MCID: SCR003
MIFTS: 35

Secretory Diarrhea

Categories: Gastrointestinal diseases

Aliases & Classifications for Secretory Diarrhea

MalaCards integrated aliases for Secretory Diarrhea:

Name: Secretory Diarrhea 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0050129
UMLS 70 C0267557

Summaries for Secretory Diarrhea

Disease Ontology : 12 Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. The most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions.

MalaCards based summary : Secretory Diarrhea is related to diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies and diarrhea 8, secretory sodium, congenital, and has symptoms including diarrhea and intermittent diarrhea. An important gene associated with Secretory Diarrhea is SLC9A3 (Solute Carrier Family 9 Member A3), and among its related pathways/superpathways are Salivary secretion and G12-G13 in Cellular Signaling. Affiliated tissues include colon, neutrophil and kidney, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Secretory Diarrhea

Diseases related to Secretory Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies 32.5 SPINT2 SLC9A3 GUCY2C
2 diarrhea 8, secretory sodium, congenital 32.5 SLC9A3 MYO5B CFTR
3 diarrhea 1, secretory chloride, congenital 31.9 SLC9A3 SLC9A2 SLC26A3
4 diarrhea 30.9 SST SPINT2 SLC9A3 SLC9A2 SLC26A3 PLVAP
5 dysentery 30.4 SLC9A3 SLC26A3 PRSS57
6 acute diarrhea 30.2 SLC9A3R2 SLC9A3 PRSS57
7 short bowel syndrome 30.2 SST SLC9A3 SLC9A2
8 pancreatic cholera 30.1 VIP SST
9 volvulus of midgut 29.9 SST GUCY2C
10 megacolon 29.8 VIP FOXP3 CFTR
11 gastrinoma 29.8 VIP SST GRP
12 intestinal pseudo-obstruction 29.8 VIP SST CFTR
13 neuroendocrine tumor 29.6 VIP SST GRP
14 osmotic diarrhea 29.5 SLC9A3 SLC9A2 SLC26A3 PRSS57 GUCA2A
15 constipation 29.5 VIP SST NPR3 GUCY2C GUCA2A GRP
16 cystic fibrosis 28.7 VIP SLC9A3R2 SLC9A3 PRKG2 GUCY2C GUCA2A
17 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 11.8
18 secretory diarrhea, myopathy, and deafness 11.3
19 diarrhea 10, protein-losing enteropathy type 11.2
20 cholera 10.5
21 intestinal impaction 10.3 SLC9A3 SLC26A3
22 hypokalemia 10.3
23 spermatocele 10.3 SLC9A3 SLC26A3 CFTR
24 large intestine adenoma 10.2 GUCY2C GUCA2A
25 biliary dyskinesia 10.2 SST CFTR
26 bile acid malabsorption, primary 10.2 SST CFTR
27 meconium ileus 10.2 SLC9A3 GUCY2C CFTR
28 intestinal obstruction 10.2 SLC26A3 GUCY2C CFTR
29 villous adenoma 10.1
30 adenoma 10.1
31 rectum neuroendocrine neoplasm 10.1 VIP SST
32 endocrine pancreas disease 10.1 VIP SST
33 glucagonoma 10.1 VIP SST
34 acrokeratoderma, hereditary papulotranslucent 10.1 VIP CFTR
35 colon neuroendocrine neoplasm 10.1 VIP SST
36 inflammatory diarrhea 10.1 SLC9A3R2 SLC9A3 SLC9A2 SLC26A3
37 congenital diarrhea 10.1 SPINT2 SLC9A3 SLC26A3 MYO5B
38 metabolic acidosis 10.1
39 colitis 10.1
40 binswanger's disease 10.1 VIP SST
41 diarrhea 2, with microvillus atrophy 10.1 SLC9A3 SLC26A3 PLVAP MYO5B
42 bartter disease 10.1 SLC9A3 SLC9A2 SLC26A3 CFTR
43 graves disease 1 10.0
44 graft-versus-host disease 10.0
45 collagenous colitis 10.0
46 protein-losing enteropathy 10.0
47 colonic pseudo-obstruction 10.0
48 crohn's disease 10.0
49 irritable bowel syndrome 10.0
50 hypoglycemia 10.0

Graphical network of the top 20 diseases related to Secretory Diarrhea:



Diseases related to Secretory Diarrhea

Symptoms & Phenotypes for Secretory Diarrhea

UMLS symptoms related to Secretory Diarrhea:


diarrhea; intermittent diarrhea

MGI Mouse Phenotypes related to Secretory Diarrhea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.03 CFTR FOXP3 GUCA2A GUCY2C MYO5B PLVAP
2 endocrine/exocrine gland MP:0005379 9.85 CFTR FOXP3 GUCA2A NPR3 PLVAP SLC26A3
3 homeostasis/metabolism MP:0005376 9.83 CFTR EMD FOXP3 GRP GUCY2C MYO5B
4 immune system MP:0005387 9.36 CFTR FOXP3 GUCA2A GUCY2C LPAR2 NPR3

Drugs & Therapeutics for Secretory Diarrhea

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Two-Part Trial to Evaluate the Efficacy, Safety, and Tolerability of iOWH032 in the Treatment of Acute Dehydrating Diarrhea in Adult and Pediatric Patients With Cholera Withdrawn NCT02111304 Phase 2 iOWH032
2 Parasitic Causes of Secretory Diarrhea in Children and Chronically Ill Adult. Not yet recruiting NCT03166670

Search NIH Clinical Center for Secretory Diarrhea

Genetic Tests for Secretory Diarrhea

Anatomical Context for Secretory Diarrhea

MalaCards organs/tissues related to Secretory Diarrhea:

40
Colon, Neutrophil, Kidney, Bone Marrow, Small Intestine, Pancreas, Breast

Publications for Secretory Diarrhea

Articles related to Secretory Diarrhea:

(show top 50) (show all 567)
# Title Authors PMID Year
1
Tannins extract from Galla Chinensis can protect mice from infection by Enterotoxigenic Escherichia coli O101. 61
33676495 2021
2
Repurposing calcium-sensing receptor agonist cinacalcet for treatment of CFTR-mediated secretory diarrheas. 61
33400691 2021
3
Correspondence: Microvillus Inclusion Disease with Novel MYO5B Pathogenic Variants. 61
33544913 2021
4
Dysregulation of intestinal epithelial CFTR-dependent Cl- ion transport and paracellular barrier function drives gastrointestinal symptoms of food-induced anaphylaxis in mice. 61
32576925 2021
5
PERIPHERAL RETINAL DRUSEN-LIKE DEPOSITS IN GUCY2C CONGENITAL SECRETORY DIARRHEA SYNDROME. 61
29979251 2021
6
KCNN4 Expression Is Elevated in Inflammatory Bowel Disease: This Might Be a Novel Marker and Therapeutic Option Targeting Potassium Channels. 61
33331347 2020
7
Pharmacological and Parenteral Nutrition-Based Interventions in Microvillus Inclusion Disease. 61
33374831 2020
8
Impact of the Escherichia coli Heat-Stable Enterotoxin b (STb) on Gut Health and Function. 61
33276476 2020
9
Isolation of CFTR and TMEM16A inhibitors from Neorautanenia mitis (A. Rich) Verdcourt: Potential lead compounds for treatment of secretory diarrhea. 61
32798746 2020
10
Lysophosphatidic Acid Increases Maturation of Brush Borders and SGLT1 Activity in MYO5B-deficient Mice, a Model of Microvillus Inclusion Disease. 61
32534933 2020
11
Inhibition of CFTR-mediated intestinal chloride secretion by a fungus-derived arthropsolide A: Mechanism of action and anti-diarrheal efficacy. 61
32712094 2020
12
Comprehensive Targeted Sequencing Identifies Monogenic Disorders in Patients With Early-onset Refractory Diarrhea. 61
32487952 2020
13
Potential for dehydration to impact the athlete biological passport. 61
32311833 2020
14
New Insights Into the Indications for Intestinal Transplantation: Consensus in the Year 2019. 61
31815899 2020
15
Chronic Diarrhea in Adults: Evaluation and Differential Diagnosis. 61
32293842 2020
16
A Rare Cause of Refractory Chronic Diarrhea and Cachexia: A Case Report. 61
32461947 2020
17
Neuroendocrine pancreatic tumor causing chronic diarrhea in young adult, a case report. 61
32420536 2020
18
Glucocorticoids and myosin5b loss of function induce heightened PKA signaling in addition to membrane traffic defects. 61
31664880 2019
19
Vibrio cholerae at the Intersection of Immunity and the Microbiome. 61
31776240 2019
20
An Ancient CFTR Ortholog Informs Molecular Evolution in ABC Transporters. 61
31679858 2019
21
Diarrhea: a missed D in the 4D glucagonoma syndrome. 61
31807436 2019
22
Adenylyl Cyclase 6 Expression Is Essential for Cholera Toxin-Induced Diarrhea. 61
30624615 2019
23
Microvillous Inclusion Disease as a Cause of Protracted Diarrhea. 61
31049800 2019
24
Discovery of a novel chalcone derivative inhibiting CFTR chloride channel via AMPK activation and its anti-diarrheal application. 61
31444000 2019
25
Microgels Sopping Up Toxins-GM1a-Functionalized Microgels as Scavengers for Cholera Toxin. 61
31265226 2019
26
Pancreatic neuroendocrine microadenomatosis presenting as a functional VIPoma. 61
31275551 2019
27
Application of Whole Exome Sequencing in Congenital Secretory Diarrhea Diagnosis. 61
30633106 2019
28
Capsaicin inhibitory effects on Vibrio cholerae toxin genes expression. 61
31143687 2019
29
Synthesis and Pharmacological Screening of Pyridopyrimidines as Effective Anti-Diarrheal Agents through the Suppression of Cyclic Nucleotide Accumulation. 61
31008011 2019
30
Lysophosphatidic acid type 2 receptor agonists in targeted drug development offer broad therapeutic potential. 61
30692142 2019
31
Case Report on a Rare Disease in Lithuania: Congenital Chloride Diarrhea. 61
30775050 2019
32
A Rare Case of Acute Kidney Injury: McKittrick Wheelock Syndrome. 61
30988251 2019
33
Antidiarrheal activity of α-terpineol in mice. 61
30540974 2019
34
Synthesis of phenylpyrimidinones as guanylyl cyclase C inhibitors. 61
30782244 2019
35
Chronic Diarrhea Secondary to Newly Diagnosed VIPoma. 61
31123451 2019
36
Plumbagin Prevents Secretory Diarrhea by Inhibiting CaCC and CFTR Channel Activities. 61
31649543 2019
37
Modifications of cholera toxin subunit B binding to human large intestinal epithelium. An immunohistochemical study. 61
30145256 2018
38
Visualization-assisted binning of metagenome assemblies reveals potential new pathogenic profiles in idiopathic travelers' diarrhea. 61
30409177 2018
39
Antidiarrheal activity of a novel sulfated polysaccharide from the red seaweed Gracilaria cervicornis. 61
29803569 2018
40
Prevention and treatment of secretory diarrhea by the lysophosphatidic acid analog Rx100. 61
30253666 2018
41
Barrett's esophagus in children: what is the evidence? 61
29992379 2018
42
AC6 is the major adenylate cyclase forming a diarrheagenic protein complex with cystic fibrosis transmembrane conductance regulator in cholera. 61
29903911 2018
43
Slc26a3 deficiency is associated with epididymis dysplasia and impaired sperm fertilization potential in the mouse. 61
30118583 2018
44
Peptide inhibitors of chloride channels for treating secretory diarrhea. 61
29772528 2018
45
Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. 61
29653944 2018
46
Application of the biotin-labeled toxin mutant for affinity isolation of associated proteins in the mammalian cells. 61
29291913 2018
47
Congenital sodium diarrhea and chorioretinal coloboma with optic disc coloboma in a patient with biallelic SPINT2 mutations, including p.(Tyr163Cys). 61
29575628 2018
48
Resveratrol dimer trans-ε-viniferin prevents rotaviral diarrhea in mice by inhibition of the intestinal calcium-activated chloride channel. 61
29155014 2018
49
McKittrick Wheelock Syndrome Treated by Transanal Minimally Invasive Surgery: A Single-Center Experience and Review of the Literature. 61
28657837 2018
50
Apical Membrane Alterations in Non-intestinal Organs in Microvillus Inclusion Disease. 61
29218485 2018

Variations for Secretory Diarrhea

Expression for Secretory Diarrhea

Search GEO for disease gene expression data for Secretory Diarrhea.

Pathways for Secretory Diarrhea

Pathways related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.06 SST SLC26A3 PRKG2 CFTR
2 11.63 SLC9A3 SLC9A2 LPAR2
3
Show member pathways
11.24 SLC9A3R2 PRKG2 MYO5B LPAR2 CFTR
4 10.37 PRKG2 CFTR
5 10 VIP GRP
6 9.56 GUCY2C GUCA2A

GO Terms for Secretory Diarrhea

Cellular components related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.02 SLC9A3R2 SLC9A3 SLC26A3 PRKG2 CFTR

Biological processes related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sperm capacitation GO:0048240 9.4 SLC26A3 CFTR
2 sodium ion import across plasma membrane GO:0098719 9.37 SLC9A3 SLC9A2
3 anion transmembrane transport GO:0098656 9.33 SLC9A3 SLC9A2 SLC26A3
4 regulation of pH GO:0006885 9.32 SLC9A3 SLC9A2
5 membrane hyperpolarization GO:0060081 9.26 SLC26A3 CFTR
6 intracellular pH elevation GO:0051454 8.96 SLC26A3 CFTR
7 digestion GO:0007586 8.8 SST GUCY2C GUCA2A

Molecular functions related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.61 VIP SST GUCA2A
2 solute:proton antiporter activity GO:0015299 9.4 SLC9A3 SLC9A2
3 chloride transmembrane transporter activity GO:0015108 9.37 SLC26A3 CFTR
4 bicarbonate transmembrane transporter activity GO:0015106 9.32 SLC26A3 CFTR
5 sodium:proton antiporter activity GO:0015385 9.26 SLC9A3 SLC9A2
6 potassium:proton antiporter activity GO:0015386 9.16 SLC9A3 SLC9A2
7 antiporter activity GO:0015297 9.13 SLC9A3 SLC9A2 SLC26A3
8 natriuretic peptide receptor activity GO:0016941 8.62 NPR3 GUCY2C

Sources for Secretory Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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