MCID: SCR001
MIFTS: 40

Secretory Meningioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Secretory Meningioma

MalaCards integrated aliases for Secretory Meningioma:

Name: Secretory Meningioma 12 55 15 73
Meningioma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4588
MeSH 44 D008579
NCIt 50 C4718
SNOMED-CT 68 19453003 253081009
UMLS 73 C1384406

Summaries for Secretory Meningioma

MalaCards based summary : Secretory Meningioma, also known as meningioma, is related to solid adenocarcinoma with mucin production and papillary tumor of the pineal region. An important gene associated with Secretory Meningioma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The drugs Thrombin and Coagulants have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and endothelial, and related phenotype is neoplasm.

Related Diseases for Secretory Meningioma

Diseases related to Secretory Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 228)
# Related Disease Score Top Affiliating Genes
1 solid adenocarcinoma with mucin production 11.0 KRT7 MUC1
2 papillary tumor of the pineal region 11.0 MUC1 VIM
3 endosalpingiosis 11.0 KRT7 MUC1
4 ossifying fibromyxoid tumor 10.9 MUC1 VIM
5 middle ear adenoma 10.9 KRT7 MUC1
6 chordoid meningioma 10.9 MUC1 VIM
7 syringocystadenoma papilliferum 10.9 MUC1 VIM
8 eccrine porocarcinoma 10.9 MUC1 VIM
9 proliferating trichilemmal cyst 10.9 KRT7 KRT8
10 rhabdoid meningioma 10.9 NF2 VIM
11 endolymphatic sac tumor 10.9 KRT7 KRT8
12 transitional meningioma 10.9 MUC1 NF2
13 endometrial mucinous adenocarcinoma 10.9 MUC1 VIM
14 papillary adenoma 10.9 KRT7 VIM
15 cystic basal cell carcinoma 10.9 KRT20 KRT7
16 biphasic synovial sarcoma 10.9 MUC1 VIM
17 benign metastasizing leiomyoma 10.9 KRT7 VIM
18 seminal vesicle adenocarcinoma 10.8 KRT20 KRT7
19 transverse colon cancer 10.8 KRT20 KRT7
20 ovarian large-cell neuroendocrine carcinoma 10.8 KRT20 KRT7
21 apocrine adenocarcinoma 10.8 KRT7 MUC1
22 intravascular papillary endothelial hyperplasia 10.8 SERPINA3 VIM
23 eyelid neoplasm 10.8 KRT20 KRT7
24 malignant syringoma 10.8 KRT20 KRT7
25 hidrocystoma 10.8 KRT7 KRT8
26 krukenberg carcinoma 10.8 KRT20 KRT7
27 large intestine adenocarcinoma 10.8 KRT20 KRT7
28 parachordoma 10.8 KRT7 MUC1 VIM
29 linitis plastica 10.8 KRT20 KRT7
30 malignant mixed mullerian tumor 10.8 KRT7 MUC1 VIM
31 lung acinar adenocarcinoma 10.8 KRT20 KRT7
32 ovary neuroendocrine neoplasm 10.8 CDX2 KRT7
33 adenofibroma 10.8 MUC1 VIM
34 monophasic synovial sarcoma 10.8 KRT7 MUC1 VIM
35 small cell carcinoma of the bladder 10.8 KRT20 KRT7
36 spiradenoma 10.8 KRT7 MUC1 VIM
37 spindle cell sarcoma 10.8 KRT7 MUC1 VIM
38 malignant peritoneal mesothelioma 10.8 MUC1 NF2 VIM
39 eccrine sweat gland neoplasm 10.8 KRT20 KRT7
40 fibrous meningioma 10.8 MUC1 NF2 VIM
41 pancreatic intraductal papillary-mucinous neoplasm 10.8 MUC1 MUC2
42 goblet cell carcinoid 10.8 CEACAM7 KRT20
43 pericardial mesothelioma 10.8 KRT7 MUC1 VIM
44 epithelioid leiomyosarcoma 10.8 SERPINA3 VIM
45 myxopapillary ependymoma 10.8 MUC1 VIM
46 tumor of exocrine pancreas 10.8 MUC1 MUC2
47 apocrine sweat gland neoplasm 10.8 KRT7 KRT8
48 anaplastic ependymoma 10.8 MUC1 NF2 VIM
49 spindle cell carcinoma 10.8 KRT7 MUC1 VIM
50 acinar cell cystadenocarcinoma 10.8 SERPINA1 SERPINA3

Graphical network of the top 20 diseases related to Secretory Meningioma:



Diseases related to Secretory Meningioma

Symptoms & Phenotypes for Secretory Meningioma

MGI Mouse Phenotypes related to Secretory Meningioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.1 CDX2 KLF4 LGALS3 MUC2 NF2 PIK3CA

Drugs & Therapeutics for Secretory Meningioma

Drugs for Secretory Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 245)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 4
2 Coagulants Phase 4,Phase 3
3 Hemostatics Phase 4,Phase 3
4 Fibrin Tissue Adhesive Phase 4
5
Tranexamic Acid Approved Phase 3 1197-18-8 5526
6
Cisplatin Approved Phase 3,Phase 2 15663-27-1 84093 441203 2767
7
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
8
Mifepristone Approved, Investigational Phase 3 84371-65-3 55245
9
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
10
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
11
Donepezil Approved Phase 3,Phase 2,Early Phase 1 120014-06-4 3152
12
Ondansetron Approved Phase 3 99614-02-5 4595
13
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
14
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
15
Cyproheptadine Approved Phase 3 129-03-3 2913
16
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
17
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
18 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
19 Gastrointestinal Agents Phase 3,Phase 2,Phase 1,Not Applicable
20 Dermatologic Agents Phase 3,Phase 2,Phase 1
21 Antifibrinolytic Agents Phase 3
22 Liver Extracts Phase 3,Phase 1,Phase 2
23 Progestins Phase 3
24 Dexamethasone acetate Phase 3,Phase 1 1177-87-3
25 Analgesics Phase 3,Phase 2,Phase 1
26 glucocorticoids Phase 3,Phase 1
27 Central Nervous System Depressants Phase 3,Phase 2,Phase 1,Not Applicable
28 Adjuvants, Anesthesia Phase 3
29 Central Nervous System Stimulants Phase 3,Phase 2
30 Cholinergic Agents Phase 3,Phase 2,Early Phase 1
31 Cholinesterase Inhibitors Phase 3,Phase 2,Early Phase 1
32 Narcotics Phase 3
33 Contraceptive Agents Phase 3
34 Contraceptives, Oral Phase 3
35 Contraceptives, Postcoital Phase 3
36 Neurotransmitter Agents Phase 3,Phase 2,Phase 1,Early Phase 1
37 Analgesics, Opioid Phase 3
38 Anesthetics Phase 3,Not Applicable
39 Nootropic Agents Phase 3,Phase 2,Early Phase 1
40 Hormone Antagonists Phase 3,Phase 2,Phase 1,Not Applicable
41 Anesthetics, General Phase 3
42 Anesthetics, Intravenous Phase 3
43 Hormones Phase 3,Phase 2,Phase 1,Not Applicable
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1,Not Applicable
45 Emetics Phase 3
46 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Not Applicable
47 Antiemetics Phase 3,Phase 1
48 Luteolytic Agents Phase 3
49 BB 1101 Phase 3,Phase 1
50 Autonomic Agents Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 184)
# Name Status NCT ID Phase Drugs
1 Phase IV Bioseal Study in Brain Tumor Surgery Completed NCT02034799 Phase 4
2 Cavernous Sinus Dissection and Bleeding in Meningiomas Recruiting NCT02863484 Phase 4
3 Neurocognitive Outcome Assesment in Patients With Peri-optic Meningiomas After Excision With Or Without Pealing Of The Outer Layer Of The Cavernous Sinus: A Randomized Controlled Single Blinded Trial. Not yet recruiting NCT03190122 Phase 4
4 SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors Unknown status NCT00517959 Phase 3
5 Efficacy of Tranexamic Acid in Brain Tumor Resections Unknown status NCT01655927 Phase 3 Tranexamic Acid;Placebo: Saline
6 S9005 Mifepristone in Meningioma Completed NCT03015701 Phase 3 Mifepristone
7 Proton/Photon Rt - Benign Meningiomas(P92-13) Completed NCT02947984 Phase 3
8 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
9 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
10 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
11 Magnesium and Intraoperative Blood Loss in Meningioma Surgery Not yet recruiting NCT03558516 Phase 3 Magnesium group;Normal saline group
12 Radiotherapy or Radiosurgery Compared With Observation Alone in Treating Patients With Newly Diagnosed, Benign Meningioma That Has Been Partially Removed by Surgery Terminated NCT00104936 Phase 3
13 Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
14 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
15 Combination of Everolimus and Octreotide LAR in Aggressive Recurrent Meningiomas Unknown status NCT02333565 Phase 2 Everolimus;Octreotide
16 Hydroxyurea With or Without Imatinib Mesylate in Treating Patients With Recurrent or Progressive Meningioma Unknown status NCT00904735 Phase 2 hydroxyurea;imatinib mesylate
17 Hydroxyurea in Treating Patients With Recurrent and/or Unresectable Meningioma Unknown status NCT00006119 Phase 2 hydroxyurea
18 Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas Unknown status NCT01024907 Phase 1, Phase 2
19 Monthly SOM230C for Recurrent or Progressive Meningioma Completed NCT00859040 Phase 2 SOM230C
20 S9811 Hydroxyurea in Treating Patients With Unresectable Benign Meningioma Completed NCT00003590 Phase 2 hydroxyurea
21 Combination of Hydroxyurea and Verapamil for Refractory Meningiomas Completed NCT00706810 Phase 2 Hydroxyurea;Verapamil
22 Interferon Alfa in Treating Patients With Recurrent Unresectable Meningiomas and Malignant Meningiomas Completed NCT00002965 Phase 2
23 Radiation Therapy in Treating Patients Who Have Undergone Surgery for Newly Diagnosed Grade II or Grade III Meningioma Completed NCT00626730 Phase 2
24 Imatinib Mesylate in Treating Patients With Recurrent Meningioma Completed NCT00045734 Phase 2 imatinib mesylate
25 Vatalanib in Treating Patients With Recurrent or Progressive Meningioma Completed NCT00348790 Phase 2 vatalanib
26 Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma Completed NCT00589784 Phase 2 Sunitinib
27 Imatinib Mesylate and Hydroxyurea in Treating Patients With Recurrent or Progressive Meningioma Completed NCT00354913 Phase 2 hydroxyurea;imatinib mesylate
28 Imatinib Mesylate in Treating Patients With Recurrent Malignant Glioma or Meningioma Completed NCT00010049 Phase 1, Phase 2 imatinib mesylate
29 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2 bevacizumab;placebo
30 Erlotinib in Treating Patients With Recurrent Malignant Glioma or Recurrent or Progressive Meningioma Completed NCT00045110 Phase 1, Phase 2 erlotinib hydrochloride
31 Gefitinib in Treating Patients With Recurrent or Progressive CNS Tumors Completed NCT00025675 Phase 2 gefitinib
32 Phase II Study of Everolimus (RAD001) in Children and Adults With Neurofibromatosis Type 2 Completed NCT01419639 Phase 2 Everolimus (RAD001) , Afinitor®
33 Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2) Completed NCT01207687 Phase 2
34 Irinotecan in Treating Children With Refractory Solid Tumors Completed NCT00004078 Phase 2 irinotecan hydrochloride
35 Bevacizumab and Irinotecan for Patients With Primary Brain Tumors and Progression After Standard Therapy Completed NCT00463203 Phase 2 Bevacizumab;Irinotecan
36 Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors Completed NCT01032200 Phase 2 Armodafinil
37 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2 levetiracetam;pregabalin
38 Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma Completed NCT00006102 Phase 2 becatecarin
39 Temozolomide Followed by Radiation Therapy in Treating Children With Newly Diagnosed Malignant CNS Tumors Completed NCT00005955 Phase 2 temozolomide
40 SU5416 in Treating Patients With Recurrent Astrocytoma or Mixed Glioma That Has Not Responded to Radiation Therapy Completed NCT00004868 Phase 1, Phase 2 semaxanib
41 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
42 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors Completed NCT00003461 Phase 1, Phase 2
43 Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
44 Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT00973739 Phase 2 Lapatinib
45 Vistusertib (AZD2014) For Recurrent Grade II-III Meningiomas Recruiting NCT03071874 Phase 2 AZD2014
46 Phase II Trial of Pembrolizumab in Recurrent or Residual High Grade Meningioma Recruiting NCT03279692 Phase 2 Pembrolizumab
47 A Study of Nivolumab in Adult Participants With Recurrent High-Grade Meningioma Recruiting NCT02648997 Phase 2 Nivolumab
48 Proton Radiation For Meningiomas and Hemangiopericytomas Recruiting NCT01117844 Phase 1, Phase 2
49 Optune Delivered Electric Field Therapy and Bevacizumab in Treating Patients With Recurrent or Progressive Grade 2 or 3 Meningioma Recruiting NCT02847559 Phase 2
50 Multisession Radiosurgery for Optic Nerve Sheath Meningiomas Recruiting NCT02594709 Phase 2

Search NIH Clinical Center for Secretory Meningioma

Genetic Tests for Secretory Meningioma

Anatomical Context for Secretory Meningioma

MalaCards organs/tissues related to Secretory Meningioma:

41
Brain, Bone, Endothelial, T Cells, Testes, Spinal Cord, Bone Marrow

Publications for Secretory Meningioma

Articles related to Secretory Meningioma:

(show all 36)
# Title Authors Year
1
Pearls & Oy-sters: Persistent elevation of serum carcinoembryonic antigen in secretory meningioma. ( 29438031 )
2018
2
The Possible Role of Mast Cells and VEGF in Peritumoural Oedema of Secretory Meningioma. ( 29901331 )
2016
3
Secretory meningioma with KLF4 K409Q mutation in collision with glioma. ( 26227255 )
2015
4
A Left Frontal Secretory Meningioma Can Mimic Transformed Migraine With and Without Aura. ( 26084240 )
2015
5
Crush Cytology of Secretory Meningioma: A Case Report. ( 26605274 )
2015
6
Secretory meningioma: a diagnostic pitfall. ( 24943746 )
2014
7
Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations. ( 23404370 )
2013
8
Skull base secretory meningioma. Value of histological and immunohistochemical findings for peritumoral brain edema formation. ( 23645307 )
2013
9
Secretory Meningioma Mimicking Malignancy. ( 27408092 )
2008
10
Immunohistochemical study of the extracellular matrix proteins laminin, fibronectin and type IV collagen in secretory meningiomas. ( 18474427 )
2008
11
Primary temporal bone secretory meningioma presenting as chronic otitis media. ( 18172659 )
2008
12
Secretory meningioma of the middle ear: a light microscopic, immunohistochemical and ultrastructural study of one case. ( 18181836 )
2008
13
Merlin expression in secretory meningiomas: evidence of an NF2-independent pathogenesis? Immunohistochemical study. ( 17721284 )
2007
14
Secretory meningioma: immunohistochemical findings and evaluation of mast cell infiltration. ( 16010579 )
2006
15
Anaplastic secretory meningioma: a case report. ( 16929789 )
2006
16
[Analysis of clinical and pathological features of secretory meningiomas]. ( 16761441 )
2006
17
Temporal bone secretory meningioma presenting as a middle ear mass. ( 16517091 )
2006
18
A rare case of recurrent secretory meningioma with malignant transformation. ( 16954080 )
2006
19
Metastasis of pulmonary adenocarcinoma in right sylvian secretory meningioma. ( 11926470 )
2002
20
[A rare case of tumor-to-tumor metastasis: secondary deposits of pulmonary adenocarcinoma in a secretory meningioma]. ( 12368922 )
2002
21
Secretory meningioma: clinicopathologic features of eight cases. ( 11437574 )
2001
22
Secretory meningiomas: clinical and immunohistochemical observations. ( 11220371 )
2001
23
Cytologic features of secretory meningioma. ( 10097697 )
1999
24
Secretory meningioma of the brain. Report of two cases. ( 10464426 )
1999
25
Secretory meningioma with lipomatous component: case report. ( 10746964 )
1999
26
Secretory meningioma, a rare meningioma subtype with characteristic glandular differentation: an histological and immunohistochemical study of 9 cases. ( 10655573 )
1999
27
Lipomatous secretory meningioma: case report and review of the literature. ( 9833895 )
1998
28
Secretory meningioma with severe perifocal edema--case report. ( 9301199 )
1997
29
Secretory meningioma: clinical, histologic, and immunohistochemical findings in 31 cases. ( 9149029 )
1997
30
Secretory meningioma--a case report with histopathological, immunohistochemical and ultrastructural analysis. ( 8878810 )
1996
31
Secretory meningioma: a case report with immunohistochemical and ultrastructural study. ( 8220795 )
1993
32
Secretory meningioma with elevated serum carcinoembryonic antigen level. ( 1631772 )
1992
33
Secretory meningioma. ( 1452131 )
1992
34
Secretory meningioma associated with numerous meningothelial rosettes. ( 1384270 )
1992
35
Pseudopsammomatous meningioma with elevated serum carcinoembryonic antigen: a true secretory meningioma. Case report. ( 1984492 )
1991
36
Secretory meningioma. A distinct subtype of meningioma. ( 2420220 )
1986

Variations for Secretory Meningioma

Expression for Secretory Meningioma

Search GEO for disease gene expression data for Secretory Meningioma.

Pathways for Secretory Meningioma

Pathways related to Secretory Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.59 KRT20 KRT7 KRT8 MUC1 NF2 VIM
2
Show member pathways
11.47 KRT7 KRT8 VIM
3 11.38 CDX2 KLF4 SERPINA1 VIM
4 10.92 CEACAM5 LGALS3 MUC1

GO Terms for Secretory Meningioma

Cellular components related to Secretory Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.92 KRT20 KRT7 KRT8 VIM

Biological processes related to Secretory Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.43 KRT20 KRT7 KRT8
2 intermediate filament organization GO:0045109 9.16 KRT20 VIM
3 negative regulation of anoikis GO:2000811 8.96 CEACAM5 PIK3CA
4 maintenance of gastrointestinal epithelium GO:0030277 8.62 MUC2 SERPINA3

Sources for Secretory Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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