MCID: SCR003
MIFTS: 36

Secretory Diarrhea

Categories: Gastrointestinal diseases

Aliases & Classifications for Secretory Diarrhea

MalaCards integrated aliases for Secretory Diarrhea:

Name: Secretory Diarrhea 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0050129
UMLS 72 C0267557

Summaries for Secretory Diarrhea

Disease Ontology : 12 Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. The most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions.

MalaCards based summary : Secretory Diarrhea is related to diarrhea 8, secretory sodium, congenital and diarrhea, and has symptoms including diarrhea and intermittent diarrhea. An important gene associated with Secretory Diarrhea is FOXP3 (Forkhead Box P3), and among its related pathways/superpathways are Bile secretion and Mineral absorption. The drugs tannic acid and Theophylline have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Related Diseases for Secretory Diarrhea

Diseases related to Secretory Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 diarrhea 8, secretory sodium, congenital 33.8 SPINT2 SLC9A3
2 diarrhea 29.0 SST SPINT2 SLC9A3 SLC26A3 MYO5B GUCY2C
3 cystic fibrosis 28.6 SLC9A3 GUCY2C CFTR
4 secretory diarrhea, myopathy, and deafness 12.6
5 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 12.5
6 diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies 12.2
7 villous adenoma 11.6
8 diarrhea 10, protein-losing enteropathy type 11.4
9 cholera 10.5
10 diarrhea 1, secretory chloride, congenital 10.3 SLC9A3 SLC26A3
11 hypokalemia 10.3
12 adenoma 10.2
13 dysentery 10.1
14 constipation 10.1
15 diarrhea 5, with tufting enteropathy, congenital 10.1 SPINT2 MYO5B
16 acute diarrhea 10.1
17 metabolic acidosis 10.1
18 colitis 10.1
19 pancreatic cholera 10.1
20 autoimmune pancreatitis 10.0 FOXP3 CFTR
21 graves disease 1 10.0
22 graft-versus-host disease 10.0
23 collagenous colitis 10.0
24 short bowel syndrome 10.0
25 protein-losing enteropathy 10.0
26 colonic pseudo-obstruction 10.0
27 crohn's disease 10.0
28 irritable bowel syndrome 10.0
29 hypoglycemia 10.0
30 wdha syndrome 10.0
31 steatorrhea 9.9 SST CFTR
32 diarrhea 2, with microvillus atrophy 9.9 SLC9A3 SLC26A3 MYO5B
33 congenital diarrhea 9.9 SPINT2 SLC9A3 MYO5B
34 diarrhea, glucose-stimulated secretory, with common variable immunodeficiency 9.8
35 exudative vitreoretinopathy 1 9.8
36 fibrosis of extraocular muscles, congenital, 1 9.8
37 sorsby fundus dystrophy 9.8
38 neuropathy, hereditary sensory and autonomic, type iii 9.8
39 enterocolitis 9.8
40 immune deficiency disease 9.8
41 myopathy, congenital 9.8
42 neuroblastoma 1 9.8
43 ataxia and polyneuropathy, adult-onset 9.8
44 congenital disorder of glycosylation, type ib 9.8
45 branchiootic syndrome 1 9.8
46 ovarian hyperstimulation syndrome 9.8
47 osmotic diarrhea 9.8
48 exanthem 9.8
49 zollinger-ellison syndrome 9.8
50 biotin deficiency 9.8

Graphical network of the top 20 diseases related to Secretory Diarrhea:



Diseases related to Secretory Diarrhea

Symptoms & Phenotypes for Secretory Diarrhea

UMLS symptoms related to Secretory Diarrhea:


diarrhea, intermittent diarrhea

MGI Mouse Phenotypes related to Secretory Diarrhea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.76 CFTR FOXP3 GUCY2C MYO5B PLVAP SLC26A3
2 homeostasis/metabolism MP:0005376 9.61 CFTR EMD FOXP3 GUCY2C MYO5B PLVAP
3 mortality/aging MP:0010768 9.23 CFTR FOXP3 GUCY2C MYO5B PLVAP SLC26A3

Drugs & Therapeutics for Secretory Diarrhea

Drugs for Secretory Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved Phase 1 1401-55-4
2
Theophylline Approved Phase 1 58-55-9 2153
3
Benzocaine Approved, Investigational Phase 1 94-09-7, 1994-09-7 2337
4 Neurotransmitter Agents Phase 1
5 Purinergic P1 Receptor Antagonists Phase 1
6 Respiratory System Agents Phase 1
7 Peripheral Nervous System Agents Phase 1
8 Phosphodiesterase Inhibitors Phase 1
9
Erlotinib Hydrochloride Phase 1 183319-69-9 176871
10 Protein Kinase Inhibitors Phase 1
11 Vasodilator Agents Phase 1
12 Anti-Asthmatic Agents Phase 1
13 Autonomic Agents Phase 1
14 Bronchodilator Agents Phase 1
15
Sucralfate Approved 54182-58-0
16 Gastrointestinal Agents
17 Antacids
18 Anti-Ulcer Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Two-Part Trial to Evaluate the Efficacy, Safety, and Tolerability of iOWH032 in the Treatment of Acute Dehydrating Diarrhea in Adult and Pediatric Patients With Cholera Withdrawn NCT02111304 Phase 2 iOWH032
2 A Phase I, Single-center, Non-randomized, Open-label Study to Determine the Lowest Effective Theophylline Dose That Decreased Erlotinib's Diarrhea at the Standard Dose of 150 mg/Day and to Determine the Highest Erlotinib Dose in Combination With Theophylline That Can be Administered to Patients Terminated NCT02080078 Phase 1 Theophylline;Erlotinib
3 Parasitic Causes of Secretory Diarrhea in Children and Chronically Ill Adult. Unknown status NCT03166670
4 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Unknown status NCT03261297
5 Treatment and Prevention of Oral and Alimentary Mucositis Using Polymerized Cross-Linked High Potency Sucralfate as a Single Agent Therapy Unknown status NCT02016807
6 Protective Immunity to Human Cholera in Bangladesh-EGD Substudy Completed NCT00349999

Search NIH Clinical Center for Secretory Diarrhea

Genetic Tests for Secretory Diarrhea

Anatomical Context for Secretory Diarrhea

MalaCards organs/tissues related to Secretory Diarrhea:

41
Colon, Small Intestine, Liver, Kidney, Bone, Bone Marrow, Heart

Publications for Secretory Diarrhea

Articles related to Secretory Diarrhea:

(show top 50) (show all 544)
# Title Authors PMID Year
1
Microvillous Inclusion Disease as a Cause of Protracted Diarrhea. 38
31049800 2019
2
Microgels Sopping Up Toxins-GM1a-Functionalized Microgels as Scavengers for Cholera Toxin. 38
31265226 2019
3
Application of Whole Exome Sequencing in Congenital Secretory Diarrhea Diagnosis. 38
30633106 2019
4
Pancreatic neuroendocrine microadenomatosis presenting as a functional VIPoma. 38
31275551 2019
5
Capsaicin inhibitory effects on Vibrio cholerae toxin genes expression. 38
31143687 2019
6
Synthesis and Pharmacological Screening of Pyridopyrimidines as Effective Anti-Diarrheal Agents through the Suppression of Cyclic Nucleotide Accumulation. 38
31008011 2019
7
Lysophosphatidic acid type 2 receptor agonists in targeted drug development offer broad therapeutic potential. 38
30692142 2019
8
A Rare Case of Acute Kidney Injury: McKittrick Wheelock Syndrome. 38
30988251 2019
9
Case Report on a Rare Disease in Lithuania: Congenital Chloride Diarrhea. 38
30775050 2019
10
Antidiarrheal activity of α-terpineol in mice. 38
30540974 2019
11
Adenylyl cyclase 6 expression is essential for cholera toxin-induced diarrhea. 38
30624615 2019
12
Synthesis of phenylpyrimidinones as guanylyl cyclase C inhibitors. 38
30782244 2019
13
Chronic Diarrhea Secondary to Newly Diagnosed VIPoma. 38
31123451 2019
14
Modifications of cholera toxin subunit B binding to human large intestinal epithelium. An immunohistochemical study. 38
30145256 2018
15
Visualization-assisted binning of metagenome assemblies reveals potential new pathogenic profiles in idiopathic travelers' diarrhea. 38
30409177 2018
16
Antidiarrheal activity of a novel sulfated polysaccharide from the red seaweed Gracilaria cervicornis. 38
29803569 2018
17
Prevention and treatment of secretory diarrhea by the lysophosphatidic acid analog Rx100. 38
30253666 2018
18
Barrett's esophagus in children: what is the evidence? 38
29992379 2018
19
AC6 is the major adenylate cyclase forming a diarrheagenic protein complex with cystic fibrosis transmembrane conductance regulator in cholera. 38
29903911 2018
20
Slc26a3 deficiency is associated with epididymis dysplasia and impaired sperm fertilization potential in the mouse. 38
30118583 2018
21
PERIPHERAL RETINAL DRUSEN-LIKE DEPOSITS IN GUCY2C CONGENITAL SECRETORY DIARRHEA SYNDROME. 38
29979251 2018
22
Peptide inhibitors of chloride channels for treating secretory diarrhea. 38
29772528 2018
23
Application of the biotin-labeled toxin mutant for affinity isolation of associated proteins in the mammalian cells. 38
29291913 2018
24
Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. 38
29653944 2018
25
Congenital sodium diarrhea and chorioretinal coloboma with optic disc coloboma in a patient with biallelic SPINT2 mutations, including p.(Tyr163Cys). 38
29575628 2018
26
Resveratrol dimer trans-ε-viniferin prevents rotaviral diarrhea in mice by inhibition of the intestinal calcium-activated chloride channel. 38
29155014 2018
27
Apical Membrane Alterations in Non-intestinal Organs in Microvillus Inclusion Disease. 38
29218485 2018
28
McKittrick Wheelock Syndrome Treated by Transanal Minimally Invasive Surgery: A Single-Center Experience and Review of the Literature. 38
28657837 2018
29
Affinity capillary electrophoresis for the assessment of binding affinity of carbohydrate-based cholera toxin inhibitors. 38
28905402 2018
30
Zinc strengthens the jejunal barrier by reversibly tightening the paracellular route. 38
28864501 2017
31
Enterotoxigenic Escherichia coli targeting intestinal epithelial tight junctions: An effective way to alter the barrier integrity. 38
29079214 2017
32
Secretory diarrhea and hypokalemia associated with colonic pseudo-obstruction: A case study and systematic analysis of the literature. 38
28580600 2017
33
The Botanical Drug Substance Crofelemer as a Model System for Comparative Characterization of Complex Mixture Drugs. 38
28743606 2017
34
ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice. 38
28895923 2017
35
Roflumilast reverses CFTR-mediated ion transport dysfunction in cigarette smoke-exposed mice. 38
28923049 2017
36
Microvillus Inclusion Disease Variant in an Infant with Intractable Diarrhea. 38
29282386 2017
37
CFTR-NHERF2-LPA₂ Complex in the Airway and Gut Epithelia. 38
28869532 2017
38
Human rotavirus strain Wa downregulates NHE1 and NHE6 expressions in rotavirus-infected Caco-2 cells. 38
28289928 2017
39
[Microvillous inclusion disease as a cause of severe congenital diarrhea. Case report]. 38
29546954 2017
40
Development and Validation of a Novel Real-time Assay for the Detection and Quantification of Vibrio cholerae. 38
28580353 2017
41
Verner-Morrison syndrome. Literature review. 38
28730220 2017
42
CFTR pharmacology. 38
27704174 2017
43
Celiac crisis in adults: a case report and review of the literature focusing in the prevention of refeeding syndrome. 38
26912167 2017
44
Anoctamin 6 Contributes to Cl- Secretion in Accessory Cholera Enterotoxin (Ace)-stimulated Diarrhea: AN ESSENTIAL ROLE FOR PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE (PIP2) SIGNALING IN CHOLERA. 38
27799301 2016
45
Pathogen-induced secretory diarrhea and its prevention. 38
27473379 2016
46
Cancer therapy-related complications in the bowel and mesentery: an imaging perspective. 38
27277528 2016
47
Malignant McKittrick-Wheelock syndrome as a cause of acute kidney injury and hypokalemia: Report of a case and review of literature. 38
27672546 2016
48
Identification of intestinal ion transport defects in microvillus inclusion disease. 38
27229121 2016
49
Alvocidib (flavopiridol) for the treatment of chronic lymphocytic leukemia. 38
26998706 2016
50
A case report of a giant rectal adenoma causing secretory diarrhea and acute renal failure: McKittrick-Wheelock syndrome. 38
27267899 2016

Variations for Secretory Diarrhea

Expression for Secretory Diarrhea

Search GEO for disease gene expression data for Secretory Diarrhea.

Pathways for Secretory Diarrhea

Pathways related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.01 SLC9A3 CFTR
2 10.68 SLC9A3 SLC26A3
3 10.17 SPINT2 CFTR

GO Terms for Secretory Diarrhea

Cellular components related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.13 SLC9A3 SLC26A3 CFTR
2 brush border membrane GO:0031526 8.62 SLC9A3 SLC26A3

Biological processes related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to cAMP GO:0071320 9.37 SLC26A3 CFTR
2 bicarbonate transport GO:0015701 9.32 SLC26A3 CFTR
3 digestion GO:0007586 9.26 SST GUCY2C
4 sperm capacitation GO:0048240 9.16 SLC26A3 CFTR
5 membrane hyperpolarization GO:0060081 8.96 SLC26A3 CFTR
6 intracellular pH elevation GO:0051454 8.62 SLC26A3 CFTR

Molecular functions related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antiporter activity GO:0015297 9.16 SLC9A3 SLC26A3
2 chloride transmembrane transporter activity GO:0015108 8.96 SLC26A3 CFTR
3 bicarbonate transmembrane transporter activity GO:0015106 8.62 SLC26A3 CFTR

Sources for Secretory Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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