Selective Immunoglobulin Deficiency Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Selective Immunoglobulin Deficiency Disease

MalaCards integrated aliases for Selective Immunoglobulin Deficiency Disease:

Name: Selective Immunoglobulin Deficiency Disease ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6025

NCIt ⁵⁰ C27870

UMLS ⁷³ C1335942 C0543684

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Summaries for Selective Immunoglobulin Deficiency Disease

MalaCards based summary : Selective Immunoglobulin Deficiency Disease is related to immunoglobulin a deficiency 1 and dysgammaglobulinemia. An important gene associated with Selective Immunoglobulin Deficiency Disease is SH2D1A (SH2 Domain Containing 1A), and among its related pathways/superpathways are NF-kappaB Signaling and Primary immunodeficiency. Related phenotypes are hematopoietic system and immune system

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Related Diseases for Selective Immunoglobulin Deficiency Disease

Diseases related to Selective Immunoglobulin Deficiency Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)

#	Related Disease	Score	Top Affiliating Genes
1	immunoglobulin a deficiency 1	32.4	CD40LG CD79A
2	dysgammaglobulinemia	29.7	CD40LG CD79A ITK MAGT1 SH2D1A
3	selective igm deficiency disease	11.0
4	selective igg deficiency disease	10.6	CD40LG CD79A
5	c1q nephropathy	10.6	CD40LG CD79A
6	meningovascular neurosyphilis	10.6	CD40LG CD79A
7	alpha chain disease	10.6	CD40LG CD79A
8	brill-zinsser disease	10.6	CD40LG CD79A
9	exudative glomerulonephritis	10.6	CD40LG CD79A
10	cork-handlers' disease	10.6	CD40LG CD79A
11	salpingo-oophoritis	10.6	CD40LG CD79A
12	early yaws	10.6	CD40LG CD79A
13	ventilation pneumonitis	10.6	CD40LG CD79A
14	chronic interstitial cystitis	10.6	CD40LG CD79A
15	axillary adenitis	10.6	CD40LG CD79A
16	cryofibrinogenemia	10.6	CD40LG CD79A
17	trichostrongyloidiasis	10.6	CD40LG CD79A
18	subacute bacterial endocarditis	10.6	CD40LG CD79A
19	heterophyiasis	10.6	CD40LG CD79A
20	immunoglobulin g deficiency	10.6	CD40LG CD79A
21	orbital granuloma	10.6	CD40LG CD79A
22	transient hypogammaglobulinemia of infancy	10.6	CD40LG CD79A
23	hyperglobulinemic purpura	10.6	CD40LG CD79A
24	gastroduodenitis	10.6	CD40LG CD79A
25	bacterial conjunctivitis	10.6	CD40LG CD79A
26	heavy chain disease	10.6	CD40LG CD79A
27	ophthalmia neonatorum	10.6	CD40LG CD79A
28	parotid disease	10.6	CD40LG CD79A
29	cerebral arteritis	10.6	CD40LG CD79A
30	geniculate herpes zoster	10.6	CD40LG CD79A
31	erythema elevatum diutinum	10.6	CD40LG CD79A
32	sporotrichosis	10.6	CD40LG CD79A
33	fallopian tube disease	10.6	CD40LG CD79A
34	hyperimmunoglobulin syndrome	10.5	CD40LG CD79A
35	congenital syphilis	10.5	CD40LG CD79A
36	polyclonal hypergammaglobulinemia	10.5	CD40LG CD79A
37	monoclonal paraproteinemia	10.5	CD40LG CD79A
38	salpingitis	10.5	CD40LG CD79A
39	ocular toxoplasmosis	10.5	CD40LG CD79A
40	congenital hypogammaglobulinemia	10.5	CD40LG CD79A
41	acute maxillary sinusitis	10.5	CD40LG CD79A
42	chronic polyneuropathy	10.5	CD40LG CD79A
43	spinocerebellar ataxia, autosomal recessive 10	10.5	CD40LG CD79A
44	parasitic ichthyosporea infectious disease	10.5	CD40LG CD79A
45	cd40 ligand deficiency	10.5	CD40LG CD79A
46	rhinosporidiosis	10.5	CD40LG CD79A
47	secondary syphilis	10.5	CD40LG CD79A
48	yellow nail syndrome	10.5	CD40LG CD79A
49	congenital toxoplasmosis	10.5	CD40LG CD79A
50	chorioretinitis	10.5	CD40LG CD79A

Graphical network of the top 20 diseases related to Selective Immunoglobulin Deficiency Disease:

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Symptoms & Phenotypes for Selective Immunoglobulin Deficiency Disease

MGI Mouse Phenotypes related to Selective Immunoglobulin Deficiency Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.5	CD40LG CD79A CORO1A ITK MAGT1 SH2D1A
2	immune system	MP:0005387	9.17	CD40LG CD79A CORO1A ITK MAGT1 SH2D1A

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Drugs & Therapeutics for Selective Immunoglobulin Deficiency Disease

Search Clinical Trials , NIH Clinical Center for Selective Immunoglobulin Deficiency Disease

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Genetic Tests for Selective Immunoglobulin Deficiency Disease

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Anatomical Context for Selective Immunoglobulin Deficiency Disease

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Publications for Selective Immunoglobulin Deficiency Disease

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Genes for Selective Immunoglobulin Deficiency Disease

Genes related to Selective Immunoglobulin Deficiency Disease (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SH2D1A	SH2 Domain Containing 1A	Protein Coding	17.7	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	CD40LG	CD40 Ligand	Protein Coding	16.09	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	CD79A	CD79a Molecule	Protein Coding	16.07	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	MAGT1	Magnesium Transporter 1	Protein Coding	15.03	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	ITK	IL2 Inducible T Cell Kinase	Protein Coding	14.83	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	STXBP2	Syntaxin Binding Protein 2	Protein Coding	14.82	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	CORO1A	Coronin 1A	Protein Coding	14.67	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Selective Immunoglobulin Deficiency Disease

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Expression for Selective Immunoglobulin Deficiency Disease

Search GEO for disease gene expression data for Selective Immunoglobulin Deficiency Disease.

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Pathways for Selective Immunoglobulin Deficiency Disease

Pathways related to Selective Immunoglobulin Deficiency Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	NF-kappaB Signaling ⁴	11.44	CD40LG CD79A ITK SH2D1A
2	Primary immunodeficiency ³⁷	10.52	CD40LG CD79A

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GO Terms for Selective Immunoglobulin Deficiency Disease

Cellular components related to Selective Immunoglobulin Deficiency Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	phagocytic vesicle	GO:0045335	8.62	CORO1A STXBP2

Biological processes related to Selective Immunoglobulin Deficiency Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	B cell differentiation	GO:0030183	9.32	CD40LG CD79A
2	positive regulation of T cell proliferation	GO:0042102	9.26	CD40LG CORO1A
3	cellular defense response	GO:0006968	9.16	ITK SH2D1A
4	adaptive immune response	GO:0002250	9.13	CD79A ITK SH2D1A
5	B cell proliferation	GO:0042100	8.62	CD40LG CD79A

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Sources for Selective Immunoglobulin Deficiency Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

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²⁰ GeneAnalytics

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²³ GeneHancer via GeneCards

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²⁵ Genetics Home Reference

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²⁷ GEO DataSets

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⁷¹ TGDB

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⁷⁶ Wikipedia