Selective Immunoglobulin Deficiency Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Selective Immunoglobulin Deficiency Disease

MalaCards integrated aliases for Selective Immunoglobulin Deficiency Disease:

Name: Selective Immunoglobulin Deficiency Disease ¹² ¹⁵ ⁷⁴

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6025

NCIt ⁵¹ C27870

UMLS ⁷⁴ C0543684 C1335942

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Summaries for Selective Immunoglobulin Deficiency Disease

MalaCards based summary : Selective Immunoglobulin Deficiency Disease is related to immunoglobulin a deficiency 1 and dysgammaglobulinemia. An important gene associated with Selective Immunoglobulin Deficiency Disease is SH2D1A (SH2 Domain Containing 1A). Affiliated tissues include b cells.

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Related Diseases for Selective Immunoglobulin Deficiency Disease

Diseases related to Selective Immunoglobulin Deficiency Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)

#	Related Disease	Score	Top Affiliating Genes
1	immunoglobulin a deficiency 1	31.8	CLEC16A KIRREL3 TNFRSF13B
2	dysgammaglobulinemia	30.3	AMBRA1 CLEC16A KIRREL3 MAGT1 SH2D1A TNFRSF13B
3	selective igm deficiency disease	11.2
4	selective igd deficiency disease	11.2
5	lymphoproliferative syndrome 1	10.1	ITK SH2D1A
6	lymphoproliferative syndrome	10.1	ITK SH2D1A
7	agammaglobulinemia, x-linked	10.0	ITK SH2D1A
8	b cell deficiency	10.0	SH2D1A TNFRSF13B
9	lymphoproliferative syndrome, x-linked, 2	10.0	SH2D1A STXBP2
10	lymphoproliferative syndrome, x-linked, 1	10.0	SH2D1A STXBP2
11	immune deficiency disease	9.9	SH2D1A TNFRSF13B
12	lymphatic system disease	9.8	SH2D1A STXBP2
13	common variable immunodeficiency	9.8	MSH5 SH2D1A TNFRSF13B
14	hemophagocytic lymphohistiocytosis	9.8	ITK SH2D1A STXBP2

Graphical network of the top 20 diseases related to Selective Immunoglobulin Deficiency Disease:

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Symptoms & Phenotypes for Selective Immunoglobulin Deficiency Disease

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Drugs & Therapeutics for Selective Immunoglobulin Deficiency Disease

Search Clinical Trials , NIH Clinical Center for Selective Immunoglobulin Deficiency Disease

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Genetic Tests for Selective Immunoglobulin Deficiency Disease

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Anatomical Context for Selective Immunoglobulin Deficiency Disease

MalaCards organs/tissues related to Selective Immunoglobulin Deficiency Disease:

⁴²

B Cells

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Publications for Selective Immunoglobulin Deficiency Disease

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Genes for Selective Immunoglobulin Deficiency Disease

Genes related to Selective Immunoglobulin Deficiency Disease (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SH2D1A	SH2 Domain Containing 1A	Protein Coding	17.84	DISEASES inferred ¹⁵
2	CLEC16A	C-Type Lectin Domain Containing 16A	Protein Coding	15.76	DISEASES inferred ¹⁵
3	KIRREL3	Kirre Like Nephrin Family Adhesion Molecule 3	Protein Coding	15.37	DISEASES inferred ¹⁵
4	TNFRSF13B	TNF Receptor Superfamily Member 13B	Protein Coding	15.23	DISEASES inferred ¹⁵
5	ITK	IL2 Inducible T Cell Kinase	Protein Coding	15.16	DISEASES inferred ¹⁵
6	MAGT1	Magnesium Transporter 1	Protein Coding	14.91	DISEASES inferred ¹⁵
7	STXBP2	Syntaxin Binding Protein 2	Protein Coding	14.73	DISEASES inferred ¹⁵
8	AMBRA1	Autophagy And Beclin 1 Regulator 1	Protein Coding	14.71	DISEASES inferred ¹⁵
9	MSH5	MutS Homolog 5	Protein Coding	14.67	DISEASES inferred ¹⁵

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Variations for Selective Immunoglobulin Deficiency Disease

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Expression for Selective Immunoglobulin Deficiency Disease

Search GEO for disease gene expression data for Selective Immunoglobulin Deficiency Disease.

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Pathways for Selective Immunoglobulin Deficiency Disease

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GO Terms for Selective Immunoglobulin Deficiency Disease

Cellular components related to Selective Immunoglobulin Deficiency Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	phagocytic vesicle	GO:0045335	8.62	AMBRA1 STXBP2

Biological processes related to Selective Immunoglobulin Deficiency Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to starvation	GO:0009267	9.16	AMBRA1 CLEC16A
2	cellular defense response	GO:0006968	8.96	ITK SH2D1A
3	adaptive immune response	GO:0002250	8.8	ITK SH2D1A TNFRSF13B

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Sources for Selective Immunoglobulin Deficiency Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia