kidney disease and secondary hyperparathyroidism receiving dialysis. ( 30506144 )
2018
29
The Emerging Role of Nutritional Vitamin D in Secondary Hyperparathyroidism in CKD. ( 30513912 )
2018
30
Secondary Hyperparathyroidism in Patients with Biliopancreatic Diversion After 10 Years of Follow-up, and Relationship with Vitamin D and Serum Calcium. ( 30523538 )
2018
31
Effect of Oral Alfacalcidol on Clinical Outcomes in Patients Without Secondary Hyperparathyroidism Receiving Maintenance Hemodialysis: The J-DAVID Randomized Clinical Trial. ( 30535217 )
2018
32
Effect of Hybrid Blood Purification Treatment on Secondary Hyperparathyroidism for Maintenance Hemodialysis Patients. ( 29649795 )
2018
33
Identification of Differential Transcriptional Patterns in Primary and Secondary Hyperparathyroidism. ( 29659895 )
2018
34
Etelcalcetide for Treating Secondary Hyperparathyroidism: An Evidence Review Group Evaluation of a NICE Single Technology Appraisal. ( 29691773 )
2018
35
Secondary Hyperparathyroidism and Protein-Energy Wasting in End-Stage Renal Disease. ( 29707907 )
2018
36
Longitudinal changes in bone and mineral metabolism after cessation of cinacalcet in dialysis patients with secondary hyperparathyroidism. ( 29764395 )
2018
37
Nutritional secondary hyperparathyroidism in two ponies. ( 29765869 )
2018
38
Therapeutic experience of severe and recurrent secondary hyperparathyroidism in a patient on hemodialysis for 18 years: A case report. ( 29768384 )
2018
39
The Impact of Surgical Strategy on the Consequences of Secondary Hyperparathyroidism. ( 29771721 )
2018
40
Risk factors for severe hypocalcemia after parathyroidectomy in dialysis patients with secondary hyperparathyroidism. ( 29773914 )
2018
41
All 25-hydroxyvitamin D-deficient Indian postmenopausal women do not have secondary hyperparathyroidism. ( 29806069 )
2018
42
Absent 99mTc-MIBI Uptake in the Thyroid Gland during Early Phase of Parathyroid Scintigraphy in Patients with Primary and Secondary Hyperparathyroidism. ( 29875850 )
2018
43
Severe secondary hyperparathyroidism in patients on haemodialysis is associated with a high initial serum parathyroid hormone and beta-CrossLaps level: Results from an incident cohort. ( 29912988 )
2018
44
Sagliker Syndrome in a Patient with Secondary Hyperparathyroidism and Chronic Renal Insufficiency: A Case Report. ( 29998151 )
2018
45
Treatment of secondary hyperparathyroidism: How do cinacalcet and etelcalcetide differ? ( 30009474 )
2018
46
Etelcalcetide (Parsabiv) for Secondary Hyperparathyroidism in Adults With Chronic Kidney Disease on Hemodialysis. ( 30013296 )
2018
47
Treatment of secondary hyperparathyroidism in patients on hemodialysis using a novel synthetic peptide calcimimetic, etelcalcetide: a short-term clinical study. ( 30027791 )
2018
48
Ischemic stroke in the setting of secondary hyperparathyroidism due to vitamin D deficiency. ( 30036550 )
2018
49
Head-to-head comparison of the new calcimimetic agent evocalcet with cinacalcet in Japanese hemodialysis patients with secondary hyperparathyroidism. ( 30049473 )
2018
50
Hypocalcemia-based prediction of hungry bone syndrome after parathyroidectomy in hemodialysis patients with refractory secondary hyperparathyroidism. ( 30064280 )
2018

Variations for Secondary Hyperparathyroidism of Renal Origin

Expression for Secondary Hyperparathyroidism of Renal Origin

Search GEO for disease gene expression data for Secondary Hyperparathyroidism of Renal Origin.

Pathways for Secondary Hyperparathyroidism of Renal Origin

GO Terms for Secondary Hyperparathyroidism of Renal Origin

Cellular components related to Secondary Hyperparathyroidism of Renal Origin according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 ALB BGLAP CALCA EPO FGF23 PTH
2 extracellular space GO:0005615 9.17 ALB BGLAP CALCA EPO FGF23 PTH

Biological processes related to Secondary Hyperparathyroidism of Renal Origin according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.88 CALCA EPO FGF23 PTH TNFRSF11B
2 cellular protein metabolic process GO:0044267 9.8 ALB CALCA FGF23
3 aging GO:0007568 9.8 BGLAP CALCA EPO
4 response to lipopolysaccharide GO:0032496 9.79 ACP5 CYP27B1 EPO
5 calcium ion transport GO:0006816 9.77 CYP27B1 PTH VDR
6 skeletal system development GO:0001501 9.73 BGLAP PTH TNFRSF11B VDR
7 ossification GO:0001503 9.72 ACP5 BGLAP CASR
8 cellular calcium ion homeostasis GO:0006874 9.67 CALCA CASR PTH VDR
9 embryo implantation GO:0007566 9.64 CALCA EPO
10 response to testosterone GO:0033574 9.63 BGLAP EPO
11 bone mineralization GO:0030282 9.63 BGLAP CYP27B1 PTH
12 bone resorption GO:0045453 9.61 ACP5 PTH
13 decidualization GO:0046697 9.61 CYP27B1 VDR
14 vasodilation GO:0042311 9.6 CALCA CASR
15 positive regulation of keratinocyte differentiation GO:0045618 9.58 CYP27B1 VDR
16 negative regulation of bone resorption GO:0045779 9.58 CALCA TNFRSF11B
17 regulation of bone mineralization GO:0030500 9.58 BGLAP CYP27B1 FGF23
18 response to inorganic substance GO:0010035 9.57 BGLAP TNFRSF11B
19 response to magnesium ion GO:0032026 9.56 FGF23 TNFRSF11B
20 phosphate ion homeostasis GO:0055062 9.54 FGF23 PTH
21 response to fibroblast growth factor GO:0071774 9.52 CASR PTH
22 negative regulation of calcium ion transport into cytosol GO:0010523 9.51 CALCA EPO
23 response to vitamin D GO:0033280 9.5 BGLAP CYP27B1 PTH
24 vitamin D catabolic process GO:0042369 9.49 CYP27B1 FGF23
25 response to estrogen GO:0043627 9.46 BGLAP CYP27B1 EPO TNFRSF11B
26 vitamin D metabolic process GO:0042359 9.43 CYP27B1 FGF23 VDR
27 cellular response to vitamin D GO:0071305 9.13 BGLAP CASR FGF23
28 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 8.8 CYP27B1 FGF23 VDR

Molecular functions related to Secondary Hyperparathyroidism of Renal Origin according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CALCA EPO PTH

Sources for Secondary Hyperparathyroidism of Renal Origin

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