Seminoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SMN007 MIFTS: 47	Seminoma Categories: Cancer diseases, Reproductive diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

Sources

Aliases & Classifications for Seminoma

MalaCards integrated aliases for Seminoma:

Name: Seminoma ¹² ⁷⁶ ⁵⁵ ⁴⁴ ¹⁵ ⁷³

Seminoma, Pure ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4440

MeSH ⁴⁴ D018239

NCIt ⁵⁰ C7328 C9309

SNOMED-CT ⁶⁸ 36741007

UMLS ⁷³ C0036631

Sources

Summaries for Seminoma

Disease Ontology : ¹² A germinoma that has material basis in cells that make sperm and eggs.

MalaCards based summary : Seminoma, also known as seminoma, pure, is related to testicular seminoma and spermatocytoma. An important gene associated with Seminoma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Peptide hormone metabolism and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Granisetron and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include testis, bone and lymph node, and related phenotype is digestive/alimentary.

Wikipedia : ⁷⁶ Seminoma (also known as pure seminoma or classical seminoma) is a germ cell tumor of the testicle or,... more...

Sources

Related Diseases for Seminoma

Diseases related to Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 239)

#	Related Disease	Score	Top Affiliating Genes
1	testicular seminoma	34.0	AFP CGA CGB3 TSPY1
2	spermatocytoma	33.3	KIT MAGEA4
3	testicular germ cell tumor	33.2	AFP ALPG ALPP CGB3 FGFR3 KIT
4	extragonadal seminoma	33.2	AFP KIT POU5F1 TNFRSF8
5	embryonal carcinoma	32.2	AFP KIT POU5F1 TNFRSF8
6	nonseminomatous germ cell tumor	31.8	AFP CGB5 CGB7
7	cryptorchidism, unilateral or bilateral	30.6	ALPG CGA CGB5
8	gonadoblastoma	30.5	ALPP KIT TSPY1
9	dysgerminoma	30.1	AFP ALPP ENO2 KIT TSPY1
10	germ cell cancer	30.1	AFP ALPG ALPP CGA ESR2 KIT
11	testicular cancer	30.0	AFP ALPP CGA CGB3 CGB5 MAGEA4
12	teratoma	30.0	AFP CGA CGB3 ENO2 KIT POU5F1
13	malignant teratoma	29.9	AFP ENO2 POU5F1
14	extragonadal germ cell cancer	29.9	AFP CGB5 POU5F1
15	mature teratoma	29.7	AFP POU5F1
16	mixed germ cell tumor	29.7	AFP CGA CGB3 KIT
17	malignant sertoli cell tumor	29.5	AFP CGB5 ENO2
18	choriocarcinoma	29.5	ALPG ALPP CGA CGB3 CGB5 CGB7
19	intratubular embryonal carcinoma	29.3	AFP KIT POU5F1 TNFRSF8
20	testis seminoma	12.3
21	testicular spermatocytic seminoma	12.2
22	mediastinum seminoma	12.2
23	tubular variant testicular seminoma	12.0
24	cribriform variant testicular seminoma	12.0
25	pseudoglandular variant testicular seminoma	12.0
26	mixed germ cell cancer	11.0
27	ovarian mixed germ cell neoplasm	10.2	AFP CGA
28	germ cells tumors	10.2
29	hepatic angiomyolipoma	10.2	AFP KIT
30	polyembryoma	10.2	AFP CGA
31	testicular malignant germ cell cancer	10.2	AFP ALPP
32	tuberculous epididymitis	10.2	AFP CGB3
33	central nervous system germinoma	10.2	ALPP POU5F1
34	brain germinoma	10.2	AFP POU5F1
35	sarcoma	10.2
36	luteoma	10.2	CGA FGFR3
37	endodermal sinus tumor	10.2
38	central nervous system germ cell tumor	10.2	AFP POU5F1
39	embryonal testis carcinoma	10.2	AFP POU5F1
40	mixed germ cell-sex cord neoplasm	10.2	KIT POU5F1 TSPY1
41	mixed type thymoma	10.2	KIT PDPN
42	corpus luteum cyst	10.2	AFP CGB5
43	chromosomal triplication	10.2	AFP CGA CGB3
44	anorchia	10.2	CGA CGB5
45	epithelioid trophoblastic tumor	10.2	CGB3 INHA
46	pediatric ovarian germ cell tumor	10.2	ALPP ENO2
47	sarcomatoid renal cell carcinoma	10.2	CGB3 KIT
48	sacrococcygeal teratoma	10.2	AFP CGA CGB7
49	pediatric ovarian dysgerminoma	10.2	ALPP ENO2
50	triploidy	10.2	AFP CGA CGB7

Graphical network of the top 20 diseases related to Seminoma:

Sources

Symptoms & Phenotypes for Seminoma

MGI Mouse Phenotypes related to Seminoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.17	ESR2 FGFR3 INHA KIT MMP16 PDPN

Sources

Drugs & Therapeutics for Seminoma

Drugs for Seminoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 136)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Granisetron

Approved, Investigational

Phase 3

109889-09-0

3510

Paclitaxel

Approved, Vet_approved

Phase 2, Phase 3,Phase 3,Phase 1

33069-62-4

36314

Lenograstim

Approved, Investigational

Phase 2, Phase 3,Phase 3,Phase 1

135968-09-1

Bleomycin

Approved, Investigational

Phase 2, Phase 3,Phase 3

11056-06-7

5360373

Etoposide

Approved

Phase 2, Phase 3,Phase 3

33419-42-0

36462

Cisplatin

Approved

Phase 2, Phase 3,Phase 3,Phase 1

15663-27-1

2767 441203 84093

Carboplatin

Approved

Phase 3,Phase 2,Phase 1

41575-94-4

10339178 38904 498142

Mechlorethamine

Approved, Investigational

Phase 3,Phase 1,Phase 2

51-75-2

4033

Ifosfamide

Approved

Phase 3,Phase 1,Phase 2

3778-73-2

3690

Dexamethasone

Approved, Investigational, Vet_approved

Phase 3,Phase 1,Phase 2

50-02-2

5743

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 3,Phase 1,Phase 2

1177-87-3

Mesna

Approved, Investigational

Phase 3,Phase 1,Phase 2

3375-50-6

598

Cyclophosphamide

Approved, Investigational

Phase 3

6055-19-2, 50-18-0

2907

Captopril

Approved

Phase 3

62571-86-2

44093

Ribavirin

Approved

Phase 3

36791-04-5

37542

Palivizumab

Approved, Investigational

Phase 3

188039-54-5

Miconazole

Approved, Investigational, Vet_approved

Phase 3

22916-47-8

4189

Fluconazole

Approved, Investigational

Phase 3

86386-73-4

3365

Itraconazole

Approved, Investigational

Phase 3

84625-61-6

55283

Caspofungin

Approved

Phase 3

179463-17-3, 162808-62-0

468682 2826718

Amphotericin B

Approved, Investigational

Phase 3

1397-89-3

5280965 14956

Ondansetron

Approved

Phase 3

99614-02-5

4595

Promethazine

Approved, Investigational

Phase 3

60-87-7

4927

Diphenhydramine

Approved, Investigational

Phase 3

147-24-0, 58-73-1

3100

Vinblastine

Approved

Phase 3

865-21-4

241903 13342

Autonomic Agents

Phase 3,Phase 2

Antiemetics

Phase 3,Phase 2

Neurotransmitter Agents

Phase 3

Serotonin Antagonists

Phase 3

Serotonin Agents

Phase 3

Gastrointestinal Agents

Phase 3,Phase 2

Peripheral Nervous System Agents

Phase 3,Phase 2

Albumin-Bound Paclitaxel

Phase 2, Phase 3,Phase 3,Phase 1

Etoposide phosphate

Phase 2, Phase 3,Phase 3

Antineoplastic Agents, Phytogenic

Phase 2, Phase 3,Phase 3,Phase 1

Antibiotics, Antitubercular

Phase 2, Phase 3,Phase 3

Topoisomerase Inhibitors

Phase 2, Phase 3,Phase 3

Antimitotic Agents

Phase 2, Phase 3,Phase 3,Phase 1

Anti-Bacterial Agents

Phase 2, Phase 3,Phase 3

Antineoplastic Agents, Alkylating

Phase 3,Phase 1,Phase 2

Immunologic Factors

Phase 3,Phase 1,Phase 2

Immunosuppressive Agents

Phase 3,Phase 1,Phase 2

Alkylating Agents

Phase 3,Phase 1,Phase 2

Antimetabolites

Phase 3,Phase 1,Phase 2

Anti-Infective Agents

Phase 3,Phase 1,Phase 2

Antiviral Agents

Phase 3,Phase 1,Phase 2

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 3,Phase 2,Phase 1

Hormones

Phase 3,Phase 2,Phase 1

Hormone Antagonists

Phase 3,Phase 2,Phase 1

Isophosphamide mustard

Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 56)

#	Name	Status	NCT ID	Phase	Drugs
1	Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle	Unknown status	NCT00589537	Phase 3
2	Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma	Unknown status	NCT00004219	Phase 3	granisetron hydrochloride;lerisetron
3	Combination Chemotherapy in Treating Men With Germ Cell Cancer	Unknown status	NCT00003643	Phase 2, Phase 3	cisplatin;etoposide;paclitaxel
4	Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer	Completed	NCT00003014	Phase 3	carboplatin
5	Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors	Completed	NCT00002596	Phase 3	carboplatin;cisplatin;cyclophosphamide;etoposide
6	Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation	Completed	NCT00004230	Phase 3	captopril;cyclophosphamide
7	Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation	Completed	NCT00014391	Phase 3	ribavirin
8	Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation	Completed	NCT00003883	Phase 3	fluconazole;itraconazole
9	Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment	Completed	NCT00008359	Phase 3	caspofungin acetate;liposomal amphotericin B
10	Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer	Completed	NCT00003941	Phase 3	cisplatin;etoposide;ifosfamide
11	Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients	Completed	NCT00003938	Phase 3	liposomal amphotericin B
12	Ondansetron With or Without Dexamethasone to Prevent Vomiting in Patients Receiving Radiation Therapy to the Upper Abdomen	Completed	NCT00016380	Phase 3	dexamethasone;ondansetron
13	Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer	Recruiting	NCT02341989	Phase 3	Bleomycin Etoposide and Cisplatin;Carboplatin
14	Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors	Recruiting	NCT02375204	Phase 3	paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
15	Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors	Terminated	NCT00072215	Phase 3	cisplatin;ifosfamide;paclitaxel;vinblastine
16	Proton Radiotherapy for Stage I, IIA, and IIB Seminoma	Unknown status	NCT01557790	Phase 2
17	Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors	Unknown status	NCT00551122	Phase 1, Phase 2	cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
18	High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy	Unknown status	NCT01172912	Phase 2	carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
19	Carboplatin AUC-10 With Early PET Scanning in Metastatic Seminoma	Completed	NCT02272816	Phase 2	Carboplatin AUC-10
20	ARQ 197 for Subjects With Relapsed or Refractory Germ Cell Tumors	Completed	NCT01055067	Phase 2	Tivantinib (ARQ 197)
21	Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors	Completed	NCT00957905	Phase 2	Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
22	Docetaxel in Treating Patients With Recurrent or Refractory Germ Cell Cancer	Completed	NCT00002903	Phase 2	docetaxel
23	Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer	Completed	NCT00002931	Phase 2	carboplatin;etoposide;ifosfamide;paclitaxel
24	Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors	Completed	NCT00453232	Phase 2	cisplatin;etoposide
25	Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment	Completed	NCT00453310	Phase 2	sunitinib malate
26	Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors	Completed	NCT00470366	Phase 2	cisplatin;ifosfamide;paclitaxel
27	Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors	Completed	NCT00070096	Phase 2	ixabepilone
28	Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation	Completed	NCT00002673	Phase 2
29	Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation	Completed	NCT00003887	Phase 2
30	Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon	Completed	NCT00010283	Phase 1, Phase 2	beclomethasone dipropionate
31	Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors	Completed	NCT00004157	Phase 2
32	Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer	Completed	NCT00003408	Phase 2
33	Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin	Completed	NCT00423852	Phase 1, Phase 2	carboplatin;ifosfamide;paclitaxel
34	Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases	Completed	NCT00154388	Phase 2	Imatinib mesylate
35	Therapeutic Strategy Guided by PET-TDM for Patients With Seminoma	Recruiting	NCT01887340	Phase 2	Carboplatin;Etoposide;Cisplatin
36	Nivolumab and Ipilimumab in Treating Patients With Rare Tumors	Recruiting	NCT02834013	Phase 2
37	Evaluating Immune Therapy, Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors	Recruiting	NCT03158064	Phase 2	Durvalumab;Tremelimumab
38	PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER	Recruiting	NCT01037790	Phase 2	PD-0332991
39	Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors	Recruiting	NCT00432094	Phase 2	carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
40	Therapy De-escalation in Seminoma Stage IIA/B	Active, not recruiting	NCT01593241	Phase 2	Carboplatin
41	Imatinib Mesylate in Treating Patients With Progressive, Refractory, or Recurrent Stage II or Stage III Testicular or Ovarian Cancer	Terminated	NCT00042952	Phase 2	imatinib mesylate
42	Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors	Terminated	NCT01808534	Phase 2	palifosfamide
43	Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer	Completed	NCT00060372	Phase 1	ipilimumab;therapeutic allogeneic lymphocytes
44	Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors	Completed	NCT00003107	Phase 1
45	Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors	Completed	NCT00313599	Phase 1	lapatinib;paclitaxel
46	Analysis of Transposon Control Pathways in Germinal Cancers of the Testicle	Unknown status	NCT02873793
47	REtrospective Study of TESTIcular CAncer Patients at the University Magdeburg	Completed	NCT02092740
48	Cardiac Function and Cardiovascular Risk Profile in Testicular Cancer Patients	Completed	NCT00705094
49	DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings	Completed	NCT01434355
50	Positron Emission Tomography in Detecting Testicle Cancer	Completed	NCT00045045	Not Applicable

Search NIH Clinical Center for Seminoma

Cochrane evidence based reviews: seminoma

Sources

Genetic Tests for Seminoma

Sources

Anatomical Context for Seminoma

MalaCards organs/tissues related to Seminoma:

⁴¹

Testis, Bone, Lymph Node, Bone Marrow, Prostate, Kidney, Liver

Sources

Publications for Seminoma

Articles related to Seminoma:

(show top 50) (show all 1334)

#	Title	Authors	Year
1	Clinical Stage IIA-IIC Seminoma: Radiation Therapy versus Systemic Chemotherapy versus Retroperitoneal Lymph Node Dissection. ( 29763926 )	von Amsberg G....Papachristofilou A.	2018
2	Retroperitoneal seminoma, a rare cause of testicular pain. ( 29903776 )	Joshi S....Sivarajah V.	2018
3	Nodular Hepatic Tuberculosis Masquerading as a Seminoma Liver Metastasis. ( 29693409 )	Harbi H....Mzali R.	2018
4	Superior vena cava obstruction by metastatic mediastinal testicular seminoma. Imaging of collateral pathways during gastrointestinal bleeding scintigraphy with <sup>99m</sup>Tc labeled red blood cells. ( 29636233 )	Valotassiou V....Georgoulias P.	2018
5	Expression of terminal deoxynucleotidyl transferase (TdT) in classical seminoma: a potential diagnostic pitfall. ( 29455318 )	Brobeil A....GattenlAPhner S.	2018
6	Granulomatous reaction of primary mediastinal seminoma leading to diagnostic delay: a case report. ( 29607195 )	Lee H....Shin K.M.	2018
7	Large intra-abdominal seminoma in a left undescended testicle complicated by torsion. ( 29599382 )	Rourke E....Kaushik D.	2018
8	Carboplatin dose based on actual renal function: no excess of acute haematotoxicity in adjuvant treatment in seminoma stage I. ( 29531843 )	Fehr M....Cathomas R.	2018
9	Controversies in the Management of Clinical Stage I Seminoma: Carboplatin a Decade in-Time to Start Backing Out. ( 29389229 )	van de Wetering R.A.W....de Wit R.	2018
10	Bilateral synchronous testicular seminoma: A rare presentation of a rare disease. ( 29633802 )	De Oliveira P.S....Lopes T.	2018
11	Current Practice Patterns Surrounding Fertility Concerns in Stage I Seminoma Patients: Survey of United States Radiation Oncologists. ( 29336660 )	Post C.M....Mitin T.	2018
12	Peritoneal Myeloid Sarcoma in a Patient Treated for a Testicular Seminoma. ( 29955031 )	Longo R....Campitiello M.	2018
13	Synchronous Leydig Cell Tumor and Seminoma in the Ipsilateral Testis. ( 29670803 )	Obiorah I.E....Ozdemirli M.	2018
14	Testicular orphan receptor 4 promotes tumor progression and implies poor survival through AKT3 regulation in seminoma. ( 29197138 )	Chen Y....Li G.	2018
15	Metastatic &quot;Burned Out&quot; Seminoma Causing Neurological Paraneoplastic Syndrome-Not Quite &quot;Burned Out&quot;. ( 29441039 )	Freifeld Y....Bagrodia A.	2018
16	Prognostic markers in clinical stage I seminoma and nonseminomatous germ cell tumours. ( 29979237 )	Pedraza A.M....Stephenson A.J.	2018
17	Seminoma Metastatic to the Orbit. ( 29334543 )		2018
18	Distinct telomere length and molecular signatures in seminoma and non-seminoma of testicular germ cell tumor. ( 29579225 )		2018
19	Paratesticular seminoma: echographic features and histological diagnosis with review of the literature. ( 29411910 )		2018
20	Testicular seminoma: Scattered radiation dose to the contralateral testis in the modern era. ( 29306641 )		2018
21	On thin ice: barriers to adoption of surveillance for patients with stage I testicular seminoma. Survey of US radiation oncologists. ( 29522295 )		2018
22	Foreign-body granuloma mimicking post-chemotherapy residual seminoma: A case of true-negative findings using diffusion-weighted whole-body magnetic resonance imaging with background suppression. ( 29719857 )		2018
23	A Risk-Adapted Approach to Patients with Stage I Seminoma according to the Status of Rete Testis: The Fourth Spanish Germ Cell Cancer Group Study. ( 29587278 )		2018
24	Retroperitoneal Lymph Node Dissection as Primary Treatment for Metastatic Seminoma. ( 29487620 )		2018
25	Prognostic factors for relapse in stage I testicular seminoma: tumor size and rete testis invasion revisited. ( 29744734 )		2018
26	Spontaneous rupture of seminoma in undescended testis with hemoperitoneum: a rare presentation. ( 29674406 )		2018
27	Retroperitoneal extragonadal seminoma developed with acute lower inferior vena cava syndrome: A case report. ( 30069432 )	Murata M...Tomita Y	2018
28	Laparoscopic Management of Chylous Leakage Using a Direct Lymph Node Injection with Methylene Blue as a Leakage Point Location Strategy in a Patient with Retroperitoneal Extragonadal Seminoma. ( 30263965 )	Subiela JD...Rosales Bordes A	2018
29	Questioning the Value of Fluorodeoxyglucose Positron Emission Tomography for Residual Lesions After Chemotherapy for Metastatic Seminoma: Results of an International Global Germ Cell Cancer Group Registry. ( 30285559 )	Cathomas R...Beyer J	2018
30	Malignant Sertoli cell tumor of the testis masquerading as seminoma with bone metastasis. ( 30303161 )	Agrawal CR...Poonia DR	2018
31	Seminoma with Neoplastic Meningitis Treated with Craniospinal Irradiation. ( 30012875 )	Sinicrope KD...Brastianos PK	2018
32	Controversies in the management of stage I seminoma: adjuvant carboplatin revisited. ( 29992462 )	Aparicio J...Spanish Germ Cell Cancer Group	2018
33	Incomplete methylation of a germ cell tumor (Seminoma) in a Prader-Willi male. ( 30003711 )	Eldar-Geva T...Eiges R	2018
34	Spermatocytic seminoma with rhabdomyoblastic differentiation: Case report and review of literature. ( 30004076 )	Pandey V...Khare MS	2018
35	Surgical resection of a giant polycystic seminoma of the mediastinum. ( 30069400 )	Goto T...Tsuchida M	2018
36	A case of spermatocytic seminoma in young individual. ( 30093773 )	Jha RK...Saidha NK	2018
37	Metachronous Testicular Seminoma After Testicular Tumor. ( 30145557 )	?uni X...Kurshumliu F	2018
38	Primary mediastinal seminoma. ( 30174881 )	Napieralska A...Miszczyk L	2018
39	Thoracoscopic resection of a cystic seminoma of the mediastinum. ( 30187669 )	Hamanaka K...Nakamura T	2018
40	SPIN1 is a proto-oncogene and SPIN3 is a tumor suppressor in human seminoma. ( 30197756 )	Janecki DM...Jaruzelska J	2018
41	Bilateral Malignant Seminoma With Ventricular Metastasis in a Bald Eagle ( Haliaeetus leucocephalus). ( 30204011 )	Sullivan PJ...BVSc ACC	2018
42	Seminoma component of mixed testicular germ cell tumor shows a higher incidence of loss of heterozygosity than pure-type seminoma. ( 30266250 )	Miyai K...Tsuda H	2018
43	Ultrasonographic features of testicular metastasis from renal clear cell carcinoma that mimics a seminoma: A case report. ( 30290683 )	Huang H...Luo Y	2018
44	Sperm imprinting integrity in seminoma patients? ( 30340650 )	Bruno C...Fauque P	2018
45	Exploring the spectrum of late effects following radical orchidectomy for stage I testicular seminoma: a systematic review of the literature. ( 30350189 )	Soon JA...Pezaro C	2018
46	Testicular seminoma in the aged rat visualized by phase-contrast X-ray computed tomography. ( 30377541 )	Thet-Thet-Lwin...Takeda T	2018
47	Long non-coding RNA H19 promotes TDRG1 expression and cisplatin resistance by sequestering miRNA-106b-5p in seminoma. ( 30430771 )	Wei J...Yang J	2018
48	Mediastinal seminoma presenting as a neck mass falsely diagnosed as anaplastic thyroid carcinoma: A case report. ( 30468316 )	Murshed K...Akhtar M	2018
49	CSE1L participates in regulating cell mitosis in human seminoma. ( 30485574 )	Liu C...Xiong C	2018
50	Mediastinal seminoma associated with multilocular thymic cyst. ( 28054283 )	Inui M....Nakajima J.	2017

Sources

Genes for Seminoma

Genes related to Seminoma (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	KIT	KIT Proto-Oncogene Receptor Tyrosine Kinase	Protein Coding	42.66	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications (show sections)	17768701 14695343 8551387 (more) 18045648 7514077 16166280 16741525 17595797 16918976 15822404 19255517 17573850 11927966 16397263 16188233 10362788 12752264 15902997 8609154 11896121 15542802 19461507 20410807 12379771 19226408 17943970 7529338 18486988 16056250 16767900 17976614 15471556 10824925 15316315 18223323 20384797 18050305 12893208 19683721 12824871 16082245
2	AFP	Alpha Fetoprotein	Protein Coding	33.82	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	10386812 9769381 19493258 (more) 15828957 18472076 1378875 7509106 15242364 17259159 9474168 9258097 8653285 18697473 1723408 7525293 19461507 2158684 9805244 15272600
3	ALPP	Alkaline Phosphatase, Placental	Protein Coding	32.93	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	2273701 8653285 1646453 (more) 17629966 2311254 9491665 18045648 2148879 9112568 1310437 10359511 9879816 7490882 1716953 7509106 2248772 7602766 10204106 19683721 8688967 20410807 9670832 8791060 7569686 1723958 16505287 9823315 8691601 7508884 16372914 10743701 15132850 1949390 1874301 1868303 2076869 18050305 1302092 12657943 11825120 19255517 7524297 8912826
4	TSPY1	Testis Specific Protein Y-Linked 1	Protein Coding	30.48	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
5	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	29.93	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Variants (show sections)
6	CGB3	Chorionic Gonadotropin Subunit Beta 3	Protein Coding	29.66	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	1372658 8394368 1711586 (more) 16033057 7509106 17025215 11489712 12910930
7	POU5F1	POU Class 5 Homeobox 1	Protein Coding	29.63	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	15725806 17682839 17117392
8	RAD17	RAD17 Checkpoint Clamp Loader Component	Protein Coding	28.66	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Functions (show sections)
9	MAGEA4	MAGE Family Member A4	Protein Coding	27.55	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11753951 12605640 17993720
10	ENO2	Enolase 2	Protein Coding	26.51	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	2204171 12852696 1645819 (more) 1739633 8392765 1947758 8683382
11	INHA	Inhibin Subunit Alpha	Protein Coding	26.15	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19255517 9365168 15056223 (more) 19661148
12	ALPG	Alkaline Phosphatase, Germ Cell	Protein Coding	25.31	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	1310437 2187297 16115909 (more) 16723857 10547581 9657344 15316315 7569686 18045648 2311254 15132850 1949390 8386657 7543237
13	DAZL	Deleted In Azoospermia Like	Protein Coding	24.31	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11956819 16228988
14	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	24.27	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	18971108 9311009 10559615 (more) 9610904 18578862 1892008 1739633 1689221 15272600 9805244 9258097 9187899
15	ESR2	Estrogen Receptor 2	Protein Coding	24.05	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	16087732 14644130 19493328
16	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	19.94	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	8912826 16200333 15644135 (more) 11838744 8200647 9670832
17	PDPN	Podoplanin	Protein Coding	18.93	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	17951198 19483629 16670463 (more) 16718353 16736189
18	CGB7	Chorionic Gonadotropin Subunit Beta 7	Protein Coding	17.23	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11005453 18578862 1716953 (more) 8653285
19	MMP16	Matrix Metallopeptidase 16	Protein Coding	15.4	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11215209
20	CGB5	Chorionic Gonadotropin Subunit Beta 5	Protein Coding	13.87	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	10843453 1694252 18068467 (more) 18787014 7690985 1378875 18697473 17025215

Sources

Variations for Seminoma

Copy number variations for Seminoma from CNVD:

⁷ (show all 13)

#	CNVD ID	Chromosom	Start	End	Type	CNVD Disease
1	55928	11	56400000	134452384	Loss	Seminomas
2	61576	12	1	56300000	Gain	Seminomas
3	119165	18	1	15400000	Loss	Seminomas
4	120979	18	35500000	76117153	Loss	Seminomas
5	138723	2	169500000	182700000	Gain	Seminomas
6	146936	2	56300000	182700000	Loss	Seminomas
7	157118	21	12300000	46944323	Gain	Seminomas
8	160299	22	11800000	49691432	Loss	Seminomas
9	217037	7	1	158821424	Gain	Seminomas
10	237233	8	2200000	146274826	Gain	Seminomas
11	257126	X	1	24900000	Gain	Seminomas
12	262546	X	37500000	154913754	Gain	Seminomas
13	262571	X	37500000	47300000	Gain	Seminomas

Sources

Expression for Seminoma

Search GEO for disease gene expression data for Seminoma.

Sources

Pathways for Seminoma

Pathways related to Seminoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Peptide hormone metabolism ⁶⁶ Show member pathways Glycoprotein hormones ⁶⁶ Insulin processing ⁶⁶ Metabolism of Angiotensinogen to Angiotensins ⁶⁶ Peptide hormone biosynthesis ⁶⁶ Synthesis, secretion, and deacylation of Ghrelin ⁶⁶	11.72	CGA CGB3 CGB5 INHA
2	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors ⁶⁶ Show member pathways Activation of the TFAP2 (AP-2) family of transcription factors ⁶⁶ Negative regulation of activity of TFAP2 (AP-2) family transcription factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of cell cycle factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ⁶⁶ TFAP2 (AP-2) family regulates transcription of other transcription factors ⁶⁶ TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation ⁶⁶	10.89	CGA CGB3 CGB5 KIT
3	Ovarian Infertility Genes ¹	10.64	DAZL ESR2 INHA
4	Thiamine metabolism ³⁷	10.46	ALPG ALPP

Sources

GO Terms for Seminoma

Cellular components related to Seminoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.56	AFP CGA CGB3 CGB5 CGB7 ENO2
2	extracellular region	GO:0005576	9.32	AFP ALPG CGA CGB3 CGB5 CGB7

Biological processes related to Seminoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of signaling receptor activity	GO:0010469	9.72	CGA CGB3 CGB5 CGB7 INHA
2	hormone-mediated signaling pathway	GO:0009755	9.43	CGB3 CGB5 CGB7
3	chondrocyte proliferation	GO:0035988	9.37	FGFR3 MMP16
4	peptide hormone processing	GO:0016486	9.33	CGA CGB3 CGB5
5	female gamete generation	GO:0007292	9.13	CGB3 CGB5 CGB7
6	cell-cell signaling	GO:0007267	9.1	CGB3 CGB5 CGB7 ESR2 FGFR3 INHA

Molecular functions related to Seminoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	alkaline phosphatase activity	GO:0004035	8.96	ALPG ALPP
2	hormone activity	GO:0005179	8.92	CGA CGB3 CGB7 INHA

Sources

Sources for Seminoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia