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MCID: SPT004
MIFTS: 61

Septic Arthritis

Categories: Blood diseases, Bone diseases, Infectious diseases, Nephrological diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Septic Arthritis

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MalaCards integrated aliases for Septic Arthritis:

Name: Septic Arthritis 12 54 15
Infectious Arthritis 12 77 54 44 17
Arthritis, Infectious 45 74
Arthritis, Bacterial 74
Arthritis Septic 56

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Bone diseases Nephrological diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34


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Summaries for Septic Arthritis

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MedlinePlus : 44 Most kinds of arthritis cause pain and swelling in your joints. Joints are places where two bones meet, such as your elbow or knee. Infectious arthritis is an infection in the joint. The infection comes from a bacterial, viral, or fungal infection that spreads from another part of the body. Symptoms of infectious arthritis include Intense pain in the joint Joint redness and swelling Chills and fever Inability to move the area with the infected joint One type of infectious arthritis is reactive arthritis. The reaction is to an infection somewhere else in your body. The joint is usually the knee, ankle, or toe. Sometimes, reactive arthritis is set off by an infection in the bladder, or in the urethra, which carries urine out of the body. In women, an infection in the vagina can cause the reaction. For both men and women, it can start with bacteria passed on during sex. Another form of reactive arthritis starts with eating food or handling something that has bacteria on it. To diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. Treatment includes medicines and sometimes surgery.

MalaCards based summary : Septic Arthritis, also known as infectious arthritis, is related to haemophilus influenzae and endocarditis, and has symptoms including fever, pruritus and back pain. An important gene associated with Septic Arthritis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Hyaluronic acid and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, testes and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

Disease Ontology : 12 An arthritis that involves infection by a pathogen located in joint.

NIH Rare Diseases : 54 Infectious arthritis is joint pain, soreness, stiffness and swelling caused by a bacterial, viral, or fungal infection that spreads from another part of the body. Depending on the type of infection, one or more joints may be affected. Certain bacteria can cause a form of infectious arthritis called reactive arthritis, which appears to be caused by the immune system reacting to bacteria, rather than by the infection itself. In reactive arthritis, joint inflammation develops weeks, months or even years after the infection. Reactive arthritis happens most commonly after infections of the genital and gastrointestinal tracts. To diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. Treatment includes medicines and sometimes surgery.

Wikipedia : 77 Septic arthritis, also known as joint infection or infectious arthritis, is the invasion of a joint by... more...

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Related Diseases for Septic Arthritis

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Diseases related to Septic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 317)
# Related Disease Score Top Affiliating Genes
1 haemophilus influenzae 31.1 CXCL8 TLR2
2 endocarditis 30.8 CRP CXCL8 TLR2
3 synovitis 30.7 CRP CXCL8 MMP3
4 mycobacterium kansasii 30.7 CXCL8 TLR2
5 mycobacterium marinum 30.6 CXCL8 TLR2
6 otitis media 30.4 CXCL8 TLR2 TLR4
7 melioidosis 30.3 IFNG TLR2 TLR4
8 mycobacterium abscessus 30.2 CXCL8 TLR2
9 prosthetic joint infection 30.2 TLR2 TLR4
10 pneumonia 30.2 CRP CXCL8 TLR2 TLR4
11 systemic lupus erythematosus 30.0 CRP CXCR3 IFNG TLR2 TLR4
12 pyelonephritis 30.0 CRP CXCL8 TLR4
13 rheumatoid arthritis 30.0 CRP CXCL8 IFNG MMP3 TLR2 TLR4
14 crohn's colitis 29.9 CXCL8 IFNG
15 spondyloarthropathy 1 29.9 CRP MMP3 TLR4
16 meningitis 29.9 CRP CXCL8 IFNG TLR2
17 bacterial meningitis 29.8 CRP CXCL8 TLR2
18 peritonitis 29.8 CRP CXCL8 TLR2
19 chorioamnionitis 29.8 CRP CXCL8 TLR4
20 bone inflammation disease 29.8 CRP CXCL8 IFNG MMP3
21 aspergillosis 29.7 IFNG TLR2 TLR4
22 typhoid fever 29.7 CRP IFNG TLR4
23 dermatitis, atopic 29.6 CXCL8 DEFB4A IFNG
24 brucellosis 29.5 CRP CXCL8 IFNG TLR4
25 allergic contact dermatitis 29.5 CXCL8 CXCR3 IFNG
26 contact dermatitis 29.5 CXCL8 CXCR3 IFNG
27 tonsillitis 29.4 CXCL8 DEFB4A IFNG
28 toxic shock syndrome 29.3 CXCL8 IFNG TLR2 TLR4
29 bacterial infectious disease 28.7 CRP CXCL8 DEFB4A IFNG TLR2 TLR4
30 arthritis 11.4
31 ophthalmia neonatorum 11.3
32 shigellosis 11.0
33 osteomyelitis 10.9
34 trench fever 10.4 TLR2 TLR4
35 fungal keratitis 10.4 TLR2 TLR4
36 acute cervicitis 10.4 TLR2 TLR4
37 penicilliosis 10.4 TLR2 TLR4
38 dental abscess 10.4 CRP TLR4
39 gout 10.3
40 spondylarthropathy 10.3 TLR2 TLR4
41 pyomyositis 10.3
42 lupus erythematosus 10.3
43 mesenteric lymphadenitis 10.3 CRP TLR2
44 chondrocalcinosis 10.3
45 mycobacterium chelonae 10.3 CXCL8 TLR2
46 lipid pneumonia 10.3 CRP CXCR3
47 neisseria meningitidis infection 10.3 TLR2 TLR4
48 spastic entropion 10.3 MMP2 MMP3
49 neurosyphilis 10.3 CXCL8 TLR2
50 pouchitis 10.3 CXCL8 TLR4

Comorbidity relations with Septic Arthritis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Septic Arthritis:



Diseases related to Septic Arthritis
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Symptoms & Phenotypes for Septic Arthritis

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UMLS symptoms related to Septic Arthritis:


fever, pruritus, back pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Septic Arthritis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 CRP CXCR3 IFNG MMP10 MMP11 MMP2
2 homeostasis/metabolism MP:0005376 9.97 CRP CXCR3 IFNG ITGA2 MMP11 MMP2
3 immune system MP:0005387 9.86 CRP CXCR3 IFNG MMP10 MMP2 MMP3
4 neoplasm MP:0002006 9.63 CXCR3 IFNG MMP11 MMP2 TLR2 TLR4
5 normal MP:0002873 9.5 CXCR3 IFNG ITGA2 MMP10 MMP2 TLR2
6 respiratory system MP:0005388 9.1 CXCR3 IFNG MMP10 MMP2 TLR2 TLR4
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Drugs & Therapeutics for Septic Arthritis

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Drugs for Septic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4,Not Applicable 9004-61-9 53477741
2
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
3
Vancomycin Approved Phase 4,Phase 3,Not Applicable 1404-90-6 14969 441141
4
Dalbavancin Approved, Investigational Phase 4 171500-79-1, 91097-81-3 122186
5
Nafcillin Approved, Investigational Phase 4 985-16-0, 147-52-4 8982
6
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
7
Teicoplanin Approved, Investigational Phase 4 61036-62-2
8
Cefazolin Approved Phase 4,Phase 3 25953-19-9 33255 656510
9
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
10
Ceftaroline fosamil Approved, Investigational Phase 4 229016-73-3
11
Linezolid Approved, Investigational Phase 4,Phase 3 165800-03-3 441401
12 Protective Agents Phase 4,Not Applicable
13 Adjuvants, Immunologic Phase 4,Not Applicable
14 Viscosupplements Phase 4,Not Applicable
15 Immunologic Factors Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
16 Immunoglobulins, Intravenous Phase 4,Phase 3,Phase 2,Not Applicable
17 Immunoglobulins Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
18 Antibodies Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
19 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
20 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
21 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable
22 gamma-Globulins Phase 4,Phase 3,Phase 2,Not Applicable
23 Rho(D) Immune Globulin Phase 4,Phase 3,Phase 2,Not Applicable
24 Disinfectants Phase 4
25 Chlorhexidine gluconate Phase 4
26 Dermatologic Agents Phase 4,Phase 3
27 Anti-Infective Agents, Local Phase 4
28 Antitubercular Agents Phase 4,Not Applicable
29 Clindamycin palmitate Phase 4
30 Clindamycin phosphate Phase 4
31
leucovorin Approved Phase 3 58-05-9 143 6006
32
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
33
Amoxicillin Approved, Vet_approved Phase 2, Phase 3,Not Applicable 26787-78-0 33613
34
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
35
tannic acid Approved Phase 3 1401-55-4
36
Proline Approved, Nutraceutical Phase 3 147-85-3 145742
37
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
38 Immunoglobulin G Phase 3,Phase 2
39 Pharmaceutical Solutions Phase 3
40 Antimetabolites, Antineoplastic Phase 3
41 Nucleic Acid Synthesis Inhibitors Phase 3
42 Antirheumatic Agents Phase 3
43 Vitamin B9 Phase 3
44 Folate Phase 3
45 Immunosuppressive Agents Phase 3
46 Vitamin B Complex Phase 3
47 Folic Acid Antagonists Phase 3
48 Antimetabolites Phase 3
49
Cephalexin Approved, Investigational, Vet_approved Phase 1 15686-71-2 27447
50
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616

Interventional clinical trials:

(show top 50) (show all 53)
# Name Status NCT ID Phase Drugs
1 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
2 Safety and Efficacy Study of Flebogamma 5% DIF IGIV in Pediatric Subjects Completed NCT00634569 Phase 4
3 Post-Operative Colonization Rates of Femoral Nerve Catheters Treated With Chlorhexidine-Impregnated Patch Completed NCT01411891 Phase 4
4 Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
5 Antibiotics Usage in Pediatric Orthopaedic Percutaneous Surgery (APOPS) Recruiting NCT03261830 Phase 4 Cefazolin;Clindamycin;Saline
6 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
7 Efficacy and Safety Study of Kedrion IVIG 10% to Treat Subjects With Primary Immunodeficiency (PID) Unknown status NCT01581593 Phase 3
8 Open Label, Phase III Study of NABI-IGIV 10% [Immune Globulin Intravenous(Human), 10%] In Subjects With Primary Immune Deficiency Disorders (PIDD) Completed NCT00538915 Phase 3
9 A Study of NewGam, Human Immunoglobulin 10%, in Patients With Primary Immunodeficiency Diseases Completed NCT01012323 Phase 3
10 Immune Globulin Subcutaenous (Human), 20% Completed NCT01412385 Phase 2, Phase 3
11 Extension Study of Subcutaneous Immunoglobulin Human in Patients With Primary Immunodeficiency (PID) Completed NCT00719680 Phase 3
12 Study of Subcutaneous Immunoglobulin in Patients With PID Requiring IgG Replacement Therapy Completed NCT00419341 Phase 3
13 Gammagard Liquid and rHuPH20 in PID Completed NCT00814320 Phase 3
14 Multicenter Study of Long-Term Clinical Outcomes of Subcutaneous Immune Globulin IgPro20 in Subjects With Primary Immunodeficiency (Japan Study) Completed NCT01461018 Phase 3
15 Safety and Efficacy of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID) Completed NCT00322556 Phase 3 Immunoglobulins Intravenous (Human)
16 Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy Completed NCT00542997 Phase 3
17 Follow-up Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (Japan Study) Completed NCT01458171 Phase 3
18 Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (EU Extension Study) Completed NCT00751621 Phase 3
19 A Study to Evaluate Efficacy of Tocilizumab Administered as Monotherapy or in Combination With Methotrexate and/or Other Disease Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis (RA) Participants Completed NCT01941940 Phase 3 Tocilizumab;DMARDs
20 Efficacy, Safety and Pharmacokinetics Study of Kedrion IVIG 10% to Treat Participants With Primary Immunodeficiency (PID) Recruiting NCT03961009 Phase 3
21 Twice Daily Treatment With Amoxicillin for Non-severe Community Acquired Pneumonia. Recruiting NCT03031210 Phase 2, Phase 3 Amoxicillin
22 Study of Octanorm Subcutaneous IG in Patients With PID Active, not recruiting NCT01888484 Phase 3
23 Study of Immune Globulin Intravenous (Human) GC5101F in Subjects With Primary Humoral Immunodeficiency Not yet recruiting NCT03492710 Phase 3
24 Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections Terminated NCT00108433 Phase 3 Cefazolin IV;Linezolid IV;Vancomycin (IV)
25 Surgical Lavage vs Serial Needle Aspiration for Infected Joints Withdrawn NCT00313365 Phase 3
26 Cefadroxil and Cephalexin Drug Levels and Dosing in Pediatric Musculoskeletal Infections Not yet recruiting NCT03802552 Phase 1 Cefadroxil;Cephalexin
27 Arthrocentesis Study Unknown status NCT02530229
28 Analysis of Human Knee Joint Fluid Using Metabonomic, Genomic and Tribology Techniques Unknown status NCT02565160
29 Personalized Immunotherapeutic for Antibiotic-resistant Infection Unknown status NCT02508584 Early Phase 1
30 Ultrasonography Assessment of Septic Arthritis on Native Joint Completed NCT02018952 Not Applicable
31 Pro-calcitonin for Early Detection of Septic Arthritis Completed NCT02085733
32 Use of Infrared Spectroscopy in Septic Arthritis Diagnosis Completed NCT02860871
33 Determination of New Biomarkers of Septic Arthritis by Surface-Enhanced Laser Desorption/Ionization Time-Of-Flight (SELDI-TOF) Completed NCT01010165
34 ARTEMIS Synovial Markers in Arthritis Childhood Completed NCT02505828 Not Applicable
35 Molecular Microbiology in Osteo-arthritis Infection Completed NCT01193803
36 Two Versus Four Weeks of Antibiotic Treatment in Native Joint Arthritis Completed NCT03615781 Not Applicable Two week's arm - drugs;Four week's arm - drugs
37 The Application of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Sepsis & Relevant Acute Kidney Injuries Completed NCT01333657
38 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Completed NCT00933296
39 Irrigation Versus no Irrigation for Cutaneous Abscess Completed NCT01606657 Not Applicable
40 Procalcitonin Level and Kinetics in Children With Bacterial Infections Completed NCT00714402
41 Efficacy of OSTENIL PLUS (Hyaluronic Acid) Versus SYNVISC-ONE in Patients With Tibiofemoral Osteoarthritis Completed NCT03203408 Not Applicable
42 Short 3-week Antibiotic Treatment Versus 6 Weeks in Adults With Septic Arthritis of Native Joint Recruiting NCT03716921 Not Applicable
43 Alpha-Defensin and Synovial Proteins to Improve Detection of Pediatric Septic Arthritis Recruiting NCT03704766 Not Applicable
44 External Validation of a Septic Arthritis Prognosis Score Recruiting NCT03819855
45 Differentiate Children Septic and Inflammatory Arthritis by Comparative Analysis Recruiting NCT03827759
46 Long- and Midterm Outcomes of Osteoarticular Infections in Paediatric Patients Recruiting NCT03827980
47 Operative and Non-operative Treatment of Traumatic Arthrotomies Recruiting NCT02841644
48 Osteoarticular Infections With Pneumococcal Recruiting NCT03852784
49 Safety Study of Univers® Revers Shoulder Prosthesis Active, not recruiting NCT01778777 Not Applicable
50 Ankle Joint Replacement Outcomes Study Active, not recruiting NCT00503438 Not Applicable

Search NIH Clinical Center for Septic Arthritis

Cochrane evidence based reviews: arthritis, infectious

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Genetic Tests for Septic Arthritis

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Anatomical Context for Septic Arthritis

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The Foundational Model of Anatomy Ontology organs/tissues related to Septic Arthritis:

20
Joint

MalaCards organs/tissues related to Septic Arthritis:

42
Testes, Kidney, Colon, Myeloid, Skin, Bone, Cervix
Sources

Publications for Septic Arthritis

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Articles related to Septic Arthritis:

(show top 50) (show all 2438)
# Title Authors Year
1
CORR Insights®: Patients with a History of Treated Septic Arthritis are at High Risk of Periprosthetic Joint Infection after Total Joint Arthroplasty. ( 31107320 )
2019
2
Nationwide epidemiologic study for pediatric osteomyelitis and septic arthritis in South Korea: A cross-sectional study of national health insurance review and assessment service. ( 31027117 )
2019
3
Value of serum procalcitonin for the diagnosis of bacterial septic arthritis in daily practice in rheumatology. ( 30989408 )
2019
4
Pediatric Septic Arthritis of the Knee: Predictors of Septic Hip Do Not Apply. ( 30950940 )
2019
5
Outcomes of paediatric septic arthritis of the hip and knee at 1-20 years in an Australian urban centre. ( 30959561 )
2019
6
Predicting Periarticular Infection in Children With Septic Arthritis of the Hip: Regionally Derived Criteria May Not Apply to All Populations. ( 30969258 )
2019
7
Septic arthritis following femoral neck fracture: A case report. ( 30974413 )
2019
8
Post-arthroscopic septic arthritis of the knee. Analysis of the outcome after treatment in a case series and systematic literature review. ( 30977874 )
2019
9
Acute osteomyelitis and septic arthritis in children: a systematic review of systematic reviews. ( 30977881 )
2019
10
Clinical characteristics of patients with polymicrobial septic arthritis. ( 30980263 )
2019
11
Calprotectin discriminates septic arthritis from pseudogout and rheumatoid arthritis. ( 30919904 )
2019
12
Septic arthritis due to streptococci and enterococci in native joints: a 13 year retrospective study. ( 30929143 )
2019
13
Epidemiology, management and outcomes of large and small native joint septic arthritis in adults. ( 30941403 )
2019
14
Native Joint Septic Arthritis: Comparison of Outcomes with Medical and Surgical Management. ( 30943544 )
2019
15
Septic Arthritis of the Native Ankle. ( 30889008 )
2019
16
Candida glabrata-Induced Refractory Infectious Arthritis: A Case Report and Literature Review. ( 30903581 )
2019
17
Calcium pyrophosphate dihydrate crystal deposition disease and MRSA septic arthritis of the atlantoaxial joint in a patient with Tourette syndrome. ( 30904893 )
2019
18
Patients with a History of Treated Septic Arthritis are at High Risk of Periprosthetic Joint Infection after Total Joint Arthroplasty. ( 30913112 )
2019
19
Evaluation and Management of Septic Arthritis and its Mimics in the Emergency Department. ( 30881554 )
2019
20
The predictive value of synovial glucose level in septic arthritis. ( 30882559 )
2019
21
Broad-range 16 s rDNA PCR in synovial fluid does not improve the diagnostic performance of septic arthritis in native joints in adults: cross-sectional single-center study in 95 patients. ( 30850963 )
2019
22
A nationwide analysis of failed irrigation and debridement for pediatric septic arthritis of the hip. ( 30855548 )
2019
23
Performance of automated multiplex polymerase chain reaction (mPCR) using synovial fluid in the diagnosis of native joint septic arthritis in adults. ( 30813795 )
2019
24
Factors associated with septic arthritis of the distal interphalangeal joint in beef cattle: A case-control study. ( 30825885 )
2019
25
Surgical management of sternoclavicular joint septic arthritis. ( 30828216 )
2019
26
Native Joint Septic Arthritis due to Clostridium tarantellae. ( 30753899 )
2019
27
Effects of Antibiotics on α-Toxin Levels during Staphylococcus aureus Culture: Implications for the Protection of Chondrocytes in a Model of Septic Arthritis. ( 30762428 )
2019
28
The Incidence of Pin Tract Infections and Septic Arthritis in Percutaneous Distal Femur Pinning. ( 30762618 )
2019
29
Septic Arthritis Following Radiofrequency Ablation of the Genicular Nerves. ( 30698785 )
2019
30
The role of real-time PCR testing in the investigation of paediatric patients with community-onset osteomyelitis and septic arthritis. ( 30706296 )
2019
31
Can C-Reactive Protein Be Used to Predict Acute Septic Arthritis in the Adult Population? ( 30708377 )
2019
32
Moraxella nonliquefaciens septic arthritis in a hematopoietic stem cell transplant patient a case report and review of the literature. ( 30711347 )
2019
33
Use of standard diagnostic techniques to determine eradication of infection in experimental equine septic arthritis. ( 30670899 )
2019
34
Septic arthritis caused by Salmonella enterica serotype Rubislaw: A case report. ( 30652794 )
2019
35
Septic arthritis of the hip and knee treated surgically in pediatric patients: Analysis of the Kids' Inpatient Database. ( 30655655 )
2019
36
Vancomycin-soaking of the graft reduces the incidence of septic arthritis following ACL reconstruction: results of a systematic review and meta-analysis. ( 30656372 )
2019
37
Septic Arthritis of the Hip-Risk Factors Associated With Secondary Surgery. ( 30520802 )
2019
38
Early Detection of Inflammation and Joint Destruction Revealed by Ultrasound in a Patient with Sternoclavicular Septic Arthritis. ( 30449803 )
2019
39
Septic arthritis of the pediatric hip: update on diagnosis and treatment. ( 30461509 )
2019
40
Early diagnosis of septic arthritis using synovial fluid presepsin: A preliminary study. ( 30473180 )
2019
41
Professional Athletes Are Not at a Higher Risk of Infections After Anterior Cruciate Ligament Reconstruction: Incidence of Septic Arthritis, Additional Costs, and Clinical Outcomes From the French Prospective Anterior Cruciate Ligament Study (FAST) Cohort. ( 30481480 )
2019
42
A case of acute septic arthritis of the hip joint caused by Panton-Valentine leukocidin-positive ST772 community-acquired methicillin-resistant Staphylococcus aureus. ( 30217733 )
2019
43
Medical Versus Surgical Approach to Initial Treatment in Septic Arthritis: A Single Spanish Center's 8-Year Experience. ( 29215382 )
2019
44
Comparison of several biomarkers (MMP-2, MMP-9, the MMP-9 inhibitor TIMP-1, CTX-II, calprotectin, and COMP) in the synovial fluid and serum of patients with and without septic arthritis. ( 29787810 )
2019
45
Kingella kingae Septic Arthritis in an Older-Than-Expected Child. ( 30016451 )
2019
46
MRI findings for unilateral sternoclavicular arthritis: differentiation between infectious arthritis and spondyloarthritis. ( 29978244 )
2019
47
Osteosarcoma of the Proximal Femur Mimicking Septic Arthritis of the Hip: A diagnostic dilemma. ( 30988979 )
2018
48
Septic arthritis. ( 30805552 )
2018
49
Psoas Abscess with Septic Arthritis of the Hip in a Patient with Chronic Back Pain. ( 30740521 )
2018
50
Utility of point-of-care synovial lactate to identify septic arthritis in the emergency department. ( 30593442 )
2018
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Variations for Septic Arthritis

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Expression for Septic Arthritis

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Search GEO for disease gene expression data for Septic Arthritis.
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Pathways for Septic Arthritis

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Pathways related to Septic Arthritis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.84 CRP CXCL8 DEFB4A IFNG MMP2 MMP3
2
Integrin Pathway 65
Show member pathways
 13.21 CXCL8 CXCR3 ITGA2 MMP10 MMP11 MMP2
3
Pathways in cancer 38
12.66 CXCL8 IFNG ITGA2 MMP2
4
Degradation of the extracellular matrix 67
Show member pathways
 12.59 ITGA2 MMP10 MMP11 MMP2 MMP3
5
IL-17 Family Signaling Pathways 66
Show member pathways
 12.19 CXCL8 DEFB4A IFNG MMP3 TLR2
6
Proteoglycans in cancer 38
12.16 ITGA2 MMP2 TLR2 TLR4
7
Diseases associated with the TLR signaling cascade 67
Show member pathways
 12.11 CXCL8 TLR2 TLR4
8
Toxoplasmosis 38
Show member pathways
 12.09 IFNG TLR2 TLR4
9
Tuberculosis 38
12.06 IFNG TLR2 TLR4
10
Phagosome 38
11.98 ITGA2 TLR2 TLR4
11
Bacterial infections in CF airways 23
Show member pathways
 11.98 CXCL8 DEFB4A IFNG TLR2 TLR4
12
Colorectal Cancer Metastasis 65
11.94 IFNG MMP11 MMP2 TLR2 TLR4
13
Th1 Differentiation Pathway 66
Show member pathways
 11.9 IFNG TLR2 TLR4
14
Spinal Cord Injury 1
11.86 CXCL8 IFNG TLR4
15
Interleukin-4 and 13 signaling 67
11.83 CXCL8 MMP2 MMP3
16
Matrix Metalloproteinases 1
Show member pathways
 11.79 MMP10 MMP11 MMP2 MMP3
17
Amoebiasis 38
11.76 CXCL8 IFNG TLR2 TLR4
18
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 11.71 CXCL8 CXCR3 ITGA2 MMP10 MMP11 MMP2
19
Salmonella infection (KEGG) 38
11.7 CXCL8 IFNG TLR4
20
Phagocytosis of Microbes 65
11.69 ITGA2 TLR2 TLR4
21
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.53 CXCL8 IFNG MMP2 MMP3
22
Rheumatoid arthritis 38
11.51 CXCL8 IFNG MMP3 TLR2 TLR4
23
ATF-2 transcription factor network 1
11.49 CXCL8 IFNG MMP2
24
Cell adhesion_ECM remodeling 23
11.49 CXCL8 MMP10 MMP2 MMP3
25
Legionellosis 38
11.48 CXCL8 TLR2 TLR4
26
MSP-RON Signaling 65
11.4 IFNG TLR2 TLR4
27
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 11.27 IFNG MMP10 MMP11 MMP2 MMP3 TLR2
28
Malaria 38
11.25 CXCL8 IFNG TLR2 TLR4
29
Syndecan-2-mediated signaling events 1
11.2 CXCL8 ITGA2 MMP2
30
A-beta Pathways: Uptake and Degradation 66
11.16 MMP2 TLR4
31
IL1 and megakaryocytes in obesity 1
11.03 IFNG TLR2
32
Overview of nanoparticle effects 1
10.9 CRP CXCL8
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GO Terms for Septic Arthritis

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Cellular components related to Septic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CRP CXCL8 DEFB4A IFNG MMP10 MMP2
2 extracellular matrix GO:0031012 9.46 MMP10 MMP11 MMP2 MMP3
3 extracellular region GO:0005576 9.23 CRP CXCL8 DEFB4A IFNG MMP10 MMP11

Biological processes related to Septic Arthritis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.86 CRP IFNG TLR2 TLR4
2 inflammatory response GO:0006954 9.8 CRP CXCL8 CXCR3 TLR2 TLR4
3 chemotaxis GO:0006935 9.75 CXCL8 CXCR3 DEFB4A
4 immune response GO:0006955 9.73 CXCL8 CXCR3 DEFB4A IFNG TLR2 TLR4
5 defense response to Gram-positive bacterium GO:0050830 9.65 CRP DEFB4A TLR2
6 positive regulation of inflammatory response GO:0050729 9.61 ITGA2 TLR2 TLR4
7 positive regulation of interleukin-8 production GO:0032757 9.6 TLR2 TLR4
8 positive regulation of interferon-beta production GO:0032728 9.59 TLR2 TLR4
9 positive regulation of interleukin-10 production GO:0032733 9.58 TLR2 TLR4
10 positive regulation of chemokine production GO:0032722 9.57 TLR2 TLR4
11 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.55 TLR2 TLR4
12 regulation of cytokine secretion GO:0050707 9.54 TLR2 TLR4
13 I-kappaB phosphorylation GO:0007252 9.52 TLR2 TLR4
14 negative regulation of interleukin-17 production GO:0032700 9.51 IFNG TLR4
15 positive regulation of interleukin-12 production GO:0032735 9.5 IFNG TLR2 TLR4
16 response to molecule of bacterial origin GO:0002237 9.49 CXCL8 TLR2
17 cellular response to lipoteichoic acid GO:0071223 9.46 TLR2 TLR4
18 extracellular matrix disassembly GO:0022617 9.46 MMP10 MMP11 MMP2 MMP3
19 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.37 TLR2 TLR4
20 response to hypoxia GO:0001666 9.13 ITGA2 MMP2 TLR2
21 collagen catabolic process GO:0030574 8.92 MMP10 MMP11 MMP2 MMP3

Molecular functions related to Septic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.62 MMP10 MMP11 MMP2 MMP3
2 serine-type endopeptidase activity GO:0004252 9.26 MMP2 MMP3
3 metallopeptidase activity GO:0008237 9.26 MMP10 MMP11 MMP2 MMP3
4 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
5 metalloendopeptidase activity GO:0004222 8.92 MMP10 MMP11 MMP2 MMP3
Sources

Sources for Septic Arthritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
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45 MeSH
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47 MGI
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55 NINDS
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63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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