MCID: SNL004
MIFTS: 29

Senile Ectropion

Categories: Eye diseases

Aliases & Classifications for Senile Ectropion

MalaCards integrated aliases for Senile Ectropion:

Name: Senile Ectropion 12 15 71
Involutional Ectropion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13356
ICD9CM 34 374.11
SNOMED-CT 67 71659009
UMLS 71 C0155193

Summaries for Senile Ectropion

MalaCards based summary : Senile Ectropion, also known as involutional ectropion, is related to entropion and lagophthalmos. An important gene associated with Senile Ectropion is LAX1 (Lymphocyte Transmembrane Adaptor 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Cytoskeletal Signaling. Affiliated tissues include eye, lung and testes, and related phenotypes are Reduced mammosphere formation and cardiovascular system

Related Diseases for Senile Ectropion

Diseases related to Senile Ectropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 entropion 30.8 SRCIN1 LAX1 DCXR
2 lagophthalmos 30.5 LAX1 DCXR
3 spastic entropion 30.1 MMP9 MMP7 MMP2
4 senile entropion 29.3 LAX1 FLNA FHL1 DCXR
5 ectropion 10.6
6 blepharochalasis 10.4 LAX1 ELN
7 mid-dermal elastolysis 10.4 MMP7 ELN
8 x-linked emery-dreifuss muscular dystrophy 10.4 LMNA FHL1
9 bladder diverticulum 10.4 LAX1 ELN
10 cerebral aneurysms 10.4 MMP2 ELN
11 punctate epithelial keratoconjunctivitis 10.3 SRCIN1 MUC16
12 volvulus of midgut 10.3 SRCIN1 LAX1
13 phimosis 10.3 LAX1 ELN
14 internal hordeolum 10.3 SRCIN1 DCXR
15 emery-dreifuss muscular dystrophy 7, autosomal dominant 10.3 LMNA FHL1
16 chronic actinic dermatitis 10.2 MMP9 ELN
17 elephantiasis 10.2 SRCIN1 ELN
18 angioid streaks 10.2 LAX1 ELN
19 extracranial arteriovenous malformation 10.2 MMP9 MMP2
20 pediatric multiple sclerosis 10.2 MMP9 MMP7
21 cicatricial ectropion 10.2 SRCIN1 LAX1 DCXR
22 astigmatism 10.2
23 excessive tearing 10.2 SRCIN1 LAX1 DCXR
24 lentigo maligna melanoma 10.2 MMP9 MMP2
25 acute transverse myelitis 10.2 MMP9 MMP2
26 transverse myelitis 10.2 MMP9 MMP2
27 filamentary keratitis 10.2 MUC4 MUC16
28 nasal cavity squamous cell carcinoma 10.2 MMP9 MMP2
29 cicatricial entropion 10.1 LAX1 FHL1 DCXR
30 odontogenic myxoma 10.1 MMP9 MMP2
31 brain glioblastoma multiforme 10.1 MMP9 MMP7
32 prolapse of urethra 10.1 MMP9 ELN
33 parotitis 10.1 MMP9 MMP2
34 mixed cell uveal melanoma 10.1 MMP9 MMP2
35 ovarian cystadenoma 10.1 MUC16 LMNA
36 atopic keratoconjunctivitis 10.1 MUC5AC MUC16
37 keratitis, hereditary 10.0
38 enophthalmos 10.0
39 arteriosclerosis 10.0
40 basal cell carcinoma 10.0
41 cap polyposis 10.0 MUC5AC MUC4
42 ptosis 10.0
43 paralytic lagophthalmos 10.0
44 bowen's disease 10.0
45 hypotonia 10.0
46 bile duct mucinous adenocarcinoma 10.0 MUC5AC MUC4
47 focal myositis 10.0 MMP9 MMP7 MMP2
48 light chain deposition disease 10.0 MMP9 MMP7 MMP2
49 colorectal cancer, hereditary nonpolyposis, type 8 10.0 MUC5AC MUC16
50 bile duct mucoepidermoid carcinoma 10.0 MUC5AC MUC4

Graphical network of the top 20 diseases related to Senile Ectropion:



Diseases related to Senile Ectropion

Symptoms & Phenotypes for Senile Ectropion

GenomeRNAi Phenotypes related to Senile Ectropion according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 DCXR FLNA LMNA MMP2 MMP7 MUC5AC

MGI Mouse Phenotypes related to Senile Ectropion:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.32 DCXR DNAAF3 FHL1 FLNA LMNA MMP2

Drugs & Therapeutics for Senile Ectropion

Search Clinical Trials , NIH Clinical Center for Senile Ectropion

Genetic Tests for Senile Ectropion

Anatomical Context for Senile Ectropion

MalaCards organs/tissues related to Senile Ectropion:

40
Eye, Lung, Testes, Brain

Publications for Senile Ectropion

Articles related to Senile Ectropion:

(show top 50) (show all 71)
# Title Authors PMID Year
1
Lower Eyelid Distraction Test: New Insights on the Reference Value. 61
30969191 2019
2
Vector analysis of changes in corneal astigmatism following lateral tarsal strip procedure in patients with involutional ectropion or entropion. 61
30054850 2019
3
A quantitative analysis of factors influencing lower lid retraction and involutional ectropion. 61
30467002 2019
4
The Use of a Double Suture and Conjunctival Cuts in the Lateral Tarsal Strip: A New Approach to Involutional Ectropion. 61
30320676 2018
5
Lateral tarsal strip versus lateral tarsal strip with three-snip punctoplasty for managing epiphora in involutional ectropion. 61
30217604 2018
6
"The influence of orbital vector on involutional entropion and ectropion". 61
28853964 2018
7
Vertical Midface Lifting with Periorbital Anchoring in the Management of Lower Eyelid Retraction: A 10-Year Clinical Retrospective Study. 61
28338588 2017
8
Comparison of Polypropylene Sling with Combined Transconjunctival Retractor Plication and Lateral Tarsal Strip for Correction of Involutional Lower Eye Lid Ectropion. 61
29081868 2017
9
Alberto Urrets-Zavalía Jr (1920-2010): An Argentinian contributor to ophthalmology. 61
24833540 2016
10
Eyelid aging: pathophysiology and clinical management. 61
26466237 2015
11
Re: "Lower eyelid involutional ectropion repair with lateral tarsal strip and internal retractor reattachment with full-thickness eyelid sutures". 61
25945875 2015
12
[Keratopathy versus allergic eye disease: misdiagnosis leading to keratitis]. 61
25497650 2014
13
Lower eyelid involutional ectropion repair with lateral tarsal strip and internal retractor reattachment with full-thickness eyelid sutures. 61
25025386 2014
14
Surgical preferences for lateral canthoplasty and canthopexy. 61
25050757 2014
15
Age-matched, case-controlled comparison of clinical indicators for development of entropion and ectropion. 61
24734167 2014
16
Topical rebamipide improves the ocular surface in mild lagophthalmos. 61
23836962 2013
17
Marked bilateral lower eyelid ectropion in cutis laxa: a paraneoplastic process in multiple myeloma. 61
22551370 2012
18
The lateral tarsal strip in ectropion surgery: is it effective when performed in isolation? 61
22402697 2012
19
Involutional entropion and ectropion of the lower eyelid: prevalence and associated risk factors in the elderly population. 61
21415800 2011
20
Involutional ectropion and entropion: clinicopathologic correlation between horizontal eyelid laxity and eyelid extracellular matrix. 61
21490515 2011
21
Pathogenesis of involutional ectropion and entropion: the involvement of matrix metalloproteinases in elastic fiber degradation. 61
21574802 2011
22
Lateral canthoplasty by the Micro-Mitek Anchor System: 10-year review of 96 patients. 61
21277065 2011
23
Our approach to operative treatment of lower lid ectropion. 61
21462817 2010
24
Ectropion. 61
20590414 2010
25
[Challenges in the surgical correction of complicated ectropion cases]. 61
20091445 2010
26
The histopathology of involutional ectropion and entropion. 61
20029486 2009
27
Entropion-ectropion: the influence of axial globe projection on lower eyelid malposition. 61
19273913 2009
28
Midface lifting as an adjunct procedure in ectropion repair. 61
18046143 2007
29
Management of lower lid ectropion. 61
16918568 2006
30
The not-so-lazy-T: a modification of medial ectropion repair. 61
16623164 2006
31
Lateral canthoplasty--10-year experience. 61
17165595 2006
32
Corneal topography in involutional ectropion of the lower eyelid: preoperative and postoperative evaluation. 61
15829800 2005
33
[Surgery for involutional ectropion--case report]. 61
14552181 2003
34
Role of the lower lid retractors in involutional ectropion repair. 61
12045919 2001
35
Causes of involutional ectropion and entropion--age-related tarsal changes are the key. 61
10749160 2000
36
Involutional entropion and ectropion of the Asian lower eyelid. 61
10674733 2000
37
The role of enophthalmos in the development of involutional ectropion. 61
12048692 1999
38
[Ocular manifestations in progeria]. 61
7539290 1995
39
[Surgery of advanced atonic senile ectropion]. 61
8051879 1994
40
Histochemical staining of orbicularis oculi muscle in ectropion and entropion. 61
7958041 1994
41
[Tarsal flap technique. A technically simple procedure for correction of lower lid flaccidity, senile ectropion and ptosis of the lateral canthus]. 61
8231042 1993
42
Secondary dye testing of the lacrimal system. 61
8446360 1993
43
[Senile ectropion and entropion]. 61
1568673 1992
44
The "no flap" technique for lower-lid blepharoplasty. 61
1570778 1992
45
[The aging eyelid]. 61
2255834 1990
46
The tight retracted lower eyelid. 61
2310348 1990
47
Senile ectropion. 61
3347680 1988
48
Involutional ectropion: a review of the management. 61
3554087 1987
49
Ocular leprosy: a case report and discussion of the pathology. 61
3964481 1986
50
History of surgery for involutional ectropion. 61
3331928 1986

Variations for Senile Ectropion

Expression for Senile Ectropion

Search GEO for disease gene expression data for Senile Ectropion.

Pathways for Senile Ectropion

Pathways related to Senile Ectropion according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.49 MMP9 MMP7 MMP2 ELN
2 12.19 TJP1 SRCIN1 LMNA FLNA
3 11.94 MMP9 MMP7 MMP2
4
Show member pathways
11.84 MUC5AC MUC4 MUC16
5
Show member pathways
11.75 MMP9 MMP7 MMP2
6
Show member pathways
11.65 MUC5AC MUC4 MUC16
7
Show member pathways
11.54 MMP9 MMP7 MMP2
8 11.45 MMP9 MMP7 MMP2
9 11.25 MMP9 MMP7 MMP2
10 11.13 MMP9 MMP2 ELN
11 11.01 TJP1 SRCIN1 MMP9 MMP2
12 10.94 MMP9 MMP2
13 10.92 MMP9 MMP7 MMP2
14 10.87 MMP9 MMP2
15 10.69 MMP9 MMP7

GO Terms for Senile Ectropion

Cellular components related to Senile Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.02 TJP1 SRCIN1 MUC5AC MUC4 MUC16 MMP2
2 extracellular exosome GO:0070062 9.8 MUC5AC MUC4 MUC16 MMP9 MMP7 FLNA
3 extracellular region GO:0005576 9.56 MUC5AC MUC4 MUC16 MMP9 MMP7 MMP2
4 Golgi lumen GO:0005796 9.33 MUC5AC MUC4 MUC16
5 extracellular matrix GO:0031012 9.02 MUC4 MMP9 MMP7 MMP2 ELN

Biological processes related to Senile Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.58 MUC5AC MUC4 MUC16
2 extracellular matrix organization GO:0030198 9.56 MMP9 MMP7 MMP2 ELN
3 regulation of cell migration GO:0030334 9.5 SRCIN1 LMNA FLNA
4 response to amyloid-beta GO:1904645 9.37 MMP9 MMP2
5 extracellular matrix disassembly GO:0022617 9.33 MMP9 MMP7 MMP2
6 O-glycan processing GO:0016266 9.13 MUC5AC MUC4 MUC16
7 collagen catabolic process GO:0030574 8.8 MMP9 MMP7 MMP2

Molecular functions related to Senile Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metallopeptidase activity GO:0008237 9.33 MMP9 MMP7 MMP2
2 serine-type endopeptidase activity GO:0004252 9.13 MMP9 MMP7 MMP2
3 metalloendopeptidase activity GO:0004222 8.8 MMP9 MMP7 MMP2

Sources for Senile Ectropion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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