MCID: SLC026
MIFTS: 26

Selection of Therapeutic Option in Colorectal Cancer

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Selection of Therapeutic Option in Colorectal Cancer

MalaCards integrated aliases for Selection of Therapeutic Option in Colorectal Cancer:

Name: Selection of Therapeutic Option in Colorectal Cancer 60

Classifications:



External Ids:

Orphanet 60 ORPHA357194

Summaries for Selection of Therapeutic Option in Colorectal Cancer

MalaCards based summary : Selection of Therapeutic Option in Colorectal Cancer is related to schimmelpenning-feuerstein-mims syndrome and acneiform dermatitis. Among its related pathways/superpathways are Integrin Pathway and Cytokine Signaling in Immune system. Affiliated tissues include thyroid, skin and liver, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Selection of Therapeutic Option in Colorectal Cancer

Diseases related to Selection of Therapeutic Option in Colorectal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 schimmelpenning-feuerstein-mims syndrome 10.0 KRAS NRAS
2 acneiform dermatitis 10.0 KRAS NRAS
3 ras-associated autoimmune leukoproliferative disorder 10.0 KRAS NRAS
4 core binding factor acute myeloid leukemia 10.0 KRAS NRAS
5 liver angiosarcoma 10.0 KRAS NRAS
6 nevus, epidermal 10.0 KRAS NRAS
7 acral lentiginous melanoma 9.9 BRAF NRAS
8 erdheim-chester disease 9.9 BRAF NRAS
9 autoimmune lymphoproliferative syndrome 9.9 KRAS NRAS
10 mucosal melanoma 9.9 BRAF NRAS
11 urachal adenocarcinoma 9.9 BRAF KRAS
12 hyperplastic polyposis syndrome 9.9 BRAF KRAS
13 langerhans cell histiocytosis 9.8 BRAF NRAS
14 mature teratoma 9.8 BRAF KRAS
15 skin melanoma 9.8 BRAF NRAS
16 colonic benign neoplasm 9.8 BRAF KRAS
17 pilocytic astrocytoma 9.8 BRAF KRAS
18 villous adenoma 9.8 BRAF KRAS
19 ovarian serous cystadenocarcinoma 9.8 BRAF NRAS
20 adenoma 9.8 BRAF KRAS
21 renal cell carcinoma, papillary, 1 9.8 BRAF NRAS
22 pilomyxoid astrocytoma 9.8 BRAF KRAS
23 melanoma, uveal 9.8 BRAF NRAS
24 pulmonic stenosis 9.8 BRAF KRAS
25 adrenocortical carcinoma, hereditary 9.8 BRAF NRAS
26 cardiofaciocutaneous syndrome 1 9.8 BRAF KRAS
27 thyroid cancer, nonmedullary, 2 9.8 BRAF NRAS
28 colorectal adenocarcinoma 9.8 BRAF KRAS
29 melanoma, cutaneous malignant 1 9.7 BRAF NRAS
30 lynch syndrome 9.7 BRAF KRAS
31 gastrointestinal stromal tumor 9.7 BRAF KRAS
32 hypertrophic cardiomyopathy 9.6 BRAF KRAS
33 cholangiocarcinoma 9.6 BRAF KRAS
34 leukemia, chronic lymphocytic 2 9.6 BRAF KRAS NRAS
35 leukemia, chronic lymphocytic 9.6 BRAF KRAS NRAS
36 differentiated thyroid carcinoma 9.6 BRAF KRAS NRAS
37 juvenile myelomonocytic leukemia 9.6 BRAF KRAS NRAS
38 bladder urothelial carcinoma 9.6 BRAF KRAS NRAS
39 myeloma, multiple 9.6 BRAF KRAS NRAS
40 adamantinoma of long bones 9.6 BRAF KRAS
41 noonan syndrome 1 9.6 BRAF KRAS NRAS
42 large intestine cancer 9.6 BRAF KRAS NRAS
43 gastric adenocarcinoma 9.5 BRAF KRAS NRAS
44 lung cancer susceptibility 3 9.5 BRAF KRAS NRAS
45 thyroid cancer 9.5 BRAF KRAS NRAS
46 lung squamous cell carcinoma 9.4 BRAF KRAS

Graphical network of the top 20 diseases related to Selection of Therapeutic Option in Colorectal Cancer:



Diseases related to Selection of Therapeutic Option in Colorectal Cancer

Symptoms & Phenotypes for Selection of Therapeutic Option in Colorectal Cancer

GenomeRNAi Phenotypes related to Selection of Therapeutic Option in Colorectal Cancer according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.73 BRAF KRAS
2 Decreased viability GR00106-A-0 9.73 KRAS
3 Decreased viability GR00221-A-1 9.73 KRAS
4 Decreased viability GR00221-A-2 9.73 KRAS
5 Decreased viability GR00221-A-4 9.73 BRAF
6 Decreased viability GR00301-A 9.73 BRAF KRAS
7 Decreased viability GR00381-A-1 9.73 BRAF KRAS
8 Decreased viability GR00402-S-2 9.73 BRAF KRAS
9 Reduced mammosphere formation GR00396-S 8.8 BRAF KRAS NRAS

MGI Mouse Phenotypes related to Selection of Therapeutic Option in Colorectal Cancer:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.54 BRAF KRAS NRAS
2 digestive/alimentary MP:0005381 9.5 BRAF KRAS NRAS
3 limbs/digits/tail MP:0005371 9.43 BRAF KRAS NRAS
4 liver/biliary system MP:0005370 9.33 BRAF KRAS NRAS
5 neoplasm MP:0002006 9.13 BRAF KRAS NRAS
6 pigmentation MP:0001186 8.8 BRAF KRAS NRAS

Drugs & Therapeutics for Selection of Therapeutic Option in Colorectal Cancer

Search Clinical Trials , NIH Clinical Center for Selection of Therapeutic Option in Colorectal Cancer

Genetic Tests for Selection of Therapeutic Option in Colorectal Cancer

Anatomical Context for Selection of Therapeutic Option in Colorectal Cancer

MalaCards organs/tissues related to Selection of Therapeutic Option in Colorectal Cancer:

42
Thyroid, Skin, Liver, Colon, Bone, Myeloid

Publications for Selection of Therapeutic Option in Colorectal Cancer

Variations for Selection of Therapeutic Option in Colorectal Cancer

Expression for Selection of Therapeutic Option in Colorectal Cancer

Search GEO for disease gene expression data for Selection of Therapeutic Option in Colorectal Cancer.

Pathways for Selection of Therapeutic Option in Colorectal Cancer

Pathways related to Selection of Therapeutic Option in Colorectal Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.1 BRAF KRAS NRAS
2
Show member pathways
13.06 BRAF KRAS NRAS
3
Show member pathways
12.99 BRAF KRAS NRAS
4
Show member pathways
12.92 BRAF KRAS NRAS
5
Show member pathways
12.8 BRAF KRAS NRAS
6
Show member pathways
12.78 BRAF KRAS NRAS
7
Show member pathways
12.76 BRAF KRAS NRAS
8
Show member pathways
12.68 BRAF KRAS NRAS
9
Show member pathways
12.67 BRAF KRAS NRAS
10
Show member pathways
12.67 BRAF KRAS NRAS
11
Show member pathways
12.66 BRAF KRAS NRAS
12
Show member pathways
12.65 BRAF KRAS NRAS
13
Show member pathways
12.63 BRAF KRAS NRAS
14
Show member pathways
12.63 BRAF KRAS NRAS
15 12.61 BRAF KRAS NRAS
16
Show member pathways
12.59 BRAF KRAS NRAS
17
Show member pathways
12.58 BRAF KRAS NRAS
18 12.54 BRAF KRAS NRAS
19
Show member pathways
12.54 BRAF KRAS NRAS
20
Show member pathways
12.52 BRAF KRAS NRAS
21
Show member pathways
12.51 BRAF KRAS NRAS
22
Show member pathways
12.49 BRAF KRAS NRAS
23
Show member pathways
12.47 BRAF KRAS NRAS
24
Show member pathways
12.46 BRAF KRAS NRAS
25
Show member pathways
12.44 BRAF KRAS NRAS
26 12.4 BRAF KRAS NRAS
27
Show member pathways
12.35 BRAF KRAS NRAS
28
Show member pathways
12.31 BRAF KRAS NRAS
29
Show member pathways
12.28 BRAF KRAS NRAS
30
Show member pathways
12.27 BRAF KRAS NRAS
31
Show member pathways
12.19 BRAF KRAS NRAS
32
Show member pathways
12.18 BRAF KRAS NRAS
33
Show member pathways
12.15 BRAF KRAS NRAS
34
Show member pathways
12.09 BRAF KRAS NRAS
35
Show member pathways
12.05 BRAF KRAS NRAS
36 12.04 BRAF KRAS NRAS
37
Show member pathways
12.03 KRAS NRAS
38 12.03 KRAS NRAS
39
Show member pathways
12.03 KRAS NRAS
40
Show member pathways
12.02 BRAF KRAS NRAS
41
Show member pathways
12.01 KRAS NRAS
42
Show member pathways
12.01 BRAF KRAS NRAS
43
Show member pathways
12 KRAS NRAS
44
Show member pathways
12 BRAF KRAS NRAS
45 11.99 BRAF KRAS
46 11.99 BRAF KRAS
47 11.97 KRAS NRAS
48
Show member pathways
11.97 KRAS NRAS
49
Show member pathways
11.97 BRAF KRAS NRAS
50 11.96 BRAF KRAS

GO Terms for Selection of Therapeutic Option in Colorectal Cancer

Biological processes related to Selection of Therapeutic Option in Colorectal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 9.32 BRAF KRAS
2 Ras protein signal transduction GO:0007265 9.26 KRAS NRAS
3 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.16 KRAS NRAS
4 visual learning GO:0008542 8.96 BRAF KRAS
5 MAPK cascade GO:0000165 8.8 BRAF KRAS NRAS

Molecular functions related to Selection of Therapeutic Option in Colorectal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 8.8 BRAF KRAS NRAS

Sources for Selection of Therapeutic Option in Colorectal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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