MCID: SCN006
MIFTS: 36

Secondary Syphilis

Categories: Bone diseases, Fetal diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Secondary Syphilis

MalaCards integrated aliases for Secondary Syphilis:

Name: Secondary Syphilis 12 15
Syphilis, Secondary 44 70
Secondary Syphilis of Viscera or Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4157
ICD9CM 34 091.9
MeSH 44 C536773
NCIt 50 C128413
SNOMED-CT 67 154382002
UMLS 70 C0149985

Summaries for Secondary Syphilis

Disease Ontology : 12 A syphilis that is characterized as the second stage of syphilis which appears from 2 to 6 months after primary infection, and is marked by lesions especially in the skin but also in organs and tissues, and that lasts from 3 to 12 weeks.

MalaCards based summary : Secondary Syphilis, also known as syphilis, secondary, is related to asymptomatic neurosyphilis and exanthem. An important gene associated with Secondary Syphilis is CD209 (CD209 Molecule), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. Affiliated tissues include skin, bone and lung.

Related Diseases for Secondary Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Secondary Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 510)
# Related Disease Score Top Affiliating Genes
1 asymptomatic neurosyphilis 31.9 CXCL13 CD4
2 exanthem 30.9 CRP CD8A CD4
3 congenital syphilis 30.8 TPR POLA1 EPB41L3 CD79A CD40LG CD4
4 glomerulonephritis 30.6 FN1 CD79A CD40LG
5 leprosy 3 30.5 CD8A CD4 CD209
6 iridocyclitis 30.4 CRP CD4
7 neuroretinitis 30.3 CRP CD4
8 bell's palsy 30.3 CD8A CD4
9 optic papillitis 30.3 CRP CD4
10 tenosynovitis 30.3 CRP CD4
11 bone inflammation disease 30.2 CRP CD8A CD4
12 aortitis 30.2 CRP CD4
13 sporotrichosis 30.1 CD79A CD40LG CD4
14 chorioretinitis 30.1 CRP CD8A CD4
15 lung abscess 30.1 CRP CD4
16 yaws 30.0 TPR POLA1 EPB41L3
17 facial paralysis 30.0 CRP CD8A CD4
18 oral hairy leukoplakia 30.0 CD8A CD4
19 granulomatous dermatitis 30.0 CD8A CD4
20 vasculitis 29.9 CRP CD79A CD40LG
21 granulomatous hepatitis 29.9 CRP CD8A CD4
22 lymphadenitis 29.9 CRP CD4 CD209
23 alopecia universalis congenita 29.9 CD8A CD4
24 primary syphilis 29.9 TPR POLA1 CRP CD8A CD4
25 syphilis 29.8 TPR POLA1 FN1 CRP CD8A CD79A
26 early yaws 29.8 TPR CD8A CD4
27 iritis 29.8 CRP CD8A CD4
28 chickenpox 29.7 CRP CD8A CD4
29 pharyngitis 29.7 CRP CD8A CD4
30 panuveitis 29.7 CRP CD8A CD4
31 pfeiffer syndrome 29.7 CD8A CD40LG CD4
32 sarcoidosis 1 29.6 CRP CD8A CD4 CCR5
33 skin disease 29.6 CRP CD8A CD79A CD4
34 tertiary syphilis 29.6 TPR CXCL13 CRP CD8A CD4
35 fungal infectious disease 29.5 CRP CD8A CD4 CD209
36 severe cutaneous adverse reaction 29.5 CRP CD8A CD4
37 syphilitic meningitis 29.5 CXCL13 CRP CD8A CD4
38 latent syphilis 29.4 TPR POLA1 CXCL13 CD8A CD4
39 parotitis 29.3 CRP CD8A CD79A CD4
40 autoimmune disease 29.3 CRP CD79A CD40LG CCR5
41 disease by infectious agent 29.2 CRP CD8A CD4 CD209 CCR5
42 acquired immunodeficiency syndrome 29.2 CRP CD79A CD40LG CD4 CCR5
43 human immunodeficiency virus infectious disease 29.1 CD8A CD79A CD4 CD209 CCR5
44 immune deficiency disease 28.7 FN1 CRP CD8A CD79A CD40LG CD4
45 inflammatory bowel disease 28.6 CRP CD8A CD40LG CD209 CCR5
46 systemic lupus erythematosus 28.2 CXCL13 CRP CD79A CD40LG CD4 CCR5
47 nephrotic syndrome 10.5
48 alopecia 10.5
49 neurosyphilis 10.4
50 hemorrhagic fever-renal syndrome 10.4 CD79A CD40LG

Graphical network of the top 20 diseases related to Secondary Syphilis:



Diseases related to Secondary Syphilis

Symptoms & Phenotypes for Secondary Syphilis

Drugs & Therapeutics for Secondary Syphilis

Search Clinical Trials , NIH Clinical Center for Secondary Syphilis

Cochrane evidence based reviews: syphilis, secondary

Genetic Tests for Secondary Syphilis

Anatomical Context for Secondary Syphilis

MalaCards organs/tissues related to Secondary Syphilis:

40
Skin, Bone, Lung, Tongue, Eye, Lymph Node, Myeloid

Publications for Secondary Syphilis

Articles related to Secondary Syphilis:

(show top 50) (show all 1729)
# Title Authors PMID Year
1
Condyloma lata in secondary syphilis. 61
33732839 2021
2
Cerebral syphilitic gumma presenting with intracranial gumma and pathologic vertebrae fractures. 61
33613804 2021
3
A unique presentation of papulonodular secondary syphilis in an elderly patient. 61
33763862 2021
4
Scrotal plaques as a predominant presentation in a case of secondary syphilis. 61
33769741 2021
5
When hair loss is not just a cosmetic problem: Moth-eaten alopecia in secondary syphilis. 61
33768667 2021
6
Oral manifestations of syphilis: an epidemiological study in southern Brazil. 61
33656756 2021
7
Secondary syphilis presenting as oral ulcers. 61
31900252 2021
8
Secondary Syphilis With Elastophagocytosis: An Unusual Histologic Finding. 61
33298710 2021
9
Malignant Syphilis: A Systematic Review of the Case Reports Published in 2014-2018. 61
33811833 2021
10
Pigtail hairs in syphilitic alopecia. 61
33783889 2021
11
Cauliflower-shaped lesions on a young woman's vulva. 61
33533298 2021
12
Clinical presentation of incident syphilis among men who have sex with men taking HIV Pre-Exposure Prophylaxis in Melbourne, Australia. 61
33522575 2021
13
A Case of Rapidly Proliferative Glomerulonephritis Secondary to Syphilis That Responded to Treatment With Penicillin. 61
33777557 2021
14
A case of macular rash misleading to drug eruption in secondary syphilis. 61
33219710 2021
15
Secondary syphilis with liver involvement in a liver transplant recipient. 61
32738832 2021
16
The impact of the SARS-CoV-2 pandemic on HIV and bacterial sexually transmitted infection testing and diagnosis in Oregon. 61
33534405 2021
17
Syphilitic Pulmonary Inflammatory Pseudotumor: A Diagnostic Challenge. 61
32486870 2021
18
Clinical outcomes of syphilis in HIV-negative and HIV-positive MSM: occurrence of repeat syphilis episodes and non-treponemal serology responses. 61
33608479 2021
19
Oral forms of secondary syphilis: An illustration of the pitfalls set by the great imitator. 61
32339705 2021
20
An Investigation of Early Syphilis Among Men Who have Sex with Men: Alaska, 2018: Findings from a 2018 Rapid Ethnographic Assessment. 61
32410089 2021
21
An unusual case of oral condyloma lata. 61
33607303 2021
22
Azithromycin resistance in Treponema pallidum in Reunion Island: A cross-sectional study. 61
33608114 2021
23
Secondary syphilis with alopecia and ocular manifestation. 61
33423955 2021
24
Serological diagnosis of secondary syphilis in a Rituximab-treated patient: an emerging diagnostic challenge? 61
33462864 2021
25
Oral Manifestations of Syphilis: a Review of the Clinical and Histopathologic Characteristics of a Reemerging Entity with Report of 19 New Cases. 61
33459991 2021
26
Jarisch-Herxheimer Reaction After Cephalosporin Administration in Syphilis. 61
33643725 2021
27
Rectal cancer mimic: a rare case of syphilitic proctitis. 61
33370929 2020
28
An unusual case of secondary syphilis misdiagnosed as allergic dermatitis for 2 years. 61
33363789 2020
29
Sporotrichoid secondary syphilis. 61
33314047 2020
30
Oral Lesions as the Only Manifestation of Secondary Syphilis. 61
32679120 2020
31
Do not miss secondary syphilis: examine the palms and soles. 61
33234557 2020
32
Annular and arciform lesions of the palms as unique manifestations of secondary syphilis. 61
32981425 2020
33
Visual Dermatology: Overlapping Primary and Secondary Syphilis Mimicking Penile Carcinoma. 61
32716635 2020
34
The challenging diagnosis of overlapping oral primary/secondary syphilis with nonreactive serology. 61
32666536 2020
35
Kidney disease in secondary syphilis: a case report. 61
33168357 2020
36
Management of syphilitic hepatitis. 61
33183229 2020
37
Nowcasting Sexually Transmitted Infections in Chicago: Predictive Modeling and Evaluation Study Using Google Trends. 61
33151162 2020
38
Deciphering the serological response to syphilis treatment in men living with HIV. 61
32773482 2020
39
Secondary Syphilis. 61
33217306 2020
40
Secondary syphilis mimicking sarcoidosis. 61
33235767 2020
41
A case of lichenoid mycosis fungoides that became apparent after penicillin treatment for secondary syphilis. 61
32643226 2020
42
Diphasic fever with generalised rash including palm and sole: secondary syphilis and HIV coinfection. 61
33122235 2020
43
Risk Factors for the Co-infection with HIV, Hepatitis B and C Virus in Syphilis Patients. 61
33026095 2020
44
Don't forget about syphilis: sexually transmitted diseases during COVID-19 pandemic. 61
33437752 2020
45
A new specimen for syphilis diagnosis: Evidence by high loads of Treponema pallidum DNA in saliva. 61
33099614 2020
46
Cutaneous Secondary Syphilis Resembling Non-Melanoma Skin Cancer. 61
33033668 2020
47
Secondary Syphilis. 61
32997911 2020
48
Estimation of Full-Length TprK Diversity in Treponema pallidum subsp. pallidum. 61
33109767 2020
49
Tinidazole: Another Therapeutic Option for Syphilis? 61
32408379 2020
50
Police killings of Black people and rates of sexually transmitted infections: a cross-sectional analysis of 75 large US metropolitan areas, 2016. 61
31444277 2020

Variations for Secondary Syphilis

Expression for Secondary Syphilis

Search GEO for disease gene expression data for Secondary Syphilis.

Pathways for Secondary Syphilis

GO Terms for Secondary Syphilis

Cellular components related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.1 CD8A CD79A CD40LG CD4 CD209 CCR5

Biological processes related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.71 CD8A CD79A CD4 CD209
2 inflammatory response GO:0006954 9.67 CXCL13 CRP CD40LG CCR5
3 viral process GO:0016032 9.65 TPR POLA1 CD4 CD209 CCR5
4 immune response GO:0006955 9.35 CXCL13 CD8A CD40LG CD4 CCR5
5 positive regulation of T cell proliferation GO:0042102 9.33 CD40LG CD4 CD209
6 fusion of virus membrane with host plasma membrane GO:0019064 9.32 CD4 CCR5
7 cell surface receptor signaling pathway GO:0007166 9.02 CXCL13 CD8A CD79A CD4 CCR5

Molecular functions related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virion binding GO:0046790 9.16 CRP CD209
2 virus receptor activity GO:0001618 9.13 CD4 CD209 CCR5
3 coreceptor activity GO:0015026 8.8 CD8A CD4 CCR5

Sources for Secondary Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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