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MCID: SCN005
MIFTS: 40

Secondary Hypertrophic Osteoarthropathy

Categories: Bone diseases, Fetal diseases, Genetic diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Secondary Hypertrophic Osteoarthropathy

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MalaCards integrated aliases for Secondary Hypertrophic Osteoarthropathy:

Name: Secondary Hypertrophic Osteoarthropathy 12 15
Osteoarthropathy, Secondary Hypertrophic 44 73
Hpoa - Hypertrophic Pulmonary Osteoarthropathy 12
Hypertrophic Pulmonary Osteoarthropathy 12
Bamberger-Marie Disease 12
Marie Bamberger Disease 12

Classifications:

MalaCards categories:
Global: Fetal diseases Genetic diseases Rare diseases
Anatomical: Bone diseases Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:10393
ICD10 33 M89.4
ICD9CM 35 731.2
MeSH 44 D010005
SNOMED-CT 68 46922002
UMLS 73 C0029412
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Summaries for Secondary Hypertrophic Osteoarthropathy

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MalaCards based summary : Secondary Hypertrophic Osteoarthropathy, also known as osteoarthropathy, secondary hypertrophic, is related to hypertrophic osteoarthropathy, primary, autosomal recessive, 1 and sarcoma, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Secondary Hypertrophic Osteoarthropathy is SLCO2A1 (Solute Carrier Organic Anion Transporter Family Member 2A1), and among its related pathways/superpathways are Signaling by FGFR2 and G alpha (s) signalling events. The drugs Captopril and Spironolactone have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and lung, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

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Related Diseases for Secondary Hypertrophic Osteoarthropathy

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Diseases in the Primary Hypertrophic Osteoarthropathy family:

Hypertrophic Osteoarthropathy, Primary, Autosomal Dominant Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 2 Secondary Hypertrophic Osteoarthropathy

Diseases related to Secondary Hypertrophic Osteoarthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 hypertrophic osteoarthropathy, primary, autosomal recessive, 1 11.3
2 sarcoma 10.2
3 caffey disease 10.2 GALNT3 SLCO2A1
4 central nervous system germinoma 10.2 AVP POMC
5 tuberculous epididymitis 10.2 AVP POMC
6 central nervous system germ cell tumor 10.2 AVP POMC
7 bronchus cancer 10.2 AVP POMC
8 inappropriate adh syndrome 10.2 AVP POMC
9 olfactory nerve neoplasm 10.2 AVP POMC
10 tumoral calcinosis, normophosphatemic, familial 10.2 CALCA GALNT3
11 syndrome of inappropriate antidiuretic hormone 10.2 AVP POMC
12 acute thyroiditis 10.2 CALCA POMC
13 hypoadrenalism 10.2 CALCA POMC
14 cervix small cell carcinoma 10.2 AVP POMC
15 diabetes insipidus, neurohypophyseal 10.2 AVP POMC
16 osteogenic sarcoma 10.1
17 thymus cancer 10.1
18 thyroid sarcoma 10.1 CALCA KCNJ11
19 cloacogenic carcinoma 10.1 CALCA POMC
20 cranial nerve malignant neoplasm 10.1 AVP POMC
21 arthritis 10.1
22 squamous cell carcinoma 10.1
23 pancreatic cystadenocarcinoma 10.1 CALCA KRAS
24 premenstrual tension 10.1 AVP POMC
25 infant botulism 10.1 AVP KCNJ11
26 chromophobe adenoma 10.1 AVP POMC
27 oculomotor nerve paralysis 10.1 AVP SMUG1
28 third cranial nerve disease 10.1 AVP SMUG1
29 testicular leydig cell tumor 10.1 POMC SMUG1
30 pericardial tuberculosis 10.1 POMC SMUG1
31 mineral metabolism disease 10.1 CALCA GALNT3 POMC
32 lung oat cell carcinoma 10.1 AVP CALCA POMC
33 plexopathy 10.1 AVP SMUG1
34 anomalous left coronary artery from the pulmonary artery 10.0 KCNJ11 SMUG1
35 small cell cancer of the lung 10.0 AVP CALCA POMC
36 prostate adenoid cystic carcinoma 10.0 HRAS POMC
37 mature teratoma 10.0 KRAS SMUG1
38 ectopic cushing syndrome 10.0 POMC SMUG1
39 acroosteolysis 10.0
40 systemic lupus erythematosus 10.0
41 cystic fibrosis 10.0
42 pulmonary alveolar microlithiasis 10.0
43 asbestosis 10.0
44 pneumocystosis 10.0
45 infant gynecomastia 10.0
46 gynecomastia 10.0
47 cervix carcinoma 10.0
48 neurilemmoma 10.0
49 myoblastoma 10.0
50 pneumonia 10.0

Graphical network of the top 20 diseases related to Secondary Hypertrophic Osteoarthropathy:



Diseases related to Secondary Hypertrophic Osteoarthropathy
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Symptoms & Phenotypes for Secondary Hypertrophic Osteoarthropathy

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UMLS symptoms related to Secondary Hypertrophic Osteoarthropathy:


arthralgia, metatarsalgia

GenomeRNAi Phenotypes related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 GALNT3 HRAS KCNJ11 KRAS POMC

MGI Mouse Phenotypes related to Secondary Hypertrophic Osteoarthropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 AVP GALNT3 HRAS KCNJ11 KRAS NPRL3
2 cardiovascular system MP:0005385 9.87 GALNT3 HRAS KCNJ11 KRAS NPRL3 POMC
3 integument MP:0010771 9.63 GALNT3 HRAS KCNJ11 KRAS NPRL3 POMC
4 no phenotypic analysis MP:0003012 9.43 AVP HRAS KCNJ11 KRAS NPRL3 POMC
5 renal/urinary system MP:0005367 9.1 AVP GALNT3 HRAS KRAS POMC SLCO2A1
Sources

Drugs & Therapeutics for Secondary Hypertrophic Osteoarthropathy

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Drugs for Secondary Hypertrophic Osteoarthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Captopril Approved Phase 1 62571-86-2 44093
2
Spironolactone Approved Phase 1 52-01-7, 1952-01-7 5833
3
Carvedilol Approved, Investigational Phase 1 72956-09-3 2585
4 Adrenergic alpha-1 Receptor Antagonists Phase 1
5 Vasodilator Agents Phase 1
6 Diuretics, Potassium Sparing Phase 1
7 Adrenergic Antagonists Phase 1
8 Adrenergic alpha-Antagonists Phase 1
9 Adrenergic beta-Antagonists Phase 1
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
11 Mineralocorticoids Phase 1
12 Hormone Antagonists Phase 1
13 Hormones Phase 1
14
protease inhibitors Phase 1
15 diuretics Phase 1
16 Adrenergic Agents Phase 1
17 HIV Protease Inhibitors Phase 1
18 Angiotensin-Converting Enzyme Inhibitors Phase 1
19 Neurotransmitter Agents Phase 1
20 Mineralocorticoid Receptor Antagonists Phase 1
21 Antihypertensive Agents Phase 1
22 Natriuretic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Spironolactone Combined With Captopril and Carvedilol for the Treatment of Pulmonary Arterial Hypertension Completed NCT00240656 Phase 1 spironolactone captopril carvedilol
2 Investigation of the Prevalence of Hepatopulmonary Syndrome in Cirrhosis Patients Caused by Hepatitis B in Western China Recruiting NCT03435406

Search NIH Clinical Center for Secondary Hypertrophic Osteoarthropathy

Cochrane evidence based reviews: osteoarthropathy, secondary hypertrophic

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Genetic Tests for Secondary Hypertrophic Osteoarthropathy

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Anatomical Context for Secondary Hypertrophic Osteoarthropathy

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MalaCards organs/tissues related to Secondary Hypertrophic Osteoarthropathy:

41
Bone, Skin, Lung, Cervix, Ovary, Pancreas, Thyroid
Sources

Publications for Secondary Hypertrophic Osteoarthropathy

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Articles related to Secondary Hypertrophic Osteoarthropathy:

(show all 22)
# Title Authors Year
1
Secondary Hypertrophic Osteoarthropathy Associated With Pediatric Primary Lung Squamous Cell Carcinoma. ( 29652703 )
2018
2
Secondary hypertrophic osteoarthropathy in a male from the Early Medieval settlement of Lauchheim, Germany. ( 29496219 )
2018
3
Sterile Bronchopleural Fistula Following Surgical Removal of Primary Lung Leiomyoma Inducing Secondary Hypertrophic Osteoarthropathy. ( 29519996 )
2018
4
Secondary hypertrophic osteoarthropathy caused by non-pleural or pulmonary tumors. ( 28885355 )
2017
5
[Secondary hypertrophic osteoarthropathy to lung cancer: a case report]. ( 19547900 )
2009
6
Secondary hypertrophic osteoarthropathy on bone scintigraphy as a diagnosis of vascular prosthesis infection. ( 18392821 )
2008
7
Secondary hypertrophic osteoarthropathy associated with solitary fibrous tumor of the lung. ( 17938018 )
2007
8
Secondary hypertrophic osteoarthropathy: new insights on pathogenesis and management. ( 20084716 )
2007
9
Pierre Marie-Bamberger syndrome (secondary hypertrophic osteoarthropathy). ( 15663658 )
2005
10
Secondary hypertrophic osteoarthropathy (HOA) mimicking primary HOA (pachydermoperiostitis or Touraine-Solente-GolAc) syndrome. ( 14740519 )
2004
11
Secondary hypertrophic osteoarthropathy. ( 9542358 )
1998
12
Radiology case of the month. Digital clubbing, arthritis, and symmetric periostitis. Secondary hypertrophic osteoarthropathy (Marie-Bamberger syndrome). ( 8936939 )
1996
13
Pathogenesis of secondary hypertrophic osteoarthropathy: a hypothesis. ( 2703038 )
1989
14
Secondary hypertrophic osteoarthropathy in two children with humoral immunodeficiencies. ( 3372472 )
1988
15
Case report 126: secondary hypertrophic osteoarthropathy associated with excavating pulmonary metastases from squamous cell carcinoma of the cervix. ( 7209583 )
1980
16
Radionuclide demonstration of relative increased blood flow in uniappendicular secondary hypertrophic osteoarthropathy. ( 709981 )
1978
17
Delayed onset of secondary hypertrophic osteoarthropathy. ( 204179 )
1978
18
Secondary hypertrophic osteoarthropathy. An unusual cause of arthritis in childhood. ( 1067092 )
1976
19
Positive 99mTc-polyphosphate bone scan in a case of secondary hypertrophic osteoarthropathy. ( 4818305 )
1974
20
SECONDARY HYPERTROPHIC OSTEOARTHROPATHY AND ACANTHOSIS NIGRICANS. RESTUDY OF A CASE SIMULATING PACHYDERMOPERIOSTOSIS. ( 14096345 )
1964
21
Secondary hypertrophic osteoarthropathy. ( 13600644 )
1958
22
Secondary hypertrophic osteoarthropathy in congenital heart disease. ( 20255270 )
1947
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Variations for Secondary Hypertrophic Osteoarthropathy

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Expression for Secondary Hypertrophic Osteoarthropathy

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Search GEO for disease gene expression data for Secondary Hypertrophic Osteoarthropathy.
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Pathways for Secondary Hypertrophic Osteoarthropathy

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Pathways related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Signaling by FGFR2 66
Show member pathways
 11.87 GALNT3 HRAS KRAS
2
G alpha (s) signalling events 66
11.3 AVP CALCA POMC
3
BDNF-TrkB Signaling 1
11.04 HRAS KRAS
4
Development_Leptin signaling via JAK/STAT and MAPK cascades 22
Show member pathways
 10.97 HRAS POMC
5
Extracellular vesicle-mediated signaling in recipient cells 1
10.95 HRAS KRAS
6
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities 1
10.93 HRAS KRAS
7
Bisphosphonate Pathway, Pharmacodynamics 61
Show member pathways
 10.9 HRAS KRAS
8
EGFR Transactivation by Gastrin 66
Show member pathways
 10.78 HRAS KRAS
9
MNAR-PELP1 and Estrogen Receptor Interaction 64
10.68 HRAS KRAS
10
CD209 (DC-SIGN) signaling 66
10.6 HRAS KRAS
11
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling 1
10.46 HRAS KRAS
12
p38MAPK events 66
9.74 HRAS KRAS
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GO Terms for Secondary Hypertrophic Osteoarthropathy

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Biological processes related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.43 AVP CALCA POMC
2 response to testosterone GO:0033574 9.16 AVP KCNJ11
3 regulation of long-term neuronal synaptic plasticity GO:0048169 8.96 HRAS KRAS
4 response to isolation stress GO:0035900 8.62 HRAS KRAS

Molecular functions related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 AVP CALCA POMC
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Sources for Secondary Hypertrophic Osteoarthropathy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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