MCID: SNL004
MIFTS: 28

Senile Ectropion

Categories: Skin diseases

Aliases & Classifications for Senile Ectropion

MalaCards integrated aliases for Senile Ectropion:

Name: Senile Ectropion 12 15 71
Involutional Ectropion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13356
ICD9CM 34 374.11
SNOMED-CT 67 71659009
UMLS 71 C0155193

Summaries for Senile Ectropion

MalaCards based summary : Senile Ectropion, also known as involutional ectropion, is related to spastic entropion and ectropion. An important gene associated with Senile Ectropion is MMP7 (Matrix Metallopeptidase 7), and among its related pathways/superpathways are Degradation of the extracellular matrix and CLEC7A (Dectin-1) signaling. Affiliated tissues include eye, and related phenotypes are neoplasm and vision/eye

Related Diseases for Senile Ectropion

Diseases related to Senile Ectropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 spastic entropion 29.9 MMP9 MMP7 MMP2
2 ectropion 10.6
3 mid-dermal elastolysis 10.3 MMP7 ELN
4 cerebral aneurysms 10.3 MMP2 ELN
5 entropion 10.3
6 osteopoikilosis 10.2 LMNA ELN
7 buschke-ollendorff syndrome 10.2 LMNA ELN
8 ovarian cystadenoma 10.2 MUC16 LMNA
9 astigmatism 10.2
10 chronic actinic dermatitis 10.2 MMP9 ELN
11 pediatric multiple sclerosis 10.2 MMP9 MMP7
12 extracranial arteriovenous malformation 10.2 MMP9 MMP2
13 acute transverse myelitis 10.2 MMP9 MMP2
14 transverse myelitis 10.2 MMP9 MMP2
15 lentigo maligna melanoma 10.2 MMP9 MMP2
16 nasal cavity squamous cell carcinoma 10.1 MMP9 MMP2
17 brain glioblastoma multiforme 10.1 MMP9 MMP7
18 struma ovarii 10.1 TSHR MUC16
19 odontogenic myxoma 10.1 MMP9 MMP2
20 nasal cavity benign neoplasm 10.1 MMP9 MMP2
21 prolapse of urethra 10.1 MMP9 ELN
22 myxedema 10.1 TSHR MUC16
23 parotitis 10.1 MMP9 MMP2
24 periapical periodontitis 10.1 MMP9 MMP2
25 miliary tuberculosis 10.1 PDCD1 MUC16
26 conjunctivochalasis 10.1 MMP9 MMP2
27 dental fluorosis 10.1 MMP9 MMP2
28 ischemic colitis 10.1 MMP9 MMP2
29 lung giant cell carcinoma 10.1 MMP9 MMP2
30 atopic keratoconjunctivitis 10.1 MUC5AC MUC16
31 cap polyposis 10.1 MUC5AC MUC4
32 punctate epithelial keratoconjunctivitis 10.1 MUC5AC MUC16
33 chronic ethmoiditis 10.1 MUC5AC MUC4
34 bile duct mucinous adenocarcinoma 10.1 MUC5AC MUC4
35 colorectal cancer, hereditary nonpolyposis, type 8 10.1 MUC5AC MUC16
36 bile duct mucoepidermoid carcinoma 10.1 MUC5AC MUC4
37 limbal stem cell deficiency 10.0 MUC5AC MUC4
38 keratitis, hereditary 10.0
39 enophthalmos 10.0
40 arteriosclerosis 10.0
41 basal cell carcinoma 10.0
42 septic arthritis 10.0 MMP7 MMP2
43 focal myositis 10.0 MMP9 MMP7 MMP2
44 eyelid disease 10.0 MUC16 MMP9
45 light chain deposition disease 10.0 MMP9 MMP7 MMP2
46 gastroesophageal junction adenocarcinoma 10.0 PDCD1 MMP9
47 pelvic organ prolapse 10.0 MMP9 MMP2 ELN
48 pulmonary emphysema 10.0 MMP9 MMP2 ELN
49 aortic aneurysm, familial thoracic 1 10.0 MMP9 MMP2 ELN
50 aortic aneurysm 10.0 MMP9 MMP2 ELN

Graphical network of the top 20 diseases related to Senile Ectropion:



Diseases related to Senile Ectropion

Symptoms & Phenotypes for Senile Ectropion

MGI Mouse Phenotypes related to Senile Ectropion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.35 MMP2 MMP7 MMP9 PDCD1 TSHR
2 vision/eye MP:0005391 9.17 LMNA MMP2 MMP7 MMP9 MUC5AC PDCD1

Drugs & Therapeutics for Senile Ectropion

Search Clinical Trials , NIH Clinical Center for Senile Ectropion

Genetic Tests for Senile Ectropion

Anatomical Context for Senile Ectropion

MalaCards organs/tissues related to Senile Ectropion:

40
Eye

Publications for Senile Ectropion

Articles related to Senile Ectropion:

(show top 50) (show all 74)
# Title Authors PMID Year
1
A New Surgical Method for Medial Ectropion Repair: Fixing the Lower Eyelid Retractor to the Back of the Tarsal Plate. 61
32858610 2021
2
Lower Eyelid Distraction Test: New Insights on the Reference Value. 61
30969191 2019
3
Vector analysis of changes in corneal astigmatism following lateral tarsal strip procedure in patients with involutional ectropion or entropion. 61
30054850 2019
4
A quantitative analysis of factors influencing lower lid retraction and involutional ectropion. 61
30467002 2019
5
The Use of a Double Suture and Conjunctival Cuts in the Lateral Tarsal Strip: A New Approach to Involutional Ectropion. 61
30320676 2018
6
Lateral tarsal strip versus lateral tarsal strip with three-snip punctoplasty for managing epiphora in involutional ectropion. 61
30217604 2018
7
"The influence of orbital vector on involutional entropion and ectropion". 61
28853964 2018
8
Vertical Midface Lifting with Periorbital Anchoring in the Management of Lower Eyelid Retraction: A 10-Year Clinical Retrospective Study. 61
28338588 2017
9
Comparison of Polypropylene Sling with Combined Transconjunctival Retractor Plication and Lateral Tarsal Strip for Correction of Involutional Lower Eye Lid Ectropion. 61
29081868 2017
10
Alberto Urrets-Zavalía Jr (1920-2010): An Argentinian contributor to ophthalmology. 61
24833540 2016
11
Eyelid aging: pathophysiology and clinical management. 61
26466237 2015
12
Re: "Lower eyelid involutional ectropion repair with lateral tarsal strip and internal retractor reattachment with full-thickness eyelid sutures". 61
25945875 2015
13
[Keratopathy versus allergic eye disease: misdiagnosis leading to keratitis]. 61
25497650 2014
14
Lower eyelid involutional ectropion repair with lateral tarsal strip and internal retractor reattachment with full-thickness eyelid sutures. 61
25025386 2014
15
Surgical preferences for lateral canthoplasty and canthopexy. 61
25050757 2014
16
Age-matched, case-controlled comparison of clinical indicators for development of entropion and ectropion. 61
24734167 2014
17
Topical rebamipide improves the ocular surface in mild lagophthalmos. 61
23836962 2013
18
The lateral tarsal strip in ectropion surgery: is it effective when performed in isolation? 61
22402697 2012
19
Marked bilateral lower eyelid ectropion in cutis laxa: a paraneoplastic process in multiple myeloma. 61
22551370 2012
20
Involutional entropion and ectropion of the lower eyelid: prevalence and associated risk factors in the elderly population. 61
21415800 2011
21
Involutional ectropion and entropion: clinicopathologic correlation between horizontal eyelid laxity and eyelid extracellular matrix. 61
21490515 2011
22
Pathogenesis of involutional ectropion and entropion: the involvement of matrix metalloproteinases in elastic fiber degradation. 61
21574802 2011
23
Lateral canthoplasty by the Micro-Mitek Anchor System: 10-year review of 96 patients. 61
21277065 2011
24
Our approach to operative treatment of lower lid ectropion. 61
21462817 2010
25
Ectropion. 61
20590414 2010
26
[Challenges in the surgical correction of complicated ectropion cases]. 61
20091445 2010
27
The histopathology of involutional ectropion and entropion. 61
20029486 2009
28
Entropion-ectropion: the influence of axial globe projection on lower eyelid malposition. 61
19273913 2009
29
Midface lifting as an adjunct procedure in ectropion repair. 61
18046143 2007
30
Management of lower lid ectropion. 61
16918568 2006
31
The not-so-lazy-T: a modification of medial ectropion repair. 61
16623164 2006
32
Lateral canthoplasty--10-year experience. 61
17165595 2006
33
Corneal topography in involutional ectropion of the lower eyelid: preoperative and postoperative evaluation. 61
15829800 2005
34
[Surgery for involutional ectropion--case report]. 61
14552181 2003
35
Role of the lower lid retractors in involutional ectropion repair. 61
12045919 2001
36
Causes of involutional ectropion and entropion--age-related tarsal changes are the key. 61
10749160 2000
37
Involutional entropion and ectropion of the Asian lower eyelid. 61
10674733 2000
38
The role of enophthalmos in the development of involutional ectropion. 61
12048692 1999
39
[Ocular manifestations in progeria]. 61
7539290 1995
40
[Surgery of advanced atonic senile ectropion]. 61
8051879 1994
41
Histochemical staining of orbicularis oculi muscle in ectropion and entropion. 61
7958041 1994
42
[Tarsal flap technique. A technically simple procedure for correction of lower lid flaccidity, senile ectropion and ptosis of the lateral canthus]. 61
8231042 1993
43
Secondary dye testing of the lacrimal system. 61
8446360 1993
44
[Senile ectropion and entropion]. 61
1568673 1992
45
The "no flap" technique for lower-lid blepharoplasty. 61
1570778 1992
46
[The aging eyelid]. 61
2255834 1990
47
The tight retracted lower eyelid. 61
2310348 1990
48
Senile ectropion. 61
3347680 1988
49
Involutional ectropion: a review of the management. 61
3554087 1987
50
Ocular leprosy: a case report and discussion of the pathology. 61
3964481 1986

Variations for Senile Ectropion

Expression for Senile Ectropion

Search GEO for disease gene expression data for Senile Ectropion.

Pathways for Senile Ectropion

Pathways related to Senile Ectropion according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.41 MMP9 MMP7 MMP2 ELN
2
Show member pathways
12.16 MUC5AC MUC4 MUC16
3
Show member pathways
11.96 MUC5AC MUC4 MUC16
4 11.89 MMP9 MMP7 MMP2
5
Show member pathways
11.82 MUC5AC MUC4 MUC16
6 11.67 TJP1 MMP9 MMP2
7
Show member pathways
11.58 MUC5AC MUC4 MUC16
8
Show member pathways
11.49 MMP9 MMP7 MMP2
9 11.38 MMP9 MMP7 MMP2
10 11.16 MMP9 ELN
11 11.15 MMP9 MMP7 MMP2
12 11.09 MMP9 MMP2
13 11.05 MMP9 MMP2
14 10.95 MMP9 MMP2
15 10.93 MMP9 MMP2 ELN
16 10.87 MMP9 MMP2
17 10.66 MMP9 MMP7
18 10.58 MMP9 MMP7 MMP2

GO Terms for Senile Ectropion

Cellular components related to Senile Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 MUC5AC MUC4 MUC16 MMP9 MMP7 MMP2
2 extracellular region GO:0005576 9.7 MUC5AC MUC4 MUC16 MMP9 MMP7 MMP2
3 Golgi lumen GO:0005796 9.13 MUC5AC MUC4 MUC16
4 extracellular matrix GO:0031012 9.1 MUC5AC MUC4 MMP9 MMP7 MMP2 ELN

Biological processes related to Senile Ectropion according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.67 TJP1 MMP9 MMP7
2 extracellular matrix organization GO:0030198 9.56 MMP9 MMP7 MMP2 ELN
3 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.54 MUC5AC MUC4 MUC16
4 cellular response to reactive oxygen species GO:0034614 9.48 MMP9 MMP2
5 embryo implantation GO:0007566 9.46 MMP9 MMP2
6 endodermal cell differentiation GO:0035987 9.43 MMP9 MMP2
7 response to amyloid-beta GO:1904645 9.4 MMP9 MMP2
8 extracellular matrix disassembly GO:0022617 9.33 MMP9 MMP7 MMP2
9 cellular response to UV-A GO:0071492 9.32 MMP9 MMP2
10 O-glycan processing GO:0016266 9.13 MUC5AC MUC4 MUC16
11 collagen catabolic process GO:0030574 8.8 MMP9 MMP7 MMP2

Molecular functions related to Senile Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.43 MMP9 MMP7 MMP2
2 metallopeptidase activity GO:0008237 9.33 MMP9 MMP7 MMP2
3 metalloendopeptidase activity GO:0004222 9.13 MMP9 MMP7 MMP2
4 endopeptidase activity GO:0004175 8.8 MMP9 MMP7 MMP2

Sources for Senile Ectropion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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