MCID: SZR006
MIFTS: 56

Seizure Disorder

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Seizure Disorder

MalaCards integrated aliases for Seizure Disorder:

Name: Seizure Disorder 53 6 3
Seizures 29 6 42
Epilepsy 71
Seizure 29

Classifications:



External Ids:

UMLS 71 C0014544

Summaries for Seizure Disorder

NINDS : 53 The epilepsies are a spectrum of brain disorders ranging from severe, life-threatening and disabling, to ones that are much more benign. In epilepsy, the normal pattern of neuronal activity becomes disturbed, causing strange sensations, emotions, and behavior or sometimes convulsions, muscle spasms, and loss of consciousness. The epilepsies have many possible causes and there are several types of seizures. Anything that disturbs the normal pattern of neuron activity—from illness to brain damage to abnormal brain development—can lead to seizures. Epilepsy may develop because of an abnormality in brain wiring, an imbalance of nerve signaling chemicals called neurotransmitters, changes in important features of brain cells called channels, or some combination of these and other factors. Having a single seizure as the result of a high fever (called febrile seizure) or head injury does not necessarily mean that a person has epilepsy. Only when a person has had two or more seizures is he or she considered to have epilepsy. A measurement of electrical activity in the brain and brain scans such as magnetic resonance imaging or computed tomography are common diagnostic tests for epilepsy.

MalaCards based summary : Seizure Disorder, also known as seizures, is related to malignant migrating partial seizures of infancy and seizures, benign familial infantile, 3, and has symptoms including seizures, tremor and back pain. An important gene associated with Seizure Disorder is DIAPH1 (Diaphanous Related Formin 1), and among its related pathways/superpathways are Neuroscience and L1CAM interactions. The drugs Ethosuximide and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and cortex.

MedlinePlus : 42 Seizures are symptoms of a brain problem. They happen because of sudden, abnormal electrical activity in the brain. When people think of seizures, they often think of convulsions in which a person's body shakes rapidly and uncontrollably. Not all seizures cause convulsions. There are many types of seizures and some have mild symptoms. Seizures fall into two main groups. Focal seizures, also called partial seizures, happen in just one part of the brain. Generalized seizures are a result of abnormal activity on both sides of the brain. Most seizures last from 30 seconds to 2 minutes and do not cause lasting harm. However, it is a medical emergency if seizures last longer than 5 minutes or if a person has many seizures and does not wake up between them. Seizures can have many causes, including medicines, high fevers, head injuries and certain diseases. People who have recurring seizures due to a brain disorder have epilepsy. NIH: National Institute of Neurological Disorders and Stroke

CDC : 3 Epilepsy is a broad term used for a brain disorder that causes seizures. There are many different types of epilepsy. There are also many different kinds of seizures.

Wikipedia : 74 Epilepsy is a group of neurological disorders characterized by recurrent epileptic seizures. Epileptic... more...

Related Diseases for Seizure Disorder

Diseases in the Seizure Disorder family:

Seizures, Benign Familial Infantile, 1 Seizures, Benign Familial Infantile, 2
Seizures, Benign Familial Infantile, 3 Seizures, Benign Familial Infantile, 4
Seizures, Benign Familial Infantile, 5 Scn1a-Related Seizure Disorders

Diseases related to Seizure Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2985)
# Related Disease Score Top Affiliating Genes
1 malignant migrating partial seizures of infancy 34.1 SCN2A SCN1A
2 seizures, benign familial infantile, 3 33.8 SCN2A KCNQ2
3 febrile seizures, familial, 1 33.8 SCN2A SCN1A
4 febrile seizures, familial, 5 33.7 SCN2A SCN1A
5 febrile seizures, familial, 2 33.7 SCN2A SCN1A
6 benign neonatal seizures 33.4 SCN2A SCN1A KCNQ2
7 familial febrile seizures 33.3 SCN2A SCN1A
8 epileptic encephalopathy, early infantile, 14 32.8 SCN2A SCN1A
9 benign familial neonatal epilepsy 32.6 SCN2A SCN1A KCNQ2
10 benign familial infantile epilepsy 32.5 SCN2A SCN1A KCNQ2
11 epileptic encephalopathy, early infantile, 13 32.3 SCN2A SCN1A
12 genetic epilepsy with febrile seizures plus 32.1 SCN2A SCN1A
13 epilepsy, nocturnal frontal lobe, 1 32.0 SCN1A KCNQ2
14 early myoclonic encephalopathy 31.7 SCN2A SCN1A KCNQ2
15 paroxysmal extreme pain disorder 31.6 SCN2A SCN1A
16 epileptic encephalopathy, early infantile, 9 31.2 SCN1A KCNQ2
17 episodic ataxia 31.2 SCN2A SCN1A KCNQ2
18 epileptic encephalopathy, early infantile, 6 31.2 SCN2A SCN1A KCNQ2
19 partial motor epilepsy 31.1 SCN2A SCN1A KCNQ2
20 electroclinical syndrome 31.0 SCN2A SCN1A KCNQ2
21 epileptic encephalopathy, early infantile, 1 31.0 SCN1A KCNQ2
22 early onset absence epilepsy 31.0 SCN2A SCN1A KCNQ2
23 visual epilepsy 30.3 SCN2A SCN1A KCNQ2
24 low-grade astrocytoma 30.2 SCN2A SCN1A
25 febrile seizures 30.0 SCN2A SCN1A KCNQ2
26 hypertelorism 29.8 WHCR SCN1A
27 west syndrome 29.7 SCN2A SCN1A KCNQ2
28 status epilepticus 29.7 SCN1A KCNQ2
29 focal epilepsy 29.7 SCN2A SCN1A KCNQ2
30 lennox-gastaut syndrome 29.6 SCN2A SCN1A KCNQ2
31 migraine, familial hemiplegic, 3 29.6 SCN2A SCN1A
32 epilepsy with generalized tonic-clonic seizures 29.5 SCN2A SCN1A
33 epilepsy 29.5 SCN2A SCN1A KCNQ2 CILK1
34 migraine with aura 29.4 SCN1A MTR
35 episodic ataxia, type 1 29.3 SCN1A KCNQ2
36 benign epilepsy with centrotemporal spikes 29.3 SCN2A SCN1A KCNQ2
37 landau-kleffner syndrome 29.3 SCN2A SCN1A KCNQ2
38 generalized epilepsy with febrile seizures plus 29.2 SCN2A SCN1A KCNQ2
39 photosensitive epilepsy 29.0 SCN2A SCN1A KCNQ2
40 autosomal dominant nocturnal frontal lobe epilepsy 29.0 SCN2A SCN1A KCNQ2
41 migraine with or without aura 1 28.9 SCN2A SCN1A KCNQ2
42 childhood absence epilepsy 28.9 SCN2A SCN1A KCNQ2
43 epilepsy, idiopathic generalized 28.9 SCN2A SCN1A KCNQ2
44 epilepsy, myoclonic juvenile 28.8 SCN2A SCN1A KCNQ2 CILK1
45 early infantile epileptic encephalopathy 28.8 SCN2A SCN1A KCNQ2
46 pervasive developmental disorder 28.8 SCN2A SCN1A KCNQ2
47 multiple congenital anomalies-hypotonia-seizures syndrome 2 12.5
48 seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance 12.5
49 multiple congenital anomalies-hypotonia-seizures syndrome 1 12.5
50 multiple congenital anomalies-hypotonia-seizures syndrome 3 12.5

Comorbidity relations with Seizure Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Seizure Disorder:



Diseases related to Seizure Disorder

Symptoms & Phenotypes for Seizure Disorder

UMLS symptoms related to Seizure Disorder:


seizures, tremor, back pain, headache, syncope, pain, chronic pain, sciatica, vertigo/dizziness, sleeplessness, non-epileptic convulsion

Drugs & Therapeutics for Seizure Disorder

Drugs for Seizure Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 803)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethosuximide Approved Phase 4 77-67-8 3291
2
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
3
Nitrazepam Approved Phase 4 146-22-5 4506
4
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
5
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
6
Lumefantrine Approved Phase 4 82186-77-4 6437380
7
Artemether Approved Phase 4 71963-77-4 68911 9796294 119380
8
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
9
Verapamil Approved Phase 4 52-53-9 2520
10
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
11
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
12
Eslicarbazepine acetate Approved Phase 4 75970-99-9, 236395-14-5 123618
13
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
14
Morphine Approved, Investigational Phase 4 57-27-2 5288826
15
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
16
Methohexital Approved Phase 4 151-83-7 9034
17
Bupropion Approved Phase 4 34911-55-2, 34841-39-9 444
18
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
19
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
20
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
21
Nicotine Approved Phase 4 54-11-5 942 89594
22
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
23
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
24
Risedronate Approved, Investigational Phase 4 105462-24-6 5245
25
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
26
Labetalol Approved Phase 4 36894-69-6 3869
27
Ziprasidone Approved Phase 4 146939-27-7 60854
28
Cosyntropin Approved Phase 4 16960-16-0 16129617
29
Sodium citrate Approved, Investigational Phase 4 68-04-2
30
Vidarabine Approved, Investigational Phase 4 24356-66-9 21704 32326
31
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
32
Cycloserine Approved Phase 4 68-41-7 401 6234
33
Levodopa Approved Phase 4 59-92-7 6047
34
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
35
Cysteamine Approved, Investigational Phase 4 60-23-1 6058
36
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
37
Imipramine Approved Phase 4 50-49-7 3696
38
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
39
Norepinephrine Approved Phase 4 51-41-2 439260
40
Nortriptyline Approved Phase 4 72-69-5 4543
41
Hydralazine Approved Phase 4 86-54-4 3637
42
Clevidipine Approved, Investigational Phase 4 167221-71-8
43
Clonidine Approved Phase 4 4205-90-7 2803
44
Ticagrelor Approved Phase 4 274693-27-5 9871419
45
Pasireotide Approved Phase 4 396091-73-9 9941444
46
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
47
Liraglutide Approved Phase 4 204656-20-2 44147092
48
parecoxib Approved Phase 4 198470-84-7
49
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
50
Dobutamine Approved Phase 4 34368-04-2 36811

Interventional clinical trials:

(show top 50) (show all 3046)
# Name Status NCT ID Phase Drugs
1 Prospective Open Label Evaluation of Clobazam Adjunctive Treatment of Adults With Refractory Focal Epilepsy: A Pilot Study Unknown status NCT02726919 Phase 4 Clobazam
2 A Randomised Controlled Trial of the Ketogenic Diet in the Treatment of Epilepsy in Children Under the Age of Two Years Unknown status NCT02205931 Phase 4 Antiepileptic drug therapy
3 Study to Improve the Treatment of Epilepsy (SITE). A Randomized Study Comparing Adjustment of Treatment to Reduce Side Effects of Antiepileptic Drugs With Continuing Treatment Unchanged Unknown status NCT00133081 Phase 4 All registered antiepileptic drugs
4 Immunotherapy in Intractable Cryptogenic Epilepsy Patients With Autoimmune Antibody Unknown status NCT02695797 Phase 4 Prednisolone
5 Efficacy of Levetiracetam in Control of Neonatal Seizures Unknown status NCT03107507 Phase 4 Levetiracetam;Phenobarbital
6 The Impact of Reducing Overtreatment on Quality of Life in Children With Refractory Epilepsy Unknown status NCT00647322 Phase 4
7 Electroclinical Effect of Diazepam and Steroid in Patients With Benign Childhood Epilepsy With Centrotemporal Spikes Unknown status NCT03490487 Phase 4 conventional antiepileptic drugs;oral steroid;Diazepam
8 Comparing Ketogenic Diet With the Most Appropriate Antiepileptic Drug- a Randomized Study of Children With Mental Retardation and Drug Resistant Epilepsy Unknown status NCT00552526 Phase 4 Antiepileptic drug (AED)
9 A Randomized Controlled Trial of Generic Substitution of Antiepileptic Drugs Unknown status NCT02429596 Phase 4 Experimental
10 Double Blind, Randomised, Cross-over Study Melatonin Versus Placebo in the Lennox-Gastaut Syndrome: Neurophysiological and Neuropsychological Effects Unknown status NCT01370486 Phase 4 melatonin;placebo
11 Hormone Profiles in Adults Treated With Valproate vs. Lamotrigine Monotherapy for Newly Diagnosed Epilepsy: A Prospective Randomised Study Unknown status NCT00137709 Phase 4 Sodium valproate;Lamotrigine
12 Levetiracetam Treatment of Children With Subclinical Sleep-Activated Epileptiform Activity (SSEA) - a Placebo Controlled Double-blind Cross-over-study Unknown status NCT00393614 Phase 4 levetiracetam
13 Evaluation of Onfi Conversion Therapy Replacing Clonazepam in Patients With Medically Refractory Epilepsy: Efficacy, Tolerability, Dosing Equivalence, and Retention Rate Unknown status NCT01932502 Phase 4 clobazam (Onfi);Initial conversion and titration;Conversion schedule - Week 1;Conversion schedule - Week 2;Conversion schedule - Week 3
14 Hyperventilation and ECT Seizure Duration: Effects on Cerebral Oxygen Saturation, and Therapeutic Outcome With Comparisons Between Etomidate and Ketamine in Patients With Major Depressive Disorder Unknown status NCT02924090 Phase 4 Etomidate;Ketamine
15 Effects of Perampanel on Cognition and Electroencephalography in Patients With Epilepsy Unknown status NCT02900755 Phase 4 Perampanel
16 Melatonin Use in the Intensive Care Elderly Population Unknown status NCT03013790 Phase 4 Melatonin
17 Combining Propofol With Therapeutic Hypothermia for Improving Survival and Neurological Prognoses in Patients Resuscitated From Cardiac Arrest Unknown status NCT02367755 Phase 4 Propofol;Lorazepam
18 Turgut Ozal Medical Center Department of Anesthesiology and Reanimation Unknown status NCT02267980 Phase 4 Sevoflurane;Ketamine;Saline
19 Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. A Multi-center Comparative Randomized Double-blind and Placebo-controlled Clinical Trial Unknown status NCT01478035 Phase 4 Phenytoin;placebo
20 Inonu University, Turgut Ozal Medical Center, Department of Anesthesiology and Reanimation Malatya Unknown status NCT02271555 Phase 4 Sevoflurane;Remifentanil;Saline
21 The Benefit of Prophylactic Anticonvulsant in Post Cardiac Arrest Syndrome With Induced Mild Hypothermia Unknown status NCT01083784 Phase 4 Use of prophylactic anticonvulsants (valproate, clonazepam);Control group
22 Conversion From Multiple-Daily Dose Enteric-Coated Depakote to Once-Daily Depakote ER in Elderly Outpatients With Epilepsy or Behavioral Disturbances: Unknown status NCT00312676 Phase 4
23 Relationship Between Topiramate Use and Ocular Angle Status: A Prospective Pilot Study Unknown status NCT00153699 Phase 4 Topiramate
24 Effects on the Diagnostic Accuracy of Magnetic Imaging Angiographies of the Supra-Aortic Vessels by Three Different Magnetic Resonance Contrast Agents in Patients With Headache and Dizziness or Epilepsy and Clinical Indication for an Angiography by Magnetic Imaging Unknown status NCT00132223 Phase 4 Contrast agent
25 Buccal Midazolam Versus Nasal or Oral Midazolam Sedation for Minor Invasive Procedures in Children: A Prospective Randomized Control Study Unknown status NCT02408302 Phase 4 Midazolam
26 Open Label Study of Milnacipran in the Preventive Treatment of Episodic Migraine With and Without Aura and Chronic Migraine. Unknown status NCT01319825 Phase 4 milnacipran
27 Comparison of Oral 30 % Dextrose and iv Midazolam Sedation During MRI in Neonates Unknown status NCT02645279 Phase 4 IV midazolam
28 A Randomized Controlled Trial Comparing the Adductor Canal Catheter (ACC) and Intra-articular Catheter (IAC) Following Primary Total Knee Arthroplasty Unknown status NCT02497911 Phase 4 Ropivicaine;Bupivicaine
29 The Effect of Central Insulin on Insulin Sensitivity and Energy Metabolism Unknown status NCT01479075 Phase 4 intransal insulin;Placebo
30 A Double-Blinded Randomized Controlled Trial Comparing the Adductor Canal Catheter (ACC) and Local Infiltration of Analgesia (LIA) Following Primary Total Knee Arthroplasty Unknown status NCT02603900 Phase 4 ropivacaine;bupivacaine
31 The Safety and Immunogenicity Study of Rotavirus Vaccine Simultaneously Vaccinated With MR or MMR Vaccine Unknown status NCT02153866 Phase 4
32 Pharmacokinetic/Pharmacodynamic Model of Propofol in Children Unknown status NCT02544854 Phase 4 Propofol
33 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Unknown status NCT02920593 Phase 4 Vitamin D3
34 Morphine Versus Methadone for Opiate Exposed Infants With Neonatal Abstinence Syndrome Unknown status NCT02851303 Phase 4 Morphine;Methadone
35 Treatment With Acetyl-Choline Esterase Inhibitors in Children With Autism Unknown status NCT01098383 Phase 4 Acetyl-Choline Esterase Inhibitors and Choline supplements;Indistinguishable placebo tablets, matching both donepezil and choline
36 Effect of Bispectral Index (BIS) Monitoring on Faster Recovery Time and Analgesic Consumption in Abdominal Surgery Patients Unknown status NCT01470898 Phase 4
37 Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive Therapy Unknown status NCT02579642 Phase 4 Ketamine;Placebo
38 DDAVP vs Exercise in Patients With Mild Hemophilia A - Which is Better and do They Work Synergistically in Improving Hemostasis? Unknown status NCT03136003 Phase 4 DDAVP
39 Prospective Assessment of Valproate on Ethanol Withdrawal Unknown status NCT03235531 Phase 4 Valproate;Lorazepam
40 Evaluation Whether Higher Retention Rate is in Those of Combined Methadone With N-Acetyl-Cysteine Compared to Those With Methadone Alone During a Six-month Study Unknown status NCT01047956 Phase 4 Methadone; NAC;Methadone
41 Antispastic Effect of Transcranial Magnetic Stimulation in Patients With Cerebral and Spinal Spasticity Unknown status NCT01786005 Phase 4
42 Efficacy and Safety of Artemether + Lumefantrine and Dihydroartemisinin + Piperaquine for the Treatment of Uncomplicated Malaria in Guinea-Bissau. Unknown status NCT01704508 Phase 4 Artemether-lumefantrine;Dihydroartemisinin-piperaquine
43 A Randomized, Open Label, Comparative, Multi-center Clinical Trial to Determine the Efficacy and Safety of Topiramate Comparing With Carbamazepine in Benign Rolandic Epilepsy. Completed NCT00216567 Phase 4 topamax
44 A 24-Week Prospective, Open-Label, Multicenter Study to Evaluate the Effect on Seizure Frequency, Safety and Tolerability of Oxcarbazepine Monotherapy in Adult Patients With Partial Seizures Completed NCT00275925 Phase 4 Oxcarbazepine
45 A Randomized, Double-blind, Parallel-group Multi-center Comparative Flexible-dose Trial Of Pregabalin Versus Gabapentin As Adjunctive Therapy In Subjects With Partial Seizures. Completed NCT00537940 Phase 4 Pregabalin;Gabapentin
46 A 24-week Prospective Open-label Multicenter Study to Evaluate the Effect on Seizure Frequency, Safety and Tolerability of Oxcarbazepine Monotherapy in Children With Partial Seizures Completed NCT00275912 Phase 4 Oxcarbazepine
47 OAETREAT Extra Ivermectin Treatment of Persons With Onchocerciasis-associated Epilepsy: a Completed NCT03852303 Phase 4 ivermectin
48 A Korean Open-label, Multi-center, Community-based Trial Assessing the Efficacy and Safety of Zonisamide as Adjunctive Therapy in Patients With Uncontrolled Partial Epilepsy Completed NCT01140867 Phase 4 zonisamide
49 IV Keppra in the Emergency Department for Prevention of Early Recurrent Seizures Completed NCT00510783 Phase 4 Keppra;Fosphenytoin;Dilantin
50 A Randomized, Open-label, Parallel Group, Multi-center, Comparative, Phase IV Trial of Levetiracetam (LEV) Versus Topiramate (TPM) as Adjunctive Therapy to Evaluate Efficacy and Safety in Subjects With Refractory Partial Onset Seizures Completed NCT01229735 Phase 4 Levetiracetam;Topiramate

Search NIH Clinical Center for Seizure Disorder

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Anti-epileptic Agent [EPC]
Divalproex Sodium
Ethosuximide
Ethotoin
felbamate
fosphenytoin
Fosphenytoin sodium
gabapentin
gabapentin enacarbil
lacosamide
lamotrigine
Levetiracetam
Mephenytoin
methsuximide
oxcarbazepine
Phenytoin
Phenytoin sodium
PHENYTOIN SODIUM,EXTENDED
PHENYTOIN SODIUM,PROMPT
Primidone
Sodium Valproate
tiagabine
Tiagabine hydrochloride
topiramate
Trimethadione
Valproic Acid
Vigabatrin
zonisamide

Genetic Tests for Seizure Disorder

Genetic tests related to Seizure Disorder:

# Genetic test Affiliating Genes
1 Seizures 29
2 Seizure 29

Anatomical Context for Seizure Disorder

MalaCards organs/tissues related to Seizure Disorder:

40
Brain, Temporal Lobe, Cortex, Testes, Amygdala, Heart, Bone

Publications for Seizure Disorder

Articles related to Seizure Disorder:

(show top 50) (show all 31725)
# Title Authors PMID Year
1
BET 2: Is keeping the eyes shut while fitting predictive of a psychogenic cause for seizures? 61 42
31848267 2020
2
Central-Positive Complexes: A Novel Characterization of Ictal Markers Induced During Electroconvulsive Therapy. 42 61
31764454 2019
3
Dravet syndrome: Treatment options and management of prolonged seizures. 61 42
31904119 2019
4
Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial. 61
31862249 2020
5
MS275 reduces seizure-induced brain damage in developing rats by regulating p38 MAPK signaling pathways and epigenetic modification. 61
32522630 2020
6
PARS2-associated mitochondrial disease: A case report of a patient with prolonged survival and literature review. 61
32514400 2020
7
CE-MS metabolic profiling of volume-restricted plasma samples from an acute mouse model for epileptic seizures to discover potentially involved metabolomic features. 61
32498853 2020
8
Functional seizures? "So I still have seizures, right?" 61
32451248 2020
9
The role of Orexin-A levels in epileptic seizure. 61
32485288 2020
10
Terminology for psychogenic nonepileptic seizures: The contribution of neuroimaging. 61
32249033 2020
11
Acute symptomatic seizures following intracerebral hemorrhage in the rat collagenase model. 61
32497986 2020
12
Predictors of drug-resistance in epilepsy with auditory features. 61
32447239 2020
13
Epilepsy self-management behaviors among African Americans with epilepsy. 61
32376207 2020
14
Differentiating psychogenic nonepileptic from epileptic seizures: A mixed-methods, content analysis study. 61
32388401 2020
15
Effects of erythropoietin pretreatment on single dose pentylentetrazole-induced seizures in rats. 61
32003592 2020
16
Efficacy of hypothermia therapy in patients with acute encephalopathy with biphasic seizures and late reduced diffusion. 61
32279899 2020
17
Reply to: We need a functioning name for PNES: Considering dissociative seizures. 61
32317162 2020
18
REM-sleep related hypermotor seizures: Video documentation and ictal source imaging. 61
32340922 2020
19
Characteristics of visual evoked potentials related to the electro-clinical expression of reflex seizures in photosensitive patients with idiopathic occipital lobe epilepsy. 61
32388124 2020
20
A survey of physicians' opinions about functional seizures (psychogenic nonepileptic seizures). 61
32320920 2020
21
CRISPR/dCas9-based Scn1a gene activation in inhibitory neurons ameliorates epileptic and behavioral phenotypes of Dravet syndrome model mice. 61
32445790 2020
22
Case-control association study of rare nonsynonymous variants of SCN1A and KCNQ2 in acute encephalopathy with biphasic seizures and late reduced diffusion. 61
32276107 2020
23
GABRG2 Deletion Linked to Genetic Epilepsy with Febrile Seizures Plus Affects the Expression of GABAA Receptor Subunits and Other Genes at Different Temperatures. 61
32418750 2020
24
Seizures associated with coronavirus infections. 61
32416567 2020
25
SARS-CoV-2 can induce brain and spine demyelinating lesions. 61
32367205 2020
26
Absence seizure provocation during routine EEG: Does position of the child during hyperventilation affect the diagnostic yield? 61
32446208 2020
27
Seizure occurrence in myelin oligodendrocyte glycoprotein antibody-associated disease: A systematic review and meta-analysis. 61
32222694 2020
28
Factors associated with subjective cognitive function in epilepsy and psychogenic non-epileptic seizures. 61
32353671 2020
29
Efficacy and tolerability of treatment with lacosamide in children: Postmarketing experience from the Middle East. 61
32422546 2020
30
Hypophosphatemia compared to classical biomarkers of tonic clonic seizures. 61
32305859 2020
31
Tuberous sclerosis complex associated intracranial lesion found by antenatal ultrasound. 61
32346461 2020
32
Seizures and Epilepsy in Autism Spectrum Disorder. 61
32471597 2020
33
Dramatic Improvement in Seizures With Phenytoin Treatment in an Individual With Refractory Epilepsy and a SCN1B Variant. 61
32303391 2020
34
Glutamatergic pathway in depressive-like behavior associated with pentylenetetrazole rat model of epilepsy with history of prolonged febrile seizures. 61
32376271 2020
35
Electrical Cortical Stimulation: Mapping for Function and Seizures. 61
32475491 2020
36
Electrographic Seizures and Brain Injury in Children Requiring Extracorporeal Membrane Oxygenation. 61
32299743 2020
37
"Negative T2 shine through" in patients with hyperglycemia and seizures: a frequently overlooked MRI pattern. 61
32219491 2020
38
Recurrent seizures cause immature brain injury and changes in GABA a receptor α1 and γ2 subunits. 61
32283447 2020
39
Driving rate and road traffic accidents in drivers with functional (psychogenic nonepileptic) seizures. 61
32408106 2020
40
The Humanistic and Economic Burden of Pediatric Focal Seizures in the United States. 61
32223583 2020
41
Cross-database evaluation of EEG based epileptic seizures detection driven by adaptive median feature baseline correction. 61
32417698 2020
42
Tranexamic acid administration during total joint arthroplasty surgery is not associated with an increased risk of perioperative seizures: a national database analysis. 61
32381731 2020
43
Self-Report questionnaires for the diagnosis of psychogenic non-epileptic seizures in clinical practice. A comprehensive review of the available instruments. 61
32417685 2020
44
Networks in Posterior Cortex Epilepsies. 61
32475483 2020
45
Seizures secondary to zolpidem withdrawal. 61
32543994 2020
46
Withdrawal seizures: possible risk factors. 61
32515638 2020
47
Cardiovascular complications of epileptic seizures. 61
32554232 2020
48
Role of Adenosine in Epilepsy and Seizures. 61
32566903 2020
49
Astrocytic modulation of potassium under seizures. 61
31823867 2020
50
Long-term outcomes after epilepsy surgery, a retrospective cohort study linking patient-reported outcomes and routine healthcare data. 61
32554230 2020

Variations for Seizure Disorder

ClinVar genetic disease variations for Seizure Disorder:

6 ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 MTR NM_000254.2(MTR):c.3518C>T (p.Pro1173Leu)SNV Pathogenic/Likely pathogenic 14278 rs121913578 1:237058770-237058770 1:236895470-236895470
2 DIAPH1 NM_005219.5(DIAPH1):c.2332C>T (p.Gln778Ter)SNV Pathogenic/Likely pathogenic 183344 rs730882242 5:140953085-140953085 5:141573518-141573518
3 SCN1A NM_001165963.4(SCN1A):c.1625G>A (p.Arg542Gln)SNV Conflicting interpretations of pathogenicity 68588 rs121918817 2:166901590-166901590 2:166045080-166045080
4 CAD NM_004341.5(CAD):c.6020T>C (p.Leu2007Pro)SNV Uncertain significance 830364 2:27464915-27464915 2:27242047-27242047

Expression for Seizure Disorder

Search GEO for disease gene expression data for Seizure Disorder.

Pathways for Seizure Disorder

Pathways related to Seizure Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.87 SCN2A SCN1A KCNQ2
2
Show member pathways
11.23 SCN2A SCN1A KCNQ2
3
Show member pathways
11.13 SCN2A SCN1A
4 10.28 SCN2A SCN1A KCNQ2

GO Terms for Seizure Disorder

Cellular components related to Seizure Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T-tubule GO:0030315 9.37 SCN2A SCN1A
2 intercalated disc GO:0014704 9.32 SCN2A SCN1A
3 axon initial segment GO:0043194 9.26 SCN1A KCNQ2
4 voltage-gated sodium channel complex GO:0001518 9.16 SCN2A SCN1A
5 sodium channel complex GO:0034706 8.96 SCN2A SCN1A
6 node of Ranvier GO:0033268 8.8 SCN2A SCN1A KCNQ2

Biological processes related to Seizure Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.5 SCN2A MTR KCNQ2
2 sodium ion transmembrane transport GO:0035725 9.26 SCN2A SCN1A
3 neuronal action potential GO:0019228 9.16 SCN2A SCN1A
4 membrane depolarization during action potential GO:0086010 8.96 SCN2A SCN1A
5 regulation of ion transmembrane transport GO:0034765 8.8 SCN2A SCN1A KCNQ2

Molecular functions related to Seizure Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cation channel activity GO:0005261 9.32 SCN2A SCN1A
2 sodium channel activity GO:0005272 9.26 SCN2A SCN1A
3 voltage-gated sodium channel activity GO:0005248 9.16 SCN2A SCN1A
4 ion channel activity GO:0005216 9.13 SCN2A SCN1A KCNQ2
5 voltage-gated ion channel activity GO:0005244 8.8 SCN2A SCN1A KCNQ2

Sources for Seizure Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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