MCID: SCN005
MIFTS: 30

Secondary Hypertrophic Osteoarthropathy

Categories: Bone diseases, Fetal diseases, Genetic diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Secondary Hypertrophic Osteoarthropathy

MalaCards integrated aliases for Secondary Hypertrophic Osteoarthropathy:

Name: Secondary Hypertrophic Osteoarthropathy 12 15 17
Osteoarthropathy, Secondary Hypertrophic 44 71
Hpoa - Hypertrophic Pulmonary Osteoarthropathy 12
Hypertrophic Pulmonary Osteoarthropathy 12
Bamberger-Marie Disease 12
Marie Bamberger Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10393
ICD9CM 34 731.2
MeSH 44 D010005
SNOMED-CT 67 46922002
ICD10 32 M89.4
UMLS 71 C0029412

Summaries for Secondary Hypertrophic Osteoarthropathy

MalaCards based summary : Secondary Hypertrophic Osteoarthropathy, also known as osteoarthropathy, secondary hypertrophic, is related to hypertrophic osteoarthropathy, primary, autosomal recessive, 1 and primary hypertrophic osteoarthropathy, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Secondary Hypertrophic Osteoarthropathy is SLCO2A1 (Solute Carrier Organic Anion Transporter Family Member 2A1), and among its related pathways/superpathways is Transport of vitamins, nucleosides, and related molecules. The drugs Etoricoxib and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, pancreas and cervix, and related phenotype is homeostasis/metabolism.

Related Diseases for Secondary Hypertrophic Osteoarthropathy

Diseases in the Primary Hypertrophic Osteoarthropathy family:

Hypertrophic Osteoarthropathy, Primary, Autosomal Dominant Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 2 Secondary Hypertrophic Osteoarthropathy

Diseases related to Secondary Hypertrophic Osteoarthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 hypertrophic osteoarthropathy, primary, autosomal recessive, 1 32.0 SLCO2A1 HPGD
2 primary hypertrophic osteoarthropathy 30.5 SLCO2A1 HPGD
3 acroosteolysis 30.2 SLCO2A1 HPGD
4 leiomyoma 29.6 IGF2 CD34
5 periostitis 10.4
6 lung cancer 10.4
7 lung cancer susceptibility 3 10.4
8 infant gynecomastia 10.2
9 gynecomastia 10.2
10 small cell cancer of the lung 10.2
11 cystic fibrosis 10.2
12 small cell carcinoma 10.2
13 bone resorption disease 10.2
14 echinococcosis 10.2
15 arthropathy 10.2
16 sarcomatoid carcinoma 10.2
17 bronchiectasis 10.2
18 paraneoplastic syndromes 10.2
19 neuroendocrine carcinoma 10.1
20 kidney hemangiopericytoma 10.1 IGF2 CD34
21 benign fibrous mesothelioma 10.1 IGF2 CD34
22 liver fibroma 10.1 IGF2 CD34
23 smooth muscle tumor 10.0 IGF2 CD34
24 breast hemangioma 10.0 CD34 AVP
25 autoimmune disease 10.0
26 renal cell carcinoma, nonpapillary 10.0
27 systemic lupus erythematosus 10.0
28 pulmonary fibrosis, idiopathic 10.0
29 immune deficiency disease 10.0
30 pulmonary alveolar microlithiasis 10.0
31 infective endocarditis 10.0
32 bone disease 10.0
33 lung sarcomatoid carcinoma 10.0
34 pemphigoid 10.0
35 endocarditis 10.0
36 asbestosis 10.0
37 respiratory failure 10.0
38 coccidioidomycosis 10.0
39 malignant fibrous histiocytoma 10.0
40 exostosis 10.0
41 cervix carcinoma 10.0
42 pulmonary tuberculosis 10.0
43 interstitial lung disease 10.0
44 neurilemmoma 10.0
45 fibrosarcoma 10.0
46 lung benign neoplasm 10.0
47 carcinosarcoma 10.0
48 fibrous histiocytoma 10.0
49 myoblastoma 10.0
50 lymphoepithelioma-like carcinoma 10.0

Graphical network of the top 20 diseases related to Secondary Hypertrophic Osteoarthropathy:



Diseases related to Secondary Hypertrophic Osteoarthropathy

Symptoms & Phenotypes for Secondary Hypertrophic Osteoarthropathy

UMLS symptoms related to Secondary Hypertrophic Osteoarthropathy:


arthralgia, metatarsalgia

MGI Mouse Phenotypes related to Secondary Hypertrophic Osteoarthropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.17 AVP CD34 HPGD IGF2 NAB2 SLC34A2

Drugs & Therapeutics for Secondary Hypertrophic Osteoarthropathy

Drugs for Secondary Hypertrophic Osteoarthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoricoxib Approved, Investigational Phase 3 202409-33-4 123619
2 Anti-Inflammatory Agents Phase 3
3 Analgesics, Non-Narcotic Phase 3
4 Cyclooxygenase 2 Inhibitors Phase 3
5 Cyclooxygenase Inhibitors Phase 3
6 Anti-Inflammatory Agents, Non-Steroidal Phase 3
7 Analgesics Phase 3
8 Antirheumatic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Application of COX-2 Inhibitor for Treatment of Primary Hypertrophic Osteoarthropathy Unknown status NCT02438709 Phase 3 COX-2 inhibitor

Search NIH Clinical Center for Secondary Hypertrophic Osteoarthropathy

Cochrane evidence based reviews: osteoarthropathy, secondary hypertrophic

Genetic Tests for Secondary Hypertrophic Osteoarthropathy

Anatomical Context for Secondary Hypertrophic Osteoarthropathy

MalaCards organs/tissues related to Secondary Hypertrophic Osteoarthropathy:

40
Bone, Pancreas, Cervix

Publications for Secondary Hypertrophic Osteoarthropathy

Articles related to Secondary Hypertrophic Osteoarthropathy:

(show top 50) (show all 70)
# Title Authors PMID Year
1
Secondary Hypertrophic Osteoarthropathy in Pediatric Hodgkin lymphoma. 61
32686912 2020
2
Secondary Hypertrophic Osteoarthropathy Associated With Pediatric Primary Lung Squamous Cell Carcinoma. 61
29652703 2020
3
Pachydermoperiostosis (Touraine-Solente-Gole syndrome): a case report. 61
30786934 2019
4
Secondary hypertrophic osteoarthropathy in a male from the Early Medieval settlement of Lauchheim, Germany. 61
29496219 2018
5
Pachydermoperiostosis in a patient with chronic hepatitis B virus infection referred as acromegaly: a case report. 61
29514715 2018
6
Sterile Bronchopleural Fistula Following Surgical Removal of Primary Lung Leiomyoma Inducing Secondary Hypertrophic Osteoarthropathy. 61
29519996 2018
7
Secondary hypertrophic osteoarthropathy caused by non-pleural or pulmonary tumors. 61
28885355 2017
8
Graft Infection Masquerading as Rheumatologic Disease: a Rare Case of Aortobifemoral Graft Infection Presenting as Hypertrophic Osteoarthropathy. 61
28279724 2017
9
[Secondary hypertrophic osteoarthropathy (HOA) or Pierre-Marie Bamberger syndrome revealing bronchial adenocarcinoma]. 61
28819538 2017
10
Cutaneous manifestations of lung cancer. 61
27178690 2016
11
Blepharoptosis and hypertrophic osteoarthropathy: A case report. 61
27221686 2016
12
[If digital clubbing appears bear Marie-Bamberger disease in mind]. 61
26450436 2015
13
Non-traumatic calcifications/ossifications of the bone surface and soft tissues of the wrist, hand and fingers: a diagnostic approach. 61
25224813 2014
14
Hypertrophic osteoarthropathy and congenital heart disease: this is not casual. 61
24049086 2013
15
[Bronchial carcinoma and knee pain. Secondary hypertrophic osteoarthropathy]. 61
23052705 2013
16
[Painful swollen joints with weakness: what's behind all this? Case 1/2013]. 61
23361349 2013
17
Hypertrophic osteoarthropathy presenting as unilateral cellulitis with successful treatment using pamidronate disodium. 61
23050033 2012
18
Hypertrophy of the feet and ankles presenting in primary hypertrophic osteoarthropathy or pachydermoperiostosis: a case report. 61
22273836 2012
19
Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy. 61
22197487 2012
20
Touraine-Solente-Gole' syndrome. 61
22679327 2011
21
Prostaglandin E2 and bone turnover markers in the evaluation of primary hypertrophic osteoarthropathy (pachydermoperiostosis): a case report. 61
19455364 2009
22
An interesting case of pachydermoperiostosis with idiopathic myelofibrosis associated with monosomy 22. 61
19659869 2009
23
[Secondary hypertrophic osteoarthropathy to lung cancer: a case report]. 61
19547900 2009
24
Incidental solitary knee mass as the first manifestation of hidden lung cancer. 61
19013072 2009
25
Secondary hypertrophic osteoarthropathy on bone scintigraphy as a diagnosis of vascular prosthesis infection. 61
18392821 2008
26
[The role of medical imaging in paleoanthropology]. 61
18477957 2008
27
Hypertrophic osteoarthropathy: a palindrome with a pathogenic connotation. 61
18281863 2008
28
Secondary hypertrophic osteoarthropathy associated with solitary fibrous tumor of the lung. 61
17938018 2007
29
Secondary hypertrophic osteoarthropathy: new insights on pathogenesis and management. 61
20084716 2007
30
[A Tunisian case of pachydermoperiostosis]. 61
16681005 2006
31
[Clinical case of the month. Pierre Marie Bamberger syndrome]. 61
16680997 2006
32
Successful treatment of hypertrophic osteoarthropathy by gefitinib in a case with lung adenocarcinoma. 61
16080471 2005
33
[Pachydermoperiostosis: a report of two cases]. 61
15908876 2005
34
Pierre Marie-Bamberger syndrome (secondary hypertrophic osteoarthropathy). 61
15663658 2005
35
[Secondary hypertrophic osteoarthropathy in colitis ulcerosa--a case demonstration]. 61
15346312 2004
36
Secondary hypertrophic osteoarthropathy (HOA) mimicking primary HOA (pachydermoperiostitis or Touraine-Solente-Golé) syndrome. 61
14740519 2004
37
[An incomplete form of pachydermoperiostosis. Diagnosis of finger clubbing]. 61
12360756 2002
38
Hypertrophic osteoarthropathy caused by PGE1 in a patient with congestive heart failure during cardiac rehabilitation. 61
12060968 2002
39
[Non-neoplastic hypertrophic osteoarthropathy due to infected aortic prosthesis. Diagnostic imaging aspects]. 61
11405108 2001
40
[Secondary hypertrophic osteoarthropathy in tumor of the pancreas]]. 61
11413847 2001
41
[Differential diagnosis of osteoarthropathia hypertrophicans]. 61
11386109 2001
42
[Small-cell bronchial carcinoma with secondary hypertrophic osteoarthropathy]. 61
11116554 2000
43
[Secondary hypertrophic osteoarthropathy. Differential diagnosis of post-traumatic ossification of the interosseous crural membrane]. 61
10969548 2000
44
Hypertrophic osteoarthropathy in lung cancer: are the radiographic bone changes reversible after curative resection? 61
10949872 2000
45
[Secondary hypertrophic osteoarthropathy in a patient with pulmonary carcinoma]. 61
10914468 2000
46
[Periosteal reaction]. 61
10429428 1999
47
Secondary hypertrophic osteoarthropathy. 61
9542358 1998
48
[Scintigraphy in the early diagnosis of the secondary hypertrophic osteoarthropathy syndrome]. 61
9769717 1997
49
A new syndrome of Crohn's disease and pachydermoperiostosis in a family. 61
8978365 1997
50
[A rare cause of Pierre Marie hypertrophic osteoarthropathy: subacute infectious endocarditis]. 61
9181149 1997

Variations for Secondary Hypertrophic Osteoarthropathy

Expression for Secondary Hypertrophic Osteoarthropathy

Search GEO for disease gene expression data for Secondary Hypertrophic Osteoarthropathy.

Pathways for Secondary Hypertrophic Osteoarthropathy

Pathways related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes

GO Terms for Secondary Hypertrophic Osteoarthropathy

Sources for Secondary Hypertrophic Osteoarthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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