Secondary Syphilis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SCN006 MIFTS: 36	Secondary Syphilis Categories: Bone diseases, Fetal diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Secondary Syphilis

MalaCards integrated aliases for Secondary Syphilis:

Name: Secondary Syphilis ¹² ¹⁵

Syphilis, Secondary ⁴⁴ ⁷⁰

Secondary Syphilis of Viscera or Bone ¹²

Classifications:

MalaCards categories:
Global: Infectious diseases Fetal diseases Rare diseases
Anatomical: Bone diseases Neuronal diseases Skin diseases Immune diseases Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4157

ICD9CM ³⁴ 091.9

MeSH ⁴⁴ C536773

NCIt ⁵⁰ C128413

SNOMED-CT ⁶⁷ 154382002

UMLS ⁷⁰ C0149985

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Summaries for Secondary Syphilis

Disease Ontology : ¹² A syphilis that is characterized as the second stage of syphilis which appears from 2 to 6 months after primary infection, and is marked by lesions especially in the skin but also in organs and tissues, and that lasts from 3 to 12 weeks.

MalaCards based summary : Secondary Syphilis, also known as syphilis, secondary, is related to asymptomatic neurosyphilis and exanthem. An important gene associated with Secondary Syphilis is CD209 (CD209 Molecule), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. Affiliated tissues include skin, bone and lung.

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Related Diseases for Secondary Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis	Late Congenital Syphilis
Primary Syphilis	Secondary Syphilis
Congenital Syphilis

Diseases related to Secondary Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 510)

#	Related Disease	Score	Top Affiliating Genes
1	asymptomatic neurosyphilis	31.9	CXCL13 CD4
2	exanthem	30.9	CRP CD8A CD4
3	congenital syphilis	30.8	TPR POLA1 EPB41L3 CD79A CD40LG CD4
4	glomerulonephritis	30.6	FN1 CD79A CD40LG
5	leprosy 3	30.5	CD8A CD4 CD209
6	iridocyclitis	30.4	CRP CD4
7	neuroretinitis	30.3	CRP CD4
8	bell's palsy	30.3	CD8A CD4
9	optic papillitis	30.3	CRP CD4
10	tenosynovitis	30.3	CRP CD4
11	bone inflammation disease	30.2	CRP CD8A CD4
12	aortitis	30.2	CRP CD4
13	sporotrichosis	30.1	CD79A CD40LG CD4
14	chorioretinitis	30.1	CRP CD8A CD4
15	lung abscess	30.1	CRP CD4
16	yaws	30.0	TPR POLA1 EPB41L3
17	facial paralysis	30.0	CRP CD8A CD4
18	oral hairy leukoplakia	30.0	CD8A CD4
19	granulomatous dermatitis	30.0	CD8A CD4
20	vasculitis	29.9	CRP CD79A CD40LG
21	granulomatous hepatitis	29.9	CRP CD8A CD4
22	lymphadenitis	29.9	CRP CD4 CD209
23	alopecia universalis congenita	29.9	CD8A CD4
24	primary syphilis	29.9	TPR POLA1 CRP CD8A CD4
25	syphilis	29.8	TPR POLA1 FN1 CRP CD8A CD79A
26	early yaws	29.8	TPR CD8A CD4
27	iritis	29.8	CRP CD8A CD4
28	chickenpox	29.7	CRP CD8A CD4
29	pharyngitis	29.7	CRP CD8A CD4
30	panuveitis	29.7	CRP CD8A CD4
31	pfeiffer syndrome	29.7	CD8A CD40LG CD4
32	sarcoidosis 1	29.6	CRP CD8A CD4 CCR5
33	skin disease	29.6	CRP CD8A CD79A CD4
34	tertiary syphilis	29.6	TPR CXCL13 CRP CD8A CD4
35	fungal infectious disease	29.5	CRP CD8A CD4 CD209
36	severe cutaneous adverse reaction	29.5	CRP CD8A CD4
37	syphilitic meningitis	29.5	CXCL13 CRP CD8A CD4
38	latent syphilis	29.4	TPR POLA1 CXCL13 CD8A CD4
39	parotitis	29.3	CRP CD8A CD79A CD4
40	autoimmune disease	29.3	CRP CD79A CD40LG CCR5
41	disease by infectious agent	29.2	CRP CD8A CD4 CD209 CCR5
42	acquired immunodeficiency syndrome	29.2	CRP CD79A CD40LG CD4 CCR5
43	human immunodeficiency virus infectious disease	29.1	CD8A CD79A CD4 CD209 CCR5
44	immune deficiency disease	28.7	FN1 CRP CD8A CD79A CD40LG CD4
45	inflammatory bowel disease	28.6	CRP CD8A CD40LG CD209 CCR5
46	systemic lupus erythematosus	28.2	CXCL13 CRP CD79A CD40LG CD4 CCR5
47	nephrotic syndrome	10.5
48	alopecia	10.5
49	neurosyphilis	10.4
50	hemorrhagic fever-renal syndrome	10.4	CD79A CD40LG

Graphical network of the top 20 diseases related to Secondary Syphilis:

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Symptoms & Phenotypes for Secondary Syphilis

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Drugs & Therapeutics for Secondary Syphilis

Search Clinical Trials , NIH Clinical Center for Secondary Syphilis

Cochrane evidence based reviews: syphilis, secondary

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Genetic Tests for Secondary Syphilis

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Anatomical Context for Secondary Syphilis

MalaCards organs/tissues related to Secondary Syphilis:

⁴⁰

Skin, Bone, Lung, Tongue, Eye, Lymph Node, Myeloid

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Publications for Secondary Syphilis

Articles related to Secondary Syphilis:

(show top 50) (show all 1729)

#	Title	Authors	PMID	Year
1	Condyloma lata in secondary syphilis. ⁶¹	Pourang A...Brassard A	33732839	2021
2	Cerebral syphilitic gumma presenting with intracranial gumma and pathologic vertebrae fractures. ⁶¹	Thibodeau R...Swarnkar A	33613804	2021
3	A unique presentation of papulonodular secondary syphilis in an elderly patient. ⁶¹	Correia C...Filipe P	33763862	2021
4	Scrotal plaques as a predominant presentation in a case of secondary syphilis. ⁶¹	Bains A...Tyagi N	33769741	2021
5	When hair loss is not just a cosmetic problem: Moth-eaten alopecia in secondary syphilis. ⁶¹	Vaccaro M...Guarneri F	33768667	2021
6	Oral manifestations of syphilis: an epidemiological study in southern Brazil. ⁶¹	Thums MA...Salum FG	33656756	2021
7	Secondary syphilis presenting as oral ulcers. ⁶¹	Sil A...Chakraborty S	31900252	2021
8	Secondary Syphilis With Elastophagocytosis: An Unusual Histologic Finding. ⁶¹	Henebeng E...DiMarco C	33298710	2021
9	Malignant Syphilis: A Systematic Review of the Case Reports Published in 2014-2018. ⁶¹	Wibisono O...Djawad K	33811833	2021
10	Pigtail hairs in syphilitic alopecia. ⁶¹	Gomes TF...Guiote V	33783889	2021
11	Cauliflower-shaped lesions on a young woman's vulva. ⁶¹	Yuan T...Li H	33533298	2021
12	Clinical presentation of incident syphilis among men who have sex with men taking HIV Pre-Exposure Prophylaxis in Melbourne, Australia. ⁶¹	Peel J...Chen MY	33522575	2021
13	A Case of Rapidly Proliferative Glomerulonephritis Secondary to Syphilis That Responded to Treatment With Penicillin. ⁶¹	Siddiqui RS...Abrudescu A	33777557	2021
14	A case of macular rash misleading to drug eruption in secondary syphilis. ⁶¹	Nagaoka S...Igawa K	33219710	2021
15	Secondary syphilis with liver involvement in a liver transplant recipient. ⁶¹	Ferrandiz-Pulido C...Castells L	32738832	2021
16	The impact of the SARS-CoV-2 pandemic on HIV and bacterial sexually transmitted infection testing and diagnosis in Oregon. ⁶¹	Menza TW...Ferrer J	33534405	2021
17	Syphilitic Pulmonary Inflammatory Pseudotumor: A Diagnostic Challenge. ⁶¹	Govender D...Chetty D	32486870	2021
18	Clinical outcomes of syphilis in HIV-negative and HIV-positive MSM: occurrence of repeat syphilis episodes and non-treponemal serology responses. ⁶¹	Nieuwenburg SA...de Vries HJC	33608479	2021
19	Oral forms of secondary syphilis: An illustration of the pitfalls set by the great imitator. ⁶¹	Lampros A...Dupin N	32339705	2021
20	An Investigation of Early Syphilis Among Men Who have Sex with Men: Alaska, 2018: Findings from a 2018 Rapid Ethnographic Assessment. ⁶¹	Loosier PS...McLaughlin J	32410089	2021
21	An unusual case of oral condyloma lata. ⁶¹	Dai T...Song NJ	33607303	2021
22	Azithromycin resistance in Treponema pallidum in Reunion Island: A cross-sectional study. ⁶¹	Bourgeois G...Bertolotti A	33608114	2021
23	Secondary syphilis with alopecia and ocular manifestation. ⁶¹	Chang KM...Wallach F	33423955	2021
24	Serological diagnosis of secondary syphilis in a Rituximab-treated patient: an emerging diagnostic challenge? ⁶¹	Lefeuvre C...Le Clec'h C	33462864	2021
25	Oral Manifestations of Syphilis: a Review of the Clinical and Histopathologic Characteristics of a Reemerging Entity with Report of 19 New Cases. ⁶¹	Smith MH...Rawal YB	33459991	2021
26	Jarisch-Herxheimer Reaction After Cephalosporin Administration in Syphilis. ⁶¹	McKenzie C...Olges J	33643725	2021
27	Rectal cancer mimic: a rare case of syphilitic proctitis. ⁶¹	Patil RV...Griffin Y	33370929	2020
28	An unusual case of secondary syphilis misdiagnosed as allergic dermatitis for 2 years. ⁶¹	Wang HW...Zhang RZ	33363789	2020
29	Sporotrichoid secondary syphilis. ⁶¹	Mazori DR...Heilman ER	33314047	2020
30	Oral Lesions as the Only Manifestation of Secondary Syphilis. ⁶¹	Gonzalez-Ruiz L...Ramos-Rodriguez C	32679120	2020
31	Do not miss secondary syphilis: examine the palms and soles. ⁶¹	Hughes Y	33234557	2020
32	Annular and arciform lesions of the palms as unique manifestations of secondary syphilis. ⁶¹	Parodi M...Parodi A	32981425	2020
33	Visual Dermatology: Overlapping Primary and Secondary Syphilis Mimicking Penile Carcinoma. ⁶¹	Pisano L...Tiradritti L	32716635	2020
34	The challenging diagnosis of overlapping oral primary/secondary syphilis with nonreactive serology. ⁶¹	Ramirez-Amador V...Calva-Mercado JJ	32666536	2020
35	Kidney disease in secondary syphilis: a case report. ⁶¹	Erlij D...Sepulveda P	33168357	2020
36	Management of syphilitic hepatitis. ⁶¹	Kaya A...Kaya SY	33183229	2020
37	Nowcasting Sexually Transmitted Infections in Chicago: Predictive Modeling and Evaluation Study Using Google Trends. ⁶¹	Johnson AK...Mehta SD	33151162	2020
38	Deciphering the serological response to syphilis treatment in men living with HIV. ⁶¹	Ren M...Walmsley SL	32773482	2020
39	Secondary Syphilis. ⁶¹	Ehlers S...Ashurst J	33217306	2020
40	Secondary syphilis mimicking sarcoidosis. ⁶¹	Li W...Palavecino E	33235767	2020
41	A case of lichenoid mycosis fungoides that became apparent after penicillin treatment for secondary syphilis. ⁶¹	Akdogan N...Ersoy-Evans S	32643226	2020
42	Diphasic fever with generalised rash including palm and sole: secondary syphilis and HIV coinfection. ⁶¹	Yoshikawa H...Ikusaka M	33122235	2020
43	Risk Factors for the Co-infection with HIV, Hepatitis B and C Virus in Syphilis Patients. ⁶¹	Gong HZ...Li J	33026095	2020
44	Don't forget about syphilis: sexually transmitted diseases during COVID-19 pandemic. ⁶¹	Di Buduo A...Ferreli C	33437752	2020
45	A new specimen for syphilis diagnosis: Evidence by high loads of Treponema pallidum DNA in saliva. ⁶¹	Wang C...Zhou P	33099614	2020
46	Cutaneous Secondary Syphilis Resembling Non-Melanoma Skin Cancer. ⁶¹	Stone CE...Jukic D	33033668	2020
47	Secondary Syphilis. ⁶¹	Bhugra P...Maiti A	32997911	2020
48	Estimation of Full-Length TprK Diversity in Treponema pallidum subsp. pallidum. ⁶¹	Addetia A...Greninger AL	33109767	2020
49	Tinidazole: Another Therapeutic Option for Syphilis? ⁶¹	Drago F...Parodi A	32408379	2020
50	Police killings of Black people and rates of sexually transmitted infections: a cross-sectional analysis of 75 large US metropolitan areas, 2016. ⁶¹	Ibragimov U...Cooper HL	31444277	2020

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Genes for Secondary Syphilis

Genes related to Secondary Syphilis (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CD209	CD209 Molecule	Protein Coding	11.67	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	FN1	Fibronectin 1	Protein Coding	11.43	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	TPR	Translocated Promoter Region, Nuclear Basket Protein	Protein Coding	7.51	DISEASES inferred ¹⁵
4	CD4	CD4 Molecule	Protein Coding	7.13	DISEASES inferred ¹⁵
5	POLA1	DNA Polymerase Alpha 1, Catalytic Subunit	Protein Coding	6.82	DISEASES inferred ¹⁵
6	CD40LG	CD40 Ligand	Protein Coding	6.77	GeneCards inferred via : Publications (show sections)
7	CD79A	CD79a Molecule	Protein Coding	6.77	GeneCards inferred via : Publications (show sections)
8	CD8A	CD8a Molecule	Protein Coding	5.7	DISEASES inferred ¹⁵
9	EPB41L3	Erythrocyte Membrane Protein Band 4.1 Like 3	Protein Coding	5.44	DISEASES inferred ¹⁵
10	CRP	C-Reactive Protein	Protein Coding	5.31	DISEASES inferred ¹⁵
11	CCR5	C-C Motif Chemokine Receptor 5	Protein Coding	5.28	DISEASES inferred ¹⁵
12	CXCL13	C-X-C Motif Chemokine Ligand 13	Protein Coding	5.2	DISEASES inferred ¹⁵

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Variations for Secondary Syphilis

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Expression for Secondary Syphilis

Search GEO for disease gene expression data for Secondary Syphilis.

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Pathways for Secondary Syphilis

Pathways related to Secondary Syphilis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.5	TPR FN1 CRP CD8A CD79A CD40LG
2	Allograft rejection ³⁶ ¹ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.52	CXCL13 CD8A CD40LG CD4
3	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.16	CD8A CD40LG CD4 CCR5
4	Cell adhesion molecules ³⁶	11.81	CD8A CD40LG CD4
5	Yersinia infection ³⁶	11.72	FN1 CD8A CD4
6	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²³	11.6	CD8A CD4 CCR5
7	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.32	CD8A CD79A CD4 CD209
8	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.2	CD8A CD4 CD209
9	Overview of nanoparticle effects ¹	10.71	FN1 CRP
10	Primary immunodeficiency ³⁶	10.5	CD8A CD79A CD40LG CD4

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GO Terms for Secondary Syphilis

Cellular components related to Secondary Syphilis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	9.1	CD8A CD79A CD40LG CD4 CD209 CCR5

Biological processes related to Secondary Syphilis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	adaptive immune response	GO:0002250	9.71	CD8A CD79A CD4 CD209
2	inflammatory response	GO:0006954	9.67	CXCL13 CRP CD40LG CCR5
3	viral process	GO:0016032	9.65	TPR POLA1 CD4 CD209 CCR5
4	immune response	GO:0006955	9.35	CXCL13 CD8A CD40LG CD4 CCR5
5	positive regulation of T cell proliferation	GO:0042102	9.33	CD40LG CD4 CD209
6	fusion of virus membrane with host plasma membrane	GO:0019064	9.32	CD4 CCR5
7	cell surface receptor signaling pathway	GO:0007166	9.02	CXCL13 CD8A CD79A CD4 CCR5

Molecular functions related to Secondary Syphilis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	virion binding	GO:0046790	9.16	CRP CD209
2	virus receptor activity	GO:0001618	9.13	CD4 CD209 CCR5
3	coreceptor activity	GO:0015026	8.8	CD8A CD4 CCR5

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Sources for Secondary Syphilis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia