MCID: SMN007
MIFTS: 47

Seminoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Seminoma

MalaCards integrated aliases for Seminoma:

Name: Seminoma 12 76 55 44 15 73
Seminoma, Pure 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4440
MeSH 44 D018239
NCIt 50 C7328 C9309
SNOMED-CT 68 36741007
UMLS 73 C0036631

Summaries for Seminoma

Disease Ontology : 12 A germinoma that has material basis in cells that make sperm and eggs.

MalaCards based summary : Seminoma, also known as seminoma, pure, is related to testicular seminoma and spermatocytoma. An important gene associated with Seminoma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Peptide hormone metabolism and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Granisetron and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include testis, bone and lymph node, and related phenotype is digestive/alimentary.

Wikipedia : 76 Seminoma (also known as pure seminoma or classical seminoma) is a germ cell tumor of the testicle or,... more...

Related Diseases for Seminoma

Diseases related to Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 239)
# Related Disease Score Top Affiliating Genes
1 testicular seminoma 34.0 AFP CGA CGB3 TSPY1
2 spermatocytoma 33.3 KIT MAGEA4
3 testicular germ cell tumor 33.2 AFP ALPG ALPP CGB3 FGFR3 KIT
4 extragonadal seminoma 33.2 AFP KIT POU5F1 TNFRSF8
5 embryonal carcinoma 32.2 AFP KIT POU5F1 TNFRSF8
6 nonseminomatous germ cell tumor 31.8 AFP CGB5 CGB7
7 cryptorchidism, unilateral or bilateral 30.6 ALPG CGA CGB5
8 gonadoblastoma 30.5 ALPP KIT TSPY1
9 dysgerminoma 30.1 AFP ALPP ENO2 KIT TSPY1
10 germ cell cancer 30.1 AFP ALPG ALPP CGA ESR2 KIT
11 testicular cancer 30.0 AFP ALPP CGA CGB3 CGB5 MAGEA4
12 teratoma 30.0 AFP CGA CGB3 ENO2 KIT POU5F1
13 malignant teratoma 29.9 AFP ENO2 POU5F1
14 extragonadal germ cell cancer 29.9 AFP CGB5 POU5F1
15 mature teratoma 29.7 AFP POU5F1
16 mixed germ cell tumor 29.7 AFP CGA CGB3 KIT
17 malignant sertoli cell tumor 29.5 AFP CGB5 ENO2
18 choriocarcinoma 29.5 ALPG ALPP CGA CGB3 CGB5 CGB7
19 intratubular embryonal carcinoma 29.3 AFP KIT POU5F1 TNFRSF8
20 testis seminoma 12.3
21 testicular spermatocytic seminoma 12.2
22 mediastinum seminoma 12.2
23 tubular variant testicular seminoma 12.0
24 cribriform variant testicular seminoma 12.0
25 pseudoglandular variant testicular seminoma 12.0
26 mixed germ cell cancer 11.0
27 ovarian mixed germ cell neoplasm 10.2 AFP CGA
28 germ cells tumors 10.2
29 hepatic angiomyolipoma 10.2 AFP KIT
30 polyembryoma 10.2 AFP CGA
31 testicular malignant germ cell cancer 10.2 AFP ALPP
32 tuberculous epididymitis 10.2 AFP CGB3
33 central nervous system germinoma 10.2 ALPP POU5F1
34 brain germinoma 10.2 AFP POU5F1
35 sarcoma 10.2
36 luteoma 10.2 CGA FGFR3
37 endodermal sinus tumor 10.2
38 central nervous system germ cell tumor 10.2 AFP POU5F1
39 embryonal testis carcinoma 10.2 AFP POU5F1
40 mixed germ cell-sex cord neoplasm 10.2 KIT POU5F1 TSPY1
41 mixed type thymoma 10.2 KIT PDPN
42 corpus luteum cyst 10.2 AFP CGB5
43 chromosomal triplication 10.2 AFP CGA CGB3
44 anorchia 10.2 CGA CGB5
45 epithelioid trophoblastic tumor 10.2 CGB3 INHA
46 pediatric ovarian germ cell tumor 10.2 ALPP ENO2
47 sarcomatoid renal cell carcinoma 10.2 CGB3 KIT
48 sacrococcygeal teratoma 10.2 AFP CGA CGB7
49 pediatric ovarian dysgerminoma 10.2 ALPP ENO2
50 triploidy 10.2 AFP CGA CGB7

Graphical network of the top 20 diseases related to Seminoma:



Diseases related to Seminoma

Symptoms & Phenotypes for Seminoma

MGI Mouse Phenotypes related to Seminoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.17 ESR2 FGFR3 INHA KIT MMP16 PDPN

Drugs & Therapeutics for Seminoma

Drugs for Seminoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 136)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
2
Paclitaxel Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 33069-62-4 36314
3
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
4
Bleomycin Approved, Investigational Phase 2, Phase 3,Phase 3 11056-06-7 5360373
5
Etoposide Approved Phase 2, Phase 3,Phase 3 33419-42-0 36462
6
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1 15663-27-1 2767 441203 84093
7
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
8
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
9
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
10
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2 50-02-2 5743
11
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2 1177-87-3
12
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2 3375-50-6 598
13
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
14
Captopril Approved Phase 3 62571-86-2 44093
15
Ribavirin Approved Phase 3 36791-04-5 37542
16
Palivizumab Approved, Investigational Phase 3 188039-54-5
17
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
18
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
19
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
20
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
21
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
22
Ondansetron Approved Phase 3 99614-02-5 4595
23
Promethazine Approved, Investigational Phase 3 60-87-7 4927
24
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
25
Vinblastine Approved Phase 3 865-21-4 241903 13342
26 Autonomic Agents Phase 3,Phase 2
27 Antiemetics Phase 3,Phase 2
28 Neurotransmitter Agents Phase 3
29 Serotonin Antagonists Phase 3
30 Serotonin Agents Phase 3
31 Gastrointestinal Agents Phase 3,Phase 2
32 Peripheral Nervous System Agents Phase 3,Phase 2
33 Albumin-Bound Paclitaxel Phase 2, Phase 3,Phase 3,Phase 1
34 Etoposide phosphate Phase 2, Phase 3,Phase 3
35 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 3,Phase 1
36 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 3
37 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 3
38 Antimitotic Agents Phase 2, Phase 3,Phase 3,Phase 1
39 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3
40 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
41 Immunologic Factors Phase 3,Phase 1,Phase 2
42 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
43 Alkylating Agents Phase 3,Phase 1,Phase 2
44 Antimetabolites Phase 3,Phase 1,Phase 2
45 Anti-Infective Agents Phase 3,Phase 1,Phase 2
46 Antiviral Agents Phase 3,Phase 1,Phase 2
47 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
48 Hormones Phase 3,Phase 2,Phase 1
49 Hormone Antagonists Phase 3,Phase 2,Phase 1
50
Isophosphamide mustard Phase 3,Phase 1,Phase 2 0

Interventional clinical trials:

(show top 50) (show all 56)
# Name Status NCT ID Phase Drugs
1 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
2 Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
3 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
4 Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer Completed NCT00003014 Phase 3 carboplatin
5 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
6 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
7 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
8 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
9 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
10 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
11 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
12 Ondansetron With or Without Dexamethasone to Prevent Vomiting in Patients Receiving Radiation Therapy to the Upper Abdomen Completed NCT00016380 Phase 3 dexamethasone;ondansetron
13 Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer Recruiting NCT02341989 Phase 3 Bleomycin Etoposide and Cisplatin;Carboplatin
14 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
15 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
16 Proton Radiotherapy for Stage I, IIA, and IIB Seminoma Unknown status NCT01557790 Phase 2
17 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
18 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
19 Carboplatin AUC-10 With Early PET Scanning in Metastatic Seminoma Completed NCT02272816 Phase 2 Carboplatin AUC-10
20 ARQ 197 for Subjects With Relapsed or Refractory Germ Cell Tumors Completed NCT01055067 Phase 2 Tivantinib (ARQ 197)
21 Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
22 Docetaxel in Treating Patients With Recurrent or Refractory Germ Cell Cancer Completed NCT00002903 Phase 2 docetaxel
23 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
24 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
25 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
26 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
27 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
28 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
29 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
30 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
31 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
32 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
33 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
34 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
35 Therapeutic Strategy Guided by PET-TDM for Patients With Seminoma Recruiting NCT01887340 Phase 2 Carboplatin;Etoposide;Cisplatin
36 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
37 Evaluating Immune Therapy, Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors Recruiting NCT03158064 Phase 2 Durvalumab;Tremelimumab
38 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Recruiting NCT01037790 Phase 2 PD-0332991
39 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
40 Therapy De-escalation in Seminoma Stage IIA/B Active, not recruiting NCT01593241 Phase 2 Carboplatin
41 Imatinib Mesylate in Treating Patients With Progressive, Refractory, or Recurrent Stage II or Stage III Testicular or Ovarian Cancer Terminated NCT00042952 Phase 2 imatinib mesylate
42 Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
43 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
44 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
45 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
46 Analysis of Transposon Control Pathways in Germinal Cancers of the Testicle Unknown status NCT02873793
47 REtrospective Study of TESTIcular CAncer Patients at the University Magdeburg Completed NCT02092740
48 Cardiac Function and Cardiovascular Risk Profile in Testicular Cancer Patients Completed NCT00705094
49 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Completed NCT01434355
50 Positron Emission Tomography in Detecting Testicle Cancer Completed NCT00045045 Not Applicable

Search NIH Clinical Center for Seminoma

Cochrane evidence based reviews: seminoma

Genetic Tests for Seminoma

Anatomical Context for Seminoma

MalaCards organs/tissues related to Seminoma:

41
Testis, Bone, Lymph Node, Bone Marrow, Prostate, Kidney, Liver

Publications for Seminoma

Articles related to Seminoma:

(show top 50) (show all 1334)
# Title Authors Year
1
Clinical Stage IIA-IIC Seminoma: Radiation Therapy versus Systemic Chemotherapy versus Retroperitoneal Lymph Node Dissection. ( 29763926 )
2018
2
Retroperitoneal seminoma, a rare cause of testicular pain. ( 29903776 )
2018
3
Nodular Hepatic Tuberculosis Masquerading as a Seminoma Liver Metastasis. ( 29693409 )
2018
4
Superior vena cava obstruction by metastatic mediastinal testicular seminoma. Imaging of collateral pathways during gastrointestinal bleeding scintigraphy with <sup>99m</sup>Tc labeled red blood cells. ( 29636233 )
2018
5
Expression of terminal deoxynucleotidyl transferase (TdT) in classical seminoma: a potential diagnostic pitfall. ( 29455318 )
2018
6
Granulomatous reaction of primary mediastinal seminoma leading to diagnostic delay: a case report. ( 29607195 )
2018
7
Large intra-abdominal seminoma in a left undescended testicle complicated by torsion. ( 29599382 )
2018
8
Carboplatin dose based on actual renal function: no excess of acute haematotoxicity in adjuvant treatment in seminoma stage I. ( 29531843 )
2018
9
Controversies in the Management of Clinical Stage I Seminoma: Carboplatin a Decade in-Time to Start Backing Out. ( 29389229 )
2018
10
Bilateral synchronous testicular seminoma: A rare presentation of a rare disease. ( 29633802 )
2018
11
Current Practice Patterns Surrounding Fertility Concerns in Stage I Seminoma Patients: Survey of United States Radiation Oncologists. ( 29336660 )
2018
12
Peritoneal Myeloid Sarcoma in a Patient Treated for a Testicular Seminoma. ( 29955031 )
2018
13
Synchronous Leydig Cell Tumor and Seminoma in the Ipsilateral Testis. ( 29670803 )
2018
14
Testicular orphan receptor 4 promotes tumor progression and implies poor survival through AKT3 regulation in seminoma. ( 29197138 )
2018
15
Metastatic &amp;quot;Burned Out&amp;quot; Seminoma Causing Neurological Paraneoplastic Syndrome-Not Quite &amp;quot;Burned Out&amp;quot;. ( 29441039 )
2018
16
Prognostic markers in clinical stage I seminoma and nonseminomatous germ cell tumours. ( 29979237 )
2018
17
Seminoma Metastatic to the Orbit. ( 29334543 )
2018
18
Distinct telomere length and molecular signatures in seminoma and non-seminoma of testicular germ cell tumor. ( 29579225 )
2018
19
Paratesticular seminoma: echographic features and histological diagnosis with review of the literature. ( 29411910 )
2018
20
Testicular seminoma: Scattered radiation dose to the contralateral testis in the modern era. ( 29306641 )
2018
21
On thin ice: barriers to adoption of surveillance for patients with stage I testicular seminoma. Survey of US radiation oncologists. ( 29522295 )
2018
22
Foreign-body granuloma mimicking post-chemotherapy residual seminoma: A case of true-negative findings using diffusion-weighted whole-body magnetic resonance imaging with background suppression. ( 29719857 )
2018
23
A Risk-Adapted Approach to Patients with Stage I Seminoma according to the Status of Rete Testis: The Fourth Spanish Germ Cell Cancer Group Study. ( 29587278 )
2018
24
Retroperitoneal Lymph Node Dissection as Primary Treatment for Metastatic Seminoma. ( 29487620 )
2018
25
Prognostic factors for relapse in stage I testicular seminoma: tumor size and rete testis invasion revisited. ( 29744734 )
2018
26
Spontaneous rupture of seminoma in undescended testis with hemoperitoneum: a rare presentation. ( 29674406 )
2018
27
Retroperitoneal extragonadal seminoma developed with acute lower inferior vena cava syndrome: A case report. ( 30069432 )
2018
28
Laparoscopic Management of Chylous Leakage Using a Direct Lymph Node Injection with Methylene Blue as a Leakage Point Location Strategy in a Patient with Retroperitoneal Extragonadal Seminoma. ( 30263965 )
2018
29
Questioning the Value of Fluorodeoxyglucose Positron Emission Tomography for Residual Lesions After Chemotherapy for Metastatic Seminoma: Results of an International Global Germ Cell Cancer Group Registry. ( 30285559 )
2018
30
Malignant Sertoli cell tumor of the testis masquerading as seminoma with bone metastasis. ( 30303161 )
2018
31
Seminoma with Neoplastic Meningitis Treated with Craniospinal Irradiation. ( 30012875 )
2018
32
Controversies in the management of stage I seminoma: adjuvant carboplatin revisited. ( 29992462 )
2018
33
Incomplete methylation of a germ cell tumor (Seminoma) in a Prader-Willi male. ( 30003711 )
2018
34
Spermatocytic seminoma with rhabdomyoblastic differentiation: Case report and review of literature. ( 30004076 )
2018
35
Surgical resection of a giant polycystic seminoma of the mediastinum. ( 30069400 )
2018
36
A case of spermatocytic seminoma in young individual. ( 30093773 )
2018
37
Metachronous Testicular Seminoma After Testicular Tumor. ( 30145557 )
2018
38
Primary mediastinal seminoma. ( 30174881 )
2018
39
Thoracoscopic resection of a cystic seminoma of the mediastinum. ( 30187669 )
2018
40
SPIN1 is a proto-oncogene and SPIN3 is a tumor suppressor in human seminoma. ( 30197756 )
2018
41
Bilateral Malignant Seminoma With Ventricular Metastasis in a Bald Eagle ( Haliaeetus leucocephalus). ( 30204011 )
2018
42
Seminoma component of mixed testicular germ cell tumor shows a higher incidence of loss of heterozygosity than pure-type seminoma. ( 30266250 )
2018
43
Ultrasonographic features of testicular metastasis from renal clear cell carcinoma that mimics a seminoma: A case report. ( 30290683 )
2018
44
Sperm imprinting integrity in seminoma patients? ( 30340650 )
2018
45
Exploring the spectrum of late effects following radical orchidectomy for stage I testicular seminoma: a systematic review of the literature. ( 30350189 )
2018
46
Testicular seminoma in the aged rat visualized by phase-contrast X-ray computed tomography. ( 30377541 )
2018
47
Long non-coding RNA H19 promotes TDRG1 expression and cisplatin resistance by sequestering miRNA-106b-5p in seminoma. ( 30430771 )
2018
48
Mediastinal seminoma presenting as a neck mass falsely diagnosed as anaplastic thyroid carcinoma: A case report. ( 30468316 )
2018
49
CSE1L participates in regulating cell mitosis in human seminoma. ( 30485574 )
2018
50
Mediastinal seminoma associated with multilocular thymic cyst. ( 28054283 )
2017

Variations for Seminoma

Copy number variations for Seminoma from CNVD:

7 (show all 13)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 55928 11 56400000 134452384 Loss Seminomas
2 61576 12 1 56300000 Gain Seminomas
3 119165 18 1 15400000 Loss Seminomas
4 120979 18 35500000 76117153 Loss Seminomas
5 138723 2 169500000 182700000 Gain Seminomas
6 146936 2 56300000 182700000 Loss Seminomas
7 157118 21 12300000 46944323 Gain Seminomas
8 160299 22 11800000 49691432 Loss Seminomas
9 217037 7 1 158821424 Gain Seminomas
10 237233 8 2200000 146274826 Gain Seminomas
11 257126 X 1 24900000 Gain Seminomas
12 262546 X 37500000 154913754 Gain Seminomas
13 262571 X 37500000 47300000 Gain Seminomas

Expression for Seminoma

Search GEO for disease gene expression data for Seminoma.

GO Terms for Seminoma

Cellular components related to Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 AFP CGA CGB3 CGB5 CGB7 ENO2
2 extracellular region GO:0005576 9.32 AFP ALPG CGA CGB3 CGB5 CGB7

Biological processes related to Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.72 CGA CGB3 CGB5 CGB7 INHA
2 hormone-mediated signaling pathway GO:0009755 9.43 CGB3 CGB5 CGB7
3 chondrocyte proliferation GO:0035988 9.37 FGFR3 MMP16
4 peptide hormone processing GO:0016486 9.33 CGA CGB3 CGB5
5 female gamete generation GO:0007292 9.13 CGB3 CGB5 CGB7
6 cell-cell signaling GO:0007267 9.1 CGB3 CGB5 CGB7 ESR2 FGFR3 INHA

Molecular functions related to Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 alkaline phosphatase activity GO:0004035 8.96 ALPG ALPP
2 hormone activity GO:0005179 8.92 CGA CGB3 CGB7 INHA

Sources for Seminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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