MCID: SLC004
MIFTS: 35

Selective Igg Deficiency Disease

Categories: Immune diseases

Aliases & Classifications for Selective Igg Deficiency Disease

MalaCards integrated aliases for Selective Igg Deficiency Disease:

Name: Selective Igg Deficiency Disease 12 15
Igg Deficiency 44 73
Selective Immunoglobulin G Subclass Deficiency 12
Selective Immunoglobulin G Deficiency 12
Immunoglobin G Subclass Deficiency 12
Selective Igg Immunodeficiency 12
Selective Deficiency of Igg 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14176
ICD10 33 D80.3
MeSH 44 D017099
UMLS 73 C0162539

Summaries for Selective Igg Deficiency Disease

MalaCards based summary : Selective Igg Deficiency Disease, also known as igg deficiency, is related to common variable immunodeficiency and herpes zoster. An important gene associated with Selective Igg Deficiency Disease is FCGRT (Fc Fragment Of IgG Receptor And Transporter), and among its related pathways/superpathways are B cell receptor signaling pathway (KEGG) and NF-kappaB Signaling. Affiliated tissues include skin, brain and spinal cord, and related phenotypes are Decreased shRNA abundance and Decreased shRNA abundance

Related Diseases for Selective Igg Deficiency Disease

Diseases related to Selective Igg Deficiency Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 common variable immunodeficiency 29.6 CD19 CD79A FCGRT
2 herpes zoster 10.0
3 mediastinal cancer 10.0 CD79A NCAM1
4 pediatric lymphoma 9.9 CD79A NCAM1
5 pericoronitis 9.9 CD19 NCAM1
6 rhinoscleroma 9.9 CD19 NCAM1
7 thrombocytopenia due to platelet alloimmunization 9.9 CD19 FCGRT
8 anterior scleritis 9.9 CD19 NCAM1
9 congenital hypogammaglobulinemia 9.9 CD19 CD79A
10 bladder lymphoma 9.9 CD19 CD79A
11 monoclonal gammopathy of uncertain significance 9.9 CD19 NCAM1
12 colon lymphoma 9.9 CD19 CD79A
13 immunoglobulin g deficiency 9.9
14 small intestine lymphoma 9.8 CD19 CD79A
15 lymphoma, hodgkin, classic 9.8 CD19 CD79A
16 immune deficiency disease 9.8 CD19 CD79A
17 lymphoma, mucosa-associated lymphoid type 9.8 CD19 CD79A
18 myeloma, multiple 9.8 CD19 NCAM1
19 agammaglobulinemia 9.8 CD19 CD79A
20 systemic lupus erythematosus 9.8
21 lupus erythematosus 9.8
22 myotonic dystrophy 9.8
23 myotonia atrophica 9.8
24 hematologic cancer 9.8 CD19 NCAM1
25 solitary osseous plasmacytoma 9.7 CD19 CD79A NCAM1
26 plasma cell neoplasm 9.7 CD19 CD79A NCAM1
27 lung lymphoma 9.7 CD19 CD79A NCAM1
28 lymphatic system cancer 9.7 CD19 CD79A NCAM1
29 mature b-cell neoplasm 9.7 CD19 CD79A NCAM1
30 leukocyte disease 9.7 CD19 CD79A NCAM1
31 lymphoma, non-hodgkin, familial 9.6 CD19 CD79A
32 myotonic dystrophy 1 9.6
33 down syndrome 9.6
34 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.6
35 extrapulmonary tuberculosis 9.6
36 colitis 9.6
37 erysipelas 9.6
38 vasculitis 9.6

Graphical network of the top 20 diseases related to Selective Igg Deficiency Disease:



Diseases related to Selective Igg Deficiency Disease

Symptoms & Phenotypes for Selective Igg Deficiency Disease

GenomeRNAi Phenotypes related to Selective Igg Deficiency Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00251-A-1 9.4 CD19 CD79A NCAM1
2 Decreased shRNA abundance GR00251-A-2 9.4 CD19 CD79A NCAM1

Drugs & Therapeutics for Selective Igg Deficiency Disease

Search Clinical Trials , NIH Clinical Center for Selective Igg Deficiency Disease

Cochrane evidence based reviews: igg deficiency

Genetic Tests for Selective Igg Deficiency Disease

Anatomical Context for Selective Igg Deficiency Disease

MalaCards organs/tissues related to Selective Igg Deficiency Disease:

41
Skin, Brain, Spinal Cord, Lung, Colon, B Cells, Small Intestine

Publications for Selective Igg Deficiency Disease

Articles related to Selective Igg Deficiency Disease:

(show all 18)
# Title Authors Year
1
Differentiation of Common Variable Immunodeficiency from Igg Deficiency. ( 30557717 )
2018
2
Transient IgG deficiency with lesions in brain and spinal cord: a mimicker of common variable immunodeficiency syndrome. ( 27848135 )
2016
3
Recurrent C. difficile in a Patient with IgG Deficiency. ( 25945268 )
2015
4
IgG deficiency and expansion of CTG repeats in myotonic dystrophy. ( 21371814 )
2011
5
Down-Syndrome associated with MBL-deficiency, IgG-deficiency, vasculitis and mutated prothrombin. ( 19399328 )
2009
6
Recurrent erysipelas in myotonic dystrophy type 1 with IgG deficiency. ( 17389801 )
2007
7
Collagenous duodeno-ileo-colitis with transient IgG deficiency preceded by Yersinia enterocolitica intestinal infection: case report and review of literature. ( 17408550 )
2007
8
Localization of extrapulmonary tuberculosis in the synovial membrane, skin, and meninges in a patient with systemic lupus erythematosus and IgG deficiency. ( 12120911 )
2002
9
Immediate hypersensitivity in adults with IgG deficiency and recurrent respiratory infections. ( 10400485 )
1999
10
Lupus vulgaris in a patient with systemic lupus erythematosus and persistent IgG deficiency. ( 9032821 )
1997
11
Airway obstruction in adults with recurrent respiratory infections and IgG deficiency. ( 8162726 )
1994
12
IgG deficiency in adults with recurrent respiratory infections. ( 8498735 )
1993
13
Selective IgG deficiency with a transcriptional disorder of the gamma switching region gene and the IL-4 gene. ( 2278996 )
1990
14
Fatal sepsis due to Branhamella catarrhalis and Hemophilus influenzae in a child with selective IgG deficiency. ( 6603206 )
1983
15
Selective IgG deficiency (a case report). ( 6790512 )
1981
16
Isolated IgG deficiency: clinical, immunologic, and pathologic investigations. ( 7381657 )
1980
17
IgG deficiency in association with placental oedema. ( 617305 )
1977
18
A screening test for IgG deficiency. ( 4633855 )
1973

Variations for Selective Igg Deficiency Disease

Expression for Selective Igg Deficiency Disease

Search GEO for disease gene expression data for Selective Igg Deficiency Disease.

Pathways for Selective Igg Deficiency Disease

GO Terms for Selective Igg Deficiency Disease

Cellular components related to Selective Igg Deficiency Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD19 CD79A NCAM1

Biological processes related to Selective Igg Deficiency Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 8.96 CD19 CD79A
2 B cell receptor signaling pathway GO:0050853 8.62 CD19 CD79A

Sources for Selective Igg Deficiency Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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