MCID: SPR012
MIFTS: 40

Separation Anxiety Disorder

Categories: Mental diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Separation Anxiety Disorder

MalaCards integrated aliases for Separation Anxiety Disorder:

Name: Separation Anxiety Disorder 11 75 14 16 71 33
Separation Anxiety Disorder of Childhood 71 31

Classifications:



External Ids:

Disease Ontology 11 DOID:10685
ICD10 31 F93.0
ICD11 33 830200631
UMLS 71 C0003477 C1527281

Summaries for Separation Anxiety Disorder

Disease Ontology: 11 An anxiety disorder that involves the feeling of excessive and inappropriate levels of anxiety over being separated from a person to whom the individual has a strong emotional attachment or place.

MalaCards based summary: Separation Anxiety Disorder, also known as separation anxiety disorder of childhood, is related to anxiety and panic disorder. An important gene associated with Separation Anxiety Disorder is EPRS1 (Glutamyl-Prolyl-TRNA Synthetase 1), and among its related pathways/superpathways are Sudden infant death syndrome (SIDS) susceptibility pathways and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The drugs Vilazodone Hydrochloride and Serotonin Receptor Agonists have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and cortex, and related phenotypes are nervous system and behavior/neurological

Wikipedia: 75 Separation anxiety disorder (SAD) is an anxiety disorder in which an individual experiences excessive... more...

Related Diseases for Separation Anxiety Disorder

Diseases related to Separation Anxiety Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 anxiety 30.4 TSPO SLC6A4 OXTR OXT MAOA HTR1A
2 panic disorder 30.3 TSPO SLC6A4 MAOA HTR1A DRD4 CRH
3 acute stress disorder 30.2 SLC6A4 OXT CRH BDNF
4 agoraphobia 30.1 SLC6A4 MAOA HTR1A CTU2 CRH COMT
5 bulimia nervosa 30.0 SLC6A4 OXT MAOA DRD4 COMT BDNF
6 tic disorder 29.9 SLC6A4 MAOA HTR1A DRD4 COMT
7 personality disorder 29.8 SLC6A4 OXTR MAOA HTR1A DRD4 CRH
8 social phobia 29.7 SLC6A4 OXTR OXT MAOA HTR1A CTU2
9 post-traumatic stress disorder 29.7 SLC6A4 OXTR OXT MAOA HTR1A CRH
10 dissociative disorder 29.7 SLC6A4 OXT OSTF1 COMT BDNF
11 antisocial personality disorder 29.7 SLC6A4 OXTR OXT MAOA DRD4 COMT
12 mood disorder 29.6 SLC6A4 OXT MAOA HTR1A DRD4 CRH
13 alcohol use disorder 29.6 SLC6A4 MAOA DRD4 CRH COMT BDNF
14 oppositional defiant disorder 29.6 SLC6A4 OXTR OXT OSTF1 MAOA DRD4
15 phobia, specific 29.5 SLC6A4 OXT OSTF1 MAOA HTR1A CTU2
16 eating disorder 29.4 SLC6A4 OXTR OXT HTR1A CRH COMT
17 anorexia nervosa 29.3 SLC6A4 OXT MAOA HTR1A DRD4 CRH
18 alcohol dependence 29.2 TSPO SLC6A4 MAOA HTR1A DRD4 CRH
19 obsessive-compulsive disorder 29.2 SLC6A4 OXTR OXT MAOA HTR1A DRD4
20 major depressive disorder 29.2 TSPO SLC6A4 OXT OSTF1 MAOA HTR1A
21 bipolar disorder 29.2 TSPO SLC6A4 MAOA HTR1A DRD4 CRH
22 generalized anxiety disorder 29.2 TSPO SLC6A4 OXT OSTF1 MAOA HTR1A
23 disease of mental health 28.9 SLC6A4 OXTR OXT MAOA HTR1A EPRS1
24 autism 28.8 TSPO SLC6A4 OXTR OXT MAOA HTR1A
25 autism spectrum disorder 28.8 TSPO SLC6A4 OXTR OXT MAOA HTR1A
26 attention deficit-hyperactivity disorder 27.8 SLC6A4 PLEKHB2 OXTR OXT OSTF1 MAOA
27 adult syndrome 10.3
28 animal phobia 10.3 SLC6A4 OXT
29 severe combined immunodeficiency 10.3
30 cascade stomach 10.3 SLC6A4 HTR1A
31 hypoactive sexual desire disorder 10.3 OXT HTR1A
32 voyeurism 10.3 OXT MAOA
33 pyromania 10.3 SLC6A4 MAOA
34 vagus nerve disease 10.3 HTR1A CRH
35 hyperphenylalaninemia, bh4-deficient, a 10.2
36 dependent personality disorder 10.2
37 obsessive-compulsive personality disorder 10.2 SLC6A4 COMT
38 kluver-bucy syndrome 10.2 SLC6A4 OXT CRH
39 somatization disorder 10.2 SLC6A4 OXT CRH
40 drug psychosis 10.2 HTR1A COMT
41 drug-induced mental disorder 10.2 HTR1A COMT
42 infantile liver failure syndrome 10.2 NBAS EPRS1
43 avoidant personality disorder 10.2 SLC6A4 MAOA DRD4
44 body dysmorphic disorder 10.2 SLC6A4 OXT MAOA
45 atypical autism 10.2 OXTR OXT
46 dissociative amnesia 10.2 CRH BDNF
47 migraine without aura 10.2 SLC6A4 HTR1A DRD4
48 multiple personality disorder 10.2 OXT OSTF1
49 chronic pain 10.2 COMT BDNF
50 conversion disorder 10.2 COMT BDNF

Graphical network of the top 20 diseases related to Separation Anxiety Disorder:



Diseases related to Separation Anxiety Disorder

Symptoms & Phenotypes for Separation Anxiety Disorder

MGI Mouse Phenotypes related to Separation Anxiety Disorder:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.7 BDNF COMT CRH DLGAP2 DRD4 HTR1A
2 behavior/neurological MP:0005386 9.4 BDNF COMT CRH DLGAP2 DRD4 HTR1A

Drugs & Therapeutics for Separation Anxiety Disorder

Drugs for Separation Anxiety Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vilazodone Hydrochloride Phase 4 163521-08-2
2 Serotonin Receptor Agonists Phase 4
3 Serotonin 5-HT1 Receptor Agonists Phase 4
4
Guanfacine Approved, Investigational Phase 2 29110-47-2 3519
5 Adrenergic alpha-Agonists Phase 2
6 Adrenergic Agonists Phase 2
7 Adrenergic Agents Phase 2
8 Antihypertensive Agents Phase 2
9
Sertraline Approved 79617-96-2 68617
10 Neurotransmitter Agents
11 Psychotropic Drugs
12 Antidepressive Agents
13 Serotonin Uptake Inhibitors
14
Serotonin Investigational, Nutraceutical 50-67-9 5202

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Vilazodone for Separation Anxiety Disorder Completed NCT01999920 Phase 4 Vilazodone;Placebo
2 Utilizing Health Information Technology to Improve Health Care Quality: Implementation of a Computerized Cognitive Behavioral Therapy Protocol for Childhood Anxiety Completed NCT01416805 Phase 3
3 Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders Completed NCT01178385 Phase 2, Phase 3
4 A Phase 2, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Assess the Safety and Tolerability of SPD503 in Subjects Aged 6-17 Years With Generalized Anxiety Disorder (GAD), Separation Anxiety Disorder (SAD), or Social Phobia (SoP). Completed NCT01470469 Phase 2 SPD503 (extended-release Guanfacine hydrochloride);Placebo
5 Effectiveness of Group and Individual Treatment of Childhood Anxiety Disorders in Community Clinics. A Randomized Controlled Trial. Completed NCT00735995 Phase 2
6 A Brief Behavioral Treatment for Anxiety in Young Children Completed NCT02051192 Phase 1, Phase 2
7 Effects of Parental Behavior on Child Anxiety Regulation Completed NCT00593515 Phase 2
8 Assessment and Treatment - Anxiety in Children and Adults (Child Part) Completed NCT00586586 Phase 2
9 A Randomized, Controlled Trial of Modular CBT for Child Anxiety Disorders in Elementary School Settings Completed NCT00569829 Phase 2
10 Feasible Delivery of CBT for Rural Latino Youth With Anxiety Completed NCT01491880 Phase 1, Phase 2
11 Combination of Active or Placebo Attentional Bias Modification Treatment (ABMT) to Either Cognitive Behavioral Group Therapy (CBGT) or Psychoeducational Control Intervention (PCI) for Anxiety Disorders in Children: a Randomized Clinical Trial Unknown status NCT01687764
12 Psychological Treatment of Separation Anxiety Disorder Completed NCT00255112
13 Sleep, Mood, and Behavior Study:Transdisciplinary Studies of CBT for Anxiety in Youth Completed NCT00787397
14 Transdisciplinary Studies of CBT for Anxiety in Youth Completed NCT00774150
15 2/3 Treatment of Anxiety in Autism Spectrum Disorder Completed NCT02028247
16 Exposure-Focused Family-Based CBT for Youth With ASD and Comorbid Anxiety Completed NCT01919970
17 Dimensional Brain Behavior Predictors of CBT Outcomes in Pediatric Anxiety Completed NCT02810171
18 Decision-Making Processes and Brain Function in Anxiety-Disordered and Non-Anxious Youth Completed NCT00104195
19 Cognitive Behavioral Therapy for Anxiety Disorders in Adolescents With Autism Completed NCT01563003
20 Brain Markers of Anxiety Disorders and SSRI/CBT Treatment in Children and Adolescents Completed NCT01160588 Sertraline
21 Computer- Assisted Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders Completed NCT01565629
22 Building an Outcomes Assessment Infrastructure to Assess Youth in the McLean Anxiety Mastery Program at McLean Hospital Recruiting NCT02305537
23 Brain Response Associated With Parent-based Treatment for Childhood Anxiety Disorders Recruiting NCT03585010
24 Web-based Attention Bias Modification Treatment for Childhood Anxiety Disorders: a Randomized, Double-blind, Controlled Trial Terminated NCT03764644
25 Attention Bias Modification Treatment for Anxious Youth Terminated NCT01979263
26 Acoustic Neuromodulation (ANM) for Youth With Anxiety Disorders: A Pilot Study Terminated NCT02572973
27 Treatment of Pediatric Anxiety Disorders by Predicting Treatment Response Through Biocellular Markers and Sleep Terminated NCT02189213 Sertraline

Search NIH Clinical Center for Separation Anxiety Disorder

Genetic Tests for Separation Anxiety Disorder

Anatomical Context for Separation Anxiety Disorder

Organs/tissues related to Separation Anxiety Disorder:

MalaCards : Brain, Prefrontal Cortex, Cortex, Eye, Heart, Skin

Publications for Separation Anxiety Disorder

Articles related to Separation Anxiety Disorder:

(show top 50) (show all 651)
# Title Authors PMID Year
1
Anxiety disorders, depression and incontinence in preschool children-A population-based study. 62
35979705 2022
2
Prevalence and Phenomenology of Anxiety in Preschool-Aged Children with Autism Spectrum Disorder. 62
36048376 2022
3
Prenatal exposure to a natural disaster and early development of psychiatric disorders during the preschool years: stress in pregnancy study. 62
36129196 2022
4
Pre-existing Mental Health Diagnoses Are Associated With Higher Rates of Postoperative Complications, Readmissions, and Reoperations Following Arthroscopic Rotator Cuff Repair. 62
35970453 2022
5
Reliability and validity of the DSM-5 Diagnostic Interview Schedule for Children, Adolescents, and Parents-5 in externalizing disorders and common comorbidities. 62
35038264 2022
6
Relationship of behavioral inhibition to separation anxiety in a sample (N = 377) of adult individuals with mood and anxiety disorders. 62
35569286 2022
7
Factor structure of the Chinese version of the Screen for Adult Anxiety Related Disorders (SCARRED). 62
35580532 2022
8
Psychiatric comorbidity associated with weight status in 9 to 10 year old children. 62
35048539 2022
9
Do Children of Patients with Bipolar Disorder have a Worse Perception of Sleep Quality? 62
35210211 2022
10
COVID-19-Related Stigma and Mental Health of Children and Adolescents During Pandemic. 62
34878913 2022
11
Mental disorders and their comorbidities among children and adolescents aged 6 to 18 years in Lorestan Province. 62
35222656 2022
12
Prevalence of Psychiatric Disorders among Children and Adolescents: A Study from Khuzestan. 62
36204445 2022
13
Do Metacognitions of Children and Adolescents with Anxiety Disorders Change after Intensified Exposure Therapy? 62
35204889 2022
14
Prediction of anxiety disorders using a feature ensemble based bayesian neural network. 62
34628061 2021
15
Separation Anxiety Disorder. 62
34751707 2021
16
Relationship Between Adult Separation Anxiety and Attachment Styles and Vaginismus. 62
34417127 2021
17
Pediatric anxiety associated with altered facial emotion recognition. 62
34146888 2021
18
EEG correlates of attentional control in anxiety disorders: A systematic review of error-related negativity and correct-response negativity findings. 62
34038831 2021
19
What Event-Related Potential Tells Us about Brain Function: Child-Adolescent Psychiatric Perspectives. 62
34285633 2021
20
Neighborhood characteristics and psychiatric disorders in the aftermath of mass trauma: A representative study of New York City public school 4th-12th graders after 9/11. 62
33992981 2021
21
[Separation anxiety disorder]. 62
33319254 2021
22
Liraglutide combined with intense lifestyle modification in the management of obesity in adolescents. 62
33823101 2021
23
Are anxiety disorders a pathway to obsessive-compulsive disorder? Different trajectories of OCD and the role of death anxiety. 62
32921190 2021
24
Separation Anxiety and Measures of Suicide Risk Among Patients With Mood and Anxiety Disorders. 62
33989461 2021
25
Separation anxiety disorder among outpatients with major depressive disorder: Prevalence and clinical correlates. 62
33378709 2021
26
The Children's Revised Impact of Event Scale: Dimensionality and Measurement Invariance in a Sample of Children and Adolescents Exposed to Wildfires. 62
33245801 2021
27
Portuguese validation of the Adult Separation Anxiety-Questionnaire (ASA-27). 62
33690669 2021
28
Separation Anxiety-An Unseen Cause for Development of Abnormal Oral and Paraoral Habits and Malocclusion: A Review of Literature and Report of Two Cases. 62
35645476 2021
29
Separation Anxiety Disorder in Panic Disorder Patients with and without Comorbid Agoraphobia. 62
33577430 2021
30
[Clinical variants and types of course of separation anxiety disorder in adults]. 62
34184473 2021
31
The Role of Social Media Use in Peer Bullying Victimization and Onset of Anxiety Among Indonesian Elementary School Children. 62
33995192 2021
32
Personalized Assessment of Anxiety and Avoidance in Children and Their Parents-Development and Evaluation of the Anxiety and Avoidance Scale for Children. 62
34867587 2021
33
Psychiatric comorbidity of developmental trauma disorder and posttraumatic Stress disorder: findings from the DTD field trial replication (DTDFT-R). 62
34249242 2021
34
Association Between Family Structure and Anxiety Disorder Among Pre-schoolers: A Cross-Sectional Study in Urban Chongqing, China. 62
34721092 2021
35
Psychometrics of the Spanish Version of the Screen for Adult Anxiety Related Disorders (SCAARED). 62
33643088 2021
36
Prevalence, Comorbidity and Predictor of Separation Anxiety Disorder in Children and Adolescents. 62
32418141 2020
37
Psychometric Properties of the SCARED in a Nationally Representative U.S. Sample of 5-12-Year-Olds. 62
31136197 2020
38
Psychometric Evaluation of the Child and Parent Versions of the Coping Questionnaire. 62
32157488 2020
39
Clinical reappraisal of the Composite International Diagnostic Interview Version 3.0 in the Saudi National Mental Health Survey. 62
33245606 2020
40
The relationship between separation anxiety and intolerance of uncertainty in pregnant women. 62
30585096 2020
41
Gaze-Contingent Music Reward Therapy for Clinically Anxious 7- to 10-Year-Olds: An Open Multiple Baseline Feasibility Study. 62
30908085 2020
42
Do Children of Patients with Bipolar Disorder have a Worse Perception of Sleep Quality? 62
33735036 2020
43
Internet-delivered cognitive behavior therapy with minimal therapist support for anxious children and adolescents: predictors of response. 62
32424896 2020
44
Childhood and adolescent mental health of NICU graduates: an observational study. 62
31974300 2020
45
Accuracy of the Diagnostic Infant and Preschool Assessment (DIPA) in a Dutch sample. 62
32360141 2020
46
eMental Health Literacy and Knowledge of Common Child Mental Health Disorders among Parents of Preschoolers. 62
32400237 2020
47
The Diagnostic Infant Preschool Assessment-Likert Version: Preparation, Concurrent Construct Validation, and Test-Retest Reliability. 62
32159386 2020
48
Adult Separation Anxiety Disorder Symptomology as a Risk Factor for Thin-Ideal Internalization: The Role of Self-Concept Clarity. 62
30744502 2020
49
Adult separation anxiety disorder: The human-animal bond. 62
32339110 2020
50
Separation Anxiety Symptom Profiles and Parental Accommodation Across Pediatric Anxiety Disorders. 62
31907734 2020

Variations for Separation Anxiety Disorder

Expression for Separation Anxiety Disorder

Search GEO for disease gene expression data for Separation Anxiety Disorder.

Pathways for Separation Anxiety Disorder

GO Terms for Separation Anxiety Disorder

Biological processes related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of synapse assembly GO:0051965 10 OXTR OXT BDNF
2 maternal behavior GO:0042711 9.88 OXTR OXT
3 synaptic transmission, dopaminergic GO:0001963 9.87 DRD4 CRH
4 sleep GO:0030431 9.86 OXTR OXT
5 memory GO:0007613 9.86 BDNF OXT OXTR SLC6A4
6 regulation of dopamine metabolic process GO:0042053 9.85 HTR1A DRD4
7 response to progesterone GO:0032570 9.85 TSPO OXTR OXT
8 dopamine catabolic process GO:0042420 9.81 MAOA COMT
9 positive regulation of uterine smooth muscle contraction GO:0070474 9.8 OXTR OXT
10 response to amphetamine GO:0001975 9.8 OXTR OXT DRD4
11 neurotransmitter catabolic process GO:0042135 9.78 MAOA COMT
12 positive regulation of penile erection GO:0060406 9.76 OXT OXTR
13 negative regulation of gastric acid secretion GO:0060455 9.73 OXT OXTR
14 positive regulation of norepinephrine secretion GO:0010701 9.71 OXTR OXT
15 social behavior GO:0035176 9.56 SLC6A4 OXTR OXT DRD4
16 catecholamine metabolic process GO:0006584 9.54 MAOA COMT
17 regulation of digestive system process GO:0044058 9.16 OXTR OXT
18 sperm ejaculation GO:0042713 9.1 SLC6A4 OXTR OXT

Molecular functions related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serotonin binding GO:0051378 8.92 SLC6A4 HTR1A

Sources for Separation Anxiety Disorder

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....