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MCID: SCN006
MIFTS: 39

Secondary Syphilis

Categories: Bone diseases, Fetal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Secondary Syphilis

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MalaCards integrated aliases for Secondary Syphilis:

Name: Secondary Syphilis 12 15
Syphilis, Secondary 45 74
Secondary Syphilis of Viscera or Bone 12

Classifications:

MalaCards categories:
Global: Infectious diseases Fetal diseases Rare diseases
Anatomical: Bone diseases Neuronal diseases Skin diseases Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4157
ICD9CM 36 091.9
MeSH 45 C536773
NCIt 51 C128413
UMLS 74 C0149985
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Summaries for Secondary Syphilis

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Disease Ontology : 12 A syphilis that is characterized as the second stage of syphilis which appears from 2 to 6 months after primary infection, and is marked by lesions especially in the skin but also in organs and tissues, and that lasts from 3 to 12 weeks.

MalaCards based summary : Secondary Syphilis, also known as syphilis, secondary, is related to asymptomatic neurosyphilis and syphilis. An important gene associated with Secondary Syphilis is FN1 (Fibronectin 1), and among its related pathways/superpathways are Primary immunodeficiency and Inflammatory Response Pathway. The drugs Penicillin G and Procaine have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes.

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Related Diseases for Secondary Syphilis

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Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Secondary Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 asymptomatic neurosyphilis 31.5 DDX41 EXTL3
2 syphilis 30.8 CD209 CD40LG CD79A DDX41 EXTL3 POLA1
3 congenital syphilis 30.2 CD40LG CD79A DDX41 EXTL3 POLA1
4 sporotrichosis 30.0 CD40LG CD79A
5 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 29.4 CD209 CD40LG
6 tertiary syphilis 29.4 DDX41 EXTL3
7 hepatitis 10.4
8 nephrotic syndrome 10.2
9 c1q nephropathy 10.2 CD40LG CD79A
10 immunoglobulin g deficiency 10.2 CD40LG CD79A
11 heparin-induced thrombocytopenia 10.2 CD40LG CD79A
12 immunoglobulin a deficiency 1 10.2 CD40LG CD79A
13 immunodeficiency-centromeric instability-facial anomalies syndrome 1 10.2 CD40LG CD79A
14 ocular toxoplasmosis 10.2 CD40LG CD79A
15 toxoplasmosis 10.2 CD40LG CD79A
16 persistent generalized lymphadenopathy 10.2 CD40LG CD79A
17 alopecia 10.2
18 immunodeficiency with hyper-igm, type 1 10.1 CD40LG CD79A
19 hemorrhagic fever 10.1 CD209 CD40LG
20 congenital toxoplasmosis 10.1 CD40LG CD79A
21 immunoglobulin alpha deficiency 10.1 CD40LG CD79A
22 cryptosporidiosis 10.1 CD40LG CD79A
23 lymphoma 10.1
24 human immunodeficiency virus infectious disease 10.1
25 pustulosis palmaris et plantaris 10.1 CD40LG CD79A
26 dysgerminoma of ovary 10.1 CD40LG CD79A
27 dengue disease 10.1 CD209 CD40LG
28 marginal zone b-cell lymphoma 10.1 CD40LG CD79A
29 agammaglobulinemia, x-linked 10.1 CD40LG CD79A
30 meningoencephalitis 10.1 CD40LG CD79A
31 erythema multiforme 10.1
32 gastritis 10.1
33 psoriasis 10.1
34 cryoglobulinemia 10.0 CD40LG CD79A
35 arthritis 10.0
36 lichen planus 10.0
37 cryofibrinogenemia 10.0 CD40LG CD79A FN1
38 immune deficiency disease 10.0 CD40LG CD79A
39 iga glomerulonephritis 9.9 CD40LG CD79A
40 kaposi sarcoma 9.9
41 glomerulonephritis 9.9
42 sarcoma 9.9
43 uveitis 9.9
44 lupus erythematosus 9.9
45 chorioretinitis 9.9
46 meningitis 9.9
47 periostitis 9.9
48 pityriasis lichenoides 9.9
49 late congenital syphilis 9.9 DDX41 EXTL3
50 immunodeficiency 17 9.9 CD40LG DDX41

Graphical network of the top 20 diseases related to Secondary Syphilis:



Diseases related to Secondary Syphilis
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Symptoms & Phenotypes for Secondary Syphilis

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Drugs & Therapeutics for Secondary Syphilis

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Drugs for Secondary Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
2
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
3 Anti-Bacterial Agents Phase 4
4 Penicillin G Benzathine Phase 4
5 Anti-Infective Agents Phase 4
6 penicillins Phase 4
7 Penicillin G Procaine Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
2 Comparisons of Serologic Response of Early Syphilis Completed NCT01944358
3 Penicillin Therapeutic Drug Monitoring in the Treatment of Infectious Syphilis. Terminated NCT01540227 Regular Treatment for Syphilis

Search NIH Clinical Center for Secondary Syphilis

Cochrane evidence based reviews: syphilis, secondary

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Genetic Tests for Secondary Syphilis

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Anatomical Context for Secondary Syphilis

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MalaCards organs/tissues related to Secondary Syphilis:

42
Skin, Bone, Testes, Tonsil, Tongue, T Cells, Lymph Node
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Publications for Secondary Syphilis

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Articles related to Secondary Syphilis:

(show top 50) (show all 667)
# Title Authors Year
1
Moth-eaten Alopecia in secondary syphilis. ( 30807867 )
2019
2
Annular secondary syphilis. ( 30616335 )
2019
3
Rounded atrophic areas on the dorsum of the tongue: plaques en prairie fauchée of secondary syphilis. ( 30622897 )
2019
4
Nodulo-ulcerative and erythrodermic secondary syphilis in human immunodeficiency virus-infected individuals. ( 30630397 )
2019
5
Vegetating lesions in secondary syphilis. ( 30748034 )
2019
6
Increased Methamphetamine, Injection Drug, and Heroin Use Among Women and Heterosexual Men with Primary and Secondary Syphilis - United States, 2013-2017. ( 30763294 )
2019
7
Lichenoid skin lesions: A rare manifestation in secondary syphilis. ( 30785122 )
2019
8
Geographic correlates of primary and secondary syphilis among men who have sex with men in the United States. ( 30799206 )
2019
9
Dermoscopic clues in the skin lesions of secondary syphilis. ( 30899465 )
2019
10
A case of secondary syphilis with pulmonary involvement and review of the literature. ( 29621949 )
2018
11
Oral findings in secondary syphilis. ( 29476680 )
2018
12
Secondary syphilis: an atypical presentation complicated by a false negative rapid plasma reagin test. ( 29894545 )
2018
13
Secondary syphilis: lest we forget it. ( 29545459 )
2018
14
Cross-sectional study of Treponema pallidum PCR in diagnosis of primary and secondary syphilis. ( 29090453 )
2018
15
Rare Case of Four Osseous Lesions of the Skull in a Patient with Secondary Syphilis. ( 29854502 )
2018
16
Secondary Syphilis with Tonsillar and Cervical Lymphadenopathy and a Pulmonary Lesion Mimicking Malignant Lymphoma. ( 29502129 )
2018
17
Annular and arcuate syphilis: an uncommon presentation of disseminated secondary syphilis. ( 29906011 )
2018
18
An Emergency Department Presentation of Secondary Syphilis. ( 29547908 )
2018
19
Primary and Secondary Syphilis as Chancre of the Mouth with Rash. ( 29033418 )
2018
20
Secondary Syphilis Mimicking Giant Cell Arteritis. ( 29561471 )
2018
21
Secondary Syphilis Without Any History of Primary Infection. ( 29366456 )
2018
22
Fulminant hepatitis in a patient with secondary syphilis. ( 29979145 )
2018
23
Secondary Syphilis with Pulmonary Involvement. ( 29021433 )
2018
24
Syphilitic gastritis: a rare presentation of secondary syphilis. ( 29523617 )
2018
25
A secondary syphilis rash with scaly target lesions. ( 29410787 )
2018
26
Mucocutaneous Secondary Syphilis: 'The Great Imitator'. ( 29079400 )
2018
27
Reported Primary and Secondary Syphilis Cases in the United States: Implications for HIV Infection. ( 29465633 )
2018
28
Differences in Partner Services Outcomes for Men Who Have Sex With Men Diagnosed With Primary and Secondary Syphilis by HIV Serostatus. ( 29420442 )
2018
29
A Young Boy with Persistent Nodules and Hoarseness: A Rare Presentation of Nodular Secondary Syphilis. ( 29482701 )
2018
30
Secondary syphilis presenting as erythema multiforme in a HIV-positive homosexual man: a case report and literature review. ( 30482099 )
2018
31
Secondary syphilis presented with impetigo-like lesions: a rare case report. ( 30094832 )
2018
32
Unusual Manifestations of Secondary Syphilis: Case Presentations. ( 29989879 )
2018
33
Oral ulcers as a presentation of secondary syphilis. ( 30039628 )
2018
34
The disappearance of femoral head and neck resulting from extensive bone defect caused by secondary syphilis: a case report and literature review. ( 30045704 )
2018
35
An unusual giant serpiginous lesion of secondary syphilis. ( 30066774 )
2018
36
Secondary syphilis presenting as a corymbiform syphilide: case report and review. ( 30133600 )
2018
37
Secondary syphilis masquerading as lupus vulgaris in an HIV-infected patient: A diagnosis suggested by histology. ( 30170530 )
2018
38
Altered Appearance of Secondary Syphilis Rash Within a Pre-Existing Tattoo. ( 30363028 )
2018
39
Treponema Pallidum Epidermotropism in Nodular Secondary Syphilis. ( 30504982 )
2018
40
Image Gallery: Moth-eaten alopecia as the only cutaneous symptom of acquired secondary syphilis in a 2-year-old boy. ( 29192994 )
2017
41
Fetal response to intramuscular epinephrine for anaphylaxis during maternal penicillin desensitization for secondary syphilis. ( 28562129 )
2017
42
Papulonodular Secondary Syphilis Presenting as Multiple Distinct Cutaneous Lesions in an HIV-Positive Transgender Woman. ( 28512403 )
2017
43
Anetoderma due to secondary syphilis: Report of two cases and discussion of the histopathological findings. ( 28571518 )
2017
44
Secondary syphilis presenting as leucoderma syphiliticum: case report and review. ( 29116294 )
2017
45
Secondary syphilis-related oral mucous patches. ( 28593145 )
2017
46
Stevens Johnson Syndrome versus Jarisch Herxheimer Reaction in an HIV Positive Patient with Secondary Syphilis. ( 29076438 )
2017
47
Development and Evaluation of a Loop-Mediated Isothermal Amplification Assay for the Detection of<i>Treponema pallidum</i>DNA in the Peripheral Blood of Secondary Syphilis Patients. ( 29016285 )
2017
48
Brief report: Use of ICD-10 code A51.31 (condyloma latum) for identifying cases of secondary syphilis. ( 28953413 )
2017
49
Rates of Primary and Secondary Syphilis Among White and Black non-Hispanic Men Who Have Sex with Men, US States, 2014. ( 28749823 )
2017
50
Ocular involvement with secondary syphilis in a non-HIV infected man. ( 28840111 )
2017
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Variations for Secondary Syphilis

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Expression for Secondary Syphilis

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Search GEO for disease gene expression data for Secondary Syphilis.
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Pathways for Secondary Syphilis

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Pathways related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Primary immunodeficiency 38
10.52 CD40LG CD79A
2
Inflammatory Response Pathway 1
10.14 CD40LG FN1
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GO Terms for Secondary Syphilis

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Cellular components related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD209 CD40LG CD79A

Biological processes related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 9.26 CD40LG CD79A
2 positive regulation of T cell proliferation GO:0042102 9.16 CD209 CD40LG
3 B cell proliferation GO:0042100 8.96 CD40LG CD79A
4 leukocyte cell-cell adhesion GO:0007159 8.62 CD209 CD40LG
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Sources for Secondary Syphilis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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