Secondary Hypertrophic Osteoarthropathy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Secondary Hypertrophic Osteoarthropathy, also known as osteoarthropathy, secondary hypertrophic, is related to hypertrophic osteoarthropathy, primary, autosomal recessive, 1 and acromegaloid changes, cutis verticis gyrata, and corneal leukoma, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Secondary Hypertrophic Osteoarthropathy is IGF2 (Insulin Like Growth Factor 2), and among its related pathways/superpathways are Signaling by Receptor Tyrosine Kinases and Development IGF-1 receptor signaling. The drugs Etoricoxib and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and cervix, and related phenotypes are homeostasis/metabolism and renal/urinary system

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Related Diseases for Secondary Hypertrophic Osteoarthropathy

Diseases in the Primary Hypertrophic Osteoarthropathy family:

Hypertrophic Osteoarthropathy, Primary, Autosomal Dominant	Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 2	Secondary Hypertrophic Osteoarthropathy

Diseases related to Secondary Hypertrophic Osteoarthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)

#	Related Disease	Score	Top Affiliating Genes
1	hypertrophic osteoarthropathy, primary, autosomal recessive, 1	32.1	SLCO2A1 HPGD
2	acromegaloid changes, cutis verticis gyrata, and corneal leukoma	30.6	SLCO2A1 HPGD
3	bronchus cancer	10.5
4	lung cancer	10.4
5	periostitis	10.4
6	lung cancer susceptibility 3	10.4
7	breast cancer	10.3
8	small cell cancer of the lung	10.3
9	gynecomastia	10.3
10	acroosteolysis	10.2	SLCO2A1 HPGD
11	cystic fibrosis	10.2
12	small cell carcinoma	10.2
13	alveolar echinococcosis	10.2
14	echinococcosis	10.2
15	arthropathy	10.2
16	osteoarthritis	10.2
17	bronchiectasis	10.2
18	paraneoplastic syndromes	10.2
19	primary hypertrophic osteoarthropathy	10.2	SLCO2A1 HPGD
20	lung benign neoplasm	10.2
21	neuroendocrine carcinoma	10.1
22	small intestine leiomyosarcoma	10.1	IGF2 CD34
23	nasal cavity benign neoplasm	10.1	NAB2 CD34
24	spindle cell thymoma	10.1	NAB2 CD34
25	pleural lipoma	10.1	SCARNA14 IGF2
26	smooth muscle tumor	10.1	IGF2 CD34
27	chordoid meningioma	10.1	NAB2 CD34
28	monophasic synovial sarcoma	10.1	NAB2 CD34
29	infantile myofibromatosis	10.1	NAB2 CD34
30	synovium cancer	10.0	NAB2 CD34
31	chronic congestive splenomegaly	10.0	SLC34A2 CD34
32	autoimmune disease	10.0
33	aortic valve disease 1	10.0
34	carcinoid tumors, intestinal	10.0
35	coarctation of aorta	10.0
36	renal cell carcinoma, nonpapillary	10.0
37	systemic lupus erythematosus	10.0
38	interstitial lung disease 2	10.0
39	factor vii deficiency	10.0
40	immune deficiency disease	10.0
41	pulmonary alveolar microlithiasis	10.0
42	pulmonary hypoplasia, primary	10.0
43	inflammatory bowel disease 1	10.0
44	systemic lupus erythematosus 1	10.0
45	tumor suppressor gene on chromosome 11	10.0
46	lymphoma, non-hodgkin, familial	10.0
47	aortic valve disease 2	10.0
48	aortic valve disease 3	10.0
49	infective endocarditis	10.0
50	bone disease	10.0

Graphical network of the top 20 diseases related to Secondary Hypertrophic Osteoarthropathy:

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Symptoms & Phenotypes for Secondary Hypertrophic Osteoarthropathy

UMLS symptoms related to Secondary Hypertrophic Osteoarthropathy:

arthralgia; metatarsalgia

MGI Mouse Phenotypes related to Secondary Hypertrophic Osteoarthropathy:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.76	CD34 HPGD IGF1 IGF2 NAB2 SLC34A2
2	renal/urinary system	MP:0005367	9.65	IGF1 IGF2 SLC34A2 SLCO2A1 STAT6
3	cellular	MP:0005384	9.5	CD34 HPGD IGF1 IGF2 NAB2 SLCO2A1
4	respiratory system	MP:0005388	9.02	IGF1 IGF2 NAB2 SLC34A2 STAT6

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Drugs & Therapeutics for Secondary Hypertrophic Osteoarthropathy

Drugs for Secondary Hypertrophic Osteoarthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Etoricoxib

Approved, Investigational

Phase 3

202409-33-4

123619

2

Analgesics

Phase 3

3

Antirheumatic Agents

Phase 3

4

Cyclooxygenase Inhibitors

Phase 3

5

Cyclooxygenase 2 Inhibitors

Phase 3

6

Anti-Inflammatory Agents, Non-Steroidal

Phase 3

7

Analgesics, Non-Narcotic

Phase 3

8

Anti-Inflammatory Agents

Phase 3

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Application of COX-2 Inhibitor for Treatment of Primary Hypertrophic Osteoarthropathy	Unknown status	NCT02438709	Phase 3	COX-2 inhibitor

Search NIH Clinical Center for Secondary Hypertrophic Osteoarthropathy

Cochrane evidence based reviews: osteoarthropathy, secondary hypertrophic

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Genetic Tests for Secondary Hypertrophic Osteoarthropathy

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Anatomical Context for Secondary Hypertrophic Osteoarthropathy

Organs/tissues related to Secondary Hypertrophic Osteoarthropathy:

MalaCards : Bone, Lung, Cervix, Heart, Thymus, Breast, Pancreas

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Publications for Secondary Hypertrophic Osteoarthropathy

Articles related to Secondary Hypertrophic Osteoarthropathy:

(show top 50) (show all 364)

#	Title	Authors	PMID	Year
1	Massive periostosis in a child from Neolithic Gebel es-Silsileh, Egypt. ⁶²	Gresky J...Schultz M	36278913	2022
2	[Surgical Treatment for Lung Cancer Associated with Hypertrophic Pulmonary Osteoarthropathy]. ⁶²	Fujita T...Satou N	35474201	2022
3	Digital clubbing as first sign of giant solitary fibrous tumor. A case report. ⁶²	Mejias-Lafontaine E...Gonzalez-Cancel I	34377434	2021
4	Chronic Joint Pain in a Young Adult With Cystic Fibrosis. ⁶²	Prajapati BB...Sears EH	34540456	2021
5	Hypertrophic pulmonary osteoarthropathy with esophageal sarcomatoid carcinoma: a case report. ⁶²	Zhao M...Hui Z	32954755	2021
6	Hypertrophic pulmonary osteoarthropathy: an unusual manifestation of lung cancer. ⁶²	Sugimoto H...Nakata K	32170945	2020
7	Hypertrophic pulmonary osteoarthropathy due to lung cancer: A case report and literature review. ⁶²	Shinzato A...Fujita J	33363962	2020
8	Primary pulmonary lymphoepithelioma-like carcinoma accompanied by hypertrophic pulmonary osteoarthropathy in a non-epidemic region: a case report and literature review. ⁶²	Zhu N...Cao C	33161786	2020
9	Secondary Hypertrophic Osteoarthropathy in Pediatric Hodgkin lymphoma. ⁶²	Tam HHY...Laxer RM	32686912	2020
10	Hypertrophic Pulmonary Osteoarthropathy Revealing a Solitary Fibrous Tumor. ⁶²	Auroux M...Adelaide L	32753128	2020
11	Recurrent hypertrophic pulmonary osteoarthropathy in an adult with bronchiectasis. ⁶²	Tekiteki A...Wong CA	32587699	2020
12	Clinical Course of Hypertrophic Pulmonary Osteoarthropathy in a Patient Receiving Immune Checkpoint Inhibitor Therapy. ⁶²	Johns AC...Owen DH	32067849	2020
13	Doege-Potter Syndrome and Pierre-Marie-Bamberger Syndrome in a Patient With Pleural Solitary Fibrous Tumor: A Rare Case With Literature Review. ⁶²	Solsi A...Noori T	32494533	2020
14	Sudden onset polyarthritis as a paraneoplastic syndrome from non-small cell lung cancer. ⁶²	Poddar K...Villamil M	32850061	2020
15	The pleura and the endocrine system. ⁶²	Sorino C...Feller-Kopman D	31918926	2020
16	Secondary Hypertrophic Osteoarthropathy Associated With Pediatric Primary Lung Squamous Cell Carcinoma. ⁶²	Cao C...Shenoi S	29652703	2020
17	Pain control of hypertrophic pulmonary osteoarthropathy related with lung cancer: A clinical case report. ⁶²	Alves S...Soares M	33501394	2019
18	Successful Treatment of ROS1-rearranged Lung Cancer Complicated by Hypertrophic Pulmonary Osteoarthropathy with Crizotinib Therapy. ⁶²	Katsurada N...Nishimura Y	30626830	2019
19	Pachydermoperiostosis (Touraine-Solente-Gole syndrome): a case report. ⁶²	Joshi A...Baral S	30786934	2019
20	Lung cancer, clubbing and hypertrophic pulmonary osteoarthropathy. ⁶²	Mondal S...Ghosh A	29878205	2018
21	A Case of Hypertrophic Pulmonary Osteoarthropathy in Both Upper and Lower Extremities: A Rare Involvement. ⁶²	Okudan B...Naldoken S	29889032	2018
22	[Paraneoplastic syndromes in rheumatology]. ⁶²	Schmalzing M	29637254	2018
23	Pachydermoperiostosis in a patient with chronic hepatitis B virus infection referred as acromegaly: a case report. ⁶²	Atiase Y...Akpalu A	29514715	2018
24	Secondary hypertrophic osteoarthropathy in a male from the Early Medieval settlement of Lauchheim, Germany. ⁶²	Flohr S...Wahl J	29496219	2018
25	Sterile Bronchopleural Fistula Following Surgical Removal of Primary Lung Leiomyoma Inducing Secondary Hypertrophic Osteoarthropathy. ⁶²	AlAmodi AA...AlShammari A	29519996	2018
26	Hypertrophic pulmonary osteoarthropathy: an unusual presentation. ⁶²	Kumari P...Kiani AN	31431958	2018
27	Secondary hypertrophic osteoarthropathy caused by non-pleural or pulmonary tumors. ⁶²	Meyer HJ...Surov A	28885355	2017
28	[Unusual association of two paraneoplastic syndromes in lung adenocarcinoma: Acquired ichtyosis and hypertrophic pulmonary osteoarthropathy]. ⁶²	Bacha S...Chabbou A	28756889	2017
29	Voriconazole-Induced Periostitis Deformans: A Mimicker of Hypertrophic Pulmonary Osteoarthropathy. ⁶²	Ladak K...Rubin L	28487449	2017
30	Graft Infection Masquerading as Rheumatologic Disease: a Rare Case of Aortobifemoral Graft Infection Presenting as Hypertrophic Osteoarthropathy. ⁶²	Chapman SA...Jameson AP	28279724	2017
31	Impact of hypertrophic pulmonary osteoarthropathy on patients with lung cancer. ⁶²	Fang YH...Lin YC	29123415	2017
32	Hypertrophic Osteoarthropathy: Clinical and Imaging Features. ⁶²	Yap FY...Matcuk GR	27935768	2017
33	[Secondary hypertrophic osteoarthropathy (HOA) or Pierre-Marie Bamberger syndrome revealing bronchial adenocarcinoma]. ⁶²	El M'rabet FZ...Ouahbi H	28819538	2017
34	Laxative Related Primary Hyperphosphatemic Tumoral Calcinosis Identified by Bone Scintigraphy. ⁶²	Asokendaran M...Lenzo NP	27651742	2016
35	Cutaneous manifestations of lung cancer. ⁶²	Owen CE	27178690	2016
36	Blepharoptosis and hypertrophic osteoarthropathy: A case report. ⁶²	Dogan AS...Dikmetas O	27221686	2016
37	Anti-inflammatory drugs and analgesics for managing symptoms in people with cystic fibrosis-related arthritis. ⁶²	Thornton J...Rangaraj S	26798057	2016
38	[If digital clubbing appears bear Marie-Bamberger disease in mind]. ⁶²	Hartig I...Braun MG	26450436	2015
39	The seminal role played by Pierre Marie in Neurology and Internal Medicine. ⁶²	Almeida GM...Teive HA	26331384	2015
40	Hypertrophic Pulmonary Osteoarthropathy: A Rare But Treatable Condition in Palliative Medicine. ⁶²	Pourmorteza M...Da Silva MA	25701054	2015
41	Hypertrophic pulmonary osteoarthropathy on bone scintigraphy and 18F-fluorodeoxyglucose positron emission tomography/computed tomography in a patient with lung adenocarcinoma. ⁶²	Cengiz A...Yurekli Y	26170569	2015
42	Imaging observations of pulmonary inflammatory myofibroblastic tumors in patients over 40 years old. ⁶²	Wu J...Lu GM	25789060	2015
43	An Unusual Mimicker of Systemic Lupus Erythematosus: A Case Report. ⁶²	Aluoch AO...Gladue H	26106457	2015
44	Hypertrophic Pulmonary Osteoarthropathy in Anaplastic Lymphoma Kinase (ALK)-positive Lung Cancer. ⁶²	Komatsu M...Ichikawa K	26278300	2015
45	Non-traumatic calcifications/ossifications of the bone surface and soft tissues of the wrist, hand and fingers: a diagnostic approach. ⁶²	Touraine S...Laredo JD	25224813	2014
46	Hypertrophic pulmonary osteoarthropathy with primary lung cancer. ⁶²	Qian X...Qin J	24932292	2014
47	18F-Fluoride bone positron emission tomography demonstrating changes related to finger clubbing and hypertrophic osteoarthropathy. ⁶²	Kashyap R...Muntimadugu B	24761070	2014
48	Hypertrophic pulmonary osteoarthropathy in a patient with lung cancer. ⁶²	Tsai MY...Wu FZ	25447667	2014
49	Hypertrophic osteoarthropathy and congenital heart disease: this is not casual. ⁶²	Ferreira E...Camoes I	24049086	2013
50	[Bronchial carcinoma and knee pain. Secondary hypertrophic osteoarthropathy]. ⁶²	Baranowski A...Hansen M	23052705	2013

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Genes for Secondary Hypertrophic Osteoarthropathy

Genes related to Secondary Hypertrophic Osteoarthropathy (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IGF2	Insulin Like Growth Factor 2	Protein Coding	6.11	DISEASES inferred ¹⁴
2	SLCO2A1	Solute Carrier Organic Anion Transporter Family Member 2A1	Protein Coding	6.03	DISEASES inferred ¹⁴
3	HPGD	15-Hydroxyprostaglandin Dehydrogenase	Protein Coding	5.85	DISEASES inferred ¹⁴
4	NAB2	NGFI-A Binding Protein 2	Protein Coding	5.66	DISEASES inferred ¹⁴
5	CD34	CD34 Molecule	Protein Coding	5.12	DISEASES inferred ¹⁴
6	SLC34A2	Solute Carrier Family 34 Member 2	Protein Coding	4.98	DISEASES inferred ¹⁴
7	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	4.69	DISEASES inferred ¹⁴
8	IGF1	Insulin Like Growth Factor 1	Protein Coding	4.66	DISEASES inferred ¹⁴
9	SCARNA14	Small Cajal Body-Specific RNA 14	RNA Gene	4.62	DISEASES inferred ¹⁴

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Variations for Secondary Hypertrophic Osteoarthropathy

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Expression for Secondary Hypertrophic Osteoarthropathy

Search GEO for disease gene expression data for Secondary Hypertrophic Osteoarthropathy.

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Pathways for Secondary Hypertrophic Osteoarthropathy

Pathways related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by Receptor Tyrosine Kinases ⁶⁶	11.64	STAT6 NAB2 IGF2 IGF1
2	Development IGF-1 receptor signaling ²² Show member pathways Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	11.4	STAT6 IGF2 IGF1
3	Cell adhesion_ECM remodeling ²²	11.11	IGF2 IGF1
4	Hair follicle development: cytodifferentiation - part 3 of 3 ⁷⁴	10.99	IGF1 CD34
5	Cardiac progenitor differentiation ⁷⁴	10.88	IGF2 IGF1

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GO Terms for Secondary Hypertrophic Osteoarthropathy

Biological processes related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of mitotic nuclear division	GO:0045840	9.56	IGF2 IGF1
2	positive regulation of activated T cell proliferation	GO:0042104	9.46	IGF2 IGF1
3	insulin-like growth factor receptor signaling pathway	GO:0048009	9.13	IGF2 IGF1
4	positive regulation of glycogen biosynthetic process	GO:0045725	8.92	IGF2 IGF1

Molecular functions related to Secondary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	insulin receptor binding	GO:0005158	9.26	IGF2 IGF1
2	insulin-like growth factor receptor binding	GO:0005159	8.92	IGF2 IGF1

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Sources for Secondary Hypertrophic Osteoarthropathy

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: SCN005 MIFTS: 38	Secondary Hypertrophic Osteoarthropathy Categories: Bone diseases, Fetal diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases, Respiratory diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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