MCID: SCN005
MIFTS: 38

Secondary Hypertrophic Osteoarthropathy

Categories: Bone diseases, Fetal diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases, Respiratory diseases, Skin diseases
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Aliases & Classifications for Secondary Hypertrophic Osteoarthropathy

MalaCards integrated aliases for Secondary Hypertrophic Osteoarthropathy:

Name: Secondary Hypertrophic Osteoarthropathy 11 14 16
Osteoarthropathy, Secondary Hypertrophic 43 71
Hpoa - Hypertrophic Pulmonary Osteoarthropathy 11
Hypertrophic Pulmonary Osteoarthropathy 11
Bamberger-Marie Disease 11
Marie Bamberger Disease 11

Classifications:



External Ids:

Disease Ontology 11 DOID:10393
ICD9CM 34 731.2
MeSH 43 D010005
SNOMED-CT 68 46922002
ICD10 31 M89.4
UMLS 71 C0029412

Summaries for Secondary Hypertrophic Osteoarthropathy

MalaCards based summary: Secondary Hypertrophic Osteoarthropathy, also known as osteoarthropathy, secondary hypertrophic, is related to hypertrophic osteoarthropathy, primary, autosomal recessive, 1 and acromegaloid changes, cutis verticis gyrata, and corneal leukoma, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Secondary Hypertrophic Osteoarthropathy is IGF2 (Insulin Like Growth Factor 2), and among its related pathways/superpathways are Signaling by Receptor Tyrosine Kinases and Development IGF-1 receptor signaling. The drugs Etoricoxib and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and cervix, and related phenotypes are homeostasis/metabolism and renal/urinary system

Related Diseases for Secondary Hypertrophic Osteoarthropathy

Diseases in the Primary Hypertrophic Osteoarthropathy family:

Hypertrophic Osteoarthropathy, Primary, Autosomal Dominant Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 2 Secondary Hypertrophic Osteoarthropathy

Diseases related to Secondary Hypertrophic Osteoarthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
# Related Disease Score Top Affiliating Genes
1 hypertrophic osteoarthropathy, primary, autosomal recessive, 1 32.1 SLCO2A1 HPGD
2 acromegaloid changes, cutis verticis gyrata, and corneal leukoma 30.6 SLCO2A1 HPGD
3 bronchus cancer 10.5
4 lung cancer 10.4
5 periostitis 10.4
6 lung cancer susceptibility 3 10.4
7 breast cancer 10.3
8 small cell cancer of the lung 10.3
9 gynecomastia 10.3
10 acroosteolysis 10.2 SLCO2A1 HPGD
11 cystic fibrosis 10.2
12 small cell carcinoma 10.2
13 alveolar echinococcosis 10.2
14 echinococcosis 10.2
15 arthropathy 10.2
16 osteoarthritis 10.2
17 bronchiectasis 10.2
18 paraneoplastic syndromes 10.2
19 primary hypertrophic osteoarthropathy 10.2 SLCO2A1 HPGD
20 lung benign neoplasm 10.2
21 neuroendocrine carcinoma 10.1
22 small intestine leiomyosarcoma 10.1 IGF2 CD34
23 nasal cavity benign neoplasm 10.1 NAB2 CD34
24 spindle cell thymoma 10.1 NAB2 CD34
25 pleural lipoma 10.1 SCARNA14 IGF2
26 smooth muscle tumor 10.1 IGF2 CD34
27 chordoid meningioma 10.1 NAB2 CD34
28 monophasic synovial sarcoma 10.1 NAB2 CD34
29 infantile myofibromatosis 10.1 NAB2 CD34
30 synovium cancer 10.0 NAB2 CD34
31 chronic congestive splenomegaly 10.0 SLC34A2 CD34
32 autoimmune disease 10.0
33 aortic valve disease 1 10.0
34 carcinoid tumors, intestinal 10.0
35 coarctation of aorta 10.0
36 renal cell carcinoma, nonpapillary 10.0
37 systemic lupus erythematosus 10.0
38 interstitial lung disease 2 10.0
39 factor vii deficiency 10.0
40 immune deficiency disease 10.0
41 pulmonary alveolar microlithiasis 10.0
42 pulmonary hypoplasia, primary 10.0
43 inflammatory bowel disease 1 10.0
44 systemic lupus erythematosus 1 10.0
45 tumor suppressor gene on chromosome 11 10.0
46 lymphoma, non-hodgkin, familial 10.0
47 aortic valve disease 2 10.0
48 aortic valve disease 3 10.0
49 infective endocarditis 10.0
50 bone disease 10.0

Graphical network of the top 20 diseases related to Secondary Hypertrophic Osteoarthropathy:



Diseases related to Secondary Hypertrophic Osteoarthropathy

Symptoms & Phenotypes for Secondary Hypertrophic Osteoarthropathy

UMLS symptoms related to Secondary Hypertrophic Osteoarthropathy:


arthralgia; metatarsalgia

MGI Mouse Phenotypes related to Secondary Hypertrophic Osteoarthropathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.76 CD34 HPGD IGF1 IGF2 NAB2 SLC34A2
2 renal/urinary system MP:0005367 9.65 IGF1 IGF2 SLC34A2 SLCO2A1 STAT6
3 cellular MP:0005384 9.5 CD34 HPGD IGF1 IGF2 NAB2 SLCO2A1
4 respiratory system MP:0005388 9.02 IGF1 IGF2 NAB2 SLC34A2 STAT6

Drugs & Therapeutics for Secondary Hypertrophic Osteoarthropathy

Drugs for Secondary Hypertrophic Osteoarthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoricoxib Approved, Investigational Phase 3 202409-33-4 123619
2 Analgesics Phase 3
3 Antirheumatic Agents Phase 3
4 Cyclooxygenase Inhibitors Phase 3
5 Cyclooxygenase 2 Inhibitors Phase 3
6 Anti-Inflammatory Agents, Non-Steroidal Phase 3
7 Analgesics, Non-Narcotic Phase 3
8 Anti-Inflammatory Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Application of COX-2 Inhibitor for Treatment of Primary Hypertrophic Osteoarthropathy Unknown status NCT02438709 Phase 3 COX-2 inhibitor

Search NIH Clinical Center for Secondary Hypertrophic Osteoarthropathy

Cochrane evidence based reviews: osteoarthropathy, secondary hypertrophic

Genetic Tests for Secondary Hypertrophic Osteoarthropathy

Anatomical Context for Secondary Hypertrophic Osteoarthropathy

Organs/tissues related to Secondary Hypertrophic Osteoarthropathy:

MalaCards : Bone, Lung, Cervix, Heart, Thymus, Breast, Pancreas

Publications for Secondary Hypertrophic Osteoarthropathy

Articles related to Secondary Hypertrophic Osteoarthropathy:

(show top 50) (show all 364)
# Title Authors PMID Year
1
Massive periostosis in a child from Neolithic Gebel es-Silsileh, Egypt. 62
36278913 2022
2
[Surgical Treatment for Lung Cancer Associated with Hypertrophic Pulmonary Osteoarthropathy]. 62
35474201 2022
3
Digital clubbing as first sign of giant solitary fibrous tumor. A case report. 62
34377434 2021
4
Chronic Joint Pain in a Young Adult With Cystic Fibrosis. 62
34540456 2021
5
Hypertrophic pulmonary osteoarthropathy with esophageal sarcomatoid carcinoma: a case report. 62
32954755 2021
6
Hypertrophic pulmonary osteoarthropathy: an unusual manifestation of lung cancer. 62
32170945 2020
7
Hypertrophic pulmonary osteoarthropathy due to lung cancer: A case report and literature review. 62
33363962 2020
8
Primary pulmonary lymphoepithelioma-like carcinoma accompanied by hypertrophic pulmonary osteoarthropathy in a non-epidemic region: a case report and literature review. 62
33161786 2020
9
Secondary Hypertrophic Osteoarthropathy in Pediatric Hodgkin lymphoma. 62
32686912 2020
10
Hypertrophic Pulmonary Osteoarthropathy Revealing a Solitary Fibrous Tumor. 62
32753128 2020
11
Recurrent hypertrophic pulmonary osteoarthropathy in an adult with bronchiectasis. 62
32587699 2020
12
Clinical Course of Hypertrophic Pulmonary Osteoarthropathy in a Patient Receiving Immune Checkpoint Inhibitor Therapy. 62
32067849 2020
13
Doege-Potter Syndrome and Pierre-Marie-Bamberger Syndrome in a Patient With Pleural Solitary Fibrous Tumor: A Rare Case With Literature Review. 62
32494533 2020
14
Sudden onset polyarthritis as a paraneoplastic syndrome from non-small cell lung cancer. 62
32850061 2020
15
The pleura and the endocrine system. 62
31918926 2020
16
Secondary Hypertrophic Osteoarthropathy Associated With Pediatric Primary Lung Squamous Cell Carcinoma. 62
29652703 2020
17
Pain control of hypertrophic pulmonary osteoarthropathy related with lung cancer: A clinical case report. 62
33501394 2019
18
Successful Treatment of ROS1-rearranged Lung Cancer Complicated by Hypertrophic Pulmonary Osteoarthropathy with Crizotinib Therapy. 62
30626830 2019
19
Pachydermoperiostosis (Touraine-Solente-Gole syndrome): a case report. 62
30786934 2019
20
Lung cancer, clubbing and hypertrophic pulmonary osteoarthropathy. 62
29878205 2018
21
A Case of Hypertrophic Pulmonary Osteoarthropathy in Both Upper and Lower Extremities: A Rare Involvement. 62
29889032 2018
22
[Paraneoplastic syndromes in rheumatology]. 62
29637254 2018
23
Pachydermoperiostosis in a patient with chronic hepatitis B virus infection referred as acromegaly: a case report. 62
29514715 2018
24
Secondary hypertrophic osteoarthropathy in a male from the Early Medieval settlement of Lauchheim, Germany. 62
29496219 2018
25
Sterile Bronchopleural Fistula Following Surgical Removal of Primary Lung Leiomyoma Inducing Secondary Hypertrophic Osteoarthropathy. 62
29519996 2018
26
Hypertrophic pulmonary osteoarthropathy: an unusual presentation. 62
31431958 2018
27
Secondary hypertrophic osteoarthropathy caused by non-pleural or pulmonary tumors. 62
28885355 2017
28
[Unusual association of two paraneoplastic syndromes in lung adenocarcinoma: Acquired ichtyosis and hypertrophic pulmonary osteoarthropathy]. 62
28756889 2017
29
Voriconazole-Induced Periostitis Deformans: A Mimicker of Hypertrophic Pulmonary Osteoarthropathy. 62
28487449 2017
30
Graft Infection Masquerading as Rheumatologic Disease: a Rare Case of Aortobifemoral Graft Infection Presenting as Hypertrophic Osteoarthropathy. 62
28279724 2017
31
Impact of hypertrophic pulmonary osteoarthropathy on patients with lung cancer. 62
29123415 2017
32
Hypertrophic Osteoarthropathy: Clinical and Imaging Features. 62
27935768 2017
33
[Secondary hypertrophic osteoarthropathy (HOA) or Pierre-Marie Bamberger syndrome revealing bronchial adenocarcinoma]. 62
28819538 2017
34
Laxative Related Primary Hyperphosphatemic Tumoral Calcinosis Identified by Bone Scintigraphy. 62
27651742 2016
35
Cutaneous manifestations of lung cancer. 62
27178690 2016
36
Blepharoptosis and hypertrophic osteoarthropathy: A case report. 62
27221686 2016
37
Anti-inflammatory drugs and analgesics for managing symptoms in people with cystic fibrosis-related arthritis. 62
26798057 2016
38
[If digital clubbing appears bear Marie-Bamberger disease in mind]. 62
26450436 2015
39
The seminal role played by Pierre Marie in Neurology and Internal Medicine. 62
26331384 2015
40
Hypertrophic Pulmonary Osteoarthropathy: A Rare But Treatable Condition in Palliative Medicine. 62
25701054 2015
41
Hypertrophic pulmonary osteoarthropathy on bone scintigraphy and 18F-fluorodeoxyglucose positron emission tomography/computed tomography in a patient with lung adenocarcinoma. 62
26170569 2015
42
Imaging observations of pulmonary inflammatory myofibroblastic tumors in patients over 40 years old. 62
25789060 2015
43
An Unusual Mimicker of Systemic Lupus Erythematosus: A Case Report. 62
26106457 2015
44
Hypertrophic Pulmonary Osteoarthropathy in Anaplastic Lymphoma Kinase (ALK)-positive Lung Cancer. 62
26278300 2015
45
Non-traumatic calcifications/ossifications of the bone surface and soft tissues of the wrist, hand and fingers: a diagnostic approach. 62
25224813 2014
46
Hypertrophic pulmonary osteoarthropathy with primary lung cancer. 62
24932292 2014
47
18F-Fluoride bone positron emission tomography demonstrating changes related to finger clubbing and hypertrophic osteoarthropathy. 62
24761070 2014
48
Hypertrophic pulmonary osteoarthropathy in a patient with lung cancer. 62
25447667 2014
49
Hypertrophic osteoarthropathy and congenital heart disease: this is not casual. 62
24049086 2013
50
[Bronchial carcinoma and knee pain. Secondary hypertrophic osteoarthropathy]. 62
23052705 2013

Variations for Secondary Hypertrophic Osteoarthropathy

Expression for Secondary Hypertrophic Osteoarthropathy

Search GEO for disease gene expression data for Secondary Hypertrophic Osteoarthropathy.

Pathways for Secondary Hypertrophic Osteoarthropathy

Pathways related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.64 STAT6 NAB2 IGF2 IGF1
2
Show member pathways
11.4 STAT6 IGF2 IGF1
3 11.11 IGF2 IGF1
4 10.99 IGF1 CD34
5 10.88 IGF2 IGF1

GO Terms for Secondary Hypertrophic Osteoarthropathy

Biological processes related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of mitotic nuclear division GO:0045840 9.56 IGF2 IGF1
2 positive regulation of activated T cell proliferation GO:0042104 9.46 IGF2 IGF1
3 insulin-like growth factor receptor signaling pathway GO:0048009 9.13 IGF2 IGF1
4 positive regulation of glycogen biosynthetic process GO:0045725 8.92 IGF2 IGF1

Molecular functions related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.26 IGF2 IGF1
2 insulin-like growth factor receptor binding GO:0005159 8.92 IGF2 IGF1

Sources for Secondary Hypertrophic Osteoarthropathy

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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