Aliases & Classifications for Senile Plaque Formation

MalaCards integrated aliases for Senile Plaque Formation:

Name: Senile Plaque Formation 57 55 73

Characteristics:

OMIM:

57
Inheritance:
? autosomal recessive


External Ids:

OMIM 57 269800
MedGen 42 C1849249
SNOMED-CT via HPO 69 88425004 38551001
UMLS 73 C1849249

Summaries for Senile Plaque Formation

MalaCards based summary : Senile Plaque Formation is related to amyloidosis and alzheimer disease. An important gene associated with Senile Plaque Formation is APP (Amyloid Beta Precursor Protein), and among its related pathways/superpathways are Neuroscience and G-protein signaling_Regulation of RAC1 activity. Affiliated tissues include brain, cortex and bone, and related phenotypes are abnormality of the nervous system and senile plaques

Description from OMIM: 269800

Related Diseases for Senile Plaque Formation

Graphical network of the top 20 diseases related to Senile Plaque Formation:



Diseases related to Senile Plaque Formation

Symptoms & Phenotypes for Senile Plaque Formation

Symptoms via clinical synopsis from OMIM:

57
Neuro:
senile plaques


Clinical features from OMIM:

269800

Human phenotypes related to Senile Plaque Formation:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the nervous system 32 HP:0000707
2 senile plaques 32 HP:0100256

MGI Mouse Phenotypes related to Senile Plaque Formation:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.8 APOE APP CHAT

Drugs & Therapeutics for Senile Plaque Formation

Search Clinical Trials , NIH Clinical Center for Senile Plaque Formation

Genetic Tests for Senile Plaque Formation

Anatomical Context for Senile Plaque Formation

MalaCards organs/tissues related to Senile Plaque Formation:

41
Brain, Cortex, Bone

Publications for Senile Plaque Formation

Articles related to Senile Plaque Formation:

(show all 15)
# Title Authors Year
1
Increased densities of resting and activated microglia in the dentate gyrus follow senile plaque formation in the CA1 subfield of the hippocampus in the triple transgenic model of Alzheimer's disease. ( 23827221 )
2013
2
Alterations of synaptic turnover rate in aging may trigger senile plaque formation and neurodegeneration. ( 17405924 )
2007
3
The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice. ( 16298242 )
2006
4
Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. ( 16476660 )
2006
5
Synaptic pathology in the brain cortex of old monkeys as an early alteration in senile plaque formation. ( 16608401 )
2006
6
Exclusive association and simultaneous appearance of congophilic plaques and AT8-positive dystrophic neurites in Tg2576 mice suggest a mechanism of senile plaque formation and progression of neuritic dystrophy in Alzheimer's disease. ( 15372280 )
2004
7
Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model. ( 14745459 )
2003
8
Severe cardiovascular disease and Alzheimer's disease: senile plaque formation in cortical areas. ( 8720786 )
1996
9
Role of microglia in senile plaque formation. ( 8532113 )
1995
10
Cellular dynamics of senile plaque formation and amyloid deposition in cerebral cortex: an ultrastructural study of aged nonhuman primates. ( 8295686 )
1993
11
Reduced transferrin binding in Down syndrome: a route to senile plaque formation and dementia. ( 8280853 )
1993
12
Electron micrograph of diffuse plaques. Initial stage of senile plaque formation in the Alzheimer brain. ( 2679112 )
1989
13
Aluminosilicates and senile plaque formation in Alzheimer's disease. ( 2868298 )
1986
14
Is silica involved in neuritic (senile) plaque formation? ( 6301202 )
1983
15
PRIMARY SYSTEMIC AMYLOIDOSIS; CEREBRAL INVOLVEMENT AND SENILE PLAQUE FORMATION. ( 14105304 )
1964

Variations for Senile Plaque Formation

Expression for Senile Plaque Formation

Search GEO for disease gene expression data for Senile Plaque Formation.

Pathways for Senile Plaque Formation

Pathways related to Senile Plaque Formation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.86 APOE APP
2 10.94 APOE APP
4 10.61 APOE APP
5 10.13 APOE APP

GO Terms for Senile Plaque Formation

Cellular components related to Senile Plaque Formation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 8.62 APOE APP

Biological processes related to Senile Plaque Formation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.43 APOE APP
2 regulation of gene expression GO:0010468 9.4 APOE APP
3 negative regulation of gene expression GO:0010629 9.37 APOE APP
4 cellular protein metabolic process GO:0044267 9.32 APOE APP
5 response to oxidative stress GO:0006979 9.26 APOE APP
6 cholesterol metabolic process GO:0008203 9.16 APOE APP
7 negative regulation of long-term synaptic potentiation GO:1900272 8.96 APOE APP
8 positive regulation of amyloid fibril formation GO:1905908 8.62 APOE APP

Molecular functions related to Senile Plaque Formation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.62 APOE APP

Sources for Senile Plaque Formation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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