MCID: SLL002
MIFTS: 23

Sella Turcica Neoplasm

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Sella Turcica Neoplasm

MalaCards integrated aliases for Sella Turcica Neoplasm:

Name: Sella Turcica Neoplasm 12 15 73
Tumor of Sella Turcica 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3643
NCIt 50 C4944
UMLS 73 C0748616

Summaries for Sella Turcica Neoplasm

MalaCards based summary : Sella Turcica Neoplasm, also known as tumor of sella turcica, is related to gigantism and pituitary infarct. An important gene associated with Sella Turcica Neoplasm is PRL (Prolactin), and among its related pathways/superpathways is Neuroscience. The drugs Chitosan and Anticholesteremic Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, cortex and ovary.

Related Diseases for Sella Turcica Neoplasm

Diseases related to Sella Turcica Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 gigantism 10.2 GHRH PRL
2 pituitary infarct 10.2 POMC PRL
3 chiasmal syndrome 10.2 POMC PRL
4 adenohypophysitis 10.2 POMC PRL
5 pituitary apoplexy 10.2 POMC PRL
6 pituitary carcinoma 10.2 POMC PRL
7 empty sella syndrome 10.2 POMC PRL
8 nelson syndrome 10.2 POMC PRL
9 sheehan syndrome 10.2 POMC PRL
10 acth-secreting pituitary adenoma 10.2 POMC PRL
11 intracystic papillary adenoma 10.2 PGR PRL
12 functioning pituitary adenoma 10.2 POMC PRL
13 diabetes insipidus 10.1 POMC PRL
14 diabetes insipidus, neurohypophyseal 10.1 POMC PRL
15 sex differentiation disease 10.1 POMC PRL
16 estrogen excess 10.1 PGR PRL
17 mammographic density 10.1 PGR PRL
18 hypothyroidism, congenital, nongoitrous, 4 10.1 POMC PRL
19 adrenal cortex disease 10.1 POMC PRL
20 noma 10.1 PGR POMC
21 glucocorticoid deficiency 1 10.1 MRAP POMC
22 obstructive hydrocephalus 10.1 PRL SYP
23 partial motor epilepsy 10.1 RBFOX3 SYP
24 pituitary tumors 10.1 POMC PRL
25 suprasellar meningioma 10.1 PGR POMC
26 cauda equina neoplasm 10.1 RBFOX3 SYP
27 cerebral ventricle cancer 10.1 RBFOX3 SYP
28 pituitary hormone deficiency, combined, 2 10.1 POMC PRL
29 benign ependymoma 10.1 RBFOX3 SYP
30 carcinoid syndrome 10.1 GHRH SYP
31 nodular nonsuppurative panniculitis 10.1 F8 POMC
32 childhood oligodendroglioma 10.1 RBFOX3 SYP
33 tanycytic ependymoma 10.1 RBFOX3 SYP
34 familial glucocorticoid deficiency 10.1 MRAP POMC
35 granulosa cell tumor of the ovary 10.1 PRL SYP
36 thyroid gland disease 10.1 POMC PRL
37 hypothalamic disease 10.1 GHRH POMC PRL
38 pancreatic endocrine carcinoma 10.1 POMC SYP
39 hyperpituitarism 10.1 GHRH POMC PRL
40 chromophobe adenoma 10.1 GHRH POMC PRL
41 cerebellar liponeurocytoma 10.1 RBFOX3 SYP
42 pituitary-dependent cushing's disease 10.1 GHRH POMC PRL
43 olfactory nerve neoplasm 10.1 POMC SYP
44 male reproductive organ benign neoplasm 10.1 POMC SYP
45 pituitary gland disease 10.1 GHRH POMC PRL
46 hypopituitarism 10.1 GHRH POMC PRL
47 adenomyosis 10.1 PGR PRL
48 acromegaly 10.1 GHRH POMC PRL
49 hyperprolactinemia 10.1 POMC PRL
50 olfactory groove meningioma 10.0 PGR SYP

Graphical network of the top 20 diseases related to Sella Turcica Neoplasm:



Diseases related to Sella Turcica Neoplasm

Symptoms & Phenotypes for Sella Turcica Neoplasm

Drugs & Therapeutics for Sella Turcica Neoplasm

Drugs for Sella Turcica Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chitosan Approved Not Applicable 9012-76-4 71853
2 Anticholesteremic Agents Not Applicable
3 Lipid Regulating Agents Not Applicable
4 Coagulants Not Applicable
5 Chelating Agents Not Applicable
6 Hypolipidemic Agents Not Applicable
7 Antimetabolites Not Applicable
8 Hemostatics Not Applicable
9 Fibrin Tissue Adhesive Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Chitosan Scaffold for Sellar Floor Repair in Endoscopic Endonasal Transsphenoidal Surgery Completed NCT03280849 Not Applicable
2 Clinical Study of Structural and Functional Evaluation of the Visual Pathway Not yet recruiting NCT03591315

Search NIH Clinical Center for Sella Turcica Neoplasm

Genetic Tests for Sella Turcica Neoplasm

Anatomical Context for Sella Turcica Neoplasm

MalaCards organs/tissues related to Sella Turcica Neoplasm:

41
Bone, Cortex, Ovary, Pituitary, Cervix, Thyroid, Adrenal Cortex

Publications for Sella Turcica Neoplasm

Variations for Sella Turcica Neoplasm

Expression for Sella Turcica Neoplasm

Search GEO for disease gene expression data for Sella Turcica Neoplasm.

Pathways for Sella Turcica Neoplasm

Pathways related to Sella Turcica Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 POMC RBFOX3 SYP

GO Terms for Sella Turcica Neoplasm

Cellular components related to Sella Turcica Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 F8 GHRH POMC PRL TTR
2 terminal bouton GO:0043195 8.62 GHRH SYP

Biological processes related to Sella Turcica Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.33 GHRH PGR POMC
2 mammary gland development GO:0030879 9.26 PGR PRL
3 regulation of signaling receptor activity GO:0010469 9.26 GHRH POMC PRL TTR
4 positive regulation of lactation GO:1903489 8.62 GHRH PRL

Molecular functions related to Sella Turcica Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 type 3 melanocortin receptor binding GO:0031781 9.26 MRAP POMC
2 type 4 melanocortin receptor binding GO:0031782 9.16 MRAP POMC
3 type 1 melanocortin receptor binding GO:0070996 8.96 MRAP POMC
4 hormone activity GO:0005179 8.92 GHRH POMC PRL TTR

Sources for Sella Turcica Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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