MCID: SCR003
MIFTS: 34

Secretory Diarrhea

Categories: Gastrointestinal diseases

Aliases & Classifications for Secretory Diarrhea

MalaCards integrated aliases for Secretory Diarrhea:

Name: Secretory Diarrhea 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050129
UMLS 73 C0267557

Summaries for Secretory Diarrhea

Disease Ontology : 12 Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. The most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions.

MalaCards based summary : Secretory Diarrhea is related to diarrhea 8, secretory sodium, congenital and diarrhea 1, secretory chloride, congenital, and has symptoms including diarrhea and intermittent diarrhea. An important gene associated with Secretory Diarrhea is FOXP3 (Forkhead Box P3), and among its related pathways/superpathways are Mineral absorption and CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF). Affiliated tissues include colon, skin and small intestine, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Related Diseases for Secretory Diarrhea

Diseases related to Secretory Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 diarrhea 8, secretory sodium, congenital 33.4 SLC9A3 SPINT2
2 diarrhea 1, secretory chloride, congenital 32.3 SLC26A3 SLC9A3
3 wdha syndrome 30.0 SST VIP
4 vipoma 29.8 SST VIP
5 pancreatic cholera 29.8 SST VIP
6 cryptosporidiosis 29.8 SST VIP
7 cystic fibrosis 28.2 CFTR GUCY2C SLC9A3 VIP
8 diarrhea 28.1 FOXP3 GUCY2C MYO5B SLC26A3 SLC9A3 SPINT2
9 secretory diarrhea, myopathy, and deafness 12.1
10 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 12.0
11 diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies 11.7
12 villous adenoma 11.3
13 inflammatory diarrhea 10.6 SLC26A3 SLC9A3
14 osmotic diarrhea 10.5 SLC26A3 SLC9A3
15 diarrhea 5, with tufting enteropathy, congenital 10.3 MYO5B SPINT2
16 postgastrectomy syndrome 10.2 SST VIP
17 glucagonoma 10.2 SST VIP
18 cholera 10.1
19 somatostatinoma 10.1 SST VIP
20 binswanger's disease 10.1 SST VIP
21 duodenal atresia 10.0 CFTR GUCY2C
22 steatorrhea 10.0 CFTR SST
23 gastrinoma 10.0 SST VIP
24 megacolon 10.0 FOXP3 VIP
25 diarrhea 2, with microvillus atrophy 10.0 MYO5B SLC26A3 SLC9A3
26 islet cell tumor 10.0 SST VIP
27 congenital diarrhea 10.0 MYO5B SLC9A3 SPINT2
28 adenoma 10.0
29 graft-versus-host disease 9.9
30 crohn's disease 9.9
31 colitis 9.9
32 colonic pseudo-obstruction 9.9
33 enterocolitis 9.7
34 myopathy, congenital 9.7
35 diabetes mellitus 9.7
36 hepatitis 9.7
37 systemic mastocytosis 9.7
38 ulcerative colitis 9.7
39 collagenous colitis 9.7
40 jejunoileitis 9.7
41 protein-losing enteropathy 9.7
42 giardiasis 9.7
43 microcephaly 9.7
44 intestinal tuberculosis 9.7
45 retinal drusen 9.7
46 adenocarcinoma 9.7
47 mixed connective tissue disease 9.7
48 retinitis 9.7
49 ganglioneuroblastoma 9.7
50 myopathy 9.7

Graphical network of the top 20 diseases related to Secretory Diarrhea:



Diseases related to Secretory Diarrhea

Symptoms & Phenotypes for Secretory Diarrhea

UMLS symptoms related to Secretory Diarrhea:


diarrhea, intermittent diarrhea

MGI Mouse Phenotypes related to Secretory Diarrhea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.7 CFTR FOXP3 GUCY2C MYO5B SLC26A3 SLC9A3
2 homeostasis/metabolism MP:0005376 9.61 SLC9A3 SST VIP CFTR EMD FOXP3
3 mortality/aging MP:0010768 9.23 CFTR FOXP3 GUCY2C MYO5B SLC26A3 SPINT2

Drugs & Therapeutics for Secretory Diarrhea

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of iOWH032 in Dehydrating Cholera Withdrawn NCT02111304 Phase 2 iOWH032
2 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Recruiting NCT03261297
3 Parasitic Causes of Secretory Diarrhea in Children and Chronically Ill Adult. Not yet recruiting NCT03166670

Search NIH Clinical Center for Secretory Diarrhea

Genetic Tests for Secretory Diarrhea

Anatomical Context for Secretory Diarrhea

MalaCards organs/tissues related to Secretory Diarrhea:

41
Colon, Skin, Small Intestine, Bone, Bone Marrow

Publications for Secretory Diarrhea

Articles related to Secretory Diarrhea:

(show top 50) (show all 87)
# Title Authors Year
1
PERIPHERAL RETINAL DRUSEN-LIKE DEPOSITS IN GUCY2C CONGENITAL SECRETORY DIARRHEA SYNDROME. ( 29979251 )
2018
2
Peptide inhibitors of chloride channels for treating secretory diarrhea. ( 29772528 )
2018
3
Secretory diarrhea and hypokalemia associated with colonic pseudo-obstruction: A case study and systematic analysis of the literature. ( 28580600 )
2017
4
A case report of a giant rectal adenoma causing secretory diarrhea and acute renal failure: McKittrick-Wheelock syndrome. ( 27267899 )
2016
5
Pathogen-induced secretory diarrhea and its prevention. ( 27473379 )
2016
6
Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea. ( 26907621 )
2016
7
Gut microbial succession follows acute secretory diarrhea in humans. ( 25991682 )
2015
8
Drug-induced secretory diarrhea: A role for CFTR. ( 26429773 )
2015
9
Crofelemer: In Hiv Associated Diarrhea and Secretory Diarrhea- A Patent Perspective. ( 25851117 )
2015
10
Crofelemer for the treatment of secretory diarrhea. ( 22149578 )
2012
11
Crofelemer, a novel agent for treatment of secretory diarrhea. ( 20388859 )
2010
12
Intractable secretory diarrhea in a Japanese boy with mitochondrial respiratory chain complex I deficiency. ( 18560889 )
2009
13
Oral delivery of L-arginine stimulates prostaglandin-dependent secretory diarrhea in Cryptosporidium parvum-infected neonatal piglets. ( 18223372 )
2008
14
We may be able to stop common lethal secretory diarrhea by activating the intestinal calcium sensing receptors. ( 17435618 )
2007
15
Preventive effects of the probiotic Escherichia coli strain Nissle 1917 on acute secretory diarrhea in a pig model of intestinal infection. ( 16614995 )
2006
16
Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions. ( 16203867 )
2005
17
Stimulated active potassium secretion in a patient with colonic pseudo-obstruction: a new mechanism of secretory diarrhea. ( 16230079 )
2005
18
Legionella micdadei infection presenting as severe secretory diarrhea and a solitary pulmonary mass. ( 15034849 )
2004
19
Ataxia and secretory diarrhea: two unusual paraneoplastic syndromes occurring concurrently in the same patient with ganglioneuroblastoma. ( 15342979 )
2004
20
Secretory diarrhea owing to a tape bezoar in a child with Hirschsprung's disease. ( 14614723 )
2003
21
Congenital myopathy, recurrent secretory diarrhea, bullous eruption of skin, microcephaly, and deafness: a new genetic syndrome? ( 12476446 )
2003
22
Alternative treatment for secretory diarrhea revealed in a new class of CFTR inhibitors. ( 12464662 )
2002
23
Acute appendicitis presenting as secretory diarrhea. ( 12037768 )
2002
24
Role of the enteric nervous system in the pathophysiology of secretory diarrhea. ( 12041649 )
2002
25
Effects of an alanyl-glutamine-based oral rehydration and nutrition therapy solution on electrolyte and water absorption in a rat model of secretory diarrhea induced by cholera toxin. ( 12044816 )
2002
26
Continuous octreotide infusion for the treatment of secretory diarrhea caused by acute intestinal graft-versus-host disease in a child. ( 10959906 )
2000
27
New insights into the pathogenesis of intestinal dysfunction: secretory diarrhea and cystic fibrosis. ( 11830825 )
2000
28
Secretory diarrhea. ( 10980977 )
1999
29
Adenocarcinoma of the colon with neuroendocrine features and secretory diarrhea. ( 10364049 )
1999
30
Lansoprazole: a cause of secretory diarrhea. ( 9820425 )
1998
31
Efficacy of a glutamine-based oral rehydration solution on the electrolyte and water absorption in a rabbit model of secretory diarrhea induced by cholera toxin. ( 9586761 )
1998
32
Effects of KW-5617 (zaldaride maleate), a potent and selective calmodulin inhibitor, on secretory diarrhea and on gastrointestinal propulsion in rats. ( 9541283 )
1998
33
Effect of fludrocortisone and spironolactone on sodium and potassium losses in secretory diarrhea. ( 9009126 )
1997
34
Secretory diarrhea caused by ipecac poisoning. ( 9161961 )
1997
35
Massive secretory diarrhea and pseudo-obstruction as the initial presentation of Crohn's disease. ( 8835903 )
1996
36
Secretory diarrhea in children: newly recognized toxins and hormone-secreting tumors. ( 8614604 )
1996
37
A pharmacological approach to secretory diarrhea. ( 7743122 )
1995
38
Hexamethonium and secretory diarrhea. ( 7797038 )
1995
39
Consensus statement: octreotide dose titration in secretory diarrhea. Diarrhea Management Consensus Development Panel. ( 7628270 )
1995
40
Reactive oxygen and nitrogen metabolites as mediators of secretory diarrhea. ( 7498670 )
1995
41
Human intestinal cryptosporidiosis: secretory diarrhea and enterotoxic activity in Caco-2 cells. ( 7706827 )
1995
42
Effect of psyllium, calcium polycarbophil, and wheat bran on secretory diarrhea induced by phenolphthalein. ( 8385040 )
1993
43
Bicarbonate and citrate in oral rehydration therapy: studies in a model of secretory diarrhea. ( 8492256 )
1993
44
Control study of oral rehydration solution (ORS)/ORS + dioctahedral smectite in hospitalized Thai infants with acute secretory diarrhea. ( 1488694 )
1992
45
Sigmoid volvulus presenting as chronic secretory diarrhea responsive to octreotide. ( 1728114 )
1992
46
Secretory diarrhea in villous adenoma of rectum: effect of treatment with somatostatin and indomethacin. ( 1410521 )
1992
47
The effect of nifedipine on secretory diarrhea in mice. ( 1440948 )
1992
48
Secretory diarrhea and candidal overgrowth: cause and effect? ( 1894948 )
1991
49
Congenital diabetes mellitus and fatal secretory diarrhea in two infants. ( 1779317 )
1991
50
Secretory diarrhea following a dog bite. ( 1864208 )
1991

Variations for Secretory Diarrhea

Expression for Secretory Diarrhea

Search GEO for disease gene expression data for Secretory Diarrhea.

Pathways for Secretory Diarrhea

Pathways related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.66 SLC26A3 SLC9A3
2 10.17 CFTR SPINT2

GO Terms for Secretory Diarrhea

Cellular components related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.13 CFTR SLC26A3 SLC9A3
2 brush border membrane GO:0031526 8.62 SLC26A3 SLC9A3

Biological processes related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to cAMP GO:0071320 9.4 CFTR SLC26A3
2 bicarbonate transport GO:0015701 9.37 CFTR SLC26A3
3 regulation of intracellular pH GO:0051453 9.32 SLC26A3 SLC9A3
4 digestion GO:0007586 9.26 GUCY2C SST
5 sperm capacitation GO:0048240 9.16 CFTR SLC26A3
6 membrane hyperpolarization GO:0060081 8.96 CFTR SLC26A3
7 intracellular pH elevation GO:0051454 8.62 CFTR SLC26A3

Molecular functions related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antiporter activity GO:0015297 9.16 SLC26A3 SLC9A3
2 bicarbonate transmembrane transporter activity GO:0015106 8.96 CFTR SLC26A3
3 chloride transmembrane transporter activity GO:0015108 8.62 CFTR SLC26A3

Sources for Secretory Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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