MCID: SPR012
MIFTS: 41

Separation Anxiety Disorder

Categories: Mental diseases

Aliases & Classifications for Separation Anxiety Disorder

MalaCards integrated aliases for Separation Anxiety Disorder:

Name: Separation Anxiety Disorder 12 73 15 17 70
Separation Anxiety Disorder of Childhood 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:10685
ICD10 32 F93.0
UMLS 70 C0003477 C1527281

Summaries for Separation Anxiety Disorder

Disease Ontology : 12 An anxiety disorder that involves the feeling of excessive and inappropriate levels of anxiety over being separated from a person to whom the individual has a strong emotional attachment or place.

MalaCards based summary : Separation Anxiety Disorder, also known as separation anxiety disorder of childhood, is related to dependent personality disorder and depression. An important gene associated with Separation Anxiety Disorder is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Transmission across Chemical Synapses and Serotonergic synapse. The drugs Neurotransmitter Agents and Antidepressive Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and cortex, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 73 Separation anxiety disorder (SAD) is an anxiety disorder in which an individual experiences excessive... more...

Related Diseases for Separation Anxiety Disorder

Diseases related to Separation Anxiety Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 dependent personality disorder 30.8 MAOA DRD4
2 depression 30.7 SLC6A4 MAOA HTR1A
3 agoraphobia 30.4 SLC6A4 MAOA HTR1A CTU2 COMT
4 acute stress disorder 30.4 SLC6A4 OXT HTR1A
5 panic disorder 30.3 TSPO SLC6A4 SLC6A3 MAOA HTR1A DRD4
6 social phobia 30.2 SLC6A4 OXT MAOA HTR1A CTU2 COMT
7 post-traumatic stress disorder 30.0 SLC6A4 OXTR MAOA COMT
8 generalized anxiety disorder 30.0 TSPO SLC6A4 SLC6A3 MAOA HTR1A COMT
9 mood disorder 29.9 SLC6A4 SLC6A3 MAOA HTR1A DRD4 COMT
10 tic disorder 29.8 SLC6A4 SLC6A3 MAOA DRD4 COMT
11 bulimia nervosa 29.7 SLC6A4 OXT MAOA DRD4 COMT
12 anxiety 29.7 TSPO SLC6A4 SLC6A3 OXTR OXT OPRM1
13 personality disorder 29.6 SLC6A4 SLC6A3 OXTR MAOA HTR1A DRD4
14 phobia, specific 29.6 SLC6A4 OXT MAOA HTR1A HM13 CTU2
15 oppositional defiant disorder 29.5 SLC6A4 SLC6A3 OXTR OXT MAOA DRD4
16 eating disorder 29.5 SLC6A4 SLC6A3 OXTR OPRM1 COMT
17 anorexia nervosa 29.5 SLC6A4 OXT MAOA HTR1A DRD4 COMT
18 bipolar disorder 29.3 TSPO SLC6A4 SLC6A3 MAOA HTR1A DRD4
19 mental depression 29.3 SLC6A4 SLC6A3 OXTR OXT MAOA HTR1A
20 major depressive disorder 29.1 SLC6A4 SLC6A3 OXTR OXT OPRM1 MAOA
21 antisocial personality disorder 29.0 SLC6A4 SLC6A3 OXTR OXT MAOA DRD4
22 obsessive-compulsive disorder 29.0 SLC6A4 SLC6A3 OXTR OXT MAOA HTR1A
23 attention deficit-hyperactivity disorder 28.9 TSPO SLC6A4 SLC6A3 OXT OPRM1 MAOA
24 autism spectrum disorder 28.5 SLC6A4 SLC6A3 OXTR OXT OPRM1 MAOA
25 autism 27.6 SLC6A4 SLC6A3 OXTR OXT OPRM1 MAOA
26 disease of mental health 27.3 TSPO SLC6A4 SLC6A3 OXTR OXT OPRM1
27 barbiturate dependence 10.3 SLC6A4 OPRM1
28 alcoholic psychosis 10.3 SLC6A4 SLC6A3
29 animal phobia 10.3 SLC6A4 OXT
30 amphetamine abuse 10.3 SLC6A4 SLC6A3
31 severe combined immunodeficiency 10.3
32 exhibitionism 10.3 MAOA DRD4
33 barbiturate abuse 10.3 OPRM1 MAOA
34 narcissistic personality disorder 10.3 OXT MAOA
35 dissociative disorder 10.3 SLC6A4 OXT
36 hypoactive sexual desire disorder 10.3 OXT HTR1A
37 pedophilia 10.3 OXT MAOA
38 corneal dystrophy, lisch epithelial 10.2 MAOA HTR1A
39 retrograde amnesia 10.2 SLC6A4 HTR1A
40 anterograde amnesia 10.2 TSPO HTR1A
41 tardive dyskinesia 10.2 DRD4 COMT
42 delusional disorder 10.2 SLC6A3 HTR1A DRD4
43 drug dependence 10.2 SLC6A4 SLC6A3 OPRM1
44 cocaine abuse 10.2 TSPO SLC6A4 SLC6A3
45 migraine without aura 10.2 SLC6A4 HTR1A DRD4
46 obsessive-compulsive personality disorder 10.2 SLC6A4 COMT
47 chronic pain 10.2 OPRM1 COMT
48 psychosexual disorder 10.2 SLC6A4 OXT HTR1A
49 sexual disorder 10.2 SLC6A4 OXT HTR1A
50 motion sickness 10.2 OPRM1 HTR1A

Graphical network of the top 20 diseases related to Separation Anxiety Disorder:



Diseases related to Separation Anxiety Disorder

Symptoms & Phenotypes for Separation Anxiety Disorder

MGI Mouse Phenotypes related to Separation Anxiety Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 COMT DLGAP2 DRD4 GTF2I HTR1A MAOA
2 cardiovascular system MP:0005385 9.91 COMT GTF2I HM13 HTR1A MAOA NBAS
3 endocrine/exocrine gland MP:0005379 9.81 COMT GTF2I HM13 OPRM1 OXT OXTR
4 homeostasis/metabolism MP:0005376 9.73 COMT DRD4 HM13 HTR1A LRCH2 MAOA
5 nervous system MP:0003631 9.44 COMT DLGAP2 DRD4 GTF2I HM13 HTR1A

Drugs & Therapeutics for Separation Anxiety Disorder

Drugs for Separation Anxiety Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Neurotransmitter Agents Phase 4
2 Antidepressive Agents Phase 4
3 Psychotropic Drugs Phase 4
4 Vilazodone Hydrochloride Phase 4 163521-08-2
5 Serotonin Receptor Agonists Phase 4
6 Serotonin 5-HT1 Receptor Agonists Phase 4
7 Serotonin Uptake Inhibitors Phase 4
8
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
9
Guanfacine Approved, Investigational Phase 2 29110-47-2 3519
10 Adrenergic alpha-Agonists Phase 2
11 Adrenergic Agents Phase 2
12 Adrenergic Agonists Phase 2
13 Antihypertensive Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vilazodone for Separation Anxiety Disorder Completed NCT01999920 Phase 4 Vilazodone;Placebo
2 A Randomized, Controlled Trial of Modular CBT for Child Anxiety Disorders in Elementary School Settings Completed NCT00569829 Phase 2
3 Effects of Parental Behavior on Child Anxiety Regulation Completed NCT00593515 Phase 2
4 Assessment and Treatment - Anxiety in Children and Adults (Child Part) Completed NCT00586586 Phase 2
5 Effectiveness of Group and Individual Treatment of Childhood Anxiety Disorders in Community Clinics. A Randomized Controlled Trial. Completed NCT00735995 Phase 2
6 A Phase 2, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Assess the Safety and Tolerability of SPD503 in Subjects Aged 6-17 Years With Generalized Anxiety Disorder (GAD), Separation Anxiety Disorder (SAD), or Social Phobia (SoP). Completed NCT01470469 Phase 2 SPD503 (extended-release Guanfacine hydrochloride);Placebo
7 Psychological Treatment of Separation Anxiety Disorder Completed NCT00255112
8 Acoustic Neuromodulation (ANM) for Youth With Anxiety Disorders: A Pilot Study Terminated NCT02572973

Search NIH Clinical Center for Separation Anxiety Disorder

Genetic Tests for Separation Anxiety Disorder

Anatomical Context for Separation Anxiety Disorder

MalaCards organs/tissues related to Separation Anxiety Disorder:

40
Brain, Eye, Cortex, Heart, Skin, Prefrontal Cortex

Publications for Separation Anxiety Disorder

Articles related to Separation Anxiety Disorder:

(show top 50) (show all 623)
# Title Authors PMID Year
1
Are anxiety disorders a pathway to obsessive-compulsive disorder? Different trajectories of OCD and the role of death anxiety. 61
32921190 2021
2
Separation Anxiety Disorder in Panic Disorder Patients with and without Comorbid Agoraphobia. 61
33577430 2021
3
Separation anxiety disorder among outpatients with major depressive disorder: Prevalence and clinical correlates. 61
33378709 2021
4
The Children's Revised Impact of Event Scale: Dimensionality and Measurement Invariance in a Sample of Children and Adolescents Exposed to Wildfires. 61
33245801 2021
5
Psychometrics of the Spanish Version of the Screen for Adult Anxiety Related Disorders (SCAARED). 61
33643088 2021
6
Portuguese validation of the Adult Separation Anxiety-Questionnaire (ASA-27). 61
33690669 2021
7
Prevalence, Comorbidity and Predictor of Separation Anxiety Disorder in Children and Adolescents. 61
32418141 2020
8
[Separation anxiety disorder]. 61
33319254 2020
9
Psychometric Properties of the SCARED in a Nationally Representative U.S. Sample of 5-12-Year-Olds. 61
31136197 2020
10
Psychometric Evaluation of the Child and Parent Versions of the Coping Questionnaire. 61
32157488 2020
11
Gaze-Contingent Music Reward Therapy for Clinically Anxious 7- to 10-Year-Olds: An Open Multiple Baseline Feasibility Study. 61
30908085 2020
12
The relationship between separation anxiety and intolerance of uncertainty in pregnant women. 61
30585096 2020
13
Clinical reappraisal of the Composite International Diagnostic Interview Version 3.0 in the Saudi National Mental Health Survey. 61
33245606 2020
14
Internet-delivered cognitive behavior therapy with minimal therapist support for anxious children and adolescents: predictors of response. 61
32424896 2020
15
Do Children of Patients with Bipolar Disorder have a Worse Perception of Sleep Quality? 61
33735036 2020
16
Childhood and adolescent mental health of NICU graduates: an observational study. 61
31974300 2020
17
Accuracy of the Diagnostic Infant and Preschool Assessment (DIPA) in a Dutch sample. 61
32360141 2020
18
The Diagnostic Infant Preschool Assessment-Likert Version: Preparation, Concurrent Construct Validation, and Test-Retest Reliability. 61
32159386 2020
19
eMental Health Literacy and Knowledge of Common Child Mental Health Disorders among Parents of Preschoolers. 61
32400237 2020
20
Adult separation anxiety disorder: The human-animal bond. 61
32339110 2020
21
Adult Separation Anxiety Disorder Symptomology as a Risk Factor for Thin-Ideal Internalization: The Role of Self-Concept Clarity. 61
30744502 2020
22
Separation Anxiety Symptom Profiles and Parental Accommodation Across Pediatric Anxiety Disorders. 61
31907734 2020
23
Associations between family factors, childhood adversity, negative life events and child anxiety disorders: an exploratory study of diagnostic specificity. 61
31727188 2020
24
Separation anxiety in PTSD: A pilot study of mechanisms in patients undergoing IPT. 61
32097526 2020
25
A neurobiological framework of separation anxiety and related phenotypes. 61
32046934 2020
26
The Mental Health of Young Canadian Mothers. 61
32057608 2020
27
Lifetime prevalence, sociodemographic predictors, and comorbidities of oppositional defiant disorder: the National Epidemiology of Iranian Child and Adolescent Psychiatric disorders (IRCAP). 61
31433003 2020
28
Anxiety disorders comorbidity in pediatric bipolar disorder: a meta-analysis and meta-regression study. 61
31899546 2020
29
Editorial: Parent-Based Treatment for Childhood Anxiety. 61
31128270 2020
30
Systematic Review and Meta-Analysis of Anxiety and Depression in Youth With Epilepsy. 61
31904859 2020
31
When to Raise Our White Flag-A Discussion of Scope of Practice in a Resource Scarce World. 61
31917736 2020
32
Emotional and Behavioral Disorders in Pediatric Cancer Patients. 61
32021635 2020
33
Development of a Computerized Adaptive Test for Separation Anxiety Disorder Among Adolescents. 61
32625130 2020
34
Anxiety Disorders in the DSM-5: Changes, Controversies, and Future Directions. 61
32002930 2020
35
The Role of the Oxytocin System in Anxiety Disorders. 61
32002925 2020
36
The Impact of Treatment Expectations on Exposure Process and Treatment Outcome in Childhood Anxiety Disorders. 61
31313062 2020
37
[Prevalence of anxiety separation disorder in adult outpatients with non-psychotic mental disorders]. 61
32678554 2020
38
Subthreshold Autism Spectrum in a Patient with Anorexia Nervosa and Behçet's Syndrome. 61
32607270 2020
39
"I feel good when I drink"-detecting childhood-onset alcohol abuse and dependence in a Ugandan community trial cohort. 61
33110445 2020
40
Evaluation of neuropsychiatric comorbidities and their clinical characteristics in Chinese children with asthma using the MINI kid tool. 61
31752780 2019
41
Anxiety and Fear-Related Disorders in the ICD-11: Results from a Global Case-controlled Field Study. 61
32018071 2019
42
Anxiety disorders anticipate the diagnosis of bipolar disorder in comorbid patients: Findings from an Italian tertiary clinic. 61
31302527 2019
43
Body Mass Index Status across Different Psychiatric Disorders in a National Survey amongst Children and Adolescents: To Identify the Role of Gender. 61
32071598 2019
44
Psychopharmacology in Pediatric Mixed Anxiety Disorder: An Evidence-based Review. 61
32082949 2019
45
Psychopharmacology of Pediatric Anxiety Disorders: A Narrative Review. 61
31656713 2019
46
The utility of the SCAS-C/P to detect specific anxiety disorders among clinically anxious children. 61
31070449 2019
47
The characteristics of the comorbidity between social anxiety and separation anxiety disorders in adult patients. 61
31322453 2019
48
Emotional Awareness Predicts Specific Cognitive-Behavioral Therapy Outcomes for Anxious Youth. 61
30603936 2019
49
The 2014 Ontario Child Health Study Emotional Behavioural Scales (OCHS-EBS) Part I: A Checklist for Dimensional Measurement of Selected DSM-5 Disorders. 61
30376365 2019
50
An Analysis of the Child Behavior Checklist Anxiety Problems Scale's Predictive Capabilities. 61
31666760 2019

Variations for Separation Anxiety Disorder

Expression for Separation Anxiety Disorder

Search GEO for disease gene expression data for Separation Anxiety Disorder.

Pathways for Separation Anxiety Disorder

GO Terms for Separation Anxiety Disorder

Cellular components related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of presynaptic membrane GO:0099056 9.13 SLC6A4 SLC6A3 OPRM1
2 integral component of postsynaptic membrane GO:0099055 8.8 SLC6A4 SLC6A3 OPRM1

Biological processes related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.85 TSPO SLC6A4 SLC6A3 OXTR COMT
2 response to estradiol GO:0032355 9.81 SLC6A4 OXTR OXT
3 response to organic cyclic compound GO:0014070 9.8 SLC6A3 OXTR OXT COMT
4 female pregnancy GO:0007565 9.79 OXTR OXT COMT
5 memory GO:0007613 9.77 SLC6A4 OXTR OXT
6 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.74 OPRM1 HTR1A DRD4
7 response to progesterone GO:0032570 9.69 TSPO OXTR OXT
8 positive regulation of blood pressure GO:0045777 9.67 OXTR OXT
9 response to food GO:0032094 9.66 OXT OPRM1
10 negative regulation of nitric oxide biosynthetic process GO:0045019 9.66 TSPO OPRM1
11 response to pain GO:0048265 9.65 TSPO COMT
12 estrous cycle GO:0044849 9.65 OXTR OPRM1
13 vasoconstriction GO:0042310 9.65 SLC6A4 HTR1A
14 regulation of sensory perception of pain GO:0051930 9.65 OXT OPRM1 COMT
15 dopamine metabolic process GO:0042417 9.64 DRD4 COMT
16 negative regulation of cytosolic calcium ion concentration GO:0051481 9.63 OPRM1 GTF2I
17 neurotransmitter biosynthetic process GO:0042136 9.63 SLC6A4 SLC6A3
18 catecholamine metabolic process GO:0006584 9.62 MAOA COMT
19 social behavior GO:0035176 9.62 SLC6A4 OXTR OXT DRD4
20 maternal behavior GO:0042711 9.61 OXTR OXT
21 neurotransmitter catabolic process GO:0042135 9.61 MAOA COMT
22 response to amphetamine GO:0001975 9.61 OXTR OXT DRD4
23 sleep GO:0030431 9.6 OXTR OXT
24 monoamine transport GO:0015844 9.58 SLC6A4 SLC6A3
25 behavioral response to ethanol GO:0048149 9.58 OPRM1 DRD4
26 positive regulation of uterine smooth muscle contraction GO:0070474 9.56 OXTR OXT
27 negative regulation of gastric acid secretion GO:0060455 9.55 OXTR OXT
28 positive regulation of penile erection GO:0060406 9.54 OXTR OXT
29 eating behavior GO:0042755 9.54 OXTR OXT OPRM1
30 positive regulation of norepinephrine secretion GO:0010701 9.52 OXTR OXT
31 dopamine catabolic process GO:0042420 9.43 SLC6A3 MAOA COMT
32 regulation of digestive system process GO:0044058 9.4 OXTR OXT
33 regulation of dopamine metabolic process GO:0042053 9.33 SLC6A3 HTR1A DRD4
34 response to cocaine GO:0042220 9.26 SLC6A3 OXTR OXT OPRM1
35 sperm ejaculation GO:0042713 8.8 SLC6A4 OXTR OXT

Molecular functions related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter transporter activity GO:0005326 9.26 SLC6A4 SLC6A3
2 serotonin binding GO:0051378 9.16 SLC6A4 HTR1A
3 monoamine transmembrane transporter activity GO:0008504 8.96 SLC6A4 SLC6A3
4 dopamine binding GO:0035240 8.62 SLC6A3 DRD4

Sources for Separation Anxiety Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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