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MCID: SCN005
MIFTS: 45

Secondary Hypertrophic Osteoarthropathy

Categories: Bone diseases, Fetal diseases, Genetic diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Secondary Hypertrophic Osteoarthropathy

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MalaCards integrated aliases for Secondary Hypertrophic Osteoarthropathy:

Name: Secondary Hypertrophic Osteoarthropathy 12 15 17
Osteoarthropathy, Secondary Hypertrophic 45 74
Hpoa - Hypertrophic Pulmonary Osteoarthropathy 12
Hypertrophic Pulmonary Osteoarthropathy 12
Bamberger-Marie Disease 12
Marie Bamberger Disease 12

Classifications:

MalaCards categories:
Global: Fetal diseases Genetic diseases Rare diseases
Anatomical: Bone diseases Skin diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:10393
ICD9CM 36 731.2
MeSH 45 D010005
SNOMED-CT 69 46922002
ICD10 34 M89.4
UMLS 74 C0029412
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Summaries for Secondary Hypertrophic Osteoarthropathy

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MalaCards based summary : Secondary Hypertrophic Osteoarthropathy, also known as osteoarthropathy, secondary hypertrophic, is related to bronchus cancer and periostitis, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Secondary Hypertrophic Osteoarthropathy is NPRL3 (NPR3 Like, GATOR1 Complex Subunit), and among its related pathways/superpathways are G alpha (s) signalling events and MNAR-PELP1 and Estrogen Receptor Interaction. The drugs Etoricoxib and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and heart, and related phenotypes are homeostasis/metabolism and no phenotypic analysis

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Related Diseases for Secondary Hypertrophic Osteoarthropathy

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Diseases in the Primary Hypertrophic Osteoarthropathy family:

Hypertrophic Osteoarthropathy, Primary, Autosomal Dominant Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 2 Secondary Hypertrophic Osteoarthropathy

Diseases related to Secondary Hypertrophic Osteoarthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 bronchus cancer 30.6 AVP CRP POMC
2 periostitis 30.5 IL1RN SLCO2A1
3 hypertrophic osteoarthropathy, primary, autosomal recessive, 1 11.4
4 central nervous system germinoma 10.4 AVP POMC
5 tuberculous epididymitis 10.4 AVP POMC
6 central nervous system germ cell tumor 10.4 AVP POMC
7 inappropriate adh syndrome 10.4 AVP POMC
8 prostate adenoid cystic carcinoma 10.3 HRAS POMC
9 acute thyroiditis 10.3 CALCA POMC
10 pancreatic cystadenocarcinoma 10.3 CALCA KRAS
11 sigmoid neoplasm 10.3 HRAS KRAS
12 olfactory nerve neoplasm 10.3 AVP POMC
13 apocrine adenoma 10.3 HRAS KRAS
14 sarcoma 10.3
15 periampullary adenoma 10.3 HRAS KRAS
16 paronychia 10.3 HRAS KRAS
17 schimmelpenning-feuerstein-mims syndrome 10.3 HRAS KRAS
18 bile duct cysts 10.3 HRAS KRAS
19 hypoadrenalism 10.3 CALCA POMC
20 lung oat cell carcinoma 10.3 AVP CALCA POMC
21 aggressive digital papillary adenocarcinoma 10.3 HRAS KRAS
22 appendix disease 10.2 HRAS KRAS
23 sepsis in premature infants 10.2 CALCA CRP
24 lung adenoid cystic carcinoma 10.2 HRAS KRAS
25 suppurative thyroiditis 10.2 CALCA CRP
26 discitis 10.2 CALCA CRP
27 paralytic ileus 10.2 AVP CRP
28 mucinous lung adenocarcinoma 10.2 HRAS KRAS ROS1
29 adenosquamous lung carcinoma 10.2 HRAS KRAS ROS1
30 diclofenac allergy 10.2 ATP12A ATP4A
31 gastroduodenal crohn's disease 10.2 ATP12A ATP4A
32 neonatal candidiasis 10.2 ATP12A ATP4A
33 respiratory system cancer 10.2 HRAS KRAS ROS1
34 photoallergic dermatitis 10.2 ATP12A ATP4A
35 osteitis fibrosa 10.2 BGLAP CALCA
36 cell type benign neoplasm 10.2 HRAS KRAS POMC
37 squamous papillomatosis 10.2 ATP12A ATP4A
38 cryopyrin-associated periodic syndrome 10.2 CRP IL1RN
39 toxic megacolon 10.1 ATP12A ATP4A
40 aspiration pneumonitis 10.1 ATP12A ATP4A
41 osteogenic sarcoma 10.1
42 adenocarcinoma 10.1
43 thymic carcinoma 10.1
44 gastric antral vascular ectasia 10.1 ATP12A ATP4A
45 thyroid cancer, nonmedullary, 2 10.1 CALCA HRAS POMC
46 esophageal candidiasis 10.1 ATP12A ATP4A
47 anal canal adenocarcinoma 10.1 HRAS KRAS
48 hyper-igd syndrome 10.1 CRP IL1RN
49 acute laryngitis 10.1 ATP12A ATP4A
50 laryngitis 10.1 ATP12A ATP4A

Graphical network of the top 20 diseases related to Secondary Hypertrophic Osteoarthropathy:



Diseases related to Secondary Hypertrophic Osteoarthropathy
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Symptoms & Phenotypes for Secondary Hypertrophic Osteoarthropathy

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UMLS symptoms related to Secondary Hypertrophic Osteoarthropathy:


arthralgia, metatarsalgia

MGI Mouse Phenotypes related to Secondary Hypertrophic Osteoarthropathy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.9 ATP12A ATP4A AVP CRP GAST HRAS
2 no phenotypic analysis MP:0003012 9.43 AVP HRAS KRAS NPRL3 POMC ROS1
3 renal/urinary system MP:0005367 9.1 ATP12A AVP HRAS KRAS POMC SLCO2A1
Sources

Drugs & Therapeutics for Secondary Hypertrophic Osteoarthropathy

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Drugs for Secondary Hypertrophic Osteoarthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoricoxib Approved, Investigational Phase 3 202409-33-4 123619
2 Peripheral Nervous System Agents Phase 3
3 Anti-Inflammatory Agents Phase 3
4 Cyclooxygenase Inhibitors Phase 3
5 Antirheumatic Agents Phase 3
6 Analgesics, Non-Narcotic Phase 3
7 Analgesics Phase 3
8 Cyclooxygenase 2 Inhibitors Phase 3
9 Anti-Inflammatory Agents, Non-Steroidal Phase 3
10
Spironolactone Approved Phase 1 1952-01-7, 52-01-7 5833
11
Captopril Approved Phase 1 62571-86-2 44093
12
Carvedilol Approved, Investigational Phase 1 72956-09-3 2585
13
Calcium Approved, Nutraceutical Phase 1 7440-70-2 271
14 Adrenergic beta-Antagonists Phase 1
15 Mineralocorticoids Phase 1
16 Adrenergic alpha-1 Receptor Antagonists Phase 1
17 Antioxidants Phase 1
18 Natriuretic Agents Phase 1
19 Neurotransmitter Agents Phase 1
20 Hormone Antagonists Phase 1
21 Adrenergic alpha-Antagonists Phase 1
22 Vasodilator Agents Phase 1
23 Antihypertensive Agents Phase 1
24 Adrenergic Agents Phase 1
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
26 calcium channel blockers Phase 1
27 Hormones Phase 1
28 Adrenergic Antagonists Phase 1
29 diuretics Phase 1
30
protease inhibitors Phase 1
31 Angiotensin-Converting Enzyme Inhibitors Phase 1
32 Diuretics, Potassium Sparing Phase 1
33 Mineralocorticoid Receptor Antagonists Phase 1
34 HIV Protease Inhibitors Phase 1
35 Protective Agents Phase 1
36 Calcium, Dietary Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect Observation Study of COX-2 Inhibitor to Treat Primary Hypertrophic Osteoarthropathy Unknown status NCT02438709 Phase 3 COX-2 inhibitor
2 Spironolactone Combined With Captopril and Carvedilol for the Treatment of Pulmonary Arterial Hypertension Completed NCT00240656 Phase 1 spironolactone captopril carvedilol
3 Investigation of the Prevalence of Hepatopulmonary Syndrome in Cirrhosis Patients Caused by Hepatitis B in Western China Recruiting NCT03435406

Search NIH Clinical Center for Secondary Hypertrophic Osteoarthropathy

Cochrane evidence based reviews: osteoarthropathy, secondary hypertrophic

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Genetic Tests for Secondary Hypertrophic Osteoarthropathy

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Anatomical Context for Secondary Hypertrophic Osteoarthropathy

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MalaCards organs/tissues related to Secondary Hypertrophic Osteoarthropathy:

42
Thyroid, Bone, Heart, Cervix, Skin, Pancreas, Prostate
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Publications for Secondary Hypertrophic Osteoarthropathy

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Articles related to Secondary Hypertrophic Osteoarthropathy:

(show all 22)
# Title Authors Year
1
Sterile Bronchopleural Fistula Following Surgical Removal of Primary Lung Leiomyoma Inducing Secondary Hypertrophic Osteoarthropathy. ( 29519996 )
2018
2
Secondary hypertrophic osteoarthropathy in a male from the Early Medieval settlement of Lauchheim, Germany. ( 29496219 )
2018
3
Secondary Hypertrophic Osteoarthropathy Associated With Pediatric Primary Lung Squamous Cell Carcinoma. ( 29652703 )
2018
4
Secondary hypertrophic osteoarthropathy caused by non-pleural or pulmonary tumors. ( 28885355 )
2017
5
[Secondary hypertrophic osteoarthropathy to lung cancer: a case report]. ( 19547900 )
2009
6
Secondary hypertrophic osteoarthropathy on bone scintigraphy as a diagnosis of vascular prosthesis infection. ( 18392821 )
2008
7
Secondary hypertrophic osteoarthropathy: new insights on pathogenesis and management. ( 20084716 )
2007
8
Secondary hypertrophic osteoarthropathy associated with solitary fibrous tumor of the lung. ( 17938018 )
2007
9
Pierre Marie-Bamberger syndrome (secondary hypertrophic osteoarthropathy). ( 15663658 )
2005
10
Secondary hypertrophic osteoarthropathy (HOA) mimicking primary HOA (pachydermoperiostitis or Touraine-Solente-Golé) syndrome. ( 14740519 )
2004
11
Secondary hypertrophic osteoarthropathy. ( 9542358 )
1998
12
Radiology case of the month. Digital clubbing, arthritis, and symmetric periostitis. Secondary hypertrophic osteoarthropathy (Marie-Bamberger syndrome). ( 8936939 )
1996
13
Pathogenesis of secondary hypertrophic osteoarthropathy: a hypothesis. ( 2703038 )
1989
14
Secondary hypertrophic osteoarthropathy in two children with humoral immunodeficiencies. ( 3372472 )
1988
15
Case report 126: secondary hypertrophic osteoarthropathy associated with excavating pulmonary metastases from squamous cell carcinoma of the cervix. ( 7209583 )
1980
16
Radionuclide demonstration of relative increased blood flow in uniappendicular secondary hypertrophic osteoarthropathy. ( 709981 )
1978
17
Delayed onset of secondary hypertrophic osteoarthropathy. ( 204179 )
1978
18
Secondary hypertrophic osteoarthropathy. An unusual cause of arthritis in childhood. ( 1067092 )
1976
19
Positive 99mTc-polyphosphate bone scan in a case of secondary hypertrophic osteoarthropathy. ( 4818305 )
1974
20
SECONDARY HYPERTROPHIC OSTEOARTHROPATHY AND ACANTHOSIS NIGRICANS. RESTUDY OF A CASE SIMULATING PACHYDERMOPERIOSTOSIS. ( 14096345 )
1964
21
Secondary hypertrophic osteoarthropathy. ( 13600644 )
1958
22
Secondary hypertrophic osteoarthropathy in congenital heart disease. ( 20255270 )
1947
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Variations for Secondary Hypertrophic Osteoarthropathy

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Expression for Secondary Hypertrophic Osteoarthropathy

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Search GEO for disease gene expression data for Secondary Hypertrophic Osteoarthropathy.
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Pathways for Secondary Hypertrophic Osteoarthropathy

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Pathways related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
G alpha (s) signalling events 67
11.71 AVP CALCA POMC
2
MNAR-PELP1 and Estrogen Receptor Interaction 65
10.77 HRAS KRAS
3
CD209 (DC-SIGN) signaling 67
10.66 HRAS KRAS
4
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling 1
10.56 HRAS KRAS
5
Development_Leptin signaling via JAK/STAT and MAPK cascades 23
Show member pathways
 10.28 CRP HRAS POMC
6
p38MAPK events 67
10.27 HRAS KRAS
7
Secretion of Hydrochloric Acid in Parietal Cells 1
9.65 ATP4A GAST
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GO Terms for Secondary Hypertrophic Osteoarthropathy

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Cellular components related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 ATP4A AVP BGLAP CALCA CRP GAST

Biological processes related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of long-term neuronal synaptic plasticity GO:0048169 9.43 HRAS KRAS
2 cellular sodium ion homeostasis GO:0006883 9.4 ATP12A ATP4A
3 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.37 ATP12A ATP4A
4 response to glucocorticoid GO:0051384 9.33 BGLAP IL1RN KRAS
5 cellular potassium ion homeostasis GO:0030007 9.32 ATP12A ATP4A
6 sodium ion export across plasma membrane GO:0036376 9.26 ATP12A ATP4A
7 regulation of signaling receptor activity GO:0010469 9.02 AVP CALCA GAST IL1RN POMC
8 response to isolation stress GO:0035900 8.96 HRAS KRAS

Molecular functions related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A
3 hormone activity GO:0005179 8.92 AVP CALCA GAST POMC
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Sources for Secondary Hypertrophic Osteoarthropathy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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