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MCID: SPR012
MIFTS: 40

Separation Anxiety Disorder

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Separation Anxiety Disorder

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MalaCards integrated aliases for Separation Anxiety Disorder:

Name: Separation Anxiety Disorder 12 76 15 73
Separation Anxiety Disorder of Childhood 73

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:10685
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Summaries for Separation Anxiety Disorder

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Disease Ontology : 12 An anxiety disorder that involves the feeling of excessive and inappropriate levels of anxiety over being separated from a person to whom the individual has a strong emotional attachment or place.

MalaCards based summary : Separation Anxiety Disorder, also known as separation anxiety disorder of childhood, is related to personality disorder and dependent personality disorder. An important gene associated with Separation Anxiety Disorder is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways is Peptide ligand-binding receptors. The drugs Dexmedetomidine and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Separation anxiety disorder (SAD), is an anxiety disorder in which an individual experiences excessive... more...

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Related Diseases for Separation Anxiety Disorder

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Diseases related to Separation Anxiety Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 personality disorder 30.2 DRD4 PRL SLC6A3
2 dependent personality disorder 30.0 DRD4 PIR
3 obsessive-compulsive disorder 29.6 DRD4 OXT OXTR PRL SLC6A3
4 autism 29.5 DRD4 HTR7 OXT OXTR SLC6A3
5 pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections 11.0
6 anxiety 10.8
7 panic disorder 10.3
8 phenytoin or carbamazepine toxicity 10.2 HLA-A HLA-B
9 histrionic personality disorder 10.2 OPRM1 PIR
10 conduct disorder 10.2 DRD4 OXTR SLC6A3
11 narcissistic personality disorder 10.2 OPRM1 PIR
12 postherpetic neuralgia 10.2 HLA-A HLA-B
13 delusional disorder 10.2 DRD4 HLA-A
14 atrial tachyarrhythmia with short pr interval 10.2 HLA-A HLA-B
15 substance dependence 10.2 DRD4 OPRM1 SLC6A3
16 withdrawal disorder 10.1 HTR7 OPRM1 TSPO
17 substance abuse 10.1 DRD4 PRL SLC6A3
18 phobic disorder 10.1 NBAS PIR
19 pars planitis 10.1 HLA-A HLA-B
20 pityriasis rosea 10.1 HLA-A HLA-B
21 alcohol dependence 10.1 DRD4 OPRM1 SLC6A3 TSPO
22 anterior uveitis 10.1 HLA-A HLA-B
23 social phobia 10.1
24 agoraphobia 10.1
25 pain agnosia 10.0 HTR7 OPRM1 OXT
26 agnosia 10.0 HTR7 OPRM1 OXT
27 psychotic disorder 10.0 DRD4 HLA-A PRL SLC6A3
28 postpartum depression 10.0 OXT OXTR PRL
29 chronic pyelonephritis 10.0 HLA-A HLA-B
30 dysthymic disorder 10.0 HTR7 PIR
31 generalized anxiety disorder 10.0
32 attention deficit-hyperactivity disorder 10.0 DRD4 OPRM1 OXT SLC6A3
33 pedophilia 9.9 OXT PRL RTN4
34 kleine-levin hibernation syndrome 9.9 CORT HTR7 SLC6A3
35 paraphilia disorder 9.9 OXT PRL RTN4
36 major depressive disorder 9.9 DRD4 OXT OXTR PRL SLC6A3
37 mental depression 9.8 CORT HTR7 OXT
38 phobia, specific 9.8
39 oppositional defiant disorder 9.8
40 autism spectrum disorder 9.8
41 mood disorder 9.8
42 schizophrenia 9.7 DRD4 HTR7 PRL RTN4 SLC6A3 TSPO
43 specific developmental disorder 9.7 DRD4 HTR7 OPRM1 OXT RTN4 SLC6A3
44 disease of mental health 9.6 DRD4 HTR7 OPRM1 OXT OXTR RTN4

Graphical network of the top 20 diseases related to Separation Anxiety Disorder:



Diseases related to Separation Anxiety Disorder
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Symptoms & Phenotypes for Separation Anxiety Disorder

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GenomeRNAi Phenotypes related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00240-S-1 10.07 CORT EPRS
2 Decreased viability GR00381-A-1 10.07 CORT RTN4
3 Decreased viability GR00381-A-2 10.07 CORT
4 Decreased viability GR00381-A-3 10.07 CORT
5 Decreased viability GR00402-S-2 10.07 CGAS CORT DRD4 EPRS GTF2I HLA-A
6 no effect GR00402-S-1 9.62 CGAS CORT DRD4 EPRS GTF2I HLA-A

MGI Mouse Phenotypes related to Separation Anxiety Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 CGAS CORT DRD4 GTF2I HTR7 OPRM1
2 endocrine/exocrine gland MP:0005379 9.91 CORT GTF2I OPRM1 OXT OXTR PRL
3 growth/size/body region MP:0005378 9.9 CORT EPRS GTF2I OPRM1 OXT OXTR
4 nervous system MP:0003631 9.73 DRD4 EPRS GTF2I HTR7 OPRM1 OXT
5 normal MP:0002873 9.23 CORT EPRS GTF2I OPRM1 OXTR RTN4
Sources

Drugs & Therapeutics for Separation Anxiety Disorder

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Drugs for Separation Anxiety Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 115)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 1,Phase 2,Early Phase 1 113775-47-6 68602 5311068
2
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 1 59467-70-8 4192
3
Ketamine Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 6740-88-1 3821
4
Guanfacine Approved, Investigational Phase 4,Phase 2 29110-47-2 3519
5 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
6 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
7 Antidepressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
8 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
9 Serotonin Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 Serotonin Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
12 Serotonin 5-HT1 Receptor Agonists Phase 4
13 Vilazodone Hydrochloride Phase 4 163521-08-2
14 Hypnotics and Sedatives Phase 4,Phase 2,Phase 1,Early Phase 1
15 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
16 Adrenergic Agonists Phase 4,Phase 2,Phase 1,Early Phase 1
17 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
18 Analgesics, Non-Narcotic Phase 4,Phase 1,Phase 2,Early Phase 1
19 Analgesics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
20 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2,Phase 1,Early Phase 1
21 Adrenergic alpha-Agonists Phase 4,Phase 2,Phase 1,Early Phase 1
22 Anti-Anxiety Agents Phase 4,Phase 3,Phase 2,Phase 1
23 Anesthetics Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1
24 GABA Modulators Phase 4,Phase 2,Phase 1
25 Adjuvants, Anesthesia Phase 4,Phase 2,Phase 1
26 GABA Agents Phase 4,Phase 2,Phase 1
27 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Anesthetics, Intravenous Phase 4,Phase 2,Phase 1,Not Applicable
29 Anesthetics, General Phase 4,Phase 2,Phase 1,Not Applicable
30 Anesthetics, Dissociative Phase 4,Phase 1,Phase 2,Not Applicable
31 Excitatory Amino Acid Antagonists Phase 4,Phase 1,Phase 2,Not Applicable
32 Excitatory Amino Acids Phase 4,Phase 1,Phase 2,Not Applicable
33 Antihypertensive Agents Phase 4,Phase 2,Not Applicable
34 Immunoglobulins, Intravenous Phase 4
35 gamma-Globulins Phase 4
36 Rho(D) Immune Globulin Phase 4
37 Immunologic Factors Phase 4
38 Antibodies Phase 4
39 Immunoglobulins Phase 4
40
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-67-9 5202
41
Histamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-45-6, 75614-87-8 774
42
Fluvoxamine Approved, Investigational Phase 3 54739-18-3 3404 5324346
43
Mirtazapine Approved Phase 3 61337-67-5, 85650-52-8 4205
44
Mianserin Approved, Investigational Phase 3 24219-97-4 4184
45
Ethanol Approved Phase 2, Phase 3 64-17-5 702
46
Methylphenidate Approved, Investigational Phase 2, Phase 3 113-45-1 4158
47
Dopamine Approved Phase 2, Phase 3,Phase 3 51-61-6, 62-31-7 681
48
Norepinephrine Approved Phase 3 51-41-2 439260
49
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
50
Polyestradiol phosphate Approved Phase 3 28014-46-2

Interventional clinical trials:

(show top 50) (show all 109)
# Name Status NCT ID Phase Drugs
1 Vilazodone for Separation Anxiety Disorder Completed NCT01999920 Phase 4 Vilazodone;Placebo
2 Dexmedetomidine Premedication in Children Completed NCT03174678 Phase 4 Dexmedetomidine
3 Oral Dexmedetomidine vs Midazoam For Premedication Completed NCT03357718 Phase 4 Precedex;Midazolam
4 Intranasal Dexmedetomidine vs Midazolam-ketamine Combination for Premedication of Pediatric Patients Completed NCT02072083 Phase 4 Dexmedetomidine;Ketamine
5 Ketamine Infusion for Adolescent Depression and Anxiety Active, not recruiting NCT02579928 Phase 4 Ketamine;Midazolam
6 A Study to Evaluate the Benefit of Octagam 5%® in Subjects With Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) Active, not recruiting NCT03348618 Phase 4
7 Guanfacine Extended Release and Mindfulness Skills Therapy Not yet recruiting NCT03258476 Phase 4 Guanfacine Extended Release;Placebo
8 Computerized Cognitive Behavioral Therapy for Childhood Anxiety in Community Health Centers Completed NCT01416805 Phase 3
9 Treatment for Anxiety in Children Completed NCT00000389 Phase 3 Fluvoxamine
10 Mirtazapine Treatment of Anxiety in Children and Adolescents With Pervasive Developmental Disorders Completed NCT01302964 Phase 3 Placebo;Mirtazapine
11 Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders Completed NCT01178385 Phase 2, Phase 3
12 A Study of Pediatric Patients With Attention Deficit/Hyperactivity Disorder Completed NCT00922636 Phase 2, Phase 3 LY2216684;Methylphenidate;Placebo (tablet);Placebo (capsule)
13 Effectiveness of Atomoxetine in Treating ADHD Symptoms in Children and Adolescents With Autism Completed NCT00498173 Phase 3 Atomoxetine;Placebo
14 A Study of Duloxetine in Adolescents With Juvenile Primary Fibromyalgia Syndrome Completed NCT01237587 Phase 3 Duloxetine;Placebo
15 Efficacy of Atomoxetine on Psychosocial Function of Children and Adolescents With Attention-Deficit/Hyperactivity Disorder (ADHD) Completed NCT00320528 Phase 3 atomoxetine
16 Primary Ovarian Insufficiency: Phenotype and Optimal Treatment Recruiting NCT03568708 Phase 3 Transdermal Estrogen
17 Psychotherapy for Anxiety in Children With Autism Spectrum Disorder Active, not recruiting NCT02028247 Phase 3
18 A Study of Pediatric Participants With Attention Deficit/Hyperactivity Disorder Terminated NCT00965419 Phase 2, Phase 3 Edivoxetine
19 Treatment Study for Rural Latino Youth With Anxiety Unknown status NCT01491880 Phase 1, Phase 2
20 Chronic Widespread Pain and White Blood Cell Activation Unknown status NCT02984397 Phase 1, Phase 2 Ketotifen Fumarate;Placebo
21 SPD503 in Subjects Aged 6-17 Years With Generalized Anxiety Disorder (GAD), Separation Anxiety Disorder (SAD), or Social Phobia (SoP) Completed NCT01470469 Phase 2 SPD503 (extended-release Guanfacine hydrochloride);Placebo
22 Modular Cognitive Behavioral Therapy for the Treatment of Child Anxiety Disorders in Elementary School Settings Completed NCT00569829 Phase 2
23 Effectiveness of Cognitive Behavioral Therapy (CBT) for Child Anxiety Disorders in Community Clinics in Norway Completed NCT00735995 Phase 2
24 Effects of Parental Behavior on Child Anxiety Regulation Completed NCT00593515 Phase 2
25 Effectiveness Study of CBT for Anxiety in Children Completed NCT00586586 Phase 2
26 A GameBoy as a Distraction Before Surgery in Children Completed NCT00176670 Phase 2 midazolam or GameBoy or parental presence
27 Brief Behavioral Treatment for Anxiety in Young Children Completed NCT02051192 Phase 1, Phase 2
28 Premedication With Nebulized Ketamine,Dexmedetomidine Versus Midazolam in Oncologic Preschool Children Completed NCT02935959 Phase 1, Phase 2 nebulized ketamine;nebulized Dexmedetomidine;nebulized midazolam
29 Antibiotic Treatment Trial for the PANDAS/PANS Phenotype Completed NCT01617083 Phase 2 Azithromycin;Placebo
30 Sequencing CBT for Child Anxiety: CBT Plus Sertraline Versus Switch to Sertraline Terminated NCT01977729 Phase 2 Sertraline
31 Cipralex® for Anxiety Disorders in Adolescents Unknown status NCT01293838 Phase 1 Cipralex®
32 Preventing Depression in the Children of Depressed African American Mothers Completed NCT00904917 Phase 1
33 Combination of Active or Placebo Attentional Bias Modification Treatment (ABMT) to Either Cognitive Behavioral Group Therapy (CBGT) or Psychoeducational Control Intervention (PCI) for Anxiety Disorders in Children Unknown status NCT01687764 Not Applicable
34 Comorbidity Between Balance and Childhood Anxiety Unknown status NCT00599742 Not Applicable
35 Effectiveness of Music Therapy Unknown status NCT01040611 Not Applicable
36 Assessing Different Methods of Anxiety Care in Pediatric Settings Unknown status NCT00769925 Not Applicable
37 TAFF-Psychological Treatment of Separation Anxiety Disorder Completed NCT00255112 Not Applicable
38 Brain Markers of Anxiety Disorders and SSRI/CBT Treatment in Children and Adolescents Completed NCT01160588 Sertraline
39 Internet-delivered Treatment for Children With Anxiety Disorders in a Rural Area; an Open Trial in a Clinical Setting Completed NCT02306356 Not Applicable
40 Transdisciplinary Studies of CBT for Anxiety in Youth: Child Anxiety Treatment Study Completed NCT00774150 Not Applicable
41 A Research Study of How Teens With and Without an Anxiety Disorder Make Decisions Completed NCT00104195
42 Internet-delivered Cognitive Behavior Therapy (CBT) for Children Age 8-12 Years With Anxiety Disorders Completed NCT01533402 Not Applicable
43 Sleep, Mood, and Behavior Study Completed NCT00787397 Not Applicable
44 Internet-Based CBT for Children With Anxiety Disorders: Implementation in Clinical Settings Completed NCT02350257 Not Applicable
45 Ventilatory Physiology in Children at Risk for Anxiety Completed NCT00101777
46 Reward-Related Processes and Brain Function Completed NCT00029588
47 Cartoon Distraction and Parental Presence on Anxiety in Pediatric Anesthesia Completed NCT02027844 Not Applicable
48 Attention Bias Modification Training for Child Anxiety CBT Nonresponders Completed NCT01819311 Not Applicable
49 The Effect of Preoperative Ketamine on the Emergence Characteristics in Children Undergoing Entropion Surgery Completed NCT02916407 Not Applicable Sevoflurane;Desflurane
50 Exposure-Focused Family-Based CBT for Youth With ASD and Comorbid Anxiety Completed NCT01919970 Not Applicable

Search NIH Clinical Center for Separation Anxiety Disorder

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Genetic Tests for Separation Anxiety Disorder

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Anatomical Context for Separation Anxiety Disorder

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MalaCards organs/tissues related to Separation Anxiety Disorder:

41
Brain, Testes, Eye, Lung, Tongue
Sources

Publications for Separation Anxiety Disorder

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Articles related to Separation Anxiety Disorder:

(show top 50) (show all 90)
# Title Authors Year
1
Interaction between the Opioid Receptor OPRM1 Gene and Mother-Child Language Style Matching Prospectively Predicts Children's Separation Anxiety Disorder Symptoms. ( 29576267 )
2018
2
Reappraising Preclinical Models of Separation Anxiety Disorder, Panic Disorder, and CO<sub>2</sub> Sensitivity: Implications for Methodology and Translation into New Treatments. ( 29696603 )
2018
3
Do Youth with Separation Anxiety Disorder Differ in Anxiety Sensitivity From Youth with Other Anxiety Disorders? ( 29666976 )
2018
4
Adult separation anxiety disorder in complicated grief: an exploratory study on frequency and correlates. ( 27683967 )
2017
5
A randomized controlled pilot trial of vilazodone for adult separation anxiety disorder. ( 29071764 )
2017
6
Why are we still missing adult separation anxiety disorder in clinical practice? ( 27343899 )
2016
7
Separation Anxiety Disorder in School-Age Children: What Health Care Providers Should Know. ( 28012800 )
2016
8
Can separation anxiety disorder escape its attachment to childhood? ( 27265693 )
2016
9
Associations of adult separation anxiety disorder with conflict-related trauma, ongoing adversity, and the psychosocial disruptions of mass conflict among West Papuan refugees. ( 26752442 )
2016
10
The separation of adult separation anxiety disorder. ( 27503572 )
2016
11
The DSM-5 Dimensional Anxiety Scales in a Dutch non-clinical sample: psychometric properties including the adult separation anxiety disorder scale. ( 27378317 )
2016
12
Psychopathology among parents of children and adolescents with separation anxiety disorder. ( 25605571 )
2015
13
Adult separation anxiety disorder: accepted but little understood. ( 25572307 )
2015
14
Dependent personality, separation anxiety disorder and other anxiety disorders in OCD. ( 26542617 )
2015
15
Pediatric-Onset and Adult-Onset Separation Anxiety Disorder Across Countries in the World Mental Health Survey. ( 26046337 )
2015
16
Separation anxiety disorder from the perspective of DSM-5: clinical investigation among subjects with panic disorder and associations with mood disorders spectrum. ( 25704393 )
2015
17
Separation anxiety disorder in adult patients with obsessive-compulsive disorder: Prevalence and clinical correlates. ( 24908152 )
2014
18
The relationships among separation anxiety disorder, adult attachment style and agoraphobia in patients with panic disorder. ( 25218272 )
2014
19
Early-life risk factors for panic and separation anxiety disorder: Insights and outstanding questions arising from human and animal studies of CO2 sensitivity. ( 24793177 )
2014
20
Biased attention to threat in paediatric anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, separation anxiety disorder) as a function of 'distress' versus 'fear' diagnostic categorization. ( 23591000 )
2014
21
The effective comparison between emotion-focused cognitive behavioral group therapy and cognitive behavioral group therapy in children with separation anxiety disorder. ( 24949029 )
2014
22
Separation anxiety disorder across the lifespan: DSM-5 lifts age restriction on diagnosis. ( 25453710 )
2014
23
The right amygdalar tumor presenting with symptoms of separation anxiety disorder (SAD): a case report. ( 24593853 )
2014
24
Patterns of family identification and self-congruence in childhood separation anxiety disorder. ( 23751201 )
2014
25
Responses to voluntary hyperventilation in children with separation anxiety disorder: implications for the link to panic disorder. ( 24064331 )
2013
26
Looking for balance between promoting adult separation anxiety disorder and overlooking it. ( 23901151 )
2013
27
Beliefs regarding child anxiety and parenting competence in parents of children with separation anxiety disorder. ( 22922077 )
2013
28
DSM-5 allows separation anxiety disorder to grow up. ( 23293308 )
2013
29
A randomized controlled trial of the child anxiety multi-day program (cAMP) for separation anxiety disorder. ( 23053618 )
2013
30
Separation anxiety disorder in adults: is the neglect real? ( 23382511 )
2013
31
Separation anxiety disorder: lumping or splitting? ( 23493754 )
2013
32
Adult separation anxiety disorder in DSM-5. ( 23673209 )
2013
33
Let's not abandon separation anxiety disorder in adulthood. ( 23901150 )
2013
34
Overlap of symptom domains of separation anxiety disorder in adulthood with panic disorder-agoraphobia. ( 23247205 )
2013
35
The Diagnostic Utility of Separation Anxiety Disorder Symptoms: An Item Response Theory Analysis. ( 23963543 )
2013
36
The efficacy of a family-based cognitive-behavioral treatment for separation anxiety disorder in children aged 8-13: a randomized comparison with a general anxiety program. ( 23607501 )
2013
37
Childhood separation anxiety disorder and adult onset panic attacks share a common genetic diathesis. ( 22461084 )
2012
38
The relationship between adult separation anxiety disorder and complicated grief in a cohort of 454 outpatients with mood and anxiety disorders. ( 22832169 )
2012
39
Does the vigilance-avoidance gazing behavior of children with separation anxiety disorder change after cognitive-behavioral therapy? ( 22466517 )
2012
40
Separation anxiety disorder increases among neonatal intensive care unit graduates. ( 21819341 )
2012
41
Hypersensitivity to 35% carbon dioxide in patients with adult separation anxiety disorder. ( 22542862 )
2012
42
Temperament and character dimensions of patients with adult separation anxiety disorder. ( 22440427 )
2012
43
Separation anxiety disorder in children: disorder-specific responses to experimental separation from the mother. ( 21923807 )
2012
44
Disorder-specific cognitive-behavioral therapy for separation anxiety disorder in young children: a randomized waiting-list-controlled trial. ( 21494062 )
2011
45
Separation anxiety disorder in OCD. ( 21308883 )
2011
46
Early predictors of separation anxiety disorder: early stranger anxiety, parental pathology and prenatal factors. ( 21847002 )
2011
47
Children suffering from separation anxiety disorder (SAD) show increased HPA axis activity compared to healthy controls. ( 20870248 )
2011
48
Brief report--associations of personality disorder with early separation anxiety in patients with adult separation anxiety disorder. ( 21309628 )
2011
49
Association of DRD4 polymorphism with severity of oppositional defiant disorder, separation anxiety disorder and repetitive behaviors in children with autism spectrum disorder. ( 20731709 )
2010
50
Vigilance and avoidance of threat in the eye movements of children with separation anxiety disorder. ( 19813086 )
2010
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Variations for Separation Anxiety Disorder

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Expression for Separation Anxiety Disorder

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Search GEO for disease gene expression data for Separation Anxiety Disorder.
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Pathways for Separation Anxiety Disorder

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Pathways related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Peptide ligand-binding receptors 66
Show member pathways
 12.49 CORT DRD4 HTR7 OPRM1 OXT OXTR
Sources

GO Terms for Separation Anxiety Disorder

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Cellular components related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.23 DRD4 HLA-A HLA-B HTR7 OPRM1 OXTR
2 MHC class I protein complex GO:0042612 8.96 HLA-A HLA-B

Biological processes related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.92 OXTR PRL SLC6A3 TSPO
2 response to ethanol GO:0045471 9.8 OPRM1 PRL SLC6A3
3 response to estradiol GO:0032355 9.79 OXT OXTR PRL
4 female pregnancy GO:0007565 9.78 OXT OXTR PRL
5 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.73 DRD4 HTR7 OPRM1
6 social behavior GO:0035176 9.7 DRD4 OXT OXTR
7 response to organic cyclic compound GO:0014070 9.67 OXT OXTR PRL SLC6A3
8 positive regulation of blood pressure GO:0045777 9.64 OXT OXTR
9 response to food GO:0032094 9.63 OPRM1 OXT
10 estrous cycle GO:0044849 9.61 OPRM1 OXTR
11 lactation GO:0007595 9.61 OXTR PRL SLC6A3
12 maternal behavior GO:0042711 9.6 OXT OXTR
13 sleep GO:0030431 9.59 OXT OXTR
14 regulation of dopamine metabolic process GO:0042053 9.58 DRD4 SLC6A3
15 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.58 HLA-A HLA-B
16 behavioral response to ethanol GO:0048149 9.57 DRD4 OPRM1
17 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.55 HLA-A HLA-B
18 positive regulation of uterine smooth muscle contraction GO:0070474 9.54 OXT OXTR
19 negative regulation of gastric acid secretion GO:0060455 9.51 OXT OXTR
20 response to progesterone GO:0032570 9.5 OXT OXTR TSPO
21 positive regulation of penile erection GO:0060406 9.49 OXT OXTR
22 protection from natural killer cell mediated cytotoxicity GO:0042270 9.48 HLA-A HLA-B
23 sperm ejaculation GO:0042713 9.46 OXT OXTR
24 response to amphetamine GO:0001975 9.43 DRD4 OXT OXTR
25 positive regulation of norepinephrine secretion GO:0010701 9.4 OXT OXTR
26 regulation of digestive system process GO:0044058 9.16 OXT OXTR
27 eating behavior GO:0042755 9.13 OPRM1 OXT OXTR
28 response to cocaine GO:0042220 8.92 OPRM1 OXT OXTR SLC6A3

Molecular functions related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 CORT OXT PRL
2 dopamine binding GO:0035240 8.62 DRD4 SLC6A3
Sources

Sources for Separation Anxiety Disorder

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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