MCID: SPT023
MIFTS: 33

Septate Uterus

Categories: Fetal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Septate Uterus

MalaCards integrated aliases for Septate Uterus:

Name: Septate Uterus 58

Classifications:

Orphanet: 58  
Rare infertility disorders
Rare gynaecological and obstetric diseases
Developmental anomalies during embryogenesis


External Ids:

ICD10 via Orphanet 33 Q51.2
UMLS via Orphanet 72 C0152240
Orphanet 58 ORPHA180122

Summaries for Septate Uterus

MalaCards based summary : Septate Uterus is related to placenta accreta and adenocarcinoma. An important gene associated with Septate Uterus is FLT1 (Fms Related Receptor Tyrosine Kinase 1), and among its related pathways/superpathways are MAPK signaling pathway and Ras signaling pathway. The drugs Hyaluronic acid and Adjuvants, Immunologic have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and placenta, and related phenotypes are Decreased cell migration and Synthetic lethal with gemcitabine

Wikipedia : 74 A uterine septum is a form of a congenital malformation where the uterine cavity is partitioned by a... more...

Related Diseases for Septate Uterus

Diseases related to Septate Uterus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 placenta accreta 29.9 KDR FLT1
2 adenocarcinoma 28.9 KDR FLT1
3 complete septate uterus 12.7
4 partial septate uterus 12.6
5 infertility 10.8
6 longitudinal vaginal septum 10.7
7 uterine anomalies 10.5
8 endometriosis 10.4
9 bicornuate uterus 10.4
10 renal hypodysplasia/aplasia 1 10.3
11 amenorrhea 10.3
12 suppressor of tumorigenicity 3 10.3
13 transverse vaginal septum 10.3
14 uterus bicornis bicollis with partial vaginal septum and unilateral hematocolpos with ipsilateral renal agenesis 10.2
15 cervical cancer 10.2
16 endometrial cancer 10.2
17 vaginal discharge 10.2
18 double uterus-hemivagina-renal agenesis 10.2
19 hydatidiform mole, recurrent, 1 10.0
20 mayer-rokitansky-kuster-hauser syndrome 10.0
21 adenomyosis 10.0
22 chromosome 16p13.3 deletion syndrome, proximal 10.0
23 leukemia, acute lymphoblastic 10.0
24 leukemia, acute lymphoblastic 3 10.0
25 tuberculous salpingitis 10.0
26 omphalocele 10.0
27 ectopic pregnancy 10.0
28 lymphocytic leukemia 10.0
29 placenta praevia 10.0
30 leiomyoma 10.0
31 adhesions of uterus 10.0
32 myoma 10.0
33 gestational trophoblastic neoplasm 10.0
34 cervical adenocarcinoma 10.0
35 salpingitis 10.0
36 appendicitis 10.0
37 placental abruption 10.0
38 cervical incompetence 10.0
39 hemometra 10.0
40 asherman's syndrome 10.0
41 paresthesia 10.0
42 multicystic dysplastic kidney 10.0
43 partial hydatidiform mole 10.0
44 vaginal atresia 10.0
45 renal dysplasia 10.0
46 angiokeratoma of mibelli 9.8 KDR FLT1
47 angiokeratoma circumscriptum 9.8 KDR FLT1
48 epithelioid hemangioendothelioma 9.8 KDR FLT1
49 primary cutaneous b-cell lymphoma 9.8 KDR FLT1
50 kuhnt-junius degeneration 9.8 KDR FLT1

Graphical network of the top 20 diseases related to Septate Uterus:



Diseases related to Septate Uterus

Symptoms & Phenotypes for Septate Uterus

GenomeRNAi Phenotypes related to Septate Uterus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 8.96 FLT1 KDR
2 Synthetic lethal with gemcitabine GR00225-A 8.62 FLT1 KDR

Drugs & Therapeutics for Septate Uterus

Drugs for Septate Uterus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
2 Adjuvants, Immunologic
3 Protective Agents
4 Viscosupplements
5 Immunologic Factors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Three Dimensional Trans-vaginal Ultrasound to Reevaluate Arcuate Uteri Diagnosed by Hystro-salpingography Completed NCT02597816 Phase 2
2 Prevention of Intrauterine Adhesions After Hysteroscopic Metroplasty With Autocross-linked Hyaluronic Acid Gel Unknown status NCT02404454
3 3D Ultrasound Uterine Characteristics of Women Undergoing IVF/ICSI Treatment Recruiting NCT02549235
4 Determining the Fertility Benefit of Immediate SO+IUI After Operative Laparoscopy in Patients With Advanced Stage Endometriosis Withdrawn NCT02520505 Supraovulation clomiphene citrate

Search NIH Clinical Center for Septate Uterus

Genetic Tests for Septate Uterus

Anatomical Context for Septate Uterus

MalaCards organs/tissues related to Septate Uterus:

40
Uterus, Cervix, Placenta, Ovary, Testes, Endothelial, Brain

Publications for Septate Uterus

Articles related to Septate Uterus:

(show top 50) (show all 422)
# Title Authors PMID Year
1
Proposal of the 3O (Obstruction, Ureteric Orifice, and Outcome) Subclassification System Associated with Obstructed Hemivagina and Ipsilateral Renal Anomaly (OHVIRA). 61
31931122 2020
2
Operative hysteroscopy-assisted pregnancy termination after failed surgical abortion in missed abortion of woman with complete septate uterus. 61
31970135 2020
3
Septate uterus according to ESHRE/ESGE, ASRM and CUME definitions: association with infertility and miscarriage, cost and warnings for women and healthcare systems. 61
30977223 2019
4
Reproductive outcome of a complete septate uterus after hysteroscopic metroplasty. 61
31854214 2019
5
Antenatal Presentation of Wilms' Tumor. 61
31421145 2019
6
Reproductive Implications and Management of Congenital Uterine Anomalies: Scientific Impact Paper No. 62 November 2019. 61
31749334 2019
7
Uterine anomalies and endometriosis: an overview. 61
31755672 2019
8
Müllerian Anomalies Prevalence Diagnosed by Hysteroscopy and Laparoscopy in Mexican Infertile Women: Results from a Cohort Study. 61
31627332 2019
9
The pathophysiology of the septate uterus: a systematic review. 61
31004459 2019
10
The pathophysiology of septate uterus. 61
31173458 2019
11
Currarino syndrome in an adult woman. 61
31538082 2019
12
Overdiagnosis, overdetection, and overdefinition of the septate uterus: reexamination of the ASRM and ESHRE-ESGE criteria is urgently needed. 61
31371057 2019
13
Fetal arthrogryposis multiplex congenita/fetal akinesia deformation sequence (FADS)-Aetiology, diagnosis, and management. 61
31218730 2019
14
Is hysteroscopic metroplasty using the incision method for septate uterus a risk factor for adverse obstetric outcomes? 61
30656791 2019
15
Three-dimensional ultrasound in the diagnosis and the classification of congenital uterine anomalies using the ESHRE/ESGE classification: a diagnostic accuracy study. 61
30661094 2019
16
Frequency and types of uterine anomalies during caesarean section. 61
30372654 2019
17
Hysteroscopic Corrections for Complete Septate and T-Shaped Uteri Have Similar Surgical and Reproductive Outcome. 61
29402197 2018
18
Hysteroscopic septum resection and reproductive medicine: A SWOT analysis. 61
30527061 2018
19
An unusual case of Herlyn-Werner-Wunderlich syndrome with a complete septate uterus and complicated urinary tract with rare ectopic ureteral opening. 61
29959772 2018
20
Surgical treatment of septate uterus in cases of primary infertility and before assisted reproductive technologies. 61
30149207 2018
21
ESHRE-ESGE versus ASRM classification in the diagnosis of septate uterus: a retrospective study. 61
30159673 2018
22
Three-dimensional scan of the uterine cavity of infertile women before assisted reproductive technology use. 61
30313087 2018
23
The randomised uterine septum transsection trial (TRUST): design and protocol. 61
30290803 2018
24
Using 3D MRI can potentially enhance the ability of trained surgeons to more precisely diagnose Mullerian duct anomalies compared to MR alone. 61
30075412 2018
25
Small-Diameter Hysteroscopic Metroplasty for a Septate Uterus after Open-Assisted Laparoscopic Radical Trachelectomy. 61
29146391 2018
26
Pre-, intra-, and postoperative management of Robert's uterus. 61
30196976 2018
27
Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome with septic shock: A case report. 61
29978541 2018
28
Assessment of hysteroscopic role in management of women with recurrent pregnancy loss. 61
28412850 2018
29
Are 3D ultrasound and office hysteroscopy useful for the assessment of uterine cavity after late foetal loss? 61
29475047 2018
30
Brachytherapy for cervical cancer in septate uterus: Dose-volume differences with tandem implant placement in right vs. left uterine canal: A case report. 61
29725444 2018
31
ESHRE/ESGE female genital tract anomalies classification system-the potential impact of discarding arcuate uterus on clinical practice. 61
29514262 2018
32
[Diagnosis accuracy of endoscopy (laparoscopy, hysteroscopy, fertiloscopy, cystoscopy, colonoscopy) in case of endometriosis: CNGOF-HAS Endometriosis Guidelines]. 61
29530560 2018
33
New Ambulatory Hysteroscopic Septoplasty using Ballooning in a Woman with Complete Septate Uterus: A Case Report. 61
29707689 2018
34
Septate Uterus in a Girl with Rubinstein-Taybi Syndrome. 61
29850348 2018
35
A Rare Uterine Malformation: Asymmetric Septate Uterus. 61
28647574 2018
36
Uterus Septus Subtotalis Bicollis: A Rare Mullerian Duct Abnormality. 61
29531007 2018
37
Vaginal atresia and cervical agenesis combined with asymmetric septate uterus: A case report of a new genital malformation and literature review. 61
29505013 2018
38
Congenital Uterine Malformation by Experts (CUME): better criteria for distinguishing between normal/arcuate and septate uterus? 61
29024135 2018
39
A novel mutation of HOXA11 in a patient with septate uterus. 61
29229001 2017
40
The spectrum of imaging appearances of müllerian duct anomalies: focus on MR imaging. 61
28921452 2017
41
Martius' flap for recurrent perineal and rectovaginal fistulae in a patient with Crohn's disease, endometriosis and a mullerian anomaly. 61
29162069 2017
42
Locally advanced squamous cell cervical cancer in a patient with septate uterus. 61
29204170 2017
43
Pregnancy Complications After Hysteroscopic Metroplasty: A Ten-Year Case-Control Study. 61
28277599 2017
44
Abnormal ultrasound appearance of the amniotic membranes - diagnostic and significance: a pictorial essay. 61
28440356 2017
45
Endometrial cancer with congenital uterine anomalies: 3 case reports and a literature review. 61
28118070 2017
46
Management of cervical dysplasia in patient with Müllerian anomaly: diagnostic and therapeutic challenges. 61
29693895 2017
47
Uterine Cavity Abnormalities in Patients with Endometriosis in Alexandria: A Diagnostic Test Accuracy Study. 61
28638413 2017
48
Magnetic Resonance Imaging (MRI) Depiction of Robert's Uterus: A Rare Müllerian Duct Anomaly Presenting with Cyclical Pain in Young Menstruating Woman. 61
28348653 2017
49
Septum resection for women of reproductive age with a septate uterus. 61
28093720 2017
50
Do the types of treatments after hysteroscopic resection of septate uterus cause different results? 61
29746048 2017

Variations for Septate Uterus

Expression for Septate Uterus

Search GEO for disease gene expression data for Septate Uterus.

Pathways for Septate Uterus

Pathways related to Septate Uterus according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1 12.27 KDR FLT1
2
Show member pathways
12.24 KDR FLT1
3
Show member pathways
12.2 KDR FLT1
4
Show member pathways
12.01 KDR FLT1
5
Show member pathways
11.96 KDR FLT1
6
Show member pathways
11.94 KDR FLT1
7
Show member pathways
11.9 KDR FLT1
8
Show member pathways
11.79 KDR FLT1
9
Show member pathways
11.77 KDR FLT1
10
Show member pathways
11.74 KDR FLT1
11 11.65 KDR FLT1
12
Show member pathways
11.52 KDR FLT1
13
Show member pathways
11.4 KDR FLT1
14 11.35 KDR FLT1
15
Show member pathways
11.29 KDR FLT1
16 11.23 KDR FLT1
17 10.96 KDR FLT1
18
Show member pathways
10.79 KDR FLT1
19 10.69 KDR FLT1
20 10.34 KDR FLT1
21
Show member pathways
9.83 KDR FLT1

GO Terms for Septate Uterus

Cellular components related to Septate Uterus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.62 KDR FLT1

Biological processes related to Septate Uterus according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.52 KDR FLT1
2 angiogenesis GO:0001525 9.51 KDR FLT1
3 cell migration GO:0016477 9.49 KDR FLT1
4 protein autophosphorylation GO:0046777 9.48 KDR FLT1
5 positive regulation of angiogenesis GO:0045766 9.46 KDR FLT1
6 peptidyl-tyrosine phosphorylation GO:0018108 9.43 KDR FLT1
7 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.4 KDR FLT1
8 positive regulation of MAPK cascade GO:0043410 9.37 KDR FLT1
9 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.32 KDR FLT1
10 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.26 KDR FLT1
11 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.16 KDR FLT1
12 sprouting angiogenesis GO:0002040 8.96 KDR FLT1
13 vascular endothelial growth factor signaling pathway GO:0038084 8.62 KDR FLT1

Molecular functions related to Septate Uterus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.32 KDR FLT1
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.26 KDR FLT1
3 growth factor binding GO:0019838 9.16 KDR FLT1
4 vascular endothelial growth factor binding GO:0038085 8.96 KDR FLT1
5 vascular endothelial growth factor-activated receptor activity GO:0005021 8.62 KDR FLT1

Sources for Septate Uterus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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