MCID: SLC004
MIFTS: 35

Selective Igg Deficiency Disease

Categories: Immune diseases

Aliases & Classifications for Selective Igg Deficiency Disease

MalaCards integrated aliases for Selective Igg Deficiency Disease:

Name: Selective Igg Deficiency Disease 12 15
Igg Deficiency 45 74
Selective Immunoglobulin G Subclass Deficiency 12
Selective Immunoglobulin G Deficiency 12
Immunoglobin G Subclass Deficiency 12
Selective Igg Immunodeficiency 12
Selective Deficiency of Igg 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14176
MeSH 45 D017099
ICD10 34 D80.3
UMLS 74 C0162539

Summaries for Selective Igg Deficiency Disease

MalaCards based summary : Selective Igg Deficiency Disease, also known as igg deficiency, is related to common variable immunodeficiency and herpes zoster. An important gene associated with Selective Igg Deficiency Disease is FCGRT (Fc Fragment Of IgG Receptor And Transporter), and among its related pathways/superpathways are B cell receptor signaling pathway (KEGG) and NF-kappaB Signaling. The drugs Sulfamethoxazole and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and testes, and related phenotypes are Decreased shRNA abundance and Decreased shRNA abundance

Related Diseases for Selective Igg Deficiency Disease

Diseases related to Selective Igg Deficiency Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 common variable immunodeficiency 29.3 CD19 CD79A FCGRT
2 herpes zoster 10.0
3 mediastinal cancer 10.0 CD79A NCAM1
4 pediatric lymphoma 9.9 CD79A NCAM1
5 immunoglobulin g deficiency 9.9
6 pericoronitis 9.9 CD19 NCAM1
7 rhinoscleroma 9.8 CD19 NCAM1
8 thrombocytopenia due to platelet alloimmunization 9.8 CD19 FCGRT
9 anterior scleritis 9.8 CD19 NCAM1
10 congenital hypogammaglobulinemia 9.8 CD19 CD79A
11 bladder lymphoma 9.8 CD19 CD79A
12 monoclonal gammopathy of uncertain significance 9.8 CD19 NCAM1
13 colon lymphoma 9.8 CD19 CD79A
14 systemic lupus erythematosus 9.8
15 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.8
16 lupus erythematosus 9.8
17 myotonic dystrophy 9.8
18 myotonia atrophica 9.8
19 small intestine lymphoma 9.8 CD19 CD79A
20 lymphoma, hodgkin, classic 9.7 CD19 CD79A
21 immune deficiency disease 9.7 CD19 CD79A
22 lymphoma, mucosa-associated lymphoid type 9.7 CD19 CD79A
23 ige responsiveness, atopic 9.6
24 myotonic dystrophy 1 9.6
25 down syndrome 9.6
26 extrapulmonary tuberculosis 9.6
27 colitis 9.6
28 erysipelas 9.6
29 vasculitis 9.6
30 agammaglobulinemia 9.6 CD19 CD79A
31 hematologic cancer 9.6 CD19 NCAM1
32 solitary osseous plasmacytoma 9.5 CD19 CD79A NCAM1
33 lung lymphoma 9.5 CD19 CD79A NCAM1
34 lymphatic system cancer 9.5 CD19 CD79A NCAM1
35 mature b-cell neoplasm 9.5 CD19 CD79A NCAM1
36 leukocyte disease 9.5 CD19 CD79A NCAM1
37 myeloma, multiple 9.5 CD19 CD79A NCAM1
38 lymphoma, non-hodgkin, familial 9.4 CD19 CD79A

Graphical network of the top 20 diseases related to Selective Igg Deficiency Disease:



Diseases related to Selective Igg Deficiency Disease

Symptoms & Phenotypes for Selective Igg Deficiency Disease

GenomeRNAi Phenotypes related to Selective Igg Deficiency Disease according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00251-A-1 9.4 CD19 CD79A NCAM1
2 Decreased shRNA abundance GR00251-A-2 9.4 CD19 CD79A NCAM1

Drugs & Therapeutics for Selective Igg Deficiency Disease

Drugs for Selective Igg Deficiency Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfamethoxazole Approved Phase 4 723-46-6 5329
2
leucovorin Approved Phase 4 58-05-9 143 6006
3
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
5 Immunoglobulins Phase 4,Phase 3,Phase 2,Not Applicable
6 Antibodies Phase 4,Phase 3,Phase 2,Not Applicable
7 Immunoglobulins, Intravenous Phase 4,Phase 3,Phase 2
8 gamma-Globulins Phase 4,Phase 3,Phase 2
9 Immunologic Factors Phase 4,Phase 3,Phase 2
10 Rho(D) Immune Globulin Phase 4,Phase 3,Phase 2
11 Antibiotics, Antitubercular Phase 4,Not Applicable
12 Anti-Infective Agents Phase 4,Phase 2
13 Vitamin B9 Phase 4
14 Vitamin B Complex Phase 4
15 Anti-Infective Agents, Urinary Phase 4
16 Antimalarials Phase 4
17 Antiparasitic Agents Phase 4
18 Antitubercular Agents Phase 4
19 Folate Phase 4
20 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
21 Renal Agents Phase 4
22 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable
23 Antiprotozoal Agents Phase 4
24 Immunoglobulin G Phase 3,Phase 2
25
Ustekinumab Approved, Investigational Phase 1, Phase 2 815610-63-0
26 Heptavalent Pneumococcal Conjugate Vaccine Phase 2
27 Vaccines Phase 2
28 Interleukin-12 Phase 1, Phase 2
29 Dermatologic Agents Phase 1, Phase 2
30 Immunoglobulin A Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Deficient Subclass or Anti-polysaccharide Antibody Response Completed NCT00522821 Phase 4 intravenous immunoglobulins;antibiotics
2 IVIG Treatment for Asthmatic Patients With IgG Subclass Deficiency Unknown status NCT01992328 Phase 3 Immune Globulin
3 Safety and Efficacy of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID) Completed NCT00322556 Phase 3 Immunoglobulins Intravenous (Human)
4 Efficacy and Safety of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID) Completed NCT00168025 Phase 3 Immunoglobulins Intravenous (Human)
5 Efficacy and Safety of Intravenous Immunoglobulin IVIG-F10 in Patients With Primary Immunodeficiencies (PID) Completed NCT00168012 Phase 3 Immunoglobulins Intravenous (Human)
6 Efficacy of IgIv in Patients With IgG Subclass Deficiency and Recurrent Infections Completed NCT00417573 Phase 2 IV Gamunex 10%
7 PNEUMOCELL - Conjugated Pneumococcal Vaccination in Patients With Immunoglobulin G-deficiency Completed NCT01847781 Phase 2
8 Study of Safety, Tolerability, and Efficacy of Ustekinumab for Symptomatic Gastrointestinal Inflammation Associated With Common Variable Immunodeficiency Active, not recruiting NCT02199496 Phase 1, Phase 2
9 Susceptibility to Infections in Ataxia Telangiectasia Completed NCT02345135 Not Applicable

Search NIH Clinical Center for Selective Igg Deficiency Disease

Cochrane evidence based reviews: igg deficiency

Genetic Tests for Selective Igg Deficiency Disease

Anatomical Context for Selective Igg Deficiency Disease

MalaCards organs/tissues related to Selective Igg Deficiency Disease:

42
Skin, Brain, Testes, Spinal Cord, Colon, B Cells, Small Intestine

Publications for Selective Igg Deficiency Disease

Articles related to Selective Igg Deficiency Disease:

(show all 18)
# Title Authors Year
1
Differentiation of Common Variable Immunodeficiency from Igg Deficiency. ( 30557717 )
2018
2
Transient IgG deficiency with lesions in brain and spinal cord: a mimicker of common variable immunodeficiency syndrome. ( 27848135 )
2017
3
Recurrent C. difficile in a Patient with IgG Deficiency. ( 25945268 )
2015
4
IgG deficiency and expansion of CTG repeats in myotonic dystrophy. ( 21371814 )
2011
5
Down-Syndrome associated with MBL-deficiency, IgG-deficiency, vasculitis and mutated prothrombin. ( 19399328 )
2009
6
Recurrent erysipelas in myotonic dystrophy type 1 with IgG deficiency. ( 17389801 )
2007
7
Collagenous duodeno-ileo-colitis with transient IgG deficiency preceded by Yersinia enterocolitica intestinal infection: case report and review of literature. ( 17408550 )
2007
8
Localization of extrapulmonary tuberculosis in the synovial membrane, skin, and meninges in a patient with systemic lupus erythematosus and IgG deficiency. ( 12120911 )
2002
9
Immediate hypersensitivity in adults with IgG deficiency and recurrent respiratory infections. ( 10400485 )
1999
10
Lupus vulgaris in a patient with systemic lupus erythematosus and persistent IgG deficiency. ( 9032821 )
1997
11
Airway obstruction in adults with recurrent respiratory infections and IgG deficiency. ( 8162726 )
1994
12
IgG deficiency in adults with recurrent respiratory infections. ( 8498735 )
1993
13
Selective IgG deficiency with a transcriptional disorder of the gamma switching region gene and the IL-4 gene. ( 2278996 )
1990
14
Fatal sepsis due to Branhamella catarrhalis and Hemophilus influenzae in a child with selective IgG deficiency. ( 6603206 )
1983
15
Selective IgG deficiency (a case report). ( 6790512 )
1981
16
Isolated IgG deficiency: clinical, immunologic, and pathologic investigations. ( 7381657 )
1980
17
IgG deficiency in association with placental oedema. ( 617305 )
1977
18
A screening test for IgG deficiency. ( 4633855 )
1973

Variations for Selective Igg Deficiency Disease

Expression for Selective Igg Deficiency Disease

Search GEO for disease gene expression data for Selective Igg Deficiency Disease.

Pathways for Selective Igg Deficiency Disease

GO Terms for Selective Igg Deficiency Disease

Cellular components related to Selective Igg Deficiency Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD19 CD79A NCAM1

Biological processes related to Selective Igg Deficiency Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 8.65 CD79A
2 B cell receptor signaling pathway GO:0050853 8.62 CD19 CD79A

Sources for Selective Igg Deficiency Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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