MCID: SCN006
MIFTS: 40

Secondary Syphilis

Categories: Infectious diseases, Bone diseases, Neuronal diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Secondary Syphilis

MalaCards integrated aliases for Secondary Syphilis:

Name: Secondary Syphilis 12 15
Syphilis, Secondary 44 73
Secondary Syphilis of Viscera or Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4157
ICD9CM 35 091.9
MeSH 44 C536773
UMLS 73 C0149985

Summaries for Secondary Syphilis

Disease Ontology : 12 A syphilis that is characterized as the second stage of syphilis which appears from 2 to 6 months after primary infection, and is marked by lesions especially in the skin but also in organs and tissues, and that lasts from 3 to 12 weeks.

MalaCards based summary : Secondary Syphilis, also known as syphilis, secondary, is related to asymptomatic neurosyphilis and sporotrichosis. An important gene associated with Secondary Syphilis is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Primary immunodeficiency and Inflammatory Response Pathway. The drugs Penicillin G and Procaine have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and liver.

Related Diseases for Secondary Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Secondary Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 246)
# Related Disease Score Top Affiliating Genes
1 asymptomatic neurosyphilis 30.7 CD40LG CD79A DDX41 EXTL3
2 sporotrichosis 30.7 CD40LG CD79A
3 granulomatous hepatitis 30.4 CD40LG CD79A
4 chickenpox 30.3 CD40LG CD79A
5 indeterminate leprosy 30.2 CD40LG CD79A
6 syphilitic meningitis 30.2 CD40LG EXTL3
7 neuroretinitis 30.0 CD40LG EXTL3
8 chorioretinitis 29.9 CD40LG CD79A EXTL3
9 yaws 29.7 EXTL3 TPR
10 congenital syphilis 29.2 CD40LG CD79A DDX41 EXTL3 POLA1
11 syphilis 29.0 CD40LG CD79A DDX41 EXTL3 POLA1 TPR
12 selective igg deficiency disease 10.7 CD40LG CD79A
13 c1q nephropathy 10.7 CD40LG CD79A
14 meningovascular neurosyphilis 10.7 CD40LG CD79A
15 alpha chain disease 10.7 CD40LG CD79A
16 brill-zinsser disease 10.7 CD40LG CD79A
17 exudative glomerulonephritis 10.7 CD40LG CD79A
18 cork-handlers' disease 10.7 CD40LG CD79A
19 salpingo-oophoritis 10.7 CD40LG CD79A
20 ventilation pneumonitis 10.7 CD40LG CD79A
21 chronic interstitial cystitis 10.7 CD40LG CD79A
22 axillary adenitis 10.7 CD40LG CD79A
23 trichostrongyloidiasis 10.7 CD40LG CD79A
24 subacute bacterial endocarditis 10.7 CD40LG CD79A
25 heterophyiasis 10.7 CD40LG CD79A
26 immunoglobulin g deficiency 10.7 CD40LG CD79A
27 orbital granuloma 10.7 CD40LG CD79A
28 transient hypogammaglobulinemia of infancy 10.7 CD40LG CD79A
29 hyperglobulinemic purpura 10.7 CD40LG CD79A
30 gastroduodenitis 10.7 CD40LG CD79A
31 bacterial conjunctivitis 10.7 CD40LG CD79A
32 heavy chain disease 10.7 CD40LG CD79A
33 ophthalmia neonatorum 10.7 CD40LG CD79A
34 immunoglobulin a deficiency 1 10.7 CD40LG CD79A
35 parotid disease 10.7 CD40LG CD79A
36 cerebral arteritis 10.7 CD40LG CD79A
37 selective immunoglobulin deficiency disease 10.7 CD40LG CD79A
38 geniculate herpes zoster 10.7 CD40LG CD79A
39 erythema elevatum diutinum 10.7 CD40LG CD79A
40 fallopian tube disease 10.7 CD40LG CD79A
41 hyperimmunoglobulin syndrome 10.7 CD40LG CD79A
42 polyclonal hypergammaglobulinemia 10.7 CD40LG CD79A
43 monoclonal paraproteinemia 10.7 CD40LG CD79A
44 salpingitis 10.7 CD40LG CD79A
45 ocular toxoplasmosis 10.7 CD40LG CD79A
46 dysgammaglobulinemia 10.7 CD40LG CD79A
47 congenital hypogammaglobulinemia 10.7 CD40LG CD79A
48 acute maxillary sinusitis 10.7 CD40LG CD79A
49 chronic polyneuropathy 10.7 CD40LG CD79A
50 spinocerebellar ataxia, autosomal recessive 10 10.7 CD40LG CD79A

Graphical network of the top 20 diseases related to Secondary Syphilis:



Diseases related to Secondary Syphilis

Symptoms & Phenotypes for Secondary Syphilis

Drugs & Therapeutics for Secondary Syphilis

Drugs for Secondary Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
2
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
3 Anti-Bacterial Agents Phase 4
4 Anti-Infective Agents Phase 4
5 Penicillin G Benzathine Phase 4
6 Penicillin G Procaine Phase 4
7 penicillins Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
2 Comparisons of Serologic Response of Early Syphilis Completed NCT01944358
3 Penicillin Therapeutic Drug Monitoring in the Treatment of Infectious Syphilis. Terminated NCT01540227 Regular Treatment for Syphilis

Search NIH Clinical Center for Secondary Syphilis

Cochrane evidence based reviews: syphilis, secondary

Genetic Tests for Secondary Syphilis

Anatomical Context for Secondary Syphilis

MalaCards organs/tissues related to Secondary Syphilis:

41
Skin, Bone, Liver, Tonsil, Testes, Tongue, T Cells

Publications for Secondary Syphilis

Articles related to Secondary Syphilis:

(show top 50) (show all 596)
# Title Authors Year
1
A case of secondary syphilis with pulmonary involvement and review of the literature. ( 29621949 )
2018
2
Oral findings in secondary syphilis. ( 29476680 )
2018
3
Secondary syphilis: an atypical presentation complicated by a false negative rapid plasma reagin test. ( 29894545 )
2018
4
Secondary syphilis: lest we forget it. ( 29545459 )
2018
5
Cross-sectional study of Treponema pallidum PCR in diagnosis of primary and secondary syphilis. ( 29090453 )
2018
6
Rare Case of Four Osseous Lesions of the Skull in a Patient with Secondary Syphilis. ( 29854502 )
2018
7
Secondary Syphilis with Tonsillar and Cervical Lymphadenopathy and a Pulmonary Lesion Mimicking Malignant Lymphoma. ( 29502129 )
2018
8
Annular and arcuate syphilis: an uncommon presentation of disseminated secondary syphilis. ( 29906011 )
2018
9
An Emergency Department Presentation of Secondary Syphilis. ( 29547908 )
2018
10
Primary and Secondary Syphilis as Chancre of the Mouth with Rash. ( 29033418 )
2018
11
Secondary Syphilis Mimicking Giant Cell Arteritis. ( 29561471 )
2018
12
Secondary Syphilis Without Any History of Primary Infection. ( 29366456 )
2018
13
Fulminant hepatitis in a patient with secondary syphilis. ( 29979145 )
2018
14
Secondary Syphilis with Pulmonary Involvement. ( 29021433 )
2018
15
Syphilitic gastritis: a rare presentation of secondary syphilis. ( 29523617 )
2018
16
A secondary syphilis rash with scaly target lesions. ( 29410787 )
2018
17
Mucocutaneous Secondary Syphilis: 'The Great Imitator'. ( 29079400 )
2018
18
Reported Primary and Secondary Syphilis Cases in the United States: Implications for HIV Infection. ( 29465633 )
2018
19
Differences in Partner Services Outcomes for Men Who Have Sex With Men Diagnosed With Primary and Secondary Syphilis by HIV Serostatus. ( 29420442 )
2018
20
A Young Boy with Persistent Nodules and Hoarseness: A Rare Presentation of Nodular Secondary Syphilis. ( 29482701 )
2018
21
Image Gallery: Moth-eaten alopecia as the only cutaneous symptom of acquired secondary syphilis in a 2-year-old boy. ( 29192994 )
2017
22
Fetal response to intramuscular epinephrine for anaphylaxis during maternal penicillin desensitization for secondary syphilis. ( 28562129 )
2017
23
Papulonodular Secondary Syphilis Presenting as Multiple Distinct Cutaneous Lesions in an HIV-Positive Transgender Woman. ( 28512403 )
2017
24
Anetoderma due to secondary syphilis: Report of two cases and discussion of the histopathological findings. ( 28571518 )
2017
25
Secondary syphilis presenting as leucoderma syphiliticum: case report and review. ( 29116294 )
2017
26
Secondary syphilis-related oral mucous patches. ( 28593145 )
2017
27
Stevens Johnson Syndrome versus Jarisch Herxheimer Reaction in an HIV Positive Patient with Secondary Syphilis. ( 29076438 )
2017
28
Development and Evaluation of a Loop-Mediated Isothermal Amplification Assay for the Detection of<i>Treponema pallidum</i>DNA in the Peripheral Blood of Secondary Syphilis Patients. ( 29016285 )
2017
29
Brief report: Use of ICD-10 code A51.31 (condyloma latum) for identifying cases of secondary syphilis. ( 28953413 )
2017
30
Rates of Primary and Secondary Syphilis Among White and Black non-Hispanic Men Who Have Sex with Men, US States, 2014. ( 28749823 )
2017
31
Ocular involvement with secondary syphilis in a non-HIV infected man. ( 28840111 )
2017
32
New imaging tools for an old disease: Secondary syphilis. ( 28718501 )
2017
33
Secondary Syphilis Presenting As Palmoplantar Psoriasis. ( 28785328 )
2017
34
Pulmonary involvement of secondary syphilis. ( 28661232 )
2017
35
Secondary Syphilis Presenting as Glossodynia, Plaques en Prairie FauchAce, and a Split Papule at the Oral Commissure: Case Report and Review. ( 28785283 )
2017
36
Unusual presentation of secondary syphilis: membranoproliferative glomerulonephritis andmuco-cutaneous lesions. ( 28950764 )
2017
37
Secondary syphilis primarily presenting with multiple nodules on the scalp: Case report and published work review. ( 28714113 )
2017
38
Secondary Syphilis Associated with Membranous Nephropathy and Acute Hepatitis in a Patient with HIV: A Case Report. ( 29236656 )
2017
39
Secondary syphilis: The great imitator can't be forgotten. ( 28876421 )
2017
40
Secondary syphilis: An unusual presentation. ( 28442816 )
2017
41
Acute hepatitis as a manifestation of secondary syphilis. ( 29054317 )
2017
42
The Diagnosis of Secondary Syphilis by Gram and Giemsa Staining. ( 28768989 )
2017
43
Psoriasiform papules, condyloma lata, lung nodules and hepatitis: the enormous variability of secondary syphilis manifestations. ( 28476906 )
2017
44
Rare isolated oral manifestations of secondary syphilis in an adolescent. ( 29099372 )
2017
45
Secondary syphilis. ( 28696198 )
2017
46
Secondary syphilis mimicking malignancy: A case report and review of literature. ( 28456488 )
2017
47
Secondary syphilis infection under treatment with ustekinumab. ( 28866870 )
2017
48
Clinicopathologic features, microvessel density, and immunohistochemical expression of ICAM-1 and VEGF in 15 cases of secondary syphilis with oral manifestations. ( 26682516 )
2016
49
Secondary Syphilis With Hepatitis and Nephrotic Syndrome: A Rare Concurrence. ( 27298666 )
2016
50
Syphilis: an atypical case of sepsis and multiple anogenital lesions in secondary syphilis. ( 27802854 )
2016

Variations for Secondary Syphilis

Expression for Secondary Syphilis

Search GEO for disease gene expression data for Secondary Syphilis.

Pathways for Secondary Syphilis

Pathways related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 CD40LG CD79A
2 10.14 CD40LG FN1

GO Terms for Secondary Syphilis

Cellular components related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 host cell GO:0043657 8.96 CD209 TPR
2 external side of plasma membrane GO:0009897 8.8 CD209 CD40LG CD79A

Biological processes related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell proliferation GO:0042102 9.26 CD209 CD40LG
2 intracellular transport of virus GO:0075733 9.16 CD209 TPR
3 B cell proliferation GO:0042100 8.96 CD40LG CD79A
4 leukocyte cell-cell adhesion GO:0007159 8.62 CD209 CD40LG

Sources for Secondary Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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