MCID: SPS090
MIFTS: 27

Sepsis in Premature Infants

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Sepsis in Premature Infants

MalaCards integrated aliases for Sepsis in Premature Infants:

Name: Sepsis in Premature Infants 58

Characteristics:

Orphanet epidemiological data:

58
sepsis in premature infants
Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases


Summaries for Sepsis in Premature Infants

MalaCards based summary : Sepsis in Premature Infants is related to enterocolitis and chorioamnionitis. An important gene associated with Sepsis in Premature Infants is CALCA (Calcitonin Related Polypeptide Alpha). Affiliated tissues include bone, liver and lung, and related phenotypes are premature birth and tachycardia

Related Diseases for Sepsis in Premature Infants

Diseases related to Sepsis in Premature Infants via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 enterocolitis 10.0
2 chorioamnionitis 10.0
3 funisitis 10.0
4 endocarditis 10.0
5 rickets 10.0
6 lung disease 10.0
7 bacterial meningitis 10.0
8 external ear carcinoma 9.9 CRP CALCA
9 neurogenic arthropathy 9.9 CRP CALCA
10 discitis 9.9 CRP CALCA
11 plantar fasciitis 9.9 CRP CALCA
12 acute cholangitis 9.9 CRP CALCA
13 bursitis 9.9 CRP CALCA
14 suppurative thyroiditis 9.9 CRP CALCA
15 thyroiditis 9.9 CRP CALCA
16 raynaud disease 9.9 CRP CALCA
17 chronic pyelonephritis 9.8 CRP CALCA
18 pyelonephritis 9.8 CRP CALCA
19 erysipelas 9.8 CRP CALCA
20 decubitus ulcer 9.8 CRP CALCA
21 viral meningitis 9.8 CRP CALCA
22 acute pyelonephritis 9.8 CRP CALCA
23 nodular goiter 9.8 CRP CALCA
24 septic arthritis 9.8 CRP CALCA
25 aseptic meningitis 9.8 CRP CALCA
26 mineral metabolism disease 9.8 CRP CALCA
27 bacterial sepsis 9.8 CRP CALCA
28 agnosia 9.8 CRP CALCA
29 ileus 9.8 CRP CALCA
30 osteomyelitis 9.8 CRP CALCA
31 bacterial pneumonia 9.8 CRP CALCA
32 fibromyalgia 9.8 CRP CALCA
33 thyroid gland disease 9.8 CRP CALCA
34 bone resorption disease 9.8 CRP CALCA
35 bone remodeling disease 9.8 CRP CALCA
36 gastroenteritis 9.8 CRP CALCA
37 inguinal hernia 9.8 CRP CALCA
38 hyperthyroidism 9.8 CRP CALCA
39 constipation 9.7 CRP CALCA
40 migraine with or without aura 1 9.7 CRP CALCA
41 tetralogy of fallot 9.7 CRP CALCA
42 peripheral nervous system disease 9.7 CRP CALCA
43 hypothyroidism 9.7 CRP CALCA
44 connective tissue disease 9.6 CRP CALCA
45 pheochromocytoma 9.6 CRP CALCA
46 osteoporosis 9.5 CRP CALCA

Graphical network of the top 20 diseases related to Sepsis in Premature Infants:



Diseases related to Sepsis in Premature Infants

Symptoms & Phenotypes for Sepsis in Premature Infants

Human phenotypes related to Sepsis in Premature Infants:

58 31 (show top 50) (show all 51)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 premature birth 58 31 hallmark (90%) Very frequent (99-80%) HP:0001622
2 tachycardia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001649
3 small for gestational age 58 31 hallmark (90%) Very frequent (99-80%) HP:0001518
4 neonatal sepsis 58 31 hallmark (90%) Very frequent (99-80%) HP:0040187
5 neonatal hypotonia 58 31 frequent (33%) Frequent (79-30%) HP:0001319
6 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
7 pallor 58 31 frequent (33%) Frequent (79-30%) HP:0000980
8 neutropenia 58 31 frequent (33%) Frequent (79-30%) HP:0001875
9 metabolic acidosis 58 31 frequent (33%) Frequent (79-30%) HP:0001942
10 elevated c-reactive protein level 58 31 frequent (33%) Frequent (79-30%) HP:0011227
11 abdominal distention 58 31 frequent (33%) Frequent (79-30%) HP:0003270
12 leukocytosis 58 31 frequent (33%) Frequent (79-30%) HP:0001974
13 gastrointestinal dysmotility 58 31 frequent (33%) Frequent (79-30%) HP:0002579
14 caesarian section 58 31 frequent (33%) Frequent (79-30%) HP:0011410
15 abnormal mucociliary clearance 58 31 frequent (33%) Frequent (79-30%) HP:0031602
16 severe infection 58 31 frequent (33%) Frequent (79-30%) HP:0032169
17 increased circulating interleukin 6 31 frequent (33%) HP:0030783
18 hypotension 58 31 occasional (7.5%) Occasional (29-5%) HP:0002615
19 splenomegaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0001744
20 hepatomegaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0002240
21 vomiting 58 31 occasional (7.5%) Occasional (29-5%) HP:0002013
22 anemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001903
23 thrombocytopenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001873
24 jaundice 58 31 occasional (7.5%) Occasional (29-5%) HP:0000952
25 meningitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001287
26 petechiae 58 31 occasional (7.5%) Occasional (29-5%) HP:0000967
27 hyporeflexia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001265
28 cyanosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000961
29 diarrhea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002014
30 edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0000969
31 oliguria 58 31 occasional (7.5%) Occasional (29-5%) HP:0100520
32 decreased liver function 58 31 occasional (7.5%) Occasional (29-5%) HP:0001410
33 temperature instability 58 31 occasional (7.5%) Occasional (29-5%) HP:0005968
34 prenatal maternal abnormality 58 31 occasional (7.5%) Occasional (29-5%) HP:0002686
35 enterocolitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0004387
36 bradycardia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001662
37 decreased pulmonary function 58 31 occasional (7.5%) Occasional (29-5%) HP:0005952
38 abnormality of the anterior fontanelle 58 31 occasional (7.5%) Occasional (29-5%) HP:0000236
39 reversible renal failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0004713
40 nasal flaring 58 31 occasional (7.5%) Occasional (29-5%) HP:0030863
41 seizure 31 occasional (7.5%) HP:0001250
42 acute disseminated intravascular coagulation 58 31 very rare (1%) Very rare (<4-1%) HP:0011880
43 disseminated viral infection 58 31 very rare (1%) Very rare (<4-1%) HP:0031696
44 seizures 58 Occasional (29-5%)
45 abnormality of immune system physiology 58 Very frequent (99-80%)
46 dyspnea 58 Frequent (79-30%)
47 purpura 58 Occasional (29-5%)
48 decreased body weight 58 Frequent (79-30%)
49 abnormal bleeding 58 Occasional (29-5%)
50 functional abnormality of the gastrointestinal tract 58 Frequent (79-30%)

Drugs & Therapeutics for Sepsis in Premature Infants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase III, Randomized, Double-blind, Multi-center Clinical Trial Comparing the Safety and Efficacy of Veronate® Versus Placebo for the Prevention of Nosocomial Staphylococcal Sepsis in Premature Infants (Birth Weight 500 - 1250 g) Completed NCT00113191 Veronate

Search NIH Clinical Center for Sepsis in Premature Infants

Genetic Tests for Sepsis in Premature Infants

Anatomical Context for Sepsis in Premature Infants

MalaCards organs/tissues related to Sepsis in Premature Infants:

40
Bone, Liver, Lung, Thyroid

Publications for Sepsis in Premature Infants

Articles related to Sepsis in Premature Infants:

(show top 50) (show all 55)
# Title Authors PMID Year
1
Exposure to intrauterine inflammation and late-onset sepsis in very preterm infants. 61
33731804 2021
2
The Use of Daptomycin in the Treatment of Persistent Coagulase-Negative Staphylococcal Sepsis in Premature Infants: A Case Series. 61
33424506 2021
3
Early detection of late onset sepsis in premature infants using visibility graph analysis of heart rate variability. 61
32881699 2020
4
The effects of proton pump inhibitors on the microbiome in young children. 61
32027402 2020
5
Trajectories of the heart rate characteristics index, a physiomarker of sepsis in premature infants, predict Neonatal ICU mortality. 61
33240492 2020
6
Does antibiotic choice for the treatment of suspected late-onset sepsis in premature infants determine the risk of developing necrotising enterocolitis? A systematic review. 61
30025222 2018
7
The Role of a Single Dose of Vancomycin in Reducing Clinical Sepsis in Premature Infants Prior to Removal of Peripherally Inserted Central Catheter: A Retrospective Study. 61
29475199 2018
8
Management of pneumatosis intestinalis in children over the age of 6 months: a conservative approach. 61
28988213 2018
9
Adjuvant pretreatment with alum protects neonatal mice in sepsis through myeloid cell activation. 61
29052227 2018
10
Serum Interleukin-33 as a Biomarker in Predicting Neonatal Sepsis in Premature Infants. 61
30207217 2018
11
The role of interleukin-6 in the early diagnosis of sepsis in premature infants. 61
29081936 2017
12
Effects of cord blood vitamin D levels on the risk of neonatal sepsis in premature infants. 61
29042866 2017
13
Candida parapsilosis Protects Premature Intestinal Epithelial Cells from Invasion and Damage by Candida albicans. 61
28382297 2017
14
Fluconazole Prophylaxis for the Prevention of Candidiasis in Premature Infants: A Meta-analysis Using Patient-level Data. 61
27298330 2016
15
Determinants of Carboxyhemoglobin Levels and Relationship with Sepsis in a Retrospective Cohort of Preterm Neonates. 61
27552216 2016
16
[PREDICTIVE MODEL OF EARLY BACTERIAL INFECTIONS DEVELOPMENT IN PREMATURE INFANTS]. 61
26177138 2015
17
Pharmacokinetics of linezolid treatment using intravenous and oral administrations in extremely premature infants. 61
25740677 2015
18
Antibiotics Before Removal of Percutaneously Inserted Central Venous Catheters Reduces Clinical Sepsis in Premature Infants. 61
26170772 2015
19
The effect of topical ointment on neonatal sepsis in preterm infants. 61
24588277 2015
20
Resistin--a novel feature in the diagnosis of sepsis in premature neonates. 61
23147079 2013
21
Neonatal sepsis due to Rhodococcus equi in two preterm infants. 61
24192689 2013
22
Molecular detection of late-onset neonatal sepsis in premature infants using small blood volumes: proof-of-concept. 61
23485823 2013
23
Characteristics of Invasive Staphylococcus aureus in United Kingdom Neonatal Units. 61
21654546 2011
24
[Peripheral and central vascular catheter as risk for primary nosocomial sepsis in premature infants]. 61
21192467 2010
25
Sepsis-associated electroencephalographic changes in extremely low gestational age neonates. 61
20708356 2010
26
Risk factors and prevention of late-onset sepsis in premature infants. 61
20116186 2010
27
[Effects of probiotics on intestinal bacterial colonization in premature infants]. 61
20350428 2010
28
Vitamin D supplementation of mother and infant could reduce risk of sepsis in premature infants. 61
20188500 2010
29
[Measurement of the passive compliance of the total respiratory system in newborn after respiratory insufficiency for risk assessment of respiratory disorders during the first 6 month of life]. 61
20684334 2010
30
Comparison of serum amyloid A concentrations with those of C-reactive protein and procalcitonin in diagnosis and follow-up of neonatal sepsis in premature infants. 61
19078972 2009
31
Is urine interleukin-8 level a reliable laboratory test for diagnosing late onset sepsis in premature infants? 61
17596292 2007
32
Heart rate characteristics monitoring for neonatal sepsis. 61
16402612 2006
33
Multicenter study to determine antibody concentrations and assess the safety of administration of INH-A21, a donor-selected human Staphylococcal immune globulin, in low-birth-weight infants. 61
16189088 2005
34
Prevention of neonatal group B streptococcal disease: progress, challenges and dilemmas. 61
15569279 2004
35
The effect of neonatal sepsis on bone turnover in very-low birth weight premature infants. 61
12705367 2003
36
Effects of granulocyte colony-stimulating factor on hyperoxia-induced lung injury in newborn piglets. 61
12391513 2002
37
Improving the outcome of septic shock in children. 61
11964795 2000
38
Risk factors associated with early-onset sepsis in premature infants. 61
10584628 1999
39
Soluble interleukin-2 receptor as a predictor of neonatal sepsis. 61
7776112 1995
40
Intravenous immune globulin prophylaxis of late-onset sepsis in premature neonates. 61
7996367 1994
41
Pentoxifylline treatment of sepsis of premature infants: preliminary clinical observations. 61
7957428 1994
42
Opsonic antibodies to Staphylococcus epidermidis: in vitro and in vivo studies using human intravenous immune globulin. 61
8106765 1994
43
Trichosporon beigelii: a potential cause of sepsis in premature infants. 61
1470973 1992
44
Intravenous immunoglobulin for prophylaxis of neonatal sepsis in premature infants. 61
3284483 1988
45
[Use of the blood plasma of donors immunized with an enterobacterial vaccine in treating sepsis in premature infants]. 61
3380620 1988
46
[Blood lipid and phospholipid spectra in sepsis in premature infants]. 61
7220192 1981
47
[Cytochemical diagnosis of inflammatory diseases and sepsis in premature infants]. 61
1196785 1975
48
[Clinical aspects and some indices of nonspecific immunity in sepsis in premature infants]. 61
4422417 1974
49
[Clinico-morphological characteristics of the primary septic focus in umbilical sepsis in premature infants]. 61
4464640 1974
50
[Clinical aspects of sepsis in premature infants]. 61
4782729 1973

Variations for Sepsis in Premature Infants

Expression for Sepsis in Premature Infants

Search GEO for disease gene expression data for Sepsis in Premature Infants.

Pathways for Sepsis in Premature Infants

GO Terms for Sepsis in Premature Infants

Biological processes related to Sepsis in Premature Infants according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 8.62 CRP CALCA

Sources for Sepsis in Premature Infants

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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