MCID: SNL007
MIFTS: 40

Senile Cataract

Categories: Eye diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Senile Cataract

MalaCards integrated aliases for Senile Cataract:

Name: Senile Cataract 12 54 15 32

Classifications:



External Ids:

Disease Ontology 12 DOID:9669
ICD9CM 34 366.1
NCIt 50 C35012
SNOMED-CT 67 39450006
ICD10 32 H25 H25.9
UMLS 71 C0036646

Summaries for Senile Cataract

Disease Ontology : 12 A cataract that is characterized by thickening and loss of transparency of the lens with age progression, caused by a multifactorial etiology related to aging.

MalaCards based summary : Senile Cataract is related to mature cataract and nuclear senile cataract. An important gene associated with Senile Cataract is CRYAA (Crystallin Alpha A), and among its related pathways/superpathways are DNA Damage and Glutathione metabolism. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and retina, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Senile Cataract

Diseases related to Senile Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 mature cataract 32.3 CRYGS CRYAA
2 nuclear senile cataract 32.3 GSR CRYGS BFSP1
3 morgagni cataract 31.9 CRYGS CRYAA
4 open-angle glaucoma 30.4 SOD1 GSTM1 CRYAA ALB
5 glucosephosphate dehydrogenase deficiency 30.3 GSR G6PD ALB
6 microvascular complications of diabetes 5 30.3 SERPINF1 CRYAA ALB
7 macular retinal edema 30.2 SERPINF1 CRYAA ALB
8 premature aging 30.0 WRN LMNA
9 retinal vascular disease 30.0 SERPINF1 CRYAA ALB
10 microvascular complications of diabetes 1 30.0 SERPINF1 CRYAA ALB
11 diabetic cataract 29.9 SERPINF1 GSR G6PD CRYGS CRYAA
12 presbyopia 29.9 CRYGS CRYAA BFSP1
13 diabetes mellitus 28.4 WRN SOD1 LMNA GSTM1 GSR G6PD
14 cataract 27.8 XRCC1 WRN TALDO1 SOD1 SERPINF1 OGG1
15 cortical senile cataract 11.6
16 immature cataract 11.5
17 intraocular pressure quantitative trait locus 10.5
18 hearing loss, noise-induced 10.4 GSTT1 GSTM1
19 thyroid tumor 10.4 GSTT1 GSTM1
20 yemenite deaf-blind hypopigmentation syndrome 10.3
21 isolated cleft lip 10.3 GSTT1 GSTM1
22 meningitis and encephalitis 10.3 SOD1 ALB
23 congenital methemoglobinemia 10.3 SOD1 G6PD
24 macular degeneration, age-related, 1 10.3
25 lymphosarcoma 10.3 GSR G6PD
26 trimethoprim allergy 10.3 GSTM1 GSR G6PD
27 myopia 10.3
28 blood group incompatibility 10.3 G6PD ALB
29 meningococcal infection 10.2 SOD1 GSR G6PD
30 eales disease 10.2 SOD1 SERPINF1
31 methemoglobinemia 10.2 SOD1 GSR G6PD
32 sister chromatid exchange, frequency of 10.2 XRCC1 GSTT1 GSTM1
33 posterior polar cataract 10.2 EPHA2 CRYAA BFSP1
34 multinodular goiter 10.2 SOD1 GSR G6PD
35 oral leukoplakia 10.2 XRCC1 GSTT1 GSTM1
36 mutagen sensitivity 10.2 XRCC1 GSTT1 GSTM1
37 early-onset nuclear cataract 10.2 EPHA2 CRYAA BFSP1
38 asbestosis 10.2 OGG1 GSTT1 GSTM1
39 gastroesophageal adenocarcinoma 10.2 XRCC1 GSTT1 GSTM1
40 varicocele 10.2 SOD1 GSTM1 ALB
41 cardia cancer 10.2 XRCC1 GSTT1 GSTM1
42 early-onset lamellar cataract 10.2 CRYGS CRYAA
43 galactosemia i 10.2 GALK1 G6PD CRYAA
44 astigmatism 10.2
45 disuse amblyopia 10.1 CRYGS CRYAA
46 critical illness polyneuropathy 10.1 CS ALB
47 parotitis 10.1 G6PD ALB
48 toxic encephalopathy 10.1 SOD1 GSTT1 GSTM1 ALB
49 cataract 6, multiple types 10.1 EPHA2 CRYAA
50 strabismus 10.1

Graphical network of the top 20 diseases related to Senile Cataract:



Diseases related to Senile Cataract

Symptoms & Phenotypes for Senile Cataract

GenomeRNAi Phenotypes related to Senile Cataract according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-2 9.74 EPHA2 GALK1 SOD1
2 Decreased viability GR00221-A-3 9.74 EPHA2 SOD1
3 Decreased viability GR00221-A-4 9.74 EPHA2 SOD1
4 Decreased viability GR00240-S-1 9.74 GALK1 LMNA
5 Decreased viability GR00249-S 9.74 ALB CRYAA G6PD GSR GSTM1 LMNA
6 Decreased viability GR00381-A-1 9.74 GSTM1 SERPINF1
7 Decreased viability GR00386-A-1 9.74 ALB G6PD GSTM1 LMNA
8 Decreased viability GR00402-S-2 9.74 CRYAA G6PD OGG1

MGI Mouse Phenotypes related to Senile Cataract:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 ALB APEX1 BFSP1 CS EPHA2 G6PD
2 cardiovascular system MP:0005385 9.96 ALB APEX1 BFSP1 EPHA2 G6PD GSR
3 neoplasm MP:0002006 9.5 ALB APEX1 EPHA2 OGG1 SOD1 WRN
4 vision/eye MP:0005391 9.28 BFSP1 CRYGS EPHA2 GALK1 GSR LMNA

Drugs & Therapeutics for Senile Cataract

Drugs for Senile Cataract (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
3
Dipivefrin Approved 52365-63-6 3105
4 Gastrointestinal Agents
5 Anti-Inflammatory Agents
6 Hormones
7 Hormone Antagonists
8 glucocorticoids
9 Antineoplastic Agents, Hormonal
10 Antiemetics
11 Polymethyl Methacrylate
12 Goji
13 Lycium
14 Anesthetics

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Standard Coaxial Microincision Cataract Surgery Versus Coaxial Microincision Cataract Surgery Using 1% Ultrasound in Immature Senile Cataract :a Corneal Endothelium Study Unknown status NCT01259349 Phase 3
2 Neural Compensation, Visual Function and Visual Quality in Senile Cataract Patients After Monofocal or Multifocal Intraocular Lens Implantation Unknown status NCT02644720 Dexamethasone
3 Safety and Efficacy of Implantation of Two Multifocal Intraocular Lenses in the Treatment of Senile Cataract: a Randomized Controlled Clinical Trial Unknown status NCT02966496
4 To Investigate Tear Film Change After Phacoemulsification With SS-OCT Unknown status NCT02238015
5 Rotational Stability of the Acrysof, Tecnis and Envista Intraocular Lenses Completed NCT04345380
6 A Twelve-Months, Single-Masked, Parallel Group, Health Economic Study of Phacoemulsification Versus Small Incision Cataract Surgery (SICS) in Chinese Patients With Senile Cataract. Completed NCT00762606
7 Effects of Lycium Barbarum Supplements on the Progression of Senile Cataract in Hong Kong Chinese Population Completed NCT01142960
8 Corneal Endothelial Cell Loss After Phacoemulsification Compared With Extracapsular Cataract Extraction in Management of Senile Cataract Completed NCT03262285
9 Randomized, Controlled Trial in Patients With Senile Cataract to Evaluate the Efficacy of Ultrasound-free Femtosecond Laser (FLACS) Cataract Surgery (USFREE), Compared to Traditional Phacoemulsification Surgery Using Ultrasound. Completed NCT03050008
10 Pilot Study on the Use of the NASA-NEI Dynamic Light Scattering (DLS) Device in Detecting Lens Changes in the Other Eye of Patients With Pre-Senile Cataracts Completed NCT00067483
11 Assessment of Vision-related Quality of Life (VRQOL) in Cataract Patients During the COVID-19 Pandemic Recruiting NCT04468308
12 Subclinical Sympathetic Response Related to Second-eye Pain in Cataract Surgery and Its Noninvasive Detection Index Not yet recruiting NCT03766230

Search NIH Clinical Center for Senile Cataract

Genetic Tests for Senile Cataract

Anatomical Context for Senile Cataract

MalaCards organs/tissues related to Senile Cataract:

40
Eye, Endothelial, Retina, Salivary Gland, Cortex, Smooth Muscle

Publications for Senile Cataract

Articles related to Senile Cataract:

(show top 50) (show all 1341)
# Title Authors PMID Year
1
Glucose-6-phosphate dehydrogenase (G6PD) deficiency and senile cataract in a Sardinian male population, Italy. 61 54
19995205 2009
2
The evaluation of the oxidative stress parameters in nondiabetic and diabetic senile cataract patients. 54 61
18982249 2009
3
Implication of glutathione S-transferase M1 and T1 polymorphisms in the development of senile cataract among Egyptians. 61 54
20120433 2009
4
Activity of superoxide dismutase obtained from senile cataract lens - effect of diabetes mellitus. 61 54
19093039 2008
5
Role of anti-oxidant enzymes superoxide dismutase and catalase in the development of cataract : study of serum levels in patients with senile and diabetic cataracts. 61 54
17240813 2006
6
Decreased glucose-6-phosphate-dehydrogenase (G6PD) activity and risk of senile cataract in Taiwan. 54 61
16581614 2006
7
Erythrocyte antioxidant enzymes in patients with cataract. 54 61
16682518 2006
8
Downregulation of gene expression in the ageing lens: a possible contributory factor in senile cataract. 54 61
15105821 2005
9
Changes in glutathione, glutathione-linked enzymes and hexose monophosphate shunt enzymes in senile cataract. 61 54
15255623 2003
10
[The study on superoxide dismutase and trace element in patients with senile cataract]. 54 61
12579780 2000
11
Polymorphic glutathione S-transferases as genetic risk factors for senile cortical cataract in Estonians. 61 54
10892871 2000
12
[Relationship between GSTM1 genotype and susceptibility to senile cataract]. 61 54
11835784 1999
13
The study of G6PD in erythrocyte and lens in senile and presenile cataract. 61 54
1286674 1992
14
Senile cataract and glucose-6-phosphate dehydrogenase deficiency in Indians. 61 54
2100077 1990
15
Proteomic analysis of aqueous humor from cataract patients with retinitis pigmentosa. 61
32869287 2021
16
Potential Protective Activities of Extracts of Phellinus linteus and the Altered Expressions of GSTM3 on Age-Related Cataract. 61
33542742 2021
17
The impact of visual axis position on the optical quality after implantation of multifocal intraocular lenses with different asphericity values. 61
33471202 2021
18
Hemodynamics of the temporal and nasal short posterior ciliary arteries in pseudoexfoliation syndrome. 61
32935253 2021
19
Femtosecond laser-assisted cataract surgery in eyes with shallow anterior chamber depth: comparison with conventional phacoemulsification. 61
32932370 2020
20
Biogeographical and Altitudinal Distribution of Cataract: A Nine-Year Experience Using Electronic Medical Record-Driven Big Data Analytics in India. 61
33213243 2020
21
Long-Lasting Thrombocytopenia and Senile Cataract. 61
32542376 2020
22
Higher Aqueous Levels of Resistin and Lipocalin-2 Indicated Worse Visual Improvement following anti-VEGF Therapy in Patients with Retinal Vein Occlusion. 61
33103481 2020
23
Hepatic encephalopathy increases the risk of hip fracture: a nationwide cohort study. 61
33243187 2020
24
Changes in visual function and quality of life in patients with senile cataract following phacoemulsification. 61
33183034 2020
25
Femtosecond laser-assisted refractive capsulorhexis - Precise capsulotomy with accurate toric intraocular lens alignment. 61
33120692 2020
26
Minimizing surgically induced astigmatism in non-phaco manual small incision cataract surgery by U-shaped modification of scleral incision. 61
32971618 2020
27
Comparison of inflammatory cytokines levels in the aqueous humor with diabetic retinopathy. 61
32556740 2020
28
Association of Serum Magnesium with Oxidative Stress in the Pathogenesis of Diabetic Cataract. 61
33037494 2020
29
Intralenticular changes in eyes with mature senile cataract on modified posterior segment optical coherence tomography. 61
32971616 2020
30
Molecular signature for senile and complicated cataracts derived from analysis of sumoylation enzymes and their substrates in human cataract lenses. 61
32827359 2020
31
Bullous central serous chorioretinopathy and retinal pigment epithelium sequelae postblunt trauma. 61
32967945 2020
32
[The analysis of concomitant pathology in ophthalmologic practice based on electronic medical records data]. 61
33161660 2020
33
Polyamine Oxidase Is Involved in Spermidine Reduction of Transglutaminase Type 2-Catalyzed βH-Crystallins Polymerization in Calcium-Induced Experimental Cataract. 61
32751462 2020
34
Dry Eye Disease after Cataract Surgery: Study of its Determinants and Risk Factors 61
32630999 2020
35
Lens epithelial surface disorders in exfoliation syndrome: a scanning and transmission electron microscopy study. 61
32403107 2020
36
Phacoemulsification Induced Changes of Choroidal Thickness in Eyes with Age-Related Macular Degeneration. 61
32455884 2020
37
Nutrition knowledge and dietary patterns in ophthalmic patients. 61
32363741 2020
38
Posterior capsule opacification and Nd:YAG laser rates with two hydrophobic acrylic single-piece IOLs. 61
31485039 2020
39
Comparative clinical trial of intracameral ropivacaine vs. lignocaine in subjects undergoing phacoemulsification under augmented topical anesthesia. 61
32174572 2020
40
Prevalence of diabetes and diabetic macular edema in patients undergoing senile cataract surgery in Italy: The DIabetes and CATaract study. 61
30854895 2020
41
Frequency of Corneal Astigmatism in Patients Presenting for Senile Cataract Surgery at a Teaching Hospital in Indian Rural Population. 61
31923034 2020
42
Pigment epithelial-derived factor in the lens anterior capsule of patients with senile cataract with pseudoexfoliation. 61
31090113 2020
43
Suction Break During Femtosecond Laser-Assisted Cataract Surgery and Misplaced Laser Beam Delivery to the Corneal Layers. 61
33235519 2020
44
A Preliminary Comparative Study of Visual Performance Between Two Newly Commercially Available Monofocal Intraocular Lenses Implanted During Cataract Surgery. 61
32214794 2020
45
Is Dietary Milk Intake Associated with Cataract Extraction History in Older Adults? An Analysis from the US Population. 61
32148937 2020
46
Social impact indicators in patient diagnosed of senile cataract treated with phacoemulsification plus intraocular lens implantation. 61
32538985 2020
47
Aqueous cytokine levels in four common uveitis entities. 61
31776091 2020
48
Evaluation of Nd:YAG Laser Capsulotomy Rates in a Real-Life Population. 61
33116375 2020
49
Aqueous humor and serum 25-Hydroxyvitamin D levels in patients with cataracts. 61
31906919 2020
50
Ease of Hydrodissection during Phacoemulsification: A Comparison between Patients with and Those without Exfoliation Syndrome. 61
32163946 2020

Variations for Senile Cataract

Expression for Senile Cataract

Search GEO for disease gene expression data for Senile Cataract.

Pathways for Senile Cataract

GO Terms for Senile Cataract

Cellular components related to Senile Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.28 TALDO1 SOD1 SERPINF1 GSTT1 GSR GALK1

Biological processes related to Senile Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.73 XRCC1 SOD1 OGG1 APEX1
2 response to oxidative stress GO:0006979 9.65 WRN SOD1 OGG1
3 response to ethanol GO:0045471 9.63 SOD1 OGG1 G6PD
4 carbohydrate metabolic process GO:0005975 9.62 TALDO1 GALK1 G6PD CS
5 cellular response to oxidative stress GO:0034599 9.58 SOD1 GSR G6PD
6 aging GO:0007568 9.55 WRN SOD1 SERPINF1 OGG1 APEX1
7 cellular oxidant detoxification GO:0098869 9.43 GSTT1 GSR ALB
8 pentose-phosphate shunt GO:0006098 9.37 TALDO1 G6PD
9 base-excision repair GO:0006284 9.26 XRCC1 WRN OGG1 APEX1
10 glutathione metabolic process GO:0006749 9.02 SOD1 GSTT1 GSTM1 GSR G6PD

Molecular functions related to Senile Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 damaged DNA binding GO:0003684 9.13 XRCC1 OGG1 APEX1
2 structural constituent of eye lens GO:0005212 8.8 CRYGS CRYAA BFSP1

Sources for Senile Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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