Senile Angioma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Senile Angioma

MalaCards integrated aliases for Senile Angioma:

Name: Senile Angioma ¹² ¹⁵ ⁷³

Senile Naevus of Skin ¹²

Senile Hemangioma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2495

NCIt ⁵⁰ C4390

SNOMED-CT ⁶⁸ 11790000 5050001

UMLS ⁷³ C0343082

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Summaries for Senile Angioma

MalaCards based summary : Senile Angioma, also known as senile naevus of skin, is related to mast-cell sarcoma and malignant mixed mullerian tumor. An important gene associated with Senile Angioma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and Endometrial cancer. The drugs Octreotide and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include skin, b cells and endothelial, and related phenotypes are Reduced mammosphere formation and cellular

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Related Diseases for Senile Angioma

Diseases related to Senile Angioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)

#	Related Disease	Score	Top Affiliating Genes
1	mast-cell sarcoma	10.8	KIT VIM
2	malignant mixed mullerian tumor	10.8	KIT VIM
3	benign breast phyllodes tumor	10.8	KIT VIM
4	perivascular epithelioid cell tumor	10.7	KIT VIM
5	ovarian melanoma	10.7	KIT MAP2K1
6	perineurioma	10.7	KIT VIM
7	pulmonary vein stenosis	10.7	KDR KIT
8	dermoid cyst	10.7	KIT VIM
9	embryonal sarcoma	10.6	KIT VIM
10	smooth muscle tumor	10.6	KIT VIM
11	rete testis adenocarcinoma	10.6	KIT THBD
12	gallbladder leiomyoma	10.6	CD34 KIT
13	lung leiomyosarcoma	10.6	CD34 KIT
14	adenomatoid tumor	10.6	THBD VIM
15	liver leiomyoma	10.6	CD34 KIT
16	8p11 myeloproliferative syndrome	10.6	KDR KIT
17	deep leiomyoma	10.6	CD34 KIT
18	extracutaneous mastocytoma	10.6	CD34 KIT
19	polymorphous low-grade adenocarcinoma	10.5	KIT VIM
20	rete testis neoplasm	10.5	KIT THBD
21	small intestine leiomyosarcoma	10.5	CD34 KIT
22	small intestinal sarcoma	10.5	CD34 KIT
23	glomangiomyoma	10.5	CD34 VIM
24	gallbladder sarcoma	10.5	CD34 KIT
25	prostate leiomyosarcoma	10.5	CD34 KIT
26	sternum cancer	10.5	CD34 VIM
27	diffuse cutaneous mastocytosis	10.5	CD34 KIT
28	sarcomatoid squamous cell skin carcinoma	10.5	CD34 KIT
29	adenoid squamous cell carcinoma	10.5	HBA1 VIM
30	gastric leiomyosarcoma	10.5	CD34 KIT
31	plexiform schwannoma	10.5	CD34 KIT
32	conventional fibrosarcoma	10.5	CD34 KIT
33	cavernous hemangioma	10.4	KDR KIT VIM
34	mast-cell leukemia	10.4	KDR KIT
35	angiosarcoma	10.4	KDR KIT VIM
36	kaposiform hemangioendothelioma	10.4	CD34 KDR
37	capillary hemangioma	10.4	HBA1 KDR
38	skin hemangioma	10.4	HBA1 KDR
39	hemangiopericytoma, malignant	10.3	HBA1 VIM
40	ovary sarcoma	10.3	CD34 HBA1
41	ovarian angiosarcoma	10.3	CD34 HBA1
42	intravascular fasciitis	10.3	CD34 HBA1
43	pediatric angiosarcoma	10.3	CD34 HBA1
44	thyroid angiosarcoma	10.3	CD34 HBA1
45	benign mesothelioma	10.3	THBD VIM
46	neurogenic arthropathy	10.3	CD34 HBA1
47	malignant dermis tumor	10.3	HBA1 KIT
48	spleen angiosarcoma	10.3	CD34 HBA1
49	bone epithelioid hemangioma	10.3	CD34 HBA1
50	thyroid sarcoma	10.3	CD34 HBA1

Graphical network of the top 20 diseases related to Senile Angioma:

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Symptoms & Phenotypes for Senile Angioma

GenomeRNAi Phenotypes related to Senile Angioma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.02	CCNE1 CD34 HSP90AA1 KDR VIM

MGI Mouse Phenotypes related to Senile Angioma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.76	CCNE1 CD34 HSP90AA1 KDR KIT MAP2K1
2	embryo	MP:0005380	9.43	CCNE1 KDR KIT MAP2K1 THBD VIM
3	integument	MP:0010771	9.1	CCNE1 CD34 KDR KIT MAP2K1 THBD

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Drugs & Therapeutics for Senile Angioma

Drugs for Senile Angioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Octreotide

Approved, Investigational

Phase 2

83150-76-9

383414 6400441

Synonyms:

(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide

10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa

10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide

10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide

79517-01-4 (acetate salt)

83150-76-9

AC1L1GVU

AC1L8LCD

AC1L9M4X

C07306

C5H12O2.C4H10

CHEBI:427278

CHEBI:611465

CHEMBL1680

CID383414

CID448601

CID54374

Compound 201 995

Compound 201995

Compound 201-995

D00442

D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide

D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide

D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide

DRG-0115

HMS2090C09

HS-2020

L000453

L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*

Longastatin

LS-177735

LS-187135

NCGC00181796-01

nchembio.184-comp3

NCI60_025753

Octreotida

Octreotida [Spanish]

Octreotide

Octreotide (USAN/INN)

Octreotide [USAN:INN:BAN]

Octreotide acetate

Octreotide acetate salt

Octreotide Acetate Salt

Octreotide-LAR

Octreotidum

Octreotidum [Latin]

Octrotide

SAN 201-995

Sandostatin

Sandostatine

Sandoz 201 995

Sandoz 201995

Sandoz 201-995

SM 201-995

SMS 201-995

SMS-201-995

UNII-RWM8CCW8GP

zacycloicosane-4-carboxamide acetate

2

Somatostatin

Approved, Investigational

Phase 2

38916-34-6, 51110-01-1

53481605

3

Antineoplastic Agents, Hormonal

Phase 2

4

Gastrointestinal Agents

Phase 2

5

Hormones

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Phase II Pilot Study of Octreotide, a Somatostatin Octapeptide Analog, for Gastrointestinal Hemorrhage in Hormone-Refractory Hereditary Hemorrhagic Telangiectasia and Senile Ectasia	Completed	NCT00004327	Phase 2	octreotide
2	Comparison of Electrodessication, Potassium Titanyl Phosphate (KTP) Laser and Pulsed Dye Laser for Treatment of Cherry Angiomata	Completed	NCT00791908	Not Applicable

Search NIH Clinical Center for Senile Angioma

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Genetic Tests for Senile Angioma

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Anatomical Context for Senile Angioma

MalaCards organs/tissues related to Senile Angioma:

⁴¹

Skin, B Cells, Endothelial

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Publications for Senile Angioma

Articles related to Senile Angioma:

#	Title	Authors	Year
1	Intravascular large B cell lymphoma with neurological symptoms diagnosed on the basis of a senile angioma-like eruption. ( 21686374 )	Nakamura Y....Tamaoka A.	2009
2	Prichard's structures of the fossa ovalis are age-related phenomena composed of nonreplicating endothelial cells: the cardiac equivalent of cutaneous senile angioma. ( 18092955 )	Val-Bernal J.F....Garijo M.F.	2007
3	Senile angioma-like eruption: a skin manifestation of intravascular large B cell lymphoma. ( 15316168 )	Motegi S....Ishikawa O.	2004
4	Intravascular large B cell lymphoma diagnosed by senile angioma biopsy. ( 12583632 )	Satoh S....Hachyou M.	2003
5	[Clinical features and histology of angioma. III. Histology and pathogenesis of senile angioma]. ( 13198143 )	Schnyder U.W....Keller R.	1954

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Genes for Senile Angioma

Genes related to Senile Angioma (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KIT	KIT Proto-Oncogene Receptor Tyrosine Kinase	Protein Coding	20.58	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	VIM	Vimentin	Protein Coding	17.18	GeneCards inferred via : Publications (show sections)
3	CCNE1	Cyclin E1	Protein Coding	14.99	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	KDR	Kinase Insert Domain Receptor	Protein Coding	14.57	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	14.41	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	THBD	Thrombomodulin	Protein Coding	14.14	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	14	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	HBA1	Hemoglobin Subunit Alpha 1	Protein Coding	13.59	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	TF	Transferrin	Protein Coding	13.41	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	IVL	Involucrin	Protein Coding	5.67	DISEASES inferred ¹⁵
11	CD34	CD34 Molecule	Protein Coding	3.04	DISEASES inferred ¹⁵

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Variations for Senile Angioma

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Expression for Senile Angioma

Search GEO for disease gene expression data for Senile Angioma.

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Pathways for Senile Angioma

Pathways related to Senile Angioma according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Nanog in Mammalian ESC Pluripotency ⁶⁴ Show member pathways 14-3-3 Induced Intracellular Signaling ⁶⁴ eNOS Signaling ⁶⁴ GSK3 Signaling ⁶⁴	12.88	HSP90AA1 KDR KIT MAP2K1 VIM
2	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.5	CCNE1 HSP90AA1 KIT MAP2K1
3	Pathways in cancer ³⁷	12.43	CCNE1 HSP90AA1 KIT MAP2K1
4	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.18	CCNE1 HSP90AA1 KDR KIT MAP2K1
5	EPH-Ephrin signaling ⁶⁶ Show member pathways Cell adhesion Ephrins signaling ²² Cytoskeleton remodeling Fibronectin-binding integrins in cell motility ²² EPHB forward signaling ¹ EPHB-mediated forward signaling ⁶⁶ EPH-ephrin mediated repulsion of cells ⁶⁶ Ephrin signaling ⁶⁶ EphrinB-EPHB pathway ¹ MAP kinase cascade ¹	12.16	HSP90AA1 KDR MAP2K1 TF
6	Oocyte meiosis ³⁷ Show member pathways Progesterone-mediated oocyte maturation ³⁷	12.02	CCNE1 HSP90AA1 MAP2K1
7	Fluid shear stress and atherosclerosis ³⁷	11.69	HSP90AA1 KDR THBD
8	Corticotropin-releasing hormone signaling pathway ¹	11.4	HSP90AA1 IVL MAP2K1
9	VEGF Pathway (Tocris) ⁷² Show member pathways Sorafenib Pharmacodynamics ⁶¹	11.25	KDR KIT MAP2K1
10	Validated transcriptional targets of AP1 family members Fra1 and Fra2 ¹	11.01	IVL THBD
11	Dendritic Cells Developmental Lineage Pathway ⁶⁵	10.67	CD34 KIT THBD

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GO Terms for Senile Angioma

Cellular components related to Senile Angioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	9.26	CD34 KIT TF THBD
2	basal plasma membrane	GO:0009925	9.16	CD34 TF
3	endocytic vesicle lumen	GO:0071682	8.62	HBA1 HSP90AA1

Biological processes related to Senile Angioma according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	protein phosphorylation	GO:0006468	9.81	CCNE1 KDR KIT MAP2K1
2	negative regulation of gene expression	GO:0010629	9.67	CD34 KDR MAP2K1
3	positive regulation of gene expression	GO:0010628	9.67	CD34 KIT MAP2K1 VIM
4	ERK1 and ERK2 cascade	GO:0070371	9.48	KDR MAP2K1
5	cell motility	GO:0048870	9.46	CD34 MAP2K1
6	embryonic hemopoiesis	GO:0035162	9.43	KDR KIT
7	negative regulation of blood coagulation	GO:0030195	9.4	CD34 THBD
8	regulation of cellular protein localization	GO:1903827	9.32	CCNE1 HSP90AA1
9	positive regulation of vasculogenesis	GO:2001214	9.26	CD34 KDR
10	Bergmann glial cell differentiation	GO:0060020	9.16	MAP2K1 VIM
11	endothelium development	GO:0003158	8.96	CD34 KDR
12	peptidyl-tyrosine phosphorylation	GO:0018108	8.92	HSP90AA1 KDR KIT MAP2K1

Molecular functions related to Senile Angioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity	GO:0004716	9.16	KDR KIT
2	scaffold protein binding	GO:0097110	9.13	HSP90AA1 MAP2K1 VIM
3	protein tyrosine kinase activity	GO:0004713	8.92	HSP90AA1 KDR KIT MAP2K1

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Sources for Senile Angioma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia