MCID: SCN059
MIFTS: 22

Secondary Sclerosing Cholangitis

Categories: Gastrointestinal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Secondary Sclerosing Cholangitis

MalaCards integrated aliases for Secondary Sclerosing Cholangitis:

Name: Secondary Sclerosing Cholangitis 58 70

Characteristics:

Orphanet epidemiological data:

58
secondary sclerosing cholangitis
Inheritance: Not applicable;

Classifications:

Orphanet: 58  
Rare hepatic diseases


External Ids:

ICD10 via Orphanet 33 K83.0
Orphanet 58 ORPHA447774
UMLS 70 C0400978

Summaries for Secondary Sclerosing Cholangitis

MalaCards based summary : Secondary Sclerosing Cholangitis is related to bile duct cancer and sclerosing cholangitis. An important gene associated with Secondary Sclerosing Cholangitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2). Affiliated tissues include liver, pancreas and lung.

Wikipedia : 73 Secondary sclerosing cholangitis (SSC) is a chronic cholestatic liver disease. SSC is a sclerosing... more...

Related Diseases for Secondary Sclerosing Cholangitis

Diseases in the Sclerosing Cholangitis family:

Cholangitis, Primary Sclerosing Secondary Sclerosing Cholangitis

Diseases related to Secondary Sclerosing Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 bile duct cancer 11.3
2 sclerosing cholangitis 10.9
3 cholangitis 10.9
4 cholestasis 10.6
5 cholangitis, primary sclerosing 10.5
6 liver cirrhosis 10.4
7 liver disease 10.3
8 cholangiocarcinoma 10.2
9 intrahepatic cholangiocarcinoma 10.2
10 hemolytic-uremic syndrome 10.1
11 cholecystitis 10.1
12 hypercholesterolemia, familial, 1 10.0
13 small cell cancer of the lung 10.0
14 lung cancer 10.0
15 enterocolitis 10.0
16 hemochromatosis, type 1 10.0
17 immune deficiency disease 10.0
18 immunodeficiency with hyper-igm, type 1 10.0
19 gallbladder disease 1 10.0
20 light fixation seizure syndrome 10.0
21 mycobacterium tuberculosis 1 10.0
22 lung cancer susceptibility 3 10.0
23 microvascular complications of diabetes 3 10.0
24 microvascular complications of diabetes 4 10.0
25 microvascular complications of diabetes 6 10.0
26 microvascular complications of diabetes 7 10.0
27 anaplastic large cell lymphoma 10.0
28 cd40 ligand deficiency 10.0
29 lymphoma 10.0
30 ischemic colitis 10.0
31 intrahepatic cholestasis of pregnancy 10.0
32 portal hypertension 10.0
33 adult respiratory distress syndrome 10.0
34 choledocholithiasis 10.0
35 hepatic coma 10.0
36 diarrhea 10.0
37 hepatic encephalopathy 10.0
38 obstructive jaundice 10.0
39 alcoholic liver cirrhosis 10.0
40 suppurative cholangitis 10.0
41 cryptosporidiosis 10.0
42 acalculous cholecystitis 10.0
43 acute pancreatitis 10.0
44 severe acute respiratory syndrome 10.0
45 adenocarcinoma 10.0
46 acute kidney failure 10.0
47 gallbladder adenocarcinoma 10.0
48 acquired immunodeficiency syndrome 10.0
49 influenza 10.0
50 liver lymphoma 10.0

Graphical network of the top 20 diseases related to Secondary Sclerosing Cholangitis:



Diseases related to Secondary Sclerosing Cholangitis

Symptoms & Phenotypes for Secondary Sclerosing Cholangitis

Drugs & Therapeutics for Secondary Sclerosing Cholangitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Secondary Sclerosing Cholangitis in Critically Ill Patients (SSC-CIP): A Pilot Study on the Possible Genetic Basis of the Disease Recruiting NCT02545309
2 Secondary Sclerosing Cholangitis in Critically Ill Patients (SC-CIP): A Prospective Cohort Study Recruiting NCT03566797

Search NIH Clinical Center for Secondary Sclerosing Cholangitis

Genetic Tests for Secondary Sclerosing Cholangitis

Anatomical Context for Secondary Sclerosing Cholangitis

MalaCards organs/tissues related to Secondary Sclerosing Cholangitis:

40
Liver, Pancreas, Lung, Kidney

Publications for Secondary Sclerosing Cholangitis

Articles related to Secondary Sclerosing Cholangitis:

(show top 50) (show all 195)
# Title Authors PMID Year
1
The Gut-Liver Axis in Cholestatic Liver Diseases. 61
33801133 2021
2
Fibrates for Itch (FITCH) in Fibrosing Cholangiopathies: A Double-Blind, Randomized, Placebo-Controlled Trial. 61
33031833 2021
3
A case with life-threatening secondary sclerosing cholangitis caused by nivolumab. 61
33200345 2021
4
Post-COVID-19 Cholangiopathy: A Novel Entity. 61
33464757 2021
5
Atezolizumab-induced Sclerosing Cholangitis in a patient with lung cancer: A case report. 61
33338849 2021
6
Liver Transplantation for Langerhans Cell Histiocytosis: A U.S. Population-Based Analysis and Systematic Review of the Literature. 61
33484600 2021
7
Ketamine-Induced Sclerosing Cholangitis (KISC) in a Critically Ill Patient with COVID-19. 61
33226658 2020
8
Secondary sclerosing cholangitis in critically ill patients: a rare disease precipitated by severe SARS-CoV-2 infection. 61
33168538 2020
9
[Hepatic dysfunction in sepsis]. 61
32725325 2020
10
Secondary Sclerosing Cholangitis in Critically Ill Patients Alters the Gut-Liver Axis: A Case Control Study. 61
32906634 2020
11
Secondary sclerosing cholangitis in critically ill patients has a poor outcome but lower tumour incidence than primary sclerosing cholangitis. 61
32366182 2020
12
Pembrolizumab-induced secondary sclerosing cholangitis in a non-small cell lung cancer patient. 61
32284868 2020
13
Extrahepatic biliary duplication with heterotopic gastric mucosa in a 46,XX male patient. 61
32179063 2020
14
Liver Dysfunction in Sepsis. 61
32326684 2020
15
Pathologic Manifestations of Gastrointestinal and Hepatobiliary Injury in Immune Checkpoint Inhibitor Therapy. 61
32338534 2020
16
Secondary Sclerosing Cholangitis in Critically Ill Patients: An Underdiagnosed Entity. 61
32266307 2020
17
Intrahepatic biliary strictures after liver transplantation are morphologically similar to primary sclerosing cholangitis but immunologically distinct. 61
31895887 2020
18
Challenging biliary strictures: pathophysiological features, differential diagnosis, diagnostic algorithms, and new clinically relevant biomarkers - part 1. 61
32595761 2020
19
An Interprofessional Approach in Caring for a Patient on Maintenance Hemodialysis with COVID-19 in Toronto, Canada: An Educational Case Report. 61
32953129 2020
20
[Hepatic dysfunction in patients with cardiogenic shock]. 61
31538212 2019
21
Nivolumab-Induced Secondary Sclerosing Cholangitis with Deterioration Despite Immunosuppression. 61
31445738 2019
22
Contributing factors and outcomes of burn-associated cholestasis. 61
31152758 2019
23
Low-Phospholipid Associated Cholelithiasis (LPAC) syndrome: A synthetic review. 61
30922600 2019
24
Secondary sclerosing cholangitis with hemobilia induced by pembrolizumab: Case report and review of published work. 61
30861263 2019
25
Chemotherapy-Induced Sclerosing Cholangitis Caused by Systemic Chemotherapy. 61
31620533 2019
26
A Case of Secondary Sclerosing Cholangitis in the setting of Non-Hodgkin's Lymphoma. 61
31355067 2019
27
Radiological patterns of secondary sclerosing cholangitis in patients after lung transplantation. 61
30377725 2019
28
Antiprogrammed Cell Death-1 Immunotherapy-Related Secondary Sclerosing Cholangitis. 61
30033637 2019
29
Sclerosing Cholangitis Related to IgG4: Not Always a Curable Entity. 61
31113593 2019
30
Secondary sclerosing cholangitis in critically ill patients. 61
30951033 2019
31
Secondary sclerosing cholangitis in critically ill patients after a traffic accident-a new entity that should be considered in death classification. 61
29484493 2018
32
Infant onset severe complement-mediated hemolytic uremic syndrome complicated by secondary sclerosing cholangitis. 61
30168181 2018
33
Secondary sclerosing cholangitis following extracorporeal membrane oxygenation for acute respiratory distress in polytrauma. 61
30214777 2018
34
[IgG4-associated cholangitis - clinical presentation of an overlooked disease entity]. 61
29767269 2018
35
IgG4-Related Cholangiopathy and Its Mimickers: A Case Report and Review Highlighting the Importance of Early Diagnosis. 61
28905689 2018
36
Secondary sclerosing cholangitis in critically ill patients. 61
29681633 2018
37
Secondary sclerosing cholangitis in localized hepatobiliary tuberculosis simulating cholangiocarcinoma: a rare case report. 61
29179696 2017
38
Drug-induced cholestasis. 61
29404489 2017
39
Pregnant Lady With Undiagnosed Hodgkin's Disease Presenting As Secondary Sclerosing Cholangitis. 61
29331005 2017
40
Secondary sclerosing cholangitis in cardiac surgical patients: A complication with a dismal prognosis. 61
28554673 2017
41
Secondary Sclerosing Cholangitis: a Review of Recent Literature. 61
28752474 2017
42
Secondary sclerosing cholangitis following cardiac surgery: An uncommon but deadly gastrointestinal complication. 61
28625770 2017
43
NOD2 gene variants confer risk for secondary sclerosing cholangitis in critically ill patients. 61
28765628 2017
44
Very Severe Secondary Sclerosing Cholangitis as a Sequela of Influenza. 61
28683859 2017
45
Fibrates for the treatment of cholestatic itch (FITCH): study protocol for a randomized controlled trial. 61
28535810 2017
46
Secondary Sclerosing Cholangitis From Spontaneous Choledochoduodenal Fistula. 61
27670380 2017
47
Prophylaxis of post-ERC infectious complications in patients with biliary obstruction by adding antimicrobial agents into ERC contrast media- a single center retrospective study. 61
28086796 2017
48
Secondary sclerosing cholangitis in critically ill patients: current perspectives. 61
28694703 2017
49
Liver - guardian, modifier and target of sepsis. 61
27924081 2017
50
Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis. 61
27406039 2017

Variations for Secondary Sclerosing Cholangitis

Expression for Secondary Sclerosing Cholangitis

Search GEO for disease gene expression data for Secondary Sclerosing Cholangitis.

Pathways for Secondary Sclerosing Cholangitis

GO Terms for Secondary Sclerosing Cholangitis

Sources for Secondary Sclerosing Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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