MCID: SLC007
MIFTS: 21

Selective Immunoglobulin Deficiency Disease

Categories: Immune diseases

Aliases & Classifications for Selective Immunoglobulin Deficiency Disease

MalaCards integrated aliases for Selective Immunoglobulin Deficiency Disease:

Name: Selective Immunoglobulin Deficiency Disease 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6025
NCIt 50 C27870

Summaries for Selective Immunoglobulin Deficiency Disease

MalaCards based summary : Selective Immunoglobulin Deficiency Disease is related to immunoglobulin a deficiency 1 and dysgammaglobulinemia. An important gene associated with Selective Immunoglobulin Deficiency Disease is SH2D1A (SH2 Domain Containing 1A), and among its related pathways/superpathways are NF-kappaB Signaling and Primary immunodeficiency. Related phenotypes are hematopoietic system and immune system

Related Diseases for Selective Immunoglobulin Deficiency Disease

Diseases related to Selective Immunoglobulin Deficiency Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 immunoglobulin a deficiency 1 32.4 CD40LG CD79A
2 dysgammaglobulinemia 29.7 CD40LG CD79A ITK MAGT1 SH2D1A
3 selective igm deficiency disease 11.0
4 selective igg deficiency disease 10.6 CD40LG CD79A
5 c1q nephropathy 10.6 CD40LG CD79A
6 meningovascular neurosyphilis 10.6 CD40LG CD79A
7 alpha chain disease 10.6 CD40LG CD79A
8 brill-zinsser disease 10.6 CD40LG CD79A
9 exudative glomerulonephritis 10.6 CD40LG CD79A
10 cork-handlers' disease 10.6 CD40LG CD79A
11 salpingo-oophoritis 10.6 CD40LG CD79A
12 early yaws 10.6 CD40LG CD79A
13 ventilation pneumonitis 10.6 CD40LG CD79A
14 chronic interstitial cystitis 10.6 CD40LG CD79A
15 axillary adenitis 10.6 CD40LG CD79A
16 cryofibrinogenemia 10.6 CD40LG CD79A
17 trichostrongyloidiasis 10.6 CD40LG CD79A
18 subacute bacterial endocarditis 10.6 CD40LG CD79A
19 heterophyiasis 10.6 CD40LG CD79A
20 immunoglobulin g deficiency 10.6 CD40LG CD79A
21 orbital granuloma 10.6 CD40LG CD79A
22 transient hypogammaglobulinemia of infancy 10.6 CD40LG CD79A
23 hyperglobulinemic purpura 10.6 CD40LG CD79A
24 gastroduodenitis 10.6 CD40LG CD79A
25 bacterial conjunctivitis 10.6 CD40LG CD79A
26 heavy chain disease 10.6 CD40LG CD79A
27 ophthalmia neonatorum 10.6 CD40LG CD79A
28 parotid disease 10.6 CD40LG CD79A
29 cerebral arteritis 10.6 CD40LG CD79A
30 geniculate herpes zoster 10.6 CD40LG CD79A
31 erythema elevatum diutinum 10.6 CD40LG CD79A
32 sporotrichosis 10.6 CD40LG CD79A
33 fallopian tube disease 10.6 CD40LG CD79A
34 hyperimmunoglobulin syndrome 10.5 CD40LG CD79A
35 congenital syphilis 10.5 CD40LG CD79A
36 polyclonal hypergammaglobulinemia 10.5 CD40LG CD79A
37 monoclonal paraproteinemia 10.5 CD40LG CD79A
38 salpingitis 10.5 CD40LG CD79A
39 ocular toxoplasmosis 10.5 CD40LG CD79A
40 congenital hypogammaglobulinemia 10.5 CD40LG CD79A
41 acute maxillary sinusitis 10.5 CD40LG CD79A
42 chronic polyneuropathy 10.5 CD40LG CD79A
43 spinocerebellar ataxia, autosomal recessive 10 10.5 CD40LG CD79A
44 parasitic ichthyosporea infectious disease 10.5 CD40LG CD79A
45 cd40 ligand deficiency 10.5 CD40LG CD79A
46 rhinosporidiosis 10.5 CD40LG CD79A
47 secondary syphilis 10.5 CD40LG CD79A
48 yellow nail syndrome 10.5 CD40LG CD79A
49 congenital toxoplasmosis 10.5 CD40LG CD79A
50 chorioretinitis 10.5 CD40LG CD79A

Graphical network of the top 20 diseases related to Selective Immunoglobulin Deficiency Disease:



Diseases related to Selective Immunoglobulin Deficiency Disease

Symptoms & Phenotypes for Selective Immunoglobulin Deficiency Disease

MGI Mouse Phenotypes related to Selective Immunoglobulin Deficiency Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 CD40LG CD79A CORO1A ITK MAGT1 SH2D1A
2 immune system MP:0005387 9.17 CD40LG CD79A CORO1A ITK MAGT1 SH2D1A

Drugs & Therapeutics for Selective Immunoglobulin Deficiency Disease

Search Clinical Trials , NIH Clinical Center for Selective Immunoglobulin Deficiency Disease

Genetic Tests for Selective Immunoglobulin Deficiency Disease

Anatomical Context for Selective Immunoglobulin Deficiency Disease

Publications for Selective Immunoglobulin Deficiency Disease

Variations for Selective Immunoglobulin Deficiency Disease

Expression for Selective Immunoglobulin Deficiency Disease

Search GEO for disease gene expression data for Selective Immunoglobulin Deficiency Disease.

Pathways for Selective Immunoglobulin Deficiency Disease

Pathways related to Selective Immunoglobulin Deficiency Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 CD40LG CD79A ITK SH2D1A
2 10.52 CD40LG CD79A

GO Terms for Selective Immunoglobulin Deficiency Disease

Cellular components related to Selective Immunoglobulin Deficiency Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagocytic vesicle GO:0045335 8.62 CORO1A STXBP2

Biological processes related to Selective Immunoglobulin Deficiency Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 9.32 CD40LG CD79A
2 positive regulation of T cell proliferation GO:0042102 9.26 CD40LG CORO1A
3 cellular defense response GO:0006968 9.16 ITK SH2D1A
4 adaptive immune response GO:0002250 9.13 CD79A ITK SH2D1A
5 B cell proliferation GO:0042100 8.62 CD40LG CD79A

Sources for Selective Immunoglobulin Deficiency Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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