MCID: SCN005
MIFTS: 31

Secondary Hypertrophic Osteoarthropathy

Categories: Bone diseases, Fetal diseases, Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Secondary Hypertrophic Osteoarthropathy

MalaCards integrated aliases for Secondary Hypertrophic Osteoarthropathy:

Name: Secondary Hypertrophic Osteoarthropathy 12 15 17
Osteoarthropathy, Secondary Hypertrophic 43 71
Hpoa - Hypertrophic Pulmonary Osteoarthropathy 12
Hypertrophic Pulmonary Osteoarthropathy 12
Bamberger-Marie Disease 12
Marie Bamberger Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10393
ICD9CM 34 731.2
MeSH 43 D010005
ICD10 32 M89.4
UMLS 71 C0029412

Summaries for Secondary Hypertrophic Osteoarthropathy

MalaCards based summary : Secondary Hypertrophic Osteoarthropathy, also known as osteoarthropathy, secondary hypertrophic, is related to primary hypertrophic osteoarthropathy and acroosteolysis, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Secondary Hypertrophic Osteoarthropathy is UBE2D1 (Ubiquitin Conjugating Enzyme E2 D1). The drugs Etoricoxib and Analgesics, Non-Narcotic have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and heart, and related phenotype is homeostasis/metabolism.

Related Diseases for Secondary Hypertrophic Osteoarthropathy

Diseases in the Primary Hypertrophic Osteoarthropathy family:

Hypertrophic Osteoarthropathy, Primary, Autosomal Dominant Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 2 Secondary Hypertrophic Osteoarthropathy

Diseases related to Secondary Hypertrophic Osteoarthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 primary hypertrophic osteoarthropathy 30.4 SLCO2A1 HPGD
2 acroosteolysis 30.2 SLCO2A1 HPGD
3 hypertrophic osteoarthropathy, primary, autosomal recessive, 1 11.5
4 periostitis 10.4
5 lung cancer susceptibility 3 10.4
6 neuroendocrine carcinoma 10.2
7 breast cancer 10.2
8 small cell cancer of the lung 10.2
9 cystic fibrosis 10.2
10 infant gynecomastia 10.2
11 gynecomastia 10.2
12 lung disease 10.2
13 liver fibroma 10.2 UBE2D1 IGF2
14 lymphoma, hodgkin, classic 10.2
15 immune deficiency disease 10.2
16 small cell carcinoma 10.2
17 bone resorption disease 10.2
18 echinococcosis 10.2
19 pulmonary tuberculosis 10.2
20 arthropathy 10.2
21 paraneoplastic syndromes 10.2
22 nasal cavity benign neoplasm 10.1 UBE2D1 CD34
23 angiomatous meningioma 10.1 UBE2D1 CD34
24 small intestine leiomyosarcoma 10.1 IGF2 CD34
25 kidney hemangiopericytoma 10.1 IGF2 CD34
26 orbital cancer 10.1 UBE2D1 CD34
27 benign fibrous mesothelioma 10.1 IGF2 CD34
28 prostate stromal sarcoma 10.1 UBE2D1 CD34
29 autoimmune disease 10.0
30 aortic valve disease 1 10.0
31 fibrosis of extraocular muscles, congenital, 1 10.0
32 renal cell carcinoma, nonpapillary 10.0
33 systemic lupus erythematosus 10.0
34 pulmonary fibrosis, idiopathic 10.0
35 pulmonary alveolar microlithiasis 10.0
36 infective endocarditis 10.0
37 lymphoma 10.0
38 bone disease 10.0
39 endocarditis 10.0
40 asbestosis 10.0
41 sarcoma 10.0
42 respiratory failure 10.0
43 coccidioidomycosis 10.0
44 malignant fibrous histiocytoma 10.0
45 exostosis 10.0
46 cervix carcinoma 10.0
47 interstitial lung disease 10.0
48 neurilemmoma 10.0
49 fibrosarcoma 10.0
50 lung benign neoplasm 10.0

Graphical network of the top 20 diseases related to Secondary Hypertrophic Osteoarthropathy:



Diseases related to Secondary Hypertrophic Osteoarthropathy

Symptoms & Phenotypes for Secondary Hypertrophic Osteoarthropathy

UMLS symptoms related to Secondary Hypertrophic Osteoarthropathy:


arthralgia, metatarsalgia

MGI Mouse Phenotypes related to Secondary Hypertrophic Osteoarthropathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.23 CD34 HPGD IGF2 NAB2 NPRL3 SLC34A2

Drugs & Therapeutics for Secondary Hypertrophic Osteoarthropathy

Drugs for Secondary Hypertrophic Osteoarthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoricoxib Approved, Investigational Phase 3 202409-33-4 123619
2 Analgesics, Non-Narcotic Phase 3
3 Cyclooxygenase 2 Inhibitors Phase 3
4 Analgesics Phase 3
5 Cyclooxygenase Inhibitors Phase 3
6 Anti-Inflammatory Agents Phase 3
7 Antirheumatic Agents Phase 3
8 Anti-Inflammatory Agents, Non-Steroidal Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Application of COX-2 Inhibitor for Treatment of Primary Hypertrophic Osteoarthropathy Unknown status NCT02438709 Phase 3 COX-2 inhibitor

Search NIH Clinical Center for Secondary Hypertrophic Osteoarthropathy

Cochrane evidence based reviews: osteoarthropathy, secondary hypertrophic

Genetic Tests for Secondary Hypertrophic Osteoarthropathy

Anatomical Context for Secondary Hypertrophic Osteoarthropathy

MalaCards organs/tissues related to Secondary Hypertrophic Osteoarthropathy:

40
Bone, Lung, Heart, Liver, Pancreas, Cervix

Publications for Secondary Hypertrophic Osteoarthropathy

Articles related to Secondary Hypertrophic Osteoarthropathy:

(show top 50) (show all 69)
# Title Authors PMID Year
1
Secondary Hypertrophic Osteoarthropathy Associated With Pediatric Primary Lung Squamous Cell Carcinoma. 61
29652703 2020
2
Pachydermoperiostosis (Touraine-Solente-Gole syndrome): a case report. 61
30786934 2019
3
Secondary hypertrophic osteoarthropathy in a male from the Early Medieval settlement of Lauchheim, Germany. 61
29496219 2018
4
Sterile Bronchopleural Fistula Following Surgical Removal of Primary Lung Leiomyoma Inducing Secondary Hypertrophic Osteoarthropathy. 61
29519996 2018
5
Pachydermoperiostosis in a patient with chronic hepatitis B virus infection referred as acromegaly: a case report. 61
29514715 2018
6
Secondary hypertrophic osteoarthropathy caused by non-pleural or pulmonary tumors. 61
28885355 2017
7
Graft Infection Masquerading as Rheumatologic Disease: a Rare Case of Aortobifemoral Graft Infection Presenting as Hypertrophic Osteoarthropathy. 61
28279724 2017
8
[Secondary hypertrophic osteoarthropathy (HOA) or Pierre-Marie Bamberger syndrome revealing bronchial adenocarcinoma]. 61
28819538 2017
9
Cutaneous manifestations of lung cancer. 61
27178690 2016
10
Blepharoptosis and hypertrophic osteoarthropathy: A case report. 61
27221686 2016
11
[If digital clubbing appears bear Marie-Bamberger disease in mind]. 61
26450436 2015
12
Non-traumatic calcifications/ossifications of the bone surface and soft tissues of the wrist, hand and fingers: a diagnostic approach. 61
25224813 2014
13
Hypertrophic osteoarthropathy and congenital heart disease: this is not casual. 61
24049086 2013
14
[Bronchial carcinoma and knee pain. Secondary hypertrophic osteoarthropathy]. 61
23052705 2013
15
[Painful swollen joints with weakness: what's behind all this? Case 1/2013]. 61
23361349 2013
16
Hypertrophic osteoarthropathy presenting as unilateral cellulitis with successful treatment using pamidronate disodium. 61
23050033 2012
17
Hypertrophy of the feet and ankles presenting in primary hypertrophic osteoarthropathy or pachydermoperiostosis: a case report. 61
22273836 2012
18
Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy. 61
22197487 2012
19
Touraine-Solente-Gole' syndrome. 61
22679327 2011
20
Prostaglandin E2 and bone turnover markers in the evaluation of primary hypertrophic osteoarthropathy (pachydermoperiostosis): a case report. 61
19455364 2009
21
An interesting case of pachydermoperiostosis with idiopathic myelofibrosis associated with monosomy 22. 61
19659869 2009
22
[Secondary hypertrophic osteoarthropathy to lung cancer: a case report]. 61
19547900 2009
23
Incidental solitary knee mass as the first manifestation of hidden lung cancer. 61
19013072 2009
24
Secondary hypertrophic osteoarthropathy on bone scintigraphy as a diagnosis of vascular prosthesis infection. 61
18392821 2008
25
[The role of medical imaging in paleoanthropology]. 61
18477957 2008
26
Hypertrophic osteoarthropathy: a palindrome with a pathogenic connotation. 61
18281863 2008
27
Secondary hypertrophic osteoarthropathy associated with solitary fibrous tumor of the lung. 61
17938018 2007
28
Secondary hypertrophic osteoarthropathy: new insights on pathogenesis and management. 61
20084716 2007
29
[Clinical case of the month. Pierre Marie Bamberger syndrome]. 61
16680997 2006
30
[A Tunisian case of pachydermoperiostosis]. 61
16681005 2006
31
Successful treatment of hypertrophic osteoarthropathy by gefitinib in a case with lung adenocarcinoma. 61
16080471 2005
32
[Pachydermoperiostosis: a report of two cases]. 61
15908876 2005
33
Pierre Marie-Bamberger syndrome (secondary hypertrophic osteoarthropathy). 61
15663658 2005
34
[Secondary hypertrophic osteoarthropathy in colitis ulcerosa--a case demonstration]. 61
15346312 2004
35
Secondary hypertrophic osteoarthropathy (HOA) mimicking primary HOA (pachydermoperiostitis or Touraine-Solente-Golé) syndrome. 61
14740519 2004
36
[An incomplete form of pachydermoperiostosis. Diagnosis of finger clubbing]. 61
12360756 2002
37
Hypertrophic osteoarthropathy caused by PGE1 in a patient with congestive heart failure during cardiac rehabilitation. 61
12060968 2002
38
[Non-neoplastic hypertrophic osteoarthropathy due to infected aortic prosthesis. Diagnostic imaging aspects]. 61
11405108 2001
39
[Secondary hypertrophic osteoarthropathy in tumor of the pancreas]]. 61
11413847 2001
40
[Differential diagnosis of osteoarthropathia hypertrophicans]. 61
11386109 2001
41
[Small-cell bronchial carcinoma with secondary hypertrophic osteoarthropathy]. 61
11116554 2000
42
[Secondary hypertrophic osteoarthropathy. Differential diagnosis of post-traumatic ossification of the interosseous crural membrane]. 61
10969548 2000
43
Hypertrophic osteoarthropathy in lung cancer: are the radiographic bone changes reversible after curative resection? 61
10949872 2000
44
[Secondary hypertrophic osteoarthropathy in a patient with pulmonary carcinoma]. 61
10914468 2000
45
[Periosteal reaction]. 61
10429428 1999
46
Secondary hypertrophic osteoarthropathy. 61
9542358 1998
47
A new syndrome of Crohn's disease and pachydermoperiostosis in a family. 61
8978365 1997
48
[A rare cause of Pierre Marie hypertrophic osteoarthropathy: subacute infectious endocarditis]. 61
9181149 1997
49
[Scintigraphy in the early diagnosis of the secondary hypertrophic osteoarthropathy syndrome]. 61
9769717 1997
50
Radiology case of the month. Digital clubbing, arthritis, and symmetric periostitis. Secondary hypertrophic osteoarthropathy (Marie-Bamberger syndrome). 61
8936939 1996

Variations for Secondary Hypertrophic Osteoarthropathy

Expression for Secondary Hypertrophic Osteoarthropathy

Search GEO for disease gene expression data for Secondary Hypertrophic Osteoarthropathy.

Pathways for Secondary Hypertrophic Osteoarthropathy

GO Terms for Secondary Hypertrophic Osteoarthropathy

Molecular functions related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 8.8 NAB2 CD34 ASCL4

Sources for Secondary Hypertrophic Osteoarthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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