Sella Turcica Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Sella Turcica Neoplasm

MalaCards integrated aliases for Sella Turcica Neoplasm:

Name: Sella Turcica Neoplasm ¹² ¹⁵ ⁷³

Tumor of Sella Turcica ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3643

NCIt ⁵⁰ C4944

UMLS ⁷³ C0748616

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Summaries for Sella Turcica Neoplasm

MalaCards based summary : Sella Turcica Neoplasm, also known as tumor of sella turcica, is related to gigantism and pituitary infarct. An important gene associated with Sella Turcica Neoplasm is PRL (Prolactin), and among its related pathways/superpathways is Neuroscience. The drugs Chitosan and Anticholesteremic Agents have been mentioned in the context of this disorder. Affiliated tissues include bone.

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Related Diseases for Sella Turcica Neoplasm

Diseases related to Sella Turcica Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)

#	Related Disease	Score	Top Affiliating Genes
1	gigantism	10.7	GHRH PRL
2	pituitary infarct	10.6	POMC PRL
3	adenohypophysitis	10.6	POMC PRL
4	chiasmal syndrome	10.6	POMC PRL
5	pituitary apoplexy	10.6	POMC PRL
6	pituitary carcinoma	10.6	POMC PRL
7	empty sella syndrome	10.6	POMC PRL
8	nelson syndrome	10.6	POMC PRL
9	sheehan syndrome	10.6	POMC PRL
10	acth-secreting pituitary adenoma	10.5	POMC PRL
11	hypothyroidism, congenital, nongoitrous, 4	10.5	POMC PRL
12	functioning pituitary adenoma	10.5	POMC PRL
13	intracystic papillary adenoma	10.5	PGR PRL
14	diabetes insipidus, neurohypophyseal	10.5	POMC PRL
15	sex differentiation disease	10.5	POMC PRL
16	gangliocytoma	10.5	RBFOX3 SYP
17	thyroid crisis	10.5	F8 POMC
18	obstructive hydrocephalus	10.5	PRL SYP
19	cauda equina neoplasm	10.5	RBFOX3 SYP
20	mammographic density	10.5	PGR PRL
21	adrenal cortex disease	10.5	POMC PRL
22	adrenal gland disease	10.5	POMC PRL
23	cerebral ventricle cancer	10.5	RBFOX3 SYP
24	adenomyosis	10.5	PGR PRL
25	cerebrum cancer	10.5	RBFOX3 SYP
26	supratentorial cancer	10.4	RBFOX3 SYP
27	childhood oligodendroglioma	10.4	RBFOX3 SYP
28	tanycytic ependymoma	10.4	RBFOX3 SYP
29	pineal parenchymal tumor of intermediate differentiation	10.4	RBFOX3 SYP
30	granulosa cell tumor of the ovary	10.4	PRL SYP
31	cerebellar liponeurocytoma	10.4	RBFOX3 SYP
32	carcinoid syndrome	10.4	GHRH SYP
33	endocrine pancreas disease	10.4	GHRH POMC
34	pituitary tumors	10.3	POMC PRL
35	pituitary hormone deficiency, combined, 2	10.3	POMC PRL
36	nodular nonsuppurative panniculitis	10.3	F8 POMC
37	thyroid gland disease	10.3	POMC PRL
38	noma	10.3	PGR POMC
39	cervix small cell carcinoma	10.3	POMC SYP
40	pancreatic serous cystadenoma	10.3	PGR SYP
41	hyperprolactinemia	10.3	POMC PRL
42	glucocorticoid deficiency 1	10.2	MRAP POMC
43	glycogen-rich clear cell breast carcinoma	10.2	PGR SYP
44	perivascular epithelioid cell tumor	10.2	PGR SYP
45	cervical clear cell adenocarcinoma	10.2	PGR SYP
46	ectopic cushing syndrome	10.2	POMC SYP
47	spermatocele	10.2	PGR SYP
48	adrenal rest tumor	10.2	POMC SYP
49	mixed cell type cancer	10.2	PGR SYP
50	adrenal cortical adenoma	10.2	POMC SYP

Graphical network of the top 20 diseases related to Sella Turcica Neoplasm:

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Symptoms & Phenotypes for Sella Turcica Neoplasm

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Drugs & Therapeutics for Sella Turcica Neoplasm

Drugs for Sella Turcica Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Chitosan

Approved, Nutraceutical

Not Applicable

9012-76-4

71853

Synonyms:

beta-1,4-Poly-delta-glucosamine

beta-1,4-Poly-D-glucosamine

Chicol

Chitopearl 3510

Chitopearl BC 3000

Chitopearl BCW 2500

Chitopearl BCW 3000

Chitopearl BCW 3500

Chitopearl BCW 3505

Chitopearl BCW 3507

Chitosan medium molecular weight (200-800 mpa.s)

CTA 4

Deacetylchitin

Flonac C

Flonac N

Kimitsu chitosan F

Kimitsu chitosan F 2

Kimitsu chitosan H

Kimitsu chitosan L

Kimitsu chitosan m

Kytex H

Kytex m

Poliglusam

Sea cure F

Sea cure plus

YEA

2

Anticholesteremic Agents

Not Applicable

3

Antimetabolites

Not Applicable

4

Chelating Agents

Not Applicable

5

Coagulants

Not Applicable

6

Fibrin Tissue Adhesive

Not Applicable

7

Hemostatics

Not Applicable

8

Hypolipidemic Agents

Not Applicable

9

Lipid Regulating Agents

Not Applicable

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Chitosan Scaffold for Sellar Floor Repair in Endoscopic Endonasal Transsphenoidal Surgery	Completed	NCT03280849	Not Applicable

Search NIH Clinical Center for Sella Turcica Neoplasm

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Genetic Tests for Sella Turcica Neoplasm

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Anatomical Context for Sella Turcica Neoplasm

MalaCards organs/tissues related to Sella Turcica Neoplasm:

⁴¹

Bone

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Publications for Sella Turcica Neoplasm

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Genes for Sella Turcica Neoplasm

Genes related to Sella Turcica Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PRL	Prolactin	Protein Coding	14.64	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	RBFOX3	RNA Binding Fox-1 Homolog 3	Protein Coding	14.5	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	GHRH	Growth Hormone Releasing Hormone	Protein Coding	14.49	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	F8	Coagulation Factor VIII	Protein Coding	14.24	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	POMC	Proopiomelanocortin	Protein Coding	13.99	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	SYP	Synaptophysin	Protein Coding	13.84	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	MRAP	Melanocortin 2 Receptor Accessory Protein	Protein Coding	13.83	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	TTR	Transthyretin	Protein Coding	13.72	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	PGR	Progesterone Receptor	Protein Coding	13.43	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Sella Turcica Neoplasm

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Expression for Sella Turcica Neoplasm

Search GEO for disease gene expression data for Sella Turcica Neoplasm.

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Pathways for Sella Turcica Neoplasm

Pathways related to Sella Turcica Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ⁴	11.33	POMC RBFOX3 SYP

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GO Terms for Sella Turcica Neoplasm

Cellular components related to Sella Turcica Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.02	F8 GHRH POMC PRL TTR
2	terminal bouton	GO:0043195	8.96	GHRH SYP

Biological processes related to Sella Turcica Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell-cell signaling	GO:0007267	9.33	GHRH PGR POMC
2	mammary gland development	GO:0030879	8.96	PGR PRL
3	regulation of signaling receptor activity	GO:0010469	8.92	GHRH POMC PRL TTR

Molecular functions related to Sella Turcica Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	9.43	POMC PRL TTR
2	type 4 melanocortin receptor binding	GO:0031782	9.16	MRAP POMC
3	type 3 melanocortin receptor binding	GO:0031781	8.96	MRAP POMC
4	type 1 melanocortin receptor binding	GO:0070996	8.62	MRAP POMC

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Sources for Sella Turcica Neoplasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia