Sella Turcica Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Sella Turcica Neoplasm

MalaCards integrated aliases for Sella Turcica Neoplasm:

Name: Sella Turcica Neoplasm ¹² ¹⁵ ⁷³

Tumor of Sella Turcica ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3643

NCIt ⁵⁰ C4944

UMLS ⁷³ C0748616

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Summaries for Sella Turcica Neoplasm

MalaCards based summary : Sella Turcica Neoplasm, also known as tumor of sella turcica, is related to gigantism and pituitary infarct. An important gene associated with Sella Turcica Neoplasm is PRL (Prolactin), and among its related pathways/superpathways is Neuroscience. The drugs Chitosan and Anticholesteremic Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, cortex and ovary.

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Related Diseases for Sella Turcica Neoplasm

Diseases related to Sella Turcica Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)

#	Related Disease	Score	Top Affiliating Genes
1	gigantism	10.2	GHRH PRL
2	pituitary infarct	10.2	POMC PRL
3	chiasmal syndrome	10.2	POMC PRL
4	adenohypophysitis	10.2	POMC PRL
5	pituitary apoplexy	10.2	POMC PRL
6	pituitary carcinoma	10.2	POMC PRL
7	empty sella syndrome	10.2	POMC PRL
8	nelson syndrome	10.2	POMC PRL
9	sheehan syndrome	10.2	POMC PRL
10	acth-secreting pituitary adenoma	10.2	POMC PRL
11	intracystic papillary adenoma	10.2	PGR PRL
12	functioning pituitary adenoma	10.2	POMC PRL
13	diabetes insipidus	10.1	POMC PRL
14	diabetes insipidus, neurohypophyseal	10.1	POMC PRL
15	sex differentiation disease	10.1	POMC PRL
16	estrogen excess	10.1	PGR PRL
17	mammographic density	10.1	PGR PRL
18	hypothyroidism, congenital, nongoitrous, 4	10.1	POMC PRL
19	adrenal cortex disease	10.1	POMC PRL
20	noma	10.1	PGR POMC
21	glucocorticoid deficiency 1	10.1	MRAP POMC
22	obstructive hydrocephalus	10.1	PRL SYP
23	partial motor epilepsy	10.1	RBFOX3 SYP
24	pituitary tumors	10.1	POMC PRL
25	suprasellar meningioma	10.1	PGR POMC
26	cauda equina neoplasm	10.1	RBFOX3 SYP
27	cerebral ventricle cancer	10.1	RBFOX3 SYP
28	pituitary hormone deficiency, combined, 2	10.1	POMC PRL
29	benign ependymoma	10.1	RBFOX3 SYP
30	carcinoid syndrome	10.1	GHRH SYP
31	nodular nonsuppurative panniculitis	10.1	F8 POMC
32	childhood oligodendroglioma	10.1	RBFOX3 SYP
33	tanycytic ependymoma	10.1	RBFOX3 SYP
34	familial glucocorticoid deficiency	10.1	MRAP POMC
35	granulosa cell tumor of the ovary	10.1	PRL SYP
36	thyroid gland disease	10.1	POMC PRL
37	hypothalamic disease	10.1	GHRH POMC PRL
38	pancreatic endocrine carcinoma	10.1	POMC SYP
39	hyperpituitarism	10.1	GHRH POMC PRL
40	chromophobe adenoma	10.1	GHRH POMC PRL
41	cerebellar liponeurocytoma	10.1	RBFOX3 SYP
42	pituitary-dependent cushing's disease	10.1	GHRH POMC PRL
43	olfactory nerve neoplasm	10.1	POMC SYP
44	male reproductive organ benign neoplasm	10.1	POMC SYP
45	pituitary gland disease	10.1	GHRH POMC PRL
46	hypopituitarism	10.1	GHRH POMC PRL
47	adenomyosis	10.1	PGR PRL
48	acromegaly	10.1	GHRH POMC PRL
49	hyperprolactinemia	10.1	POMC PRL
50	olfactory groove meningioma	10.0	PGR SYP

Graphical network of the top 20 diseases related to Sella Turcica Neoplasm:

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Symptoms & Phenotypes for Sella Turcica Neoplasm

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Drugs & Therapeutics for Sella Turcica Neoplasm

Drugs for Sella Turcica Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Chitosan

Approved

Not Applicable

9012-76-4

71853

Synonyms:

beta-1,4-Poly-delta-glucosamine

beta-1,4-Poly-D-glucosamine

Chicol

Chitopearl 3510

Chitopearl BC 3000

Chitopearl BCW 2500

Chitopearl BCW 3000

Chitopearl BCW 3500

Chitopearl BCW 3505

Chitopearl BCW 3507

Chitosan medium molecular weight (200-800 mpa.s)

CTA 4

Deacetylchitin

Flonac C

Flonac N

Kimitsu chitosan F

Kimitsu chitosan F 2

Kimitsu chitosan H

Kimitsu chitosan L

Kimitsu chitosan m

Kytex H

Kytex m

Poliglusam

Sea cure F

Sea cure plus

YEA

2

Anticholesteremic Agents

Not Applicable

3

Lipid Regulating Agents

Not Applicable

4

Coagulants

Not Applicable

5

Chelating Agents

Not Applicable

6

Hypolipidemic Agents

Not Applicable

7

Antimetabolites

Not Applicable

8

Hemostatics

Not Applicable

9

Fibrin Tissue Adhesive

Not Applicable

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Chitosan Scaffold for Sellar Floor Repair in Endoscopic Endonasal Transsphenoidal Surgery	Completed	NCT03280849	Not Applicable
2	Clinical Study of Structural and Functional Evaluation of the Visual Pathway	Not yet recruiting	NCT03591315

Search NIH Clinical Center for Sella Turcica Neoplasm

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Genetic Tests for Sella Turcica Neoplasm

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Anatomical Context for Sella Turcica Neoplasm

MalaCards organs/tissues related to Sella Turcica Neoplasm:

⁴¹

Bone, Cortex, Ovary, Pituitary, Cervix, Thyroid, Adrenal Cortex

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Publications for Sella Turcica Neoplasm

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Genes for Sella Turcica Neoplasm

Genes related to Sella Turcica Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PRL	Prolactin	Protein Coding	14.58	DISEASES inferred ¹⁵
2	GHRH	Growth Hormone Releasing Hormone	Protein Coding	14.46	DISEASES inferred ¹⁵
3	RBFOX3	RNA Binding Fox-1 Homolog 3	Protein Coding	14.36	DISEASES inferred ¹⁵
4	F8	Coagulation Factor VIII	Protein Coding	14.18	DISEASES inferred ¹⁵
5	POMC	Proopiomelanocortin	Protein Coding	13.95	DISEASES inferred ¹⁵
6	MRAP	Melanocortin 2 Receptor Accessory Protein	Protein Coding	13.82	DISEASES inferred ¹⁵
7	SYP	Synaptophysin	Protein Coding	13.71	DISEASES inferred ¹⁵
8	TTR	Transthyretin	Protein Coding	13.65	DISEASES inferred ¹⁵
9	PGR	Progesterone Receptor	Protein Coding	13.31	DISEASES inferred ¹⁵

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Variations for Sella Turcica Neoplasm

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Expression for Sella Turcica Neoplasm

Search GEO for disease gene expression data for Sella Turcica Neoplasm.

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Pathways for Sella Turcica Neoplasm

Pathways related to Sella Turcica Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ⁴	11.33	POMC RBFOX3 SYP

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GO Terms for Sella Turcica Neoplasm

Cellular components related to Sella Turcica Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.35	F8 GHRH POMC PRL TTR
2	terminal bouton	GO:0043195	8.62	GHRH SYP

Biological processes related to Sella Turcica Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell-cell signaling	GO:0007267	9.33	GHRH PGR POMC
2	mammary gland development	GO:0030879	9.26	PGR PRL
3	regulation of signaling receptor activity	GO:0010469	9.26	GHRH POMC PRL TTR
4	positive regulation of lactation	GO:1903489	8.62	GHRH PRL

Molecular functions related to Sella Turcica Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	type 3 melanocortin receptor binding	GO:0031781	9.26	MRAP POMC
2	type 4 melanocortin receptor binding	GO:0031782	9.16	MRAP POMC
3	type 1 melanocortin receptor binding	GO:0070996	8.96	MRAP POMC
4	hormone activity	GO:0005179	8.92	GHRH POMC PRL TTR

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Sources for Sella Turcica Neoplasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

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¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

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⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia