MCID: SPT004
MIFTS: 60

Septic Arthritis

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Septic Arthritis

Summaries for Septic Arthritis

MedlinePlus : 43 Most kinds of arthritis cause pain and swelling in your joints. Joints are places where two bones meet, such as your elbow or knee. Infectious arthritis is an infection in the joint. The infection comes from a bacterial, viral, or fungal infection that spreads from another part of the body. Symptoms of infectious arthritis include Intense pain in the joint Joint redness and swelling Chills and fever Inability to move the area with the infected joint One type of infectious arthritis is reactive arthritis. The reaction is to an infection somewhere else in your body. The joint is usually the knee, ankle, or toe. Sometimes, reactive arthritis is set off by an infection in the bladder, or in the urethra, which carries urine out of the body. In women, an infection in the vagina can cause the reaction. For both men and women, it can start with bacteria passed on during sex. Another form of reactive arthritis starts with eating food or handling something that has bacteria on it. To diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. Treatment includes medicines and sometimes surgery.

MalaCards based summary : Septic Arthritis, also known as infectious arthritis, is related to mycobacterium kansasii and haemophilus influenzae, and has symptoms including back pain, fever and muscle cramp. An important gene associated with Septic Arthritis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Hyaluronic acid and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, testes and bone, and related phenotypes are hematopoietic system and cardiovascular system

Disease Ontology : 12 An arthritis that involves infection by a pathogen located in joint.

NIH Rare Diseases : 53 Infectious arthritis is joint pain, soreness, stiffness and swelling caused by a bacterial, viral, or fungal infection that spreads from another part of the body. Depending on the type of infection, one or more joints may be affected. Certain bacteria can cause a form of infectious arthritis called reactive arthritis, which appears to be caused by the immune system reacting to bacteria, rather than by the infection itself. In reactive arthritis, joint inflammation develops weeks, months or even years after the infection. Reactive arthritis happens most commonly after infections of the genital and gastrointestinal tracts. To diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. Treatment includes medicines and sometimes surgery.

Wikipedia : 76 Septic arthritis, also known as joint infection or infectious arthritis, is the invasion of a joint by... more...

Related Diseases for Septic Arthritis

Diseases related to Septic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 260)
# Related Disease Score Top Affiliating Genes
1 mycobacterium kansasii 31.0 CXCL8 TLR2
2 haemophilus influenzae 30.9 CXCL8 TLR2
3 prosthetic joint infection 30.7 TLR2 TLR4
4 endocarditis 30.5 CRP CXCL8 TLR2
5 synovitis 30.3 CRP CXCL8 MMP3
6 discitis 30.2 CALCA CRP
7 otitis media 30.2 CXCL8 TLR2 TLR4
8 mycobacterium abscessus 30.2 CXCL8 TLR2
9 lemierre's syndrome 30.2 CRP TLR5
10 pyelonephritis 29.9 CRP CXCL8 TLR4
11 chorioamnionitis 29.9 CRP CXCL8 TLR4
12 peritonitis 29.9 CRP CXCL8 TLR2
13 sapho syndrome 29.7 CALCA CXCL8
14 pneumonia 29.3 CRP CXCL8 TLR2 TLR4 TLR5
15 aspergillosis 29.2 IFNG TLR2 TLR4
16 salmonellosis 29.0 DEFB4A IFNG TLR4
17 melioidosis 28.9 IFNG TLR2 TLR4 TLR5
18 wegener granulomatosis 28.8 CRP CXCL8 IFNG
19 brucellosis 28.8 CRP CXCL8 IFNG TLR4
20 rheumatoid arthritis 28.3 CRP CXCL8 IFNG MMP3 TLR2 TLR4
21 ophthalmia neonatorum 11.1
22 arthritis 11.0
23 trench fever 10.8 TLR2 TLR4
24 acute cervicitis 10.8 TLR2 TLR4
25 penicilliosis 10.8 TLR2 TLR4
26 dental abscess 10.8 CRP TLR4
27 mycobacterium chelonae 10.7 CXCL8 TLR2
28 alveolar echinococcosis 10.7 TLR2 TLR4
29 pyelitis 10.7 CRP TLR4
30 spastic entropion 10.7 MMP2 MMP3
31 mesenteric lymphadenitis 10.7 CRP TLR2
32 neurosyphilis 10.6 CXCL8 TLR2
33 pouchitis 10.6 CXCL8 TLR4
34 conjunctivochalasis 10.6 MMP2 MMP3
35 adenomyosis 10.6 MMP2 MMP3
36 slow-channel congenital myasthenic syndrome 10.6 CRP CXCL8
37 pyuria 10.6 CRP CXCL8
38 corneal ulcer 10.6 MMP2 MMP3
39 cardiac rupture 10.6 CRP CXCL8
40 scrub typhus 10.6 CRP TLR2 TLR4
41 pelvic inflammatory disease 10.5 CRP TLR2 TLR4
42 neisseria meningitidis infection 10.5 TLR2 TLR4
43 lipid pneumonia 10.5 CRP CXCR3
44 endometrial disease 10.5 CXCL8 TLR4
45 louse-borne relapsing fever 10.5 CRP CXCL8
46 acute transverse myelitis 10.5 CXCL8 MMP2
47 sorsby fundus dystrophy 10.5 MMP2 MMP3
48 sepsis in premature infants 10.5 CALCA CRP
49 osteomyelitis 10.4
50 cellulitis 10.4 CRP DEFB4A

Comorbidity relations with Septic Arthritis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Septic Arthritis:



Diseases related to Septic Arthritis

Symptoms & Phenotypes for Septic Arthritis

UMLS symptoms related to Septic Arthritis:


back pain, fever, muscle cramp, pruritus, sciatica

MGI Mouse Phenotypes related to Septic Arthritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.92 MMP3 TLR2 CXCR3 TLR4 IFNG TLR5
2 cardiovascular system MP:0005385 9.91 MMP2 CRP TLR2 CXCR3 TLR4 TLR5
3 homeostasis/metabolism MP:0005376 9.91 MMP3 TLR2 CRP CXCR3 TLR4 IFNG
4 immune system MP:0005387 9.76 MMP2 MMP3 TLR2 CRP CXCR3 TLR4
5 neoplasm MP:0002006 9.35 MMP2 TLR2 CXCR3 TLR4 IFNG
6 respiratory system MP:0005388 9.1 TLR2 CXCR3 TLR4 IFNG TLR5 MMP2

Drugs & Therapeutics for Septic Arthritis

Drugs for Septic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4,Not Applicable 9004-61-9 53477741
2
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
3
Teicoplanin Approved, Investigational Phase 4 61036-62-2
4
Cefazolin Approved Phase 4,Phase 3 25953-19-9 656510 33255
5
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
6
Vancomycin Approved Phase 4,Phase 3 1404-90-6 441141 14969
7
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
8
Dalbavancin Approved, Investigational Phase 4 91097-81-3, 171500-79-1 122186
9
Nafcillin Approved, Investigational Phase 4 985-16-0, 147-52-4 8982
10
Linezolid Approved, Investigational Phase 4,Phase 3 165800-03-3 441401
11 Adjuvants, Immunologic Phase 4,Not Applicable
12 Viscosupplements Phase 4,Not Applicable
13 Antibodies Phase 4,Phase 3,Phase 2,Early Phase 1
14 Immunoglobulins Phase 4,Phase 3,Phase 2,Early Phase 1
15 Immunoglobulins, Intravenous Phase 4,Phase 3,Phase 2
16 Protective Agents Phase 4,Not Applicable
17 Chlorhexidine gluconate Phase 4
18 Rho(D) Immune Globulin Phase 4,Phase 3,Phase 2
19 gamma-Globulins Phase 4,Phase 3,Phase 2
20 Dermatologic Agents Phase 4,Phase 3
21 Disinfectants Phase 4
22 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Early Phase 1
23 Anti-Infective Agents, Local Phase 4
24 Clindamycin palmitate Phase 4
25 Clindamycin phosphate Phase 4
26 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Early Phase 1
27 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Early Phase 1
28 Antitubercular Agents Phase 4
29
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
30
Amoxicillin Approved, Vet_approved Phase 2, Phase 3 26787-78-0 33613
31
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
32
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
33 Folic Acid Antagonists Phase 3
34 Nucleic Acid Synthesis Inhibitors Phase 3
35 Vitamin B Complex Phase 3
36 Pharmaceutical Solutions Phase 3
37 Immunoglobulin G Phase 3,Phase 2
38 Immunosuppressive Agents Phase 3
39 Antirheumatic Agents Phase 3
40 Antimetabolites Phase 3
41 Antimetabolites, Antineoplastic Phase 3
42 proline Nutraceutical Phase 3
43 Folate Nutraceutical Phase 3
44 Vitamin B9 Nutraceutical Phase 3
45
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616
46
Calcitonin gene-related peptide Investigational 83652-28-2
47 calcitonin
48 Vaccines
49 Vasodilator Agents
50 Hylan Not Applicable

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
2 Safety and Efficacy Study of Flebogamma 5% DIF IGIV in Pediatric Subjects Completed NCT00634569 Phase 4
3 Post-Operative Colonization Rates of Femoral Nerve Catheters Treated With Chlorhexidine-Impregnated Patch Completed NCT01411891 Phase 4
4 Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
5 Antibiotics Usage in Pediatric Orthopaedic Percutaneous Surgery (APOPS) Recruiting NCT03261830 Phase 4 Cefazolin;Clindamycin;Saline
6 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
7 Efficacy and Safety Study of Kedrion IVIG 10% to Treat Subjects With Primary Immunodeficiency (PID) Unknown status NCT01581593 Phase 3
8 Open Label, Phase III Study of NABI-IGIV 10% [Immune Globulin Intravenous(Human), 10%] In Subjects With Primary Immune Deficiency Disorders (PIDD) Completed NCT00538915 Phase 3
9 A Study of NewGam, Human Immunoglobulin 10%, in Patients With Primary Immunodeficiency Diseases Completed NCT01012323 Phase 3
10 Immune Globulin Subcutaenous (Human), 20% Completed NCT01412385 Phase 2, Phase 3
11 Extension Study of Subcutaneous Immunoglobulin Human in Patients With Primary Immunodeficiency (PID) Completed NCT00719680 Phase 3
12 Study of Subcutaneous Immunoglobulin in Patients With PID Requiring IgG Replacement Therapy Completed NCT00419341 Phase 3
13 Gammagard Liquid and rHuPH20 in PID Completed NCT00814320 Phase 3
14 Multicenter Study of Long-Term Clinical Outcomes of Subcutaneous Immune Globulin IgPro20 in Subjects With Primary Immunodeficiency (Japan Study) Completed NCT01461018 Phase 3
15 Safety and Efficacy of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID) Completed NCT00322556 Phase 3 Immunoglobulins Intravenous (Human)
16 Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy Completed NCT00542997 Phase 3
17 Follow-up Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (Japan Study) Completed NCT01458171 Phase 3
18 Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (EU Extension Study) Completed NCT00751621 Phase 3
19 A Study to Evaluate Efficacy of Tocilizumab Administered as Monotherapy or in Combination With Methotrexate and/or Other Disease Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis (RA) Participants Completed NCT01941940 Phase 3 Tocilizumab;DMARDs
20 Twice Daily Treatment With Amoxicillin for Non-severe Community Acquired Pneumonia. Recruiting NCT03031210 Phase 2, Phase 3 Amoxicillin
21 Study of Octanorm Subcutaneous IG in Patients With PID Recruiting NCT01888484 Phase 3
22 Study of Immune Globulin Intravenous (Human) GC5101F in Subjects With Primary Humoral Immunodeficiency Not yet recruiting NCT03492710 Phase 3
23 Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections Terminated NCT00108433 Phase 3 Cefazolin IV;Linezolid IV;Vancomycin (IV)
24 Surgical Lavage vs Serial Needle Aspiration for Infected Joints Withdrawn NCT00313365 Phase 3
25 Arthrocentesis Study Unknown status NCT02530229
26 ARTEMIS Synovial Markers in Arthritis Childhood Unknown status NCT02505828 Not Applicable
27 Ultrasonography Assessment of Septic Arthritis on Native Joint Completed NCT02018952 Not Applicable
28 Pro-calcitonin for Early Detection of Septic Arthritis Completed NCT02085733
29 Use of Infrared Spectroscopy in Septic Arthritis Diagnosis Completed NCT02860871
30 Determination of New Biomarkers of Septic Arthritis by Surface-Enhanced Laser Desorption/Ionization Time-Of-Flight (SELDI-TOF) Completed NCT01010165
31 Molecular Microbiology in Osteo-arthritis Infection Completed NCT01193803
32 The Application of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Sepsis & Relevant Acute Kidney Injuries Completed NCT01333657
33 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Completed NCT00933296
34 Irrigation Versus no Irrigation for Cutaneous Abscess Completed NCT01606657 Not Applicable
35 Procalcitonin Level and Kinetics in Children With Bacterial Infections Completed NCT00714402
36 Efficacy of OSTENIL PLUS (Hyaluronic Acid) Versus SYNVISC-ONE in Patients With Tibiofemoral Osteoarthritis Completed NCT03203408 Not Applicable
37 Analysis of Human Knee Joint Fluid Using Metabonomic, Genomic and Tribology Techniques Recruiting NCT02565160
38 Operative and Non-operative Treatment of Traumatic Arthrotomies Recruiting NCT02841644
39 Safety Study of Univers® Revers Shoulder Prosthesis Active, not recruiting NCT01778777 Not Applicable
40 Ankle Joint Replacement Outcomes Study Active, not recruiting NCT00503438 Not Applicable
41 Personalized Immunotherapeutic for Antibiotic-resistant Infection Enrolling by invitation NCT02508584 Early Phase 1
42 Utilization of Leukocyte Esterase in the Diagnosis of Pediatric Joint Infections Terminated NCT02032732

Search NIH Clinical Center for Septic Arthritis

Cochrane evidence based reviews: arthritis, infectious

Genetic Tests for Septic Arthritis

Anatomical Context for Septic Arthritis

The Foundational Model of Anatomy Ontology organs/tissues related to Septic Arthritis:

19
Joint

MalaCards organs/tissues related to Septic Arthritis:

41
Testes, Bone, Myeloid, Colon, Kidney, Skin, Neutrophil

Publications for Septic Arthritis

Articles related to Septic Arthritis:

(show top 50) (show all 786)
# Title Authors Year
1
Bacteremia and Septic Arthritis due to a Nontoxigenic Strain of<i>Clostridium difficile</i>in a Patient With Sickle Cell Disease. ( 29410974 )
2018
2
Acute septic arthritis of the knee: A rare case report of infection with Parvimonas micra after an intra-articular corticosteroid injection for osteoarthritis. ( 29305995 )
2018
3
Increased Mortality and Reoperation Rates After Treatment for Septic Arthritis of the Knee in People Who Inject Drugs: Nationwide Inpatient Sample, 2000-2013. ( 29762153 )
2018
4
Incidental diagnosis of sternoclavicular septic arthritis with <i>Moraxella nonliquefaciens</i>. ( 29942746 )
2018
5
Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of <i>Staphylococcus aureus</i>-Induced Septic Arthritis. ( 29867945 )
2018
6
Arthroscopic debridement for septic arthritis of the shoulder joint: post-infectious arthritis is an inevitable consequence? ( 29777344 )
2018
7
Validating an Algorithm to Predict Adjacent Musculoskeletal Infections in Pediatric Patients With Septic Arthritis. ( 29389760 )
2018
8
Host Factors Affect the Outcome of Arthroscopic Lavage Treatment of Septic Arthritis of the Knee. ( 29309715 )
2018
9
Long-term results of bacterial septic arthritis of the wrist. ( 29891427 )
2018
10
Factors Related to Surgical Treatment and Outcomes of Thai Patients With Septic Arthritis. ( 29912769 )
2018
11
Pyomyositis presenting as septic arthritis. ( 29559212 )
2018
12
Suture-induced arthritis as a clinical mimicker of septic arthritis. ( 29445456 )
2018
13
Septic arthritis caused by Granulicatella adiacens after anterior cruciate ligament reconstruction. ( 29422445 )
2018
14
Disseminated Exophiala dermatitidis causing septic arthritis and osteomyelitis. ( 29866071 )
2018
15
Bilateral septic arthritis of the sternoclavicular joint complicating infective endocarditis: a case report. ( 29973288 )
2018
16
Septic Arthritis of the Wrist. ( 29329124 )
2018
17
Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton. ( 29396671 )
2018
18
Atypical Mycobacterial Septic Arthritis of the Wrist: A Report of Two Cases. ( 29952776 )
2018
19
Current clinical and bacteriological profile of septic arthritis in young infants: a prospective study from a tertiary referral centre. ( 29427091 )
2018
20
Septic arthritis due to oral streptococci following intra-articular injection: A case series. ( 29805059 )
2018
21
Radiographic Study of Haematogenous Septic Arthritis in Dairy Calves. ( 29908523 )
2018
22
Isolated septic arthritis of hip joint: a rare presentation of melioidosis. A case report. ( 29351806 )
2018
23
Group B streptococcus septic arthritis of the hip following spontaneous abortion. ( 29326375 )
2018
24
Septic Arthritis, Osteomyelitis, and Pyomyositis in a Previously Healthy Infant. ( 29293205 )
2018
25
Neutralization of TNFR-1 and TNFR-2 modulates S. aureus induced septic arthritis by regulating the levels of pro inflammatory and anti inflammatory cytokines during the progression of the disease. ( 29339199 )
2018
26
Acute septic arthritis of shoulder joint caused by Aeromonas veronii biotype sobria. ( 29872872 )
2018
27
Septic arthritis of the sternoclavicular joint: A unique late complication after tracheostomy. ( 29776683 )
2018
28
Neutrophils: Beneficial and Harmful Cells in Septic Arthritis. ( 29401737 )
2018
29
Don't put your foot in it: a case of talonavicular septic arthritis. ( 29374644 )
2018
30
Ultrasound-guided synovial biopsy improves diagnosis of septic arthritis in acute arthritis without enough analyzable synovial fluid: a retrospective analysis of 176 arthritis from a French rheumatology department. ( 29948353 )
2018
31
Patient Factors Associated With Methicillin-Resistant Staphylococcus aureus Septic Arthritis in Children. ( 29451940 )
2018
32
Acromioclavicular joint septic arthritis in an immunocompetent child: AA caseA report. ( 29773450 )
2018
33
Editor's Spotlight/Take 5: Increased Mortality and Reoperation Rates After Treatment for Septic Arthritis of the Knee in People Who Inject Drugs: Nationwide Inpatient Sample, 2000-2013. ( 29912747 )
2018
34
Septic arthritis of the temporomandibular joint leading to an epidural abscess. ( 29895543 )
2018
35
Septic Arthritis/Osteomyelitis May Lead to Osteochondrosis-Like Lesions in Foals. ( 29807507 )
2018
36
Comparison of several biomarkers (MMP-2, MMP-9, the MMP-9 inhibitor TIMP-1, CTX-II, calprotectin, and COMP) in the synovial fluid and serum of patients with and without septic arthritis. ( 29787810 )
2018
37
Lumbar spine epidural abscess and facet joint septic arthritis due to Streptococcus agalactiae: a case report. ( 29534714 )
2018
38
MRI findings for unilateral sternoclavicular arthritis: differentiation between infectious arthritis and spondyloarthritis. ( 29978244 )
2018
39
Imaging of Posttraumatic Arthritis, Avascular Necrosis, Septic Arthritis, Complex Regional Pain Syndrome, and Cancer Mimicking Arthritis. ( 28774452 )
2017
40
Effect of arthroscopic lavage and repeated intra-articular administrations of antibiotic in adult horses and foals with septic arthritis. ( 28771839 )
2017
41
Septic arthritis significantly increased the long-term mortality in geriatric patients. ( 28793879 )
2017
42
<i>S. lugdunensis</i> Native-Joint Septic Arthritis: Case Report and Review of the Literature. ( 29445553 )
2017
43
Lemierre's syndrome; a rare cause of septic arthritis. ( 28500126 )
2017
44
Clinical significance of delta neutrophil index in the differential diagnosis between septic arthritis and acute gout attack within 24 hours after hospitalization. ( 28746185 )
2017
45
Haemophilus influenzae serotype f endocarditis and septic arthritis. ( 28725560 )
2017
46
Spontaneous Bilateral Sternoclavicular Joint Septic Arthritis and Lumbar Discitis: An Unusual Case in a Healthy Adult. ( 29130010 )
2017
47
Concomitant crystal-induced and septic arthritis. ( 28725566 )
2017
48
Primary Septic Arthritis of The Knee due to Mycobacterium Tuberculosis in a Previously Healthy Child. ( 29301169 )
2017
49
Acute osteomyelitis and septic arthritis in children : AA referral hospital-based study in Iran. ( 28744778 )
2017
50
Cutibacteriumacnes Septic Arthritis of the Nonoperated Knee: A Case Report. ( 28825032 )
2017

Variations for Septic Arthritis

Expression for Septic Arthritis

Search GEO for disease gene expression data for Septic Arthritis.

Pathways for Septic Arthritis

Pathways related to Septic Arthritis according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 CRP CXCL8 DEFB4A IFNG MMP2 MMP3
2
Show member pathways
13.23 CXCL8 CXCR3 ITGA2 TLR2 TLR4 TLR5
3
Show member pathways
12.85 CXCL8 IFNG TLR2 TLR4 TLR5
4 12.68 CXCL8 IFNG ITGA2 MMP2
5
Show member pathways
12.65 IFNG TLR2 TLR4 TLR5
6
Show member pathways
12.63 CXCL8 IFNG TLR2 TLR4
7
Show member pathways
12.36 TLR2 TLR4 TLR5
8
Show member pathways
12.31 IFNG TLR2 TLR4 TLR5
9 12.15 ITGA2 MMP2 TLR2 TLR4
10
Show member pathways
12.12 CXCL8 IFNG TLR4
11
Show member pathways
12.12 CXCL8 TLR2 TLR4 TLR5
12
Show member pathways
12.11 IFNG TLR2 TLR4
13 12.09 IFNG TLR2 TLR4
14
Show member pathways
12.09 IFNG TLR2 TLR4 TLR5
15
Show member pathways
12.08 CXCL8 TLR2 TLR5
16 11.99 ITGA2 TLR2 TLR4
17 11.94 IFNG MMP2 TLR2 TLR4 TLR5
18
Show member pathways
11.89 TLR2 TLR4 TLR5
19 11.87 CXCL8 IFNG TLR4
20 11.84 CXCL8 MMP2 MMP3
21
Show member pathways
11.77 CXCL8 DEFB4A IFNG MMP3 TLR2 TLR5
22 11.76 CXCL8 IFNG TLR2 TLR4
23 11.69 CXCL8 IFNG TLR4 TLR5
24 11.66 ITGA2 TLR2 TLR4 TLR5
25 11.55 CALCA CXCL8 MMP2
26 11.53 CXCL8 MMP2 MMP3
27 11.51 CXCL8 IFNG MMP3 TLR2 TLR4
28
Show member pathways
11.5 CXCL8 IFNG MMP2 MMP3
29 11.47 CXCL8 IFNG MMP2
30 11.41 CXCL8 TLR2 TLR4 TLR5
31 11.38 IFNG TLR2 TLR4
32
Show member pathways
11.32 CXCL8 DEFB4A IFNG TLR2 TLR4 TLR5
33 11.25 CXCL8 IFNG TLR2 TLR4
34 11.19 CXCL8 ITGA2 MMP2
35 11.04 IFNG TLR2
36 10.91 CRP CXCL8

GO Terms for Septic Arthritis

Cellular components related to Septic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CALCA CRP CXCL8 DEFB4A IFNG MMP2
2 extracellular space GO:0005615 9.17 CALCA CRP CXCL8 DEFB4A IFNG MMP2
3 intrinsic component of plasma membrane GO:0031226 9.16 TLR2 TLR4

Biological processes related to Septic Arthritis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.93 CRP TLR2 TLR4 TLR5
2 positive regulation of gene expression GO:0010628 9.87 CRP IFNG TLR2 TLR4
3 immune response GO:0006955 9.83 CXCL8 DEFB4A IFNG TLR2 TLR4
4 response to lipopolysaccharide GO:0032496 9.8 CXCL8 TLR2 TLR4
5 response to hypoxia GO:0001666 9.79 ITGA2 MMP2 TLR2
6 chemotaxis GO:0006935 9.78 CXCL8 CXCR3 DEFB4A
7 cellular response to lipopolysaccharide GO:0071222 9.75 CXCL8 TLR4 TLR5
8 defense response to Gram-positive bacterium GO:0050830 9.7 CRP DEFB4A TLR2
9 cellular response to mechanical stimulus GO:0071260 9.65 ITGA2 TLR4 TLR5
10 positive regulation of inflammatory response GO:0050729 9.63 ITGA2 TLR2 TLR4
11 positive regulation of interferon-beta production GO:0032728 9.62 TLR2 TLR4
12 negative regulation of osteoclast differentiation GO:0045671 9.6 CALCA TLR4
13 positive regulation of interleukin-10 production GO:0032733 9.59 TLR2 TLR4
14 positive regulation of chemokine production GO:0032722 9.58 TLR2 TLR4
15 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.56 TLR2 TLR4
16 response to molecule of bacterial origin GO:0002237 9.55 CXCL8 TLR2
17 I-kappaB phosphorylation GO:0007252 9.54 TLR2 TLR4
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.54 IFNG TLR4 TLR5
19 cellular response to lipoteichoic acid GO:0071223 9.51 TLR2 TLR4
20 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.5 TLR2 TLR4 TLR5
21 negative regulation of interleukin-17 production GO:0032700 9.49 IFNG TLR4
22 positive regulation of interleukin-12 production GO:0032735 9.43 IFNG TLR2 TLR4
23 positive regulation of toll-like receptor signaling pathway GO:0034123 9.4 TLR2 TLR5
24 regulation of cytokine secretion GO:0050707 9.33 TLR2 TLR4 TLR5
25 positive regulation of interleukin-8 production GO:0032757 9.26 CALCA TLR2 TLR4 TLR5
26 inflammatory response GO:0006954 9.17 CALCA CRP CXCL8 CXCR3 TLR2 TLR4

Molecular functions related to Septic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 9.13 CALCA ITGA2 TLR2
2 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Septic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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