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MCID: SCN005
MIFTS: 44

Secondary Hypertrophic Osteoarthropathy

Categories: Bone diseases, Genetic diseases, Rare diseases, Fetal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Secondary Hypertrophic Osteoarthropathy

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MalaCards integrated aliases for Secondary Hypertrophic Osteoarthropathy:

Name: Secondary Hypertrophic Osteoarthropathy 12 15
Osteoarthropathy, Secondary Hypertrophic 44 73
Hpoa - Hypertrophic Pulmonary Osteoarthropathy 12
Hypertrophic Pulmonary Osteoarthropathy 12
Bamberger-Marie Disease 12
Marie Bamberger Disease 12

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Fetal diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:10393
ICD10 33 M89.4
ICD9CM 35 731.2
MeSH 44 D010005
UMLS 73 C0029412
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Summaries for Secondary Hypertrophic Osteoarthropathy

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MalaCards based summary : Secondary Hypertrophic Osteoarthropathy, also known as osteoarthropathy, secondary hypertrophic, is related to hypertrophic osteoarthropathy, primary, autosomal recessive, 1 and caffey disease, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Secondary Hypertrophic Osteoarthropathy is SLCO2A1 (Solute Carrier Organic Anion Transporter Family Member 2A1), and among its related pathways/superpathways are Phospholipase D signaling pathway and Signaling by FGFR2. The drugs Etoricoxib and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and cervix, and related phenotypes are homeostasis/metabolism and no phenotypic analysis

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Related Diseases for Secondary Hypertrophic Osteoarthropathy

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Diseases in the Primary Hypertrophic Osteoarthropathy family:

Hypertrophic Osteoarthropathy, Primary, Autosomal Dominant Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 2 Secondary Hypertrophic Osteoarthropathy

Diseases related to Secondary Hypertrophic Osteoarthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 hypertrophic osteoarthropathy, primary, autosomal recessive, 1 11.2
2 caffey disease 10.6 GALNT3 SLCO2A1
3 central nervous system germinoma 10.6 AVP POMC
4 tuberculous epididymitis 10.6 AVP POMC
5 central nervous system germ cell tumor 10.6 AVP POMC
6 inappropriate adh syndrome 10.6 AVP POMC
7 tumoral calcinosis, normophosphatemic, familial 10.5 CALCA GALNT3
8 syndrome of inappropriate antidiuretic hormone 10.5 AVP POMC
9 central nervous system organ benign neoplasm 10.5 AVP POMC
10 cervix small cell carcinoma 10.5 AVP POMC
11 acute thyroiditis 10.5 CALCA POMC
12 diabetes insipidus, neurohypophyseal 10.4 AVP POMC
13 hypoadrenalism 10.4 CALCA POMC
14 extraosseous osteosarcoma 10.3 GALNT3 SMUG1
15 oculomotor nerve paralysis 10.3 AVP SMUG1
16 third cranial nerve disease 10.3 AVP SMUG1
17 premenstrual tension 10.3 AVP POMC
18 cloacogenic carcinoma 10.3 CALCA POMC
19 laryngeal tuberculosis 10.2 POMC SMUG1
20 chromophobe adenoma 10.2 AVP POMC
21 testicular leydig cell tumor 10.2 POMC SMUG1
22 pancreatic cystadenocarcinoma 10.2 CALCA KRAS
23 pericardial tuberculosis 10.2 POMC SMUG1
24 plexopathy 10.2 AVP SMUG1
25 rectosigmoid junction neoplasm 10.1 KRAS SMUG1
26 mature teratoma 10.1 KRAS SMUG1
27 mineral metabolism disease 10.1 CALCA GALNT3 POMC
28 prostate adenoid cystic carcinoma 10.0 HRAS POMC
29 ectopic cushing syndrome 10.0 POMC SMUG1
30 thymus cancer 10.0
31 small cell cancer of the lung 10.0 AVP CALCA POMC
32 arthritis 10.0
33 squamous cell carcinoma 10.0
34 sigmoid neoplasm 9.9 HRAS KRAS
35 apocrine adenoma 9.9 HRAS KRAS
36 schimmelpenning-feuerstein-mims syndrome 9.9 HRAS KRAS
37 periampullary adenoma 9.9 HRAS KRAS
38 paronychia 9.9 HRAS KRAS
39 anus cancer 9.9 KRAS SMUG1
40 bile duct cysts 9.9 HRAS KRAS
41 kleine-levin hibernation syndrome 9.9 POMC SMUG1
42 aggressive digital papillary adenocarcinoma 9.9 HRAS KRAS
43 nasal cavity adenocarcinoma 9.9 HRAS KRAS
44 anal canal adenocarcinoma 9.9 HRAS KRAS
45 thyroid carcinoma, familial medullary 9.9 CALCA KRAS POMC
46 ovary serous adenocarcinoma 9.9 HRAS KRAS
47 ampulla of vater neoplasm 9.9 HRAS KRAS
48 acanthosis nigricans 9.8
49 lung cancer 9.8
50 hemangiopericytoma, malignant 9.8

Graphical network of the top 20 diseases related to Secondary Hypertrophic Osteoarthropathy:



Diseases related to Secondary Hypertrophic Osteoarthropathy
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Symptoms & Phenotypes for Secondary Hypertrophic Osteoarthropathy

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UMLS symptoms related to Secondary Hypertrophic Osteoarthropathy:


arthralgia, metatarsalgia

MGI Mouse Phenotypes related to Secondary Hypertrophic Osteoarthropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.76 AVP GALNT3 HRAS KRAS NPRL3 POMC
2 no phenotypic analysis MP:0003012 9.35 AVP HRAS KRAS NPRL3 POMC
3 renal/urinary system MP:0005367 9.1 AVP GALNT3 HRAS KRAS POMC SLCO2A1
Sources

Drugs & Therapeutics for Secondary Hypertrophic Osteoarthropathy

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Drugs for Secondary Hypertrophic Osteoarthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoricoxib Approved, Investigational Phase 3 202409-33-4 123619
2 Analgesics Phase 3
3 Analgesics, Non-Narcotic Phase 3
4 Anti-Inflammatory Agents Phase 3
5 Anti-Inflammatory Agents, Non-Steroidal Phase 3
6 Antirheumatic Agents Phase 3
7 Cyclooxygenase 2 Inhibitors Phase 3
8 Cyclooxygenase Inhibitors Phase 3
9 Peripheral Nervous System Agents Phase 3
10
Captopril Approved Phase 1 62571-86-2 44093
11
Carvedilol Approved, Investigational Phase 1 72956-09-3 2585
12
Spironolactone Approved Phase 1 1952-01-7, 52-01-7 5833
13 Adrenergic Agents Phase 1
14 Adrenergic alpha-1 Receptor Antagonists Phase 1
15 Adrenergic alpha-Antagonists Phase 1
16 Adrenergic Antagonists Phase 1
17 Adrenergic beta-Antagonists Phase 1
18 Angiotensin-Converting Enzyme Inhibitors Phase 1
19 Antihypertensive Agents Phase 1
20 diuretics Phase 1
21 Diuretics, Potassium Sparing Phase 1
22 HIV Protease Inhibitors Phase 1
23 Hormone Antagonists Phase 1
24 Hormones Phase 1
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
26 Mineralocorticoid Receptor Antagonists Phase 1
27 Mineralocorticoids Phase 1
28 Natriuretic Agents Phase 1
29 Neurotransmitter Agents Phase 1
30
protease inhibitors Phase 1
31 Vasodilator Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect Observation Study of COX-2 Inhibitor to Treat Primary Hypertrophic Osteoarthropathy Unknown status NCT02438709 Phase 3 COX-2 inhibitor
2 Spironolactone Combined With Captopril and Carvedilol for the Treatment of Pulmonary Arterial Hypertension Completed NCT00240656 Phase 1 spironolactone captopril carvedilol
3 Investigation of the Prevalence of Hepatopulmonary Syndrome in Cirrhosis Patients Caused by Hepatitis B in Western China Recruiting NCT03435406

Search NIH Clinical Center for Secondary Hypertrophic Osteoarthropathy

Cochrane evidence based reviews: osteoarthropathy, secondary hypertrophic

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Genetic Tests for Secondary Hypertrophic Osteoarthropathy

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Anatomical Context for Secondary Hypertrophic Osteoarthropathy

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MalaCards organs/tissues related to Secondary Hypertrophic Osteoarthropathy:

41
Bone, Lung, Cervix, Heart
Sources

Publications for Secondary Hypertrophic Osteoarthropathy

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Articles related to Secondary Hypertrophic Osteoarthropathy:

(show all 22)
# Title Authors Year
1
Sterile Bronchopleural Fistula Following Surgical Removal of Primary Lung Leiomyoma Inducing Secondary Hypertrophic Osteoarthropathy. ( 29519996 )
2018
2
Secondary Hypertrophic Osteoarthropathy Associated With Pediatric Primary Lung Squamous Cell Carcinoma. ( 29652703 )
2018
3
Secondary hypertrophic osteoarthropathy in a male from the Early Medieval settlement of Lauchheim, Germany. ( 29496219 )
2018
4
Secondary hypertrophic osteoarthropathy caused by non-pleural or pulmonary tumors. ( 28885355 )
2017
5
[Secondary hypertrophic osteoarthropathy to lung cancer: a case report]. ( 19547900 )
2009
6
Secondary hypertrophic osteoarthropathy on bone scintigraphy as a diagnosis of vascular prosthesis infection. ( 18392821 )
2008
7
Secondary hypertrophic osteoarthropathy: new insights on pathogenesis and management. ( 20084716 )
2007
8
Secondary hypertrophic osteoarthropathy associated with solitary fibrous tumor of the lung. ( 17938018 )
2007
9
Pierre Marie-Bamberger syndrome (secondary hypertrophic osteoarthropathy). ( 15663658 )
2005
10
Secondary hypertrophic osteoarthropathy (HOA) mimicking primary HOA (pachydermoperiostitis or Touraine-Solente-GolAc) syndrome. ( 14740519 )
2004
11
Secondary hypertrophic osteoarthropathy. ( 9542358 )
1998
12
Radiology case of the month. Digital clubbing, arthritis, and symmetric periostitis. Secondary hypertrophic osteoarthropathy (Marie-Bamberger syndrome). ( 8936939 )
1996
13
Pathogenesis of secondary hypertrophic osteoarthropathy: a hypothesis. ( 2703038 )
1989
14
Secondary hypertrophic osteoarthropathy in two children with humoral immunodeficiencies. ( 3372472 )
1988
15
Case report 126: secondary hypertrophic osteoarthropathy associated with excavating pulmonary metastases from squamous cell carcinoma of the cervix. ( 7209583 )
1980
16
Radionuclide demonstration of relative increased blood flow in uniappendicular secondary hypertrophic osteoarthropathy. ( 709981 )
1978
17
Delayed onset of secondary hypertrophic osteoarthropathy. ( 204179 )
1978
18
Secondary hypertrophic osteoarthropathy. An unusual cause of arthritis in childhood. ( 1067092 )
1976
19
Positive 99mTc-polyphosphate bone scan in a case of secondary hypertrophic osteoarthropathy. ( 4818305 )
1974
20
SECONDARY HYPERTROPHIC OSTEOARTHROPATHY AND ACANTHOSIS NIGRICANS. RESTUDY OF A CASE SIMULATING PACHYDERMOPERIOSTOSIS. ( 14096345 )
1964
21
Secondary hypertrophic osteoarthropathy. ( 13600644 )
1958
22
Secondary hypertrophic osteoarthropathy in congenital heart disease. ( 20255270 )
1947
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Variations for Secondary Hypertrophic Osteoarthropathy

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Expression for Secondary Hypertrophic Osteoarthropathy

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Search GEO for disease gene expression data for Secondary Hypertrophic Osteoarthropathy.
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Pathways for Secondary Hypertrophic Osteoarthropathy

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Pathways related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Phospholipase D signaling pathway 37
Show member pathways
 12.09 AVP HRAS KRAS
2
Signaling by FGFR2 66
Show member pathways
 11.87 GALNT3 HRAS KRAS
3
G alpha (s) signalling events 66
11.3 AVP CALCA POMC
4
Vemurafenib Pathway, Pharmacodynamics 61
11.16 HRAS KRAS
5
BDNF-TrkB Signaling 1
11.04 HRAS KRAS
6
Development_Leptin signaling via JAK/STAT and MAPK cascades 22
Show member pathways
 10.97 HRAS POMC
7
Extracellular vesicle-mediated signaling in recipient cells 1
10.95 HRAS KRAS
8
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities 1
10.93 HRAS KRAS
9
Bisphosphonate Pathway, Pharmacodynamics 61
Show member pathways
 10.9 HRAS KRAS
10
EGFR Transactivation by Gastrin 66
Show member pathways
 10.78 HRAS KRAS
11
MNAR-PELP1 and Estrogen Receptor Interaction 64
10.68 HRAS KRAS
12
CD209 (DC-SIGN) signaling 66
10.6 HRAS KRAS
13
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling 1
10.46 HRAS KRAS
14
p38MAPK events 66
9.74 HRAS KRAS
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GO Terms for Secondary Hypertrophic Osteoarthropathy

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Biological processes related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium-independent organic anion transport GO:0043252 9.26 AVP SLCO2A1
2 ERBB2 signaling pathway GO:0038128 9.16 HRAS KRAS
3 regulation of long-term neuronal synaptic plasticity GO:0048169 8.96 HRAS KRAS
4 response to isolation stress GO:0035900 8.62 HRAS KRAS

Molecular functions related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 8.96 AVP POMC
2 hormone activity GO:0005179 8.8 AVP CALCA POMC
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Sources for Secondary Hypertrophic Osteoarthropathy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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