MCID: SNL007
MIFTS: 42

Senile Cataract

Categories: Eye diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Senile Cataract

MalaCards integrated aliases for Senile Cataract:

Name: Senile Cataract 12 54 15 32

Classifications:



External Ids:

Disease Ontology 12 DOID:9669
ICD9CM 34 366.1
NCIt 49 C35012
SNOMED-CT 67 39450006
ICD10 32 H25 H25.9
UMLS 71 C0036646

Summaries for Senile Cataract

Disease Ontology : 12 A cataract that is characterized by thickening and loss of transparency of the lens with age progression, caused by a multifactorial etiology related to aging.

MalaCards based summary : Senile Cataract is related to mature cataract and morgagni cataract. An important gene associated with Senile Cataract is CRYAA (Crystallin Alpha A), and among its related pathways/superpathways are Glucose / Energy Metabolism and Folate Metabolism. The drugs Ketorolac and Nepafenac have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and testes, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Senile Cataract

Diseases related to Senile Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 mature cataract 32.6 LAMA3 CRYGS CRYAA
2 morgagni cataract 32.0 LAMA3 CRYGS CRYAA
3 macular retinal edema 30.5 SERPINF1 CRYAA ALB
4 microvascular complications of diabetes 5 30.4 SOD1 SERPINF1 CRYAA ALB
5 retinal vascular disease 30.0 SERPINF1 CRYAA ALB
6 lens subluxation 29.5 LAMA3 CRYAA BFSP1
7 diabetic cataract 29.3 SERPINF1 GSR G6PD CRYGS CRYAA CAT
8 macular degeneration, age-related, 1 29.2 SERPINF1 LAMA3 CRYAA CAT ALB
9 presbyopia 28.9 LAMA3 CRYGS CRYAA BFSP1
10 cataract 27.4 XRCC1 WRN TKT TALDO1 SOD1 SERPINF1
11 nuclear senile cataract 12.8
12 cortical senile cataract 12.7
13 immature cataract 12.3
14 intraocular pressure quantitative trait locus 10.5
15 hearing loss, noise-induced 10.5 GSTT1 GSTM1
16 colorectal cancer 8 10.5 GSTT1 GSTM1
17 congenital methemoglobinemia 10.4 SOD1 G6PD
18 isolated cleft lip 10.4 GSTT1 GSTM1
19 yemenite deaf-blind hypopigmentation syndrome 10.4
20 trimethoprim allergy 10.4 GSTM1 GSR G6PD
21 sister chromatid exchange, frequency of 10.4 XRCC1 GSTT1 GSTM1
22 meningococcal infection 10.3 SOD1 GSR G6PD
23 mutagen sensitivity 10.3 XRCC1 GSTT1 GSTM1
24 lymphosarcoma 10.3 GSR G6PD
25 cardia cancer 10.3 XRCC1 GSTT1 GSTM1
26 methemoglobinemia 10.3 SOD1 GSR G6PD
27 joint laxity, short stature, and myopia 10.3
28 myopia 10.3
29 drug-induced hepatitis 10.3 GSTT1 GSTM1 ALB
30 early-onset nuclear cataract 10.3 EPHA2 CRYAA BFSP1
31 eales disease 10.2 SOD1 SERPINF1
32 plasmodium falciparum malaria 10.2 GSR G6PD ALB
33 astigmatism 10.2
34 open-angle glaucoma 10.2
35 diabetes mellitus 10.2
36 carbohydrate metabolic disorder 10.2 GALK1 G6PD CRYAA
37 critical illness polyneuropathy 10.2 CS ALB
38 transaldolase deficiency 10.2 TKT TALDO1
39 cataract 6, multiple types 10.2 EPHA2 CRYAA
40 inflammatory and toxic neuropathy 10.1 TKT ALB
41 strabismus 10.1
42 aging 10.1
43 microvascular complications of diabetes 1 10.1
44 microvascular complications of diabetes 2 10.1
45 uveitis 10.1
46 glucosephosphate dehydrogenase deficiency 10.1
47 eye disease 10.1
48 mechanical strabismus 10.1
49 hyperphenylalaninemia 10.1 SOD1 G6PD CAT
50 early-onset lamellar cataract 10.1 CRYGS CRYAA

Graphical network of the top 20 diseases related to Senile Cataract:



Diseases related to Senile Cataract

Symptoms & Phenotypes for Senile Cataract

GenomeRNAi Phenotypes related to Senile Cataract according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-2 9.68 EPHA2 GALK1 SOD1
2 Decreased viability GR00221-A-3 9.68 EPHA2 SOD1
3 Decreased viability GR00221-A-4 9.68 EPHA2 SOD1
4 Decreased viability GR00240-S-1 9.68 GALK1
5 Decreased viability GR00249-S 9.68 ALB CRYAA G6PD GSR GSTM1 SOD1
6 Decreased viability GR00381-A-1 9.68 GSTM1 SERPINF1
7 Decreased viability GR00386-A-1 9.68 ALB G6PD GSTM1
8 Decreased viability GR00402-S-2 9.68 CRYAA G6PD OGG1

MGI Mouse Phenotypes related to Senile Cataract:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.5 ALB CAT EPHA2 OGG1 SOD1 WRN
2 vision/eye MP:0005391 9.28 BFSP1 CRYGS EPHA2 GALK1 GSR SERPINF1

Drugs & Therapeutics for Senile Cataract

Drugs for Senile Cataract (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
2
Nepafenac Approved, Investigational Phase 4 78281-72-8 151075
3
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
4
Bromfenac Approved Phase 4 91714-94-2 60726
5 Polymethyl Methacrylate Phase 4
6 Vasodilator Agents Phase 4
7 Ketorolac Tromethamine Phase 4
8 Cyclooxygenase Inhibitors Phase 4
9 Analgesics, Non-Narcotic Phase 4
10 Adjuvants, Immunologic Phase 4
11 Viscosupplements Phase 4
12 Analgesics Phase 4
13 Protective Agents Phase 4
14 Anti-Inflammatory Agents Phase 4
15 Immunologic Factors Phase 4
16 Antirheumatic Agents Phase 4
17 Anti-Inflammatory Agents, Non-Steroidal Phase 4
18
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
19
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
20
Dipivefrin Approved 52365-63-6 3105
21
Lidocaine Approved, Vet_approved 137-58-6 3676
22
Phenylephrine Approved 59-42-7 6041
23
Iodine Approved, Investigational 7553-56-2 807
24
Oxymetazoline Approved, Investigational 1491-59-4 4636
25
Povidone Approved 9003-39-8
26
Tropicamide Approved, Investigational 1508-75-4 5593
27
Povidone-iodine Approved 25655-41-8
28 Hormones
29 Antineoplastic Agents, Hormonal
30 Antiemetics
31 Hormone Antagonists
32 glucocorticoids
33 Gastrointestinal Agents
34 Goji
35 Lycium
36
Chondroitin 9007-27-6 53477707
37 cadexomer iodine
38 Anesthetics

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Posterior Capsule Opacification After Implantation of Square Edge PMMA, Round Edge PMMA and Acrysof Intraocular Lenses: Randomized Controlled Study Completed NCT00312299 Phase 4
2 Comparison of Ketorolac Tromethamine 0.4% and Nepafenac 0.1% for the Prevention of Cystoid Macular Edema After Phacoemulsification: Prospective Randomized Double-masked Study Completed NCT02084576 Phase 4 Nepafenac;Ketorolac
3 Topical 0,09% Bromfenac for Intraoperative Miosis and Pain Reduction in Femtosecond Laser-assisted Cataract Surgery Enrolling by invitation NCT03831984 Phase 4 0,09% Bromfenac;0,1% sodium hyaluronate
4 Clinical Evaluation of the Aspheric SeeLens AF Intra-Ocular Lens. Unknown status NCT00825747 Phase 3
5 Standard Coaxial Microincision Cataract Surgery Versus Coaxial Microincision Cataract Surgery Using 1% Ultrasound in Immature Senile Cataract :a Corneal Endothelium Study Unknown status NCT01259349 Phase 3
6 The Efficiency of a New Device for Performing Capsulorhexis in Cataract Surgery Unknown status NCT01396967 Phase 1
7 To Investigate Tear Film Change After Phacoemulsification With SS-OCT Unknown status NCT02238015
8 Corneal Endothelial Cell Loss After Phacoemulsification Compared With Extracapsular Cataract Extraction in Management of Senile Cataract Unknown status NCT03262285
9 An Investigator-Initiated Trials on the Efficacy and Stability of AT TORBI 709M 4-haptic Toric IOL in Cataract Surgery Unknown status NCT02618018
10 Safety and Efficacy of Implantation of Two Multifocal Intraocular Lenses in the Treatment of Senile Cataract: a Randomized Controlled Clinical Trial Unknown status NCT02966496
11 Neural Compensation, Visual Function and Visual Quality in Senile Cataract Patients After Monofocal or Multifocal Intraocular Lens Implantation Unknown status NCT02644720 Dexamethasone
12 Effects of Lycium Barbarum Supplements on the Progression of Senile Cataract in Hong Kong Chinese Population Completed NCT01142960
13 Prospective Evaluation of Posterior Capsule Opacification in Myopic Eyes 4 Years After AcrySof Single-Piece IOL Implantation Completed NCT00855491
14 A Twelve-Months, Single-Masked, Parallel Group, Health Economic Study of Phacoemulsification Versus Small Incision Cataract Surgery (SICS) in Chinese Patients With Senile Cataract. Completed NCT00762606
15 The Impact of Visual Axis Position on the Optical Quality After Implantation of Multifocal Intraocular Lenses With Different Asphericity Values Completed NCT04274088
16 Surgically Induced Astigmatism of Temporal Versus Nasal Clear Corneal Phacoemulsification Completed NCT00521833
17 Liquefaction Versus Torsional ip. A Comparative Study on Endothelial Cells, Corneal Edema and Corneal Sensitivity Completed NCT01480557
18 Rotational Stability of the Acrysof, Tecnis and Envista Intraocular Lenses Completed NCT04345380
19 Viscoat Versus Visthesia. A Comparative Study of Post-cataract Endothelial Cell Loss Completed NCT02304861
20 Randomized, Controlled Trial in Patients With Senile Cataract to Evaluate the Efficacy of Ultrasound-free Femtosecond Laser (FLACS) Cataract Surgery (USFREE), Compared to Traditional Phacoemulsification Surgery Using Ultrasound. Completed NCT03050008
21 Refractive Outcome and Optimization of IOL-Constants After Implantation of the Precisight® Intraocular Lens. Active, not recruiting NCT02970487
22 An Epidemiological Observational Study for Retrospective and Prospective Evaluation of for the Prevalence of Cerebrotendinous Xanthomatosis (CTX) Disease in Neurology and Pediatric Metabolism Clinics in Turkey Not yet recruiting NCT04113083
23 Subclinical Sympathetic Response Related to Second-eye Pain in Cataract Surgery and Its Noninvasive Detection Index Not yet recruiting NCT03766230

Search NIH Clinical Center for Senile Cataract

Genetic Tests for Senile Cataract

Anatomical Context for Senile Cataract

MalaCards organs/tissues related to Senile Cataract:

40
Eye, Endothelial, Testes, Retina, Salivary Gland, Skin, Brain

Publications for Senile Cataract

Articles related to Senile Cataract:

(show top 50) (show all 1321)
# Title Authors PMID Year
1
Glucose-6-phosphate dehydrogenase (G6PD) deficiency and senile cataract in a Sardinian male population, Italy. 54 61
19995205 2009
2
The evaluation of the oxidative stress parameters in nondiabetic and diabetic senile cataract patients. 54 61
18982249 2009
3
Implication of glutathione S-transferase M1 and T1 polymorphisms in the development of senile cataract among Egyptians. 54 61
20120433 2009
4
Activity of superoxide dismutase obtained from senile cataract lens - effect of diabetes mellitus. 54 61
19093039 2008
5
Role of anti-oxidant enzymes superoxide dismutase and catalase in the development of cataract : study of serum levels in patients with senile and diabetic cataracts. 61 54
17240813 2006
6
Decreased glucose-6-phosphate-dehydrogenase (G6PD) activity and risk of senile cataract in Taiwan. 54 61
16581614 2006
7
Erythrocyte antioxidant enzymes in patients with cataract. 54 61
16682518 2006
8
Downregulation of gene expression in the ageing lens: a possible contributory factor in senile cataract. 61 54
15105821 2005
9
Changes in glutathione, glutathione-linked enzymes and hexose monophosphate shunt enzymes in senile cataract. 61 54
15255623 2003
10
[The study on superoxide dismutase and trace element in patients with senile cataract]. 54 61
12579780 2000
11
Polymorphic glutathione S-transferases as genetic risk factors for senile cortical cataract in Estonians. 54 61
10892871 2000
12
[Relationship between GSTM1 genotype and susceptibility to senile cataract]. 54 61
11835784 1999
13
The study of G6PD in erythrocyte and lens in senile and presenile cataract. 61 54
1286674 1992
14
Senile cataract and glucose-6-phosphate dehydrogenase deficiency in Indians. 61 54
2100077 1990
15
Long-Lasting Thrombocytopenia and Senile Cataract. 61
32542376 2020
16
Comparison of inflammatory cytokines levels in the aqueous humor with diabetic retinopathy. 61
32556740 2020
17
Phacoemulsification Induced Changes of Choroidal Thickness in Eyes with Age-Related Macular Degeneration. 61
32455884 2020
18
Lens epithelial surface disorders in exfoliation syndrome: a scanning and transmission electron microscopy study. 61
32403107 2020
19
Nutrition knowledge and dietary patterns in ophthalmic patients. 61
32363741 2020
20
Posterior capsule opacification and Nd:YAG laser rates with two hydrophobic acrylic single-piece IOLs. 61
31485039 2020
21
Comparative clinical trial of intracameral ropivacaine vs. lignocaine in subjects undergoing phacoemulsification under augmented topical anesthesia. 61
32174572 2020
22
Ease of hydrodissection during phacoemulsification: a comparison between patients with and without exfoliation syndrome. 61
32163946 2020
23
Frequency of Corneal Astigmatism in Patients Presenting for Senile Cataract Surgery at a Teaching Hospital in Indian Rural Population. 61
31923034 2020
24
Prevalence of diabetes and diabetic macular edema in patients undergoing senile cataract surgery in Italy: The DIabetes and CATaract study. 61
30854895 2020
25
Pigment epithelial-derived factor in the lens anterior capsule of patients with senile cataract with pseudoexfoliation. 61
31090113 2020
26
Is Dietary Milk Intake Associated with Cataract Extraction History in Older Adults? An Analysis from the US Population. 61
32148937 2020
27
A Preliminary Comparative Study of Visual Performance Between Two Newly Commercially Available Monofocal Intraocular Lenses Implanted During Cataract Surgery. 61
32214794 2020
28
Aqueous humor and serum 25-Hydroxyvitamin D levels in patients with cataracts. 61
31906919 2020
29
Characteristic Cytokine Profiles of Aqueous Humor in Glaucoma Secondary to Sturge-Weber Syndrome. 61
32117217 2020
30
Social impact indicators in patient diagnosed of senile cataract treated with phacoemulsification plus intraocular lens implantation. 61
32538985 2020
31
Aqueous cytokine levels in four common uveitis entities. 61
31776091 2020
32
Evaluation of Barrett universal II formula for intraocular lens power calculation in Asian Indian population. 61
31856468 2020
33
Higher aqueous levels of matrix metalloproteinases indicated visual impairment in patients with retina vein occlusion after anti-VEGF therapy. 61
31843793 2019
34
Comorbidity of keratoconus and Fuchs' corneal endothelial dystrophy: a review of the literature. 61
31865313 2019
35
Carnosine Prevents Different Structural Damages Induced by Methylglyoxal in Lens Crystallins. 61
31535344 2019
36
A comparative study of stereoacuity in patients with various grades of cataract and bilateral pseudophakia. 61
31638044 2019
37
Possible therapeutic effect of magnesium in ocular diseases. 61
31730524 2019
38
The efficacy of "IOL-Vip Revolution" telescopic intraocular lens in age-related macular degeneration cases with senile cataract. 61
30280594 2019
39
Association of LOXL1 Gene Polymorphisms with Exfoliation Glaucoma Patients. 61
31850260 2019
40
Abnormal levels of aqueous humor trace elements in patients with cytomegalovirus retinitis. 61
31065104 2019
41
Sequelae of neglected hypermature senile cataract. 61
31546522 2019
42
Metabolic characterization of diabetic retinopathy: An 1H-NMR-based metabolomic approach using human aqueous humor. 61
31212142 2019
43
Rare atypical presentation of phacolytic glaucoma as non-resolving microbial keratitis with endophthalmitis. 61
31527222 2019
44
Comparison of effective phacoemulsification time and corneal endothelial cell loss using 2 ultrasound frequencies. 61
31371150 2019
45
A comparison of posterior capsular opacification after implantation of three different hydrophobic square edge intraocular lenses. 61
31436185 2019
46
An in vivo confocal microscopy study of corneal changes in pseudoexfoliation syndrome. 61
30280588 2019
47
MYH9-related disorders display heterogeneous kidney involvement and outcome. 61
31384440 2019
48
Increased Aqueous Humor Symmetric Dimethylarginine Level in Patients with Primary Open Angle Glaucoma. 61
30707048 2019
49
Changes in ocular surface status after phacoemulsification in patients with senile cataract. 61
29926365 2019
50
Changes in subfoveal choroidal thickness after uncomplicated cataract surgery. 61
30565567 2019

Variations for Senile Cataract

Expression for Senile Cataract

Search GEO for disease gene expression data for Senile Cataract.

Pathways for Senile Cataract

Pathways related to Senile Cataract according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1 12.27 TKT G6PD CS CAT
2
Show member pathways
12.07 SOD1 GSR CAT ALB
3
Show member pathways
12.01 GSTT1 GSTM1 GSR G6PD
4 11.72 GSTM1 GSR G6PD EPHA2
5
Show member pathways
11.35 TKT TALDO1 G6PD CS CAT
6
Show member pathways
11.34 TKT TALDO1 G6PD
7
Show member pathways
11.24 SOD1 GSR CAT
8 10.82 SOD1 GSR CAT
9 10.75 GSR G6PD
10 10.66 TALDO1 G6PD
11 10.59 SOD1 GSTT1 GSTM1

GO Terms for Senile Cataract

Cellular components related to Senile Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.4 TKT TALDO1 SOD1 SERPINF1 LAMA3 GSTT1

Biological processes related to Senile Cataract according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.92 SOD1 OGG1 CRYAA CAT ALB
2 response to drug GO:0042493 9.85 XRCC1 SOD1 OGG1 CAT
3 carbohydrate metabolic process GO:0005975 9.81 TALDO1 GALK1 G6PD CS
4 response to oxidative stress GO:0006979 9.78 WRN SOD1 OGG1 CAT
5 response to ethanol GO:0045471 9.73 SOD1 OGG1 G6PD CAT
6 base-excision repair GO:0006284 9.63 XRCC1 WRN OGG1
7 cellular response to oxidative stress GO:0034599 9.62 SOD1 GSR G6PD CAT
8 cellular oxidant detoxification GO:0098869 9.56 GSTT1 GSR CAT ALB
9 aging GO:0007568 9.55 WRN SOD1 SERPINF1 OGG1 CAT
10 response to reactive oxygen species GO:0000302 9.54 SOD1 CAT
11 pentose-phosphate shunt, non-oxidative branch GO:0009052 9.49 TKT TALDO1
12 ribose phosphate biosynthetic process GO:0046390 9.4 TKT G6PD
13 xylulose biosynthetic process GO:0005999 9.37 TKT TALDO1
14 pentose-phosphate shunt GO:0006098 9.13 TKT TALDO1 G6PD
15 glutathione metabolic process GO:0006749 9.02 SOD1 GSTT1 GSTM1 GSR G6PD

Molecular functions related to Senile Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 9.33 GSR G6PD CAT
2 antioxidant activity GO:0016209 9.13 SOD1 CAT ALB
3 structural constituent of eye lens GO:0005212 8.8 CRYGS CRYAA BFSP1

Sources for Senile Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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