MCID: SLC040
MIFTS: 21

Selection of Therapeutic Option in Melanoma

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Selection of Therapeutic Option in Melanoma

MalaCards integrated aliases for Selection of Therapeutic Option in Melanoma:

Name: Selection of Therapeutic Option in Melanoma 58

Classifications:



External Ids:

Orphanet 58 ORPHA544260

Summaries for Selection of Therapeutic Option in Melanoma

MalaCards based summary : Selection of Therapeutic Option in Melanoma is related to selection of therapeutic option in colorectal cancer and melphalan allergy. An important gene associated with Selection of Therapeutic Option in Melanoma is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Nanog in Mammalian ESC Pluripotency. Affiliated tissues include thyroid, skin and lung, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Related Diseases for Selection of Therapeutic Option in Melanoma

Diseases related to Selection of Therapeutic Option in Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 selection of therapeutic option in colorectal cancer 10.0 NRAS BRAF
2 melphalan allergy 10.0 NRAS BRAF
3 melanoma in congenital melanocytic nevus 10.0 NRAS BRAF
4 benign struma ovarii 9.9 NRAS BRAF
5 erdheim-chester disease 9.9 NRAS BRAF
6 adrenocortical carcinoma, hereditary 9.9 NRAS BRAF
7 rasopathy 9.9 NRAS BRAF
8 thyroid tumor 9.9 NRAS BRAF
9 thyroid cancer, nonmedullary, 2 9.9 NRAS BRAF
10 langerhans cell histiocytosis 9.9 NRAS BRAF
11 histiocytosis 9.9 NRAS BRAF
12 differentiated thyroid carcinoma 9.9 NRAS BRAF
13 thyroid carcinoma 9.9 NRAS BRAF
14 cardiofaciocutaneous syndrome 1 9.9 NRAS BRAF
15 serous cystadenocarcinoma 9.8 NRAS BRAF
16 cystadenocarcinoma 9.8 NRAS BRAF
17 malignant anus melanoma 9.8 NRAS KIT
18 malignant dermis tumor 9.8 NRAS KIT
19 malignant skin fibrous histiocytoma 9.8 NRAS KIT
20 vulvar melanoma 9.8 NRAS KIT
21 skin melanoma 9.8 NRAS BRAF
22 core binding factor acute myeloid leukemia 9.8 NRAS KIT
23 conventional fibrosarcoma 9.8 NRAS KIT
24 malignant spindle cell melanoma 9.8 NRAS KIT
25 rare cancer of corpus uteri 9.8 NRAS BRAF
26 vulvar disease 9.8 NRAS KIT
27 congenital mesoblastic nephroma 9.8 NRAS KIT
28 ovarian serous cystadenocarcinoma 9.8 NRAS BRAF
29 ocular melanoma 9.7 NRAS KIT
30 mature teratoma 9.7 KIT BRAF
31 amelanotic melanoma 9.7 KIT BRAF
32 systemic mastocytosis 9.7 NRAS KIT
33 primary mediastinal b-cell lymphoma 9.7 KIT BRAF
34 glioma susceptibility 1 9.7 NRAS BRAF
35 chronic myelomonocytic leukemia 9.6 NRAS KIT
36 colorectal adenocarcinoma 9.5 KIT BRAF
37 juvenile myelomonocytic leukemia 9.5 NRAS BRAF
38 suppression of tumorigenicity 12 9.4 KIT BRAF
39 melanoma 9.4 NRAS KIT BRAF
40 nodular malignant melanoma 9.4 NRAS KIT BRAF
41 acral lentiginous melanoma 9.4 NRAS KIT BRAF
42 mucosal melanoma 9.3 NRAS KIT BRAF
43 skin squamous cell carcinoma 9.3 NRAS KIT BRAF
44 renal cell carcinoma, papillary, 1 9.3 NRAS KIT BRAF
45 melanoma, cutaneous malignant 1 9.3 NRAS KIT BRAF
46 melanoma, uveal 9.3 NRAS KIT BRAF
47 bladder urothelial carcinoma 9.3 NRAS KIT BRAF
48 leukemia 9.3 NRAS KIT BRAF
49 sarcoma 9.3 NRAS KIT BRAF
50 myeloma, multiple 9.3 NRAS KIT BRAF

Graphical network of the top 20 diseases related to Selection of Therapeutic Option in Melanoma:



Diseases related to Selection of Therapeutic Option in Melanoma

Symptoms & Phenotypes for Selection of Therapeutic Option in Melanoma

GenomeRNAi Phenotypes related to Selection of Therapeutic Option in Melanoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.35 KIT
2 Decreased substrate adherent cell growth GR00193-A-2 9.35 KIT
3 Decreased substrate adherent cell growth GR00193-A-3 9.35 BRAF
4 Decreased substrate adherent cell growth GR00193-A-4 9.35 BRAF KIT
5 Decreased viability GR00055-A-2 9.23 BRAF
6 Decreased viability GR00221-A-1 9.23 KIT
7 Decreased viability GR00221-A-4 9.23 BRAF
8 Decreased viability GR00301-A 9.23 BRAF KIT
9 Decreased viability GR00381-A-1 9.23 BRAF
10 Decreased viability GR00402-S-2 9.23 BRAF KIT

MGI Mouse Phenotypes related to Selection of Therapeutic Option in Melanoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.54 BRAF KIT NRAS
2 digestive/alimentary MP:0005381 9.5 BRAF KIT NRAS
3 limbs/digits/tail MP:0005371 9.43 BRAF KIT NRAS
4 liver/biliary system MP:0005370 9.33 BRAF KIT NRAS
5 neoplasm MP:0002006 9.13 BRAF KIT NRAS
6 pigmentation MP:0001186 8.8 BRAF KIT NRAS

Drugs & Therapeutics for Selection of Therapeutic Option in Melanoma

Search Clinical Trials , NIH Clinical Center for Selection of Therapeutic Option in Melanoma

Genetic Tests for Selection of Therapeutic Option in Melanoma

Anatomical Context for Selection of Therapeutic Option in Melanoma

MalaCards organs/tissues related to Selection of Therapeutic Option in Melanoma:

40
Thyroid, Skin, Lung, Myeloid, B Cells

Publications for Selection of Therapeutic Option in Melanoma

Variations for Selection of Therapeutic Option in Melanoma

Expression for Selection of Therapeutic Option in Melanoma

Search GEO for disease gene expression data for Selection of Therapeutic Option in Melanoma.

Pathways for Selection of Therapeutic Option in Melanoma

Pathways related to Selection of Therapeutic Option in Melanoma according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.93 NRAS KIT BRAF
2
Show member pathways
12.83 NRAS KIT BRAF
3
Show member pathways
12.64 NRAS KIT BRAF
4
Show member pathways
12.46 NRAS KIT BRAF
5
Show member pathways
12.42 NRAS KIT BRAF
6 12.38 NRAS KIT BRAF
7 12.21 NRAS KIT BRAF
8
Show member pathways
12.16 NRAS KIT BRAF
9
Show member pathways
12.08 NRAS KIT BRAF
10
Show member pathways
12 NRAS BRAF
11 11.97 NRAS BRAF
12
Show member pathways
11.96 NRAS BRAF
13
Show member pathways
11.94 NRAS BRAF
14
Show member pathways
11.91 NRAS KIT BRAF
15
Show member pathways
11.89 NRAS KIT BRAF
16
Show member pathways
11.88 NRAS BRAF
17
Show member pathways
11.86 NRAS BRAF
18
Show member pathways
11.84 NRAS BRAF
19
Show member pathways
11.81 NRAS BRAF
20
Show member pathways
11.75 NRAS BRAF
21
Show member pathways
11.74 NRAS BRAF
22 11.66 NRAS BRAF
23 11.64 NRAS BRAF
24 11.63 NRAS BRAF
25 11.61 NRAS BRAF
26 11.46 NRAS KIT
27 11.42 NRAS BRAF
28 11.39 NRAS KIT
29
Show member pathways
11.35 NRAS BRAF
30 11.3 NRAS BRAF
31 11.09 NRAS BRAF
32 10.98 NRAS BRAF
33
Show member pathways
10.72 NRAS KIT BRAF
34 10.67 NRAS BRAF

GO Terms for Selection of Therapeutic Option in Melanoma

Biological processes related to Selection of Therapeutic Option in Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.37 KIT BRAF
2 peptidyl-tyrosine phosphorylation GO:0018108 9.32 KIT BRAF
3 somatic stem cell population maintenance GO:0035019 9.26 KIT BRAF
4 visual learning GO:0008542 9.16 KIT BRAF
5 MAPK cascade GO:0000165 9.13 NRAS KIT BRAF
6 myeloid progenitor cell differentiation GO:0002318 8.62 KIT BRAF

Molecular functions related to Selection of Therapeutic Option in Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 8.96 KIT BRAF
2 nucleotide binding GO:0000166 8.8 NRAS KIT BRAF

Sources for Selection of Therapeutic Option in Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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