MCID: SCN006
MIFTS: 39

Secondary Syphilis

Categories: Bone diseases, Fetal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Secondary Syphilis

MalaCards integrated aliases for Secondary Syphilis:

Name: Secondary Syphilis 12 15
Syphilis, Secondary 45 74
Secondary Syphilis of Viscera or Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4157
ICD9CM 36 091.9
MeSH 45 C536773
NCIt 51 C128413
UMLS 74 C0149985

Summaries for Secondary Syphilis

Disease Ontology : 12 A syphilis that is characterized as the second stage of syphilis which appears from 2 to 6 months after primary infection, and is marked by lesions especially in the skin but also in organs and tissues, and that lasts from 3 to 12 weeks.

MalaCards based summary : Secondary Syphilis, also known as syphilis, secondary, is related to asymptomatic neurosyphilis and syphilis. An important gene associated with Secondary Syphilis is FN1 (Fibronectin 1), and among its related pathways/superpathways are Primary immunodeficiency and Inflammatory Response Pathway. The drugs Procaine and Penicillin G have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and tonsil.

Related Diseases for Secondary Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Secondary Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 asymptomatic neurosyphilis 32.0 DDX41 EXTL3
2 syphilis 30.8 CD209 CD40LG CD79A DDX41 EXTL3 POLA1
3 congenital syphilis 30.3 CD40LG CD79A DDX41 EXTL3 POLA1
4 sporotrichosis 30.0 CD40LG CD79A
5 tertiary syphilis 29.6 DDX41 EXTL3
6 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 29.4 CD209 CD40LG
7 hepatitis 10.4
8 nephrotic syndrome 10.2
9 c1q nephropathy 10.2 CD40LG CD79A
10 immunoglobulin g deficiency 10.2 CD40LG CD79A
11 heparin-induced thrombocytopenia 10.2 CD40LG CD79A
12 immunoglobulin a deficiency 1 10.2 CD40LG CD79A
13 immunodeficiency-centromeric instability-facial anomalies syndrome 1 10.2 CD40LG CD79A
14 ocular toxoplasmosis 10.2 CD40LG CD79A
15 alopecia 10.2
16 toxoplasmosis 10.2 CD40LG CD79A
17 persistent generalized lymphadenopathy 10.2 CD40LG CD79A
18 immunodeficiency with hyper-igm, type 1 10.1 CD40LG CD79A
19 congenital toxoplasmosis 10.1 CD40LG CD79A
20 lymphoma 10.1
21 human immunodeficiency virus infectious disease 10.1
22 immunoglobulin alpha deficiency 10.1 CD40LG CD79A
23 cryptosporidiosis 10.1 CD40LG CD79A
24 pustulosis palmaris et plantaris 10.1 CD40LG CD79A
25 dysgerminoma of ovary 10.1 CD40LG CD79A
26 dengue disease 10.1 CD209 CD40LG
27 marginal zone b-cell lymphoma 10.1 CD40LG CD79A
28 agammaglobulinemia, x-linked 10.1 CD40LG CD79A
29 meningoencephalitis 10.1 CD40LG CD79A
30 erythema multiforme 10.1
31 bone inflammation disease 10.1
32 gastritis 10.1
33 psoriasis 10.1
34 cryoglobulinemia 10.1 CD40LG CD79A
35 arthritis 10.0
36 lichen planus 10.0
37 cryofibrinogenemia 10.0 CD40LG CD79A FN1
38 immune deficiency disease 10.0 CD40LG CD79A
39 iga glomerulonephritis 10.0 CD40LG CD79A
40 kaposi sarcoma 9.9
41 glomerulonephritis 9.9
42 sarcoma 9.9
43 uveitis 9.9
44 lupus erythematosus 9.9
45 chorioretinitis 9.9
46 meningitis 9.9
47 periostitis 9.9
48 anterior uveitis 9.9
49 pityriasis lichenoides 9.9
50 late congenital syphilis 9.9 DDX41 EXTL3

Graphical network of the top 20 diseases related to Secondary Syphilis:



Diseases related to Secondary Syphilis

Symptoms & Phenotypes for Secondary Syphilis

Drugs & Therapeutics for Secondary Syphilis

Drugs for Secondary Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
2
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
3 Anti-Infective Agents Phase 4
4 Penicillin G Benzathine Phase 4
5 penicillins Phase 4
6 Anti-Bacterial Agents Phase 4
7 Penicillin G Procaine Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
2 Comparisons of Serologic Response of Early Syphilis Completed NCT01944358
3 Penicillin Therapeutic Drug Monitoring in the Treatment of Infectious Syphilis. Terminated NCT01540227 Regular Treatment for Syphilis

Search NIH Clinical Center for Secondary Syphilis

Cochrane evidence based reviews: syphilis, secondary

Genetic Tests for Secondary Syphilis

Anatomical Context for Secondary Syphilis

MalaCards organs/tissues related to Secondary Syphilis:

42
Skin, Bone, Tonsil, T Cells, Testes, Tongue, Lymph Node

Publications for Secondary Syphilis

Articles related to Secondary Syphilis:

(show top 50) (show all 671)
# Title Authors Year
1
Moth-eaten alopecia in secondary syphilis. ( 30807867 )
2019
2
Secondary syphilis presenting as erythema multiforme in a HIV-positive homosexual man: a case report and literature review. ( 30482099 )
2019
3
Cervical syphilitic lymphadenitis causing fever of unknown origin followed by rash of secondary syphilis. ( 30971574 )
2019
4
Altered Appearance of Secondary Syphilis Rash Within a Preexisting Tattoo. ( 30363028 )
2019
5
Annular secondary syphilis. ( 30616335 )
2019
6
Rounded atrophic areas on the dorsum of the tongue: plaques en prairie fauchée of secondary syphilis. ( 30622897 )
2019
7
Nodulo-ulcerative and erythrodermic secondary syphilis in human immunodeficiency virus-infected individuals. ( 30630397 )
2019
8
Vegetating lesions in secondary syphilis. ( 30748034 )
2019
9
Increased Methamphetamine, Injection Drug, and Heroin Use Among Women and Heterosexual Men with Primary and Secondary Syphilis - United States, 2013-2017. ( 30763294 )
2019
10
Lichenoid skin lesions: A rare manifestation in secondary syphilis. ( 30785122 )
2019
11
Geographic correlates of primary and secondary syphilis among men who have sex with men in the United States. ( 30799206 )
2019
12
Dermoscopic clues in the skin lesions of secondary syphilis. ( 30899465 )
2019
13
Vegetating lesions in secondary syphilis. Reply from authors. ( 30941790 )
2019
14
Biett's sign: a hallmark sign of secondary syphilis. ( 30994813 )
2019
15
Immune reconstitution inflammatory syndrome associated with secondary syphilis: dermatologic, neurologic and ophthalmologic compromise in an HIV patient. ( 30999832 )
2019
16
Beyond appearance: An unusual manifestation of isolated oral secondary syphilis. ( 31020874 )
2019
17
Syphilitic gastritis: a rare presentation of secondary syphilis. ( 29523617 )
2018
18
Unusual presentation of secondary syphilis: membranoproliferative glomerulonephritis andmuco-cutaneous lesions. ( 28950764 )
2018
19
Secondary syphilis presented with impetigo-like lesions: a rare case report. ( 30094832 )
2018
20
Secondary Syphilis Associated with Membranous Nephropathy and Acute Hepatitis in a Patient with HIV: A Case Report. ( 29236656 )
2018
21
Secondary Syphilis Mimicking Giant Cell Arteritis. ( 29561471 )
2018
22
A case of secondary syphilis with pulmonary involvement and review of the literature. ( 29621949 )
2018
23
Rare Case of Four Osseous Lesions of the Skull in a Patient with Secondary Syphilis. ( 29854502 )
2018
24
Secondary syphilis: an atypical presentation complicated by a false negative rapid plasma reagin test. ( 29894545 )
2018
25
Annular and arcuate syphilis: an uncommon presentation of disseminated secondary syphilis. ( 29906011 )
2018
26
Fulminant hepatitis in a patient with secondary syphilis. ( 29979145 )
2018
27
Unusual Manifestations of Secondary Syphilis: Case Presentations. ( 29989879 )
2018
28
Oral ulcers as a presentation of secondary syphilis. ( 30039628 )
2018
29
The disappearance of femoral head and neck resulting from extensive bone defect caused by secondary syphilis: a case report and literature review. ( 30045704 )
2018
30
An unusual giant serpiginous lesion of secondary syphilis. ( 30066774 )
2018
31
Secondary syphilis presenting as a corymbiform syphilide: case report and review. ( 30133600 )
2018
32
Secondary syphilis masquerading as lupus vulgaris in an HIV-infected patient: A diagnosis suggested by histology. ( 30170530 )
2018
33
Treponema Pallidum Epidermotropism in Nodular Secondary Syphilis. ( 30504982 )
2018
34
Fetal response to intramuscular epinephrine for anaphylaxis during maternal penicillin desensitization for secondary syphilis. ( 28562129 )
2018
35
Pulmonary involvement of secondary syphilis. ( 28661232 )
2018
36
Secondary Syphilis with Pulmonary Involvement. ( 29021433 )
2018
37
Primary and Secondary Syphilis as Chancre of the Mouth with Rash. ( 29033418 )
2018
38
Acute hepatitis as a manifestation of secondary syphilis. ( 29054317 )
2018
39
Mucocutaneous Secondary Syphilis: 'The Great Imitator'. ( 29079400 )
2018
40
Cross-sectional study of Treponema pallidum PCR in diagnosis of primary and secondary syphilis. ( 29090453 )
2018
41
Secondary Syphilis Without Any History of Primary Infection. ( 29366456 )
2018
42
A secondary syphilis rash with scaly target lesions. ( 29410787 )
2018
43
Differences in Partner Services Outcomes for Men Who Have Sex With Men Diagnosed With Primary and Secondary Syphilis by HIV Serostatus. ( 29420442 )
2018
44
Reported Primary and Secondary Syphilis Cases in the United States: Implications for HIV Infection. ( 29465633 )
2018
45
Oral findings in secondary syphilis. ( 29476680 )
2018
46
A Young Boy with Persistent Nodules and Hoarseness: A Rare Presentation of Nodular Secondary Syphilis. ( 29482701 )
2018
47
Secondary Syphilis with Tonsillar and Cervical Lymphadenopathy and a Pulmonary Lesion Mimicking Malignant Lymphoma. ( 29502129 )
2018
48
Secondary syphilis: lest we forget it. ( 29545459 )
2018
49
An Emergency Department Presentation of Secondary Syphilis. ( 29547908 )
2018
50
Image Gallery: Moth-eaten alopecia as the only cutaneous symptom of acquired secondary syphilis in a 2-year-old boy. ( 29192994 )
2017

Variations for Secondary Syphilis

Expression for Secondary Syphilis

Search GEO for disease gene expression data for Secondary Syphilis.

Pathways for Secondary Syphilis

Pathways related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 CD40LG CD79A
2 10.14 CD40LG FN1

GO Terms for Secondary Syphilis

Cellular components related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD209 CD40LG CD79A

Biological processes related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 9.26 CD40LG CD79A
2 positive regulation of T cell proliferation GO:0042102 9.16 CD209 CD40LG
3 B cell proliferation GO:0042100 8.96 CD40LG CD79A
4 leukocyte cell-cell adhesion GO:0007159 8.62 CD209 CD40LG

Sources for Secondary Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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