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MCID: SNL009
MIFTS: 28

Senile Plaque Formation

Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Senile Plaque Formation

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MalaCards integrated aliases for Senile Plaque Formation:

Name: Senile Plaque Formation 56 54 71

Characteristics:

OMIM:

56
Inheritance:
? autosomal recessive


HPO:

31
senile plaque formation:
Inheritance autosomal recessive inheritance


External Ids:

OMIM 56 269800
MedGen 41 C1849249
SNOMED-CT via HPO 68 258211005 38551001 88425004
UMLS 71 C1849249
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Summaries for Senile Plaque Formation

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MalaCards based summary : Senile Plaque Formation is related to amyloidosis and alzheimer disease. An important gene associated with Senile Plaque Formation is APP (Amyloid Beta Precursor Protein), and among its related pathways/superpathways are Alzheimers Disease and Reelin Pathway (Cajal-Retzius cells). Affiliated tissues include brain, cortex and bone, and related phenotypes are abnormality of the nervous system and senile plaques

More information from OMIM: 269800
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Related Diseases for Senile Plaque Formation

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Diseases related to Senile Plaque Formation via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 amyloidosis 29.8 APP APOE
2 alzheimer disease 29.2 CHAT APP APOE
3 down syndrome 28.9 CHAT APP APOE
4 residual stage of open angle glaucoma 10.0 APP APOE
5 alzheimer's disease 1 9.9 APP APOE
6 al amyloidosis 9.9
7 nervous system disease 9.9 APP APOE
8 binswanger's disease 9.9 APP APOE
9 alzheimer disease 2 9.9 APP APOE
10 arteriolosclerosis 9.9 APP APOE
11 cerebral amyloid angiopathy, app-related 9.9 APP APOE
12 hemorrhage, intracerebral 9.9 APP APOE
13 communicating hydrocephalus 9.9 APP APOE
14 hydrocephalus 9.9 APP APOE
15 ischiocoxopodopatellar syndrome with or without pulmonary arterial hypertension 9.9 APP APOE
16 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 9.9 APP APOE
17 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 9.9 APP APOE
18 aphasia 9.9 APP APOE
19 inclusion body myositis 9.9 APP APOE
20 normal pressure hydrocephalus 9.9 APP APOE
21 tangier disease 9.9 APP APOE
22 cerebral amyloid angiopathy, cst3-related 9.9 APP APOE
23 cerebral degeneration 9.8 APP APOE
24 prion disease 9.8 APP APOE
25 wilson disease 9.8 APP APOE
26 chromosomal disease 9.8 APP APOE
27 speech and communication disorders 9.8 APP APOE
28 disease of mental health 9.8 APP APOE
29 head injury 9.8 CHAT APOE
30 creutzfeldt-jakob disease 9.8 APP APOE
31 cerebrovascular disease 9.7 APP APOE
32 anxiety 9.7 APP APOE
33 leukoencephalopathy, hereditary diffuse, with spheroids 9.7 CHAT APP
34 frontotemporal dementia 9.6 APP APOE
35 motor neuron disease 9.5 CHAT APOE
36 amnestic disorder 9.3 CHAT APP APOE
37 scrapie 9.3 CHAT APP APOE
38 toxic encephalopathy 9.3 CHAT APP APOE
39 supranuclear palsy, progressive, 1 9.3 CHAT APP APOE
40 vascular dementia 9.3 CHAT APP APOE
41 dementia 9.3 CHAT APP APOE
42 dementia, lewy body 9.3 CHAT APP APOE
43 pick disease of brain 9.3 CHAT APP APOE
44 central nervous system disease 9.3 CHAT APP APOE
45 parkinson disease, late-onset 9.2 CHAT APP APOE
46 rett syndrome 9.2 CHAT APOE
47 amyotrophic lateral sclerosis 1 9.2 CHAT APP APOE
48 schizophrenia 9.1 CHAT APP APOE
49 retinitis pigmentosa 8.9 CHAT APP APOE

Graphical network of the top 20 diseases related to Senile Plaque Formation:



Diseases related to Senile Plaque Formation
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Symptoms & Phenotypes for Senile Plaque Formation

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Human phenotypes related to Senile Plaque Formation:

31
# Description HPO Frequency HPO Source Accession
1 abnormality of the nervous system 31 HP:0000707
2 senile plaques 31 HP:0100256

Symptoms via clinical synopsis from OMIM:

56
Neuro:
senile plaques

Clinical features from OMIM:

269800

MGI Mouse Phenotypes related to Senile Plaque Formation:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.8 APOE APP CHAT
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Drugs & Therapeutics for Senile Plaque Formation

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Search Clinical Trials , NIH Clinical Center for Senile Plaque Formation

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Genetic Tests for Senile Plaque Formation

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Anatomical Context for Senile Plaque Formation

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MalaCards organs/tissues related to Senile Plaque Formation:

40
Brain, Cortex, Bone, Bone Marrow, Testes, Amygdala
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Publications for Senile Plaque Formation

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Articles related to Senile Plaque Formation:

(show top 50) (show all 127)
# Title Authors PMID Year
1
[The familial incidence of senile plaques]. 56
5886992 1965
2
Divalent metal transporter 1 is involved in amyloid precursor protein processing and Abeta generation. 54 61
19679638 2009
3
Absence of synaptophysin near cortical neurons containing oligomer Abeta in Alzheimer's disease brain. 61 54
16721760 2006
4
Oxidative stress and Alzheimer disease: the autophagy connection? 54 61
16874106 2006
5
Circulating biomarkers of cognitive decline and dementia. 54 61
16139826 2006
6
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. 61 54
16489755 2006
7
[Expression of apolipoprotein E in Alzheimer's disease and its significance]. 54 61
16468304 2005
8
Presence of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer beta-amyloid deposition. 61 54
7847069 1994
9
Selective alterations of high affinity [3H]forskolin binding sites in Alzheimer's disease: a quantitative autoradiographic study. 61 54
2110494 1990
10
Targeting Infectious Agents as a Therapeutic Strategy in Alzheimer's Disease. 61
32458360 2020
11
Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice. 61
31000769 2019
12
Glial S100A6 Degrades β-amyloid Aggregation through Targeting Competition with Zinc Ions. 61
31440382 2019
13
A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Teprenone in Patients with Alzheimer's Disease. 61
31498121 2019
14
Ovarian Hormone-Dependent Effects of Dietary Lipids on APP/PS1 Mouse Brain. 61
31920626 2019
15
Elimination of amyloid precursor protein in senile plaques in the brain of a patient with Alzheimer-type dementia and Down syndrome. 61
30086988 2019
16
Are N- and C-terminally truncated Aβ species key pathological triggers in Alzheimer's disease? 61
30143530 2018
17
Comparison of β-Amyloid Plaque Labeling Methods: Antibody Staining, Gallyas Silver Staining, and Thioflavin-S Staining. 61
30266107 2018
18
Protective roles of melatonin against the amyloid-dependent development of Alzheimer's disease: A critical review. 61
29981776 2018
19
BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer's disease. 61
29581300 2018
20
Protopanaxadiol derivative DDPU improves behavior and cognitive deficit in AD mice involving regulation of both ER stress and autophagy. 61
29197516 2018
21
Role of Microbes in the Development of Alzheimer's Disease: State of the Art - An International Symposium Presented at the 2017 IAGG Congress in San Francisco. 61
30250480 2018
22
Enriched Environment Significantly Reduced Senile Plaques in a Transgenic Mice Model of Alzheimer's Disease, Improving Memory. 61
30319394 2018
23
Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology. 61
28694093 2017
24
Amyloid β-Induced Redistribution of Transcriptional Factor EB and Lysosomal Dysfunction in Primary Microglial Cells. 61
28769785 2017
25
microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice. 61
27484949 2016
26
Heterocyclic Scaffolds for the Treatment of Alzheimer's Disease. 61
27189601 2016
27
Development of a Novel and Robust Pharmacological Model of Okadaic Acid-induced Alzheimer's Disease in Zebrafish. 61
26295819 2016
28
Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. 61
26549211 2015
29
A novel antagonistic role of natural compound icariin on neurotoxicity of amyloid β peptide. 61
26354216 2015
30
Streptozotocin-induced diabetes increases amyloid plaque deposition in AD transgenic mice through modulating AGEs/RAGE/NF-κB pathway. 61
24228859 2014
31
The proteasome function reporter GFPu accumulates in young brains of the APPswe/PS1dE9 Alzheimer's disease mouse model. 61
24363091 2014
32
Therapeutic effects of the transplantation of VEGF overexpressing bone marrow mesenchymal stem cells in the hippocampus of murine model of Alzheimer's disease. 61
24639647 2014
33
Expression of amyloid-associated miRNAs in both the forebrain cortex and hippocampus of middle-aged rat. 61
24401368 2014
34
[The pathophysiology of Alzheimer's disease with special reference to "amyloid cascade hypothesis"]. 61
24450113 2013
35
The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease. 61
24252754 2013
36
Increased densities of resting and activated microglia in the dentate gyrus follow senile plaque formation in the CA1 subfield of the hippocampus in the triple transgenic model of Alzheimer's disease. 61
23827221 2013
37
Amyloid-β and Alzheimer's disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions. 61
23661001 2013
38
A review on cholinesterase inhibitors for Alzheimer's disease. 61
23435942 2013
39
Formation of spherulitic amyloid β aggregate by anionic liposomes. 61
22842466 2012
40
β-Amyloid peptide is internalized into chick retinal neurons and alters the distribution of myosin Vb. 61
22241730 2012
41
Intracellular amyloid-β accumulation in calcium-binding protein-deficient neurons leads to amyloid-β plaque formation in animal model of Alzheimer's disease. 61
22269161 2012
42
The interplay of cholinergic function, attention, and falls in Parkinson's disease. 61
21898597 2011
43
Pyroglutamate-Aβ 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aβ 11 forming the central core. 61
22001577 2011
44
[Development and topology of senile plaque formation]. 61
22787769 2011
45
Long-term treatment with lithium alleviates memory deficits and reduces amyloid-β production in an aged Alzheimer's disease transgenic mouse model. 61
21321394 2011
46
Study of the interaction between the amyloid beta peptide (1-40) and antioxidant compounds by nuclear magnetic resonance spectroscopy. 61
21053258 2011
47
Effective screen for amyloid β aggregation inhibitor using amyloid β-conjugated gold nanoparticles. 61
21289976 2010
48
Deposition of lactoferrin in fibrillar-type senile plaques in the brains of transgenic mouse models of Alzheimer's disease. 61
20599473 2010
49
[Involvement of beta-amyloid in the etiology of Alzheimer's disease]. 61
20675873 2010
50
Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression. 61
20007471 2009
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Variations for Senile Plaque Formation

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Expression for Senile Plaque Formation

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Search GEO for disease gene expression data for Senile Plaque Formation.
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Pathways for Senile Plaque Formation

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Pathways related to Senile Plaque Formation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Alzheimers Disease 1
11.43 APP APOE
2
Reelin Pathway (Cajal-Retzius cells) 63
11.33 APP APOE
4
Alzheimers Disease Pathway 63
10.61 APP APOE
5
A-beta Uptake and Degradation 64
10.13 APP APOE
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GO Terms for Senile Plaque Formation

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Cellular components related to Senile Plaque Formation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 8.96 APP APOE
2 early endosome GO:0005769 8.62 APP APOE

Biological processes related to Senile Plaque Formation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.43 APP APOE
2 cellular protein metabolic process GO:0044267 9.4 APP APOE
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.37 APP APOE
4 neuron projection development GO:0031175 9.32 APP APOE
5 response to oxidative stress GO:0006979 9.26 APP APOE
6 cholesterol metabolic process GO:0008203 9.16 APP APOE
7 negative regulation of long-term synaptic potentiation GO:1900272 8.96 APP APOE
8 positive regulation of amyloid fibril formation GO:1905908 8.62 APP APOE

Molecular functions related to Senile Plaque Formation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.62 APP APOE
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Sources for Senile Plaque Formation

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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