MCID: SNL007
MIFTS: 40

Senile Cataract

Categories: Eye diseases, Genetic diseases

Aliases & Classifications for Senile Cataract

MalaCards integrated aliases for Senile Cataract:

Name: Senile Cataract 12 55 15

Classifications:



External Ids:

Disease Ontology 12 DOID:9669
ICD10 33 H25
ICD9CM 35 366.1 366.10
NCIt 50 C35012
SNOMED-CT 68 39450006
UMLS 73 C0036646

Summaries for Senile Cataract

MalaCards based summary : Senile Cataract is related to nuclear senile cataract and cortical senile cataract. An important gene associated with Senile Cataract is GSTM1 (Glutathione S-Transferase Mu 1), and among its related pathways/superpathways are Selenium Micronutrient Network and NRF2 pathway. The drugs Dipivefrin and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and testes.

Related Diseases for Senile Cataract

Diseases related to Senile Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 nuclear senile cataract 12.3
2 cortical senile cataract 12.3
3 immature cataract 11.6
4 mature cataract 11.1
5 cataract 11.1
6 leukoplakia 10.2 GSTM1 GSTT1
7 hearing loss, noise-induced 10.2 GSTM1 GSTT1
8 isolated cleft lip 10.2 GSTM1 GSTT1
9 drug-induced hepatitis 10.2 GSTM1 GSTT1
10 arteritic anterior ischemic optic neuropathy 10.2 GSTM1 GSTT1
11 diffuse gastric cancer 10.2 GSTM1 GSTT1
12 congenital methemoglobinemia 10.2 G6PD SOD1
13 laryngeal disease 10.2 GSTM1 GSTT1
14 neonatal jaundice 10.2 G6PD GSTM1
15 asbestosis 10.2 GSTM1 GSTT1
16 oligospermia 10.2 GSTM1 GSTT1
17 oral submucous fibrosis 10.1 GSTM1 GSTT1
18 lymphosarcoma 10.1 G6PD GSR
19 aging 10.1
20 macular degeneration, age-related, 1 10.1
21 microvascular complications of diabetes 5 10.1
22 open-angle glaucoma 10.1
23 morgagni cataract 10.1 CRYAA GSR
24 ischemic optic neuropathy 10.1 G6PD GSTM1 GSTT1
25 varicocele 10.1 GSTM1 GSTT1
26 eales disease 10.1 SERPINF1 SOD1
27 sister chromatid exchange, frequency of 10.1 GSTM1 GSTT1 XRCC1
28 oral leukoplakia 10.1 GSTM1 GSTT1 XRCC1
29 cardia cancer 10.1 GSTM1 GSTT1 XRCC1
30 mutagen sensitivity 10.1 GSTM1 GSTT1 XRCC1
31 xeroderma pigmentosum, complementation group d 10.1 GSTM1 GSTT1 XRCC1
32 multinodular goiter 10.1 GSR SOD1
33 glaucoma, primary open angle 10.1
34 strabismus 10.1
35 diabetes mellitus 10.1
36 glucosephosphate dehydrogenase deficiency 10.1
37 meningococcal infection 10.1 G6PD GSR SOD1
38 basal cell carcinoma 10.0 GSTM1 GSTT1 XRCC1
39 early-onset nuclear cataract 10.0 BFSP1 CRYAA
40 pneumoconiosis 10.0 GSTM1 SOD1
41 meningitis and encephalitis 10.0 ALB SOD1
42 parotitis 10.0 ALB G6PD
43 kernicterus 10.0 ALB G6PD
44 ariboflavinosis 10.0 ALB GSR
45 toxic encephalopathy 10.0 GSTM1 GSTT1
46 bilirubin metabolic disorder 9.9 ALB G6PD
47 microvascular complications of diabetes 1 9.9
48 microvascular complications of diabetes 2 9.9
49 glucose intolerance 9.9
50 keratomalacia 9.9

Graphical network of the top 20 diseases related to Senile Cataract:



Diseases related to Senile Cataract

Symptoms & Phenotypes for Senile Cataract

Drugs & Therapeutics for Senile Cataract

Drugs for Senile Cataract (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dipivefrin Approved Phase 4,Not Applicable 52365-63-6 3105
2
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
3
Racepinephrine Approved Phase 4 329-65-7 838
4
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
5
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
6
Epicatechin Investigational Phase 4 490-46-0 72276
7
Theobromine Investigational Phase 4 83-67-0 5429
8 Anesthetics Phase 4,Not Applicable
9 Central Nervous System Depressants Phase 4,Not Applicable
10 Anti-Inflammatory Agents Phase 4,Not Applicable
11 Peripheral Nervous System Agents Phase 4,Not Applicable
12 Neurotransmitter Agents Phase 4,Not Applicable
13 Adrenergic Agonists Phase 4,Not Applicable
14 Adrenergic Agents Phase 4,Not Applicable
15 Epinephryl borate Phase 4
16 Ketorolac Tromethamine Phase 4
17 Analgesics Phase 4
18 Anti-Inflammatory Agents, Non-Steroidal Phase 4
19 Analgesics, Non-Narcotic Phase 4
20 Antirheumatic Agents Phase 4
21 Cyclooxygenase Inhibitors Phase 4
22 Pharmaceutical Solutions Phase 2,Not Applicable
23 Ophthalmic Solutions Phase 2,Not Applicable
24
Dexamethasone Approved, Investigational, Vet_approved Not Applicable 50-02-2 5743
25
Dexamethasone acetate Approved, Investigational, Vet_approved Not Applicable 1177-87-3
26
Glycerol Approved, Investigational Not Applicable 56-81-5 753
27
Tobramycin Approved, Investigational Not Applicable 32986-56-4 36294 5496
28 Propoxycaine Approved Not Applicable 86-43-1
29
Tropicamide Approved, Investigational Not Applicable 1508-75-4 5593
30
Hyaluronic acid Approved, Vet_approved Not Applicable 9004-61-9 53477741
31
Phenylephrine Approved Not Applicable 59-42-7 6041
32
Oxymetazoline Approved, Investigational Not Applicable 1491-59-4 4636
33
Ephedrine Approved Not Applicable 299-42-3 9294
34
Iodine Approved, Investigational Not Applicable 7553-56-2 807
35
Povidone-iodine Approved Not Applicable 25655-41-8
36
Povidone Approved Not Applicable 9003-39-8
37
Pseudoephedrine Approved Not Applicable 90-82-4 7028
38
Dinoprostone Approved Not Applicable 363-24-6 5280360
39 BB 1101 Not Applicable
40 Gastrointestinal Agents Not Applicable
41 Hormone Antagonists Not Applicable
42 Antineoplastic Agents, Hormonal Not Applicable
43 Autonomic Agents Not Applicable
44 Hormones Not Applicable
45 Antiemetics Not Applicable
46 HIV Protease Inhibitors Not Applicable
47 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
48 glucocorticoids Not Applicable
49
protease inhibitors Not Applicable
50 Plasma Substitutes Not Applicable

Interventional clinical trials:

(show top 50) (show all 62)
# Name Status NCT ID Phase Drugs
1 Outcomes of Phacoemulsification With Torsional Ultrasound Completed NCT01010490 Phase 4
2 A Comparison of One-site and Two-site Peribulbar Anaesthesia for Cataract Surgery at Kaduna, Nigeria Completed NCT02150460 Phase 4
3 Effect of Optic Edge Design in a Silicone Intraocular Lens on Posterior Capsule Opacification Completed NCT00428363 Phase 4
4 Protein Profile of Immunoregulatory Factors in Diabetic Cataract Completed NCT01832311 Phase 4 Ketorolac
5 Cataract and AMD in a Trial of a Multivitamin and Cocoa Extract Enrolling by invitation NCT03205202 Phase 4
6 Effect of Minimising Ultrasound Power to 1% During Cataract Surgery on Corneal Endothelium. Unknown status NCT01259349 Phase 3
7 Evaluation of Seelens AF, an Aspheric Intra-Ocular Lens Unknown status NCT00825747 Phase 3
8 Collaborative Italian-American Clinical Trial of Nutritional Supplements and Age-related Cataract (CTNS) Completed NCT00309387 Phase 3
9 Safety and Efficacy Study of an Ophthalmic Solution in Patients With Age-Related Cataract Unknown status NCT00793091 Phase 2 C-KAD Ophthalmic Solution;Placebo
10 Dose-Ranging Study of an Ophthalamic Solution in Patients With Loss of Visual Function Due to Age-Related Nuclear Cataract Unknown status NCT00825721 Phase 2 LiquiTears;C-KAD Ophthalmic Solution;C-KAD Ophthalmic Solution;C-KAD Ophthalmic Solution
11 Safety and Efficacy of Implantation of Two Multifocal Intraocular Lenses in the Treatment of Senile Cataract Unknown status NCT02966496 Not Applicable
12 Tear Film Evaluation After Phacoemulsification Unknown status NCT02238015
13 Two Different Cataract Surgical Procedures to Prevent Posterior Capsule Opacification Unknown status NCT02445274 Not Applicable
14 Neural Compensation, Visual Function and Visual Quality After Monofocal or Multifocal Intraocular Lens Implantation Unknown status NCT02644720 Not Applicable Dexamethasone
15 Effects of Holy-Comod and Tears Naturale Forte in Patients After Phaco+IOL Unknown status NCT02817191 Not Applicable Hylo-Comod eye drop;Tears Naturale Forte eye drop
16 The Effect of Cataract Surgery on Sleep Quality Unknown status NCT02593669 Not Applicable Subconjunctival dexamethasone and general anesthesia;Viscoelastic materials
17 Effects of Lycium Barbarum Supplements on the Progression of Senile Cataract in Hong Kong Chinese Population Completed NCT01142960 Not Applicable
18 Efficacy of FLACS USFREE Compared to Traditional Surgery Using Ultrasound. Completed NCT03050008 Not Applicable
19 Subfoveal Choroidal Thickness After Surgery for Age-related Cataracts Completed NCT02895074 Not Applicable Tropicamide;Proparacaine hydrochloride
20 Pilot Study: Dynamic Light Scattering Device for Studying Early Changes in Cataract Completed NCT00067483
21 Release of Proinflammatory Cytokines (IL-1β, IL-6) and Total-prostaglandin (PG) Following Femtosecond Laser-assisted Cataract Surgery Compared to Manual Cataract Surgery Completed NCT03390361 Not Applicable
22 A Prospective Observational Case Series of a Four-ring-haptic Acrylic One-piece IOL Completed NCT01244373
23 Phaco Versus Small Incision Cataract Surgery (SICS) Health Economic Study Completed NCT00762606 Not Applicable
24 Clinical Evaluation of Multifocal Intraocular Lens: OPTIVIS.TM Completed NCT03512626 Not Applicable
25 Mid-term Evaluation of Metamorphopsia in Epiretinal Membrane Surgery Completed NCT03045367
26 Intraocular Pressure Variation by Pneumatic Tonometer Before and After Phacoemulsification Completed NCT03016507
27 Anterior Capsule Polishing Effect on Effective Lens Position Completed NCT01598428 Not Applicable
28 Viscoat Versus Visthesia. A Comparative Study of Post-cataract Endothelial Cell Loss Completed NCT02304861 Not Applicable
29 Aqualase Versus Torsional ip. A Study on Endothelial Cells, Corneal Edema and Corneal Sensitivity Completed NCT01480557 Not Applicable
30 Evaluation of Posterior Capsule Opacification in Eyes With Diabetes Mellitus Completed NCT01480934
31 Clinical Analysis of Ocular Parameters Contributing to Intraoperative Pain During Standard Phacoemulsification Completed NCT03031652
32 Evaluation of the Age-Related Eye Disease Study (AREDS) Clinical Lens Grading System Completed NCT00078299
33 How Astigmatism Influences Corneal Biomechanics and Intraocular Pressure Completed NCT03162471
34 A Pilot Study Simulating Multifocal Intraocular Lenses in Healthy Subjects Completed NCT01873781 Cyclopentolatehydrochloride
35 Comparison of the Effect of Hydrophobic Acrylic and Silicone 3-piece IOLs on Posterior Capsule Opacification Completed NCT01936701 Not Applicable
36 Posterior Capsule Opacification and Frequency of Nd:YAG Treatment and of Two IOLs: Hoya iMics Y-60H vs. Bausch&Lomb MI60 (MIMI) Completed NCT01786356 Not Applicable
37 Posterior Capsule Opacification Development With Two Different Intraocular Lenses Completed NCT01734343 Not Applicable
38 Patient Participation in Free Cataract Surgery Completed NCT02633865
39 A Pilot Study Investigating the Impact of Different IOL Designs on Subjective 2D and 3D Image Quality Completed NCT02409641 Not Applicable Cyclopentolatehydrochloride 0,5% eye drops
40 Performance of a Single-piece Toric Acrylic Intraocular Lens Completed NCT02155959
41 Rotation of an Intraocular Lens - HOYA Vivinex iSert P261 Completed NCT03157375 Not Applicable
42 Posterior Capsule Opacification and Frequency of Nd:YAG Treatment and of Two Microincision IOLs: Hoya iMics NY-60 vs Acrysof SN60WF Completed NCT01732484 Not Applicable
43 Posterior Capsule Opacification and Frequency of Nd:YAG Treatment and of Two Microincision IOLs: Tecnis ZCB00 and Acrysof SA60AT Completed NCT01742910 Not Applicable
44 Comparison of In-the-bag Stability Between Single-piece and Three-piece Intraocular Lens Completed NCT02609997 Not Applicable Subconjunctival dexamethasone;proparacaine
45 Dynamic Light Scattering for Studying Lens Aging and Cataract Formation Completed NCT00081991
46 Long-term Evaluation of Single-piece ACrysof IOL Implantation on Development of Posterior Capsule Opacification Completed NCT01820065
47 Comparison of Manual Super Small Incision Cataract Surgery and Phacoemulsification Completed NCT01146964 Not Applicable
48 Dysfunctional Lens Index Serves as a Novel Surgery Decision Maker for Age-related Cataracts Recruiting NCT03340389 Not Applicable
49 Shanghai High Myopia Study Recruiting NCT03062085
50 Precisight® Intraocular Lens Implantation for Cataract Treatment Recruiting NCT02970487 Not Applicable

Search NIH Clinical Center for Senile Cataract

Genetic Tests for Senile Cataract

Anatomical Context for Senile Cataract

MalaCards organs/tissues related to Senile Cataract:

41
Eye, Endothelial, Testes, Skin, Cortex, Brain, Liver

Publications for Senile Cataract

Articles related to Senile Cataract:

(show top 50) (show all 283)
# Title Authors Year
1
Diagnosis related group grouping study of senile cataract patients based on E-CHAID algorithm. ( 29487824 )
2018
2
Serum Oxidative Stress Markers in Patients with Senile Cataract and Healthy Controls. ( 29848421 )
2018
3
The geospatial relationship of pterygium and senile cataract with ambient solar ultraviolet in tropical Ecuador. ( 29926886 )
2018
4
Changes in ocular surface status after phacoemulsification in patients with senile cataract. ( 29926365 )
2018
5
The efficacy of "IOL-Vip Revolution" telescopic intraocular lens in age-related macular degeneration cases with senile cataract. ( 30280594 )
2018
6
Comparison of the mechanical properties of the anterior lens capsule in senile cataract, senile cataract with trypan blue application, and pseudoexfoliation syndrome. ( 28917406 )
2017
7
Comparison of visual performance and after cataract formation between two monofocal aspheric intraocular lenses following phacoemulsification for senile cataract: A randomized controlled study. ( 29208832 )
2017
8
Genetic testing of individuals with pre-senile cataract identifies patients with myotonic dystrophy type 2. ( 29024355 )
2017
9
Association of angiotensin-converting enzyme, CYP46A1 genes polymorphism with senile cataract. ( 28298860 )
2017
10
Comment on: Comparison of serum sodium and potassium levels in patients with senile cataract and age-matched individuals without cataract. ( 28345578 )
2017
11
Comment on: Comparison of serum sodium and potassium levels in patients with senile cataract and age-matched individuals without cataract. ( 28345577 )
2017
12
The Incidence of Senile Cataract and Glaucoma is Increased in Patients with Plasma Cell Dyscrasias: Etiologic Implications. ( 27328652 )
2016
13
The Predictability of Preoperative Pilocarpine-Induced Lens Shift on the Outcomes of Accommodating Intraocular Lenses Implanted in Senile Cataract Patients. ( 27516899 )
2016
14
Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract. ( 27703255 )
2016
15
Prevalence of Pseudoexfoliation Syndrome in Turkish Patients with Senile Cataract. ( 26795697 )
2016
16
Senile cataract and genetic polymorphisms of APE1, XRCC1 and OGG1. ( 26884880 )
2015
17
Comparison of preoperative nepafenac (0.1%) and flurbiprofen (0.03%) eye drops in maintaining mydriasis during small incision cataract surgery in patients with senile cataract: A randomized, double-blind study. ( 26600636 )
2015
18
Characteristics of the Anterior Segment Biometry and Corneal Endothelium in Eyes with Pseudoexfoliation Syndrome and Senile Cataract. ( 27800230 )
2015
19
Analytical and physicochemical characterisation of the senile cataract drug dipeptide I^-alanyl-L-histidine (carnosine). ( 26073114 )
2015
20
Serum free Fatty acids level in senile cataract. ( 25079310 )
2014
21
Cost-of-Illness Study of Senile Cataract in the Czech Republic. ( 27202109 )
2014
22
Xanthine oxidase and lens oxidative stress markers in diabetic and senile cataract patients. ( 23142692 )
2013
23
Sequelae of neglected senile cataract. ( 25606266 )
2013
24
Primary posterior capsular opacification in Indian rural population undergoing cataract surgery for hypermature senile cataract. ( 23966767 )
2013
25
Comparison of serum sodium and potassium levels in patients with senile cataract and age-matched individuals without cataract. ( 23552357 )
2013
26
C1824T mutation in the LMNA gene has no association with senile cataract. ( 22079058 )
2012
27
Common genetic link between metabolic syndrome components and senile cataract. ( 22165987 )
2012
28
Quantitative assessment of DNA damage directly in lens epithelial cells from senile cataract patients. ( 21224996 )
2011
29
Idiopathic phacodonesis in senile cataract patients in Qinghai, China. ( 22553712 )
2011
30
To assess the levels of zinc in serum and changes in the lens of diabetic and senile cataract patients. ( 22360021 )
2011
31
Lack of association of the WRN C1367T polymorphism with senile cataract in the Israeli population. ( 20808731 )
2010
32
Association of glutathione S-transferases polymorphisms (GSTM1 and GSTT1) with senile cataract: a meta-analysis. ( 20574021 )
2010
33
Difference in redox status of serum and aqueous humor in senile cataract patients as monitored via the albumin thiol-redox state. ( 21191720 )
2010
34
Phospholipid and protein contents of lens proteolipids in human senile cataract. ( 19590524 )
2010
35
Characteristics of the corneal endothelium and pseudoexfoliation syndrome in patients with senile cataract. ( 20456430 )
2010
36
Implication of glutathione S-transferase M1 and T1 polymorphisms in the development of senile cataract among Egyptians. ( 20120433 )
2009
37
Comparative study of plasma ascorbic acid levels in senile cataract patients and in normal individuals. ( 19219683 )
2009
38
Glucose-6-phosphate dehydrogenase (G6PD) deficiency and senile cataract in a Sardinian male population, Italy. ( 19995205 )
2009
39
Synergistic effects of metal ion and the pre-senile cataract-causing G98R alphaA-crystallin: self-aggregation propensities and chaperone activity. ( 19862354 )
2009
40
Systemic redox modifications in senile cataract. ( 20446444 )
2009
41
The evaluation of the oxidative stress parameters in nondiabetic and diabetic senile cataract patients. ( 18982249 )
2009
42
Plasma Homocysteine, Folate and Vitamin B(12) levels in senile cataract. ( 23105765 )
2008
43
Activity of superoxide dismutase obtained from senile cataract lens - effect of diabetes mellitus. ( 19093039 )
2008
44
Evaluation of serum zinc level and plasma SOD activity in senile cataract patients under oxidative stress. ( 23105695 )
2007
45
Plasma redox status and premature onset of senile cataract. ( 17966444 )
2007
46
Occupational sunlight exposure, polymorphism of glutathione S-transferase M1, and senile cataract risk. ( 16551760 )
2006
47
[Senile cataract and strabismus]. ( 17290828 )
2006
48
Decreased glucose-6-phosphate-dehydrogenase (G6PD) activity and risk of senile cataract in Taiwan. ( 16581614 )
2006
49
Outcomes of cataract surgery in senile cataract patients at Siriraj Hospital: a prospective observational study. ( 16681057 )
2005
50
Sensory exotropia subsequent to senile cataract. ( 16358383 )
2005

Variations for Senile Cataract

Expression for Senile Cataract

Search GEO for disease gene expression data for Senile Cataract.

Pathways for Senile Cataract

GO Terms for Senile Cataract

Cellular components related to Senile Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.17 ALB G6PD GSR GSTT1 SERPINF1 SOD1

Biological processes related to Senile Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-12-mediated signaling pathway GO:0035722 9.4 SOD1 TALDO1
2 retina homeostasis GO:0001895 9.37 ALB SOD1
3 cellular response to oxidative stress GO:0034599 9.33 G6PD GSR SOD1
4 glutathione derivative biosynthetic process GO:1901687 9.32 GSTM1 GSTT1
5 pentose-phosphate shunt GO:0006098 9.26 G6PD TALDO1
6 cellular oxidant detoxification GO:0098869 9.13 ALB GSR GSTT1
7 glutathione metabolic process GO:0006749 9.02 G6PD GSR GSTM1 GSTT1 SOD1

Molecular functions related to Senile Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 9.32 ALB SOD1
2 NADP binding GO:0050661 9.26 G6PD GSR
3 antioxidant activity GO:0016209 9.16 ALB SOD1
4 glutathione transferase activity GO:0004364 8.96 GSTM1 GSTT1
5 structural constituent of eye lens GO:0005212 8.62 BFSP1 CRYAA

Sources for Senile Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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