MCID: SPT004
MIFTS: 60

Septic Arthritis

Categories: Blood diseases, Bone diseases, Infectious diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Septic Arthritis

MalaCards integrated aliases for Septic Arthritis:

Name: Septic Arthritis 12 54 15
Infectious Arthritis 12 77 54 44 17
Arthritis, Infectious 45 74
Arthritis, Bacterial 74
Arthritis Septic 56

Classifications:



Summaries for Septic Arthritis

MedlinePlus : 44 Most kinds of arthritis cause pain and swelling in your joints. Joints are places where two bones meet, such as your elbow or knee. Infectious arthritis is an infection in the joint. The infection comes from a bacterial, viral, or fungal infection that spreads from another part of the body. Symptoms of infectious arthritis include Intense pain in the joint Joint redness and swelling Chills and fever Inability to move the area with the infected joint One type of infectious arthritis is reactive arthritis. The reaction is to an infection somewhere else in your body. The joint is usually the knee, ankle, or toe. Sometimes, reactive arthritis is set off by an infection in the bladder, or in the urethra, which carries urine out of the body. In women, an infection in the vagina can cause the reaction. For both men and women, it can start with bacteria passed on during sex. Another form of reactive arthritis starts with eating food or handling something that has bacteria on it. To diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. Treatment includes medicines and sometimes surgery.

MalaCards based summary : Septic Arthritis, also known as infectious arthritis, is related to haemophilus influenzae and endocarditis, and has symptoms including fever, pruritus and back pain. An important gene associated with Septic Arthritis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Integrin Pathway and Degradation of the extracellular matrix. The drugs Hyaluronic acid and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and testes, and related phenotypes are cardiovascular system and neoplasm

Disease Ontology : 12 An arthritis that involves infection by a pathogen located in joint.

NIH Rare Diseases : 54 Infectious arthritis is joint pain, soreness, stiffness and swelling caused by a bacterial, viral, or fungal infection that spreads from another part of the body. Depending on the type of infection, one or more joints may be affected. Certain bacteria can cause a form of infectious arthritis called reactive arthritis, which appears to be caused by the immune system reacting to bacteria, rather than by the infection itself. In reactive arthritis, joint inflammation develops weeks, months or even years after the infection. Reactive arthritis happens most commonly after infections of the genital and gastrointestinal tracts. To diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. Treatment includes medicines and sometimes surgery.

Wikipedia : 77 Septic arthritis, also known as joint infection or infectious arthritis, is the invasion of a joint by... more...

Related Diseases for Septic Arthritis

Diseases related to Septic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 285)
# Related Disease Score Top Affiliating Genes
1 haemophilus influenzae 31.0 CXCL8 TLR2
2 endocarditis 30.8 CRP CXCL8 TLR2
3 synovitis 30.7 CRP CXCL8 MMP3
4 mycobacterium kansasii 30.7 CXCL8 TLR2
5 mycobacterium marinum 30.6 CXCL8 TLR2
6 rheumatoid arthritis 30.5 CRP CXCL8 MMP3 TLR2 TLR4
7 otitis media 30.4 CXCL8 TLR2 TLR4
8 meningitis 30.4 CRP CXCL8 TLR2
9 mycobacterium abscessus 30.2 CXCL8 TLR2
10 prosthetic joint infection 30.2 TLR2 TLR4
11 bone inflammation disease 30.2 CRP CXCL8 MMP3
12 pneumonia 30.1 CRP CXCL8 TLR2 TLR4
13 brucellosis 30.1 CRP CXCL8 TLR4
14 acute cystitis 30.1 CRP CXCL8
15 discitis 30.1 CALCA CRP
16 pyelonephritis 30.0 CRP CXCL8 TLR4
17 spondyloarthropathy 1 29.9 CRP MMP3 TLR4
18 acute cholangitis 29.8 CALCA CRP
19 toxic shock syndrome 29.8 CXCL8 TLR2 TLR4
20 bacterial meningitis 29.8 CRP CXCL8 TLR2
21 chorioamnionitis 29.8 CRP CXCL8 TLR4
22 peritonitis 29.8 CRP CXCL8 TLR2
23 chlamydia 29.5 CRP CXCL8 TLR2 TLR4
24 bacterial infectious disease 29.2 CRP CXCL8 DEFB4A TLR2 TLR4
25 pyoderma gangrenosum 28.9 CXCL8 MMP10
26 arthritis 11.4
27 ophthalmia neonatorum 11.2
28 shigellosis 11.0
29 osteomyelitis 10.9
30 trench fever 10.4 TLR2 TLR4
31 fungal keratitis 10.4 TLR2 TLR4
32 acute cervicitis 10.4 TLR2 TLR4
33 dental abscess 10.4 CRP TLR4
34 penicilliosis 10.4 TLR2 TLR4
35 myositis fibrosa 10.4 TLR2 TLR4
36 gout 10.3
37 spondylarthropathy 10.3 TLR2 TLR4
38 systemic lupus erythematosus 10.3
39 pyomyositis 10.3
40 lupus erythematosus 10.3
41 mesenteric lymphadenitis 10.3 CRP TLR2
42 neisseria meningitidis infection 10.3 TLR2 TLR4
43 mycobacterium chelonae 10.3 CXCL8 TLR2
44 spastic entropion 10.3 MMP2 MMP3
45 lipid pneumonia 10.3 CRP CXCR3
46 neurosyphilis 10.3 CXCL8 TLR2
47 myasthenic syndrome, congenital, 1a, slow-channel 10.3 CRP CXCL8
48 mycoplasma pneumoniae pneumonia 10.3 CRP TLR2
49 pouchitis 10.3 CXCL8 TLR4
50 alveolar echinococcosis 10.3 TLR2 TLR4

Comorbidity relations with Septic Arthritis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Septic Arthritis:



Diseases related to Septic Arthritis

Symptoms & Phenotypes for Septic Arthritis

UMLS symptoms related to Septic Arthritis:


fever, pruritus, back pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Septic Arthritis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 CRP CXCR3 MMP10 MMP11 MMP2 TLR2
2 neoplasm MP:0002006 9.02 CXCR3 MMP11 MMP2 TLR2 TLR4

Drugs & Therapeutics for Septic Arthritis

Drugs for Septic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4,Not Applicable 9004-61-9 53477741
2
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
3
Vancomycin Approved Phase 4,Phase 3,Not Applicable 1404-90-6 441141 14969
4
Cefazolin Approved Phase 4,Phase 3 25953-19-9 656510 33255
5
Teicoplanin Approved, Investigational Phase 4 61036-62-2
6
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
7
Dalbavancin Approved, Investigational Phase 4 171500-79-1, 91097-81-3 122186
8
Nafcillin Approved, Investigational Phase 4 985-16-0, 147-52-4 8982
9
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
10
Ceftaroline fosamil Approved, Investigational Phase 4 229016-73-3
11
Linezolid Approved, Investigational Phase 4,Phase 3 165800-03-3 441401
12 Viscosupplements Phase 4,Not Applicable
13 Adjuvants, Immunologic Phase 4,Not Applicable
14 Immunologic Factors Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
15 Protective Agents Phase 4,Not Applicable
16 Antibodies Phase 4,Phase 3,Phase 2,Early Phase 1
17 Immunoglobulins, Intravenous Phase 4,Phase 3,Phase 2
18 Immunoglobulins Phase 4,Phase 3,Phase 2,Early Phase 1
19 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
20 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable
21 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
22 gamma-Globulins Phase 4,Phase 3,Phase 2
23 Rho(D) Immune Globulin Phase 4,Phase 3,Phase 2
24 Chlorhexidine gluconate Phase 4
25 Anti-Infective Agents, Local Phase 4
26 Disinfectants Phase 4
27 Dermatologic Agents Phase 4,Phase 3
28 Antitubercular Agents Phase 4,Not Applicable
29 Clindamycin palmitate Phase 4
30 Clindamycin phosphate Phase 4
31
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
32
leucovorin Approved Phase 3 58-05-9 6006 143
33
Amoxicillin Approved, Vet_approved Phase 2, Phase 3,Not Applicable 26787-78-0 33613
34
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
35
tannic acid Approved Phase 3 1401-55-4
36
Proline Approved, Nutraceutical Phase 3 147-85-3 145742
37
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
38 Pharmaceutical Solutions Phase 3
39 Immunoglobulin G Phase 3,Phase 2
40 Antimetabolites Phase 3
41 Vitamin B Complex Phase 3
42 Immunosuppressive Agents Phase 3
43 Antimetabolites, Antineoplastic Phase 3
44 Nucleic Acid Synthesis Inhibitors Phase 3
45 Vitamin B9 Phase 3
46 Folate Phase 3
47 Antirheumatic Agents Phase 3
48 Folic Acid Antagonists Phase 3
49
Cephalexin Approved, Investigational, Vet_approved Phase 1 15686-71-2 27447
50
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616

Interventional clinical trials:

(show top 50) (show all 52)
# Name Status NCT ID Phase Drugs
1 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
2 Safety and Efficacy Study of Flebogamma 5% DIF IGIV in Pediatric Subjects Completed NCT00634569 Phase 4
3 Post-Operative Colonization Rates of Femoral Nerve Catheters Treated With Chlorhexidine-Impregnated Patch Completed NCT01411891 Phase 4
4 Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
5 Antibiotics Usage in Pediatric Orthopaedic Percutaneous Surgery (APOPS) Recruiting NCT03261830 Phase 4 Cefazolin;Clindamycin;Saline
6 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
7 Efficacy and Safety Study of Kedrion IVIG 10% to Treat Subjects With Primary Immunodeficiency (PID) Unknown status NCT01581593 Phase 3
8 Open Label, Phase III Study of NABI-IGIV 10% [Immune Globulin Intravenous(Human), 10%] In Subjects With Primary Immune Deficiency Disorders (PIDD) Completed NCT00538915 Phase 3
9 A Study of NewGam, Human Immunoglobulin 10%, in Patients With Primary Immunodeficiency Diseases Completed NCT01012323 Phase 3
10 Immune Globulin Subcutaenous (Human), 20% Completed NCT01412385 Phase 2, Phase 3
11 Extension Study of Subcutaneous Immunoglobulin Human in Patients With Primary Immunodeficiency (PID) Completed NCT00719680 Phase 3
12 Study of Subcutaneous Immunoglobulin in Patients With PID Requiring IgG Replacement Therapy Completed NCT00419341 Phase 3
13 Gammagard Liquid and rHuPH20 in PID Completed NCT00814320 Phase 3
14 Multicenter Study of Long-Term Clinical Outcomes of Subcutaneous Immune Globulin IgPro20 in Subjects With Primary Immunodeficiency (Japan Study) Completed NCT01461018 Phase 3
15 Safety and Efficacy of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID) Completed NCT00322556 Phase 3 Immunoglobulins Intravenous (Human)
16 Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy Completed NCT00542997 Phase 3
17 Follow-up Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (Japan Study) Completed NCT01458171 Phase 3
18 Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (EU Extension Study) Completed NCT00751621 Phase 3
19 A Study to Evaluate Efficacy of Tocilizumab Administered as Monotherapy or in Combination With Methotrexate and/or Other Disease Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis (RA) Participants Completed NCT01941940 Phase 3 Tocilizumab;DMARDs
20 Twice Daily Treatment With Amoxicillin for Non-severe Community Acquired Pneumonia. Recruiting NCT03031210 Phase 2, Phase 3 Amoxicillin
21 Study of Octanorm Subcutaneous IG in Patients With PID Active, not recruiting NCT01888484 Phase 3
22 Study of Immune Globulin Intravenous (Human) GC5101F in Subjects With Primary Humoral Immunodeficiency Not yet recruiting NCT03492710 Phase 3
23 Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections Terminated NCT00108433 Phase 3 Cefazolin IV;Linezolid IV;Vancomycin (IV)
24 Surgical Lavage vs Serial Needle Aspiration for Infected Joints Withdrawn NCT00313365 Phase 3
25 Cefadroxil and Cephalexin Drug Levels and Dosing in Pediatric Musculoskeletal Infections Not yet recruiting NCT03802552 Phase 1 Cefadroxil;Cephalexin
26 Arthrocentesis Study Unknown status NCT02530229
27 Analysis of Human Knee Joint Fluid Using Metabonomic, Genomic and Tribology Techniques Unknown status NCT02565160
28 Personalized Immunotherapeutic for Antibiotic-resistant Infection Unknown status NCT02508584 Early Phase 1
29 Ultrasonography Assessment of Septic Arthritis on Native Joint Completed NCT02018952 Not Applicable
30 Pro-calcitonin for Early Detection of Septic Arthritis Completed NCT02085733
31 Use of Infrared Spectroscopy in Septic Arthritis Diagnosis Completed NCT02860871
32 Determination of New Biomarkers of Septic Arthritis by Surface-Enhanced Laser Desorption/Ionization Time-Of-Flight (SELDI-TOF) Completed NCT01010165
33 ARTEMIS Synovial Markers in Arthritis Childhood Completed NCT02505828 Not Applicable
34 Molecular Microbiology in Osteo-arthritis Infection Completed NCT01193803
35 Two Versus Four Weeks of Antibiotic Treatment in Native Joint Arthritis Completed NCT03615781 Not Applicable Two week's arm - drugs;Four week's arm - drugs
36 The Application of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Sepsis & Relevant Acute Kidney Injuries Completed NCT01333657
37 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Completed NCT00933296
38 Irrigation Versus no Irrigation for Cutaneous Abscess Completed NCT01606657 Not Applicable
39 Procalcitonin Level and Kinetics in Children With Bacterial Infections Completed NCT00714402
40 Efficacy of OSTENIL PLUS (Hyaluronic Acid) Versus SYNVISC-ONE in Patients With Tibiofemoral Osteoarthritis Completed NCT03203408 Not Applicable
41 Alpha-Defensin and Synovial Proteins to Improve Detection of Pediatric Septic Arthritis Recruiting NCT03704766 Not Applicable
42 External Validation of a Septic Arthritis Prognosis Score Recruiting NCT03819855
43 Differentiate Children Septic and Inflammatory Arthritis by Comparative Analysis Recruiting NCT03827759
44 Long- and Midterm Outcomes of Osteoarticular Infections in Paediatric Patients Recruiting NCT03827980
45 Operative and Non-operative Treatment of Traumatic Arthrotomies Recruiting NCT02841644
46 Osteoarticular Infections With Pneumococcal Recruiting NCT03852784
47 Safety Study of Univers® Revers Shoulder Prosthesis Active, not recruiting NCT01778777 Not Applicable
48 Ankle Joint Replacement Outcomes Study Active, not recruiting NCT00503438 Not Applicable
49 Short 3-week Antibiotic Treatment Versus 6 Weeks in Adults With Septic Arthritis of Native Joint Not yet recruiting NCT03716921 Not Applicable
50 Next-Generation Sequencing for Pathogen Detection and Quantification in Children With Musculoskeletal Infections Not yet recruiting NCT03846804

Search NIH Clinical Center for Septic Arthritis

Cochrane evidence based reviews: arthritis, infectious

Genetic Tests for Septic Arthritis

Anatomical Context for Septic Arthritis

The Foundational Model of Anatomy Ontology organs/tissues related to Septic Arthritis:

20
Joint

MalaCards organs/tissues related to Septic Arthritis:

42
Bone, Testes, Kidney, Colon, Myeloid, Skin, Neutrophil

Publications for Septic Arthritis

Articles related to Septic Arthritis:

(show top 50) (show all 2421)
# Title Authors Year
1
Septic Arthritis of the Native Ankle. ( 30889008 )
2019
2
Candida glabrata-Induced Refractory Infectious Arthritis: A Case Report and Literature Review. ( 30903581 )
2019
3
Calcium pyrophosphate dihydrate crystal deposition disease and MRSA septic arthritis of the atlantoaxial joint in a patient with Tourette syndrome. ( 30904893 )
2019
4
Patients with a History of Treated Septic Arthritis are at High Risk of Periprosthetic Joint Infection after Total Joint Arthroplasty. ( 30913112 )
2019
5
Evaluation and Management of Septic Arthritis and its Mimics in the Emergency Department. ( 30881554 )
2019
6
The predictive value of synovial glucose level in septic arthritis. ( 30882559 )
2019
7
Factors associated with septic arthritis of the distal interphalangeal joint in beef cattle: A case-control study. ( 30825885 )
2019
8
Surgical management of sternoclavicular joint septic arthritis. ( 30828216 )
2019
9
Broad-range 16 s rDNA PCR in synovial fluid does not improve the diagnostic performance of septic arthritis in native joints in adults: cross-sectional single-center study in 95 patients. ( 30850963 )
2019
10
A nationwide analysis of failed irrigation and debridement for pediatric septic arthritis of the hip. ( 30855548 )
2019
11
Performance of automated multiplex polymerase chain reaction (mPCR) using synovial fluid in the diagnosis of native joint septic arthritis in adults. ( 30813795 )
2019
12
Native Joint Septic Arthritis due to Clostridium tarantellae. ( 30753899 )
2019
13
Effects of Antibiotics on α-Toxin Levels during Staphylococcus aureus Culture: Implications for the Protection of Chondrocytes in a Model of Septic Arthritis. ( 30762428 )
2019
14
The Incidence of Pin Tract Infections and Septic Arthritis in Percutaneous Distal Femur Pinning. ( 30762618 )
2019
15
Septic Arthritis Following Radiofrequency Ablation of the Genicular Nerves. ( 30698785 )
2019
16
The role of real-time PCR testing in the investigation of paediatric patients with community-onset osteomyelitis and septic arthritis. ( 30706296 )
2019
17
Can C-Reactive Protein Be Used to Predict Acute Septic Arthritis in the Adult Population? ( 30708377 )
2019
18
Moraxella nonliquefaciens septic arthritis in a hematopoietic stem cell transplant patient a case report and review of the literature. ( 30711347 )
2019
19
Septic arthritis caused by Salmonella enterica serotype Rubislaw: A case report. ( 30652794 )
2019
20
Septic arthritis of the hip and knee treated surgically in pediatric patients: Analysis of the Kids' Inpatient Database. ( 30655655 )
2019
21
Vancomycin-soaking of the graft reduces the incidence of septic arthritis following ACL reconstruction: results of a systematic review and meta-analysis. ( 30656372 )
2019
22
Use of standard diagnostic techniques to determine eradication of infection in experimental equine septic arthritis. ( 30670899 )
2019
23
Clinical Characteristics and Long-term Outcomes After Septic Arthritis of the Native Glenohumeral Joint: A 20-Year Retrospective Review. ( 30602050 )
2019
24
Medical Versus Surgical Approach to Initial Treatment in Septic Arthritis: A Single Spanish Center's 8-Year Experience. ( 29215382 )
2019
25
Bacteremia and Septic Arthritis due to a Nontoxigenic Strain of<i>Clostridium difficile</i>in a Patient With Sickle Cell Disease. ( 29410974 )
2018
26
Acute septic arthritis of the knee: A rare case report of infection with Parvimonas micra after an intra-articular corticosteroid injection for osteoarthritis. ( 29305995 )
2018
27
Increased Mortality and Reoperation Rates After Treatment for Septic Arthritis of the Knee in People Who Inject Drugs: Nationwide Inpatient Sample, 2000-2013. ( 29762153 )
2018
28
Incidental diagnosis of sternoclavicular septic arthritis with <i>Moraxella nonliquefaciens</i>. ( 29942746 )
2018
29
Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of <i>Staphylococcus aureus</i>-Induced Septic Arthritis. ( 29867945 )
2018
30
Arthroscopic debridement for septic arthritis of the shoulder joint: post-infectious arthritis is an inevitable consequence? ( 29777344 )
2018
31
Validating an Algorithm to Predict Adjacent Musculoskeletal Infections in Pediatric Patients With Septic Arthritis. ( 29389760 )
2018
32
Host Factors Affect the Outcome of Arthroscopic Lavage Treatment of Septic Arthritis of the Knee. ( 29309715 )
2018
33
Long-term results of bacterial septic arthritis of the wrist. ( 29891427 )
2018
34
Factors Related to Surgical Treatment and Outcomes of Thai Patients With Septic Arthritis. ( 29912769 )
2018
35
Pyomyositis presenting as septic arthritis. ( 29559212 )
2018
36
Suture-induced arthritis as a clinical mimicker of septic arthritis. ( 29445456 )
2018
37
Septic arthritis caused by Granulicatella adiacens after anterior cruciate ligament reconstruction. ( 29422445 )
2018
38
Disseminated Exophiala dermatitidis causing septic arthritis and osteomyelitis. ( 29866071 )
2018
39
Bilateral septic arthritis of the sternoclavicular joint complicating infective endocarditis: a case report. ( 29973288 )
2018
40
Septic Arthritis of the Wrist. ( 29329124 )
2018
41
Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton. ( 29396671 )
2018
42
Atypical Mycobacterial Septic Arthritis of the Wrist: A Report of Two Cases. ( 29952776 )
2018
43
Current clinical and bacteriological profile of septic arthritis in young infants: a prospective study from a tertiary referral centre. ( 29427091 )
2018
44
Septic arthritis due to oral streptococci following intra-articular injection: A case series. ( 29805059 )
2018
45
Radiographic Study of Haematogenous Septic Arthritis in Dairy Calves. ( 29908523 )
2018
46
Isolated septic arthritis of hip joint: a rare presentation of melioidosis. A case report. ( 29351806 )
2018
47
Group B streptococcus septic arthritis of the hip following spontaneous abortion. ( 29326375 )
2018
48
Septic Arthritis, Osteomyelitis, and Pyomyositis in a Previously Healthy Infant. ( 29293205 )
2018
49
Neutralization of TNFR-1 and TNFR-2 modulates S. aureus induced septic arthritis by regulating the levels of pro inflammatory and anti inflammatory cytokines during the progression of the disease. ( 29339199 )
2018
50
Acute septic arthritis of shoulder joint caused by Aeromonas veronii biotype sobria. ( 29872872 )
2018

Variations for Septic Arthritis

Expression for Septic Arthritis

Search GEO for disease gene expression data for Septic Arthritis.

Pathways for Septic Arthritis

Pathways related to Septic Arthritis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 CXCL8 CXCR3 ITGA2 MMP10 MMP11 MMP2
2
Show member pathways
12.53 ITGA2 MMP10 MMP11 MMP2 MMP3
3
Show member pathways
12.17 CXCL8 DEFB4A MMP3 TLR2
4 12.11 ITGA2 MMP2 TLR2 TLR4
5
Show member pathways
12.06 CXCL8 TLR2 TLR4
6 11.96 ITGA2 TLR2 TLR4
7
Show member pathways
11.95 CXCL8 DEFB4A TLR2 TLR4
8 11.92 MMP11 MMP2 TLR2 TLR4
9 11.82 CXCL8 MMP2 MMP3
10 11.73 CXCL8 TLR2 TLR4
11 11.67 ITGA2 TLR2 TLR4
12
Show member pathways
11.62 MMP10 MMP11 MMP2 MMP3
13 11.53 CALCA CXCL8 MMP2
14
Show member pathways
11.53 MMP10 MMP11 MMP2 MMP3 TLR2 TLR4
15
Show member pathways
11.52 CXCL8 MMP2 MMP3
16 11.52 CXCL8 MMP3 TLR2 TLR4
17 11.44 CXCL8 TLR2 TLR4
18
Show member pathways
11.38 CXCL8 CXCR3 ITGA2 MMP10 MMP11 MMP2
19 11.36 CXCL8 TLR2 TLR4
20 11.24 CXCL8 MMP10 MMP2 MMP3
21 11.15 CXCL8 MMP2
22 11.12 MMP2 TLR4
23 11.06 CXCL8 ITGA2 MMP2
24 10.87 CRP CXCL8

GO Terms for Septic Arthritis

Cellular components related to Septic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CALCA CRP CXCL8 DEFB4A MMP10 MMP2
2 extracellular matrix GO:0031012 9.46 MMP10 MMP11 MMP2 MMP3
3 extracellular region GO:0005576 9.23 CALCA CRP CXCL8 DEFB4A MMP10 MMP11

Biological processes related to Septic Arthritis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.8 CXCL8 CXCR3 DEFB4A TLR2 TLR4
2 chemotaxis GO:0006935 9.73 CXCL8 CXCR3 DEFB4A
3 defense response to Gram-positive bacterium GO:0050830 9.65 CRP DEFB4A TLR2
4 positive regulation of inflammatory response GO:0050729 9.61 ITGA2 TLR2 TLR4
5 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.6 TLR2 TLR4
6 positive regulation of interferon-beta production GO:0032728 9.59 TLR2 TLR4
7 positive regulation of interleukin-12 production GO:0032735 9.58 TLR2 TLR4
8 negative regulation of osteoclast differentiation GO:0045671 9.58 CALCA TLR4
9 positive regulation of interleukin-10 production GO:0032733 9.57 TLR2 TLR4
10 extracellular matrix disassembly GO:0022617 9.56 MMP10 MMP11 MMP2 MMP3
11 positive regulation of chemokine production GO:0032722 9.55 TLR2 TLR4
12 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.54 TLR2 TLR4
13 regulation of cytokine secretion GO:0050707 9.52 TLR2 TLR4
14 I-kappaB phosphorylation GO:0007252 9.51 TLR2 TLR4
15 positive regulation of interleukin-8 production GO:0032757 9.5 CALCA TLR2 TLR4
16 response to molecule of bacterial origin GO:0002237 9.49 CXCL8 TLR2
17 cellular response to lipoteichoic acid GO:0071223 9.46 TLR2 TLR4
18 inflammatory response GO:0006954 9.43 CALCA CRP CXCL8 CXCR3 TLR2 TLR4
19 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.37 TLR2 TLR4
20 response to hypoxia GO:0001666 9.33 ITGA2 MMP2 TLR2
21 collagen catabolic process GO:0030574 8.92 MMP10 MMP11 MMP2 MMP3

Molecular functions related to Septic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.62 MMP10 MMP11 MMP2 MMP3
2 serine-type endopeptidase activity GO:0004252 9.56 MMP10 MMP11 MMP2 MMP3
3 lipopolysaccharide binding GO:0001530 9.37 TLR2 TLR4
4 metallopeptidase activity GO:0008237 9.26 MMP10 MMP11 MMP2 MMP3
5 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
6 metalloendopeptidase activity GO:0004222 8.92 MMP10 MMP11 MMP2 MMP3

Sources for Septic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....