Separation Anxiety Disorder disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ An anxiety disorder that involves the feeling of excessive and inappropriate levels of anxiety over being separated from a person to whom the individual has a strong emotional attachment or place.

MalaCards based summary: Separation Anxiety Disorder, also known as separation anxiety disorder of childhood, is related to anxiety and panic disorder. An important gene associated with Separation Anxiety Disorder is EPRS1 (Glutamyl-Prolyl-TRNA Synthetase 1), and among its related pathways/superpathways are Sudden infant death syndrome (SIDS) susceptibility pathways and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The drugs Vilazodone Hydrochloride and Serotonin Receptor Agonists have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and cortex, and related phenotypes are nervous system and behavior/neurological

Wikipedia: ⁷⁵ Separation anxiety disorder (SAD) is an anxiety disorder in which an individual experiences excessive... more...

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Related Diseases for Separation Anxiety Disorder

Diseases related to Separation Anxiety Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)

#	Related Disease	Score	Top Affiliating Genes
1	anxiety	30.4	TSPO SLC6A4 OXTR OXT MAOA HTR1A
2	panic disorder	30.3	TSPO SLC6A4 MAOA HTR1A DRD4 CRH
3	acute stress disorder	30.2	SLC6A4 OXT CRH BDNF
4	agoraphobia	30.1	SLC6A4 MAOA HTR1A CTU2 CRH COMT
5	bulimia nervosa	30.0	SLC6A4 OXT MAOA DRD4 COMT BDNF
6	tic disorder	29.9	SLC6A4 MAOA HTR1A DRD4 COMT
7	personality disorder	29.8	SLC6A4 OXTR MAOA HTR1A DRD4 CRH
8	social phobia	29.7	SLC6A4 OXTR OXT MAOA HTR1A CTU2
9	post-traumatic stress disorder	29.7	SLC6A4 OXTR OXT MAOA HTR1A CRH
10	dissociative disorder	29.7	SLC6A4 OXT OSTF1 COMT BDNF
11	antisocial personality disorder	29.7	SLC6A4 OXTR OXT MAOA DRD4 COMT
12	mood disorder	29.6	SLC6A4 OXT MAOA HTR1A DRD4 CRH
13	alcohol use disorder	29.6	SLC6A4 MAOA DRD4 CRH COMT BDNF
14	oppositional defiant disorder	29.6	SLC6A4 OXTR OXT OSTF1 MAOA DRD4
15	phobia, specific	29.5	SLC6A4 OXT OSTF1 MAOA HTR1A CTU2
16	eating disorder	29.4	SLC6A4 OXTR OXT HTR1A CRH COMT
17	anorexia nervosa	29.3	SLC6A4 OXT MAOA HTR1A DRD4 CRH
18	alcohol dependence	29.2	TSPO SLC6A4 MAOA HTR1A DRD4 CRH
19	obsessive-compulsive disorder	29.2	SLC6A4 OXTR OXT MAOA HTR1A DRD4
20	major depressive disorder	29.2	TSPO SLC6A4 OXT OSTF1 MAOA HTR1A
21	bipolar disorder	29.2	TSPO SLC6A4 MAOA HTR1A DRD4 CRH
22	generalized anxiety disorder	29.2	TSPO SLC6A4 OXT OSTF1 MAOA HTR1A
23	disease of mental health	28.9	SLC6A4 OXTR OXT MAOA HTR1A EPRS1
24	autism	28.8	TSPO SLC6A4 OXTR OXT MAOA HTR1A
25	autism spectrum disorder	28.8	TSPO SLC6A4 OXTR OXT MAOA HTR1A
26	attention deficit-hyperactivity disorder	27.8	SLC6A4 PLEKHB2 OXTR OXT OSTF1 MAOA
27	adult syndrome	10.3
28	animal phobia	10.3	SLC6A4 OXT
29	severe combined immunodeficiency	10.3
30	cascade stomach	10.3	SLC6A4 HTR1A
31	hypoactive sexual desire disorder	10.3	OXT HTR1A
32	voyeurism	10.3	OXT MAOA
33	pyromania	10.3	SLC6A4 MAOA
34	vagus nerve disease	10.3	HTR1A CRH
35	hyperphenylalaninemia, bh4-deficient, a	10.2
36	dependent personality disorder	10.2
37	obsessive-compulsive personality disorder	10.2	SLC6A4 COMT
38	kluver-bucy syndrome	10.2	SLC6A4 OXT CRH
39	somatization disorder	10.2	SLC6A4 OXT CRH
40	drug psychosis	10.2	HTR1A COMT
41	drug-induced mental disorder	10.2	HTR1A COMT
42	infantile liver failure syndrome	10.2	NBAS EPRS1
43	avoidant personality disorder	10.2	SLC6A4 MAOA DRD4
44	body dysmorphic disorder	10.2	SLC6A4 OXT MAOA
45	atypical autism	10.2	OXTR OXT
46	dissociative amnesia	10.2	CRH BDNF
47	migraine without aura	10.2	SLC6A4 HTR1A DRD4
48	multiple personality disorder	10.2	OXT OSTF1
49	chronic pain	10.2	COMT BDNF
50	conversion disorder	10.2	COMT BDNF

Graphical network of the top 20 diseases related to Separation Anxiety Disorder:

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Symptoms & Phenotypes for Separation Anxiety Disorder

MGI Mouse Phenotypes related to Separation Anxiety Disorder:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	9.7	BDNF COMT CRH DLGAP2 DRD4 HTR1A
2	behavior/neurological	MP:0005386	9.4	BDNF COMT CRH DLGAP2 DRD4 HTR1A

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Drugs & Therapeutics for Separation Anxiety Disorder

Drugs for Separation Anxiety Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Vilazodone Hydrochloride

Phase 4

163521-08-2

2

Serotonin Receptor Agonists

Phase 4

3

Serotonin 5-HT1 Receptor Agonists

Phase 4

4

Guanfacine

Approved, Investigational

Phase 2

29110-47-2

3519

5

Adrenergic alpha-Agonists

Phase 2

6

Adrenergic Agonists

Phase 2

7

Adrenergic Agents

Phase 2

8

Antihypertensive Agents

Phase 2

9

Sertraline

Approved

79617-96-2

68617

10

Neurotransmitter Agents

11

Psychotropic Drugs

12

Antidepressive Agents

13

Serotonin Uptake Inhibitors

14

Serotonin

Investigational, Nutraceutical

50-67-9

5202

Interventional clinical trials:

(show all 27)

#	Name	Status	NCT ID	Phase	Drugs
1	Vilazodone for Separation Anxiety Disorder	Completed	NCT01999920	Phase 4	Vilazodone;Placebo
2	Utilizing Health Information Technology to Improve Health Care Quality: Implementation of a Computerized Cognitive Behavioral Therapy Protocol for Childhood Anxiety	Completed	NCT01416805	Phase 3
3	Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders	Completed	NCT01178385	Phase 2, Phase 3
4	A Phase 2, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Assess the Safety and Tolerability of SPD503 in Subjects Aged 6-17 Years With Generalized Anxiety Disorder (GAD), Separation Anxiety Disorder (SAD), or Social Phobia (SoP).	Completed	NCT01470469	Phase 2	SPD503 (extended-release Guanfacine hydrochloride);Placebo
5	Effectiveness of Group and Individual Treatment of Childhood Anxiety Disorders in Community Clinics. A Randomized Controlled Trial.	Completed	NCT00735995	Phase 2
6	A Brief Behavioral Treatment for Anxiety in Young Children	Completed	NCT02051192	Phase 1, Phase 2
7	Effects of Parental Behavior on Child Anxiety Regulation	Completed	NCT00593515	Phase 2
8	Assessment and Treatment - Anxiety in Children and Adults (Child Part)	Completed	NCT00586586	Phase 2
9	A Randomized, Controlled Trial of Modular CBT for Child Anxiety Disorders in Elementary School Settings	Completed	NCT00569829	Phase 2
10	Feasible Delivery of CBT for Rural Latino Youth With Anxiety	Completed	NCT01491880	Phase 1, Phase 2
11	Combination of Active or Placebo Attentional Bias Modification Treatment (ABMT) to Either Cognitive Behavioral Group Therapy (CBGT) or Psychoeducational Control Intervention (PCI) for Anxiety Disorders in Children: a Randomized Clinical Trial	Unknown status	NCT01687764
12	Psychological Treatment of Separation Anxiety Disorder	Completed	NCT00255112
13	Sleep, Mood, and Behavior Study:Transdisciplinary Studies of CBT for Anxiety in Youth	Completed	NCT00787397
14	Transdisciplinary Studies of CBT for Anxiety in Youth	Completed	NCT00774150
15	2/3 Treatment of Anxiety in Autism Spectrum Disorder	Completed	NCT02028247
16	Exposure-Focused Family-Based CBT for Youth With ASD and Comorbid Anxiety	Completed	NCT01919970
17	Dimensional Brain Behavior Predictors of CBT Outcomes in Pediatric Anxiety	Completed	NCT02810171
18	Decision-Making Processes and Brain Function in Anxiety-Disordered and Non-Anxious Youth	Completed	NCT00104195
19	Cognitive Behavioral Therapy for Anxiety Disorders in Adolescents With Autism	Completed	NCT01563003
20	Brain Markers of Anxiety Disorders and SSRI/CBT Treatment in Children and Adolescents	Completed	NCT01160588		Sertraline
21	Computer- Assisted Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders	Completed	NCT01565629
22	Building an Outcomes Assessment Infrastructure to Assess Youth in the McLean Anxiety Mastery Program at McLean Hospital	Recruiting	NCT02305537
23	Brain Response Associated With Parent-based Treatment for Childhood Anxiety Disorders	Recruiting	NCT03585010
24	Web-based Attention Bias Modification Treatment for Childhood Anxiety Disorders: a Randomized, Double-blind, Controlled Trial	Terminated	NCT03764644
25	Attention Bias Modification Treatment for Anxious Youth	Terminated	NCT01979263
26	Acoustic Neuromodulation (ANM) for Youth With Anxiety Disorders: A Pilot Study	Terminated	NCT02572973
27	Treatment of Pediatric Anxiety Disorders by Predicting Treatment Response Through Biocellular Markers and Sleep	Terminated	NCT02189213		Sertraline

Search NIH Clinical Center for Separation Anxiety Disorder

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Genetic Tests for Separation Anxiety Disorder

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Anatomical Context for Separation Anxiety Disorder

Organs/tissues related to Separation Anxiety Disorder:

MalaCards : Brain, Prefrontal Cortex, Cortex, Eye, Heart, Skin

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Publications for Separation Anxiety Disorder

Articles related to Separation Anxiety Disorder:

(show top 50) (show all 651)

#	Title	Authors	PMID	Year
1	Anxiety disorders, depression and incontinence in preschool children-A population-based study. ⁶²	Hussong J...von Gontard A	35979705	2022
2	Prevalence and Phenomenology of Anxiety in Preschool-Aged Children with Autism Spectrum Disorder. ⁶²	Chan N...Neece CL	36048376	2022
3	Prenatal exposure to a natural disaster and early development of psychiatric disorders during the preschool years: stress in pregnancy study. ⁶²	Nomura Y...Hurd YL	36129196	2022
4	Pre-existing Mental Health Diagnoses Are Associated With Higher Rates of Postoperative Complications, Readmissions, and Reoperations Following Arthroscopic Rotator Cuff Repair. ⁶²	Freshman RD...Lansdown DA	35970453	2022
5	Reliability and validity of the DSM-5 Diagnostic Interview Schedule for Children, Adolescents, and Parents-5 in externalizing disorders and common comorbidities. ⁶²	Tissue AD...Dadds MR	35038264	2022
6	Relationship of behavioral inhibition to separation anxiety in a sample (N = 377) of adult individuals with mood and anxiety disorders. ⁶²	Pini S...Milrod B	35569286	2022
7	Factor structure of the Chinese version of the Screen for Adult Anxiety Related Disorders (SCARRED). ⁶²	Wang S...Wang Z	35580532	2022
8	Psychiatric comorbidity associated with weight status in 9 to 10 year old children. ⁶²	Smith KE...Mason TB	35048539	2022
9	Do Children of Patients with Bipolar Disorder have a Worse Perception of Sleep Quality? ⁶²	Estrada-Jaramillo S...Palacio-Ortiz JD	35210211	2022
10	COVID-19-Related Stigma and Mental Health of Children and Adolescents During Pandemic. ⁶²	Ozbaran B...Ozhan MH	34878913	2022
11	Mental disorders and their comorbidities among children and adolescents aged 6 to 18 years in Lorestan Province. ⁶²	Nazari H...Beyranvand S	35222656	2022
12	Prevalence of Psychiatric Disorders among Children and Adolescents: A Study from Khuzestan. ⁶²	Riahi F...Hooshyari Z	36204445	2022
13	Do Metacognitions of Children and Adolescents with Anxiety Disorders Change after Intensified Exposure Therapy? ⁶²	Kocher LM...Christiansen H	35204889	2022
14	Prediction of anxiety disorders using a feature ensemble based bayesian neural network. ⁶²	Xiong H...McLellan LF	34628061	2021
15	Separation Anxiety Disorder. ⁶²	Patel AK...Bryant B	34751707	2021
16	Relationship Between Adult Separation Anxiety and Attachment Styles and Vaginismus. ⁶²	Unlubilgin E...Tekin OM	34417127	2021
17	Pediatric anxiety associated with altered facial emotion recognition. ⁶²	Rappaport LM...Hettema JM	34146888	2021
18	EEG correlates of attentional control in anxiety disorders: A systematic review of error-related negativity and correct-response negativity findings. ⁶²	Michael JA...Hoy KE	34038831	2021
19	What Event-Related Potential Tells Us about Brain Function: Child-Adolescent Psychiatric Perspectives. ⁶²	Kim JS...Shim SH	34285633	2021
20	Neighborhood characteristics and psychiatric disorders in the aftermath of mass trauma: A representative study of New York City public school 4th-12th graders after 9/11. ⁶²	Musa GJ...Hoven CW	33992981	2021
21	[Separation anxiety disorder]. ⁶²	Schiele MA...Domschke K	33319254	2021
22	Liraglutide combined with intense lifestyle modification in the management of obesity in adolescents. ⁶²	Apperley LJ...Senniappan S	33823101	2021
23	Are anxiety disorders a pathway to obsessive-compulsive disorder? Different trajectories of OCD and the role of death anxiety. ⁶²	Menzies RE...Dar-Nimrod I	32921190	2021
24	Separation Anxiety and Measures of Suicide Risk Among Patients With Mood and Anxiety Disorders. ⁶²	Pini S...Domschke K	33989461	2021
25	Separation anxiety disorder among outpatients with major depressive disorder: Prevalence and clinical correlates. ⁶²	Elbay RY...Avci SH	33378709	2021
26	The Children's Revised Impact of Event Scale: Dimensionality and Measurement Invariance in a Sample of Children and Adolescents Exposed to Wildfires. ⁶²	Pereira J...Rijo D	33245801	2021
27	Portuguese validation of the Adult Separation Anxiety-Questionnaire (ASA-27). ⁶²	Ruiz-Garcia A...Fenollar-Cortes J	33690669	2021
28	Separation Anxiety-An Unseen Cause for Development of Abnormal Oral and Paraoral Habits and Malocclusion: A Review of Literature and Report of Two Cases. ⁶²	Dhote VS...Dhote AV	35645476	2021
29	Separation Anxiety Disorder in Panic Disorder Patients with and without Comorbid Agoraphobia. ⁶²	Dogan B...Sevincok L	33577430	2021
30	[Clinical variants and types of course of separation anxiety disorder in adults]. ⁶²	Arkusha IA...Avedisova AS	34184473	2021
31	The Role of Social Media Use in Peer Bullying Victimization and Onset of Anxiety Among Indonesian Elementary School Children. ⁶²	Kaloeti DVS...Bidzan M	33995192	2021
32	Personalized Assessment of Anxiety and Avoidance in Children and Their Parents-Development and Evaluation of the Anxiety and Avoidance Scale for Children. ⁶²	Lippert MW...Schneider S	34867587	2021
33	Psychiatric comorbidity of developmental trauma disorder and posttraumatic Stress disorder: findings from the DTD field trial replication (DTDFT-R). ⁶²	Ford JD...van der Kolk B	34249242	2021
34	Association Between Family Structure and Anxiety Disorder Among Pre-schoolers: A Cross-Sectional Study in Urban Chongqing, China. ⁶²	Hu H...Zhao X	34721092	2021
35	Psychometrics of the Spanish Version of the Screen for Adult Anxiety Related Disorders (SCAARED). ⁶²	Sanchez-Cueva S...Alcantud-Marin F	33643088	2021
36	Prevalence, Comorbidity and Predictor of Separation Anxiety Disorder in Children and Adolescents. ⁶²	Mohammadi MR...Zandifar A	32418141	2020
37	Psychometric Properties of the SCARED in a Nationally Representative U.S. Sample of 5-12-Year-Olds. ⁶²	Sequeira SL...Lindhiem O	31136197	2020
38	Psychometric Evaluation of the Child and Parent Versions of the Coping Questionnaire. ⁶²	Crane ME...Kendall PC	32157488	2020
39	Clinical reappraisal of the Composite International Diagnostic Interview Version 3.0 in the Saudi National Mental Health Survey. ⁶²	Kessler RC...Altwaijri YA	33245606	2020
40	The relationship between separation anxiety and intolerance of uncertainty in pregnant women. ⁶²	Sevil Degirmenci S...Aksaray G	30585096	2020
41	Gaze-Contingent Music Reward Therapy for Clinically Anxious 7- to 10-Year-Olds: An Open Multiple Baseline Feasibility Study. ⁶²	Linetzky M...Bar-Haim Y	30908085	2020
42	Do Children of Patients with Bipolar Disorder have a Worse Perception of Sleep Quality? ⁶²	Estrada-Jaramillo S...Palacio-Ortiz JD	33735036	2020
43	Internet-delivered cognitive behavior therapy with minimal therapist support for anxious children and adolescents: predictors of response. ⁶²	Spence SH...Donovan CL	32424896	2020
44	Childhood and adolescent mental health of NICU graduates: an observational study. ⁶²	Chiorean A...Van Lieshout RJ	31974300	2020
45	Accuracy of the Diagnostic Infant and Preschool Assessment (DIPA) in a Dutch sample. ⁶²	Gigengack MR...Lindauer RJL	32360141	2020
46	eMental Health Literacy and Knowledge of Common Child Mental Health Disorders among Parents of Preschoolers. ⁶²	Cormier E...Schluck G	32400237	2020
47	The Diagnostic Infant Preschool Assessment-Likert Version: Preparation, Concurrent Construct Validation, and Test-Retest Reliability. ⁶²	Scheeringa MS	32159386	2020
48	Adult Separation Anxiety Disorder Symptomology as a Risk Factor for Thin-Ideal Internalization: The Role of Self-Concept Clarity. ⁶²	Posavac SS...Posavac HD	30744502	2020
49	Adult separation anxiety disorder: The human-animal bond. ⁶²	Dowsett E...Chur-Hansen A	32339110	2020
50	Separation Anxiety Symptom Profiles and Parental Accommodation Across Pediatric Anxiety Disorders. ⁶²	Phillips KE...Kendall PC	31907734	2020

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Genes for Separation Anxiety Disorder

Genes related to Separation Anxiety Disorder (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	EPRS1	Glutamyl-Prolyl-TRNA Synthetase 1	Protein Coding	6.26	DISEASES inferred ¹⁴
2	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	6.23	DISEASES inferred ¹⁴
3	OXT	Oxytocin/Neurophysin I Prepropeptide	Protein Coding	5.96	DISEASES inferred ¹⁴
4	DRD4	Dopamine Receptor D4	Protein Coding	5.83	DISEASES inferred ¹⁴
5	TSPO	Translocator Protein	Protein Coding	5.6	DISEASES inferred ¹⁴
6	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	5.47	DISEASES inferred ¹⁴
7	CRH	Corticotropin Releasing Hormone	Protein Coding	5.29	DISEASES inferred ¹⁴
8	MAOA	Monoamine Oxidase A	Protein Coding	5.29	DISEASES inferred ¹⁴
9	COMT	Catechol-O-Methyltransferase	Protein Coding	5.18	DISEASES inferred ¹⁴
10	OXTR	Oxytocin Receptor	Protein Coding	5.09	DISEASES inferred ¹⁴
11	NBAS	NBAS Subunit Of NRZ Tethering Complex	Protein Coding	5.05	DISEASES inferred ¹⁴
12	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	5.04	DISEASES inferred ¹⁴
13	CTU2	Cytosolic Thiouridylase Subunit 2	Protein Coding	5.02	DISEASES inferred ¹⁴
14	OSTF1	Osteoclast Stimulating Factor 1	Protein Coding	5.01	DISEASES inferred ¹⁴
15	ZNF74	Zinc Finger Protein 74	Protein Coding	4.97	DISEASES inferred ¹⁴
16	DLGAP2	DLG Associated Protein 2	Protein Coding	4.94	DISEASES inferred ¹⁴
17	DSCAS	DSC1/DSC2 Antisense RNA	RNA Gene	4.91	DISEASES inferred ¹⁴
18	TOR3A	Torsin Family 3 Member A	Protein Coding	4.71	DISEASES inferred ¹⁴
19	PLEKHB2	Pleckstrin Homology Domain Containing B2	Protein Coding	4.7	DISEASES inferred ¹⁴

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Variations for Separation Anxiety Disorder

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Expression for Separation Anxiety Disorder

Search GEO for disease gene expression data for Separation Anxiety Disorder.

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Pathways for Separation Anxiety Disorder

Pathways related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	11.76	SLC6A4 MAOA HTR1A BDNF
2	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics ⁶⁰	10.78	SLC6A4 MAOA HTR1A
3	Tyrosine metabolism p.1 (dopamine) ²²	10.69	MAOA COMT
4	Neurotransmitter clearance ⁶⁶ Show member pathways Dopamine clearance from the synaptic cleft ⁶⁶ Enzymatic degradation of dopamine by COMT ⁶⁶ Enzymatic degradation of Dopamine by monoamine oxidase ⁶⁶ Flavan-3-ol metabolic pathway ⁷⁴ Metabolism of serotonin ⁶⁶ Serotonin clearance from the synaptic cleft ⁶⁶	10.53	SLC6A4 MAOA COMT
5	Dopamine metabolism ⁷⁴	10.52	MAOA COMT
6	Vasopressin-like receptors ⁶⁶ Show member pathways Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) ⁶⁶ Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ⁶⁶	10.41	OXTR OXT
7	Methylphenidate Pathway, Pharmacodynamics ⁶⁰ Show member pathways Dopamine receptors ⁶⁶	10.38	SLC6A4 MAOA HTR1A DRD4 COMT
8	dopamine degradation ⁶¹	10.02	MAOA COMT

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GO Terms for Separation Anxiety Disorder

Biological processes related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

(show all 18)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of synapse assembly	GO:0051965	10	OXTR OXT BDNF
2	maternal behavior	GO:0042711	9.88	OXTR OXT
3	synaptic transmission, dopaminergic	GO:0001963	9.87	DRD4 CRH
4	sleep	GO:0030431	9.86	OXTR OXT
5	memory	GO:0007613	9.86	BDNF OXT OXTR SLC6A4
6	regulation of dopamine metabolic process	GO:0042053	9.85	HTR1A DRD4
7	response to progesterone	GO:0032570	9.85	TSPO OXTR OXT
8	dopamine catabolic process	GO:0042420	9.81	MAOA COMT
9	positive regulation of uterine smooth muscle contraction	GO:0070474	9.8	OXTR OXT
10	response to amphetamine	GO:0001975	9.8	OXTR OXT DRD4
11	neurotransmitter catabolic process	GO:0042135	9.78	MAOA COMT
12	positive regulation of penile erection	GO:0060406	9.76	OXT OXTR
13	negative regulation of gastric acid secretion	GO:0060455	9.73	OXT OXTR
14	positive regulation of norepinephrine secretion	GO:0010701	9.71	OXTR OXT
15	social behavior	GO:0035176	9.56	SLC6A4 OXTR OXT DRD4
16	catecholamine metabolic process	GO:0006584	9.54	MAOA COMT
17	regulation of digestive system process	GO:0044058	9.16	OXTR OXT
18	sperm ejaculation	GO:0042713	9.1	SLC6A4 OXTR OXT

Molecular functions related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serotonin binding	GO:0051378	8.92	SLC6A4 HTR1A

Sources

Sources for Separation Anxiety Disorder

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: SPR012 MIFTS: 40	Separation Anxiety Disorder Categories: Mental diseases	Data Licensing For inquiries, contact: [email protected]
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