MCID: SNL003
MIFTS: 35

Senile Angioma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Senile Angioma

MalaCards integrated aliases for Senile Angioma:

Name: Senile Angioma 12 15 73
Senile Naevus of Skin 12
Senile Hemangioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2495
NCIt 50 C4390
SNOMED-CT 68 11790000 5050001
UMLS 73 C0343082

Summaries for Senile Angioma

MalaCards based summary : Senile Angioma, also known as senile naevus of skin, is related to mast-cell sarcoma and malignant mixed mullerian tumor. An important gene associated with Senile Angioma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and Endometrial cancer. The drugs Octreotide and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include skin, b cells and endothelial, and related phenotypes are Reduced mammosphere formation and cellular

Related Diseases for Senile Angioma

Diseases related to Senile Angioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 mast-cell sarcoma 10.8 KIT VIM
2 malignant mixed mullerian tumor 10.8 KIT VIM
3 benign breast phyllodes tumor 10.8 KIT VIM
4 perivascular epithelioid cell tumor 10.7 KIT VIM
5 ovarian melanoma 10.7 KIT MAP2K1
6 perineurioma 10.7 KIT VIM
7 pulmonary vein stenosis 10.7 KDR KIT
8 dermoid cyst 10.7 KIT VIM
9 embryonal sarcoma 10.6 KIT VIM
10 smooth muscle tumor 10.6 KIT VIM
11 rete testis adenocarcinoma 10.6 KIT THBD
12 gallbladder leiomyoma 10.6 CD34 KIT
13 lung leiomyosarcoma 10.6 CD34 KIT
14 adenomatoid tumor 10.6 THBD VIM
15 liver leiomyoma 10.6 CD34 KIT
16 8p11 myeloproliferative syndrome 10.6 KDR KIT
17 deep leiomyoma 10.6 CD34 KIT
18 extracutaneous mastocytoma 10.6 CD34 KIT
19 polymorphous low-grade adenocarcinoma 10.5 KIT VIM
20 rete testis neoplasm 10.5 KIT THBD
21 small intestine leiomyosarcoma 10.5 CD34 KIT
22 small intestinal sarcoma 10.5 CD34 KIT
23 glomangiomyoma 10.5 CD34 VIM
24 gallbladder sarcoma 10.5 CD34 KIT
25 prostate leiomyosarcoma 10.5 CD34 KIT
26 sternum cancer 10.5 CD34 VIM
27 diffuse cutaneous mastocytosis 10.5 CD34 KIT
28 sarcomatoid squamous cell skin carcinoma 10.5 CD34 KIT
29 adenoid squamous cell carcinoma 10.5 HBA1 VIM
30 gastric leiomyosarcoma 10.5 CD34 KIT
31 plexiform schwannoma 10.5 CD34 KIT
32 conventional fibrosarcoma 10.5 CD34 KIT
33 cavernous hemangioma 10.4 KDR KIT VIM
34 mast-cell leukemia 10.4 KDR KIT
35 angiosarcoma 10.4 KDR KIT VIM
36 kaposiform hemangioendothelioma 10.4 CD34 KDR
37 capillary hemangioma 10.4 HBA1 KDR
38 skin hemangioma 10.4 HBA1 KDR
39 hemangiopericytoma, malignant 10.3 HBA1 VIM
40 ovary sarcoma 10.3 CD34 HBA1
41 ovarian angiosarcoma 10.3 CD34 HBA1
42 intravascular fasciitis 10.3 CD34 HBA1
43 pediatric angiosarcoma 10.3 CD34 HBA1
44 thyroid angiosarcoma 10.3 CD34 HBA1
45 benign mesothelioma 10.3 THBD VIM
46 neurogenic arthropathy 10.3 CD34 HBA1
47 malignant dermis tumor 10.3 HBA1 KIT
48 spleen angiosarcoma 10.3 CD34 HBA1
49 bone epithelioid hemangioma 10.3 CD34 HBA1
50 thyroid sarcoma 10.3 CD34 HBA1

Graphical network of the top 20 diseases related to Senile Angioma:



Diseases related to Senile Angioma

Symptoms & Phenotypes for Senile Angioma

GenomeRNAi Phenotypes related to Senile Angioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 CCNE1 CD34 HSP90AA1 KDR VIM

MGI Mouse Phenotypes related to Senile Angioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.76 CCNE1 CD34 HSP90AA1 KDR KIT MAP2K1
2 embryo MP:0005380 9.43 CCNE1 KDR KIT MAP2K1 THBD VIM
3 integument MP:0010771 9.1 CCNE1 CD34 KDR KIT MAP2K1 THBD

Drugs & Therapeutics for Senile Angioma

Drugs for Senile Angioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
2
Somatostatin Approved, Investigational Phase 2 38916-34-6, 51110-01-1 53481605
3 Antineoplastic Agents, Hormonal Phase 2
4 Gastrointestinal Agents Phase 2
5 Hormones Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Pilot Study of Octreotide, a Somatostatin Octapeptide Analog, for Gastrointestinal Hemorrhage in Hormone-Refractory Hereditary Hemorrhagic Telangiectasia and Senile Ectasia Completed NCT00004327 Phase 2 octreotide
2 Comparison of Electrodessication, Potassium Titanyl Phosphate (KTP) Laser and Pulsed Dye Laser for Treatment of Cherry Angiomata Completed NCT00791908 Not Applicable

Search NIH Clinical Center for Senile Angioma

Genetic Tests for Senile Angioma

Anatomical Context for Senile Angioma

MalaCards organs/tissues related to Senile Angioma:

41
Skin, B Cells, Endothelial

Publications for Senile Angioma

Articles related to Senile Angioma:

# Title Authors Year
1
Intravascular large B cell lymphoma with neurological symptoms diagnosed on the basis of a senile angioma-like eruption. ( 21686374 )
2009
2
Prichard's structures of the fossa ovalis are age-related phenomena composed of nonreplicating endothelial cells: the cardiac equivalent of cutaneous senile angioma. ( 18092955 )
2007
3
Senile angioma-like eruption: a skin manifestation of intravascular large B cell lymphoma. ( 15316168 )
2004
4
Intravascular large B cell lymphoma diagnosed by senile angioma biopsy. ( 12583632 )
2003
5
[Clinical features and histology of angioma. III. Histology and pathogenesis of senile angioma]. ( 13198143 )
1954

Variations for Senile Angioma

Expression for Senile Angioma

Search GEO for disease gene expression data for Senile Angioma.

Pathways for Senile Angioma

Pathways related to Senile Angioma according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 HSP90AA1 KDR KIT MAP2K1 VIM
2
Show member pathways
12.5 CCNE1 HSP90AA1 KIT MAP2K1
3 12.43 CCNE1 HSP90AA1 KIT MAP2K1
4
Show member pathways
12.18 CCNE1 HSP90AA1 KDR KIT MAP2K1
5
Show member pathways
12.16 HSP90AA1 KDR MAP2K1 TF
6
Show member pathways
12.02 CCNE1 HSP90AA1 MAP2K1
7 11.69 HSP90AA1 KDR THBD
8 11.4 HSP90AA1 IVL MAP2K1
9
Show member pathways
11.25 KDR KIT MAP2K1
10 11.01 IVL THBD
11 10.67 CD34 KIT THBD

GO Terms for Senile Angioma

Cellular components related to Senile Angioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 CD34 KIT TF THBD
2 basal plasma membrane GO:0009925 9.16 CD34 TF
3 endocytic vesicle lumen GO:0071682 8.62 HBA1 HSP90AA1

Biological processes related to Senile Angioma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.81 CCNE1 KDR KIT MAP2K1
2 negative regulation of gene expression GO:0010629 9.67 CD34 KDR MAP2K1
3 positive regulation of gene expression GO:0010628 9.67 CD34 KIT MAP2K1 VIM
4 ERK1 and ERK2 cascade GO:0070371 9.48 KDR MAP2K1
5 cell motility GO:0048870 9.46 CD34 MAP2K1
6 embryonic hemopoiesis GO:0035162 9.43 KDR KIT
7 negative regulation of blood coagulation GO:0030195 9.4 CD34 THBD
8 regulation of cellular protein localization GO:1903827 9.32 CCNE1 HSP90AA1
9 positive regulation of vasculogenesis GO:2001214 9.26 CD34 KDR
10 Bergmann glial cell differentiation GO:0060020 9.16 MAP2K1 VIM
11 endothelium development GO:0003158 8.96 CD34 KDR
12 peptidyl-tyrosine phosphorylation GO:0018108 8.92 HSP90AA1 KDR KIT MAP2K1

Molecular functions related to Senile Angioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.16 KDR KIT
2 scaffold protein binding GO:0097110 9.13 HSP90AA1 MAP2K1 VIM
3 protein tyrosine kinase activity GO:0004713 8.92 HSP90AA1 KDR KIT MAP2K1

Sources for Senile Angioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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