MCID: SCR003
MIFTS: 37

Secretory Diarrhea

Categories: Gastrointestinal diseases

Aliases & Classifications for Secretory Diarrhea

MalaCards integrated aliases for Secretory Diarrhea:

Name: Secretory Diarrhea 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050129
UMLS 71 C0267557

Summaries for Secretory Diarrhea

Disease Ontology : 12 Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. The most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions.

MalaCards based summary : Secretory Diarrhea is related to diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies and diarrhea 8, secretory sodium, congenital, and has symptoms including diarrhea and intermittent diarrhea. An important gene associated with Secretory Diarrhea is FOXP3 (Forkhead Box P3), and among its related pathways/superpathways are G12-G13 in Cellular Signaling and Regulation of CFTR activity (norm and CF). The drugs Theophylline and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and kidney, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Related Diseases for Secretory Diarrhea

Diseases related to Secretory Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies 33.8 SPINT2 SLC9A3 GUCY2C
2 diarrhea 8, secretory sodium, congenital 33.7 SLC9A3 MYO5B CFTR
3 diarrhea 1, secretory chloride, congenital 32.3 SLC9A3 SLC9A2 SLC26A3
4 diarrhea 30.9 SST SPINT2 SLC9A3R2 SLC9A3 SLC9A2 SLC26A3
5 pancreatic cholera 30.4 VIP SST
6 acute diarrhea 30.3 SLC9A3R2 SLC9A3 PRSS57
7 short bowel syndrome 30.1 VIP SST SLC9A3
8 gastrinoma 29.8 VIP SST GRP
9 neuroendocrine tumor 29.5 VIP SST GRP
10 osmotic diarrhea 29.4 SLC9A3 SLC9A2 SLC26A3 PRSS57 GUCA2A
11 constipation 29.3 VIP SST NPR3 GUCY2C GUCA2A GRP
12 cystic fibrosis 28.7 VIP SLC9A3R2 SLC9A3 PRKG2 GUCY2C GUCA2A
13 secretory diarrhea, myopathy, and deafness 12.6
14 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 12.5
15 diarrhea 10, protein-losing enteropathy type 11.4
16 cholera 10.5
17 intestinal impaction 10.4 SLC9A3 SLC26A3
18 large intestine adenoma 10.3 GUCY2C GUCA2A
19 bile acid malabsorption, primary 10.3 SST CFTR
20 motility-related diarrhea 10.3 SLC9A2 GUCA2A
21 biliary dyskinesia 10.3 SST CFTR
22 hypokalemia 10.3
23 meconium ileus 10.2 SLC9A3 GUCY2C CFTR
24 rectum neuroendocrine neoplasm 10.2 VIP SST
25 pancreatic somatostatinoma 10.2 VIP SST
26 adenoma 10.2
27 intestinal obstruction 10.2 SST GUCY2C CFTR
28 glucagonoma 10.2 VIP SST
29 diarrhea 4, malabsorptive, congenital 10.2 SPINT2 MYO5B
30 endocrine pancreas disease 10.2 VIP SST
31 acrokeratoderma, hereditary papulotranslucent 10.1 VIP CFTR
32 binswanger's disease 10.1 VIP SST
33 villous adenoma 10.1
34 dysentery 10.1
35 congenital diarrhea 10.1 SPINT2 SLC9A3 SLC26A3 MYO5B
36 diarrhea 2, with microvillus atrophy 10.1 SLC9A3 SLC26A3 PLVAP MYO5B
37 inflammatory diarrhea 10.1 SLC9A3R2 SLC9A3 SLC9A2 SLC26A3
38 metabolic acidosis 10.1
39 colitis 10.1
40 diarrhea 5, with tufting enteropathy, congenital 10.0 SPINT2 SLC9A3 SLC26A3 PLVAP MYO5B
41 graves disease 1 10.0
42 graft-versus-host disease 10.0
43 collagenous colitis 10.0
44 protein-losing enteropathy 10.0
45 colonic pseudo-obstruction 10.0
46 crohn's disease 10.0
47 irritable bowel syndrome 10.0
48 hypoglycemia 10.0
49 autonomic nervous system benign neoplasm 10.0 VIP SST
50 anismus 9.9 VIP NPR3 GUCA2A

Graphical network of the top 20 diseases related to Secretory Diarrhea:



Diseases related to Secretory Diarrhea

Symptoms & Phenotypes for Secretory Diarrhea

UMLS symptoms related to Secretory Diarrhea:


diarrhea, intermittent diarrhea

MGI Mouse Phenotypes related to Secretory Diarrhea:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.7 CFTR FOXP3 GUCA2A GUCY2C MYO5B PLVAP
2 homeostasis/metabolism MP:0005376 9.47 CFTR EMD FOXP3 GUCY2C MYO5B NPR3

Drugs & Therapeutics for Secretory Diarrhea

Drugs for Secretory Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Theophylline Approved Phase 1 58-55-9 2153
2
tannic acid Approved Phase 1 1401-55-4
3
Benzocaine Approved, Investigational Phase 1 94-09-7, 1994-09-7 2337
4
Erlotinib Hydrochloride Phase 1 183319-69-9 176871
5 Respiratory System Agents Phase 1
6 Protein Kinase Inhibitors Phase 1
7 Phosphodiesterase Inhibitors Phase 1
8 Anti-Asthmatic Agents Phase 1
9 Vasodilator Agents Phase 1
10 Bronchodilator Agents Phase 1
11 Neurotransmitter Agents Phase 1
12
Sucralfate Approved 54182-58-0
13 Antacids
14 Anti-Ulcer Agents
15 Gastrointestinal Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Two-Part Trial to Evaluate the Efficacy, Safety, and Tolerability of iOWH032 in the Treatment of Acute Dehydrating Diarrhea in Adult and Pediatric Patients With Cholera Withdrawn NCT02111304 Phase 2 iOWH032
2 A Phase I, Single-center, Non-randomized, Open-label Study to Determine the Lowest Effective Theophylline Dose That Decreased Erlotinib's Diarrhea at the Standard Dose of 150 mg/Day and to Determine the Highest Erlotinib Dose in Combination With Theophylline That Can be Administered to Patients Terminated NCT02080078 Phase 1 Theophylline;Erlotinib
3 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Unknown status NCT03261297
4 Treatment and Prevention of Oral and Alimentary Mucositis Using Polymerized Cross-Linked High Potency Sucralfate as a Single Agent Therapy Unknown status NCT02016807
5 Protective Immunity to Human Cholera in Bangladesh-EGD Substudy Completed NCT00349999
6 Parasitic Causes of Secretory Diarrhea in Children and Chronically Ill Adult. Not yet recruiting NCT03166670

Search NIH Clinical Center for Secretory Diarrhea

Genetic Tests for Secretory Diarrhea

Anatomical Context for Secretory Diarrhea

MalaCards organs/tissues related to Secretory Diarrhea:

40
Colon, Small Intestine, Kidney, Liver, Bone Marrow, Bone, Heart

Publications for Secretory Diarrhea

Articles related to Secretory Diarrhea:

(show top 50) (show all 559)
# Title Authors PMID Year
1
Comprehensive Targeted Sequencing Identifies Monogenic Disorders in Patients With Early-onset Refractory Diarrhea. 61
32487952 2020
2
Lysophosphatidic Acid Increases Maturation of Brush Borders and SGLT1 activity in MYO5B-deficient Mice, a Model of Microvillus Inclusion Disease. 61
32534933 2020
3
Dysregulation of intestinal epithelial CFTR-dependent Cl- ion transport and paracellular barrier function drives gastrointestinal symptoms of food-induced anaphylaxis in mice. 61
32576925 2020
4
New Insights Into the Indications for Intestinal Transplantation: Consensus in the Year 2019. 61
31815899 2020
5
Potential for dehydration to impact the athlete biological passport. 61
32311833 2020
6
Chronic Diarrhea in Adults: Evaluation and Differential Diagnosis. 61
32293842 2020
7
A Rare Cause of Refractory Chronic Diarrhea and Cachexia: A Case Report. 61
32461947 2020
8
Neuroendocrine pancreatic tumor causing chronic diarrhea in young adult, a case report. 61
32420536 2020
9
Glucocorticoids and myosin5b loss of function induce heightened PKA signaling in addition to membrane traffic defects. 61
31664880 2019
10
An Ancient CFTR Ortholog Informs Molecular Evolution in ABC Transporters. 61
31679858 2019
11
Vibrio cholerae at the Intersection of Immunity and the Microbiome. 61
31776240 2019
12
Adenylyl Cyclase 6 Expression Is Essential for Cholera Toxin-Induced Diarrhea. 61
30624615 2019
13
Diarrhea: a missed D in the 4D glucagonoma syndrome. 61
31807436 2019
14
Microvillous Inclusion Disease as a Cause of Protracted Diarrhea. 61
31049800 2019
15
Microgels Sopping Up Toxins-GM1a-Functionalized Microgels as Scavengers for Cholera Toxin. 61
31265226 2019
16
Discovery of a novel chalcone derivative inhibiting CFTR chloride channel via AMPK activation and its anti-diarrheal application. 61
31444000 2019
17
Pancreatic neuroendocrine microadenomatosis presenting as a functional VIPoma. 61
31275551 2019
18
Application of Whole Exome Sequencing in Congenital Secretory Diarrhea Diagnosis. 61
30633106 2019
19
Capsaicin inhibitory effects on Vibrio cholerae toxin genes expression. 61
31143687 2019
20
Synthesis and Pharmacological Screening of Pyridopyrimidines as Effective Anti-Diarrheal Agents through the Suppression of Cyclic Nucleotide Accumulation. 61
31008011 2019
21
Lysophosphatidic acid type 2 receptor agonists in targeted drug development offer broad therapeutic potential. 61
30692142 2019
22
Case Report on a Rare Disease in Lithuania: Congenital Chloride Diarrhea. 61
30775050 2019
23
A Rare Case of Acute Kidney Injury: McKittrick Wheelock Syndrome. 61
30988251 2019
24
Antidiarrheal activity of α-terpineol in mice. 61
30540974 2019
25
Chronic Diarrhea Secondary to Newly Diagnosed VIPoma. 61
31123451 2019
26
Synthesis of phenylpyrimidinones as guanylyl cyclase C inhibitors. 61
30782244 2019
27
Plumbagin Prevents Secretory Diarrhea by Inhibiting CaCC and CFTR Channel Activities. 61
31649543 2019
28
Modifications of cholera toxin subunit B binding to human large intestinal epithelium. An immunohistochemical study. 61
30145256 2018
29
Visualization-assisted binning of metagenome assemblies reveals potential new pathogenic profiles in idiopathic travelers' diarrhea. 61
30409177 2018
30
Antidiarrheal activity of a novel sulfated polysaccharide from the red seaweed Gracilaria cervicornis. 61
29803569 2018
31
Prevention and treatment of secretory diarrhea by the lysophosphatidic acid analog Rx100. 61
30253666 2018
32
AC6 is the major adenylate cyclase forming a diarrheagenic protein complex with cystic fibrosis transmembrane conductance regulator in cholera. 61
29903911 2018
33
Barrett's esophagus in children: what is the evidence? 61
29992379 2018
34
Slc26a3 deficiency is associated with epididymis dysplasia and impaired sperm fertilization potential in the mouse. 61
30118583 2018
35
PERIPHERAL RETINAL DRUSEN-LIKE DEPOSITS IN GUCY2C CONGENITAL SECRETORY DIARRHEA SYNDROME. 61
29979251 2018
36
Peptide inhibitors of chloride channels for treating secretory diarrhea. 61
29772528 2018
37
Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. 61
29653944 2018
38
Application of the biotin-labeled toxin mutant for affinity isolation of associated proteins in the mammalian cells. 61
29291913 2018
39
Congenital sodium diarrhea and chorioretinal coloboma with optic disc coloboma in a patient with biallelic SPINT2 mutations, including p.(Tyr163Cys). 61
29575628 2018
40
Resveratrol dimer trans-ε-viniferin prevents rotaviral diarrhea in mice by inhibition of the intestinal calcium-activated chloride channel. 61
29155014 2018
41
Apical Membrane Alterations in Non-intestinal Organs in Microvillus Inclusion Disease. 61
29218485 2018
42
McKittrick Wheelock Syndrome Treated by Transanal Minimally Invasive Surgery: A Single-Center Experience and Review of the Literature. 61
28657837 2018
43
Affinity capillary electrophoresis for the assessment of binding affinity of carbohydrate-based cholera toxin inhibitors. 61
28905402 2018
44
Zinc strengthens the jejunal barrier by reversibly tightening the paracellular route. 61
28864501 2017
45
Enterotoxigenic Escherichia coli targeting intestinal epithelial tight junctions: An effective way to alter the barrier integrity. 61
29079214 2017
46
Secretory diarrhea and hypokalemia associated with colonic pseudo-obstruction: A case study and systematic analysis of the literature. 61
28580600 2017
47
The Botanical Drug Substance Crofelemer as a Model System for Comparative Characterization of Complex Mixture Drugs. 61
28743606 2017
48
ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice. 61
28895923 2017
49
Roflumilast reverses CFTR-mediated ion transport dysfunction in cigarette smoke-exposed mice. 61
28923049 2017
50
CFTR-NHERF2-LPA₂ Complex in the Airway and Gut Epithelia. 61
28869532 2017

Variations for Secretory Diarrhea

Expression for Secretory Diarrhea

Search GEO for disease gene expression data for Secretory Diarrhea.

Pathways for Secretory Diarrhea

Pathways related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.59 SLC9A3 SLC9A2 LPAR2
2
Show member pathways
11.24 SLC9A3R2 PRKG2 MYO5B LPAR2 CFTR
3 10.37 PRKG2 CFTR
4 10 VIP GRP
5 9.56 GUCY2C GUCA2A

GO Terms for Secretory Diarrhea

Cellular components related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.5 SLC9A3 SLC9A2 SLC26A3 MYO5B LPAR2 CFTR
2 apical plasma membrane GO:0016324 9.02 SLC9A3R2 SLC9A3 SLC26A3 PRKG2 CFTR

Biological processes related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sperm capacitation GO:0048240 9.4 SLC26A3 CFTR
2 regulation of pH GO:0006885 9.37 SLC9A3 SLC9A2
3 anion transmembrane transport GO:0098656 9.33 SLC9A3 SLC9A2 SLC26A3
4 sodium ion import across plasma membrane GO:0098719 9.32 SLC9A3 SLC9A2
5 membrane hyperpolarization GO:0060081 9.26 SLC26A3 CFTR
6 intracellular pH elevation GO:0051454 8.96 SLC26A3 CFTR
7 digestion GO:0007586 8.8 SST GUCY2C GUCA2A

Molecular functions related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.61 VIP SST GUCA2A
2 solute:proton antiporter activity GO:0015299 9.4 SLC9A3 SLC9A2
3 chloride transmembrane transporter activity GO:0015108 9.37 SLC26A3 CFTR
4 bicarbonate transmembrane transporter activity GO:0015106 9.32 SLC26A3 CFTR
5 sodium:proton antiporter activity GO:0015385 9.26 SLC9A3 SLC9A2
6 potassium:proton antiporter activity GO:0015386 9.16 SLC9A3 SLC9A2
7 antiporter activity GO:0015297 9.13 SLC9A3 SLC9A2 SLC26A3
8 natriuretic peptide receptor activity GO:0016941 8.62 NPR3 GUCY2C

Sources for Secretory Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....