MCID: SCN006
MIFTS: 37

Secondary Syphilis

Categories: Bone diseases, Fetal diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases
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Aliases & Classifications for Secondary Syphilis

MalaCards integrated aliases for Secondary Syphilis:

Name: Secondary Syphilis 11 14
Syphilis, Secondary 43 71
Secondary Syphilis of Viscera or Bone 11

Classifications:



External Ids:

Disease Ontology 11 DOID:4157
ICD9CM 34 091.9
MeSH 43 C536773
NCIt 49 C128413
SNOMED-CT 68 154382002
UMLS 71 C0149985

Summaries for Secondary Syphilis

Disease Ontology: 11 A syphilis that is characterized as the second stage of syphilis which appears from 2 to 6 months after primary infection, and is marked by lesions especially in the skin but also in organs and tissues, and that lasts from 3 to 12 weeks.

MalaCards based summary: Secondary Syphilis, also known as syphilis, secondary, is related to asymptomatic neurosyphilis and congenital syphilis. An important gene associated with Secondary Syphilis is TPR (Translocated Promoter Region, Nuclear Basket Protein), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and IL12-mediated signaling events. The drugs Linezolid and Antibiotics, Antitubercular have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and liver.

Related Diseases for Secondary Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Secondary Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 776)
# Related Disease Score Top Affiliating Genes
1 asymptomatic neurosyphilis 32.0 CXCL13 CD4
2 congenital syphilis 31.6 TPR POLA1 EPB41L3 CRP CD4
3 syphilis 30.7 TPR TNF GPT CRP CD8A CD4
4 pityriasis rosea 30.6 CD8A CD4
5 leprosy 3 30.5 TNF CD8A CD4
6 yaws 30.4 TPR POLA1 EPB41L3
7 bone inflammation disease 30.3 TNF CRP CD8A CD4
8 primary syphilis 30.3 TPR POLA1 MIR589 EPB41L3 CD8A CD4
9 angular cheilitis 30.3 TNF CD4
10 fungal infectious disease 30.3 TNF CRP CD8A CD4
11 syphilitic meningitis 30.3 CXCL13 CRP CD4
12 aortitis 30.2 TNF CRP CD4
13 acquired immunodeficiency syndrome 30.2 TNF CRP CD4 CCR5
14 tenosynovitis 30.2 TNF CRP CD8A CD4
15 meningitis 30.1 TNF CXCL13 CRP
16 oral hairy leukoplakia 30.1 CD8A CD4
17 chlamydia 30.1 TNF CRP CCR5
18 lepromatous leprosy 30.1 TNF CD8A CD4
19 exanthem 30.1 TNF GPT CRP CD8A CD4 ACE
20 optic papillitis 30.1 TNF CRP CD4 ACE
21 glomerulonephritis 30.0 TNF CRP CCR5 ACE
22 early yaws 30.0 TPR CD8A CD4
23 neuroretinitis 30.0 CRP CD4 ACE
24 granuloma annulare 30.0 TNF CD8A CD4 ACE
25 optic neuritis 30.0 TNF CXCL13 CCR5
26 tertiary syphilis 30.0 TPR TNF CXCL13 CRP CD8A CD4
27 parotitis 30.0 CRP CD8A CD4
28 sapho syndrome 29.9 TNF CRP
29 anterior uveitis 29.9 TNF CRP CD8A CD4 ACE
30 latent syphilis 29.9 TPR POLA1 MIR589 CXCL13 CD4
31 posterior uveitis 29.9 TNF CD4 ACE
32 chorioretinitis 29.9 TNF CRP CD8A CD4 ACE
33 tuberculoid leprosy 29.9 TNF CD8A CD4
34 anogenital venereal wart 29.8 TNF CD8A CD4
35 listeriosis 29.8 TNF CD8A CD4
36 pfeiffer syndrome 29.8 TNF CRP CD8A CD4
37 bell's palsy 29.8 TNF CRP CD8A CD4 ACE
38 viral infectious disease 29.8 TNF GPT CD4 CCR5
39 vitiligo-associated multiple autoimmune disease susceptibility 1 29.8 TNF CD8A CD4
40 allergic contact dermatitis 29.8 TNF CD8A CD4
41 human immunodeficiency virus infectious disease 29.8 TNF CD8A CD4 CCR5
42 facial paralysis 29.8 TNF CRP CD8A CD4 ACE
43 irritant dermatitis 29.7 TNF CD4
44 sarcoidosis 1 29.7 TNF CRP CD8A CD4 CCR5 ACE
45 iridocyclitis 29.7 TNF CRP CD8A CD4 ACE
46 choroiditis 29.7 TNF CRP CD4 ACE
47 retinal vasculitis 29.7 TNF CD4 ACE
48 immune deficiency disease 29.7 TNF GPT CRP CD8A CD4 CCR5
49 aphthous stomatitis 29.6 TNF CRP CD8A CD4
50 anus disease 29.6 TNF CRP CD8A CD4

Graphical network of the top 20 diseases related to Secondary Syphilis:



Diseases related to Secondary Syphilis

Symptoms & Phenotypes for Secondary Syphilis

Drugs & Therapeutics for Secondary Syphilis

Drugs for Secondary Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Linezolid Approved, Investigational Phase 3 165800-03-3 441401
2 Antibiotics, Antitubercular Phase 3
3 Anti-Bacterial Agents Phase 3
4 Anti-Infective Agents Phase 3
5
Benzylpenicillin Approved, Vet_approved 61-33-6 5904
6 Penicillins
7 Penicillin G Procaine
8 Penicillin G Benzathine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Oral and Neuro-Penetrative Alternative Antibiotics for Patients With Syphilis Recruiting NCT05069974 Phase 3 Linezolid;Benzathine Penicilllin G
2 Penicillin Therapeutic Drug Monitoring in the Treatment of Infectious Syphilis. Do Low Serum Penicillin Levels Correlate With Treatment Failure? Terminated NCT01540227 Regular Treatment for Syphilis

Search NIH Clinical Center for Secondary Syphilis

Cochrane evidence based reviews: syphilis, secondary

Genetic Tests for Secondary Syphilis

Anatomical Context for Secondary Syphilis

Organs/tissues related to Secondary Syphilis:

MalaCards : Bone, Skin, Liver, Tongue, Tonsil, Lymph Node, Whole Blood

Publications for Secondary Syphilis

Articles related to Secondary Syphilis:

(show top 50) (show all 1891)
# Title Authors PMID Year
1
Musculoskeletal manifestations of syphilis in adults: secondary syphilis presenting with ankle inflammatory arthritis and bone involvement with calvarial and sternal lesions. What the rheumatologist needs to know. 62
36454341 2022
2
Trends in the incidence of syphilis in the middle-aged and older adults in Japan: A nationwide observational study, 2009-2019. 62
36320169 2022
3
Bilateral papillitis as the initial presentation of neurosyphilis in a patient previously treated for primary and secondary syphilis. 62
36393911 2022
4
Immunization with a tri-antigen syphilis vaccine significantly attenuates chancre development, reduces bacterial load, and inhibits dissemination of Treponema pallidum. 62
36376214 2022
5
Persistently elevated risk of syphilis among HIV-positive men receiving care in a status-neutral setting: A retrospective analysis. 62
36454554 2022
6
Secondary syphilis resembling lymphoma-like nodules in a 59-year-old woman. 62
35866522 2022
7
Folliculotropic non-alopecic secondary syphilis presenting with rosary beads-like annular plaques. 62
36461772 2022
8
Anal and oral detection of Treponema pallidum in men who have sex with men with early syphilis infection. 62
35618414 2022
9
Condyloma Lata: A Useful Sign Pointing to a Diagnosis of Secondary Syphilis. 62
36462672 2022
10
Dermoscopy is a useful tool in the diagnosis of nodular secondary syphilis. 62
36368734 2022
11
Secondary syphilis of the vulva: the great imitator. 62
36336081 2022
12
Primary and Secondary Syphilis Among Men Who Have Sex With Men and Women, 2010 to 2019. 62
35312656 2022
13
Granulomatous secondary syphilis: another diagnostic pitfall for the dermatopathologist. 62
36437794 2022
14
Factors Associated With Syphilis Transmission and Acquisition Among Men Who Have Sex With Men: Protocol for a Multisite Egocentric Network Study. 62
36331528 2022
15
Syphilis With Multiple Pulmonary Nodules and Bone Lesions Detected on Computed Tomography and 18F Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography. 62
36306271 2022
16
Case of Secondary Syphilis with Mucocutaneous, Articular, and Pulmonary Involvement in a 74-Year-Old Moroccan Man. 62
36242512 2022
17
Secondary syphilis with extra-genital condyloma lata: A case report and review of the literature. 62
36113077 2022
18
Secondary Syphilis, Urticarial Eruption, and COVID-19 Vaccination. 62
35960999 2022
19
Secondary Syphilis Presentation and Urticarial Eruption After Moderna COVID-19 Vaccination Response to the Letter to the Editor. 62
35986600 2022
20
[Translated article] Granulomatous Secondary Syphilis Suggested by Histology: A Case Report. 62
36228714 2022
21
Malignant syphilis: a new and revised definition. 62
36250867 2022
22
Malignant syphilis in a young woman: A case report. 62
36217269 2022
23
Screening for Syphilis Infection in Nonpregnant Adolescents and Adults: US Preventive Services Task Force Reaffirmation Recommendation Statement. 62
36166020 2022
24
A single dose of benzathine penicillin G as an effective treatment for malignant syphilis in an HIV-positive patient: a case report. 62
36149278 2022
25
Acquired oral syphilis: A multicenter study of 339 patients from South America. 62
34263964 2022
26
Granulomatous Secondary Syphilis: An Uncommon Presentation of the Great Imitator. 62
36181788 2022
27
Gaps in HIV Preexposure Prophylaxis Continuum of Care Following State Partner Services for Massachusetts Primary and Secondary Syphilis Cases, 2017 to 2018. 62
35797587 2022
28
Diffused nodular secondary syphilis. 62
36047832 2022
29
Exposing the Great Imitator: Proposal for a Holistic Diagnosis of Oral Secondary Syphilis in People Living with HIV. 62
35334094 2022
30
Pathogenesis, Diagnosis, Antimicrobial Therapy, and Management of Infective Endocarditis, and Its Complications. 62
36258995 2022
31
Detection of Treponema pallidum DNA During Early Syphilis Stages in Peripheral Blood, Oropharynx, Ano-Rectum and Urine as a Proxy for Transmissibility. 62
35079776 2022
32
Secondary syphilis: An ecthyma-like syphilis case report. 62
35710538 2022
33
Secondary Syphilis Presenting as Erythema Multiforme in the Setting of AIDS and Psoriasis. 62
36259021 2022
34
Annular rupioid secondary syphilis confined to the face. 62
35842215 2022
35
A Rare Presentation of Undiagnosed Systemic Syphilis: A Case Report and Review of Literature. 62
36110468 2022
36
Secondary Syphilis Presenting as Bilateral Simultaneous Papillitis in an Immunocompetent Individual. 62
36176871 2022
37
Condyloma Lata: A Useful Sign Pointing to a Diagnosis of Secondary Syphilis. 62
35963329 2022
38
False negative RPR test with prozone phenomenon in an HIV-negative man with secondary syphilis. 62
35305047 2022
39
Annular and Psoriasiform Secondary Syphilis in a Nine-Year-Old Girl Child: A Case Report. 62
36158402 2022
40
A suite of PCR-LwCas13a assays for detection and genotyping of Treponema pallidum in clinical samples. 62
35945210 2022
41
Associations of toluidine red unheated serum test response to the treatment of syphilis in pregnancy and congenital syphilis: a 10-year real-world study. 62
35830212 2022
42
Detection of A2058G and A2059G on the 23S rRNA Gene by Multiplex Nested PCR to Identify Treponema pallidum Resistance to Azithromycin in Indonesia. 62
34980709 2022
43
Exploring the Ways of "The Great Imitator": A Case Report of Syphilitic Hepatitis. 62
35979246 2022
44
Secondary Syphilis Presentation and Urticarial Eruption After Moderna COVID-19 Vaccination. 62
35778833 2022
45
Condylomata Lata and Papular Rash of Secondary Syphilis. 62
35850231 2022
46
Looks Like Neurosyphilis, Feels Like Guillain-Barre: At the Confluence of Infection and Immunology. 62
35911366 2022
47
Mucocutaneous manifestations and their relationship with CD4 T-lymphocyte count in hospitalized patients infected with the human immunodeficiency virus (HIV) in MedellĂ­n, Colombia 62
35867921 2022
48
Secondary syphilis of the oropharynx and cervical lymph nodes: a case report. 62
35710349 2022
49
Follmann balanitis and anetoderma in secondary syphilis. 62
35795840 2022
50
Clinical and laboratory aspects of condylomata lata lesions of syphilis. 62
35732476 2022

Variations for Secondary Syphilis

Expression for Secondary Syphilis

Search GEO for disease gene expression data for Secondary Syphilis.

Pathways for Secondary Syphilis

Pathways related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 TNF CD8A CD4
2
Show member pathways
11.48 CD8A CD4 CCR5
3 11.23 TNF CD8A CD4
4
Show member pathways
11.02 CRP CD8A CD4
5 10.68 TNF CRP
6 10.67 TNF CD8A CD4
7 10.54 CD4 CCR5

GO Terms for Secondary Syphilis

Cellular components related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.32 TNF CD8A CD4 CCR5 ACE

Biological processes related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of lipid storage GO:0010888 8.92 TNF CRP

Molecular functions related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 9.1 CD8A CD4 CCR5

Sources for Secondary Syphilis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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