MCID: SMN005
MIFTS: 28

Seminal Vesicle Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Seminal Vesicle Adenocarcinoma

MalaCards integrated aliases for Seminal Vesicle Adenocarcinoma:

Name: Seminal Vesicle Adenocarcinoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:14545
NCIt 50 C39906
UMLS 70 C1519233

Summaries for Seminal Vesicle Adenocarcinoma

Disease Ontology : 12 A male reproductive organ cancer that derives from epithelial cells of glandular origin.

MalaCards based summary : Seminal Vesicle Adenocarcinoma is related to clear cell adenocarcinoma and adenocarcinoma. An important gene associated with Seminal Vesicle Adenocarcinoma is KRT7 (Keratin 7), and among its related pathways/superpathways is Relaxin signaling pathway. Affiliated tissues include prostate, and related phenotypes are cardiovascular system and cellular

Related Diseases for Seminal Vesicle Adenocarcinoma

Diseases related to Seminal Vesicle Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 390)
# Related Disease Score Top Affiliating Genes
1 clear cell adenocarcinoma 30.3 PAX8 KRT7 KRT20 KLK3 AMACR
2 adenocarcinoma 29.9 KRT7 KRT20 KRAS KLK3 KIT CEACAM5
3 male urethral cancer 10.5 KLK3 AMACR
4 ovary neuroendocrine neoplasm 10.4 KRT7 CDX2
5 atrophic vulva 10.4 KRT7 KRT20
6 anal canal paget's disease 10.4 KRT7 CDX2
7 gastric signet ring cell adenocarcinoma 10.4 KRT7 CDX2
8 urethra adenocarcinoma 10.4 KLK3 AMACR
9 anal gland adenocarcinoma 10.4 KRT7 CDX2
10 anus adenocarcinoma 10.4 KRT7 CDX2
11 adenosquamous colon carcinoma 10.4 KRT7 CDX2
12 nipples, supernumerary 10.4 KRT20 GPC3
13 leukoplakia of penis 10.4 KRT7 CEACAM5
14 urethra cancer 10.4 KLK3 AMACR
15 seminal vesicle cystadenoma 10.4 KLK3 CEACAM5
16 prostate signet ring cell adenocarcinoma 10.4 KLK3 CEACAM5
17 proliferating trichilemmal cyst 10.4 KRT7 KRT18
18 malignant acrospiroma 10.4 KRT7 CEACAM5
19 eyelid carcinoma 10.4 KRT7 KRT20
20 rete testis adenoma 10.4 PAX8 CALB2
21 cutaneous mucoepidermoid carcinoma 10.4 KRT7 CEACAM5
22 external ear carcinoma 10.4 KRT7 CEACAM5
23 vulval paget's disease 10.4 KRT7 CEACAM5
24 clear cell papillary renal cell carcinoma 10.4 KRT7 AMACR
25 chromophil adenoma of the kidney 10.4 KRT7 AMACR
26 papillary transitional carcinoma 10.4 KRT7 KRT20
27 eccrine adenocarcinoma 10.4 KRT7 CEACAM5
28 supine hypotensive syndrome 10.4 KRT7 KRT20
29 inverted transitional papilloma 10.4 KRT7 GATA3
30 malignant epithelial mesothelioma 10.4 CEACAM5 CALB2
31 meibomian cyst 10.4 KRT7 KRT20
32 intrahepatic gall duct cancer 10.4 KRT7 KRT18
33 papillary squamous carcinoma 10.4 KRT7 CEACAM5
34 prostate neuroendocrine neoplasm 10.4 KRT7 KRT20 KLK3
35 lung clear cell carcinoma 10.4 KRT7 KRT18
36 jejunal cancer 10.3 KRT7 KRT20 CDX2
37 mucinous bronchioloalveolar adenocarcinoma 10.3 KRT7 KRT20 CDX2
38 jejunal adenocarcinoma 10.3 KRT7 KRT20 CDX2
39 vaginal adenoma 10.3 KRT7 KRT20 CDX2
40 vaginal benign neoplasm 10.3 KRT7 KRT20 CDX2
41 acute orbital inflammation 10.3 KRT7 KRT20
42 chronic cystitis 10.3 KRT7 KRT20 CDX2
43 bile duct mucoepidermoid carcinoma 10.3 KRT7 CEACAM5
44 anal canal carcinoma 10.3 KRT7 KRT20 CDX2
45 papillary thymic adenocarcinoma 10.3 CEACAM5 CALB2
46 urethral villous adenoma 10.3 KRT7 KRT20 CEACAM5
47 bartholin's gland carcinoma 10.3 PAX8 KRT7 CDX2
48 ureter small cell carcinoma 10.3 KRT7 GATA3
49 ampulla of vater adenocarcinoma 10.3 KRT7 KRT20 CDX2
50 pancreatic serous cystadenocarcinoma 10.3 KRT7 KRT20 CEACAM5

Graphical network of the top 20 diseases related to Seminal Vesicle Adenocarcinoma:



Diseases related to Seminal Vesicle Adenocarcinoma

Symptoms & Phenotypes for Seminal Vesicle Adenocarcinoma

MGI Mouse Phenotypes related to Seminal Vesicle Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.17 CDX2 FLNB GATA3 GPC3 GPER1 KIT
2 cellular MP:0005384 10.14 CDX2 FLNB GATA3 GPC3 INSL3 KIT
3 embryo MP:0005380 10.02 CDX2 GATA3 GPC3 KIT KRAS KRT18
4 limbs/digits/tail MP:0005371 9.92 CDX2 FLNB GPC3 GPER1 KIT KRAS
5 normal MP:0002873 9.81 CALB2 CDX2 GATA3 KIT KLK3 KRAS
6 no phenotypic analysis MP:0003012 9.8 GATA3 GPER1 KIT KRAS PAX8 PDS5B
7 reproductive system MP:0005389 9.7 AFP CDX2 GATA3 GPC3 GPER1 INSL3
8 skeleton MP:0005390 9.32 CDX2 FLNB GATA3 GPC3 GPER1 INSL3

Drugs & Therapeutics for Seminal Vesicle Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Seminal Vesicle Adenocarcinoma

Genetic Tests for Seminal Vesicle Adenocarcinoma

Anatomical Context for Seminal Vesicle Adenocarcinoma

MalaCards organs/tissues related to Seminal Vesicle Adenocarcinoma:

40
Prostate

Publications for Seminal Vesicle Adenocarcinoma

Articles related to Seminal Vesicle Adenocarcinoma:

(show all 16)
# Title Authors PMID Year
1
Primary seminal vesicle adenocarcinoma: A case report of rare entity and discussion of its differential diagnosis using immunohistochemical approach for the core biopsy specimen. 61
31961000 2020
2
Primary seminal vesicle adenocarcinoma: a lethal yet cryptic malignancy with review of literature. 61
31852695 2019
3
A 5-year follow-up of primary seminal vesicle adenocarcinoma: A case report. 61
30313047 2018
4
Experience of Treating a Young Patient With Primary Seminal Vesicle Adenocarcinoma. 61
29550197 2018
5
Metastatic primary seminal vesicle adenocarcinoma: management of a rare tumour with multiagent chemotherapy and hormonal therapy. 61
29021144 2017
6
[Clinicopathological features of primary seminal vesicle adenocarcinoma: A report of 4 cases and review of the literature]. 61
29723459 2017
7
Primary Seminal Vesicle Adenocarcinoma Presenting With Bilateral Orbital Metastasis: A Case Report. 61
27175340 2016
8
The role of imaging in the diagnosis of recurrence of primary seminal vesicle adenocarcinoma. 61
24872954 2014
9
An unusual cause of hematospermia: Primary adenocarcinoma of the seminal vesicle. 61
23283099 2012
10
Primary seminal vesicle adenocarcinoma. 61
22040796 2011
11
[Vesiculectomy with laparoscopic partial prostatectomy in the treatment of primary adenocarcinoma of the seminal vesicle with carcinomatous transformation of the ejaculatory duct]. 61
21388710 2011
12
Primary seminal vesicle adenocarcinoma presenting as isolated metastasis to penis responding to chemotherapy and hormonal therapy. 61
17445672 2007
13
Metastasizing seminal vesicle adenocarcinoma in a Wistar rat. 61
15836444 2005
14
Primary seminal vesicle carcinoma: an immunohistochemical analysis of four cases. 61
10658909 2000
15
A spontaneous seminal vesicle adenocarcinoma in an aged F344 rat. 61
9608652 1998
16
High incidence and histogenesis of seminal vesicle adenocarcinoma and lower incidence of prostate carcinomas in the Lobund-Wistar prostate cancer rat model using N-nitrosomethylurea and testosterone. 61
8885183 1996

Variations for Seminal Vesicle Adenocarcinoma

Expression for Seminal Vesicle Adenocarcinoma

Search GEO for disease gene expression data for Seminal Vesicle Adenocarcinoma.

Pathways for Seminal Vesicle Adenocarcinoma

Pathways related to Seminal Vesicle Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.62 KRT20 KRT18 KRAS INSL3 GPER1

GO Terms for Seminal Vesicle Adenocarcinoma

Biological processes related to Seminal Vesicle Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.91 WT1 KRAS KIT GPER1 GATA3
2 negative regulation of cell proliferation GO:0008285 9.88 WT1 PDS5B GPER1 GPC3 GATA3
3 mesonephros development GO:0001823 9.52 PAX8 GATA3
4 mesenchymal to epithelial transition GO:0060231 9.49 WT1 GATA3
5 cellular response to gonadotropin stimulus GO:0071371 9.46 WT1 PAX8
6 anatomical structure morphogenesis GO:0009653 9.46 PAX8 KRT18 GPC3 GATA3
7 otic vesicle development GO:0071599 9.43 PAX8 GATA3
8 branching involved in ureteric bud morphogenesis GO:0001658 9.43 WT1 PAX8 GPC3
9 metanephric S-shaped body morphogenesis GO:0072284 9.4 WT1 PAX8
10 metanephric epithelium development GO:0072207 9.37 WT1 PAX8
11 positive regulation of thyroid hormone generation GO:2000611 9.32 PAX8 GATA3
12 kidney development GO:0001822 9.26 WT1 PAX8 GPC3 GATA3
13 mast cell differentiation GO:0060374 8.62 KIT GATA3

Sources for Seminal Vesicle Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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