MCID: SNL004
MIFTS: 30

Senile Ectropion

Categories: Eye diseases

Aliases & Classifications for Senile Ectropion

MalaCards integrated aliases for Senile Ectropion:

Name: Senile Ectropion 12 15 74
Involutional Ectropion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13356
ICD9CM 36 374.11
SNOMED-CT 69 71659009
UMLS 74 C0155193

Summaries for Senile Ectropion

MalaCards based summary : Senile Ectropion, also known as involutional ectropion, is related to ectropion and elephantiasis. An important gene associated with Senile Ectropion is DNAAF3 (Dynein Axonemal Assembly Factor 3), and among its related pathways/superpathways are Degradation of the extracellular matrix and Proteoglycans in cancer. Affiliated tissues include eye, skin and brain, and related phenotype is cardiovascular system.

Related Diseases for Senile Ectropion

Diseases related to Senile Ectropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 ectropion 10.5
2 elephantiasis 10.2 ELN SRCIN1
3 intestinal volvulus 10.2 SRCIN1 TWIST1
4 entropion 10.2
5 paraphimosis 10.2 KANTR SRCIN1
6 mid-dermal elastolysis 10.2 ELN MMP7
7 optic disk drusen 10.1 ELN KANTR
8 punctate epithelial keratoconjunctivitis 10.1 KANTR SRCIN1
9 cerebral aneurysms 10.1 ELN MMP2
10 hemidystonia 10.1 KANTR TWIST1
11 sorsby fundus dystrophy 10.1 ELN MMP2
12 hypertelorism 10.1 ELN TWIST1
13 astigmatism 10.0
14 enophthalmos 10.0
15 bowen's disease 10.0
16 apical myocardial infarction 10.0 KANTR MMP2
17 aortic aneurysm, familial thoracic 1 10.0 ELN MMP2
18 intracranial aneurysm 10.0 ELN MMP2
19 chronic actinic dermatitis 10.0 ELN MMP9
20 pelvic organ prolapse 9.9 ELN MMP9
21 cerebral arterial disease 9.9 ELN MMP9
22 marfan syndrome 9.9 ELN MMP2
23 brain glioblastoma multiforme 9.9 MMP7 MMP9
24 pediatric multiple sclerosis 9.9 MMP7 MMP9
25 adult astrocytic tumour 9.9 MMP7 MMP9
26 pulmonary emphysema 9.9 ELN MMP9
27 lymphangioleiomyomatosis 9.9 ELN MMP2
28 extracranial arteriovenous malformation 9.9 MMP2 MMP9
29 villous adenocarcinoma 9.9 MMP2 MMP9
30 lentigo maligna melanoma 9.9 MMP2 MMP9
31 psammomatous meningioma 9.9 MMP2 MMP9
32 acute transverse myelitis 9.9 MMP2 MMP9
33 transverse myelitis 9.9 MMP2 MMP9
34 ischemic colitis 9.9 MMP2 MMP9
35 conjunctival nevus 9.9 MMP2 MMP9
36 parotitis 9.8 MMP2 MMP9
37 klatskin's tumor 9.8 MMP2 MMP9
38 corneal ulcer 9.8 MMP2 MMP9
39 nasal cavity squamous cell carcinoma 9.8 MMP2 MMP9
40 odontogenic myxoma 9.8 MMP2 MMP9
41 newcastle disease 9.8 MMP2 MMP9
42 laryngeal disease 9.8 MMP2 MMP9
43 hypertensive heart disease 9.8 MMP2 MMP9
44 adenomyosis 9.8 MMP2 MMP9
45 grade iii astrocytoma 9.8 MMP2 MMP9
46 skin melanoma 9.7 MMP2 MMP9
47 tongue cancer 9.7 MMP2 MMP9
48 oral cancer 9.7 MMP2 MMP9
49 pneumothorax 9.6 ELN MMP2 MMP9
50 aortic aneurysm, familial abdominal, 1 9.6 ELN MMP2 MMP9

Graphical network of the top 20 diseases related to Senile Ectropion:



Diseases related to Senile Ectropion

Symptoms & Phenotypes for Senile Ectropion

MGI Mouse Phenotypes related to Senile Ectropion:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.1 DNAAF3 MMP2 MMP7 MMP9 SRCIN1 TWIST1

Drugs & Therapeutics for Senile Ectropion

Search Clinical Trials , NIH Clinical Center for Senile Ectropion

Genetic Tests for Senile Ectropion

Anatomical Context for Senile Ectropion

MalaCards organs/tissues related to Senile Ectropion:

42
Eye, Skin, Brain, Heart, Tongue

Publications for Senile Ectropion

Articles related to Senile Ectropion:

(show all 28)
# Title Authors Year
1
A quantitative analysis of factors influencing lower lid retraction and involutional ectropion. ( 30467002 )
2019
2
Vector analysis of changes in corneal astigmatism following lateral tarsal strip procedure in patients with involutional ectropion or entropion. ( 30054850 )
2018
3
Lateral tarsal strip versus lateral tarsal strip with three-snip punctoplasty for managing epiphora in involutional ectropion. ( 30217604 )
2018
4
The Use of a Double Suture and Conjunctival Cuts in the Lateral Tarsal Strip: A New Approach to Involutional Ectropion. ( 30320676 )
2018
5
Re: "Lower eyelid involutional ectropion repair with lateral tarsal strip and internal retractor reattachment with full-thickness eyelid sutures". ( 25945875 )
2015
6
Lower eyelid involutional ectropion repair with lateral tarsal strip and internal retractor reattachment with full-thickness eyelid sutures. ( 25025386 )
2014
7
Involutional ectropion and entropion: clinicopathologic correlation between horizontal eyelid laxity and eyelid extracellular matrix. ( 21490515 )
2011
8
Pathogenesis of involutional ectropion and entropion: the involvement of matrix metalloproteinases in elastic fiber degradation. ( 21574802 )
2011
9
The histopathology of involutional ectropion and entropion. ( 20029486 )
2009
10
Corneal topography in involutional ectropion of the lower eyelid: preoperative and postoperative evaluation. ( 15829800 )
2005
11
Role of the lower lid retractors in involutional ectropion repair. ( 12045919 )
2001
12
Causes of involutional ectropion and entropion--age-related tarsal changes are the key. ( 10749160 )
2000
13
The role of enophthalmos in the development of involutional ectropion. ( 12048692 )
1999
14
Senile ectropion. ( 3347680 )
1988
15
Involutional ectropion: a review of the management. ( 3554087 )
1987
16
History of surgery for involutional ectropion. ( 3331928 )
1986
17
Anatomical basis of "senile" ectropion. ( 3940122 )
1985
18
The histopathology of involutional ectropion. ( 4038795 )
1985
19
Double wedge resection for severe involutional ectropion. ( 379728 )
1979
20
Involutional ectropion. ( 729344 )
1978
21
Senile ectropion and entropion: a comparative histopathological study. ( 57735 )
1976
22
Senile ectropion. ( 974868 )
1976
23
Surgery of senile ectropion and entropion. ( 5012696 )
1972
24
Senile ectropion. ( 13959048 )
1962
25
V-Z procedure for the correction of senile ectropion. ( 13840478 )
1959
26
Senile ectropion: analysis of types and surgical correction. ( 13207288 )
1954
27
Senile ectropion and Bowen's disease. ( 21066076 )
1946
28
SUBCUTANEOUS SPLITTING OF THE LID IN THE OPERATIVE TREATMENT OF SENILE ECTROPION*. ( 18170136 )
1945

Variations for Senile Ectropion

Expression for Senile Ectropion

Search GEO for disease gene expression data for Senile Ectropion.

Pathways for Senile Ectropion

Pathways related to Senile Ectropion according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.39 ELN MMP2 MMP7 MMP9
2 12.02 MMP2 MMP9 TWIST1
3
Show member pathways
11.92 ELN MMP2 MMP7 MMP9
4 11.89 MMP2 MMP7 MMP9
5
Show member pathways
11.73 MMP2 MMP7 MMP9
6 11.67 MMP2 MMP9 SRCIN1
7 11.6 MMP2 MMP9 TWIST1
8
Show member pathways
11.49 MMP2 MMP7 MMP9
9 11.47 MMP2 MMP9
10 11.42 MMP2 MMP9
11
Show member pathways
11.4 MMP2 MMP9
12 11.38 MMP2 MMP7 MMP9
13 11.27 MMP2 MMP9
14
Show member pathways
11.24 MMP2 MMP9
15 11.17 ELN MMP9
16 11.15 MMP2 MMP7 MMP9
17 11.1 MMP2 MMP9
18 11.06 MMP2 MMP9
19 10.96 MMP2 MMP9
20 10.93 ELN MMP2 MMP9
21 10.89 MMP2 MMP9
22 10.71 MMP7 MMP9
23 10.58 MMP2 MMP7 MMP9

GO Terms for Senile Ectropion

Cellular components related to Senile Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.13 ELN MMP2 MMP9
2 extracellular matrix GO:0031012 8.92 ELN MMP2 MMP7 MMP9

Biological processes related to Senile Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.54 MMP2 MMP9 TWIST1
2 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.4 MMP2 MMP9
3 embryo implantation GO:0007566 9.32 MMP2 MMP9
4 endodermal cell differentiation GO:0035987 9.26 MMP2 MMP9
5 aortic valve morphogenesis GO:0003180 9.16 ELN TWIST1
6 extracellular matrix disassembly GO:0022617 9.13 MMP2 MMP7 MMP9
7 collagen catabolic process GO:0030574 8.8 MMP2 MMP7 MMP9

Molecular functions related to Senile Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.33 MMP2 MMP7 MMP9
2 metallopeptidase activity GO:0008237 9.13 MMP2 MMP7 MMP9
3 metalloendopeptidase activity GO:0004222 8.8 MMP2 MMP7 MMP9

Sources for Senile Ectropion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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