Seminoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SMN007 MIFTS: 42	Seminoma Categories: Cancer diseases, Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Seminoma

MalaCards integrated aliases for Seminoma:

Name: Seminoma ¹¹ ⁷⁵ ⁵³ ⁴³ ¹⁴ ⁷¹

Seminoma, Pure ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:4440

MeSH ⁴³ D018239

NCIt ⁴⁹ C9309

SNOMED-CT ⁶⁸ 443675005

UMLS ⁷¹ C0036631

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Summaries for Seminoma

Disease Ontology: ¹¹ A germinoma that has material basis in cells that make sperm and eggs.

MalaCards based summary: Seminoma, also known as seminoma, pure, is related to testicular seminoma and extragonadal seminoma. An important gene associated with Seminoma is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Granisetron and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include testis, lymph node and testes, and related phenotypes are endocrine/exocrine gland and reproductive system

Wikipedia: ⁷⁵ A seminoma is a germ cell tumor of the testicle or, more rarely, the mediastinum or other extra-gonadal... more...

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Related Diseases for Seminoma

Diseases related to Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 654)

#	Related Disease	Score	Top Affiliating Genes
1	testicular seminoma	33.0	TSPY1 KIT
2	extragonadal seminoma	32.6	KIT AFP
3	mediastinum seminoma	32.5	KIT AFP
4	spermatocytoma	32.5	SSX2 POU5F1 MAGEA4 KIT AFP
5	mixed germ cell cancer	31.7	TNFRSF8 POU5F1 KIT ENO2 AFP
6	germ cell cancer	31.7	TNFRSF8 POU5F1 KIT ESR2 ENO2 ALPP
7	cryptorchidism, unilateral or bilateral	31.1	POU5F1 KIT ESR2 DAZL CGB5 ALPP
8	teratoma	31.0	POU5F1 KIT ENO2 CGB7 CGB5 CGB3
9	embryonal carcinoma	31.0	TNFRSF8 POU5F1 KIT CGB5 CGB3 ALPG
10	testicular germ cell cancer	30.9	POU5F1 MAGEA4 KIT ESR2 DAZL AFP
11	mediastinal cancer	30.8	TNFRSF8 KIT ENO2 AFP
12	turner syndrome	30.8	TSPY1 POU5F1 CGB3
13	testicular cancer	30.8	TSPY1 TNFRSF8 SSX2 POU5F1 MAGEA4 KIT
14	extragonadal germ cell cancer	30.7	CGB5 AFP
15	down syndrome	30.7	INHA CGB7 CGB5 CGB3 AFP
16	choriocarcinoma	30.7	INHA CGB7 CGB5 CGB3 ALPP ALPG
17	dysgerminoma	30.6	KIT INHA ENO2 ALPP ALPG AFP
18	gynecomastia	30.6	INHA ESR2 CGB5
19	sertoli cell tumor	30.6	INHA ENO2 CGB3 AFP
20	leydig cell tumor	30.5	KIT INHA AFP
21	gonadal dysgenesis	30.5	POU5F1 KIT CGB5 CGB3
22	malignant teratoma	30.5	TNFRSF8 POU5F1 KIT ENO2 AFP
23	mature teratoma	30.5	TNFRSF8 POU5F1 KIT ENO2 AFP
24	brain germinoma	30.4	POU5F1 KIT AFP
25	gonadoblastoma	30.4	TSPY1 POU5F1 KIT CGB5 CGB3 ALPP
26	endodermal sinus tumor	30.4	TNFRSF8 POU5F1 KIT INHA CGB5 CGB3
27	intermediate malignant teratoma	30.4	TNFRSF8 AFP
28	germinoma	30.4	POU5F1 PDPN KIT INHA CGB7 CGB5
29	male infertility	30.2	TSPY1 KIT INHA ESR2 DAZL
30	embryonal testis carcinoma	30.2	TNFRSF8 DAZL AFP
31	cystic teratoma	30.2	ENO2 AFP
32	hepatic tuberculosis	30.1	ALPP AFP
33	jejunal neoplasm	30.1	KIT ENO2
34	mixed cell type cancer	30.0	KIT ENO2 AFP
35	epididymo-orchitis	30.0	DAZL AFP
36	neuroendocrine carcinoma	29.9	KIT ENO2 AFP
37	intratubular embryonal carcinoma	29.9	TNFRSF8 POU5F1 KIT AFP
38	dysgerminoma of ovary	29.9	TNFRSF8 POU5F1 KIT AFP
39	mast-cell sarcoma	29.9	TNFRSF8 KIT
40	pineal gland cancer	29.9	ENO2 AFP
41	wilms tumor 1	29.8	POU5F1 KIT ENO2 AFP
42	testicular disease	29.8	TNFRSF8 POU5F1 MAGEA4 KIT DAZL AFP
43	disorder of sexual development	29.8	ESR2 DAZL AFP
44	cystic lymphangioma	29.7	PDPN AFP
45	sarcoma, synovial	29.5	TNFRSF8 SSX2 RASSF1 MAGEA4 KIT
46	ewing sarcoma	29.4	TNFRSF8 SSX2 RASSF1 POU5F1 KIT ENO2
47	testicular germ cell tumor	11.8
48	testis seminoma	11.4
49	testicular spermatocytic seminoma	11.2
50	tubular variant testicular seminoma	11.1

Graphical network of the top 20 diseases related to Seminoma:

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Symptoms & Phenotypes for Seminoma

MGI Mouse Phenotypes related to Seminoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	9.7	AFP CGB3 CGB5 CGB7 DAZL ESR2
2	reproductive system	MP:0005389	9.36	AFP ALPG CGB3 CGB5 CGB7 DAZL

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Drugs & Therapeutics for Seminoma

Drugs for Seminoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Granisetron

Approved, Investigational

Phase 3

109889-09-0

3510 5284566

Cisplatin

Approved

Phase 3

15663-27-1

2767 5702198 441203

Carboplatin

Approved

Phase 3

41575-94-4

10339178 38904

Etoposide

Approved

Phase 3

33419-42-0

36462

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 3

1177-87-3

3680

Lenograstim

Approved, Investigational

Phase 3

135968-09-1

Dexamethasone

Approved, Investigational, Vet_approved

Phase 3

50-02-2

3003 5743

Coenzyme M

Approved, Investigational

Phase 3

3375-50-6

598 23662354

Paclitaxel

Approved, Vet_approved

Phase 3

33069-62-4

36314

Diphenhydramine

Approved, Investigational

Phase 3

147-24-0, 58-73-1

3100

Promethazine

Approved, Investigational

Phase 3

60-87-7

4927

Bleomycin

Approved, Investigational

Phase 3

9041-93-4, 11056-06-7

5360373

Picropodophyllin

Approved, Investigational

Phase 3

518-28-5, 477-47-4

10607 72435

Neurotransmitter Agents

Phase 3

Antiemetics

Phase 3

Gastrointestinal Agents

Phase 3

Immunologic Factors

Phase 3

Albumin-Bound Paclitaxel

Phase 3

Etoposide phosphate

Phase 3

16760419

Adjuvants, Immunologic

Phase 3

Antimitotic Agents

Phase 3

Tubulin Modulators

Phase 3

Histamine H2 Antagonists

Phase 3

Anti-Bacterial Agents

Phase 3

Keratolytic Agents

Phase 3

Antibiotics, Antitubercular

Phase 3

Dermatologic Agents

Phase 3

Serotonin

Investigational, Nutraceutical

Phase 3

50-67-9

5202

Palbociclib

Approved, Investigational

Phase 2

571190-30-2

5330286

Levoleucovorin

Approved, Experimental, Investigational

Phase 2

68538-85-2, 58-05-9, 73951-54-9

149436 6006

Fluorouracil

Approved

Phase 2

51-21-8

3385

Oxaliplatin

Approved, Investigational

Phase 2

61825-94-3

43805 11947679 6857599

Ipilimumab

Approved

Phase 2

477202-00-9

Nivolumab

Approved

Phase 2

946414-94-4

Durvalumab

Approved, Investigational

Phase 2

1428935-60-7

Tremelimumab

Approved, Investigational

Phase 2

745013-59-6

Ifosfamide

Approved

Phase 2

3778-73-2

3690

Mechlorethamine

Approved, Investigational

Phase 2

51-75-2

4033

Folic acid

Approved, Nutraceutical, Vet_approved

Phase 2

59-30-3

6037

Lysine

Approved, Nutraceutical

Phase 2

56-87-1

5962

Alvocidib

Experimental, Investigational

Phase 2

131740-09-5, 146426-40-6

5466794 5287969

Palifosfamide

Investigational

Phase 2

31645-39-3

100427

Cyclin-Dependent Kinase Inhibitor Proteins

Phase 2

Vitamins

Phase 2

Folate

Phase 2

Vitamin B9

Phase 2

Hormones

Phase 2

Trace Elements

Phase 2

Antimetabolites

Phase 2

Vitamin B Complex

Phase 2

Interventional clinical trials:

(show all 31)

#	Name	Status	NCT ID	Phase	Drugs
1	Trial of Imaging and Schedule in Seminoma Testis	Unknown status	NCT00589537	Phase 3
2	A Study to Investigate the Efficacy and Tolerability of Two Dose Levels of Lerisetron Compared With Granisetron in Patients Receiving Radiotherapy for Stage I Seminoma	Unknown status	NCT00004219	Phase 3	granisetron hydrochloride;lerisetron
3	Carboplatin in the Adjuvant Treatment of Stage I Seminoma: A Radomized Comparison of Single Agent Carboplatin With Radiotherapy in the Adjuvant Treatment of Stage I Seminoma of the Testis, Following Orchidectomy	Completed	NCT00003014	Phase 3	carboplatin
4	A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel, Ifosfamide, and Cisplatin (TIP) With High-Dose Chemotherapy Using Mobilizing Paclitaxel Plus Ifosfamide Followed by High-Dose Carboplatin and Etoposide (TI-CE) as First Salvage Treatment in Relapsed or Refractory Germ Cell Tumors	Recruiting	NCT02375204	Phase 3	paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
5	A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors	Recruiting	NCT03067181	Phase 3	Carboplatin;Cisplatin;Etoposide
6	A Randomized Phase III Study Comparing One Course of Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) and One Course of Carboplatin AUC7 in Clinical Stage I Seminomatous Testicular Cancer	Recruiting	NCT02341989	Phase 3	Bleomycin Etoposide and Cisplatin;Carboplatin
7	Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer	Completed	NCT01037790	Phase 2	PD-0332991
8	A Non-randomized Phase 2 Study of Alvocidib (Flavopiridol) Plus Oxaliplatin With or Without 5-FU and Leucovorin for Relapsed or Refractory Germ-Cell Tumors	Completed	NCT00957905	Phase 2	Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
9	A Multi-Centre Phase II Study Using Carboplatin AUC-10 for Metastatic Seminoma With IGCCCG Good Prognosis Disease-Therapy Directed by Initial Metabolic Response on PET-CT	Completed	NCT02272816	Phase 2	Carboplatin AUC-10
10	A Prospective,Multicenter, Phase II Study to Evaluate the Contribution of the Imaging TEP to the Expression of intégrines αvβ3 for the Characterization of the Residual Masses of Non-seminoma Tumors at the End of Chemotherapy	Completed	NCT02317393	Phase 2
11	Therapeutic Strategy Guided by PET-TDM for Patients With Grade I or Metastatic Seminoma	Recruiting	NCT01887340	Phase 2	Carboplatin;Etoposide;Cisplatin
12	Reduced Intensity Radio-chemotherapy for Stage IIA/B Seminoma. A Multicenter, Open Label Phase II Trial With Two Cohorts	Recruiting	NCT03937843	Phase 2	Carboplatin;Cisplatin;Etoposide
13	Prospective Therapeutic De-escalation and miRNA-M371 Biomarker Evaluation Phase II Study for Stage IIa/IIb < 3 cm Seminomas	Recruiting	NCT05529251	Phase 2	Carboplatin AUC7;3 cycles of EP
14	A Phase II Trial Evaluating the Efficacy of Cabozantinib in the Treatment of Incurable Patients With Refractory Germ Cell Tumors	Recruiting	NCT04876456	Phase 2	Cabozantinib
15	DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors	Recruiting	NCT02834013	Phase 2
16	Carboplatin Chemotherapy and Involved Node Radiotherapy in Stage IIA/B Seminoma	Active, not recruiting	NCT01593241	Phase 2	Carboplatin
17	A Single-arm, Phase II Study of Durvalumab (MEDI4736) and Tremelimumab for Relapsed/Refractory Germ Cell Tumors	Active, not recruiting	NCT03158064	Phase 2	Durvalumab;Tremelimumab
18	Randomized Phase II Trial Evaluating Compliance With Monitoring Conducted Either by a Hospital-based Physician in Person or by a Nurse in Remote Monitoring	Not yet recruiting	NCT05500391	Phase 2
19	Multicenter Single Arm Phase II Study of Single Agent Palifosfamide in Recurrent and Incurable Germ Cell Tumors	Terminated	NCT01808534	Phase 2	palifosfamide
20	A Phase II Study Of Imatinib Mesylate (Gleevec, Formerly Known As STI571; IND 61,135, NSC #716051) In Patients With Refractory Seminoma	Terminated	NCT00042952	Phase 2	imatinib mesylate
21	Multicenter Phase 2 Trial of ARQ 197 for Subjects With Relapsed or Refractory Germ Cell Tumors	Terminated	NCT01055067	Phase 2	Tivantinib (ARQ 197)
22	CTLA-4 Blockade With MDX-010 to Induce Graft-Versus-Malignancy Effects Following Allogeneic Hematopoietic Stem Cell Transplantation	Completed	NCT00060372	Phase 1	ipilimumab;therapeutic allogeneic lymphocytes
23	Epigenetic Integrity of Spermatozoa in Patients With Germinal Testicular Tumours: Potential Risks and Consequences for the Conceptus	Unknown status	NCT03262207
24	A Phase II Study of Adjuvant Proton Radiation Therapy for the Treatment of Stage I, IIA and IIB Seminoma	Completed	NCT01557790
25	Cardiac Function and Cardiovascular Risk Profile in Testicular Cancer Patients	Completed	NCT00705094
26	Molecular Epidemiology of Pediatric Germ Cell Tumors	Completed	NCT01434355
27	MicroRNA-371 as Markers for Disease Activity and as a Tool to Monitor the Effect of Chemotherapy and Early Detection of Recurrence in Patients With Testicular Germ Cell Tumours	Recruiting	NCT04914026
28	Robotic Retroperitoneal Lymph Node Dissection (R-RPLND) as First-line Treatment for Clinical Stage IIA/B Testicular Seminoma	Recruiting	NCT05345158
29	A Prospective Observational Cohort Study to Assess miRNA 371 for Outcome Prediction in Patients With Newly Diagnosed Germ Cell Tumors	Recruiting	NCT04435756
30	Surgery in Early Metastatic Seminoma (SEMS): Phase II Trial of Retroperitoneal Lymph Node Dissection as First-Line Treatment for Testicular Seminoma With Isolated Retroperitoneal Disease (1-3cm)	Active, not recruiting	NCT02537548
31	FDG PET-CT Based Risk Adapted Radiotherapy vs Observation for Post Chemotherapy Residual Mass in Advanced Seminoma: A Prospective Randomised Controlled Trial	Not yet recruiting	NCT05142982

Search NIH Clinical Center for Seminoma

Cochrane evidence based reviews: seminoma

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Genetic Tests for Seminoma

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Anatomical Context for Seminoma

Organs/tissues related to Seminoma:

MalaCards : Testis, Lymph Node, Testes, Prostate, Ovary, Bone Marrow, Pineal

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Publications for Seminoma

Articles related to Seminoma:

(show top 50) (show all 5643)

#	Title	Authors	PMID	Year
1	TCL1 protein expression in testicular germ cell tumors. ⁵³ ⁶²	Lau SK...Chu PG	20395523	2010
2	SCF and c-kit expression profiles in male individuals with normal and impaired spermatogenesis. ⁵³ ⁶²	Bialas M...Kurpisz M	20384797	2010
3	Immunohistochemical expression of the KIT protein (CD117) in normal and neoplastic canine testes. ⁵³ ⁶²	Grieco V...Finazzi M	19683721	2010
4	Expression of embryonic stem cell markers in cultured JKT-1, a cell line derived from a human seminoma. ⁵³ ⁶²	Bouskine A...Fenichel P	19226408	2010
5	Analysis of activin/TGFB-signaling modulators within the normal and dysfunctional adult human testis reveals evidence of altered signaling capacity in a subset of seminomas. ⁵³ ⁶²	Dias VL...Loveland KL	19661148	2009
6	The utility of microscopic findings and immunohistochemistry in the classification of necrotic testicular tumors: a study of 11 cases. ⁵³ ⁶²	Miller JS...Ulbright TM	19461507	2009
7	Results of retroperitoneal lymph node dissection after chemotherapy in patients with pure seminoma in the orchidectomy specimen but elevated serum alpha-fetoprotein. ⁵³ ⁶²	Peterson M...Foster R	19493258	2009
8	Identification of ERbeta1 and ERbeta2 in human seminoma, in embryonal carcinoma and in their adjacent intratubular germ cell neoplasia. ⁵³ ⁶²	Rago V...Carpino A	19493328	2009
9	Yolk sac tumor but not seminoma or teratoma is associated with abnormal epigenetic reprogramming pathway and shows frequent hypermethylation of various tumor suppressor genes. ⁵³ ⁶²	Furukawa S...Kaneko Y	19245437	2009
10	Absence of gene mutations in KIT-positive thymic epithelial tumors. ⁵³ ⁶²	Tsuchida M...Hayashi JI	18486988	2008
11	Free beta-subunit of human chorionic gonadotropin in serum is a diagnostically sensitive marker of seminomatous testicular cancer. ⁵³ ⁶²	Lempiainen A...Hotakainen K	18787014	2008
12	[Place of serum HCG assay in the follow-up of non-HCG-secreting testicular seminomas]. ⁵³ ⁶²	Djeffal C...Petit J	18971108	2008
13	Expression of connexin 43 in normal canine testes and canine testicular tumors. ⁵³ ⁶²	Ruttinger C...Brehm R	18542985	2008
14	[Case report of malignant sertoli cell tumor]. ⁵³ ⁶²	Sassa N...Gotoh M	18697473	2008
15	Abnormal hCG levels in a patient with treated stage I seminoma: a diagnostic dilemma. ⁵³ ⁶²	Aherne NJ...Armstrong JG	18578862	2008
16	[Management of testicular seminoma with elevation of alpha fetoprotein. A case report]. ⁵³ ⁶²	Durand X...Houlgatte A	18472076	2008
17	Further characterization of the first seminoma cell line TCam-2. ⁵³ ⁶²	de Jong J...Looijenga LH	18050305	2008
18	A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors. ⁵³ ⁶²	Espinosa I...van de Rijn M	18223323	2008
19	Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. ⁵³ ⁶²	Iczkowski KA...MacLennan GT	18045648	2008
20	Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature. ⁵³ ⁶²	Coffey J...Rapley EA	17943970	2008
21	c-KIT is frequently mutated in bilateral germ cell tumours and down-regulated during progression from intratubular germ cell neoplasia to seminoma. ⁵³ ⁶²	Biermann K...Buttner R	17768701	2007
22	Complete response after treatment with imatinib in pretreated disseminated testicular seminoma with overexpression of c-KIT. ⁵³ ⁶²	Pedersini R...Graiff C	17976614	2007
23	Histologically pure stage I seminoma with an elevated beta-hCG of 4497 IU/l. ⁵³ ⁶²	Bjurlin MA...Totonchi E	18068467	2007
24	Aberrant expression and distribution of the OCT-4 transcription factor in seminomas. ⁵³ ⁶²	Cheng CJ...Huang YH	17682839	2007
25	Diffuse membranous immunoreactivity for podoplanin (D2-40) distinguishes primary and metastatic seminomas from other germ cell tumors and metastatic neoplasms. ⁵³ ⁶²	Yu H...Hornick JL	17951198	2007
26	KIT and RAS signalling pathways in testicular germ cell tumours: new data and a review of the literature. ⁵³ ⁶²	Goddard NC...Shipley J	17573850	2007
27	Classical and spermatocytic seminoma in the dog: histochemical and immunohistochemical findings. ⁵³ ⁶²	Grieco V...Finazzi M	17629966	2007
28	Kit expression in male germ cell tumors. ⁵³ ⁶²	Nikolaou M...Pectasides D	17595797	2007
29	DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer. ⁵³ ⁶²	Omisanjo OA...Steger K	16960727	2007
30	[CT diagnosis and pathological findings of testicular lesion]. ⁵³ ⁶²	Duan G...Zhang XD	17259159	2007
31	OCT4: biological functions and clinical applications as a marker of germ cell neoplasia. ⁵³ ⁶²	Cheng L...Looijenga LH	17117392	2007
32	Diagnostic value of markers M2A, OCT3/4, AP-2gamma, PLAP and c-KIT in the detection of extragonadal seminomas. ⁵³ ⁶²	Biermann K...Zhou H	16918976	2006
33	[A case of seminoma with a low level positive of serum hCG (human chorionic gonadotropin) beta considered as false positive hCGbeta]. ⁵³ ⁶²	Hattori Y...Noguchi K	17025215	2006
34	Detection of c-kit exons 11- and 17-activating mutations in testicular seminomas by high-resolution melting amplicon analysis. ⁵³ ⁶²	Willmore-Payne C...Layfield LJ	16741525	2006
35	Identity of M2A (D2-40) antigen and gp36 (Aggrus, T1A-2, podoplanin) in human developing testis, testicular carcinoma in situ and germ-cell tumours. ⁵³ ⁶²	Sonne SB...Rajpert-De Meyts E	16736189	2006
36	Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma. ⁵³ ⁶²	Mishima K...Matsutani M	16718353	2006
37	Transition from preinvasive carcinoma in situ to seminoma is accompanied by a reduction of connexin 43 expression in Sertoli cells and germ cells. ⁵³ ⁶²	Brehm R...Bergmann M	16820096	2006
38	Retroperitoneal seminoma in limited biopsies: morphologic criteria and immunohistochemical findings in 30 cases. ⁵³ ⁶²	Sung MT...Cheng L	16723857	2006
39	Rosai-Dorfman disease of the testis: an unusual entity that mimics testicular malignancy. ⁵³ ⁶²	Fernandopulle SM...Wong M	16505287	2006
40	Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. ⁵³ ⁶²	Schittenhelm MM...Heinrich MC	16397263	2006
41	Targeting the active site of the placental isozyme of alkaline phosphatase by phage-displayed scFv antibodies selected by a specific uncompetitive inhibitor. ⁵³ ⁶²	Saini D...Sinha S	16372914	2005
42	Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. ⁵³ ⁶²	Ezeh UI...Clark AT	16228988	2005
43	KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors. ⁵³ ⁶²	Nakai Y...Okuyama A	16188233	2005
44	Immunohistochemical expression of calretinin in canine testicular tumours and normal canine testicular tissue. ⁵³ ⁶²	Radi ZA...Miller DL	15924929	2005
45	CD30 (Ki-1) molecule expression in human embryonal epithelial cells of the basal layer of the developing epidermis and epidermal buds and its potential significance for embryogenesis. ⁵³ ⁶²	Tamiolakis D...Kouskoukis C	16200333	2005
46	Amplification and overexpression of the KIT gene is associated with progression in the seminoma subtype of testicular germ cell tumors of adolescents and adults. ⁵³ ⁶²	McIntyre A...Shipley J	16166280	2005
47	KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation. ⁵³ ⁶²	Miettinen M...Lasota J	16082245	2005
48	Estrogen-induced growth inhibition of human seminoma cells expressing estrogen receptor beta and aromatase. ⁵³ ⁶²	Roger C...Fenichel P	16087732	2005
49	Identification of two molecular groups of seminomas by using expression and tissue microarrays. ⁵³ ⁶²	Hofer MD...Rubin MA	16115909	2005
50	No predictive value of beta-hCG in patients with stage I seminoma--results of a long-term follow-up study after adjuvant radiotherapy. ⁵³ ⁶²	Bruns F...Micke O	16033057	2005

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Genes for Seminoma

Genes related to Seminoma (0 elite genes):

(show all 40)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	34.06	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	17768701 14695343 8551387 (more) 18045648 7514077 16166280 16741525 17595797 16918976 15822404 19255517 17573850 11927966 16397263 16188233 10362788 12752264 15902997 8609154 11896121 15542802 19461507 20410807 12379771 19226408 17943970 7529338 18486988 16056250 16767900 17976614 15471556 10824925 15316315 18223323 20384797 18050305 12893208 19683721 12824871 16082245
2	AFP	Alpha Fetoprotein	Protein Coding	25.51	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10386812 9769381 19493258 (more) 15828957 18472076 1378875 7509106 15242364 17259159 9474168 9258097 8653285 18697473 1723408 7525293 19461507 2158684 9805244 15272600
3	ALPG	Alkaline Phosphatase, Germ Cell	Protein Coding	25.25	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1310437 2187297 16115909 (more) 16723857 10547581 9657344 15316315 7569686 18045648 2311254 15132850 1949390 8386657 7543237
4	ALPP	Alkaline Phosphatase, Placental	Protein Coding	24	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	2273701 8653285 1646453 (more) 17629966 2311254 9491665 18045648 2148879 9112568 1310437 10359511 9879816 7490882 1716953 7509106 2248772 7602766 10204106 19683721 8688967 20410807 9670832 8791060 7569686 1723958 16505287 9823315 8691601 7508884 16372914 10743701 15132850 1949390 1874301 1868303 2076869 18050305 1302092 12657943 11825120 19255517 7524297 8912826
5	CGB3	Chorionic Gonadotropin Subunit Beta 3	Protein Coding	22.6	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1372658 8394368 1711586 (more) 16033057 7509106 17025215 11489712 12910930
6	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	21.69	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8912826 16200333 15644135 (more) 11838744 8200647 9670832
7	POU5F1	POU Class 5 Homeobox 1	Protein Coding	21.48	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15725806 17682839 17117392
8	PDPN	Podoplanin	Protein Coding	20.97	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17951198 19483629 16670463 (more) 16718353 16736189
9	CGB5	Chorionic Gonadotropin Subunit Beta 5	Protein Coding	19.19	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10843453 1694252 18068467 (more) 18787014 7690985 1378875 18697473 17025215
10	RAD17	RAD17 Checkpoint Clamp Loader Component	Protein Coding	19.12	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Functions (show sections)
11	MAGEA4	MAGE Family Member A4	Protein Coding	19.11	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11753951 12605640 17993720
12	SSX2	SSX Family Member 2	Protein Coding	18.65	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11454979 9639388
13	CGB7	Chorionic Gonadotropin Subunit Beta 7	Protein Coding	18.55	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11005453 18578862 1716953 (more) 8653285
14	ENO2	Enolase 2	Protein Coding	18.33	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	2204171 12852696 1645819 (more) 1739633 8392765 1947758 8683382
15	TCL1A	TCL1 Family AKT Coactivator A	Protein Coding	18.23	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	20395523 12181493 12962701
16	INHA	Inhibin Subunit Alpha	Protein Coding	18.06	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19255517 9365168 15056223 (more) 19661148
17	DAZL	Deleted In Azoospermia Like	Protein Coding	16.86	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11956819 16228988
18	RASSF1	Ras Association Domain Family Member 1	Protein Coding	16.3	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12545168
19	TSPY1	Testis Specific Protein Y-Linked 1	Protein Coding	15.94	GeneCards inferred via : Disorders Publications (show sections)
20	ESR2	Estrogen Receptor 2	Protein Coding	15.94	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16087732 14644130 19493328
21	IGF2	Insulin Like Growth Factor 2	Protein Coding	15.67	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15967097
22	MMP16	Matrix Metallopeptidase 16	Protein Coding	15.37	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11215209
23	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	14.96	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18971108 9311009 10559615 (more) 9610904 18578862 1892008 1739633 1689221 15272600 9805244 9258097 9187899
24	NME1	NME/NM23 Nucleoside Diphosphate Kinase 1	Protein Coding	14.52	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9143023
25	DMRT1	Doublesex And Mab-3 Related Transcription Factor 1	Protein Coding	14.5	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
26	SOX2	SRY-Box Transcription Factor 2	Protein Coding	14.42	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
27	CDH13	Cadherin 13	Protein Coding	14.36	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12545168
28	NLRP7	NLR Family Pyrin Domain Containing 7	Protein Coding	14.28	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15596043
29	NANOG	Nanog Homeobox	Protein Coding	14.27	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
30	GJA1	Gap Junction Protein Alpha 1	Protein Coding	14.27	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16820096 14743507 12210085 (more) 18542985
31	SOX17	SRY-Box Transcription Factor 17	Protein Coding	14.2	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
32	TFAP2C	Transcription Factor AP-2 Gamma	Protein Coding	14.03	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
33	TDRG1	Testis Development Related 1	RNA Gene	13.67	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
34	TP53	Tumor Protein P53	Protein Coding	13.64	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
35	GPER1	G Protein-Coupled Estrogen Receptor 1	Protein Coding	13.61	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
36	CCND2	Cyclin D2	Protein Coding	13.19	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9056671 15747581 14612934
37	SLC43A1	Solute Carrier Family 43 Member 1	Protein Coding	13.12	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	16115909 14612934
38	KLF4	KLF Transcription Factor 4	Protein Coding	12.94	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
39	PRAME	PRAME Nuclear Receptor Transcriptional Regulator	Protein Coding	12.84	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
40	ESR1	Estrogen Receptor 1	Protein Coding	12.79	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)

Sources

Variations for Seminoma

Copy number variations for Seminoma from CNVD:

⁶ (show all 13)

#	CNVD ID	Chromosome	Start	End	Type	CNVD Disease
1	55928	11	56400000	134452384	Loss	Seminomas
2	61576	12	1	56300000	Gain	Seminomas
3	119165	18	1	15400000	Loss	Seminomas
4	120979	18	35500000	76117153	Loss	Seminomas
5	138723	2	169500000	182700000	Gain	Seminomas
6	146936	2	56300000	182700000	Loss	Seminomas
7	157118	21	12300000	46944323	Gain	Seminomas
8	160299	22	11800000	49691432	Loss	Seminomas
9	217037	7	1	158821424	Gain	Seminomas
10	237233	8	2200000	146274826	Gain	Seminomas
11	257126	X	1	24900000	Gain	Seminomas
12	262546	X	37500000	154913754	Gain	Seminomas
13	262571	X	37500000	47300000	Gain	Seminomas

Sources

Expression for Seminoma

Search GEO for disease gene expression data for Seminoma.

Sources

Pathways for Seminoma

Pathways related to Seminoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers ⁶⁵	11.46	POU5F1 ALPP AFP
2	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors ⁶⁶ Show member pathways Activation of the TFAP2 (AP-2) family of transcription factors ⁶⁶ Negative regulation of activity of TFAP2 (AP-2) family transcription factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of cell cycle factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ⁶⁶ TFAP2 (AP-2) family regulates transcription of other transcription factors ⁶⁶ TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation ⁶⁶	11.08	KIT CGB5 CGB3
3	Ovarian infertility ⁷⁴	10.36	INHA ESR2 DAZL