Sensory System Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SNS026 MIFTS: 22	Sensory System Disease Categories: Neuronal diseases, Smell/Taste diseases
Genes Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Sensory System Disease

MalaCards integrated aliases for Sensory System Disease:

Name: Sensory System Disease ¹² ¹⁵ ¹⁷

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Smell/Taste diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050155

EFO ¹⁷ EFO_0001058

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Summaries for Sensory System Disease

Disease Ontology : ¹² A nervous system disease which is located in a part of the nervous system responsible for processing sensory information that consists of sensory receptors, neural pathways, and parts of the brain involved in sensory perception. Commonly recognized sensory systems are those for vision, hearing, somatic sensation (touch), taste and olfaction (smell).

MalaCards based summary : Sensory System Disease is related to auditory system disease and leber congenital amaurosis with early-onset deafness. An important gene associated with Sensory System Disease is CRYAA (Crystallin Alpha A), and among its related pathways/superpathways is MicroRNAs in cancer.

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Related Diseases for Sensory System Disease

Diseases related to Sensory System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 325)

#	Related Disease	Score	Top Affiliating Genes
1	auditory system disease	32.4	SERPINA3 MIR96 ERCC6 EPRS1
2	leber congenital amaurosis with early-onset deafness	11.0
3	muscle tissue disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR199A1 MIR142 MIR126
4	eye degenerative disease	10.7	VEGFA U2AF1 SERPINA3 PRODH MIR17 KDM4C
5	uveal disease	10.7	VEGFA U2AF1 SERPINA3 MIR9-1 MIR199A1 MIR142
6	x-linked recessive disease	10.7	U2AF1 SERPINA3 PRODH MIR142 ICOSLG H2AC18
7	autoimmune disease of musculoskeletal system	10.7	SERPINA3 MIR21 MIR199A1 MIR17 MIR142 MIR126
8	x-linked monogenic disease	10.7	U2AF1 SERPINA3 PRODH MIR9-1 MIR142 ICOSLG
9	pancreas disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
10	autoimmune disease of the nervous system	10.7	U2AF1 SERPINA3 PRODH MIR9-1 MIR142 MIR126
11	autoimmune disease of central nervous system	10.7	U2AF1 SERPINA3 PRODH MIR9-1 MIR142 MIR126
12	upper respiratory tract disease	10.7	SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17 MIR142
13	gastrointestinal system benign neoplasm	10.7	SERPINA3 MIR21 MIR199A1 MIR17 MIR142 H2AC18
14	stomach disease	10.7	SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17 MIR142
15	muscular disease	10.7	U2AF1 SERPINA3 PRODH MIR9-1 MIR21 MIR199A1
16	female reproductive system disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
17	immune deficiency disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
18	overnutrition	10.7	SERPINA3 PRODH MIR21 MIR199A1 MIR17 MIR142
19	central nervous system disease	10.7	U2AF1 SERPINA3 PRODH MIR9-1 MIR21 MIR199A1
20	bone inflammation disease	10.7	VEGFA SERPINA3 MIR21 MIR199A1 MIR17 MIR142
21	intestinal benign neoplasm	10.7	VEGFA SERPINA3 MIR21 MIR199A1 MIR17 MIR142
22	uterine anomalies	10.7	U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
23	nervous system disease	10.7	VEGFA U2AF1 SERPINA3 PRODH MIR96 MIR9-1
24	skin disease	10.7	VEGFA U2AF1 SERPINA3 PRODH MIR9-1 MIR21
25	ovary epithelial cancer	10.7	VEGFA U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1
26	arteries, anomalies of	10.7	VEGFA SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
27	eye disease	10.7	VEGFA U2AF1 SERPINA3 PRODH MIR9-1 MIR21
28	autosomal genetic disease	10.7	VEGFA U2AF1 SERPINA3 PRODH MIR9-1 MIR21
29	respiratory system cancer	10.7	U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
30	reproductive system disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
31	contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a	10.7	VEGFA U2AF1 SERPINA3 PRODH MIR9-1 MIR21
32	malignant ovarian surface epithelial-stromal neoplasm	10.7	VEGFA SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
33	disease by infectious agent	10.7	SERPINA3 PRODH MIR9-1 MIR21 MIR199A1 MIR17
34	peripheral nervous system disease	10.7	VEGFA U2AF1 SERPINA3 PRODH MIR9-1 MIR21
35	leukocyte disease	10.7	VEGFA U2AF1 SERPINA3 MIR21 MIR199A1 MIR17
36	bladder disease	10.7	U2AF1 MIR96 MIR9-1 MIR21 MIR199A1 MIR17
37	bile duct disease	10.7	SERPINA3 MIR9-1 MIR199A1 MIR17 MIR142 KDM4C
38	chromosomal duplication syndrome	10.7	U2AF1 SERPINA3 PRODH MIR9-1 MIR126 KDM4C
39	urinary system disease	10.7	U2AF1 SERPINA3 PRODH MIR9-1 MIR21 MIR199A1
40	colonic disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
41	mature b-cell neoplasm	10.7	U2AF1 MIR9-1 MIR199A1 MIR17 MIR142 MIR126
42	glucose metabolism disease	10.7	VEGFA SERPINA3 PRODH MIR9-1 MIR21 MIR199A1
43	inherited metabolic disorder	10.7	SERPINA3 PRODH MIR9-1 MIR21 MIR199A1 MIR17
44	autosomal recessive disease	10.7	U2AF1 SERPINA3 PRODH ICOSLG H2AC18 ERCC6
45	chromosomal disease	10.7	U2AF1 SERPINA3 PRODH MIR9-1 MIR21 MIR17
46	endocrine system disease	10.7	U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
47	connective tissue disease	10.7	VEGFA U2AF1 SERPINA3 PRODH MIR9-1 MIR21
48	endocrine gland cancer	10.7	SERPINA3 MIR96 MIR9-1 MIR21 MIR199A1 MIR17
49	connective tissue cancer	10.7	VEGFA U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1
50	cervix disease	10.7	MIR9-1 MIR21 MIR199A1 MIR17 MIR142 MIR126

Graphical network of the top 20 diseases related to Sensory System Disease:

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Symptoms & Phenotypes for Sensory System Disease

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Drugs & Therapeutics for Sensory System Disease

Search Clinical Trials , NIH Clinical Center for Sensory System Disease

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Genetic Tests for Sensory System Disease

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Anatomical Context for Sensory System Disease

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Publications for Sensory System Disease

Articles related to Sensory System Disease:

#	Title	Authors	PMID	Year
1	X-linked infantile periodic alternating nystagmus. ⁶¹	Hertle RW...Seward A	16020310	2005

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Genes for Sensory System Disease

Genes related to Sensory System Disease (0 elite genes):

(show top 50) (show all 112)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CRYAA	Crystallin Alpha A	Protein Coding	14.42	DISEASES inferred ¹⁵ ¹⁵
2	H2AC18	H2A Clustered Histone 18	Protein Coding	12.7	DISEASES inferred ¹⁵ ¹⁵
3	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	11.38	DISEASES inferred ¹⁵ ¹⁵
4	ERCC6	ERCC Excision Repair 6, Chromatin Remodeling Factor	Protein Coding	11.23	DISEASES inferred ¹⁵ ¹⁵
5	CFHR2	Complement Factor H Related 2	Protein Coding	10.9	DISEASES inferred ¹⁵ ¹⁵
6	SERPINA3	Serpin Family A Member 3	Protein Coding	10.79	DISEASES inferred ¹⁵ ¹⁵
7	U2AF1	U2 Small Nuclear RNA Auxiliary Factor 1	Protein Coding	10.62	DISEASES inferred ¹⁵ ¹⁵
8	MIR17	MicroRNA 17	RNA Gene	10.56	DISEASES inferred ¹⁵ ¹⁵
9	MIR21	MicroRNA 21	RNA Gene	10.5	DISEASES inferred ¹⁵ ¹⁵
10	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	10.06	DISEASES inferred ¹⁵ ¹⁵
11	MIR199A1	MicroRNA 199a-1	RNA Gene	10.03	DISEASES inferred ¹⁵ ¹⁵
12	MIR126	MicroRNA 126	RNA Gene	9.82	DISEASES inferred ¹⁵ ¹⁵
13	MIR9-1	MicroRNA 9-1	RNA Gene	9.82	DISEASES inferred ¹⁵ ¹⁵
14	MIR96	MicroRNA 96	RNA Gene	9.77	DISEASES inferred ¹⁵ ¹⁵
15	EPRS1	Glutamyl-Prolyl-TRNA Synthetase 1	Protein Coding	9.7	DISEASES inferred ¹⁵ ¹⁵
16	PRODH	Proline Dehydrogenase 1	Protein Coding	9.59	DISEASES inferred ¹⁵ ¹⁵
17	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	9.53	DISEASES inferred ¹⁵
18	APC	APC Regulator Of WNT Signaling Pathway	Protein Coding	9.48	DISEASES inferred ¹⁵ ¹⁵
19	MIR142	MicroRNA 142	RNA Gene	9.47	DISEASES inferred ¹⁵ ¹⁵
20	KDM4C	Lysine Demethylase 4C	Protein Coding	9.47	DISEASES inferred ¹⁵ ¹⁵
21	MIR204	MicroRNA 204	RNA Gene	9.45	DISEASES inferred ¹⁵ ¹⁵
22	RHO	Rhodopsin	Protein Coding	9.37	DISEASES inferred ¹⁵
23	MIR15A	MicroRNA 15a	RNA Gene	9.36	DISEASES inferred ¹⁵ ¹⁵
24	MIR125A	MicroRNA 125a	RNA Gene	9.36	DISEASES inferred ¹⁵ ¹⁵
25	RNU4ATAC	RNA, U4atac Small Nuclear (U12-Dependent Splicing)	RNA Gene	9.35	DISEASES inferred ¹⁵ ¹⁵
26	MIR20A	MicroRNA 20a	RNA Gene	9.24	DISEASES inferred ¹⁵ ¹⁵
27	MIRLET7B	MicroRNA Let-7b	RNA Gene	9.19	DISEASES inferred ¹⁵ ¹⁵
28	MIR675	MicroRNA 675	RNA Gene	9.06	DISEASES inferred ¹⁵ ¹⁵
29	RPE65	Retinoid Isomerohydrolase RPE65	Protein Coding	8.97	DISEASES inferred ¹⁵
30	MIR214	MicroRNA 214	RNA Gene	8.95	DISEASES inferred ¹⁵ ¹⁵
31	GJB2	Gap Junction Protein Beta 2	Protein Coding	8.94	DISEASES inferred ¹⁵
32	TP53	Tumor Protein P53	Protein Coding	8.87	DISEASES inferred ¹⁵
33	MIR27A	MicroRNA 27a	RNA Gene	8.84	DISEASES inferred ¹⁵ ¹⁵
34	MIR181A1	MicroRNA 181a-1	RNA Gene	8.83	DISEASES inferred ¹⁵ ¹⁵
35	MIR30A	MicroRNA 30a	RNA Gene	8.83	DISEASES inferred ¹⁵ ¹⁵
36	MIR335	MicroRNA 335	RNA Gene	8.82	DISEASES inferred ¹⁵ ¹⁵
37	MIR140	MicroRNA 140	RNA Gene	8.81	DISEASES inferred ¹⁵ ¹⁵
38	TNF	Tumor Necrosis Factor	Protein Coding	8.78	DISEASES inferred ¹⁵
39	MYOC	Myocilin	Protein Coding	8.77	DISEASES inferred ¹⁵
40	CDK4	Cyclin Dependent Kinase 4	Protein Coding	8.77	DISEASES inferred ¹⁵
41	MIR361	MicroRNA 361	RNA Gene	8.75	DISEASES inferred ¹⁵ ¹⁵
42	CFH	Complement Factor H	Protein Coding	8.74	DISEASES inferred ¹⁵
43	MIR223	MicroRNA 223	RNA Gene	8.72	DISEASES inferred ¹⁵ ¹⁵
44	ABCA4	ATP Binding Cassette Subfamily A Member 4	Protein Coding	8.7	DISEASES inferred ¹⁵
45	ALB	Albumin	Protein Coding	8.69	DISEASES inferred ¹⁵
46	MIR144	MicroRNA 144	RNA Gene	8.68	DISEASES inferred ¹⁵ ¹⁵
47	MIR146B	MicroRNA 146b	RNA Gene	8.67	DISEASES inferred ¹⁵ ¹⁵
48	CD4	CD4 Molecule	Protein Coding	8.67	DISEASES inferred ¹⁵
49	IL6	Interleukin 6	Protein Coding	8.67	DISEASES inferred ¹⁵
50	MIR27B	MicroRNA 27b	RNA Gene	8.67	DISEASES inferred ¹⁵ ¹⁵

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Variations for Sensory System Disease

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Expression for Sensory System Disease

Search GEO for disease gene expression data for Sensory System Disease.

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Pathways for Sensory System Disease

Pathways related to Sensory System Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	MicroRNAs in cancer ³⁶	11.72	VEGFA MIR96 MIR9-1 MIR21 MIR199A1 MIR17

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GO Terms for Sensory System Disease

Biological processes related to Sensory System Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.65	VEGFA MIR21 MIR126
2	positive regulation of protein kinase B signaling	GO:0051897	9.62	VEGFA MIR21 MIR199A1 MIR126
3	positive regulation of endothelial cell migration	GO:0010595	9.58	VEGFA MIR21 MIR199A1
4	positive regulation of angiogenesis	GO:0045766	9.56	VEGFA MIR21 MIR199A1 MIR126
5	positive regulation of cardiac muscle hypertrophy in response to stress	GO:1903244	9.46	MIR199A1 MIR17
6	miRNA mediated inhibition of translation	GO:0035278	9.46	MIR17 MIR21 MIR9-1 MIR96
7	positive regulation of metalloendopeptidase activity	GO:1904685	9.43	MIR21 MIR17
8	negative regulation of vascular associated smooth muscle cell apoptotic process	GO:1905460	9.37	MIR21 MIR17
9	gene silencing by miRNA	GO:0035195	9.17	MIR126 MIR142 MIR17 MIR199A1 MIR21 MIR9-1
10	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	GO:1903589	9.13	MIR126 MIR21 VEGFA

Molecular functions related to Sensory System Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA 3'-UTR binding	GO:0003730	9.35	MIR9-1 MIR21 MIR17 MIR142 MIR126
2	mRNA binding involved in posttranscriptional gene silencing	GO:1903231	9.17	MIR126 MIR142 MIR17 MIR199A1 MIR21 MIR9-1

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Sources for Sensory System Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia