MCID: SPT004
MIFTS: 61

Septic Arthritis

Categories: Blood diseases, Bone diseases, Infectious diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Septic Arthritis

MalaCards integrated aliases for Septic Arthritis:

Name: Septic Arthritis 12 53 15
Infectious Arthritis 12 76 53 43
Arthritis, Infectious 44 73
Arthritis, Bacterial 73
Arthritis Septic 55

Classifications:



Summaries for Septic Arthritis

MedlinePlus : 43 Most kinds of arthritis cause pain and swelling in your joints. Joints are places where two bones meet, such as your elbow or knee. Infectious arthritis is an infection in the joint. The infection comes from a bacterial, viral, or fungal infection that spreads from another part of the body. Symptoms of infectious arthritis include Intense pain in the joint Joint redness and swelling Chills and fever Inability to move the area with the infected joint One type of infectious arthritis is reactive arthritis. The reaction is to an infection somewhere else in your body. The joint is usually the knee, ankle, or toe. Sometimes, reactive arthritis is set off by an infection in the bladder, or in the urethra, which carries urine out of the body. In women, an infection in the vagina can cause the reaction. For both men and women, it can start with bacteria passed on during sex. Another form of reactive arthritis starts with eating food or handling something that has bacteria on it. To diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. Treatment includes medicines and sometimes surgery.

MalaCards based summary : Septic Arthritis, also known as infectious arthritis, is related to haemophilus influenzae and mycobacterium kansasii, and has symptoms including fever, pruritus and back pain. An important gene associated with Septic Arthritis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Hyaluronic acid and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, testes and bone, and related phenotypes are homeostasis/metabolism and immune system

Disease Ontology : 12 An arthritis that involves infection by a pathogen located in joint.

NIH Rare Diseases : 53 Infectious arthritis is joint pain, soreness, stiffness and swelling caused by a bacterial, viral, or fungal infection that spreads from another part of the body. Depending on the type of infection, one or more joints may be affected. Certain bacteria can cause a form of infectious arthritis called reactive arthritis, which appears to be caused by the immune system reacting to bacteria, rather than by the infection itself. In reactive arthritis, joint inflammation develops weeks, months or even years after the infection. Reactive arthritis happens most commonly after infections of the genital and gastrointestinal tracts. To diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. Treatment includes medicines and sometimes surgery.

Wikipedia : 76 Septic arthritis, also known as joint infection or infectious arthritis, is the invasion of a joint by... more...

Related Diseases for Septic Arthritis

Diseases related to Septic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 287)
# Related Disease Score Top Affiliating Genes
1 haemophilus influenzae 30.6 CXCL8 TLR2
2 mycobacterium kansasii 30.5 CXCL8 TLR2
3 endocarditis 30.5 CRP CXCL8 TLR2
4 mycobacterium marinum 30.4 CXCL8 TLR2
5 otitis media 30.3 CXCL8 TLR2 TLR4
6 synovitis 30.1 CRP CXCL8 MMP1 MMP3
7 rheumatoid arthritis 30.1 CRP CXCL8 MMP1 MMP3 TLR2 TLR4
8 mycobacterium abscessus 30.0 CXCL8 TLR2
9 prosthetic joint infection 29.9 TLR2 TLR4
10 chromoblastomycosis 29.8 CXCR3 MMP1
11 myeloma, multiple 29.7 CRP CXCL8 TLR9
12 toxic shock syndrome 29.7 CXCL8 TLR2 TLR4
13 pyelonephritis 29.7 CRP CXCL8 TLR4
14 brucellosis 29.7 CRP CXCL8 TLR4
15 chorioamnionitis 29.7 CRP CXCL8 TLR4
16 peritonitis 29.7 CRP CXCL8 TLR2
17 systemic lupus erythematosus 29.6 CRP CXCL8 CXCR3 TLR2 TLR4 TLR9
18 pneumonia 29.6 CRP CXCL8 TLR2 TLR4 TLR9
19 aspergillosis 29.5 TLR2 TLR4 TLR9
20 bone inflammation disease 29.4 CRP CXCL8 MMP1 MMP3 TLR9
21 tonsillitis 29.3 CXCL8 DEFB4A TLR9
22 meningitis 29.3 CRP CXCL8 TLR2 TLR9
23 bacterial meningitis 29.2 CRP CXCL8 TLR2 TLR9
24 dermatitis, atopic 28.9 CXCL8 CXCR3 DEFB4A TLR2 TLR4 TLR9
25 ophthalmia neonatorum 11.2
26 arthritis 11.2
27 shigellosis 11.0
28 osteomyelitis 10.6
29 pyomyositis 10.3
30 trench fever 10.3 TLR2 TLR4
31 fungal keratitis 10.2 TLR2 TLR4
32 acute cervicitis 10.2 TLR2 TLR4
33 anterior uveitis 10.2 TLR2 TLR4
34 gout 10.2
35 dental abscess 10.2 CRP TLR4
36 penicilliosis 10.2 TLR2 TLR4
37 mycobacterium chelonae 10.2 CXCL8 TLR2
38 spondylarthropathy 10.2 TLR2 TLR4
39 sodoku disease 10.2
40 rat bite fever 10.2
41 mesenteric lymphadenitis 10.2 CRP TLR2
42 neisseria meningitidis infection 10.2 TLR2 TLR4
43 neurosyphilis 10.2 CXCL8 TLR2
44 lipid pneumonia 10.2 CRP CXCR3
45 pouchitis 10.2 CXCL8 TLR4
46 myasthenic syndrome, congenital, 1a, slow-channel 10.2 CRP CXCL8
47 lupus erythematosus 10.2
48 pyuria 10.2 CRP CXCL8
49 periodontitis, chronic 10.2 MMP1 TLR2
50 scrub typhus 10.2 CRP TLR2 TLR4

Comorbidity relations with Septic Arthritis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Septic Arthritis:



Diseases related to Septic Arthritis

Symptoms & Phenotypes for Septic Arthritis

UMLS symptoms related to Septic Arthritis:


fever, pruritus, back pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Septic Arthritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.81 CRP CXCR3 ITGA2 MMP1 MMP2 MMP3
2 immune system MP:0005387 9.56 CRP CXCR3 MMP1 MMP2 MMP3 TLR2
3 neoplasm MP:0002006 9.02 CXCR3 MMP1 MMP2 TLR2 TLR4

Drugs & Therapeutics for Septic Arthritis

Drugs for Septic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4,Not Applicable 9004-61-9 53477741
2
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
3
Vancomycin Approved Phase 4,Phase 3,Not Applicable 1404-90-6 14969 441141
4
Nafcillin Approved, Investigational Phase 4 985-16-0, 147-52-4 8982
5
Teicoplanin Approved, Investigational Phase 4 61036-62-2
6
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
7
Dalbavancin Approved, Investigational Phase 4 91097-81-3, 171500-79-1 122186
8
Cefazolin Approved Phase 4,Phase 3 25953-19-9 656510 33255
9
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
10
Linezolid Approved, Investigational Phase 4,Phase 3 165800-03-3 441401
11 Adjuvants, Immunologic Phase 4,Not Applicable
12 Immunologic Factors Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
13 Viscosupplements Phase 4,Not Applicable
14 Protective Agents Phase 4,Not Applicable
15 Immunoglobulins, Intravenous Phase 4,Phase 3,Phase 2
16 Antibodies Phase 4,Phase 3,Phase 2,Early Phase 1
17 Immunoglobulins Phase 4,Phase 3,Phase 2,Early Phase 1
18 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable
19 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable
20 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable
21 gamma-Globulins Phase 4,Phase 3,Phase 2
22 Rho(D) Immune Globulin Phase 4,Phase 3,Phase 2
23 Chlorhexidine gluconate Phase 4
24 Disinfectants Phase 4
25 Dermatologic Agents Phase 4,Phase 3
26 Anti-Infective Agents, Local Phase 4
27 Antitubercular Agents Phase 4,Not Applicable
28 Clindamycin palmitate Phase 4
29 Clindamycin phosphate Phase 4
30
leucovorin Approved Phase 3 58-05-9 6006 143
31
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
32
Amoxicillin Approved, Vet_approved Phase 2, Phase 3,Not Applicable 26787-78-0 33613
33 tannic acid Approved Phase 3
34
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
35
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
36 Pharmaceutical Solutions Phase 3
37 Immunoglobulin G Phase 3,Phase 2
38 proline Phase 3
39 Antirheumatic Agents Phase 3
40 Folic Acid Antagonists Phase 3
41 Immunosuppressive Agents Phase 3
42 Vitamin B9 Phase 3
43 Vitamin B Complex Phase 3
44 Antimetabolites, Antineoplastic Phase 3
45 Folate Phase 3
46 Antimetabolites Phase 3
47 Nucleic Acid Synthesis Inhibitors Phase 3
48
Salmon Calcitonin Approved, Investigational ,Not Applicable 47931-85-1 16129616
49
Calcitonin gene-related peptide Investigational ,Not Applicable 83652-28-2
50 Bone Density Conservation Agents ,Not Applicable

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
2 Safety and Efficacy Study of Flebogamma 5% DIF IGIV in Pediatric Subjects Completed NCT00634569 Phase 4
3 Post-Operative Colonization Rates of Femoral Nerve Catheters Treated With Chlorhexidine-Impregnated Patch Completed NCT01411891 Phase 4
4 Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
5 Antibiotics Usage in Pediatric Orthopaedic Percutaneous Surgery (APOPS) Recruiting NCT03261830 Phase 4 Cefazolin;Clindamycin;Saline
6 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
7 Efficacy and Safety Study of Kedrion IVIG 10% to Treat Subjects With Primary Immunodeficiency (PID) Unknown status NCT01581593 Phase 3
8 Open Label, Phase III Study of NABI-IGIV 10% [Immune Globulin Intravenous(Human), 10%] In Subjects With Primary Immune Deficiency Disorders (PIDD) Completed NCT00538915 Phase 3
9 A Study of NewGam, Human Immunoglobulin 10%, in Patients With Primary Immunodeficiency Diseases Completed NCT01012323 Phase 3
10 Immune Globulin Subcutaenous (Human), 20% Completed NCT01412385 Phase 2, Phase 3
11 Extension Study of Subcutaneous Immunoglobulin Human in Patients With Primary Immunodeficiency (PID) Completed NCT00719680 Phase 3
12 Study of Subcutaneous Immunoglobulin in Patients With PID Requiring IgG Replacement Therapy Completed NCT00419341 Phase 3
13 Gammagard Liquid and rHuPH20 in PID Completed NCT00814320 Phase 3
14 Multicenter Study of Long-Term Clinical Outcomes of Subcutaneous Immune Globulin IgPro20 in Subjects With Primary Immunodeficiency (Japan Study) Completed NCT01461018 Phase 3
15 Safety and Efficacy of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID) Completed NCT00322556 Phase 3 Immunoglobulins Intravenous (Human)
16 Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy Completed NCT00542997 Phase 3
17 Follow-up Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (Japan Study) Completed NCT01458171 Phase 3
18 Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (EU Extension Study) Completed NCT00751621 Phase 3
19 A Study to Evaluate Efficacy of Tocilizumab Administered as Monotherapy or in Combination With Methotrexate and/or Other Disease Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis (RA) Participants Completed NCT01941940 Phase 3 Tocilizumab;DMARDs
20 Twice Daily Treatment With Amoxicillin for Non-severe Community Acquired Pneumonia. Recruiting NCT03031210 Phase 2, Phase 3 Amoxicillin
21 Study of Octanorm Subcutaneous IG in Patients With PID Recruiting NCT01888484 Phase 3
22 Study of Immune Globulin Intravenous (Human) GC5101F in Subjects With Primary Humoral Immunodeficiency Not yet recruiting NCT03492710 Phase 3
23 Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections Terminated NCT00108433 Phase 3 Cefazolin IV;Linezolid IV;Vancomycin (IV)
24 Surgical Lavage vs Serial Needle Aspiration for Infected Joints Withdrawn NCT00313365 Phase 3
25 Cefadroxil and Cephalexin Drug Levels and Dosing in Pediatric Musculoskeletal Infections Not yet recruiting NCT03802552 Phase 1 Cefadroxil;Cephalexin
26 Arthrocentesis Study Unknown status NCT02530229
27 ARTEMIS Synovial Markers in Arthritis Childhood Unknown status NCT02505828 Not Applicable
28 Analysis of Human Knee Joint Fluid Using Metabonomic, Genomic and Tribology Techniques Unknown status NCT02565160
29 Personalized Immunotherapeutic for Antibiotic-resistant Infection Unknown status NCT02508584 Early Phase 1
30 Ultrasonography Assessment of Septic Arthritis on Native Joint Completed NCT02018952 Not Applicable
31 Pro-calcitonin for Early Detection of Septic Arthritis Completed NCT02085733
32 Use of Infrared Spectroscopy in Septic Arthritis Diagnosis Completed NCT02860871
33 Determination of New Biomarkers of Septic Arthritis by Surface-Enhanced Laser Desorption/Ionization Time-Of-Flight (SELDI-TOF) Completed NCT01010165
34 Molecular Microbiology in Osteo-arthritis Infection Completed NCT01193803
35 Two Versus Four Weeks of Antibiotic Treatment in Native Joint Arthritis Completed NCT03615781 Not Applicable Two week's arm - drugs;Four week's arm - drugs
36 The Application of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Sepsis & Relevant Acute Kidney Injuries Completed NCT01333657
37 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Completed NCT00933296
38 Irrigation Versus no Irrigation for Cutaneous Abscess Completed NCT01606657 Not Applicable
39 Procalcitonin Level and Kinetics in Children With Bacterial Infections Completed NCT00714402
40 Efficacy of OSTENIL PLUS (Hyaluronic Acid) Versus SYNVISC-ONE in Patients With Tibiofemoral Osteoarthritis Completed NCT03203408 Not Applicable
41 Alpha-Defensin and Synovial Proteins to Improve Detection of Pediatric Septic Arthritis Recruiting NCT03704766 Not Applicable
42 Operative and Non-operative Treatment of Traumatic Arthrotomies Recruiting NCT02841644
43 Safety Study of Univers® Revers Shoulder Prosthesis Active, not recruiting NCT01778777 Not Applicable
44 Ankle Joint Replacement Outcomes Study Active, not recruiting NCT00503438 Not Applicable
45 Short 3-week Antibiotic Treatment Versus 6 Weeks in Adults With Septic Arthritis of Native Joint Not yet recruiting NCT03716921 Not Applicable
46 Utilization of Leukocyte Esterase in the Diagnosis of Pediatric Joint Infections Terminated NCT02032732

Search NIH Clinical Center for Septic Arthritis

Cochrane evidence based reviews: arthritis, infectious

Genetic Tests for Septic Arthritis

Anatomical Context for Septic Arthritis

The Foundational Model of Anatomy Ontology organs/tissues related to Septic Arthritis:

19
Joint

MalaCards organs/tissues related to Septic Arthritis:

41
Testes, Bone, Skin, Liver, Tonsil, Cervix, Myeloid

Publications for Septic Arthritis

Articles related to Septic Arthritis:

(show top 50) (show all 1298)
# Title Authors Year
1
Bacteremia and Septic Arthritis due to a Nontoxigenic Strain of<i>Clostridium difficile</i>in a Patient With Sickle Cell Disease. ( 29410974 )
2018
2
Acute septic arthritis of the knee: A rare case report of infection with Parvimonas micra after an intra-articular corticosteroid injection for osteoarthritis. ( 29305995 )
2018
3
Increased Mortality and Reoperation Rates After Treatment for Septic Arthritis of the Knee in People Who Inject Drugs: Nationwide Inpatient Sample, 2000-2013. ( 29762153 )
2018
4
Incidental diagnosis of sternoclavicular septic arthritis with <i>Moraxella nonliquefaciens</i>. ( 29942746 )
2018
5
Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of <i>Staphylococcus aureus</i>-Induced Septic Arthritis. ( 29867945 )
2018
6
Arthroscopic debridement for septic arthritis of the shoulder joint: post-infectious arthritis is an inevitable consequence? ( 29777344 )
2018
7
Validating an Algorithm to Predict Adjacent Musculoskeletal Infections in Pediatric Patients With Septic Arthritis. ( 29389760 )
2018
8
Host Factors Affect the Outcome of Arthroscopic Lavage Treatment of Septic Arthritis of the Knee. ( 29309715 )
2018
9
Long-term results of bacterial septic arthritis of the wrist. ( 29891427 )
2018
10
Factors Related to Surgical Treatment and Outcomes of Thai Patients With Septic Arthritis. ( 29912769 )
2018
11
Pyomyositis presenting as septic arthritis. ( 29559212 )
2018
12
Suture-induced arthritis as a clinical mimicker of septic arthritis. ( 29445456 )
2018
13
Septic arthritis caused by Granulicatella adiacens after anterior cruciate ligament reconstruction. ( 29422445 )
2018
14
Disseminated Exophiala dermatitidis causing septic arthritis and osteomyelitis. ( 29866071 )
2018
15
Bilateral septic arthritis of the sternoclavicular joint complicating infective endocarditis: a case report. ( 29973288 )
2018
16
Septic Arthritis of the Wrist. ( 29329124 )
2018
17
Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton. ( 29396671 )
2018
18
Atypical Mycobacterial Septic Arthritis of the Wrist: A Report of Two Cases. ( 29952776 )
2018
19
Current clinical and bacteriological profile of septic arthritis in young infants: a prospective study from a tertiary referral centre. ( 29427091 )
2018
20
Septic arthritis due to oral streptococci following intra-articular injection: A case series. ( 29805059 )
2018
21
Radiographic Study of Haematogenous Septic Arthritis in Dairy Calves. ( 29908523 )
2018
22
Isolated septic arthritis of hip joint: a rare presentation of melioidosis. A case report. ( 29351806 )
2018
23
Group B streptococcus septic arthritis of the hip following spontaneous abortion. ( 29326375 )
2018
24
Septic Arthritis, Osteomyelitis, and Pyomyositis in a Previously Healthy Infant. ( 29293205 )
2018
25
Neutralization of TNFR-1 and TNFR-2 modulates S. aureus induced septic arthritis by regulating the levels of pro inflammatory and anti inflammatory cytokines during the progression of the disease. ( 29339199 )
2018
26
Acute septic arthritis of shoulder joint caused by Aeromonas veronii biotype sobria. ( 29872872 )
2018
27
Septic arthritis of the sternoclavicular joint: A unique late complication after tracheostomy. ( 29776683 )
2018
28
Neutrophils: Beneficial and Harmful Cells in Septic Arthritis. ( 29401737 )
2018
29
Don't put your foot in it: a case of talonavicular septic arthritis. ( 29374644 )
2018
30
Ultrasound-guided synovial biopsy improves diagnosis of septic arthritis in acute arthritis without enough analyzable synovial fluid: a retrospective analysis of 176 arthritis from a French rheumatology department. ( 29948353 )
2018
31
Patient Factors Associated With Methicillin-Resistant Staphylococcus aureus Septic Arthritis in Children. ( 29451940 )
2018
32
Acromioclavicular joint septic arthritis in an immunocompetent child: AA caseA report. ( 29773450 )
2018
33
Editor's Spotlight/Take 5: Increased Mortality and Reoperation Rates After Treatment for Septic Arthritis of the Knee in People Who Inject Drugs: Nationwide Inpatient Sample, 2000-2013. ( 29912747 )
2018
34
Septic arthritis of the temporomandibular joint leading to an epidural abscess. ( 29895543 )
2018
35
Septic Arthritis/Osteomyelitis May Lead to Osteochondrosis-Like Lesions in Foals. ( 29807507 )
2018
36
Comparison of several biomarkers (MMP-2, MMP-9, the MMP-9 inhibitor TIMP-1, CTX-II, calprotectin, and COMP) in the synovial fluid and serum of patients with and without septic arthritis. ( 29787810 )
2018
37
Lumbar spine epidural abscess and facet joint septic arthritis due to Streptococcus agalactiae: a case report. ( 29534714 )
2018
38
A Case of Upper Limb Osteomyelitis and Septic Arthritis Presenting as Pseudoparalysis in a Two-Week-Old. ( 30538880 )
2018
39
Septic Arthritis of the Hip-Risk Factors Associated With Secondary Surgery. ( 30520802 )
2018
40
Early Detection of Inflammation and Joint Destruction Revealed by Ultrasound in a Patient with Sternoclavicular Septic Arthritis. ( 30449803 )
2018
41
Septic arthritis caused by Staphylococcus caprae following arthroscopic meniscus tear repair in a patient without any foreign device. ( 30455044 )
2018
42
Septic arthritis of the pediatric hip: update on diagnosis and treatment. ( 30461509 )
2018
43
Early diagnosis of septic arthritis using synovial fluid presepsin: A preliminary study. ( 30473180 )
2018
44
Corticosteroids for septic arthritis in children. ( 30480764 )
2018
45
Professional Athletes Are Not at a Higher Risk of Infections After Anterior Cruciate Ligament Reconstruction: Incidence of Septic Arthritis, Additional Costs, and Clinical Outcomes From the French Prospective Anterior Cruciate Ligament Study (FAST) Cohort. ( 30481480 )
2018
46
An Unusual Presentation of Pectoralis Major Pyomyositis Presenting as Septic Arthritis of the Shoulder: A Case Report and Review of the Literature. ( 30423796 )
2018
47
Coexisting polyarticular septic arthritis, gout and pseudogout. ( 30373898 )
2018
48
Septic arthritis of the shoulder and elbow: one decade of epidemiological analysis at a tertiary referral hospital. ( 30377604 )
2018
49
Klebsiella pneumoniae sacroiliac septic arthritis: First case report. ( 30386726 )
2018
50
A comparison of Streptococcus agalactiae septic arthritis and non-Streptococcus agalactiae septic arthritis. ( 30386859 )
2018

Variations for Septic Arthritis

Expression for Septic Arthritis

Search GEO for disease gene expression data for Septic Arthritis.

Pathways for Septic Arthritis

Pathways related to Septic Arthritis according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 CRP CXCL8 DEFB4A MMP1 MMP2 MMP3
2
Show member pathways
13.24 CXCL11 CXCL8 CXCR3 ITGA2 TLR2 TLR4
3
Show member pathways
13.22 CXCL11 CXCL8 CXCR3 ITGA2 MMP1 MMP2
4
Show member pathways
12.85 CXCL11 CXCL8 TLR2 TLR4 TLR9
5 12.68 CXCL8 ITGA2 MMP1 MMP2
6
Show member pathways
12.64 CXCL8 TLR2 TLR4 TLR9
7
Show member pathways
12.59 ITGA2 MMP1 MMP2 MMP3
8 12.17 ITGA2 MMP2 TLR2 TLR4
9
Show member pathways
12.16 CXCL8 DEFB4A MMP1 MMP3 TLR2
10
Show member pathways
12.14 CXCL8 TLR2 TLR4 TLR9
11 12.08 TLR2 TLR4 TLR9
12 12 ITGA2 TLR2 TLR4
13 11.94 MMP1 MMP2 TLR2 TLR4 TLR9
14
Show member pathways
11.92 TLR2 TLR4 TLR9
15
Show member pathways
11.9 MMP2 MMP3 TLR2 TLR4
16
Show member pathways
11.89 TLR2 TLR4 TLR9
17
Show member pathways
11.86 CXCL11 CXCL8 CXCR3
18 11.84 CXCL8 MMP1 MMP2 MMP3
19
Show member pathways
11.78 MMP1 MMP2 MMP3
20 11.76 CXCL8 TLR2 TLR4
21 11.69 ITGA2 TLR2 TLR4 TLR9
22
Show member pathways
11.65 CXCL11 CXCL8 DEFB4A TLR2 TLR4 TLR9
23 11.62 CXCL8 MMP1 MMP2
24 11.51 CXCL8 MMP1 MMP3 TLR2 TLR4
25
Show member pathways
11.5 CXCL8 MMP1 MMP2 MMP3
26 11.49 CXCL8 TLR2 TLR4
27 11.45 CXCL8 MMP1 MMP2 MMP3
28
Show member pathways
11.43 CXCL11 CXCL8 CXCR3 ITGA2 MMP1 MMP2
29 11.25 CXCL8 TLR2 TLR4 TLR9
30 11.23 CXCL8 MMP1 MMP2
31 11.2 CXCL8 ITGA2 MMP2
32 10.97 MMP1 MMP2
33 10.91 CRP CXCL8

GO Terms for Septic Arthritis

Cellular components related to Septic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CRP CXCL11 CXCL8 DEFB4A MMP2 MMP3
2 extracellular region GO:0005576 9.23 CRP CXCL11 CXCL8 DEFB4A MMP1 MMP2

Biological processes related to Septic Arthritis according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.99 CRP TLR2 TLR4 TLR9
2 positive regulation of gene expression GO:0010628 9.97 CRP TLR2 TLR4 TLR9
3 cytokine-mediated signaling pathway GO:0019221 9.94 CXCL8 MMP1 MMP2 MMP3
4 response to hypoxia GO:0001666 9.88 ITGA2 MMP2 MMP3 TLR2
5 chemotaxis GO:0006935 9.87 CXCL11 CXCL8 CXCR3 DEFB4A
6 cellular response to lipopolysaccharide GO:0071222 9.86 CXCL11 CXCL8 TLR4
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 TLR2 TLR4 TLR9
8 defense response GO:0006952 9.85 CXCL11 CXCL8 DEFB4A
9 defense response to Gram-positive bacterium GO:0050830 9.83 CRP DEFB4A TLR2
10 defense response to Gram-negative bacterium GO:0050829 9.82 DEFB4A TLR4 TLR9
11 chemokine-mediated signaling pathway GO:0070098 9.81 CXCL11 CXCL8 CXCR3
12 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.8 CXCL11 CXCL8 DEFB4A
13 extracellular matrix disassembly GO:0022617 9.8 MMP1 MMP2 MMP3
14 positive regulation of interleukin-6 production GO:0032755 9.79 TLR2 TLR4 TLR9
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.77 TLR2 TLR4 TLR9
16 positive regulation of tumor necrosis factor production GO:0032760 9.77 TLR2 TLR4 TLR9
17 toll-like receptor signaling pathway GO:0002224 9.73 TLR2 TLR4 TLR9
18 collagen catabolic process GO:0030574 9.72 MMP1 MMP2 MMP3
19 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.71 TLR2 TLR4 TLR9
20 positive regulation of inflammatory response GO:0050729 9.71 ITGA2 TLR2 TLR4 TLR9
21 negative regulation of interleukin-6 production GO:0032715 9.69 TLR4 TLR9
22 positive regulation of interleukin-8 production GO:0032757 9.69 TLR2 TLR4 TLR9
23 leukocyte chemotaxis GO:0030595 9.68 CXCL11 CXCL8
24 positive regulation of protein oligomerization GO:0032461 9.67 MMP1 MMP3
25 positive regulation of interferon-beta production GO:0032728 9.67 TLR2 TLR4 TLR9
26 T cell chemotaxis GO:0010818 9.66 CXCL11 CXCR3
27 cellular response to lipoteichoic acid GO:0071223 9.65 TLR2 TLR4
28 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.65 TLR4 TLR9
29 positive regulation of interleukin-12 production GO:0032735 9.65 TLR2 TLR4 TLR9
30 positive regulation of interferon-beta biosynthetic process GO:0045359 9.64 TLR4 TLR9
31 positive regulation of interleukin-10 production GO:0032733 9.63 TLR2 TLR4 TLR9
32 positive regulation of interleukin-18 production GO:0032741 9.61 TLR2 TLR9
33 tumor necrosis factor production GO:0032640 9.61 TLR2 TLR9
34 positive regulation of chemokine production GO:0032722 9.61 TLR2 TLR4 TLR9
35 positive regulation of toll-like receptor signaling pathway GO:0034123 9.58 TLR2 TLR9
36 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.54 TLR2 TLR4 TLR9
37 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.52 TLR2 TLR4
38 regulation of cytokine secretion GO:0050707 9.5 TLR2 TLR4 TLR9
39 immune response GO:0006955 9.5 CXCL11 CXCL8 CXCR3 DEFB4A TLR2 TLR4
40 I-kappaB phosphorylation GO:0007252 9.43 TLR2 TLR4 TLR9
41 response to molecule of bacterial origin GO:0002237 9.33 CXCL8 TLR2 TLR9
42 inflammatory response GO:0006954 9.17 CRP CXCL11 CXCL8 CXCR3 TLR2 TLR4
43 signal transduction GO:0007165 10.17 CXCL11 CXCL8 CXCR3 TLR2 TLR4 TLR9

Molecular functions related to Septic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metallopeptidase activity GO:0008237 9.43 MMP1 MMP2 MMP3
2 metalloendopeptidase activity GO:0004222 9.33 MMP1 MMP2 MMP3
3 signaling pattern recognition receptor activity GO:0008329 8.96 TLR2 TLR9
4 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Septic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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