MCID: SNL007
MIFTS: 42

Senile Cataract

Categories: Eye diseases, Genetic diseases

Aliases & Classifications for Senile Cataract

MalaCards integrated aliases for Senile Cataract:

Name: Senile Cataract 12 54 15 32

Classifications:



External Ids:

Disease Ontology 12 DOID:9669
ICD9CM 34 366.1 366.10
NCIt 49 C35012
SNOMED-CT 67 39450006
ICD10 32 H25 H25.9
UMLS 71 C0036646

Summaries for Senile Cataract

Disease Ontology : 12 A cataract that is characterized by thickening and loss of transparency of the lens with age progression, caused by a multifactorial etiology related to aging.

MalaCards based summary : Senile Cataract is related to mature cataract and microvascular complications of diabetes 5. An important gene associated with Senile Cataract is CRYAA (Crystallin Alpha A), and among its related pathways/superpathways are Glucose / Energy Metabolism and Folate Metabolism. The drugs Ketorolac and Nepafenac have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and testes, and related phenotypes are cardiovascular system and neoplasm

Related Diseases for Senile Cataract

Diseases related to Senile Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 mature cataract 33.0 CRYGS CRYAA
2 microvascular complications of diabetes 5 30.4 SOD1 SERPINF1 CRYAA ALB
3 premature aging 30.3 WRN LMNA
4 aging 30.2 WRN SOD1 LMNA
5 retinal vascular disease 30.1 SERPINF1 CRYAA ALB
6 autosomal recessive disease 29.6 XRCC1 WRN LMNA CRYAA
7 presbyopia 29.6 CRYGS CRYAA BFSP1
8 diabetic cataract 28.9 SERPINF1 GSR G6PD CRYGS CRYAA CAT
9 cataract 26.5 XRCC1 WRN TKT TALDO1 SOD1 SERPINF1
10 nuclear senile cataract 12.8
11 cortical senile cataract 12.6
12 immature cataract 12.3
13 morgagni cataract 11.8
14 intraocular pressure quantitative trait locus 10.5
15 hearing loss, noise-induced 10.5 GSTT1 GSTM1
16 congenital methemoglobinemia 10.4 SOD1 G6PD
17 isolated cleft lip 10.4 GSTT1 GSTM1
18 trimethoprim allergy 10.4 GSTM1 GSR G6PD
19 sister chromatid exchange, frequency of 10.4 XRCC1 GSTT1 GSTM1
20 yemenite deaf-blind hypopigmentation syndrome 10.4
21 mutagen sensitivity 10.4 XRCC1 GSTT1 GSTM1
22 meningococcal infection 10.4 SOD1 GSR G6PD
23 lymphosarcoma 10.4 GSR G6PD
24 cardia cancer 10.3 XRCC1 GSTT1 GSTM1
25 methemoglobinemia 10.3 SOD1 GSR G6PD
26 drug-induced hepatitis 10.3 GSTT1 GSTM1 ALB
27 macular degeneration, age-related, 1 10.3
28 myopia 10.3
29 early-onset nuclear cataract 10.3 EPHA2 CRYAA BFSP1
30 eales disease 10.3 SOD1 SERPINF1
31 hydrops of gallbladder 10.3 G6PD ALB
32 atypical werner syndrome 10.2 WRN LMNA
33 carbohydrate metabolic disorder 10.2 GALK1 G6PD CRYAA
34 galactosemia 10.2 GALK1 G6PD CRYAA
35 astigmatism 10.2
36 open-angle glaucoma 10.2
37 diabetes mellitus 10.2
38 acroosteolysis 10.2 LMNA ALB
39 transaldolase deficiency 10.2 TKT TALDO1
40 inflammatory and toxic neuropathy 10.2 TKT ALB
41 exudative vitreoretinopathy 1 10.2 SERPINF1 CRYAA ALB
42 cataract 6, multiple types 10.2 EPHA2 CRYAA
43 critical illness polyneuropathy 10.1 CS ALB
44 strabismus 10.1
45 microvascular complications of diabetes 1 10.1
46 microvascular complications of diabetes 2 10.1
47 hydrops, lactic acidosis, and sideroblastic anemia 10.1
48 uveitis 10.1
49 glucosephosphate dehydrogenase deficiency 10.1
50 macular retinal edema 10.1

Graphical network of the top 20 diseases related to Senile Cataract:



Diseases related to Senile Cataract

Symptoms & Phenotypes for Senile Cataract

MGI Mouse Phenotypes related to Senile Cataract:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 ALB BFSP1 EPHA2 G6PD GSR LMNA
2 neoplasm MP:0002006 9.5 ALB CAT EPHA2 OGG1 SOD1 WRN
3 vision/eye MP:0005391 9.32 BFSP1 CRYGS EPHA2 GALK1 GSR LMNA

Drugs & Therapeutics for Senile Cataract

Drugs for Senile Cataract (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
2
Nepafenac Approved, Investigational Phase 4 78281-72-8 151075
3
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
4
Bromfenac Approved Phase 4 91714-94-2 60726
5 Polymethyl Methacrylate Phase 4
6 Vasodilator Agents Phase 4
7 Cyclooxygenase Inhibitors Phase 4
8 Ketorolac Tromethamine Phase 4
9 Anti-Inflammatory Agents Phase 4
10 Anti-Inflammatory Agents, Non-Steroidal Phase 4
11 Viscosupplements Phase 4
12 Analgesics, Non-Narcotic Phase 4
13 Adjuvants, Immunologic Phase 4
14 Protective Agents Phase 4
15 Antirheumatic Agents Phase 4
16 Immunologic Factors Phase 4
17 Analgesics Phase 4
18
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
19
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
20
Povidone Approved 9003-39-8
21
Iodine Approved, Investigational 7553-56-2 807
22
Lidocaine Approved, Vet_approved 137-58-6 3676
23
Oxymetazoline Approved, Investigational 1491-59-4 4636
24
Povidone-iodine Approved 25655-41-8
25
Phenylephrine Approved 59-42-7 6041
26
Dipivefrin Approved 52365-63-6 3105
27
Tropicamide Approved, Investigational 1508-75-4 5593
28 Gastrointestinal Agents
29 Antiemetics
30 HIV Protease Inhibitors
31
protease inhibitors
32 Hormone Antagonists
33 Autonomic Agents
34 BB 1101
35 Antineoplastic Agents, Hormonal
36 glucocorticoids
37 Hormones
38 Lycium
39 Goji
40 Anesthetics, Local
41 Anti-Arrhythmia Agents
42 Sodium Channel Blockers
43
Chondroitin 9007-27-6 53477707
44 Diuretics, Potassium Sparing
45 cadexomer iodine
46 Anesthetics
47 Central Nervous System Depressants

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Posterior Capsule Opacification After Implantation of Square Edge PMMA, Round Edge PMMA and Acrysof Intraocular Lenses: Randomized Controlled Study Completed NCT00312299 Phase 4
2 Comparison of Ketorolac Tromethamine 0.4% and Nepafenac 0.1% for the Prevention of Cystoid Macular Edema After Phacoemulsification: Prospective Randomized Double-masked Study Completed NCT02084576 Phase 4 Nepafenac;Ketorolac
3 Topical 0,09% Bromfenac for Intraoperative Miosis and Pain Reduction in Femtosecond Laser-assisted Cataract Surgery Enrolling by invitation NCT03831984 Phase 4 0,09% Bromfenac;0,1% sodium hyaluronate
4 Clinical Evaluation of the Aspheric SeeLens AF Intra-Ocular Lens. Unknown status NCT00825747 Phase 3
5 Standard Coaxial Microincision Cataract Surgery Versus Coaxial Microincision Cataract Surgery Using 1% Ultrasound in Immature Senile Cataract :a Corneal Endothelium Study Unknown status NCT01259349 Phase 3
6 The Efficiency of a New Device for Performing Capsulorhexis in Cataract Surgery Unknown status NCT01396967 Phase 1
7 To Investigate Tear Film Change After Phacoemulsification With SS-OCT Unknown status NCT02238015
8 An Investigator-Initiated Trials on the Efficacy and Stability of AT TORBI 709M 4-haptic Toric IOL in Cataract Surgery Unknown status NCT02618018
9 Safety and Efficacy of Implantation of Two Multifocal Intraocular Lenses in the Treatment of Senile Cataract: a Randomized Controlled Clinical Trial Unknown status NCT02966496
10 Neural Compensation, Visual Function and Visual Quality in Senile Cataract Patients After Monofocal or Multifocal Intraocular Lens Implantation Unknown status NCT02644720 Dexamethasone
11 Effects of Lycium Barbarum Supplements on the Progression of Senile Cataract in Hong Kong Chinese Population Completed NCT01142960
12 A Twelve-Months, Single-Masked, Parallel Group, Health Economic Study of Phacoemulsification Versus Small Incision Cataract Surgery (SICS) in Chinese Patients With Senile Cataract. Completed NCT00762606
13 Prospective Evaluation of Posterior Capsule Opacification in Myopic Eyes 4 Years After AcrySof Single-Piece IOL Implantation Completed NCT00855491
14 Surgically Induced Astigmatism of Temporal Versus Nasal Clear Corneal Phacoemulsification Completed NCT00521833
15 Liquefaction Versus Torsional ip. A Comparative Study on Endothelial Cells, Corneal Edema and Corneal Sensitivity Completed NCT01480557
16 Viscoat Versus Visthesia. A Comparative Study of Post-cataract Endothelial Cell Loss Completed NCT02304861
17 Randomized, Controlled Trial in Patients With Senile Cataract to Evaluate the Efficacy of Ultrasound-free Femtosecond Laser (FLACS) Cataract Surgery (USFREE), Compared to Traditional Phacoemulsification Surgery Using Ultrasound. Completed NCT03050008
18 Refractive Outcome and Optimization of IOL-Constants After Implantation of the Precisight® Intraocular Lens. Active, not recruiting NCT02970487
19 Corneal Endothelial Cell Loss After Phacoemulsification Compared With Extracapsular Cataract Extraction in Management of Senile Cataract Not yet recruiting NCT03262285
20 An Epidemiological Observational Study for Retrospective and Prospective Evaluation of for the Prevalence of Cerebrotendinous Xanthomatosis (CTX) Disease in Neurology and Pediatric Metabolism Clinics in Turkey Not yet recruiting NCT04113083
21 Subclinical Sympathetic Response Related to Second-eye Pain in Cataract Surgery and Its Noninvasive Detection Index Not yet recruiting NCT03766230

Search NIH Clinical Center for Senile Cataract

Genetic Tests for Senile Cataract

Anatomical Context for Senile Cataract

MalaCards organs/tissues related to Senile Cataract:

40
Eye, Endothelial, Testes, Retina, Salivary Gland, Skin, Brain

Publications for Senile Cataract

Articles related to Senile Cataract:

(show top 50) (show all 1310)
# Title Authors PMID Year
1
Glucose-6-phosphate dehydrogenase (G6PD) deficiency and senile cataract in a Sardinian male population, Italy. 54 61
19995205 2009
2
The evaluation of the oxidative stress parameters in nondiabetic and diabetic senile cataract patients. 54 61
18982249 2009
3
Implication of glutathione S-transferase M1 and T1 polymorphisms in the development of senile cataract among Egyptians. 54 61
20120433 2009
4
Activity of superoxide dismutase obtained from senile cataract lens - effect of diabetes mellitus. 54 61
19093039 2008
5
Role of anti-oxidant enzymes superoxide dismutase and catalase in the development of cataract : study of serum levels in patients with senile and diabetic cataracts. 54 61
17240813 2006
6
Decreased glucose-6-phosphate-dehydrogenase (G6PD) activity and risk of senile cataract in Taiwan. 54 61
16581614 2006
7
Erythrocyte antioxidant enzymes in patients with cataract. 54 61
16682518 2006
8
Downregulation of gene expression in the ageing lens: a possible contributory factor in senile cataract. 54 61
15105821 2005
9
Changes in glutathione, glutathione-linked enzymes and hexose monophosphate shunt enzymes in senile cataract. 54 61
15255623 2003
10
[The study on superoxide dismutase and trace element in patients with senile cataract]. 54 61
12579780 2000
11
Polymorphic glutathione S-transferases as genetic risk factors for senile cortical cataract in Estonians. 54 61
10892871 2000
12
[Relationship between GSTM1 genotype and susceptibility to senile cataract]. 54 61
11835784 1999
13
The study of G6PD in erythrocyte and lens in senile and presenile cataract. 54 61
1286674 1992
14
Senile cataract and glucose-6-phosphate dehydrogenase deficiency in Indians. 54 61
2100077 1990
15
Evaluation of Barrett universal II formula for intraocular lens power calculation in Asian Indian population. 61
31856468 2020
16
Aqueous cytokine levels in four common uveitis entities. 61
31776091 2020
17
Frequency of Corneal Astigmatism in Patients Presenting for Senile Cataract Surgery at a Teaching Hospital in Indian Rural Population. 61
31923034 2020
18
Aqueous humor and serum 25-Hydroxyvitamin D levels in patients with cataracts. 61
31906919 2020
19
Comorbidity of keratoconus and Fuchs' corneal endothelial dystrophy: a review of the literature. 61
31865313 2019
20
Higher aqueous levels of matrix metalloproteinases indicated visual impairment in patients with retina vein occlusion after anti-VEGF therapy. 61
31843793 2019
21
Carnosine Prevents Different Structural Damages Induced by Methylglyoxal in Lens Crystallins. 61
31535344 2019
22
A comparative study of stereoacuity in patients with various grades of cataract and bilateral pseudophakia. 61
31638044 2019
23
The efficacy of "IOL-Vip Revolution" telescopic intraocular lens in age-related macular degeneration cases with senile cataract. 61
30280594 2019
24
Possible therapeutic effect of magnesium in ocular diseases. 61
31730524 2019
25
Association of LOXL1 Gene Polymorphisms with Exfoliation Glaucoma Patients. 61
31850260 2019
26
Abnormal levels of aqueous humor trace elements in patients with cytomegalovirus retinitis. 61
31065104 2019
27
Sequelae of neglected hypermature senile cataract. 61
31546522 2019
28
Metabolic characterization of diabetic retinopathy: An 1H-NMR-based metabolomic approach using human aqueous humor. 61
31212142 2019
29
Rare atypical presentation of phacolytic glaucoma as non-resolving microbial keratitis with endophthalmitis. 61
31527222 2019
30
Comparison of effective phacoemulsification time and corneal endothelial cell loss using 2 ultrasound frequencies. 61
31371150 2019
31
An in vivo confocal microscopy study of corneal changes in pseudoexfoliation syndrome. 61
30280588 2019
32
Posterior capsule opacification and Nd:YAG laser rates with two hydrophobic acrylic single-piece IOLs. 61
31485039 2019
33
A comparison of posterior capsular opacification after implantation of three different hydrophobic square edge intraocular lenses. 61
31436185 2019
34
MYH9-related disorders display heterogeneous kidney involvement and outcome. 61
31384440 2019
35
Increased Aqueous Humor Symmetric Dimethylarginine Level in Patients with Primary Open Angle Glaucoma. 61
30707048 2019
36
Changes in ocular surface status after phacoemulsification in patients with senile cataract. 61
29926365 2019
37
Changes in subfoveal choroidal thickness after uncomplicated cataract surgery. 61
30565567 2019
38
Negative charge at aspartate 151 is important for human lens αA-crystallin stability and chaperone function. 61
30849387 2019
39
Pigment epithelial-derived factor in the lens anterior capsule of patients with senile cataract with pseudoexfoliation. 61
31090113 2019
40
Risk of cataract removal surgery in Mayak PA workers occupationally exposed to ionizing radiation over prolonged periods. 61
30879144 2019
41
Cataract surgery outcomes in eyes with chorioretinal coloboma. 61
31030778 2019
42
Digital droplet polymerase chain reaction analysis of common viruses in the aqueous humour of patients with Posner-Schlossman syndrome in Chinese population. 61
30414235 2019
43
Active-fluidics-based torsional phacoemulsification in diabetic eyes: A prospective interventional study. 61
31007221 2019
44
Prevalence of diabetes and diabetic macular edema in patients undergoing senile cataract surgery in Italy: The DIabetes and CATaract study. 61
30854895 2019
45
[The role of caveolae in cataractogenesis: examination of human lens epithelial cells]. 61
30773032 2019
46
Perceived difficulties and complications in learners of phacoemulsification: A principal component analysis model. 61
30672472 2019
47
Pilot Results of Implantation of the New Hydrophobic Intraocular Lens Zeiss LUCIA 611P in the Czech Republic. 61
31234632 2019
48
Cataract Surgery in HIV Seropositive Patients: Long-Term Follow-Up. 61
29333896 2019
49
Functional and anatomical evaluation of the effect of nepafenac in prevention of macular edema after phacoemulsification in diabetic patients. 61
30918805 2019
50
Comparison of Outcomes after Phacoemulsification with Two Different Corneal Incision Distances Anterior to the Limbus. 61
31531233 2019

Variations for Senile Cataract

Expression for Senile Cataract

Search GEO for disease gene expression data for Senile Cataract.

Pathways for Senile Cataract

Pathways related to Senile Cataract according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1 12.27 TKT G6PD CS CAT
2
Show member pathways
12.07 SOD1 GSR CAT ALB
3
Show member pathways
11.98 GSTT1 GSTM1 GSR G6PD
4 11.72 GSTM1 GSR G6PD EPHA2
5
Show member pathways
11.39 TKT TALDO1 G6PD
6
Show member pathways
11.35 TKT TALDO1 G6PD CS CAT
7
Show member pathways
11.24 SOD1 GSR CAT
8 10.82 SOD1 GSR CAT
9 10.75 GSR G6PD
10 10.66 TALDO1 G6PD
11 10.59 SOD1 GSTT1 GSTM1

GO Terms for Senile Cataract

Cellular components related to Senile Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.36 TKT TALDO1 SOD1 SERPINF1 GSTT1 GSR

Biological processes related to Senile Cataract according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.91 SOD1 OGG1 CRYAA CAT ALB
2 response to drug GO:0042493 9.84 XRCC1 SOD1 OGG1 CAT
3 carbohydrate metabolic process GO:0005975 9.8 TALDO1 GALK1 G6PD CS
4 response to oxidative stress GO:0006979 9.73 WRN SOD1 OGG1 CAT
5 response to ethanol GO:0045471 9.71 SOD1 OGG1 G6PD CAT
6 base-excision repair GO:0006284 9.63 XRCC1 WRN OGG1
7 cellular response to oxidative stress GO:0034599 9.62 SOD1 GSR G6PD CAT
8 cellular oxidant detoxification GO:0098869 9.56 GSTT1 GSR CAT ALB
9 aging GO:0007568 9.55 WRN SOD1 SERPINF1 OGG1 CAT
10 response to reactive oxygen species GO:0000302 9.52 SOD1 CAT
11 pentose-phosphate shunt, non-oxidative branch GO:0009052 9.48 TKT TALDO1
12 xylulose biosynthetic process GO:0005999 9.37 TKT TALDO1
13 pentose-phosphate shunt GO:0006098 9.13 TKT TALDO1 G6PD
14 glutathione metabolic process GO:0006749 9.02 SOD1 GSTT1 GSTM1 GSR G6PD

Molecular functions related to Senile Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.73 WRN TKT SOD1 GSTM1 G6PD CAT
2 NADP binding GO:0050661 9.33 GSR G6PD CAT
3 antioxidant activity GO:0016209 9.13 SOD1 CAT ALB
4 structural constituent of eye lens GO:0005212 8.8 CRYGS CRYAA BFSP1

Sources for Senile Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....