Aliases & Classifications for Senile Plaque Formation

MalaCards integrated aliases for Senile Plaque Formation:

Name: Senile Plaque Formation 57 54 70

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
? autosomal recessive


HPO:

31
senile plaque formation:
Inheritance autosomal recessive inheritance


External Ids:

OMIM® 57 269800
MedGen 41 C1849249
SNOMED-CT via HPO 68 258211005 38551001 88425004
UMLS 70 C1849249

Summaries for Senile Plaque Formation

MalaCards based summary : Senile Plaque Formation is related to amyloidosis and alzheimer disease. An important gene associated with Senile Plaque Formation is APP (Amyloid Beta Precursor Protein), and among its related pathways/superpathways are Alzheimers Disease and Reelin Pathway (Cajal-Retzius cells). Affiliated tissues include brain, cortex and bone marrow, and related phenotypes are abnormality of the nervous system and senile plaques

More information from OMIM: 269800

Related Diseases for Senile Plaque Formation

Diseases related to Senile Plaque Formation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 amyloidosis 29.9 APP APOE
2 alzheimer disease 29.5 CHAT APP APOE
3 down syndrome 29.3 CHAT APP APOE
4 al amyloidosis 10.0
5 residual stage of open angle glaucoma 10.0 APP APOE
6 alzheimer's disease 1 10.0 APP APOE
7 binswanger's disease 10.0 APP APOE
8 arteriolosclerosis 10.0 APP APOE
9 alzheimer disease 2 10.0 APP APOE
10 cerebral amyloid angiopathy, app-related 10.0 APP APOE
11 communicating hydrocephalus 10.0 APP APOE
12 hydrocephalus 10.0 APP APOE
13 early-onset, autosomal dominant alzheimer disease 10.0 APP APOE
14 hemorrhage, intracerebral 9.9 APP APOE
15 alzheimer disease 3 9.9 APP APOE
16 ischiocoxopodopatellar syndrome with or without pulmonary arterial hypertension 9.9 APP APOE
17 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 9.9 APP APOE
18 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 9.9 APP APOE
19 c syndrome 9.9 APP APOE
20 aphasia 9.9 APP APOE
21 normal pressure hydrocephalus 9.9 APP APOE
22 inclusion body myositis 9.9 APP APOE
23 tangier disease 9.9 APP APOE
24 cerebral amyloid angiopathy, cst3-related 9.9 APP APOE
25 chromosomal duplication syndrome 9.9 APP APOE
26 wilson disease 9.9 APP APOE
27 cerebral degeneration 9.9 APP APOE
28 chromosomal disease 9.9 APP APOE
29 head injury 9.9 CHAT APOE
30 speech and communication disorders 9.9 APP APOE
31 movement disease 9.9 APP APOE
32 creutzfeldt-jakob disease 9.8 APP APOE
33 cerebrovascular disease 9.8 APP APOE
34 leukoencephalopathy, hereditary diffuse, with spheroids 9.8 CHAT APP
35 anxiety 9.7 APP APOE
36 frontotemporal dementia 9.7 APP APOE
37 mild cognitive impairment 9.5 CHAT APP APOE
38 amnestic disorder 9.5 CHAT APP APOE
39 scrapie 9.5 CHAT APP APOE
40 toxic encephalopathy 9.5 CHAT APP APOE
41 supranuclear palsy, progressive, 1 9.5 CHAT APP APOE
42 vascular dementia 9.5 CHAT APP APOE
43 dementia 9.5 CHAT APP APOE
44 dementia, lewy body 9.5 CHAT APP APOE
45 pick disease of brain 9.5 CHAT APP APOE
46 central nervous system disease 9.5 CHAT APP APOE
47 motor neuron disease 9.5 CHAT APP APOE
48 rett syndrome 9.5 CHAT APOE
49 parkinson disease, late-onset 9.4 CHAT APP APOE
50 amyotrophic lateral sclerosis 1 9.4 CHAT APP APOE

Graphical network of the top 20 diseases related to Senile Plaque Formation:



Diseases related to Senile Plaque Formation

Symptoms & Phenotypes for Senile Plaque Formation

Human phenotypes related to Senile Plaque Formation:

31
# Description HPO Frequency HPO Source Accession
1 abnormality of the nervous system 31 HP:0000707
2 senile plaques 31 HP:0100256

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Neuro:
senile plaques

Clinical features from OMIM®:

269800 (Updated 20-May-2021)

MGI Mouse Phenotypes related to Senile Plaque Formation:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.13 APOE APP CHAT
2 muscle MP:0005369 8.8 APOE APP CHAT

Drugs & Therapeutics for Senile Plaque Formation

Search Clinical Trials , NIH Clinical Center for Senile Plaque Formation

Genetic Tests for Senile Plaque Formation

Anatomical Context for Senile Plaque Formation

MalaCards organs/tissues related to Senile Plaque Formation:

40
Brain, Cortex, Bone Marrow, Amygdala

Publications for Senile Plaque Formation

Articles related to Senile Plaque Formation:

(show top 50) (show all 131)
# Title Authors PMID Year
1
[The familial incidence of senile plaques]. 57
5886992 1965
2
Divalent metal transporter 1 is involved in amyloid precursor protein processing and Abeta generation. 54 61
19679638 2009
3
Absence of synaptophysin near cortical neurons containing oligomer Abeta in Alzheimer's disease brain. 54 61
16721760 2006
4
Oxidative stress and Alzheimer disease: the autophagy connection? 54 61
16874106 2006
5
Circulating biomarkers of cognitive decline and dementia. 54 61
16139826 2006
6
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. 54 61
16489755 2006
7
[Expression of apolipoprotein E in Alzheimer's disease and its significance]. 61 54
16468304 2005
8
Presence of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer beta-amyloid deposition. 54 61
7847069 1994
9
Selective alterations of high affinity [3H]forskolin binding sites in Alzheimer's disease: a quantitative autoradiographic study. 61 54
2110494 1990
10
Discovery of Natural Inhibitors of Cholinesterases from Hydrangea: In Vitro and In Silico Approaches. 61
33477276 2021
11
Microbial involvement in Alzheimer disease development and progression. 61
32709243 2020
12
Targeting Infectious Agents as a Therapeutic Strategy in Alzheimer's Disease. 61
32458360 2020
13
Amyloid-β Peptide Impact on Synaptic Function and Neuroepigenetic Gene Control Reveal New Therapeutic Strategies for Alzheimer's Disease. 61
33304239 2020
14
Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice. 61
31000769 2019
15
Glial S100A6 Degrades β-amyloid Aggregation through Targeting Competition with Zinc Ions. 61
31440382 2019
16
Protection against Neurodegeneration in the Hippocampus Using Sialic Acid- and 5-HT-Moduline-Conjugated Lipopolymer Nanoparticles. 61
33405649 2019
17
Ovarian Hormone-Dependent Effects of Dietary Lipids on APP/PS1 Mouse Brain. 61
31920626 2019
18
Elimination of amyloid precursor protein in senile plaques in the brain of a patient with Alzheimer-type dementia and Down syndrome. 61
30086988 2019
19
A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Teprenone in Patients with Alzheimer's Disease. 61
31498121 2019
20
Are N- and C-terminally truncated Aβ species key pathological triggers in Alzheimer's disease? 61
30143530 2018
21
Comparison of β-Amyloid Plaque Labeling Methods: Antibody Staining, Gallyas Silver Staining, and Thioflavin-S Staining. 61
30266107 2018
22
Protective roles of melatonin against the amyloid-dependent development of Alzheimer's disease: A critical review. 61
29981776 2018
23
BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer's disease. 61
29581300 2018
24
Protopanaxadiol derivative DDPU improves behavior and cognitive deficit in AD mice involving regulation of both ER stress and autophagy. 61
29197516 2018
25
Enriched Environment Significantly Reduced Senile Plaques in a Transgenic Mice Model of Alzheimer's Disease, Improving Memory. 61
30319394 2018
26
Role of Microbes in the Development of Alzheimer's Disease: State of the Art - An International Symposium Presented at the 2017 IAGG Congress in San Francisco. 61
30250480 2018
27
Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology. 61
28694093 2017
28
Amyloid β-Induced Redistribution of Transcriptional Factor EB and Lysosomal Dysfunction in Primary Microglial Cells. 61
28769785 2017
29
microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice. 61
27484949 2016
30
Heterocyclic Scaffolds for the Treatment of Alzheimer's Disease. 61
27189601 2016
31
Development of a Novel and Robust Pharmacological Model of Okadaic Acid-induced Alzheimer's Disease in Zebrafish. 61
26295819 2016
32
Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. 61
26549211 2015
33
A novel antagonistic role of natural compound icariin on neurotoxicity of amyloid β peptide. 61
26354216 2015
34
Streptozotocin-induced diabetes increases amyloid plaque deposition in AD transgenic mice through modulating AGEs/RAGE/NF-κB pathway. 61
24228859 2014
35
The proteasome function reporter GFPu accumulates in young brains of the APPswe/PS1dE9 Alzheimer's disease mouse model. 61
24363091 2014
36
Therapeutic effects of the transplantation of VEGF overexpressing bone marrow mesenchymal stem cells in the hippocampus of murine model of Alzheimer's disease. 61
24639647 2014
37
Expression of amyloid-associated miRNAs in both the forebrain cortex and hippocampus of middle-aged rat. 61
24401368 2014
38
[The pathophysiology of Alzheimer's disease with special reference to "amyloid cascade hypothesis"]. 61
24450113 2013
39
The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease. 61
24252754 2013
40
Increased densities of resting and activated microglia in the dentate gyrus follow senile plaque formation in the CA1 subfield of the hippocampus in the triple transgenic model of Alzheimer's disease. 61
23827221 2013
41
Amyloid-β and Alzheimer's disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions. 61
23661001 2013
42
A review on cholinesterase inhibitors for Alzheimer's disease. 61
23435942 2013
43
Formation of spherulitic amyloid β aggregate by anionic liposomes. 61
22842466 2012
44
β-Amyloid peptide is internalized into chick retinal neurons and alters the distribution of myosin Vb. 61
22241730 2012
45
Intracellular amyloid-β accumulation in calcium-binding protein-deficient neurons leads to amyloid-β plaque formation in animal model of Alzheimer's disease. 61
22269161 2012
46
The interplay of cholinergic function, attention, and falls in Parkinson's disease. 61
21898597 2011
47
Pyroglutamate-Aβ 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aβ 11 forming the central core. 61
22001577 2011
48
[Development and topology of senile plaque formation]. 61
22787769 2011
49
Study of the interaction between the amyloid beta peptide (1-40) and antioxidant compounds by nuclear magnetic resonance spectroscopy. 61
21053258 2011
50
Long-term treatment with lithium alleviates memory deficits and reduces amyloid-β production in an aged Alzheimer's disease transgenic mouse model. 61
21321394 2011

Variations for Senile Plaque Formation

Expression for Senile Plaque Formation

Search GEO for disease gene expression data for Senile Plaque Formation.

Pathways for Senile Plaque Formation

Pathways related to Senile Plaque Formation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.43 APP APOE
2 11.33 APP APOE
4 10.61 APP APOE
5 10.13 APP APOE

GO Terms for Senile Plaque Formation

Cellular components related to Senile Plaque Formation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 8.96 APP APOE
2 early endosome GO:0005769 8.62 APP APOE

Biological processes related to Senile Plaque Formation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.4 APP APOE
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.37 APP APOE
3 neuron projection development GO:0031175 9.32 APP APOE
4 response to oxidative stress GO:0006979 9.26 APP APOE
5 cholesterol metabolic process GO:0008203 9.16 APP APOE
6 negative regulation of long-term synaptic potentiation GO:1900272 8.96 APP APOE
7 positive regulation of amyloid fibril formation GO:1905908 8.62 APP APOE

Molecular functions related to Senile Plaque Formation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.62 APP APOE

Sources for Senile Plaque Formation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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