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MCID: SPT004
MIFTS: 58

Septic Arthritis

Categories: Blood diseases, Bone diseases, Infectious diseases, Nephrological diseases, Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Septic Arthritis

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MalaCards integrated aliases for Septic Arthritis:

Name: Septic Arthritis 12 20 15
Infectious Arthritis 12 74 20 42 17
Arthritis, Infectious 44 71
Arthritis, Bacterial 71
Arthritis Septic 54

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Bone diseases Reproductive diseases Nephrological diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:813
MeSH 44 D001170
NCIt 50 C26700
ICD10 32 M00
UMLS 71 C0003869 C0157843 C0157844 more
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Summaries for Septic Arthritis

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MedlinePlus : 42 Most kinds of arthritis cause pain and swelling in your joints. Joints are places where two bones meet, such as your elbow or knee. Infectious arthritis is an infection in the joint. The infection comes from a bacterial, viral, or fungal infection that spreads from another part of the body. Symptoms of infectious arthritis include Intense pain in the joint Joint redness and swelling Chills and fever Inability to move the area with the infected joint One type of infectious arthritis is reactive arthritis. The reaction is to an infection somewhere else in your body. The joint is usually the knee, ankle, or toe. Sometimes, reactive arthritis is set off by an infection in the bladder, or in the urethra, which carries urine out of the body. In women, an infection in the vagina can cause the reaction. For both men and women, it can start with bacteria passed on during sex. Another form of reactive arthritis starts with eating food or handling something that has bacteria on it. To diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. Treatment includes medicines and sometimes surgery.

MalaCards based summary : Septic Arthritis, also known as infectious arthritis, is related to haemophilus influenzae and osteomyelitis, and has symptoms including fever, back pain and pruritus. An important gene associated with Septic Arthritis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Amoxicillin and Clavulanate have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and bone marrow, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An arthritis that involves infection by a pathogen located in joint.

GARD : 20 Infectious arthritis is joint pain, soreness, stiffness and swelling caused by a bacterial, viral, or fungal infection that spreads from another part of the body. Depending on the type of infection, one or more joints may be affected. Certain bacteria can cause a form of infectious arthritis called reactive arthritis, which appears to be caused by the immune system reacting to bacteria, rather than by the infection itself. In reactive arthritis, joint inflammation develops weeks, months or even years after the infection. Reactive arthritis happens most commonly after infections of the genital and gastrointestinal tracts. To diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. Treatment includes medicines and sometimes surgery.

Wikipedia : 74 Septic arthritis, also known as joint infection or infectious arthritis, is the invasion of a joint by... more...

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Related Diseases for Septic Arthritis

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Diseases related to Septic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 587)
# Related Disease Score Top Affiliating Genes
1 haemophilus influenzae 31.5 TLR2 CXCL8
2 osteomyelitis 31.5 TLR4 TLR2 IFNG CXCL8 CRP CALCA
3 arthritis 31.4 TLR4 TLR2 MMP7 MMP3 MMP1 IFNG
4 synovitis 31.4 MMP3 MMP1 CXCL8 CRP
5 endocarditis 31.3 TLR2 IFNG CXCL8 CRP
6 infective endocarditis 31.2 TREM1 TLR2 CRP
7 prosthetic joint infection 31.2 TLR4 TLR2 CRP
8 mycobacterium kansasii 31.0 TLR2 CXCL8
9 urinary tract infection 31.0 TLR4 CRP
10 mycobacterium marinum 31.0 TLR2 CXCL8
11 arthropathy 30.9 MMP3 MMP2 MMP1 IFNG CRP
12 exanthem 30.9 IFNG CXCL8 CRP
13 toxic shock syndrome 30.9 TREM1 TLR4 TLR2 IFNG CXCL8 CRP
14 bursitis 30.8 MMP3 CRP CALCA
15 discitis 30.8 CRP CALCA
16 lyme disease 30.8 TLR9 TLR2 CRP
17 osteoarthritis 30.8 MMP3 MMP1 CXCL8 CRP
18 endophthalmitis 30.7 TLR2 CXCL8 CRP
19 brucellosis 30.7 TLR4 IFNG CXCL8 CRP
20 otitis media 30.7 TLR4 TLR2 IFNG CXCL8 CRP
21 reactive arthritis 30.7 TLR4 TLR2 IFNG CXCL8 CRP
22 enterocolitis 30.6 TLR4 CXCL8 CRP
23 spondyloarthropathy 1 30.6 TLR4 MMP3 CRP
24 fasciitis 30.6 MMP1 IFNG CXCL8
25 melioidosis 30.6 TREM1 TLR5 TLR4 TLR2 IFNG
26 disease by infectious agent 30.6 TLR9 TLR4 TLR2 IFNG DEFB4A CRP
27 peritonitis 30.5 TLR4 TLR2 CXCL8 CRP
28 nocardiosis 30.5 IFNG CRP
29 pericarditis 30.5 IFNG CXCL8 CRP
30 typhoid fever 30.5 TLR5 TLR4 IFNG CRP
31 acne 30.5 TLR2 MMP2 DEFB4A CXCL8
32 sarcoidosis 1 30.5 IFNG CXCR3 CRP CCL18
33 klebsiella pneumonia 30.5 TLR4 TLR2 CXCL8 CRP
34 acute cystitis 30.4 TLR4 CXCL8 CRP
35 granulomatosis with polyangiitis 30.4 TLR9 TLR4 TLR2 CRP
36 streptococcus pneumonia 30.4 TLR9 TLR4 TLR2 CXCL8 CRP
37 meningitis 30.4 TLR9 TLR4 TLR2 IFNG CXCL8 CRP
38 mycobacterium chelonae 30.4 TLR2 CXCL8
39 appendicitis 30.4 TLR4 IFNG CXCL8 CRP
40 familial mediterranean fever 30.3 TLR4 TLR2 CXCL8 CRP
41 bone inflammation disease 30.3 TLR4 TLR2 MMP3 MMP1 IFNG CXCL8
42 mycobacterium abscessus 30.3 TLR2 CXCL8
43 acute pyelonephritis 30.3 CXCL8 CRP CALCA
44 chorioamnionitis 30.3 TREM1 TLR4 CXCL8 CRP
45 conjunctivitis 30.3 TLR3 IFNG CXCL8
46 gastroenteritis 30.3 TLR9 IFNG CXCL8 CRP CALCA
47 salmonellosis 30.2 TLR5 TLR4 TLR2 IFNG DEFB4A CXCL8
48 cholangitis 30.2 TLR4 CXCL8 CRP
49 connective tissue disease 30.2 MMP3 IFNG CXCL8 CRP CALCA
50 meningococcal meningitis 30.2 TLR9 TLR4 TLR2

Comorbidity relations with Septic Arthritis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Septic Arthritis:



Diseases related to Septic Arthritis
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Symptoms & Phenotypes for Septic Arthritis

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UMLS symptoms related to Septic Arthritis:


fever, back pain, pruritus, sciatica, muscle cramp

MGI Mouse Phenotypes related to Septic Arthritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 CXCR3 IFNG ITGA2 MMP2 MMP3 MMP7
2 homeostasis/metabolism MP:0005376 10.13 CRP CXCR3 IFNG ITGA2 MMP1 MMP2
3 immune system MP:0005387 10 CRP CXCR3 IFNG MMP1 MMP2 MMP3
4 neoplasm MP:0002006 9.61 CXCR3 IFNG MMP1 MMP2 MMP7 TLR2
5 respiratory system MP:0005388 9.23 CXCR3 IFNG MMP2 RELA TLR2 TLR3
Sources

Drugs & Therapeutics for Septic Arthritis

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Drugs for Septic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
2
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
3
Dicloxacillin Approved, Investigational, Vet_approved Phase 4 3116-76-5 18381
4
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
5
Nafcillin Approved, Investigational Phase 4 147-52-4, 985-16-0 8982
6
Cloxacillin Approved, Investigational, Vet_approved Phase 4 61-72-3 6098
7
Fosfomycin Approved Phase 4 23155-02-4 446987
8
Dalbavancin Approved, Investigational Phase 4 171500-79-1, 91097-81-3 122186
9
Cefazolin Approved Phase 4 25953-19-9 656510 33255
10
Cephalexin Approved, Investigational, Vet_approved Phase 4 15686-71-2 27447
11
Vancomycin Approved Phase 4 1404-90-6 441141 14969
12
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
13
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
14 Coagulase Phase 4
15 Amoxicillin-Potassium Clavulanate Combination Phase 4
16 beta-Lactamase Inhibitors Phase 4
17
Tedizolid Approved, Investigational Phase 2 856866-72-3
18
Tedizolid phosphate Approved Phase 2 856867-55-5
19
Rifampicin Approved Phase 2 13292-46-1 5458213 5381226
20
Ofloxacin Approved Phase 2 82419-36-1 4583
21
Levofloxacin Approved, Investigational Phase 2 100986-85-4 149096
22
Sulfamethoxazole Approved Phase 2 723-46-6 5329
23
Ciprofloxacin Approved, Investigational Phase 2 85721-33-1 2764
24
Trimethoprim Approved, Vet_approved Phase 2 738-70-5 5578
25
Oxacillin Approved, Investigational Phase 2 66-79-5 6196
26 Oxazolidinones Phase 2
27 Cytochrome P-450 Enzyme Inhibitors Phase 2
28 Antiprotozoal Agents Phase 2
29 Antiparasitic Agents Phase 2
30 Trimethoprim, Sulfamethoxazole Drug Combination Phase 2
31 Antimalarials Phase 2
32
Salmon calcitonin Approved, Investigational 47931-85-1 16129616
33
Denosumab Approved 615258-40-7
34
Cefepime Approved, Investigational 88040-23-7 5479537
35
Tazobactam Approved 89786-04-9 123630
36
Piperacillin Approved 66258-76-2 43672
37
Cefotaxime Approved 63527-52-6 456256 5742673
38
Cefoxitin Approved 35607-66-0 441199
39
Acetaminophen Approved 103-90-2 1983
40
Teicoplanin Approved, Investigational 61036-62-2
41
Levoleucovorin Approved, Investigational 68538-85-2 149436
42
Minocycline Approved, Investigational 10118-90-8 5281021
43
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
44
Clindamycin Approved, Vet_approved 18323-44-9 29029
45
Fusidic Acid Approved, Investigational 6990-06-3 3000226
46
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
47
Calcitonin gene-related peptide Investigational 83652-28-2
48
Pristinamycin Experimental, Investigational 270076-60-3
49 calcitonin
50 Katacalcin

Interventional clinical trials:

(show top 50) (show all 81)
# Name Status NCT ID Phase Drugs
1 Randomized Open Label Study of Oral Versus Intravenous Antibiotic Treatment for Bone and Joint Infections Requiring Prolonged Antibiotic Treatment: Multi-centre Study Completed NCT00974493 Phase 4 Antibiotics
2 Oral-only Antibiotics for Bone and Joint Infections in Children - A Nationwide Randomized Controlled Trial Recruiting NCT04563325 Phase 4 Oral co-amoxiclav or oral dicloxacillin only;IV ceftriaxon followed by oral co-amoxiclav or oral dicloxacillin
3 Ceftriaxone as Home Intravenous Therapy for Deep-Seated Staphylococcal Infections, a Randomized Non-Inferiority Trial Recruiting NCT04141787 Phase 4 Ceftriaxone;Usual Antibiotics (Cloxacillin, Cefazolin, Daptomycin)
4 Efficacy and Safety of Intravenous Fosfomycin in Prosthetic Joint Infection (PJI) Caused by Staphylococci, Streptococci, Enterococci and Gram-negative Bacilli, Including Mixed Infections and Culture Negative PJI's ("PROOF-Study") Recruiting NCT03260010 Phase 4 Fosfomycin
5 Dalbavancin For The Treatment Of Gram Positive Osteomyelitis Or Joint Infections Including Prosthetic Hip Or Knee Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
6 BonE and Joint Infections - Simplifying Treatment in Children Trial Not yet recruiting NCT04538053 Phase 4 Oral cefalexin only;IV cefazolin followed by oral cefalexin
7 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
8 Ceftaroline in the Treatment of Bone and Joint Infections Withdrawn NCT02005068 Phase 4 Ceftaroline
9 An Open-Label, Non-Randomized, Single-Arm, Multi-Center Study to Evaluate Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections in Subjects for Whom Chronic Antibiotic Suppressive Therapy is Indicated Completed NCT02569541 Phase 2, Phase 3 sodium fusidate
10 Arthrotomy With Irrigation and Debridement Versus Serial Arthrocentesis as Treatment for Septic Arthritis in Adults Withdrawn NCT00313365 Phase 3
11 Tolerability, Safety, and Efficacy of Tedizolid as Oral Treatment for Bone and Joint Infections Recruiting NCT03009045 Phase 2 Tedizolid
12 Randomized Open-label Active-controlled Study to Assess the Safety, Tolerability, and Efficacy of Afabicin IV/Oral in the Treatment of Patients With Bone or Joint Infection Due to Staphylococcus Active, not recruiting NCT03723551 Phase 2 Afabicin (Part A);Standard of Care;Afabicin (Part B)
13 Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection Terminated NCT01756924 Phase 2 CEM-102;IV or Oral standard of care antibiotics;Rifampin
14 Comparative Pharmacokinetics and Pharmacodynamics (PK/PD) of Cefadroxil and Cephalexin for Pediatric Musculoskeletal (MSK) Infections Enrolling by invitation NCT03802552 Phase 1 Cefadroxil;Cephalexin
15 Early Diagnostics of Septic Arthritis and Periprosthetic Joint Infections With Calorimetry and Polymerase Chain Reaction (PCR) of Synovial Aspirate Fluid Unknown status NCT02530229
16 Causative Diagnosis on Prosthetic Joint Infections: Establishment of a Comprehensive Diagnostic Strategy Unknown status NCT01957228
17 Efficacy and Safety of Fast-track Treatment for Prosthetic Joint Infection (PJI) Unknown status NCT02372435
18 The Utility of Next-generation Sequencing for the Diagnosis of Periprosthetic Joint Infection Unknown status NCT03200470
19 Benefit of Synovial Aspiration and Serological Testing in Two-stage Revision Arthroplasty of Prosthetic Joint Infection Unknown status NCT03038464
20 Two Versus Four Weeks of Antibiotic Treatment in Native Joint Arthritis Completed NCT03615781 Two week's arm - drugs;Four week's arm - drugs
21 Pro-calcitonin for Early Detection of Septic Arthritis Completed NCT02085733
22 Ultrasonography Assessment of Septic Arthritis on Native Joint: a Descriptive, Exploratory, Prospective, Multicentric Trial Completed NCT02018952
23 ARTEMIS Synovial Markers in Arthritis Childhood Completed NCT02505828
24 Use of Infrared Spectroscopy in Septic Arthritis Diagnosis Completed NCT02860871
25 Experience of Workforce From Orthopaedic and Spine Center Ghurki Trust Hospital Pakistan During COVID-19 Completed NCT04516824
26 Clindamycin-Rifampin Interactions: Effect of Rifampin's Enzyme-induction (Cytochrome P450 3A4/3A5) on Plasma Clindamycin Concentrations, With Clindamycin Given Intravenously and Orally to Treat Bone-and-joint Infections Completed NCT02629770 usual antibiotic treatment
27 Personalized Immunotherapeutic for Antibiotic-resistant Infection Completed NCT02508584 Early Phase 1
28 Denosumab Related Osteonecrossi of the Jaw : : an Emergent and Potentially Complex Bone and Joint Infection Completed NCT03808285
29 A Retrospective, Blinded Validation Study to Assess the Accuracy of a Host-response Based Diagnostics for Distinguishing Between Bacterial and Viral Etiologies in Pediatric Patients With an Acute Febrile Disease Completed NCT01911143
30 Prolonged Oral Levofloxacin-Rifampin for Staphylococcus Aureus Prosthetic Joint Infection (PJI) Treated With Debridement And Retention Of Components: A Prospective Observational Cohort Study. Mayo PJI Study Group (MPSG)* Completed NCT00279864
31 Necrotizing External Otitis : Study in a Regional Bone and Joint Infection Completed NCT03768635
32 LOOP- Long- and Midterm Outcomes of Osteoarticular Infections in Paediatric Patients. Completed NCT03827980
33 Bacteriological Setting Before Prosthesis Implantation With One Stage Surgery in Prosthetic Joint Infection Completed NCT02806063
34 One-stage Exchange Arthroplasty for Chronic Prosthetic Joint Infections Completed NCT03473392
35 Procalcitonin Level as a Prognostic Marker and Its' Kinetics in Children With Bacterial Infections Completed NCT00714402
36 The Influence of Antibiotic Prophylaxis on Intraoperative Prosthetic Joint Infection Cultures Completed NCT02413034 Cefazolin
37 InterventiOnal Study of Bone and Joint Infections Related Gut dysbiosIS Completed NCT03011502
38 Daptomycin > 6 mg/kg/Day as Salvage Therapy in Patients With Complex Bone and Joint Infection: Cohort Study in a Regionalreference Center Completed NCT03209934
39 Implant-Associated P. Aeruginosa Bone And Joint Infections : Experience In A Regional Reference Center In France Completed NCT03624855
40 Comparison of the Tolerance of Vancomycin in Combination With Piperacillin/Tazobactam or Cefepim as Empirical Antimicrobial Therapy of Prosthetic Joint Infection Completed NCT03850860
41 Evaluation of the Use of Cefoxitin in Combination in Continuous Parenteral Administration in the Treatment of Bone and Joint Infections Completed NCT03848104
42 Pharmacokinetic Variability of Daptomycin During Prolonged Therapy for Bone and Joint Infections Completed NCT03209921
43 Pristinamycin in the Treatment of MSSA Bone and Joint Infection Completed NCT03177343
44 Microbiological Epidemiology in Patients Experiencing Microbiological or Clinical Failure Following Reimplantation After a 2-stage Exchange Strategy for Hip or Knee Prosthetic Joint Infection Completed NCT03627000
45 Subcutaneous Suppressive Antibiotic Therapy for Bone and Joint Infections Completed NCT03403608
46 Bacterial Epidemiology and Empirical Antibiotherapy in Patients With Prosthetic Joint Infection Completed NCT03191292
47 Teicoplanin-based Antimicrobial Therapy in Staphylococcus Aureus Bone and Joint Infection: Tolerance, Efficacy and Experience With Subcutaneous Administration Completed NCT03177369
48 Rapid Diagnosis of Prosthetic Joint Infection by Matrix-assisted Laser Desorption Ionization Time-of-flight Mass Spectrometry Completed NCT03717090
49 Cost of Failure Following Reimplantation After a 2-stage Exchange Strategy for Hip or Knee Prosthetic Joint Infection Completed NCT03612076
50 Short 3-week Antibiotic Treatment Versus 6 Weeks in Adults With Septic Arthritis of Native Joint: a Randomized, Open Label, Non-inferiority Trial Recruiting NCT03716921

Search NIH Clinical Center for Septic Arthritis

Cochrane evidence based reviews: arthritis, infectious

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Genetic Tests for Septic Arthritis

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Anatomical Context for Septic Arthritis

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The Foundational Model of Anatomy Ontology organs/tissues related to Septic Arthritis:

19
Joint

MalaCards organs/tissues related to Septic Arthritis:

40
Bone, Bone Marrow, Spinal Cord, Neutrophil, Skin, Myeloid, Colon
Sources

Publications for Septic Arthritis

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Articles related to Septic Arthritis:

(show top 50) (show all 6148)
# Title Authors PMID Year
1
Septic arthritis: a 5-year review of admissions to the Orthopedic Department. 42 61
33420773 2020
2
Optimizing culture methods according to preoperative mNGS results can improve joint infection diagnosis. 42
33380187 2021
3
Infographic: The EBJIS definition of periprosthetic joint infection. 42
33380197 2021
4
Serum procalcitonin for discrimination between septic and non-septic arthritis. 54 61
18578968 2008
5
Septic arthritis due to extended spectrum beta lactamase producing Klebsiella pneumoniae. 54 61
17433752 2007
6
Test characteristics of C-reactive protein (CRP) for pediatric septic arthritis. 61 54
15105739 2004
7
Assessment of the test characteristics of C-reactive protein for septic arthritis in children. 54 61
12724603 2003
8
Acute septic arthritis of the hip in children in northern Australia. 61 54
12608977 2003
9
Evaluation of leukergy test as an indicator of infection in hip joint in children. 61 54
11218681 2000
10
The painful hip: evaluation of criteria for clinical decision-making. 61 54
10541950 1999
11
Bacterial or crystal-associated arthritis? Discriminating ability of serum inflammatory markers. 61 54
10225388 1998
12
A collagen receptor on Staphylococcus aureus strains isolated from patients with septic arthritis mediates adhesion to cartilage. 61 54
8382334 1993
13
Risk Factors for Failure and Optimal Treatment of Total Joint Arthroplasty for Septic Arthritis. 61
33059964 2021
14
Primary Septic Arthritis Among Children 6 to 48 Months of Age: Implications for PCR Acquisition and Empiric Antimicrobial Selection. 61
33417393 2021
15
Current Concepts in Pediatric Septic Arthritis. 61
33273402 2021
16
Assessment of synovial fluid and serum cytokine levels in children with septic arthritis. 61
33579676 2021
17
Bacteria and Host Interplay in Staphylococcus aureus Septic Arthritis and Sepsis. 61
33546401 2021
18
Arthroscopic treatment of Mycobacterium massiliense septic arthritis outbreak after intra-articular injection: A case-series report and literature review. 61
33592840 2021
19
An uncommon case of native joint septic arthritis by Parvimonas micra. 61
33348083 2021
20
Brucella Septic Hip Arthritis: A Case Report. 61
33602891 2021
21
An automated real-time PCR assay for synovial fluid improves the preoperative etiological diagnosis of periprosthetic joint infection and septic arthritis. 61
33331672 2021
22
Kingella kingae Intrauterine Infection: An Unusual Cause of Chorioamnionitis and Miscarriage in a Patient with Undifferentiated Connective Tissue Disease. 61
33557386 2021
23
A 19-year-old farmer presented with acute hepatitis and deep vein thrombosis before being diagnosed as MRSA induced septic knee arthritis. 61
33551346 2021
24
Opportunities for Stewardship in the Transition From Intravenous to Enteral Antibiotics in Hospitalized Pediatric Patients. 61
33496660 2021
25
Anacardic acid-mediated regulation of osteoblast differentiation involves mitigation of inflammasome activation pathways. 61
33090336 2021
26
Pain for Greater Than 4 Days Is Highly Predictive of Concomitant Osteomyelitis in Children With Septic Arthritis. 61
33577239 2021
27
Improving Care and Outcomes for Pediatric Musculoskeletal Infections. 61
33414235 2021
28
A systematic review of the optimal drainage technique for septic hip arthritis in children. 61
33566696 2021
29
Shortened derivatives from native antimicrobial peptide LyeTx I: In vitro and in vivo biological activity assessment. 61
33175610 2021
30
Association between high vancomycin minimum inhibitory concentration and clinical outcomes in patients with methicillin-resistant Staphylococcus aureus bacteraemia - A retrospective cohort study. 61
33609261 2021
31
Susceptibility of canine chondrocytes and synoviocytes to antibiotic cytotoxicity in vitro. 61
33606293 2021
32
Genomic Characterization of a New Biofilm-Forming and Adhesive ST398 Human-Adapted MSSA Lineage Causing Septic Knee Arthritis Following Surgical Reconstruction. 61
33540689 2021
33
Distant metastatic foci of infection in adult patients with diabetic foot - not as rare as we think?: case series and review of the literature. 61
33423592 2021
34
A rare case of extensive Staphylococcus aureus sternoclavicular septic arthritis treated without surgical intervention. 61
33364169 2021
35
Re: Medical and conservative surgical management of bacterial sternoclavicular joint septic arthritis: a case series. 61
33590627 2021
36
Risk Factors, Screening, and Treatment Challenges in Staphylococcus aureus Native Septic Arthritis. 61
33511230 2021
37
111In-Oxine-WBC SPECT/CT of Lumbosacral Facet Joint Septic Arthritis. 61
32956115 2021
38
Rothia mucilaginosa: a case of septic arthritis in a native knee and review of the literature. 61
33462004 2021
39
A case of enteropathic arthritis complicated by superimposed bilateral septic arthritis of the hips. 61
33238804 2021
40
A rare case of septic arthritis of the knee caused by Salmonella typhi with preexisting typhoid fever in a healthy, immunocompetent child - A case report. 61
33316609 2021
41
A case of hip joint septic arthritis due to haematogenous infection, which was misdiagnosed sternoclavicular joint septic arthritis as SAPHO syndrome. 61
33427583 2021
42
Enterobacter cloacae infection of the shoulder in a 52-year-old woman without apparent predisposing risk factor: a case report and literature review. 61
33407223 2021
43
Machine-learning algorithm that can improve the diagnostic accuracy of septic arthritis of the knee. 61
33452576 2021
44
Long-term sequelae of septic arthritis after tibial plateau fracture fixation: does timing matter? 61
33417025 2021
45
Clostridium paraputrificum: An atypical and rare case of septic arthritis mimicking an acute sickle cell crisis. 61
33384929 2021
46
A narrative review of the last decade's literature on the diagnostic accuracy of septic arthritis of the native joint. 61
33423115 2021
47
Intracapsular pressure in children with septic arthritis of the hip. 61
32301824 2021
48
The Utility of Leukocyte Esterase Strip Test in the Diagnosis of Pediatric Septic Arthritis. 61
32852365 2021
49
Arthrotomy debridement of arthrostic septic arthritis of the knee is more effective than arthroscopic debridement and delays the need for prosthesis despite progression. 61
32591329 2021
50
Synovial fluid presepsin as a novel biomarker for the rapid differential diagnosis of native joint septic arthritis from crystal arthritis. 61
33278715 2021
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Variations for Septic Arthritis

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Expression for Septic Arthritis

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Search GEO for disease gene expression data for Septic Arthritis.
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Pathways for Septic Arthritis

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Pathways related to Septic Arthritis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.01 TREM1 TLR9 TLR5 TLR4 TLR3 TLR2
2
Integrin Pathway 63
Show member pathways
 13.4 MMP7 MMP3 MMP2 MMP1 ITGA2 CXCR3
3
Akt Signaling 63
Show member pathways
 13.4 TLR9 TLR5 TLR4 TLR3 TLR2 ITGA2
4
IL-2 Pathway 63
Show member pathways
 13.22 TREM1 TLR9 TLR5 TLR4 TLR3 TLR2
5
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.02 TREM1 TLR9 TLR5 TLR4 TLR3 TLR2
6
Pathways in cancer 36
12.84 RELA MMP2 MMP1 ITGA2 IFNG CXCL8
7
Measles 36
Show member pathways
 12.84 TLR9 TLR4 TLR3 TLR2 RELA IFNG
8
Herpes simplex virus 1 infection 36
12.8 TLR9 TLR3 TLR2 RELA IFNG
9
Degradation of the extracellular matrix 65
Show member pathways
 12.75 MMP7 MMP3 MMP2 MMP1 ITGA2
10
Salmonella infection (KEGG) 36
Show member pathways
 12.75 TLR9 TLR5 TLR4 TLR2 RELA CXCL8
11
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.75 TLR9 TLR5 TLR4 TLR3 TLR2 RELA
12
NF-KappaB Family Pathway 63
Show member pathways
 12.71 TLR9 TLR5 TLR4 TLR3 TLR2 RELA
13
T cell receptor signaling pathway 36
Show member pathways
 12.61 TLR9 TLR4 TLR2 RELA IFNG
14
Th17 cell differentiation 36
Show member pathways
 12.6 TLR5 TLR4 TLR2 RELA IFNG
15
TRAF Pathway 63
Show member pathways
 12.59 TLR9 TLR5 TLR4 TLR3 TLR2
16
NF-kappaB Signaling 4
12.57 TLR9 TLR3 TLR2 RELA IFNG
17
VEGF Pathway (Qiagen) 63
Show member pathways
 12.43 TLR9 TLR5 TLR4 TLR3 TLR2
18
Shigellosis 36
12.4 TLR5 TLR4 RELA CXCL8
19
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.34 CXCR3 CXCL8 CXCL11 CCL18
20
Toll Comparative Pathway 63
Show member pathways
 12.33 TLR4 TLR3 RELA IFNG CXCL8
21
Proteoglycans in cancer 36
12.3 TLR4 TLR2 MMP2 ITGA2
22
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.28 TLR9 TLR5 TLR4 TLR3 TLR2 RELA
23
Toxoplasmosis 36
Show member pathways
 12.26 TLR4 TLR2 RELA IFNG
24
Tuberculosis 36
12.25 TLR9 TLR4 TLR2 RELA IFNG
25
NOD-like receptor signaling pathway 36
12.23 TLR4 RELA DEFB4A CXCL8
26
IL-17 Family Signaling Pathways 64
Show member pathways
 12.09 TLR5 TLR2 RELA MMP3 MMP1 IFNG
27
MAPK Pathway 70
Show member pathways
 12.08 TLR9 TLR5 TLR4 TLR3 TLR2 RELA
28
Interleukin-4 and 13 signaling 65
12 MMP3 MMP2 MMP1 CXCL8
29
Amoebiasis 36
11.95 TLR4 TLR2 RELA IFNG CXCL8
30
Matrix Metalloproteinases 1
Show member pathways
 11.92 MMP7 MMP3 MMP2 MMP1
31
Rheumatoid arthritis 36
11.92 TLR4 TLR2 MMP3 MMP1 IFNG CXCL8
32
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 11.86 TLR4 RELA CXCL8
33
Corticotropin-releasing hormone signaling pathway 1
11.86 TLR4 RELA CXCL8
34
Angiogenesis (CST) 4
11.84 MMP7 MMP3 MMP2
35
Th17 Differentiation Pathway 64
Show member pathways
 11.84 TLR9 TLR5 TLR4 TLR3 TLR2 IFNG
36
Glucocorticoid receptor regulatory network 1
11.83 RELA MMP1 IFNG CXCL8
37
Colorectal Cancer Metastasis 63
11.83 TLR9 TLR5 TLR4 TLR3 TLR2 MMP7
38
Phagocytosis of Microbes 63
11.77 TLR9 TLR5 TLR4 TLR3 TLR2 ITGA2
39
Pertussis 36
11.76 TLR4 RELA CXCL8
40
Bladder cancer 36 1
11.74 MMP2 MMP1 CXCL8
41
Cell adhesion_ECM remodeling 23
11.72 MMP7 MMP3 MMP2 MMP1 CXCL8
42
IgA-Producing B Cells in the Intestine 64
11.71 TLR9 TLR5 TLR4 TLR2
43
AGE/RAGE pathway 1
11.69 RELA MMP7 MMP2
44
LPA receptor mediated events 1
11.68 RELA MMP2 CXCL8
45
Legionellosis 36
11.68 TLR5 TLR4 TLR2 RELA CXCL8
46
Th1 Differentiation Pathway 64
Show member pathways
 11.68 TLR9 TLR5 TLR4 TLR3 TLR2 IFNG
47
Lung fibrosis 1
11.66 MMP2 CXCL8 CALCA
48
ATF-2 transcription factor network 1
11.6 MMP2 IFNG CXCL8
49
Malaria 36
11.59 TLR9 TLR4 TLR2 IFNG CXCL8
50
MSP-RON Signaling 63
11.53 TLR4 TLR2 IFNG
Sources

GO Terms for Septic Arthritis

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Cellular components related to Septic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.73 TLR4 TLR3 TLR2 MMP7 ITGA2 CXCR3
2 extracellular space GO:0005615 9.7 TLR3 MMP7 MMP3 MMP2 IFNG DEFB4A
3 extracellular matrix GO:0031012 9.55 TLR3 MMP7 MMP3 MMP2 MMP1
4 extracellular region GO:0005576 9.44 TREM1 TLR9 MMP7 MMP3 MMP2 MMP1

Biological processes related to Septic Arthritis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.35 TLR9 TLR5 TLR4 TLR3 TLR2 CXCR3
2 innate immune response GO:0045087 10.15 TREM1 TLR9 TLR5 TLR4 TLR3 TLR2
3 positive regulation of gene expression GO:0010628 10.14 TLR9 TLR4 TLR3 TLR2 IFNG CXCL8
4 cytokine-mediated signaling pathway GO:0019221 10.08 RELA MMP3 MMP2 MMP1 CXCL8
5 defense response to bacterium GO:0042742 10.07 TLR9 TLR5 TLR4 TLR3 DEFB4A
6 extracellular matrix organization GO:0030198 10.07 MMP7 MMP3 MMP2 MMP1 ITGA2
7 cellular response to lipopolysaccharide GO:0071222 10.03 TLR5 TLR4 RELA CXCL8 CXCL11
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.03 TLR9 TLR4 TLR3 TLR2 RELA
9 chemotaxis GO:0006935 10.02 DEFB4A CXCR3 CXCL8 CXCL11 CCL18
10 defense response GO:0006952 10.02 TLR3 RELA DEFB4A CXCL8 CXCL11
11 defense response to virus GO:0051607 10.01 TLR9 TLR3 RELA IFNG
12 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10 TLR9 TLR4 TLR3 RELA
13 cellular response to tumor necrosis factor GO:0071356 9.99 RELA CXCL8 CCL18 CALCA
14 cellular response to interferon-gamma GO:0071346 9.95 TLR4 TLR3 TLR2 CCL18
15 chemokine-mediated signaling pathway GO:0070098 9.95 CXCR3 CXCL8 CXCL11 CCL18
16 extracellular matrix disassembly GO:0022617 9.94 MMP7 MMP3 MMP2 MMP1
17 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.94 TLR9 TLR4 TLR3 RELA
18 positive regulation of interleukin-6 production GO:0032755 9.93 TLR9 TLR4 TLR3 TLR2 IFNG
19 positive regulation of tumor necrosis factor production GO:0032760 9.92 TLR9 TLR4 TLR3 TLR2 IFNG
20 cellular response to mechanical stimulus GO:0071260 9.91 TLR5 TLR4 TLR3 MMP7 ITGA2
21 defense response to Gram-negative bacterium GO:0050829 9.9 TLR9 TLR4 DEFB4A
22 positive regulation of JNK cascade GO:0046330 9.9 TLR9 TLR4 TLR3
23 cellular response to interleukin-1 GO:0071347 9.89 RELA CXCL8 CCL18
24 neutrophil chemotaxis GO:0030593 9.89 CXCL8 CXCL11 CCL18
25 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.89 DEFB4A CXCL8 CXCL11
26 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.89 TLR9 TLR4 TLR3 TLR2 RELA
27 positive regulation of interferon-gamma production GO:0032729 9.88 TLR9 TLR4 TLR3
28 positive regulation of protein complex assembly GO:0031334 9.88 MMP3 MMP1 IFNG
29 collagen catabolic process GO:0030574 9.88 MMP7 MMP3 MMP2 MMP1
30 positive regulation of cytokine production GO:0001819 9.87 TLR5 TLR3 IFNG
31 positive regulation of nitric oxide biosynthetic process GO:0045429 9.87 TLR5 TLR4 IFNG
32 positive regulation of interferon-beta production GO:0032728 9.87 TLR9 TLR4 TLR3 TLR2
33 positive regulation of interleukin-10 production GO:0032733 9.86 TLR9 TLR4 TLR2
34 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.86 TLR9 TLR5 TLR4 TLR2
35 microglial cell activation GO:0001774 9.85 TLR3 TLR2 IFNG
36 toll-like receptor signaling pathway GO:0002224 9.85 TLR9 TLR5 TLR4 TLR3 TLR2
37 positive regulation of inflammatory response GO:0050729 9.85 TLR9 TLR4 TLR3 TLR2 ITGA2 IFNG
38 negative regulation of osteoclast differentiation GO:0045671 9.83 TLR4 TLR3 CALCA
39 positive regulation of interferon-alpha production GO:0032727 9.83 TLR9 TLR4 TLR3
40 positive regulation of chemokine production GO:0032722 9.8 TLR9 TLR4 TLR3 TLR2 IFNG
41 cellular response to UV-A GO:0071492 9.79 MMP3 MMP2 MMP1
42 response to molecule of bacterial origin GO:0002237 9.78 TLR9 TLR2 CXCL8
43 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.78 TLR9 TLR4 TLR2 IFNG
44 cellular response to lipoteichoic acid GO:0071223 9.77 TLR4 TLR2 RELA
45 regulation of cytokine secretion GO:0050707 9.75 TLR9 TLR5 TLR2
46 I-kappaB phosphorylation GO:0007252 9.73 TLR9 TLR4 TLR3 TLR2
47 positive regulation of interleukin-12 production GO:0032735 9.73 TLR9 TLR4 TLR3 TLR2 RELA IFNG
48 T cell chemotaxis GO:0010818 9.72 CXCR3 CXCL11
49 positive regulation of MHC class II biosynthetic process GO:0045348 9.72 TLR4 IFNG
50 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.71 TLR4 TLR3

Molecular functions related to Septic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.76 IFNG CXCL8 CXCL11 CCL18
2 serine-type endopeptidase activity GO:0004252 9.73 MMP7 MMP3 MMP2 MMP1
3 metallopeptidase activity GO:0008237 9.67 MMP7 MMP3 MMP2 MMP1
4 amyloid-beta binding GO:0001540 9.65 TLR4 TLR2 ITGA2
5 chemokine activity GO:0008009 9.58 CXCL8 CXCL11 CCL18
6 metalloendopeptidase activity GO:0004222 9.56 MMP7 MMP3 MMP2 MMP1
7 transmembrane signaling receptor activity GO:0004888 9.55 TLR9 TLR5 TLR4 TLR3 TLR2
8 lipopolysaccharide receptor activity GO:0001875 9.32 TLR4 TLR2
9 endopeptidase activity GO:0004175 9.26 MMP7 MMP3 MMP2 MMP1
10 signaling receptor activity GO:0038023 9.1 TREM1 TLR5 TLR4 TLR3 TLR2 CXCR3
Sources

Sources for Septic Arthritis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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