MCID: SNL004
MIFTS: 30

Senile Ectropion

Categories: Eye diseases

Aliases & Classifications for Senile Ectropion

MalaCards integrated aliases for Senile Ectropion:

Name: Senile Ectropion 12 15 73
Involutional Ectropion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13356
ICD9CM 35 374.11
SNOMED-CT 68 71659009
UMLS 73 C0155193

Summaries for Senile Ectropion

MalaCards based summary : Senile Ectropion, also known as involutional ectropion, is related to ectropion and entropion. An important gene associated with Senile Ectropion is DNAAF3 (Dynein Axonemal Assembly Factor 3), and among its related pathways/superpathways are Degradation of the extracellular matrix and Proteoglycans in cancer. Affiliated tissues include eye, skin and brain, and related phenotype is cardiovascular system.

Related Diseases for Senile Ectropion

Diseases related to Senile Ectropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 ectropion 10.5
2 entropion 10.2
3 elephantiasis 10.2 ELN SRCIN1
4 intestinal volvulus 10.1 SRCIN1 TWIST1
5 paraphimosis 10.1 KANTR SRCIN1
6 mid-dermal elastolysis 10.1 ELN MMP7
7 optic disk drusen 10.1 ELN KANTR
8 punctate epithelial keratoconjunctivitis 10.1 KANTR SRCIN1
9 cerebral aneurysms 10.1 ELN MMP2
10 hemidystonia 10.1 KANTR TWIST1
11 sorsby fundus dystrophy 10.0 ELN MMP2
12 hypertelorism 10.0 ELN TWIST1
13 astigmatism 10.0
14 enophthalmos 10.0
15 apical myocardial infarction 10.0 KANTR MMP2
16 bowen's disease 10.0
17 intracranial aneurysm 10.0 ELN MMP2
18 chronic actinic dermatitis 10.0 ELN MMP9
19 cerebral arterial disease 10.0 ELN MMP9
20 marfan syndrome 10.0 ELN MMP2
21 pelvic organ prolapse 9.9 ELN MMP9
22 brain glioblastoma multiforme 9.9 MMP7 MMP9
23 pediatric multiple sclerosis 9.9 MMP7 MMP9
24 adult astrocytic tumour 9.9 MMP7 MMP9
25 pulmonary emphysema 9.9 ELN MMP9
26 lymphangioleiomyomatosis 9.9 ELN MMP2
27 extracranial arteriovenous malformation 9.9 MMP2 MMP9
28 villous adenocarcinoma 9.9 MMP2 MMP9
29 lentigo maligna melanoma 9.9 MMP2 MMP9
30 psammomatous meningioma 9.9 MMP2 MMP9
31 acute transverse myelitis 9.9 MMP2 MMP9
32 transverse myelitis 9.9 MMP2 MMP9
33 ischemic colitis 9.9 MMP2 MMP9
34 conjunctival nevus 9.9 MMP2 MMP9
35 parotitis 9.9 MMP2 MMP9
36 klatskin's tumor 9.9 MMP2 MMP9
37 corneal ulcer 9.9 MMP2 MMP9
38 nasal cavity squamous cell carcinoma 9.9 MMP2 MMP9
39 odontogenic myxoma 9.9 MMP2 MMP9
40 laryngeal disease 9.9 MMP2 MMP9
41 hypertensive heart disease 9.9 MMP2 MMP9
42 adenomyosis 9.9 MMP2 MMP9
43 grade iii astrocytoma 9.8 MMP2 MMP9
44 skin melanoma 9.8 MMP2 MMP9
45 tongue cancer 9.8 MMP2 MMP9
46 oral cancer 9.8 MMP2 MMP9
47 aortic aneurysm, familial thoracic 1 9.8 ELN MMP2 MMP9
48 pneumothorax 9.8 ELN MMP2 MMP9
49 aortic disease 9.8 ELN MMP2 MMP9
50 inguinal hernia 9.8 ELN MMP2 MMP9

Graphical network of the top 20 diseases related to Senile Ectropion:



Diseases related to Senile Ectropion

Symptoms & Phenotypes for Senile Ectropion

MGI Mouse Phenotypes related to Senile Ectropion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.1 DNAAF3 MMP2 MMP7 MMP9 SRCIN1 TWIST1

Drugs & Therapeutics for Senile Ectropion

Search Clinical Trials , NIH Clinical Center for Senile Ectropion

Genetic Tests for Senile Ectropion

Anatomical Context for Senile Ectropion

MalaCards organs/tissues related to Senile Ectropion:

41
Eye, Skin, Brain, Heart, Tongue

Publications for Senile Ectropion

Articles related to Senile Ectropion:

(show all 13)
# Title Authors Year
1
Vector analysis of changes in corneal astigmatism following lateral tarsal strip procedure in patients with involutional ectropion or entropion. ( 30054850 )
2018
2
Lateral tarsal strip versus lateral tarsal strip with three-snip punctoplasty for managing epiphora in involutional ectropion. ( 30217604 )
2018
3
The Use of a Double Suture and Conjunctival Cuts in the Lateral Tarsal Strip: A New Approach to Involutional Ectropion. ( 30320676 )
2018
4
A quantitative analysis of factors influencing lower lid retraction and involutional ectropion. ( 30467002 )
2018
5
Senile ectropion. ( 3347680 )
1988
6
Senile ectropion. ( 974868 )
1976
7
Senile ectropion and entropion: a comparative histopathological study. ( 57735 )
1976
8
Surgery of senile ectropion and entropion. ( 5012696 )
1972
9
Senile ectropion. ( 13959048 )
1962
10
V-Z procedure for the correction of senile ectropion. ( 13840478 )
1959
11
Senile ectropion: analysis of types and surgical correction. ( 13207288 )
1954
12
Senile ectropion and Bowen's disease. ( 21066076 )
1946
13
SUBCUTANEOUS SPLITTING OF THE LID IN THE OPERATIVE TREATMENT OF SENILE ECTROPION*. ( 18170136 )
1945

Variations for Senile Ectropion

Expression for Senile Ectropion

Search GEO for disease gene expression data for Senile Ectropion.

Pathways for Senile Ectropion

Pathways related to Senile Ectropion according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.39 ELN MMP2 MMP7 MMP9
2 12.02 MMP2 MMP9 TWIST1
3
Show member pathways
11.92 ELN MMP2 MMP7 MMP9
4 11.89 MMP2 MMP7 MMP9
5
Show member pathways
11.73 MMP2 MMP7 MMP9
6 11.67 MMP2 MMP9 SRCIN1
7 11.6 MMP2 MMP9 TWIST1
8
Show member pathways
11.49 MMP2 MMP7 MMP9
9 11.47 MMP2 MMP9
10 11.42 MMP2 MMP9
11
Show member pathways
11.4 MMP2 MMP9
12 11.38 MMP2 MMP7 MMP9
13 11.27 MMP2 MMP9
14
Show member pathways
11.24 MMP2 MMP9
15 11.17 ELN MMP9
16 11.15 MMP2 MMP7 MMP9
17 11.1 MMP2 MMP9
18 11.06 MMP2 MMP9
19 10.96 MMP2 MMP9
20 10.93 ELN MMP2 MMP9
21 10.89 MMP2 MMP9
22 10.71 MMP7 MMP9
23 10.58 MMP2 MMP7 MMP9

GO Terms for Senile Ectropion

Cellular components related to Senile Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.13 ELN MMP2 MMP9
2 extracellular matrix GO:0031012 8.92 ELN MMP2 MMP7 MMP9

Biological processes related to Senile Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.54 MMP2 MMP9 TWIST1
2 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.4 MMP2 MMP9
3 embryo implantation GO:0007566 9.32 MMP2 MMP9
4 endodermal cell differentiation GO:0035987 9.26 MMP2 MMP9
5 aortic valve morphogenesis GO:0003180 9.16 ELN TWIST1
6 extracellular matrix disassembly GO:0022617 9.13 MMP2 MMP7 MMP9
7 collagen catabolic process GO:0030574 8.8 MMP2 MMP7 MMP9

Molecular functions related to Senile Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.33 MMP2 MMP7 MMP9
2 metallopeptidase activity GO:0008237 9.13 MMP2 MMP7 MMP9
3 metalloendopeptidase activity GO:0004222 8.8 MMP2 MMP7 MMP9

Sources for Senile Ectropion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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