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MCID: SCN006
MIFTS: 40

Secondary Syphilis

Categories: Bone diseases, Fetal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Secondary Syphilis

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MalaCards integrated aliases for Secondary Syphilis:

Name: Secondary Syphilis 12 15
Syphilis, Secondary 44 73
Secondary Syphilis of Viscera or Bone 12

Classifications:

MalaCards categories:
Global: Infectious diseases Fetal diseases Rare diseases
Anatomical: Bone diseases Neuronal diseases Skin diseases Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4157
ICD9CM 35 091.9
MeSH 44 C536773
NCIt 50 C128413
UMLS 73 C0149985
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Summaries for Secondary Syphilis

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Disease Ontology : 12 A syphilis that is characterized as the second stage of syphilis which appears from 2 to 6 months after primary infection, and is marked by lesions especially in the skin but also in organs and tissues, and that lasts from 3 to 12 weeks.

MalaCards based summary : Secondary Syphilis, also known as syphilis, secondary, is related to asymptomatic neurosyphilis and syphilis. An important gene associated with Secondary Syphilis is CD209 (CD209 Molecule), and among its related pathways/superpathways are Innate Immune System and Primary immunodeficiency. The drugs Procaine and Penicillin G have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and liver.

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Related Diseases for Secondary Syphilis

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Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Secondary Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
# Related Disease Score Top Affiliating Genes
1 asymptomatic neurosyphilis 31.7 DDX41 EXTL3
2 syphilis 31.2 CD209 CD40LG CD79A DDX41 EXTL3 POLA1
3 congenital syphilis 30.8 CD40LG CD79A DDX41 EXTL3 POLA1
4 sporotrichosis 30.0 CD40LG CD79A
5 yaws 29.6 EXTL3 TPR
6 hepatitis 10.4
7 nephrotic syndrome 10.2
8 c1q nephropathy 10.2 CD40LG CD79A
9 immunoglobulin g deficiency 10.2 CD40LG CD79A
10 heparin-induced thrombocytopenia 10.1 CD40LG CD79A
11 immunoglobulin a deficiency 1 10.1 CD40LG CD79A
12 immunodeficiency-centromeric instability-facial anomalies syndrome 1 10.1 CD40LG CD79A
13 ocular toxoplasmosis 10.1 CD40LG CD79A
14 toxoplasmosis 10.1 CD40LG CD79A
15 persistent generalized lymphadenopathy 10.1 CD40LG CD79A
16 immunodeficiency with hyper-igm, type 1 10.1 CD40LG CD79A
17 hemorrhagic fever 10.1 CD209 CD40LG
18 congenital toxoplasmosis 10.1 CD40LG CD79A
19 immunoglobulin alpha deficiency 10.1 CD40LG CD79A
20 cryptosporidiosis 10.1 CD40LG CD79A
21 alopecia 10.1
22 lymphoma 10.1
23 human immunodeficiency virus infectious disease 10.1
24 pustulosis palmaris et plantaris 10.1 CD40LG CD79A
25 dengue disease 10.1 CD209 CD40LG
26 dysgerminoma of ovary 10.1 CD40LG CD79A
27 marginal zone b-cell lymphoma 10.1 CD40LG CD79A
28 meningoencephalitis 10.1 CD40LG CD79A
29 cryoglobulinemia 10.1 CD40LG CD79A
30 viral infectious disease 10.1
31 agammaglobulinemia, x-linked 10.1 CD40LG CD79A
32 immunodeficiency 17 10.1 CD40LG DDX41
33 late congenital syphilis 10.1 DDX41 EXTL3
34 immune deficiency disease 10.1 CD40LG CD79A
35 tertiary syphilis 10.1 DDX41 EXTL3
36 erythema multiforme 10.0
37 gastritis 10.0
38 psoriasis 10.0
39 iga glomerulonephritis 10.0 CD40LG CD79A
40 tabes dorsalis 10.0 DDX41 EXTL3
41 autoimmune disease of musculoskeletal system 10.0 CD40LG DDX41
42 tertiary neurosyphilis 10.0 DDX41 EXTL3
43 arthritis 10.0
44 lichen planus 10.0
45 cryofibrinogenemia 10.0 CD40LG CD79A FN1
46 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.0 CD209 CD40LG
47 immune system disease 10.0 CD40LG DDX41
48 primary bacterial infectious disease 10.0 DDX41 EXTL3
49 kaposi sarcoma 9.9
50 glomerulonephritis 9.9

Graphical network of the top 20 diseases related to Secondary Syphilis:



Diseases related to Secondary Syphilis
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Symptoms & Phenotypes for Secondary Syphilis

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Drugs & Therapeutics for Secondary Syphilis

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Drugs for Secondary Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
2
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
3 Penicillin G Benzathine Phase 4
4 penicillins Phase 4
5 Anti-Bacterial Agents Phase 4
6 Anti-Infective Agents Phase 4
7 Penicillin G Procaine Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
2 Comparisons of Serologic Response of Early Syphilis Completed NCT01944358
3 Penicillin Therapeutic Drug Monitoring in the Treatment of Infectious Syphilis. Terminated NCT01540227 Regular Treatment for Syphilis

Search NIH Clinical Center for Secondary Syphilis

Cochrane evidence based reviews: syphilis, secondary

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Genetic Tests for Secondary Syphilis

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Anatomical Context for Secondary Syphilis

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MalaCards organs/tissues related to Secondary Syphilis:

41
Skin, Bone, Liver, Testes, Tonsil, T Cells, Thyroid
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Publications for Secondary Syphilis

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Articles related to Secondary Syphilis:

(show top 50) (show all 657)
# Title Authors Year
1
A case of secondary syphilis with pulmonary involvement and review of the literature. ( 29621949 )
2018
2
Oral findings in secondary syphilis. ( 29476680 )
2018
3
Secondary syphilis: an atypical presentation complicated by a false negative rapid plasma reagin test. ( 29894545 )
2018
4
Secondary syphilis: lest we forget it. ( 29545459 )
2018
5
Cross-sectional study of Treponema pallidum PCR in diagnosis of primary and secondary syphilis. ( 29090453 )
2018
6
Rare Case of Four Osseous Lesions of the Skull in a Patient with Secondary Syphilis. ( 29854502 )
2018
7
Secondary Syphilis with Tonsillar and Cervical Lymphadenopathy and a Pulmonary Lesion Mimicking Malignant Lymphoma. ( 29502129 )
2018
8
Annular and arcuate syphilis: an uncommon presentation of disseminated secondary syphilis. ( 29906011 )
2018
9
An Emergency Department Presentation of Secondary Syphilis. ( 29547908 )
2018
10
Primary and Secondary Syphilis as Chancre of the Mouth with Rash. ( 29033418 )
2018
11
Secondary Syphilis Mimicking Giant Cell Arteritis. ( 29561471 )
2018
12
Secondary Syphilis Without Any History of Primary Infection. ( 29366456 )
2018
13
Fulminant hepatitis in a patient with secondary syphilis. ( 29979145 )
2018
14
Secondary Syphilis with Pulmonary Involvement. ( 29021433 )
2018
15
Syphilitic gastritis: a rare presentation of secondary syphilis. ( 29523617 )
2018
16
A secondary syphilis rash with scaly target lesions. ( 29410787 )
2018
17
Mucocutaneous Secondary Syphilis: 'The Great Imitator'. ( 29079400 )
2018
18
Reported Primary and Secondary Syphilis Cases in the United States: Implications for HIV Infection. ( 29465633 )
2018
19
Differences in Partner Services Outcomes for Men Who Have Sex With Men Diagnosed With Primary and Secondary Syphilis by HIV Serostatus. ( 29420442 )
2018
20
A Young Boy with Persistent Nodules and Hoarseness: A Rare Presentation of Nodular Secondary Syphilis. ( 29482701 )
2018
21
Secondary syphilis presenting as erythema multiforme in a HIV-positive homosexual man: a case report and literature review. ( 30482099 )
2018
22
Secondary syphilis presented with impetigo-like lesions: a rare case report. ( 30094832 )
2018
23
Unusual Manifestations of Secondary Syphilis: Case Presentations. ( 29989879 )
2018
24
Oral ulcers as a presentation of secondary syphilis. ( 30039628 )
2018
25
The disappearance of femoral head and neck resulting from extensive bone defect caused by secondary syphilis: a case report and literature review. ( 30045704 )
2018
26
An unusual giant serpiginous lesion of secondary syphilis. ( 30066774 )
2018
27
Secondary syphilis presenting as a corymbiform syphilide: case report and review. ( 30133600 )
2018
28
Secondary syphilis masquerading as lupus vulgaris in an HIV-infected patient: A diagnosis suggested by histology. ( 30170530 )
2018
29
Altered Appearance of Secondary Syphilis Rash Within a Pre-Existing Tattoo. ( 30363028 )
2018
30
Treponema Pallidum Epidermotropism in Nodular Secondary Syphilis. ( 30504982 )
2018
31
Image Gallery: Moth-eaten alopecia as the only cutaneous symptom of acquired secondary syphilis in a 2-year-old boy. ( 29192994 )
2017
32
Fetal response to intramuscular epinephrine for anaphylaxis during maternal penicillin desensitization for secondary syphilis. ( 28562129 )
2017
33
Papulonodular Secondary Syphilis Presenting as Multiple Distinct Cutaneous Lesions in an HIV-Positive Transgender Woman. ( 28512403 )
2017
34
Anetoderma due to secondary syphilis: Report of two cases and discussion of the histopathological findings. ( 28571518 )
2017
35
Secondary syphilis presenting as leucoderma syphiliticum: case report and review. ( 29116294 )
2017
36
Secondary syphilis-related oral mucous patches. ( 28593145 )
2017
37
Stevens Johnson Syndrome versus Jarisch Herxheimer Reaction in an HIV Positive Patient with Secondary Syphilis. ( 29076438 )
2017
38
Development and Evaluation of a Loop-Mediated Isothermal Amplification Assay for the Detection of<i>Treponema pallidum</i>DNA in the Peripheral Blood of Secondary Syphilis Patients. ( 29016285 )
2017
39
Brief report: Use of ICD-10 code A51.31 (condyloma latum) for identifying cases of secondary syphilis. ( 28953413 )
2017
40
Rates of Primary and Secondary Syphilis Among White and Black non-Hispanic Men Who Have Sex with Men, US States, 2014. ( 28749823 )
2017
41
Ocular involvement with secondary syphilis in a non-HIV infected man. ( 28840111 )
2017
42
New imaging tools for an old disease: Secondary syphilis. ( 28718501 )
2017
43
Secondary Syphilis Presenting As Palmoplantar Psoriasis. ( 28785328 )
2017
44
Pulmonary involvement of secondary syphilis. ( 28661232 )
2017
45
Secondary Syphilis Presenting as Glossodynia, Plaques en Prairie FauchAce, and a Split Papule at the Oral Commissure: Case Report and Review. ( 28785283 )
2017
46
Unusual presentation of secondary syphilis: membranoproliferative glomerulonephritis andmuco-cutaneous lesions. ( 28950764 )
2017
47
Secondary syphilis primarily presenting with multiple nodules on the scalp: Case report and published work review. ( 28714113 )
2017
48
Secondary Syphilis Associated with Membranous Nephropathy and Acute Hepatitis in a Patient with HIV: A Case Report. ( 29236656 )
2017
49
Secondary syphilis: The great imitator can't be forgotten. ( 28876421 )
2017
50
Secondary syphilis: An unusual presentation. ( 28442816 )
2017
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Variations for Secondary Syphilis

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Expression for Secondary Syphilis

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Search GEO for disease gene expression data for Secondary Syphilis.
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Pathways for Secondary Syphilis

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Pathways related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.23 CD209 CD40LG CD79A DDX41 FN1 TPR
2
Primary immunodeficiency 37
10.52 CD40LG CD79A
3
Inflammatory Response Pathway 1
10.14 CD40LG FN1
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GO Terms for Secondary Syphilis

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Cellular components related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD209 CD40LG CD79A

Biological processes related to Secondary Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.5 CD209 POLA1 TPR
2 B cell differentiation GO:0030183 9.26 CD40LG CD79A
3 positive regulation of T cell proliferation GO:0042102 9.16 CD209 CD40LG
4 B cell proliferation GO:0042100 8.96 CD40LG CD79A
5 leukocyte cell-cell adhesion GO:0007159 8.62 CD209 CD40LG
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Sources for Secondary Syphilis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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