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MCID: SNS003
MIFTS: 54

Sensory Peripheral Neuropathy

Categories: Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Sensory Peripheral Neuropathy

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MalaCards integrated aliases for Sensory Peripheral Neuropathy:

Name: Sensory Peripheral Neuropathy 12 15
Sensory Neuropathy 12 74 29 54 6 15 71
Hereditary Sensory and Autonomic Neuropathies 71
Peripheral Sensory Neuropathy 12

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2491
ICD9CM 34 356.2
MeSH 43 D009477
NCIt 49 C3501
SNOMED-CT 67 11442006 95662005
UMLS 71 C0027889 C0151313 C0699739
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Summaries for Sensory Peripheral Neuropathy

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Disease Ontology : 12 A neuropathy that involves damage to nerves of the peripheral nervous system.

MalaCards based summary : Sensory Peripheral Neuropathy, also known as sensory neuropathy, is related to hereditary motor and sensory neuropathy, type iic and charcot-marie-tooth disease, axonal, type 2a1, and has symptoms including hyperesthesia, dysesthesia and sciatica. An important gene associated with Sensory Peripheral Neuropathy is MPZ (Myelin Protein Zero), and among its related pathways/superpathways are Guidance Cues and Growth Cone Motility and Neural Crest Differentiation. The drugs Methylcobalamin and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 74 Peripheral neuropathy, often shortened to neuropathy, is a general term describing disease affecting the... more...

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Related Diseases for Sensory Peripheral Neuropathy

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Diseases related to Sensory Peripheral Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 632)
# Related Disease Score Top Affiliating Genes
1 hereditary motor and sensory neuropathy, type iic 34.8 MPZ MFN2 GJB1 GDAP1
2 charcot-marie-tooth disease, axonal, type 2a1 34.3 MPZ MFN2 GDAP1
3 neuropathy, hereditary motor and sensory, russe type 34.3 NDRG1 GDAP1 EGR2
4 neuropathy, hereditary sensory and autonomic, type iia 34.0 SPTLC1 SLC12A6 NGF LITAF GDAP1 FLVCR1
5 charcot-marie-tooth disease, demyelinating, type 1b 34.0 PRX PMP22 MTMR2 MPZ MFN2 LITAF
6 neuropathy, hereditary sensory and autonomic, type ic 33.8 SPTLC1 LITAF
7 charcot-marie-tooth disease/hereditary motor and sensory neuropathy 33.7 SPTLC1 SLC12A6 PRX PMP22 NDRG1 MPZ
8 roussy-levy hereditary areflexic dystasia 33.7 PMP22 MPZ
9 neuropathy, hereditary sensory and autonomic, type v 33.7 SPTLC1 NGF
10 charcot-marie-tooth disease, demyelinating, type 1a 33.7 PRX PMP22 NTF3 MTMR2 MPZ MFN2
11 charcot-marie-tooth disease, type 4d 33.6 NDRG1 MTMR2 MPZ LITAF GJB1 GDAP1
12 charcot-marie-tooth disease, demyelinating, type 1c 33.6 PRX PMP22 MTMR2 MPZ LITAF GJB1
13 charcot-marie-tooth disease, demyelinating, type 1d 33.5 PRX PMP22 MTMR2 MPZ LITAF GJB1
14 charcot-marie-tooth disease, axonal, type 2b 33.5 SPTLC1 MTMR2 MPZ LITAF GJB1 GDAP1
15 charcot-marie-tooth disease, axonal, type 2b2 33.4 MPZ MFN2 GDAP1
16 charcot-marie-tooth disease, type 4b1 33.2 PRX MTMR2 MPZ LITAF GDAP1 FGD4
17 charcot-marie-tooth disease x-linked recessive 4 33.2 MPZ GJB1
18 neuropathy, hereditary, with liability to pressure palsies 33.2 PRX PMP22 NDRG1 MTMR2 MPZ MFN2
19 motor peripheral neuropathy 33.2 SLC12A6 PMP22 MFN2 MAG LITAF GJB1
20 charcot-marie-tooth disease, type 4b2 33.1 PRX MTMR2 MPZ LITAF GJB1 GDAP1
21 charcot-marie-tooth disease 33.1 SPTLC1 SLC12A6 PRX PMP22 NTF3 NGF
22 charcot-marie-tooth disease, axonal, type 2d 33.1 MPZ MFN2 GJB1 GDAP1
23 charcot-marie-tooth disease and deafness 33.1 SPTLC1 PRX PMP22 NDRG1 MTMR2 MPZ
24 charcot-marie-tooth disease, axonal, type 2b1 33.0 MFN2 GDAP1
25 hereditary neuropathies 33.0 PRX PMP22 NDRG1 MTMR2 MPZ MFN2
26 charcot-marie-tooth disease, type 4a 33.0 PRX MTMR2 MPZ MFN2 LITAF GJB1
27 charcot-marie-tooth disease intermediate type 33.0 MTMR2 MPZ MFN2 LITAF GJB1 GDAP1
28 charcot-marie-tooth disease, x-linked recessive, 2 33.0 MPZ MFN2 LITAF GJB1 EGR2
29 neuropathy, congenital hypomyelinating, 1, autosomal recessive 32.6 SLC12A6 PRX PMP22 NTF3 NDRG1 MTMR2
30 charcot-marie-tooth disease, axonal, type 2e 32.6 SPTLC1 SLC12A6 PRX PMP22 NTF3 NGF
31 charcot-marie-tooth disease, x-linked dominant, 1 32.1 SPTLC1 PRX PMP22 MTMR2 MPZ MFN2
32 charcot-marie-tooth disease, axonal, type 2p 32.1 SLC12A6 LITAF GDAP1
33 charcot-marie-tooth disease, axonal, type 2f 32.0 MPZ MFN2 LITAF GJB1 GDAP1
34 charcot-marie-tooth disease, recessive intermediate a 31.9 MFN2 GDAP1
35 hypertrophic neuropathy of dejerine-sottas 31.9 PRX PMP22 NDRG1 MTMR2 MPZ MFN2
36 charcot-marie-tooth disease, type 4c 31.9 NDRG1 MTMR2 MPZ LITAF GJB1 GDAP1
37 charcot-marie-tooth disease, dominant intermediate e 31.6 MTMR2 MPZ GDAP1
38 charcot-marie-tooth disease, axonal, type 2l 31.6 MPZ MFN2 GDAP1
39 charcot-marie-tooth disease, type 4b3 31.6 PMP22 MTMR2 MPZ GDAP1
40 charcot-marie-tooth disease, dominant intermediate c 31.6 SPTLC1 MPZ GJB1 GDAP1
41 charcot-marie-tooth disease, dominant intermediate a 31.6 PRX MPZ GJB1 GDAP1
42 charcot-marie-tooth disease, axonal, type 2i 31.6 PRX MPZ GJB1 GDAP1
43 axonal neuropathy 31.5 PMP22 MFN2 GDAP1
44 charcot-marie-tooth disease, axonal, type 2r 31.5 SLC12A6 GDAP1
45 charcot-marie-tooth disease, demyelinating, type 1f 31.5 MTMR2 MPZ LITAF GJB1 GDAP1
46 charcot-marie-tooth disease, dominant intermediate b 31.5 MTMR2 MPZ LITAF GJB1 GDAP1
47 charcot-marie-tooth disease, axonal, type 2j 31.4 PRX MTMR2 MPZ GDAP1 EGR2
48 charcot-marie-tooth disease, type 4j 31.4 PRX MTMR2 MPZ LITAF GDAP1 FGD4
49 charcot-marie-tooth disease, type 4h 31.4 PRX NDRG1 MTMR2 MPZ GDAP1 FGD4
50 guillain-barre syndrome 31.3 PMP22 MPZ MAG

Graphical network of the top 20 diseases related to Sensory Peripheral Neuropathy:



Diseases related to Sensory Peripheral Neuropathy
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Symptoms & Phenotypes for Sensory Peripheral Neuropathy

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UMLS symptoms related to Sensory Peripheral Neuropathy:


hyperesthesia, dysesthesia, sciatica, neurologic symptoms

GenomeRNAi Phenotypes related to Sensory Peripheral Neuropathy according to GeneCards Suite gene sharing:

26 (show all 31)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-103 10.18 FGD4
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 10.18 SLC12A6
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-108 10.18 NTF3
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-121 10.18 FGD4 SLC12A6
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-125 10.18 FGD4
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 10.18 FGD4
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-143 10.18 GJB1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-149 10.18 FGD4
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 10.18 FGD4
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-163 10.18 GJB1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 10.18 SLC12A6
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-185 10.18 GJB1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-202 10.18 NTF3
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 10.18 SLC12A6
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 10.18 NTF3
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 10.18 SLC12A6
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 10.18 SLC12A6
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-43 10.18 SLC12A6
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-49 10.18 GJB1
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 10.18 SLC12A6
21 Decreased viability GR00055-A-1 10.07 GJB1
22 Decreased viability GR00055-A-2 10.07 GJB1
23 Decreased viability GR00221-A-1 10.07 ELAVL4
24 Decreased viability GR00221-A-2 10.07 ELAVL4
25 Decreased viability GR00249-S 10.07 GJB1 MPZ NDRG1 NTF3
26 Decreased viability GR00381-A-1 10.07 FGD4 MPZ PRX
27 Decreased viability GR00381-A-3 10.07 MPZ
28 Decreased viability GR00386-A-1 10.07 CCT4 EGR2 ELAVL3 MPZ NGF NTF3
29 Decreased viability GR00402-S-2 10.07 CCT4 FGD4 GJB1 MPZ MTMR2 NDRG1
30 Increased gamma-H2AX phosphorylation GR00053-A 9.28 CCT4 EGR2 ELAVL4 GJB1 MAG MPZ
31 Decreased replication of vaccinia virus (VACV) GR00362-A 8.96 EGR2

MGI Mouse Phenotypes related to Sensory Peripheral Neuropathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.3 EGR2 ELAVL3 ELAVL4 FGD4 GDAP1 GJB1
2 growth/size/body region MP:0005378 10.13 EGR2 FGD4 FLVCR1 GJB1 MFN2 MPZ
3 homeostasis/metabolism MP:0005376 10.13 EGR2 ELAVL3 ELAVL4 FLVCR1 GDAP1 GJB1
4 mortality/aging MP:0010768 9.97 EGR2 ELAVL3 ELAVL4 FLVCR1 GJB1 MFN2
5 nervous system MP:0003631 9.91 EGR2 ELAVL3 ELAVL4 FGD4 GDAP1 GJB1
6 reproductive system MP:0005389 9.32 EGR2 ELAVL4 FLVCR1 GDAP1 MPZ MTMR2
Sources

Drugs & Therapeutics for Sensory Peripheral Neuropathy

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Drugs for Sensory Peripheral Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 177)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
2
Hydroxocobalamin Approved Phase 4 13422-51-0 15589840 11953898
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Nortriptyline Approved Phase 4 72-69-5 4543
5
Mexiletine Approved, Investigational Phase 4 31828-71-4 4178
6
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
7
Zinc Approved, Investigational Phase 4 7440-66-6 32051
8
Insulin glargine Approved Phase 4 160337-95-1
9
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
10
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
11
Pyridoxal Phosphate Approved, Investigational, Nutraceutical Phase 4 54-47-7 1051
12
Cobalamin Experimental Phase 4 13408-78-1 6857388
13 Vitamin B 6 Phase 4
14 Vitamin B 12 Phase 4
15 Vitamin B12 Phase 4
16 Sodium Channel Blockers Phase 4
17 Anesthetics Phase 4
18 Anti-Arrhythmia Agents Phase 4
19 Diuretics, Potassium Sparing Phase 4
20 Anesthetics, Local Phase 4
21 Adrenergic Agents Phase 4
22 Antidepressive Agents, Tricyclic Phase 4
23 Excitatory Amino Acid Antagonists Phase 4
24 Hypoglycemic Agents Phase 4
25 Insulin, Globin Zinc Phase 4
26 insulin Phase 4
27
Pyridoxal Experimental, Nutraceutical Phase 4 66-72-8 1050
28
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
29
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
30
Vinorelbine Approved, Investigational Phase 3 71486-22-1 60780 44424639
31
Tocopherol Approved, Investigational Phase 3 1406-66-2, 54-28-4 14986
32
Acetylcholine Approved, Investigational Phase 3 51-84-3 187
33
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
34
Baclofen Approved Phase 3 1134-47-0 2284
35
Docetaxel Approved, Investigational Phase 3 114977-28-5 148124
36
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
37
Norepinephrine Approved Phase 2, Phase 3 51-41-2 439260
38
Dopamine Approved Phase 2, Phase 3 51-61-6, 62-31-7 681
39
Topotecan Approved, Investigational Phase 2, Phase 3 123948-87-8, 119413-54-6 60700
40
Bevacizumab Approved, Investigational Phase 2, Phase 3 216974-75-3
41
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
42
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
43
Olaparib Approved Phase 3 763113-22-0 23725625
44
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
45
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 43805 6857599 5310940 9887054
46
Amitriptyline Approved Phase 2, Phase 3 50-48-6 2160
47
Perphenazine Approved Phase 2, Phase 3 58-39-9 4748
48
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
49 Tocotrienol Investigational Phase 3 6829-55-6
50
Cediranib Investigational Phase 3 288383-20-0 9933475

Interventional clinical trials:

(show top 50) (show all 109)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double Blind, Placebo Controlled Prospective Study to Evaluate the Effectiveness of Monochromatic Infrared Photo Energy to Improve Diabetic Sensory Neuropathy Completed NCT00120341 Phase 4
2 A Prospective, Open-label Trial of Lidoderm® (Lidocaine Patch 5%)in Painful Diabetic and Idiopathic Neuropathy. Completed NCT00903851 Phase 4 Lidoderm
3 A 24 Week, Double-blind, Placebo-controlled, Multisite Study of Metanx® in Subjects With Type 2 Diabetic Peripheral Neuropathy (DPN) Completed NCT00726713 Phase 4
4 Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS) Completed NCT02260388 Phase 4 Nortriptyline;Duloxetine;Pregabalin;Mexiletine
5 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
6 Intensive Glycemic Control For Diabetic Foot Ulcer Healing: A Multicenter Randomized Control Study (IN-GLOBE Study) Not yet recruiting NCT04323462 Phase 4 Insulin Glargine;Diabetic DM
7 Randomized Phase 3 Study of Xelox(Capecitabine Plus Oxaliplatin) Followed by Maintenance Capecitabine or Observation in Patients With Advanced Gastric Adenocarcinoma Unknown status NCT02289547 Phase 3 Capecitabine
8 Phase III Study of Acetyl-L-Carnitine (ALC) Hydrochloride Enteric-coated Tablets in Treatment of Peripheral Sensory Neuropathy in Anti-cancer Chemotherapeutics Induce Completed NCT01526564 Phase 3 Acetylcarnitine;Placebo
9 A Multicenter Randomized Dble-Blind Placebo Controlled Phase III Study of the Efficacy of Xaliproden in Reducing the Neurotoxicity of the Oxaliplatin and 5-FU/LV Combination in First-Line Treatment of Patients With Metastatic Colorectal Carcinoma(MCRC) Completed NCT00272051 Phase 3 SR57746A
10 A Multicentre, Randomized, Open-label, Phase III Study Comparing the Efficacy of Oral Glutamine and Calcium-magnesium With Calcium-magnesium Alone in the Prevention of Oxaliplatin-induced Neurotoxicity in Patients With Colorectal Cancer Treated With Oxaliplatin in Adjuvant or 1st Line Metastatic Settings. Completed NCT01087658 Phase 3 Glutamine;Calcium and Magnesium
11 A Multicenter, Randomized Double-blind Placebo Controlled Phase III Study of the Efficacy of Xaliproden in Preventing the Neurotoxicity of Oxaliplatin in First-line Treatment of Patients With Metastatic Colorectal Cancer Treated With Oxaliplatin / 5-FU/LV Completed NCT00305188 Phase 3 Xaliproden (SR57746A);Placebo;Oxaliplatin;5-Fluorouracil;Leucovorin
12 A Randomized Phase III Study of Vitamins B6 and B12 to Prevent Chemotherapy-Induced Neuropathy in Cancer Patients. Completed NCT00659269 Phase 3 Chemotherapy
13 The Use of Vitamin E for Prevention of Chemotherapy Induced Peripheral Neuropathy: A Phase III Double-Blind Placebo Controlled Study Completed NCT00363129 Phase 3
14 PHASE III, Randomized, Double-blind, Placebo-controlled Clinical Trial to Evaluate the Efficacy and Safety of Pregabalin in Prevention and Reduction of Oxaliplatin-induced Painful Neuropathy Completed NCT01450163 Phase 3 Pregabalin, Oxaliplatin;Placebo , Oxaliplatin
15 The Use of Topical Baclofen, Amitriptyline HCI, and Ketamine (BAK) in a PLO Gel vs. Placebo for the Treatment of Chemotherapy Induced Peripheral Neuropathy: A Phase III Randomized Double-Blind Placebo Controlled Study Completed NCT00516503 Phase 3 baclofen/amitriptyline/ketamine gel
16 Efficacy and Safety of Xeomin for the Treatment of Notalgia Paresthetica Completed NCT01098019 Phase 3 Xeomin;Placebo / Xeomin
17 A Randomized, Phase III Clinical Trial to Compare Sentinel Node Resection to Conventional Axillary Dissection in Clinically Node-Negative Breast Cancer Patients Completed NCT00003830 Phase 3
18 Phase 2 Study for Infrared Thermometry Used by Diabetic Patients at Home Completed NCT00289497 Phase 2, Phase 3
19 ESSAI DE PHASE III RANDOMISE EVALUANT LE FOLFOX AVEC OU SANS DOCETAXEL (TFOX) EN 1ère LIGNE DE CHIMIOTHERAPIE DES ADENOCARCINOMES OESO-GASTRIQUES LOCALEMENT AVANCES OU METASTATIQUES Recruiting NCT03006432 Phase 3 Oxaliplatin;5Fluorouracil bolus;5Fluorouracil continu;Docetaxel;Folinic Acid
20 Duloxetine to Prevent Oxaliplatin-Induced Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Phase II to Phase III Study Recruiting NCT04137107 Phase 2, Phase 3 Oxaliplatin;Duloxetine Hydrochloride;Duloxetine
21 A Randomized Phase II/III Study of the Combination of Cediranib and Olaparib Compared to Cediranib or Olaparib Alone, or Standard of Care Chemotherapy in Women With Recurrent Platinum-Resistant or -Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (COCOS) Recruiting NCT02502266 Phase 2, Phase 3 Cediranib;Cediranib Maleate;Olaparib;Paclitaxel;Pegylated Liposomal Doxorubicin Hydrochloride;Topotecan;Topotecan Hydrochloride
22 A Phase III Study Comparing Single-Agent Olaparib or the Combination of Cediranib and Olaparib to Standard Platinum-Based Chemotherapy in Women With Recurrent Platinum-Sensitive Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Active, not recruiting NCT02446600 Phase 3 Carboplatin;Cediranib Maleate;Gemcitabine;Gemcitabine Hydrochloride;Olaparib;Paclitaxel;Pegylated Liposomal Doxorubicin Hydrochloride
23 Double-blind Placebo Controlled Trial of the Treatment of Chronic Laryngitis With Amitriptyline Suspended NCT02552225 Phase 2, Phase 3 Amitriptyline
24 A Randomized Phase III Trial of Eribulin Compared to Standard Weekly Paclitaxel as First- or Second-Line Therapy for Locally Recurrent or Metastatic Breast Cancer Suspended NCT02037529 Phase 3 Eribulin Mesylate;Paclitaxel
25 A Multi-center, Randomized, Double Blind, Placebo Controlled Phase III Study to Assess the Efficacy of Xaliproden in Patients With Oxaliplatin-induced Peripheral Sensory Neuropathy (PSN) Following Adjuvant Chemotherapy for Colon Cancer Terminated NCT00603577 Phase 3 Placebo;Xaliproden
26 Double-blind Placebo Controlled Trial of the Treatment of Chronic Laryngitis With Amitryptiline Terminated NCT02434523 Phase 2, Phase 3 Amitriptyline
27 Phase 3 Study: The Effect of Thalidomide in Suppression of the Systemic Inflammatory Response Syndrome in Hemodialysis Patients Terminated NCT00529633 Phase 3 Thalidomide
28 A Randomized, Double-Blinded, Placebo Controlled Phase III Trial Using Acetyl-L-Carnitine(ALC)(NSC# 747431) for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Patients With Recurrent Ovarian, Primary Peritoneal or Fallopian Tube Cancer Withdrawn NCT01492920 Phase 3
29 Prospective Comparison the Pharmacokinetics of Subcutaneous Versus Intravenous Administration of Bortezomib in Newly Diagnosed Patients of Multiple Myeloma in China. Unknown status NCT01812096 Phase 1, Phase 2
30 A Study of Prophylactic Oral Steroids for Fatigue and Malaise Due to Regorafenib Treatment for Unresectable Metastatic Colorectal Cancer: a Randomized, Placebo-controlled, Double-blind Phase 2 Clinical Study (KSCC1402/HGCSG1402) Unknown status NCT02288078 Phase 2 Dexamethasone;Regorafenib;Placebo;Proton pump inhibitor
31 Efficacy and Safety of Modified Nab-Paclitaxel Plus Gemcitabine Chemotherapy for Metastatic Pancreatic Cancer: A Single-arm Phase II Clinical Trial Unknown status NCT03502343 Phase 2 Modified Gemcitabine plus nab-Paclitaxel Combination Chemotherapy
32 The ELDORADO (Eligard®, Docetaxel and Radiotherapy) Study: A Phase II Study of Chemo - Hormonal Therapy and Radiation in High Risk Prostate Cancer Unknown status NCT00452556 Phase 2 Docetaxel;Leuprolide Acetate (Eligard®)
33 A Randomized Phase II Trial of Capecitabine Plus Cisplatin (XP) Versus Capecitabine Plus Paclitaxel (XT) as a First-line Treatment for Advanced or Recurrent Esophageal Squamous Cell Carcinoma Unknown status NCT00816634 Phase 2 Capecitabine plus cisplatin(XP) versus capecitabine plus paclitaxel(XT)
34 Effect of C-Peptide on Diabetic Peripheral Neuropathy, a 6 Months Randomized Double-Blind, Placebo Controlled, Dose-Finding, Multicenter Study, With Parallel Groups Completed NCT00278980 Phase 2 C-peptide
35 A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of L-Serine in Subjects With Hereditary Sensory Neuropathy Type 1 Completed NCT01733407 Phase 1, Phase 2 L-serine;placebo
36 A Phase II, Double-Blind Trial of Recombinant Human Nerve Growth Factor for Treatment of HIV-Associated Sensory Neuropathy Completed NCT00000842 Phase 2 Nerve Growth Factor, Recombinant Human
37 Phase II Trial of Metronomic Eribulin (Halaven) in Pretreated Metastatic Breast Cancer (MBC) Completed NCT01908101 Phase 2 Eribulin Mesylate
38 The Efficacy of MC5-A ("Scrambler") Therapy in the Management of Chemotherapy-Induced Peripheral Neuropathy: A Phase II Pilot Trial Completed NCT00952848 Phase 2
39 VELCADE (Bortezomib) and Thalidomide in Newly Diagnosed Patients With Multiple Myeloma Completed NCT00287872 Phase 2 bortezomib;thalidomide
40 Phase 2 Study of Ascorbic Acid Treatment in Charcot-Marie-Tooth Type 1A Completed NCT00271635 Phase 2 Placebo;ascorbic acid
41 Topiramate as a Disease Modifying Therapy for Cryptogenic Sensory Peripheral Neuropathy in Metabolic Syndrome (CSPN) Recruiting NCT02878798 Phase 2 topiramate
42 Nicotinamide Riboside (NR) in Paclitaxel-induced Peripheral Neuropathy Recruiting NCT03642990 Phase 2 Nicotinamide Riboside
43 Symptom Management Efficacy Study to Reduce Distal Neuropathic Pain Recruiting NCT03855111 Phase 2
44 Phase II Evaluation of the Effect of 2 Versus 6 Hour Oxaliplatin Infusions on Neuropathy and Pharmacokinetics in Patients With Gastrointestinal Cancers Recruiting NCT03800693 Phase 2 Fluorouracil;Leucovorin;Oxaliplatin
45 A Phase IIa Proof of Concept, Randomized, Double-blind, Placebo-controlled Study of the Effects of L-serine on Early Stage Alzheimer's Disease Patients Recruiting NCT03062449 Phase 2 L-Serine
46 Randomized Phase II Study Comparing 5FU/LV+Nal-IRI, Gemcitabine+Nab-paclitaxel or a Sequential Regimen of 2 Months 5FU/LV+Nal-IRI Followed by Two Months of Gemcitabine+Nab-paclitaxel, in Metastatic Pancreatic Cancer Recruiting NCT03693677 Phase 2 Irinotecan Liposomal Injection;5-FU/LV;Nab-Paclitaxel;Gemcitabine
47 Phase II Trial of Infusional 5 FLUOROURACIL, LEUCOVORIN, OXALIPLATIN AND IRINOTECAN (FOLFIRINOX) in First Line Treatment of Advanced Biliary Tract Cancers Recruiting NCT03291899 Phase 2
48 Botulinum Toxin A for the Treatment of Chemotherapy Induced Peripheral Neuropathy Not yet recruiting NCT03571334 Phase 2 IncobotulinumtoxinA (Xeomin®, Merz) (INA);Normal saline
49 Phase II Trial of Modified FOLFIRINOX in Patients With Metastatic Biliary Tract Cancer After Failure of Gemcitabine/Cisplatin Chemotherapy Not yet recruiting NCT03778593 Phase 2 5-Fluorouracil;Leucovorin;Irinotecan;Oxaliplatin
50 Phase II Study to Assess Prevention of Oxaliplatin-induced Neurotoxicity Through the Vitamin D Pathway Terminated NCT01499940 Phase 2 Vitamin D3

Search NIH Clinical Center for Sensory Peripheral Neuropathy

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Genetic Tests for Sensory Peripheral Neuropathy

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Genetic tests related to Sensory Peripheral Neuropathy:

# Genetic test Affiliating Genes
1 Sensory Neuropathy 29
Sources

Anatomical Context for Sensory Peripheral Neuropathy

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MalaCards organs/tissues related to Sensory Peripheral Neuropathy:

40
Breast, Lung, Skin, Brain, Spinal Cord, Colon, Testes
Sources

Publications for Sensory Peripheral Neuropathy

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Articles related to Sensory Peripheral Neuropathy:

(show top 50) (show all 4122)
# Title Authors PMID Year
1
Atypical, perhaps under-recognized? An unusual phenotype of Friedreich ataxia. 61 54
20162437 2010
2
Six new gap junction beta 1 gene mutations and their phenotypic expression in Czech patients with Charcot-Marie-Tooth disease. 54 61
20039784 2010
3
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Early onset severe and late-onset mild Charcot-Marie-Tooth disease with mitofusin 2 (MFN2) mutations. 61 54
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Sources

Variations for Sensory Peripheral Neuropathy

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ClinVar genetic disease variations for Sensory Peripheral Neuropathy:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 GDAP1 NM_018972.4(GDAP1):c.715C>T (p.Leu239Phe)SNV Pathogenic 4200 rs104894080 8:75276240-75276240 8:74364005-74364005
2 MPZ NM_000530.8(MPZ):c.293G>A (p.Arg98His)SNV Pathogenic/Likely pathogenic 14176 rs121913589 1:161276653-161276653 1:161306863-161306863
3 SPTLC3 NM_018327.4(SPTLC3):c.448T>C (p.Trp150Arg)SNV Likely pathogenic 243088 rs755919784 20:13053048-13053048 20:13072400-13072400
4 GJB1 NM_000166.6(GJB1):c.502T>G (p.Cys168Gly)SNV Likely pathogenic 373934 rs1057518780 X:70444059-70444059 X:71224209-71224209
5 MED25 NM_030973.3(MED25):c.1778_1779del (p.Gln593fs)deletion Uncertain significance 409952 rs763039409 19:50339015-50339016 19:49835758-49835759
6 AP1B1 NM_001127.3(AP1B1):c.637G>A (p.Glu213Lys)SNV Uncertain significance 598986 rs1569159579 22:29752494-29752494 22:29356505-29356505
7 SLC12A1 NM_000338.3(SLC12A1):c.2255C>T (p.Ala752Val)SNV Uncertain significance 316268 rs137893258 15:48559858-48559858 15:48267661-48267661
8 POMT1 NM_001077365.2(POMT1):c.1793G>A (p.Arg598Gln)SNV Uncertain significance 373970 rs202140413 9:134396827-134396827 9:131521440-131521440
9 SCN11A NM_001349253.2(SCN11A):c.4628G>A (p.Cys1543Tyr)SNV Likely benign 701958 3:38888933-38888933 3:38847442-38847442
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Expression for Sensory Peripheral Neuropathy

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Search GEO for disease gene expression data for Sensory Peripheral Neuropathy.
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Pathways for Sensory Peripheral Neuropathy

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Pathways related to Sensory Peripheral Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Guidance Cues and Growth Cone Motility 63
11.4 NGF MAG GDAP1
2
Neural Crest Differentiation 1
11.14 PMP22 MPZ GJB1
3
p75(NTR)-mediated signaling 1
Show member pathways
 10.62 NTF3 NGF MAG
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GO Terms for Sensory Peripheral Neuropathy

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Cellular components related to Sensory Peripheral Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 compact myelin GO:0043218 8.62 PMP22 MAG

Biological processes related to Sensory Peripheral Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.77 NTF3 MAG GJB1 ELAVL4 ELAVL3
2 positive regulation of myelination GO:0031643 9.46 MAG EGR2
3 mitochondrial fusion GO:0008053 9.43 MFN2 GDAP1
4 nerve development GO:0021675 9.4 NTF3 NGF
5 nerve growth factor signaling pathway GO:0038180 9.32 NTF3 NGF
6 myelin assembly GO:0032288 9.26 PMP22 MTMR2
7 peripheral nervous system myelin maintenance GO:0032287 9.16 PRX NDRG1
8 myelination GO:0042552 9.13 PMP22 MPZ EGR2
9 peripheral nervous system development GO:0007422 8.92 PMP22 NTF3 NGF EGR2

Molecular functions related to Sensory Peripheral Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nerve growth factor receptor binding GO:0005163 8.62 NTF3 NGF
Sources

Sources for Sensory Peripheral Neuropathy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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