MCID: SPR012
MIFTS: 38

Separation Anxiety Disorder

Categories: Mental diseases

Aliases & Classifications for Separation Anxiety Disorder

MalaCards integrated aliases for Separation Anxiety Disorder:

Name: Separation Anxiety Disorder 12 74 15 17 71
Separation Anxiety Disorder of Childhood 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:10685
ICD10 32 F93.0
UMLS 71 C0003477 C1527281

Summaries for Separation Anxiety Disorder

Disease Ontology : 12 An anxiety disorder that involves the feeling of excessive and inappropriate levels of anxiety over being separated from a person to whom the individual has a strong emotional attachment or place.

MalaCards based summary : Separation Anxiety Disorder, also known as separation anxiety disorder of childhood, is related to personality disorder and anxiety. An important gene associated with Separation Anxiety Disorder is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Neurotransmitter Clearance In The Synaptic Cleft and Methylphenidate Pathway, Pharmacodynamics. The drugs Midazolam and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and eye, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 74 Separation anxiety disorder (SAD) is an anxiety disorder in which an individual experiences excessive... more...

Related Diseases for Separation Anxiety Disorder

Diseases related to Separation Anxiety Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 personality disorder 30.8 SLC6A4 SLC6A3 DRD4
2 anxiety 30.8 SLC6A4 SLC6A3 OXT OPRM1 DRD4
3 obsessive-compulsive disorder 30.1 SLC6A4 SLC6A3 OXT DRD4
4 eating disorder 30.0 SLC6A4 SLC6A3 OPRM1
5 acute stress disorder 29.8 SLC6A4 OXT MHRT
6 dependent personality disorder 29.8 WASF2 WASF1 DRD4
7 bulimia nervosa 29.7 SLC6A4 OXT DRD4
8 agoraphobia 29.7 WASF2 WASF1 SLC6A4 NBAS
9 major depressive disorder 29.6 SLC6A4 SLC6A3 OXT OPRM1 DRD4
10 tic disorder 29.6 SLC6A4 SLC6A3 RTN4 DRD4
11 anorexia nervosa 29.5 SLC6A4 OXT DRD4
12 alcohol dependence 29.3 SLC6A4 SLC6A3 OXT OPRM1 DRD4
13 attention deficit-hyperactivity disorder 29.2 SLC6A4 SLC6A3 OXT OPRM1 DRD4
14 autism spectrum disorder 29.2 SLC6A4 SLC6A3 OXT OPRM1 DRD4
15 avoidant personality disorder 29.0 WASF2 WASF1 SLC6A4 SLC6A3 DRD4
16 social phobia 28.2 WASF2 WASF1 SLC6A4 OXT NBAS MHRT
17 mental depression 28.1 WASF2 WASF1 SLC6A4 SLC6A3 PROC OXT
18 antisocial personality disorder 27.8 WASF2 WASF1 SLC6A4 SLC6A3 RTN4 DRD4
19 disease of mental health 26.4 WASF2 WASF1 TOR3A SLC6A4 SLC6A3 RTN4
20 oppositional defiant disorder 26.2 WASF2 WASF1 TOR3A SLC6A4 SLC6A3 RTN4
21 phobia, specific 26.0 WASF2 WASF1 TOR3A SLC6A4 RTN4 PROC
22 panic disorder 10.5
23 lung mixed small cell and squamous cell carcinoma 10.4 OPRM1 ASPRV1
24 substance-induced psychosis 10.4 SLC6A3 DRD4
25 chronic tic disorder 10.4 DRD4 CGAS
26 cyclothymic disorder 10.4 DRD4 CGAS
27 alcoholic psychosis 10.4 SLC6A4 SLC6A3
28 delusional disorder 10.3 SLC6A3 DRD4
29 barbiturate dependence 10.3 SLC6A4 OPRM1
30 amphetamine abuse 10.3 SLC6A4 SLC6A3 DRD4
31 schizophreniform disorder 10.2 DRD4 CGAS
32 cocaine dependence 10.2 SLC6A4 SLC6A3 OPRM1
33 drug dependence 10.2 SLC6A4 SLC6A3 OPRM1
34 severe combined immunodeficiency 10.2
35 opioid abuse 10.2 OPRM1 DRD4
36 migraine with aura 10.2 SLC6A4 SLC6A3 OPRM1
37 animal phobia 10.2 OXT ASPRV1
38 generalized anxiety disorder 10.2
39 hypochondriasis 10.2 SLC6A4 MHRT
40 anosognosia 10.2 RTN4 ASPRV1
41 speech disorder 10.2 TOR3A EPRS1 ASPRV1
42 gilles de la tourette syndrome 10.2 SLC6A4 SLC6A3 DRD4
43 heroin dependence 10.1 SLC6A4 SLC6A3 OPRM1 DRD4
44 myasthenic syndrome, congenital, 1a, slow-channel 10.1 OXT OPRM1
45 opiate dependence 10.1 SLC6A4 SLC6A3 OPRM1 DRD4
46 conduct disorder 10.1 SLC6A4 SLC6A3 NBAS DRD4
47 psychosexual disorder 10.1 SLC6A4 OXT
48 dyslexia 10.1 TOR3A SLC6A3 DRD4 ASPRV1
49 mood disorder 10.1
50 depression 10.1

Graphical network of the top 20 diseases related to Separation Anxiety Disorder:



Diseases related to Separation Anxiety Disorder

Symptoms & Phenotypes for Separation Anxiety Disorder

MGI Mouse Phenotypes related to Separation Anxiety Disorder:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 CCDC85B CGAS DRD4 LXN NBAS OPRM1
2 nervous system MP:0003631 9.32 DRD4 NBAS OPRM1 OXT PROC RTN4

Drugs & Therapeutics for Separation Anxiety Disorder

Drugs for Separation Anxiety Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
2
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
3 Antidepressive Agents Phase 4
4 Serotonin 5-HT1 Receptor Agonists Phase 4
5 Serotonin Receptor Agonists Phase 4
6 Psychotropic Drugs Phase 4
7 Serotonin Uptake Inhibitors Phase 4
8 Vilazodone Hydrochloride Phase 4 163521-08-2
9 Neurotransmitter Agents Phase 4
10 Anesthetics Phase 4
11 Excitatory Amino Acid Antagonists Phase 4
12 Hypnotics and Sedatives Phase 4
13 Anesthetics, Dissociative Phase 4
14 Anti-Anxiety Agents Phase 4
15 Anesthetics, General Phase 4
16 GABA Modulators Phase 4
17 Anesthetics, Intravenous Phase 4
18 Analgesics Phase 4
19
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
20
Guanfacine Approved, Investigational Phase 2 29110-47-2 3519
21 Adrenergic alpha-Agonists Phase 2
22 Antihypertensive Agents Phase 2
23 Adrenergic Agents Phase 2
24 Adrenergic Agonists Phase 2
25
Citalopram Approved Phase 1 59729-33-8 2771
26
Hydrocortisone acetate Approved, Vet_approved Phase 1 50-03-3
27
Hydrocortisone Approved, Vet_approved Phase 1 50-23-7 5754
28 Hydrocortisone 17-butyrate 21-propionate Phase 1
29 Hydrocortisone hemisuccinate Phase 1

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Vilazodone for Separation Anxiety Disorder Completed NCT01999920 Phase 4 Vilazodone;Placebo
2 Efficacy of Rapid-Acting NMDA Antagonist for Treatment of Adolescent Depression and Anxiety Disorders Completed NCT02579928 Phase 4 Ketamine;Midazolam
3 A Randomized Controlled Trial of Multimodal Music Therapy for Children With Anxiety Disorders Completed NCT01062646 Phase 3
4 2/3 Treatment of Anxiety in Autism Spectrum Disorder Completed NCT02028247 Phase 3
5 Utilizing Health Information Technology to Improve Health Care Quality: Implementation of a Computerized Cognitive Behavioral Therapy Protocol for Childhood Anxiety Completed NCT01416805 Phase 3
6 Effectiveness of Group and Individual Treatment of Childhood Anxiety Disorders in Community Clinics. A Randomized Controlled Trial. Completed NCT00735995 Phase 2
7 A Phase 2, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Assess the Safety and Tolerability of SPD503 in Subjects Aged 6-17 Years With Generalized Anxiety Disorder (GAD), Separation Anxiety Disorder (SAD), or Social Phobia (SoP). Completed NCT01470469 Phase 2 SPD503 (extended-release Guanfacine hydrochloride);Placebo
8 A Randomized, Controlled Trial of Modular CBT for Child Anxiety Disorders in Elementary School Settings Completed NCT00569829 Phase 2
9 Assessment and Treatment - Anxiety in Children and Adults (Child Part) Completed NCT00586586 Phase 2
10 Effects of Parental Behavior on Child Anxiety Regulation Completed NCT00593515 Phase 2
11 A Brief Behavioral Treatment for Anxiety in Young Children Completed NCT02051192 Phase 1, Phase 2
12 Feasible Delivery of CBT for Rural Latino Youth With Anxiety Completed NCT01491880 Phase 1, Phase 2
13 Cipralex® for Anxiety Disorders in Adolescents: Clinical and Physiological Changes Associated With Open Label, Flexible-dose Treatment Unknown status NCT01293838 Phase 1 Cipralex®
14 Effectiveness of Cognitive-Behavioral Therapy for Children With High-Functioning Autism Spectrum Disorder and Anxiety Completed NCT01187784 Phase 1
15 Comorbidity Between Balance and Childhood Anxiety: Treatment of Anxiety by Training of Balance Unknown status NCT00599742
16 Investigating the Effects of an Added Parent Component to Cognitive Behavior Therapy for Youth With Anxiety Disorders Unknown status NCT02160444
17 Combination of Active or Placebo Attentional Bias Modification Treatment (ABMT) to Either Cognitive Behavioral Group Therapy (CBGT) or Psychoeducational Control Intervention (PCI) for Anxiety Disorders in Children: a Randomized Clinical Trial Unknown status NCT01687764
18 Psychological Treatment of Separation Anxiety Disorder Completed NCT00255112
19 Internet-Based CBT for Children With Anxiety Disorders: Implementation in Clinical Settings Completed NCT02350257
20 Internet-delivered Cognitive Behavior Therapy (CBT) Treatment for Anxiety Disorders in Children Age 8-12 Years - a Randomised Controlled Trial Completed NCT01533402
21 Transdisciplinary Studies of CBT for Anxiety in Youth Completed NCT00774150
22 Sleep, Mood, and Behavior Study:Transdisciplinary Studies of CBT for Anxiety in Youth Completed NCT00787397
23 Exposure-Focused Family-Based CBT for Youth With ASD and Comorbid Anxiety Completed NCT01919970
24 Ventilatory Physiology in Children at Risk for Anxiety Completed NCT00101777
25 Early Interventions for Anxious Children Completed NCT00557648
26 Enhancing Specificity and Predictability of CBT Outcome for Pediatric Anxiety Disorders: A Pilot Test of a Potential Biomarker for Treatment Response Across Development Completed NCT03032926
27 Reward-Related Processes and Brain Function Completed NCT00029588
28 Psychotherapy Process and Outcomes in Cognitive-Behavioral Treatment for Anxious and Depressed Youth Recruiting NCT03100279
29 Attention Bias Modification Treatment for Anxious Youth Terminated NCT01979263
30 Acoustic Neuromodulation (ANM) for Youth With Anxiety Disorders: A Pilot Study Terminated NCT02572973

Search NIH Clinical Center for Separation Anxiety Disorder

Genetic Tests for Separation Anxiety Disorder

Anatomical Context for Separation Anxiety Disorder

MalaCards organs/tissues related to Separation Anxiety Disorder:

40
Testes, Brain, Eye, Cortex, Heart, Skin, Prefrontal Cortex

Publications for Separation Anxiety Disorder

Articles related to Separation Anxiety Disorder:

(show top 50) (show all 607)
# Title Authors PMID Year
1
Childhood and adolescent mental health of NICU graduates: an observational study. 61
31974300 2020
2
Accuracy of the Diagnostic Infant and Preschool Assessment (DIPA) in a Dutch sample. 61
32360141 2020
3
eMental Health Literacy and Knowledge of Common Child Mental Health Disorders among Parents of Preschoolers. 61
32400237 2020
4
Separation Anxiety Symptom Profiles and Parental Accommodation Across Pediatric Anxiety Disorders. 61
31907734 2020
5
Adult separation anxiety disorder: The human-animal bond. 61
32339110 2020
6
Adult Separation Anxiety Disorder Symptomology as a Risk Factor for Thin-Ideal Internalization: The Role of Self-Concept Clarity. 61
30744502 2020
7
Internet-delivered cognitive behavior therapy with minimal therapist support for anxious children and adolescents: predictors of response. 61
32424896 2020
8
Prevalence, Comorbidity and Predictor of Separation Anxiety Disorder in Children and Adolescents. 61
32418141 2020
9
Associations between family factors, childhood adversity, negative life events and child anxiety disorders: an exploratory study of diagnostic specificity. 61
31727188 2020
10
Separation anxiety in PTSD: A pilot study of mechanisms in patients undergoing IPT. 61
32097526 2020
11
A neurobiological framework of separation anxiety and related phenotypes. 61
32046934 2020
12
Lifetime prevalence, sociodemographic predictors, and comorbidities of oppositional defiant disorder: the National Epidemiology of Iranian Child and Adolescent Psychiatric disorders (IRCAP). 61
31433003 2020
13
The Mental Health of Young Canadian Mothers. 61
32057608 2020
14
Anxiety disorders comorbidity in pediatric bipolar disorder: a meta-analysis and meta-regression study. 61
31899546 2020
15
The Diagnostic Infant Preschool Assessment-Likert Version: Preparation, Concurrent Construct Validation, and Test-Retest Reliability. 61
32159386 2020
16
Editorial: Parent-Based Treatment for Childhood Anxiety. 61
31128270 2020
17
Systematic Review and Meta-Analysis of Anxiety and Depression in Youth With Epilepsy. 61
31904859 2020
18
Psychometric Evaluation of the Child and Parent Versions of the Coping Questionnaire. 61
32157488 2020
19
When to Raise Our White Flag-A Discussion of Scope of Practice in a Resource Scarce World. 61
31917736 2020
20
Emotional and Behavioral Disorders in Pediatric Cancer Patients. 61
32021635 2020
21
The Role of the Oxytocin System in Anxiety Disorders. 61
32002925 2020
22
The Impact of Treatment Expectations on Exposure Process and Treatment Outcome in Childhood Anxiety Disorders. 61
31313062 2020
23
Anxiety Disorders in the DSM-5: Changes, Controversies, and Future Directions. 61
32002930 2020
24
Evaluation of neuropsychiatric comorbidities and their clinical characteristics in Chinese children with asthma using the MINI kid tool. 61
31752780 2019
25
Anxiety and Fear-Related Disorders in the ICD-11: Results from a Global Case-controlled Field Study. 61
32018071 2019
26
Body Mass Index Status across Different Psychiatric Disorders in a National Survey amongst Children and Adolescents: To Identify the Role of Gender. 61
32071598 2019
27
Anxiety disorders anticipate the diagnosis of bipolar disorder in comorbid patients: Findings from an Italian tertiary clinic. 61
31302527 2019
28
Psychopharmacology in Pediatric Mixed Anxiety Disorder: An Evidence-based Review. 61
32082949 2019
29
Psychopharmacology of Pediatric Anxiety Disorders: A Narrative Review. 61
31656713 2019
30
The characteristics of the comorbidity between social anxiety and separation anxiety disorders in adult patients. 61
31322453 2019
31
The utility of the SCAS-C/P to detect specific anxiety disorders among clinically anxious children. 61
31070449 2019
32
Emotional Awareness Predicts Specific Cognitive-Behavioral Therapy Outcomes for Anxious Youth. 61
30603936 2019
33
The 2014 Ontario Child Health Study Emotional Behavioural Scales (OCHS-EBS) Part I: A Checklist for Dimensional Measurement of Selected DSM-5 Disorders. 61
30376365 2019
34
An Analysis of the Child Behavior Checklist Anxiety Problems Scale's Predictive Capabilities. 61
31666760 2019
35
Associations of child and adolescent anxiety with later alcohol use and disorders: a systematic review and meta-analysis of prospective cohort studies. 61
30891835 2019
36
The 2014 Ontario Child Health Study Emotional Behavioural Scales (OCHS-EBS) Part II: Psychometric Adequacy for Categorical Measurement of Selected DSM-5 Disorders. 61
30376363 2019
37
[Psychoanalytic therapy for a child with somnambulism: a case report]. 61
31140411 2019
38
Psychometric Properties of the SCARED in a Nationally Representative U.S. Sample of 5-12-Year-Olds. 61
31136197 2019
39
Rates, types and co-occurrence of emotional and behavioural disorders among perinatally HIV-infected youth in Uganda: the CHAKA study. 61
30788554 2019
40
Posttraumatic Stress Disorder and Psychiatric Comorbidity among Adolescent Earthquake Survivors: a Longitudinal Cohort Study. 61
30167997 2019
41
Gaze-Contingent Music Reward Therapy for Clinically Anxious 7- to 10-Year-Olds: An Open Multiple Baseline Feasibility Study. 61
30908085 2019
42
Altered Uncinate Fasciculus Microstructure in Childhood Anxiety Disorders in Boys But Not Girls. 61
30654645 2019
43
Screening for depressive and anxiety disorders among adolescents in Indonesia: Formal validation of the centre for epidemiologic studies depression scale - revised and the Kessler psychological distress scale. 61
30583144 2019
44
Psychiatric disorders in children and adolescents: Prevalence and sociodemographic correlates in Semnan Province in Iran. 61
30673624 2019
45
Help me Feel Better! Ecological Momentary Assessment of Anxious Youths' Emotion Regulation with Parents and Peers. 61
29946887 2019
46
PANDAS versus Hashimoto`s encephalopathy: a diagnostic dilemma in a Saudi girl. 61
31969744 2019
47
Comorbidity of developmental trauma disorder (DTD) and post-traumatic stress disorder: findings from the DTD field trial. 61
30728917 2019
48
Examining the Hierarchical Influences of the Big-Five Dimensions and Anxiety Sensitivity on Anxiety Symptoms in Children. 61
31231271 2019
49
Systematic Review and Meta-Analysis: Anxiety and Depressive Disorders in Offspring of Parents With Anxiety Disorders. 61
30577938 2019
50
Transgenerational improvements following child anxiety treatment: An exploratory examination. 61
30817752 2019

Variations for Separation Anxiety Disorder

Expression for Separation Anxiety Disorder

Search GEO for disease gene expression data for Separation Anxiety Disorder.

Pathways for Separation Anxiety Disorder

Pathways related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.35 SLC6A4 SLC6A3
2
Show member pathways
10.16 SLC6A4 SLC6A3 DRD4

GO Terms for Separation Anxiety Disorder

Cellular components related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SCAR complex GO:0031209 9.16 WASF2 WASF1
2 integral component of presynaptic membrane GO:0099056 9.13 SLC6A4 SLC6A3 OPRM1
3 integral component of postsynaptic membrane GO:0099055 8.8 SLC6A4 SLC6A3 OPRM1

Biological processes related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 eating behavior GO:0042755 9.51 OXT OPRM1
2 Rac protein signal transduction GO:0016601 9.49 WASF2 WASF1
3 response to food GO:0032094 9.48 OXT OPRM1
4 behavioral response to ethanol GO:0048149 9.46 OPRM1 DRD4
5 neurotransmitter biosynthetic process GO:0042136 9.43 SLC6A4 SLC6A3
6 positive regulation of Arp2/3 complex-mediated actin nucleation GO:2000601 9.4 WASF2 WASF1
7 regulation of dopamine metabolic process GO:0042053 9.37 SLC6A3 DRD4
8 social behavior GO:0035176 9.33 SLC6A4 OXT DRD4
9 monoamine transport GO:0015844 9.32 SLC6A4 SLC6A3
10 lamellipodium morphogenesis GO:0072673 9.26 WASF2 WASF1
11 sperm ejaculation GO:0042713 8.96 SLC6A4 OXT
12 response to cocaine GO:0042220 8.8 SLC6A3 OXT OPRM1

Molecular functions related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase A regulatory subunit binding GO:0034237 9.37 WASF2 WASF1
2 protein kinase A binding GO:0051018 9.32 WASF2 WASF1
3 neurotransmitter:sodium symporter activity GO:0005328 9.26 SLC6A4 SLC6A3
4 Arp2/3 complex binding GO:0071933 9.16 WASF2 WASF1
5 dopamine binding GO:0035240 8.96 SLC6A3 DRD4
6 monoamine transmembrane transporter activity GO:0008504 8.62 SLC6A4 SLC6A3

Sources for Separation Anxiety Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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