Sensory System Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Sensory System Disease

MalaCards integrated aliases for Sensory System Disease:

Name: Sensory System Disease ¹¹ ¹⁴ ¹⁶

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Smell/Taste diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0050155

EFO ¹⁶ EFO_0001058

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Summaries for Sensory System Disease

Disease Ontology: ¹¹ A nervous system disease which is located in a part of the nervous system responsible for processing sensory information that consists of sensory receptors, neural pathways, and parts of the brain involved in sensory perception. Commonly recognized sensory systems are those for vision, hearing, somatic sensation (touch), taste and olfaction (smell).

MalaCards based summary: Sensory System Disease is related to leber congenital amaurosis with early-onset deafness and auditory system disease. An important gene associated with Sensory System Disease is CRYAA (Crystallin Alpha A), and among its related pathways/superpathways are miRNAs involved in DNA damage response and Cell differentiation - expanded index. Affiliated tissues include brain.

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Related Diseases for Sensory System Disease

Diseases related to Sensory System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 404)

#	Related Disease	Score	Top Affiliating Genes
1	leber congenital amaurosis with early-onset deafness	11.0
2	auditory system disease	11.0
3	nervous system disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
4	connective tissue disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
5	eye disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
6	retinal disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR21 MIR20A MIR204
7	myopathy	10.7	U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR142
8	chromosomal disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
9	muscular disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
10	central nervous system disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
11	peripheral nervous system disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR199A1
12	muscle tissue disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR142
13	physical disorder	10.7	U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
14	urinary system disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
15	disease of mental health	10.7	U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
16	leukocyte disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
17	uveal disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR199A1 MIR17 MIR142
18	leukemia, acute myeloid	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR204
19	respiratory system disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
20	skin disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
21	reproductive system disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
22	eye degenerative disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR17 MIR142 MIR140
23	endocrine system disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
24	immune system disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
25	bladder disease	10.7	U2AF1 MIR9-1 MIR34A MIR21 MIR204 MIR199A1
26	female reproductive system disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
27	inherited metabolic disorder	10.7	SERPINA3 MIR9-1 MIR34A MIR21 MIR20A MIR204
28	integumentary system disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
29	malignant ovarian surface epithelial-stromal neoplasm	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR199A1
30	glucose metabolism disease	10.7	SERPINA3 MIR9-1 MIR34A MIR21 MIR20A MIR204
31	carbohydrate metabolic disorder	10.7	SERPINA3 MIR9-1 MIR34A MIR21 MIR20A MIR204
32	amyotrophic lateral sclerosis 1	10.7	U2AF1 SERPINA3 MIR9-1 MIR199A1 MIR17 MIR142
33	male reproductive organ cancer	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
34	breast disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
35	pancreas disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
36	connective tissue cancer	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
37	head and neck cancer	10.7	U2AF1 MIR9-1 MIR34A MIR21 MIR20A MIR204
38	spinal disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
39	lung cancer	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
40	respiratory system cancer	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
41	arteries, anomalies of	10.7	SERPINA3 MIR9-1 MIR34A MIR21 MIR20A MIR204
42	cervix carcinoma	10.7	U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR142
43	leukemia, chronic lymphocytic	10.7	U2AF1 MIR9-1 MIR34A MIR21 MIR20A MIR199A1
44	immune deficiency disease	10.7	SERPINA3 MIR9-1 MIR34A MIR21 MIR20A MIR199A1
45	autoimmune disease of central nervous system	10.7	SERPINA3 MIR9-1 MIR21 MIR199A1 MIR142 MIR140
46	gastrointestinal system disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
47	lymphatic system disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
48	biliary tract disease	10.7	SERPINA3 MIR9-1 MIR21 MIR204 MIR199A1 MIR17
49	peripheral nervous system neoplasm	10.7	U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR199A1
50	bile duct adenocarcinoma	10.7	SERPINA3 MIR9-1 MIR21 MIR204 MIR199A1 MIR17

Graphical network of the top 20 diseases related to Sensory System Disease:

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Symptoms & Phenotypes for Sensory System Disease

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Drugs & Therapeutics for Sensory System Disease

Search Clinical Trials, NIH Clinical Center for Sensory System Disease

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Genetic Tests for Sensory System Disease

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Anatomical Context for Sensory System Disease

Organs/tissues related to Sensory System Disease:

MalaCards : Brain

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Publications for Sensory System Disease

Articles related to Sensory System Disease:

#	Title	Authors	PMID	Year
1	X-linked infantile periodic alternating nystagmus. ⁶²	Hertle RW...Seward A	16020310	2005

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Genes for Sensory System Disease

Genes related to Sensory System Disease (0 elite genes):

(show top 50) (show all 118)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CRYAA	Crystallin Alpha A	Protein Coding	14.1	DISEASES inferred ¹⁴ ¹⁴
2	H2AC18	H2A Clustered Histone 18	Protein Coding	12.41	DISEASES inferred ¹⁴ ¹⁴
3	ERCC6	ERCC Excision Repair 6, Chromatin Remodeling Factor	Protein Coding	11.29	DISEASES inferred ¹⁴ ¹⁴
4	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	11	DISEASES inferred ¹⁴ ¹⁴
5	MIR21	MicroRNA 21	RNA Gene	10.83	DISEASES inferred ¹⁴ ¹⁴
6	CFHR2	Complement Factor H Related 2	Protein Coding	10.67	DISEASES inferred ¹⁴ ¹⁴
7	U2AF1	U2 Small Nuclear RNA Auxiliary Factor 1	Protein Coding	10.66	DISEASES inferred ¹⁴ ¹⁴
8	MIR17	MicroRNA 17	RNA Gene	10.55	DISEASES inferred ¹⁴ ¹⁴
9	MIR199A1	MicroRNA 199a-1	RNA Gene	10.25	DISEASES inferred ¹⁴ ¹⁴
10	SERPINA3	Serpin Family A Member 3	Protein Coding	10.21	DISEASES inferred ¹⁴ ¹⁴
11	MIR9-1	MicroRNA 9-1	RNA Gene	10.18	DISEASES inferred ¹⁴ ¹⁴
12	MIR126	MicroRNA 126	RNA Gene	10.16	DISEASES inferred ¹⁴ ¹⁴
13	MIR204	MicroRNA 204	RNA Gene	9.96	DISEASES inferred ¹⁴ ¹⁴
14	EPRS1	Glutamyl-Prolyl-TRNA Synthetase 1	Protein Coding	9.84	DISEASES inferred ¹⁴ ¹⁴
15	MIR142	MicroRNA 142	RNA Gene	9.77	DISEASES inferred ¹⁴ ¹⁴
16	MIR140	MicroRNA 140	RNA Gene	9.67	DISEASES inferred ¹⁴ ¹⁴
17	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	9.66	DISEASES inferred ¹⁴ ¹⁴
18	MIR20A	MicroRNA 20a	RNA Gene	9.65	DISEASES inferred ¹⁴ ¹⁴
19	APC	APC Regulator Of WNT Signaling Pathway	Protein Coding	9.55	DISEASES inferred ¹⁴ ¹⁴
20	MIR34A	MicroRNA 34a	RNA Gene	9.54	DISEASES inferred ¹⁴ ¹⁴
21	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	9.53	DISEASES inferred ¹⁴
22	MIR155	MicroRNA 155	RNA Gene	9.52	DISEASES inferred ¹⁴ ¹⁴
23	MIR30A	MicroRNA 30a	RNA Gene	9.51	DISEASES inferred ¹⁴ ¹⁴
24	MIR125A	MicroRNA 125a	RNA Gene	9.44	DISEASES inferred ¹⁴ ¹⁴
25	MIR146A	MicroRNA 146a	RNA Gene	9.43	DISEASES inferred ¹⁴ ¹⁴
26	MIR29B1	MicroRNA 29b-1	RNA Gene	9.43	DISEASES inferred ¹⁴ ¹⁴
27	MIR223	MicroRNA 223	RNA Gene	9.38	DISEASES inferred ¹⁴ ¹⁴
28	MIR27A	MicroRNA 27a	RNA Gene	9.38	DISEASES inferred ¹⁴ ¹⁴
29	RNU4ATAC	RNA, U4atac Small Nuclear	RNA Gene	9.34	DISEASES inferred ¹⁴ ¹⁴
30	MIR15A	MicroRNA 15a	RNA Gene	9.33	DISEASES inferred ¹⁴ ¹⁴
31	KDM4C	Lysine Demethylase 4C	Protein Coding	9.29	DISEASES inferred ¹⁴ ¹⁴
32	PRODH	Proline Dehydrogenase 1	Protein Coding	9.25	DISEASES inferred ¹⁴ ¹⁴
33	RHO	Rhodopsin	Protein Coding	9.24	DISEASES inferred ¹⁴
34	MIR214	MicroRNA 214	RNA Gene	9.13	DISEASES inferred ¹⁴ ¹⁴
35	MIR335	MicroRNA 335	RNA Gene	9.08	DISEASES inferred ¹⁴ ¹⁴
36	MIR675	MicroRNA 675	RNA Gene	9.02	DISEASES inferred ¹⁴ ¹⁴
37	MIR361	MicroRNA 361	RNA Gene	8.96	DISEASES inferred ¹⁴ ¹⁴
38	MIRLET7A1	MicroRNA Let-7a-1	RNA Gene	8.95	DISEASES inferred ¹⁴ ¹⁴
39	MIR96	MicroRNA 96	RNA Gene	8.95	DISEASES inferred ¹⁴ ¹⁴
40	RPE65	Retinoid Isomerohydrolase RPE65	Protein Coding	8.94	DISEASES inferred ¹⁴
41	MIR221	MicroRNA 221	RNA Gene	8.84	DISEASES inferred ¹⁴ ¹⁴
42	TP53	Tumor Protein P53	Protein Coding	8.81	DISEASES inferred ¹⁴
43	MIR106B	MicroRNA 106b	RNA Gene	8.8	DISEASES inferred ¹⁴ ¹⁴
44	MIR93	MicroRNA 93	RNA Gene	8.78	DISEASES inferred ¹⁴ ¹⁴
45	GJB2	Gap Junction Protein Beta 2	Protein Coding	8.77	DISEASES inferred ¹⁴
46	MIR144	MicroRNA 144	RNA Gene	8.77	DISEASES inferred ¹⁴ ¹⁴
47	MIRLET7B	MicroRNA Let-7b	RNA Gene	8.71	DISEASES inferred ¹⁴ ¹⁴
48	MIR132	MicroRNA 132	RNA Gene	8.7	DISEASES inferred ¹⁴ ¹⁴
49	TNF	Tumor Necrosis Factor	Protein Coding	8.67	DISEASES inferred ¹⁴
50	MIR29A	MicroRNA 29a	RNA Gene	8.67	DISEASES inferred ¹⁴ ¹⁴

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Variations for Sensory System Disease

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Expression for Sensory System Disease

Search GEO for disease gene expression data for Sensory System Disease.

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Pathways for Sensory System Disease

Pathways related to Sensory System Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	miRNAs involved in DNA damage response ⁷⁴	11.16	MIR21 MIR20A MIR17
2	Cell differentiation - expanded index ⁷⁴ Show member pathways Cell differentiation - index ⁷⁴	11.15	MIR9-1 MIR20A MIR199A1 MIR17
3	miRNAs involvement in the immune response in sepsis ⁷⁴	10.72	MIR9-1 MIR21 MIR199A1 MIR126

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GO Terms for Sensory System Disease

Cellular components related to Sensory System Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.93	SERPINA3 MIR21 MIR20A MIR204 MIR199A1 MIR17
2	RISC complex	GO:0016442	9.58	MIR9-1 MIR21 MIR20A MIR204 MIR199A1 MIR17
3	extracellular vesicle	GO:1903561	9.35	MIR34A MIR21 MIR20A MIR17 MIR126

Biological processes related to Sensory System Disease according to GeneCards Suite gene sharing:

(show all 19)

#	Name	GO ID	Score	Top Affiliating Genes
1	miRNA-mediated gene silencing	GO:0035195	10.09	MIR126 MIR140 MIR142 MIR17 MIR199A1 MIR204
2	positive regulation of angiogenesis	GO:0045766	9.88	MIR21 MIR20A MIR199A1 MIR126
3	negative regulation of gene expression	GO:0010629	9.87	MIR9-1 MIR34A MIR21 MIR20A MIR199A1 MIR17
4	cellular response to hypoxia	GO:0071456	9.85	MIR34A MIR17 MIR140 MIR126
5	negative regulation of cell migration	GO:0030336	9.8	MIR9-1 MIR34A MIR21 MIR204 MIR126
6	negative regulation of inflammatory response	GO:0050728	9.77	MIR126 MIR142 MIR199A1 MIR204 MIR20A
7	positive regulation of vascular associated smooth muscle cell proliferation	GO:1904707	9.74	MIR21 MIR20A MIR17
8	negative regulation of NIK/NF-kappaB signaling	GO:1901223	9.7	MIR9-1 MIR21 MIR204
9	negative regulation of cardiac muscle cell apoptotic process	GO:0010667	9.67	MIR21 MIR20A MIR199A1
10	negative regulation of sprouting angiogenesis	GO:1903671	9.63	MIR34A MIR20A MIR17
11	negative regulation of vascular associated smooth muscle cell migration	GO:1904753	9.61	MIR34A MIR21 MIR140
12	positive regulation of connective tissue replacement	GO:1905205	9.58	MIR34A MIR199A1
13	negative regulation of vascular associated smooth muscle cell apoptotic process	GO:1905460	9.56	MIR21 MIR17
14	positive regulation of metalloendopeptidase activity	GO:1904685	9.54	MIR21 MIR17
15	negative regulation of BMP secretion	GO:2001285	9.51	MIR17 MIR140
16	positive regulation of pulmonary blood vessel remodeling	GO:1905111	9.48	MIR20A MIR17
17	positive regulation of cardiac muscle hypertrophy in response to stress	GO:1903244	9.43	MIR20A MIR199A1 MIR17
18	miRNA-mediated gene silencing by inhibition of translation	GO:0035278	9.43	MIR9-1 MIR21 MIR20A MIR204 MIR17 MIR126
19	negative regulation of vascular endothelial growth factor production	GO:1904046	9.02	MIR34A MIR20A MIR199A1 MIR17 MIR140

Molecular functions related to Sensory System Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA 3'-UTR binding	GO:0003730	9.65	MIR9-1 MIR34A MIR21 MIR20A MIR204 MIR199A1
2	mRNA base-pairing translational repressor activity	GO:1903231	9.32	MIR9-1 MIR34A MIR21 MIR20A MIR204 MIR199A1

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Sources for Sensory System Disease

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: SNS026 MIFTS: 25	Sensory System Disease Categories: Neuronal diseases, Smell/Taste diseases	Data Licensing For inquiries, contact: [email protected]
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