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MCID: SNL009
MIFTS: 28

Senile Plaque Formation

Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Senile Plaque Formation

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MalaCards integrated aliases for Senile Plaque Formation:

Name: Senile Plaque Formation 57 55 72

Characteristics:

OMIM:

57
Inheritance:
? autosomal recessive


HPO:

32
senile plaque formation:
Inheritance autosomal recessive inheritance


External Ids:

OMIM 57 269800
MedGen 42 C1849249
UMLS 72 C1849249
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Summaries for Senile Plaque Formation

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MalaCards based summary : Senile Plaque Formation is related to amyloidosis and alzheimer disease. An important gene associated with Senile Plaque Formation is APP (Amyloid Beta Precursor Protein), and among its related pathways/superpathways are Neuroscience and Reelin Pathway (Cajal-Retzius cells). Affiliated tissues include brain, cortex and bone, and related phenotypes are abnormality of the nervous system and senile plaques

More information from OMIM: 269800
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Related Diseases for Senile Plaque Formation

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Diseases related to Senile Plaque Formation via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
# Related Disease Score Top Affiliating Genes
1 amyloidosis 29.7 APP APOE
2 alzheimer disease 29.0 CHAT APP APOE
3 dementia 28.7 CHAT APP APOE
4 alzheimer's disease 1 10.0 APP APOE
5 gait apraxia 10.0 APP APOE
6 kohlschutter-tonz syndrome 9.9 APP APOE
7 alzheimer disease mitochondrial 9.9 APP APOE
8 down syndrome 9.9
9 al amyloidosis 9.9
10 binswanger's disease 9.9 APP APOE
11 alzheimer disease 2 9.9 APP APOE
12 hemorrhage, intracerebral 9.9 APP APOE
13 aphasia 9.9 APP APOE
14 cerebral amyloid angiopathy, cst3-related 9.8 APP APOE
15 inclusion body myositis 9.8 APP APOE
16 dementia, lewy body 9.8 APP APOE
17 head injury 9.8 CHAT APOE
18 disease of mental health 9.8 APP APOE
19 cerebrovascular disease 9.7 APP APOE
20 frontotemporal dementia 9.6 APP APOE
21 hydrocephalus 9.4 APP APOE
22 supranuclear palsy, progressive, 1 9.2 CHAT APP APOE
23 pick disease of brain 9.2 CHAT APP APOE
24 vascular dementia 9.2 CHAT APP APOE
25 nervous system disease 9.2 CHAT APP APOE
26 central nervous system disease 9.2 CHAT APP APOE
27 parkinson disease, late-onset 9.1 CHAT APP APOE

Graphical network of the top 20 diseases related to Senile Plaque Formation:



Diseases related to Senile Plaque Formation
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Symptoms & Phenotypes for Senile Plaque Formation

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Human phenotypes related to Senile Plaque Formation:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the nervous system 32 HP:0000707
2 senile plaques 32 HP:0100256

Symptoms via clinical synopsis from OMIM:

57
Neuro:
senile plaques

Clinical features from OMIM:

269800

MGI Mouse Phenotypes related to Senile Plaque Formation:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.8 APOE APP CHAT
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Drugs & Therapeutics for Senile Plaque Formation

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Search Clinical Trials , NIH Clinical Center for Senile Plaque Formation

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Genetic Tests for Senile Plaque Formation

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Anatomical Context for Senile Plaque Formation

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MalaCards organs/tissues related to Senile Plaque Formation:

41
Brain, Cortex, Bone, Testes, Bone Marrow, Amygdala
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Publications for Senile Plaque Formation

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Articles related to Senile Plaque Formation:

(show top 50) (show all 123)
# Title Authors PMID Year
1
[The familial incidence of senile plaques]. 8
5886992 1965
2
Divalent metal transporter 1 is involved in amyloid precursor protein processing and Abeta generation. 9 38
19679638 2009
3
Absence of synaptophysin near cortical neurons containing oligomer Abeta in Alzheimer's disease brain. 9 38
16721760 2006
4
Oxidative stress and Alzheimer disease: the autophagy connection? 9 38
16874106 2006
5
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. 9 38
16489755 2006
6
Circulating biomarkers of cognitive decline and dementia. 9 38
16139826 2006
7
[Expression of apolipoprotein E in Alzheimer's disease and its significance]. 9 38
16468304 2005
8
Presence of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer beta-amyloid deposition. 9 38
7847069 1994
9
Selective alterations of high affinity [3H]forskolin binding sites in Alzheimer's disease: a quantitative autoradiographic study. 9 38
2110494 1990
10
Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice. 38
31000769 2019
11
Elimination of amyloid precursor protein in senile plaques in the brain of a patient with Alzheimer-type dementia and Down syndrome. 38
30086988 2019
12
Are N- and C-terminally truncated Aβ species key pathological triggers in Alzheimer's disease? 38
30143530 2018
13
Comparison of β-Amyloid Plaque Labeling Methods: Antibody Staining, Gallyas Silver Staining, and Thioflavin-S Staining. 38
30266107 2018
14
Protective roles of melatonin against the amyloid-dependent development of Alzheimer's disease: A critical review. 38
29981776 2018
15
BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer's disease. 38
29581300 2018
16
Protopanaxadiol derivative DDPU improves behavior and cognitive deficit in AD mice involving regulation of both ER stress and autophagy. 38
29197516 2018
17
Role of Microbes in the Development of Alzheimer's Disease: State of the Art - An International Symposium Presented at the 2017 IAGG Congress in San Francisco. 38
30250480 2018
18
Enriched Environment Significantly Reduced Senile Plaques in a Transgenic Mice Model of Alzheimer's Disease, Improving Memory. 38
30319394 2018
19
Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology. 38
28694093 2017
20
Amyloid β-Induced Redistribution of Transcriptional Factor EB and Lysosomal Dysfunction in Primary Microglial Cells. 38
28769785 2017
21
microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice. 38
27484949 2016
22
Development of a Novel and Robust Pharmacological Model of Okadaic Acid-induced Alzheimer's Disease in Zebrafish. 38
26295819 2016
23
Heterocyclic Scaffolds for the Treatment of Alzheimer's Disease. 38
27189601 2016
24
Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. 38
26549211 2015
25
A novel antagonistic role of natural compound icariin on neurotoxicity of amyloid β peptide. 38
26354216 2015
26
Streptozotocin-induced diabetes increases amyloid plaque deposition in AD transgenic mice through modulating AGEs/RAGE/NF-κB pathway. 38
24228859 2014
27
The proteasome function reporter GFPu accumulates in young brains of the APPswe/PS1dE9 Alzheimer's disease mouse model. 38
24363091 2014
28
Expression of amyloid-associated miRNAs in both the forebrain cortex and hippocampus of middle-aged rat. 38
24401368 2014
29
Therapeutic effects of the transplantation of VEGF overexpressing bone marrow mesenchymal stem cells in the hippocampus of murine model of Alzheimer's disease. 38
24639647 2014
30
[The pathophysiology of Alzheimer's disease with special reference to "amyloid cascade hypothesis"]. 38
24450113 2013
31
The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease. 38
24252754 2013
32
Increased densities of resting and activated microglia in the dentate gyrus follow senile plaque formation in the CA1 subfield of the hippocampus in the triple transgenic model of Alzheimer's disease. 38
23827221 2013
33
Amyloid-β and Alzheimer's disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions. 38
23661001 2013
34
A review on cholinesterase inhibitors for Alzheimer's disease. 38
23435942 2013
35
Formation of spherulitic amyloid β aggregate by anionic liposomes. 38
22842466 2012
36
β-Amyloid peptide is internalized into chick retinal neurons and alters the distribution of myosin Vb. 38
22241730 2012
37
Intracellular amyloid-β accumulation in calcium-binding protein-deficient neurons leads to amyloid-β plaque formation in animal model of Alzheimer's disease. 38
22269161 2012
38
The interplay of cholinergic function, attention, and falls in Parkinson's disease. 38
21898597 2011
39
Pyroglutamate-Aβ 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aβ 11 forming the central core. 38
22001577 2011
40
[Development and topology of senile plaque formation]. 38
22787769 2011
41
Study of the interaction between the amyloid beta peptide (1-40) and antioxidant compounds by nuclear magnetic resonance spectroscopy. 38
21053258 2011
42
Long-term treatment with lithium alleviates memory deficits and reduces amyloid-β production in an aged Alzheimer's disease transgenic mouse model. 38
21321394 2011
43
Effective screen for amyloid β aggregation inhibitor using amyloid β-conjugated gold nanoparticles. 38
21289976 2010
44
Deposition of lactoferrin in fibrillar-type senile plaques in the brains of transgenic mouse models of Alzheimer's disease. 38
20599473 2010
45
[Involvement of beta-amyloid in the etiology of Alzheimer's disease]. 38
20675873 2010
46
Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression. 38
20007471 2009
47
Effects of memantine on soluble Alphabeta(25-35)-induced changes in peptidergic and glial cells in Alzheimer's disease model rat brain regions. 38
19733635 2009
48
Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice. 38
19683527 2009
49
Amyloid-beta peptide Abetap3-42 affects early aggregation of full-length Abeta1-42. 38
19428760 2009
50
[A case of Creutzfeldt-Jakob disease with codon 129 polymorphism and codon 180 point mutation]. 38
18332581 2008
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Variations for Senile Plaque Formation

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Expression for Senile Plaque Formation

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Search GEO for disease gene expression data for Senile Plaque Formation.
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Pathways for Senile Plaque Formation

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Pathways related to Senile Plaque Formation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
11.9 APP APOE
2
Reelin Pathway (Cajal-Retzius cells) 64
11.33 APP APOE
3
G-protein signaling_Regulation of RAC1 activity 22
10.94 APP APOE
5
Alzheimers Disease Pathway 64
10.61 APP APOE
6
A-beta Pathways: Uptake and Degradation 65
10.13 APP APOE
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GO Terms for Senile Plaque Formation

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Cellular components related to Senile Plaque Formation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 8.96 APP APOE
2 early endosome GO:0005769 8.62 APP APOE

Biological processes related to Senile Plaque Formation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.43 APP APOE
2 negative regulation of gene expression GO:0010629 9.4 APP APOE
3 regulation of gene expression GO:0010468 9.37 APP APOE
4 cellular protein metabolic process GO:0044267 9.32 APP APOE
5 response to oxidative stress GO:0006979 9.26 APP APOE
6 cholesterol metabolic process GO:0008203 9.16 APP APOE
7 negative regulation of long-term synaptic potentiation GO:1900272 8.96 APP APOE
8 positive regulation of amyloid fibril formation GO:1905908 8.62 APP APOE

Molecular functions related to Senile Plaque Formation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.62 APP APOE
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Sources for Senile Plaque Formation

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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