Senile Angioma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Senile Angioma

MalaCards integrated aliases for Senile Angioma:

Name: Senile Angioma ¹² ¹⁵ ⁷⁰

Senile Naevus of Skin ¹²

Senile Hemangioma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2495

NCIt ⁵⁰ C4390

SNOMED-CT ⁶⁷ 5050001

UMLS ⁷⁰ C0343082

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Summaries for Senile Angioma

MalaCards based summary : Senile Angioma, also known as senile naevus of skin, is related to hemangioma and testicular gonadoblastoma. An important gene associated with Senile Angioma is MIR424 (MicroRNA 424), and among its related pathways/superpathways are Gastric cancer and MicroRNAs in cancer. Affiliated tissues include skin and endothelial.

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Related Diseases for Senile Angioma

Diseases related to Senile Angioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)

#	Related Disease	Score	Top Affiliating Genes
1	hemangioma	29.6	VIM MAP2K1 KIT
2	testicular gonadoblastoma	10.2	VIM KIT
3	liver fibroma	10.2	VIM KIT
4	esophageal adenoid cystic carcinoma	10.2	VIM KIT
5	vaginal endometrial stromal sarcoma	10.2	VIM KIT
6	mast-cell sarcoma	10.2	VIM KIT
7	vagina sarcoma	10.2	VIM KIT
8	benign breast phyllodes tumor	10.2	VIM KIT
9	bladder leiomyoma	10.2	VIM KIT
10	embryonal sarcoma	10.2	VIM KIT
11	b-cell lymphoma	10.2
12	intravascular large b-cell lymphoma	10.2
13	polymorphous low-grade adenocarcinoma	10.2	VIM KIT
14	acral lentiginous melanoma	10.1	VIM KIT
15	pleomorphic liposarcoma	10.1	VIM KIT
16	adenosarcoma	10.1	VIM KIT
17	perineurioma	10.1	VIM KIT
18	perivascular epithelioid cell tumor	10.1	VIM KIT
19	pseudosarcomatous fibromatosis	10.1	VIM KIT
20	nephroma	10.1	VIM KIT
21	hemangiopericytoma, malignant	10.1	VIM KIT
22	smooth muscle tumor	10.1	VIM KIT
23	renal oncocytoma	10.1	VIM KIT
24	oncocytoma	10.1	VIM KIT
25	cavernous hemangioma	10.1	VIM KIT
26	angiomyolipoma	10.1	VIM KIT
27	mucinous adenocarcinoma	10.1	VIM KIT
28	fibrous histiocytoma	10.1	VIM KIT
29	neurilemmoma	10.1	VIM KIT
30	neurofibroma	10.1	VIM KIT
31	carcinosarcoma	10.0	VIM KIT
32	angiosarcoma	10.0	VIM KIT
33	prostate squamous cell carcinoma	10.0	MAP2K1 CCNE1
34	inflammatory myofibroblastic tumor	9.9	VIM KIT
35	diffuse large b-cell lymphoma	9.9
36	capillary hemangioma	9.9
37	spasticity	9.9
38	spindle cell sarcoma	9.9	VIM KIT CCNE1
39	dermatofibrosarcoma protuberans	9.9	VIM KIT
40	oropharynx cancer	9.9	MIR455 KIT
41	pancytopenia	9.9
42	endometrial serous adenocarcinoma	9.8	MIR455 CCNE1
43	fibrosarcoma	9.8	VIM MAP2K1 KIT
44	pheochromocytoma	9.7	VIM MAP2K1 KIT
45	nervous system disease	9.5	MIRLET7F1 MIR455 MIR424
46	lymphoma, non-hodgkin, familial	9.4	MIR455 MIR424 MAP2K1
47	leukemia, acute myeloid	9.3	MIR455 MIR424 MAP2K1 KIT
48	skin disease	9.3	VIM MIR455 KIT
49	ovarian cancer	9.2	VIM MIR424 MAP2K1 KIT CCNE1

Graphical network of the top 20 diseases related to Senile Angioma:

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Symptoms & Phenotypes for Senile Angioma

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Drugs & Therapeutics for Senile Angioma

Search Clinical Trials , NIH Clinical Center for Senile Angioma

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Genetic Tests for Senile Angioma

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Anatomical Context for Senile Angioma

MalaCards organs/tissues related to Senile Angioma:

⁴⁰

Skin, Endothelial

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Publications for Senile Angioma

Articles related to Senile Angioma:

(show all 12)

#	Title	Authors	PMID	Year
1	Skin tumors in xeroderma pigmentosum: Evaluation of a large series and a literature review. ⁶¹	Baykal C...Buyukbabani N	33569789	2021
2	Treatment Modalities for Cherry Angiomas: A Systematic Review. ⁶¹	Buslach N...Mesinkovska NA	33252464	2020
3	Inhibition of heat shock protein 90 exerts an antitumour effect in angiosarcoma: involvement of the vascular endothelial growth factor signalling pathway. ⁶¹	Yamada-Kanazawa S...Ihn H	28078663	2017
4	Intravascular large B cell lymphoma with neurological symptoms diagnosed on the basis of a senile angioma-like eruption. ⁶¹	Nakamura Y...Tamaoka A	21686374	2009
5	Prichard's structures of the fossa ovalis are age-related phenomena composed of nonreplicating endothelial cells: the cardiac equivalent of cutaneous senile angioma. ⁶¹	Val-Bernal JF...Garijo MF	18092955	2007
6	Senile angioma-like eruption: a skin manifestation of intravascular large B cell lymphoma. ⁶¹	Motegi S...Ishikawa O	15316168	2004
7	Intravascular large B cell lymphoma diagnosed by senile angioma biopsy. ⁶¹	Satoh S...Hachyou M	12583632	2003
8	[Various histological findings in the so-called senile angioma. Phenomenon of the epidermo-dermal surveillance]. ⁶¹	Salamon T...Milicecic M	4592041	1973
9	[Clinical picture and histology of so-called senile angioma of the free lip edges (Pasini)]. ⁶¹	KELLER R	13671883	1959
10	[Senile angioma]. ⁶¹	ROMAGUERA LLACH C	13533048	1958
11	[Clinical features and histology of angioma. III. Histology and pathogenesis of senile angioma]. ⁶¹	SCHNYDER UW...KELLER R	13198143	1954
12	[On incidence by age of disseminated papuliferous teleangiectases so-called senile angioma]. ⁶¹	WAGNER G	13039348	1953

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Genes for Senile Angioma

Genes related to Senile Angioma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MIR424	MicroRNA 424	RNA Gene	12.74	DISEASES inferred ¹⁵ ¹⁵
2	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	10.68	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	VIM	Vimentin	Protein Coding	7	GeneCards inferred via : Publications (show sections)
4	CCNE1	Cyclin E1	Protein Coding	6.18	DISEASES inferred ¹⁵
5	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	5.69	DISEASES inferred ¹⁵
6	MIR455	MicroRNA 455	RNA Gene	5.11	DISEASES inferred ¹⁵
7	MIRLET7F1	MicroRNA Let-7f-1	RNA Gene	4.99	DISEASES inferred ¹⁵

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Variations for Senile Angioma

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Expression for Senile Angioma

Search GEO for disease gene expression data for Senile Angioma.

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Pathways for Senile Angioma

Pathways related to Senile Angioma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.21	MAP2K1 KIT CCNE1
2	MicroRNAs in cancer ³⁶	11.42	VIM MIRLET7F1 MAP2K1 CCNE1
3	VEGF Pathway (Tocris) ⁶⁹ Show member pathways Sorafenib Pharmacodynamics ⁶⁰	11.32	MAP2K1 KIT
4	Central carbon metabolism in cancer ³⁶	11.17	MAP2K1 KIT
5	Human Thyroid Stimulating Hormone (TSH) signaling pathway ¹	11.09	MAP2K1 CCNE1
6	mTOR signaling pathway (Pathway Interaction Database) ¹	10.93	MAP2K1 CCNE1
7	miRNAs involved in DNA damage response ¹	10.65	MIRLET7F1 CCNE1

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GO Terms for Senile Angioma

Biological processes related to Senile Angioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Bergmann glial cell differentiation	GO:0060020	8.62	VIM MAP2K1

Molecular functions related to Senile Angioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	scaffold protein binding	GO:0097110	8.96	VIM MAP2K1
2	mRNA binding involved in posttranscriptional gene silencing	GO:1903231	8.8	MIRLET7F1 MIR455 MIR424

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Sources for Senile Angioma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

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¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia