MCID: SNS023
MIFTS: 34

Sensory System Cancer

Categories: Neuronal diseases, Cancer diseases

Aliases & Classifications for Sensory System Cancer

MalaCards integrated aliases for Sensory System Cancer:

Name: Sensory System Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060116

Summaries for Sensory System Cancer

Disease Ontology : 12 A nervous system cancer that is located in the sensory system.

MalaCards based summary : Sensory System Cancer is related to vulvar adenocarcinoma and glioblastoma proneural subtype. An important gene associated with Sensory System Cancer is RB1 (RB Transcriptional Corepressor 1), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. Affiliated tissues include the sensory system, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Sensory System Cancer

Diseases related to Sensory System Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 vulvar adenocarcinoma 11.1 RB1 TP53
2 glioblastoma proneural subtype 11.0 CDK4 CDK6
3 breast papillomatosis 11.0 CCND1 CDKN2A
4 brain stem astrocytic neoplasm 11.0 CDKN2A TP53
5 phakomatosis cesioflammea 11.0 GNA11 GNAQ
6 ewing's family of tumors 10.9 CDK4 CDKN2A RB1
7 oral leukoplakia 10.9 CCND1 CDKN2A TP53
8 endometrial squamous cell carcinoma 10.9 CCND1 CDK6 CDKN2A
9 intraocular melanoma 10.9 GNA11 GNAQ
10 pre-malignant neoplasm 10.9 CCND1 CDKN2A TP53
11 zika virus infection 10.9 MDM2 TP53
12 spindle cell lipoma 10.9 CDK4 MDM2 RB1
13 gastrointestinal system benign neoplasm 10.9 CCND1 CDKN2A TP53
14 chondromyxoid fibroma 10.8 CCND1 CDKN1A CDKN2A
15 ring chromosome 7 10.8 CDK4 MDM2 TP53
16 penile cancer 10.8 CCND1 CDKN2A TP53
17 unilateral retinoblastoma 10.8 RB1 RBL1
18 pharynx cancer 10.8 CCND1 CDKN2A TP53
19 infiltrating angiolipoma 10.8 CDK4 CDKN2A MDM2
20 bladder carcinoma in situ 10.8 CCND3 CDKN2A TP53
21 megaesophagus 10.8 CDKN2A MYC TP53
22 melanomatosis 10.8 CDKN2A GNA11 GNAQ
23 actinic cheilitis 10.8 CDKN1A MDM2 TP53
24 tongue cancer 10.8 CDKN1A CDKN2A TP53
25 periosteal osteogenic sarcoma 10.8 CDK4 MDM2 TP53
26 atypical lipomatous tumor 10.8 CDK4 CDKN2A MDM2
27 cervical adenocarcinoma 10.8 CDKN1A CDKN2A TP53
28 well-differentiated liposarcoma 10.8 CDK4 CDKN2A MDM2
29 small cell sarcoma 10.8 CDK4 MDM2 TP53
30 embryonal sarcoma 10.8 CDK4 MDM2 TP53
31 integumentary system cancer 10.8 CDKN2A GNAQ TP53
32 cell type benign neoplasm 10.8 CCND1 CDKN2A TP53
33 meningeal melanocytoma 10.8 CDKN2A GNA11 GNAQ
34 hepatic angiomyolipoma 10.8 MYC RB1
35 central nervous system melanocytic neoplasm 10.7 CDKN2A GNA11 GNAQ
36 undifferentiated embryonal sarcoma of the liver 10.7 CDK4 MDM2
37 gallbladder adenoma 10.7 CDKN2A RB1
38 splenic diffuse red pulp small b-cell lymphoma 10.7 CCND3 TP53
39 schneiderian carcinoma 10.7 CDKN2A RBL2 TP53
40 malignant fibrous histiocytoma of bone 10.7 CDK4 MDM2 MYC
41 connective tissue cancer 10.7 CDK4 MDM2 TP53
42 oral cancer 10.7 CCND1 CDKN2A TP53
43 melanoma, cutaneous malignant 1 10.7 CDK4 CDK6 CDKN2A TP53
44 cellular schwannoma 10.7 CDKN2A MDM2 TP53
45 gliosarcoma 10.7 CCND3 CDK4 RB1 TP53
46 periosteal chondrosarcoma 10.7 CDK4 CDKN2A MDM2 RB1
47 myxoid liposarcoma 10.7 CDK4 MDM2 TP53
48 keratinizing squamous cell carcinoma 10.7 CDKN2A TP53
49 male reproductive organ cancer 10.7 CCND1 MYC TP53
50 histiocytoma 10.7 CDK4 MDM2 TP53

Graphical network of the top 20 diseases related to Sensory System Cancer:



Diseases related to Sensory System Cancer

Symptoms & Phenotypes for Sensory System Cancer

GenomeRNAi Phenotypes related to Sensory System Cancer according to GeneCards Suite gene sharing:

26 (show all 35)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.36 CDK2 MDM2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.36 CDK2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.36 CCND1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-13 10.36 CDK2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-136 10.36 MDM2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.36 MDM2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.36 CCND1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.36 CDK2 MDM2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.36 CCND1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-163 10.36 CCND1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.36 MDM2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.36 CCND1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.36 MYC
14 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.36 CCND1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.36 CCND1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.36 CCND1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-24 10.36 MYC
18 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.36 CCND1 CDK2 MDM2 MYC
19 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.36 CCND1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-41 10.36 CDK2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.36 CDK2 MDM2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.36 CDK2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.36 CDK2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.36 MDM2
25 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.36 MYC
26 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.36 CDK2
27 Decreased viability GR00221-A-1 10.3 CDKN1B CDKN2A E2F1 CDK6 RBL1 RBL2
28 Decreased viability GR00221-A-2 10.3 E2F1 CDK6 RBL1
29 Decreased viability GR00221-A-3 10.3 CDKN2A MYC
30 Decreased viability GR00221-A-4 10.3 CDK6 CDKN2A
31 Decreased viability GR00301-A 10.3 CDK6
32 Decreased viability GR00402-S-2 10.3 CDKN1B CDKN2A E2F1 CDK6 RBL1 RBL2
33 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.47 CDKN1A CDKN2A CDK2 E2F1 RB1 TP53
34 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.47 CCND1 CDKN1A CDKN2A CDK2 E2F1 MYC
35 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.43 CDKN1A CDKN1B CDK2 E2F3 MDM2 TP53

MGI Mouse Phenotypes related to Sensory System Cancer:

46 (show all 28)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.61 GNAQ MYC MDM2 CCND1 CDK2 CDK4
2 endocrine/exocrine gland MP:0005379 10.58 GNAQ MYC MDM2 CCND1 CDK2 CDK4
3 growth/size/body region MP:0005378 10.57 MDM2 GNAQ CCND1 CDK2 CCND3 CDK4
4 behavior/neurological MP:0005386 10.54 GNA11 MDM2 GNAQ CCND3 CCND1 MYC
5 cellular MP:0005384 10.53 MDM2 CCND1 CDK2 MYC RB1 RBL2
6 homeostasis/metabolism MP:0005376 10.52 GNA11 MDM2 GNAQ CCND3 CCND1 CDK2
7 hematopoietic system MP:0005397 10.51 MDM2 GNAQ GNA11 CCND1 CDK2 CCND3
8 immune system MP:0005387 10.51 MDM2 GNAQ CCND1 CDK2 CCND3 CDK4
9 mortality/aging MP:0010768 10.51 MDM2 GNAQ CCND1 CDK2 CCND3 CDK4
10 embryo MP:0005380 10.48 MDM2 CDK2 RB1 MYC RBL2 RBL1
11 integument MP:0010771 10.48 MDM2 GNAQ CCND1 CDK2 CDK4 RB1
12 craniofacial MP:0005382 10.43 MDM2 GNAQ CCND1 RB1 MYC RBL2
13 digestive/alimentary MP:0005381 10.42 MDM2 CCND1 RB1 MYC RBL1 CDK4
14 neoplasm MP:0002006 10.41 MDM2 CCND1 CDK2 CDK4 CCND3 PRDM2
15 muscle MP:0005369 10.37 MDM2 GNAQ CDK2 CDK4 RB1 MYC
16 liver/biliary system MP:0005370 10.34 MDM2 GNA11 CDK2 CCND3 RB1 MYC
17 nervous system MP:0003631 10.33 GNA11 MDM2 GNAQ CCND1 MYC RB1
18 hearing/vestibular/ear MP:0005377 10.32 GNAQ GNA11 RB1 MYC RBL2 RBL1
19 normal MP:0002873 10.25 GNA11 MDM2 GNAQ CCND3 CCND1 RB1
20 adipose tissue MP:0005375 10.24 MYC RB1 RBL1 CDKN1A TP53 CDKN1B
21 limbs/digits/tail MP:0005371 10.19 GNA11 MDM2 GNAQ MYC RB1 RBL2
22 reproductive system MP:0005389 10.16 MDM2 CCND1 CDK2 CDK4 MYC RB1
23 no phenotypic analysis MP:0003012 10.13 MDM2 MYC RB1 RBL2 RBL1 CDKN1A
24 pigmentation MP:0001186 10.02 GNA11 MDM2 GNAQ MYC RB1 CDK4
25 renal/urinary system MP:0005367 10.02 GNA11 MDM2 GNAQ RB1 RBL2 RBL1
26 respiratory system MP:0005388 10 GNAQ CCND1 CCND3 RB1 RBL1 TP53
27 skeleton MP:0005390 9.83 MDM2 GNAQ GNA11 CCND1 RB1 MYC
28 vision/eye MP:0005391 9.44 CCND3 CCND1 CDK2 RB1 RBL2 RBL1

Drugs & Therapeutics for Sensory System Cancer

Search Clinical Trials , NIH Clinical Center for Sensory System Cancer

Genetic Tests for Sensory System Cancer

Anatomical Context for Sensory System Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Sensory System Cancer:

19
The Sensory System

Publications for Sensory System Cancer

Variations for Sensory System Cancer

Expression for Sensory System Cancer

Search GEO for disease gene expression data for Sensory System Cancer.

Pathways for Sensory System Cancer

Pathways related to Sensory System Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.31 CCND1 CCND3 CDK2 CDK4 CDKN1A CDKN1B
2
Show member pathways
14.07 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1A
3
Show member pathways
13.94 CCND1 CCND3 CDK2 CDK4 CDKN1A CDKN1B
4
Show member pathways
13.93 CDK2 CDKN1A CDKN1B CDKN2A E2F1 E2F4
5
Show member pathways
13.69 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1A
6
Show member pathways
13.39 CDK2 CDK4 CDK6 CDKN1A CDKN1B CDKN2A
7
Show member pathways
13.31 CCND1 CDK2 CDK4 CDK6 CDKN1A CDKN1B
8
Show member pathways
13.23 CDK2 CDKN1A CDKN1B CDKN2A E2F1 E2F4
9
Show member pathways
13.22 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1A
10 13.21 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1A
11
Show member pathways
13.08 CCND1 CDK2 CDK4 CDK6 CDKN1A CDKN1B
12
Show member pathways
13.08 CCND1 CDK2 CDK4 CDK6 CDKN1A CDKN1B
13
Show member pathways
13.05 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1A
14
Show member pathways
13.04 CCND1 CDK2 CDK4 CDK6 CDKN1A CDKN1B
15
Show member pathways
12.97 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1B
16
Show member pathways
12.94 CCND1 CDK2 CDK4 CDKN1A CDKN1B E2F1
17
Show member pathways
12.93 CCND1 CDKN1B E2F1 E2F3 E2F4 MYC
18
Show member pathways
12.92 CCND1 E2F1 E2F3 MYC TP53
19
Show member pathways
12.9 CCND1 CDK2 CDK4 CDK6 CDKN1A CDKN1B
20 12.9 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1A
21
Show member pathways
12.88 CDKN1A CDKN2A MDM2 MYC TP53
22 12.84 CCND1 CDK6 CDKN1A CDKN1B CDKN2A E2F1
23
Show member pathways
12.8 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1A
24 12.79 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1A
25 12.76 CCND1 CCND3 CDK4 CDKN1A CDKN2A E2F1
26
Show member pathways
12.74 CDK2 CDKN1A CDKN1B MDM2 TP53
27
Show member pathways
12.7 CCND1 CDKN1B MDM2 MYC RB1 TP53
28 12.7 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1A
29
Show member pathways
12.68 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1A
30
Show member pathways
12.67 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1B
31
Show member pathways
12.66 CCND1 CDKN1A CDKN1B MDM2 MYC TP53
32
Show member pathways
12.61 E2F1 E2F3 E2F4 GNA11 RB1
33
Show member pathways
12.6 CCND1 CDK2 CDK4 CDKN1A E2F1 E2F3
34
Show member pathways
12.59 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1A
35 12.56 CDK2 CDKN1A CDKN1B MDM2 MYC RB1
36 12.55 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1A
37 12.51 CCND1 CDK2 CDK4 CDKN1A CDKN1B E2F1
38
Show member pathways
12.5 CDK2 CDKN1A CDKN1B RB1 TP53
39 12.47 CCND1 CDK2 CDK4 E2F1 MDM2 MYC
40 12.45 CCND1 CDKN1A MDM2 MYC TP53
41 12.45 CCND1 CDK2 CDK4 CDK6 CDKN1A CDKN1B
42
Show member pathways
12.41 CCND1 GNA11 GNAQ MYC
43 12.41 CDKN1A CDKN1B MDM2 MYC TP53
44
Show member pathways
12.41 CCND1 CCND3 CDK4 E2F1 E2F4 MYC
46 12.37 CCND1 CDKN1A E2F4 MYC RBL1 RBL2
47 12.36 CCND1 CDKN1A E2F4 MYC TP53
48 12.35 CCND1 CDK2 CDK4 CDKN1B E2F1 MYC
49
Show member pathways
12.34 CCND1 CDK2 CDKN1A CDKN1B MDM2 RBL2
50 12.34 CDK2 CDKN1A CDKN2A E2F1 MDM2 RB1

GO Terms for Sensory System Cancer

Cellular components related to Sensory System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleolus GO:0005730 9.95 CDK4 CDKN1A CDKN2A MDM2 MYC RBL2
2 nucleoplasm GO:0005654 9.89 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1A
3 transcription factor complex GO:0005667 9.76 CDK2 CDK4 E2F1 E2F3 E2F4 RB1
4 nuclear chromatin GO:0000790 9.73 E2F1 E2F4 MYC TP53
5 chromatin GO:0000785 9.62 CDK4 RB1 RBL1 RBL2
6 Rb-E2F complex GO:0035189 9.37 E2F1 RB1
7 cyclin-dependent protein kinase holoenzyme complex GO:0000307 9.1 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1A
8 nucleus GO:0005634 10.23 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1A

Biological processes related to Sensory System Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.99 CDKN1A MDM2 MYC RB1 RBL1 RBL2
2 negative regulation of cell growth GO:0030308 9.97 CDKN1A CDKN1B CDKN2A TP53
3 cellular response to hypoxia GO:0071456 9.97 E2F1 MDM2 MYC TP53
4 response to organic substance GO:0010033 9.95 CCND1 CDK2 CDK4 CDKN1A
5 regulation of cell cycle GO:0051726 9.91 CCND1 CCND3 CDK2 CDK4 CDKN1A E2F1
6 regulation of G2/M transition of mitotic cell cycle GO:0010389 9.9 CDK2 CDK6 CDKN2A
7 cellular response to organic cyclic compound GO:0071407 9.9 CDKN1B MDM2 MYC
8 negative regulation of epithelial cell proliferation GO:0050680 9.89 CDK6 CDKN1B RB1
9 regulation of mitotic cell cycle GO:0007346 9.89 CDKN1A MYC RB1 RBL1 RBL2
10 protein kinase B signaling GO:0043491 9.87 CDKN1A CDKN1B MDM2
11 cell cycle arrest GO:0007050 9.87 CDK6 CDKN1A CDKN1B CDKN2A MYC RB1
12 animal organ regeneration GO:0031100 9.86 CCND1 CDK4 CDKN1A
13 negative regulation of cell cycle GO:0045786 9.86 CDK6 CDKN1B RB1
14 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.85 CDKN1A RB1 RBL1 RBL2
15 Ras protein signal transduction GO:0007265 9.85 CDK2 CDKN1A CDKN2A RB1 TP53
16 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737 9.84 CCND1 CCND3 CDKN1B
17 cellular response to gamma radiation GO:0071480 9.83 CDKN1A MDM2 TP53
18 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.82 CDKN1A CDKN1B CDKN2A
19 response to X-ray GO:0010165 9.8 CCND1 CDKN1A TP53
20 negative regulation of cell cycle arrest GO:0071157 9.8 CCND1 CDK4 MDM2
21 positive regulation of fibroblast proliferation GO:0048146 9.8 CDK4 CDK6 CDKN1A E2F1 MYC
22 negative regulation of phosphorylation GO:0042326 9.77 CDKN1A CDKN1B CDKN2A
23 positive regulation of cell cycle GO:0045787 9.77 CCND1 CDK4 CDKN1B MDM2 MYC
24 replicative senescence GO:0090399 9.76 CDKN1A CDKN2A TP53
25 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.76 CDK2 CDKN1A CDKN1B E2F1 E2F4 MDM2
26 cellular response to estrogen stimulus GO:0071391 9.74 MDM2 MYC
27 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.74 GNA11 GNAQ
28 response to hyperoxia GO:0055093 9.74 CDK4 CDKN1A
29 determination of adult lifespan GO:0008340 9.73 PRDM2 TP53
30 developmental pigmentation GO:0048066 9.73 GNA11 GNAQ
31 response to magnesium ion GO:0032026 9.73 CCND1 MDM2
32 regulation of insulin receptor signaling pathway GO:0046626 9.73 CCND3 CDK4
33 cellular response to antibiotic GO:0071236 9.73 CDKN1B MDM2
34 mitotic G1 DNA damage checkpoint GO:0031571 9.73 CCND1 CDK2 TP53
35 amyloid fibril formation GO:1990000 9.72 CDKN2A MDM2
36 phototransduction, visible light GO:0007603 9.72 GNA11 GNAQ
37 entrainment of circadian clock GO:0009649 9.72 GNA11 GNAQ
38 negative regulation of monocyte differentiation GO:0045656 9.71 CDK6 MYC
39 re-entry into mitotic cell cycle GO:0000320 9.71 CCND1 MYC
40 signal transduction by p53 class mediator GO:0072331 9.7 CDKN1A TP53
41 negative regulation of fat cell proliferation GO:0070345 9.7 E2F1 E2F3
42 cellular response to xenobiotic stimulus GO:0071466 9.7 E2F1 RB1
43 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.7 CDK4 CDK6 CDKN2A
44 cellular response to phorbol 13-acetate 12-myristate GO:1904628 9.69 CDK4 MYC
45 negative regulation of cyclin-dependent protein kinase activity GO:1904030 9.68 CDKN1A CDKN1B
46 cellular response to actinomycin D GO:0072717 9.68 MDM2 TP53
47 negative regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0071930 9.67 E2F1 RB1
48 regulation of melanocyte differentiation GO:0045634 9.65 GNA11 GNAQ
49 regulation of lipid kinase activity GO:0043550 9.65 RB1 RBL1 RBL2
50 G1/S transition of mitotic cell cycle GO:0000082 9.61 CCND1 CDK2 CDK4 CDK6 CDKN1A CDKN1B

Molecular functions related to Sensory System Cancer according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.95 CCND1 CCND3 CDKN1A CDKN1B CDKN2A E2F1
2 protein dimerization activity GO:0046983 9.86 E2F1 E2F3 E2F4 MYC
3 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0001228 9.81 E2F3 E2F4 PRDM2 TP53
4 transcription factor binding GO:0008134 9.76 CCND1 CDKN2A E2F1 E2F4 MYC RB1
5 core promoter binding GO:0001047 9.71 E2F1 E2F3 RB1
6 RNA polymerase II activating transcription factor binding GO:0001102 9.7 RB1 RBL1 RBL2
7 promoter-specific chromatin binding GO:1990841 9.62 E2F4 RBL1 RBL2 TP53
8 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.61 CDKN1A CDKN1B CDKN2A
9 disordered domain specific binding GO:0097718 9.56 CDKN2A MDM2 RB1 TP53
10 RNA polymerase II regulatory region DNA binding GO:0001012 9.54 RB1 RBL1 RBL2
11 type 2A serotonin receptor binding GO:0031826 9.49 GNA11 GNAQ
12 cyclin binding GO:0030332 9.35 CDK2 CDK4 CDK6 CDKN1A CDKN1B
13 cyclin-dependent protein serine/threonine kinase activity GO:0004693 9.17 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1A
14 protein binding GO:0005515 10.43 CCND1 CCND3 CDK2 CDK4 CDK6 CDKN1A
15 DNA binding GO:0003677 10.22 CDKN2A E2F1 E2F3 E2F4 MYC PRDM2
16 DNA binding transcription factor activity GO:0003700 10.09 E2F1 E2F3 E2F4 MYC PRDM2 RB1
17 kinase activity GO:0016301 10.02 CCND1 CDK2 CDK4 CDK6 CDKN1A CDKN1B

Sources for Sensory System Cancer

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9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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32 HPO
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34 ICD10 via Orphanet
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
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