MCID: SNS026
MIFTS: 25

Sensory System Disease

Categories: Neuronal diseases, Smell/Taste diseases
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Aliases & Classifications for Sensory System Disease

MalaCards integrated aliases for Sensory System Disease:

Name: Sensory System Disease 11 14 16

Classifications:



External Ids:

Disease Ontology 11 DOID:0050155

Summaries for Sensory System Disease

Disease Ontology: 11 A nervous system disease which is located in a part of the nervous system responsible for processing sensory information that consists of sensory receptors, neural pathways, and parts of the brain involved in sensory perception. Commonly recognized sensory systems are those for vision, hearing, somatic sensation (touch), taste and olfaction (smell).

MalaCards based summary: Sensory System Disease is related to leber congenital amaurosis with early-onset deafness and auditory system disease. An important gene associated with Sensory System Disease is CRYAA (Crystallin Alpha A), and among its related pathways/superpathways are miRNAs involved in DNA damage response and Cell differentiation - expanded index. Affiliated tissues include brain.

Related Diseases for Sensory System Disease

Diseases related to Sensory System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 404)
# Related Disease Score Top Affiliating Genes
1 leber congenital amaurosis with early-onset deafness 11.0
2 auditory system disease 11.0
3 nervous system disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
4 connective tissue disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
5 eye disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
6 retinal disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR21 MIR20A MIR204
7 myopathy 10.7 U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR142
8 chromosomal disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
9 muscular disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
10 central nervous system disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
11 peripheral nervous system disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR199A1
12 muscle tissue disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR142
13 physical disorder 10.7 U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
14 urinary system disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
15 disease of mental health 10.7 U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
16 leukocyte disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR17
17 uveal disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR199A1 MIR17 MIR142
18 leukemia, acute myeloid 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR204
19 respiratory system disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
20 skin disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
21 reproductive system disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
22 eye degenerative disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR17 MIR142 MIR140
23 endocrine system disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
24 immune system disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
25 bladder disease 10.7 U2AF1 MIR9-1 MIR34A MIR21 MIR204 MIR199A1
26 female reproductive system disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
27 inherited metabolic disorder 10.7 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A MIR204
28 integumentary system disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
29 malignant ovarian surface epithelial-stromal neoplasm 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR199A1
30 glucose metabolism disease 10.7 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A MIR204
31 carbohydrate metabolic disorder 10.7 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A MIR204
32 amyotrophic lateral sclerosis 1 10.7 U2AF1 SERPINA3 MIR9-1 MIR199A1 MIR17 MIR142
33 male reproductive organ cancer 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
34 breast disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
35 pancreas disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
36 connective tissue cancer 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
37 head and neck cancer 10.7 U2AF1 MIR9-1 MIR34A MIR21 MIR20A MIR204
38 spinal disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
39 lung cancer 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
40 respiratory system cancer 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
41 arteries, anomalies of 10.7 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A MIR204
42 cervix carcinoma 10.7 U2AF1 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR142
43 leukemia, chronic lymphocytic 10.7 U2AF1 MIR9-1 MIR34A MIR21 MIR20A MIR199A1
44 immune deficiency disease 10.7 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A MIR199A1
45 autoimmune disease of central nervous system 10.7 SERPINA3 MIR9-1 MIR21 MIR199A1 MIR142 MIR140
46 gastrointestinal system disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
47 lymphatic system disease 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR20A
48 biliary tract disease 10.7 SERPINA3 MIR9-1 MIR21 MIR204 MIR199A1 MIR17
49 peripheral nervous system neoplasm 10.7 U2AF1 SERPINA3 MIR9-1 MIR34A MIR21 MIR199A1
50 bile duct adenocarcinoma 10.7 SERPINA3 MIR9-1 MIR21 MIR204 MIR199A1 MIR17

Graphical network of the top 20 diseases related to Sensory System Disease:



Diseases related to Sensory System Disease

Symptoms & Phenotypes for Sensory System Disease

Drugs & Therapeutics for Sensory System Disease

Search Clinical Trials, NIH Clinical Center for Sensory System Disease

Genetic Tests for Sensory System Disease

Anatomical Context for Sensory System Disease

Organs/tissues related to Sensory System Disease:

MalaCards : Brain

Publications for Sensory System Disease

Articles related to Sensory System Disease:

# Title Authors PMID Year
1
X-linked infantile periodic alternating nystagmus. 62
16020310 2005

Variations for Sensory System Disease

Expression for Sensory System Disease

Search GEO for disease gene expression data for Sensory System Disease.

Pathways for Sensory System Disease

Pathways related to Sensory System Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.16 MIR21 MIR20A MIR17
2
Show member pathways
11.15 MIR9-1 MIR20A MIR199A1 MIR17
3 10.72 MIR9-1 MIR21 MIR199A1 MIR126

GO Terms for Sensory System Disease

Cellular components related to Sensory System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.93 SERPINA3 MIR21 MIR20A MIR204 MIR199A1 MIR17
2 RISC complex GO:0016442 9.58 MIR9-1 MIR21 MIR20A MIR204 MIR199A1 MIR17
3 extracellular vesicle GO:1903561 9.35 MIR34A MIR21 MIR20A MIR17 MIR126

Biological processes related to Sensory System Disease according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 miRNA-mediated gene silencing GO:0035195 10.09 MIR126 MIR140 MIR142 MIR17 MIR199A1 MIR204
2 positive regulation of angiogenesis GO:0045766 9.88 MIR21 MIR20A MIR199A1 MIR126
3 negative regulation of gene expression GO:0010629 9.87 MIR9-1 MIR34A MIR21 MIR20A MIR199A1 MIR17
4 cellular response to hypoxia GO:0071456 9.85 MIR34A MIR17 MIR140 MIR126
5 negative regulation of cell migration GO:0030336 9.8 MIR9-1 MIR34A MIR21 MIR204 MIR126
6 negative regulation of inflammatory response GO:0050728 9.77 MIR126 MIR142 MIR199A1 MIR204 MIR20A
7 positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 9.74 MIR21 MIR20A MIR17
8 negative regulation of NIK/NF-kappaB signaling GO:1901223 9.7 MIR9-1 MIR21 MIR204
9 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.67 MIR21 MIR20A MIR199A1
10 negative regulation of sprouting angiogenesis GO:1903671 9.63 MIR34A MIR20A MIR17
11 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.61 MIR34A MIR21 MIR140
12 positive regulation of connective tissue replacement GO:1905205 9.58 MIR34A MIR199A1
13 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.56 MIR21 MIR17
14 positive regulation of metalloendopeptidase activity GO:1904685 9.54 MIR21 MIR17
15 negative regulation of BMP secretion GO:2001285 9.51 MIR17 MIR140
16 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.48 MIR20A MIR17
17 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.43 MIR20A MIR199A1 MIR17
18 miRNA-mediated gene silencing by inhibition of translation GO:0035278 9.43 MIR9-1 MIR21 MIR20A MIR204 MIR17 MIR126
19 negative regulation of vascular endothelial growth factor production GO:1904046 9.02 MIR34A MIR20A MIR199A1 MIR17 MIR140

Molecular functions related to Sensory System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.65 MIR9-1 MIR34A MIR21 MIR20A MIR204 MIR199A1
2 mRNA base-pairing translational repressor activity GO:1903231 9.32 MIR9-1 MIR34A MIR21 MIR20A MIR204 MIR199A1

Sources for Sensory System Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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