Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: SPT004
MIFTS: 58

Septic Arthritis

Categories: Blood diseases, Bone diseases, Infectious diseases, Nephrological diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Septic Arthritis

About this section

MalaCards integrated aliases for Septic Arthritis:

Name: Septic Arthritis 12 52 15
Infectious Arthritis 12 74 52 42 17
Arthritis, Infectious 43 71
Arthritis, Bacterial 71
Arthritis Septic 54

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Bone diseases Nephrological diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:813
MeSH 43 D001170
NCIt 49 C26700
SNOMED-CT 67 396234004 428437005
ICD10 32 M00
UMLS 71 C0003869 C0157843 C0157844 more
Sources

Summaries for Septic Arthritis

About this section
MedlinePlus : 42 Most kinds of arthritis cause pain and swelling in your joints. Joints are places where two bones meet, such as your elbow or knee. Infectious arthritis is an infection in the joint. The infection comes from a bacterial, viral, or fungal infection that spreads from another part of the body. Symptoms of infectious arthritis include Intense pain in the joint Joint redness and swelling Chills and fever Inability to move the area with the infected joint One type of infectious arthritis is reactive arthritis. The reaction is to an infection somewhere else in your body. The joint is usually the knee, ankle, or toe. Sometimes, reactive arthritis is set off by an infection in the bladder, or in the urethra, which carries urine out of the body. In women, an infection in the vagina can cause the reaction. For both men and women, it can start with bacteria passed on during sex. Another form of reactive arthritis starts with eating food or handling something that has bacteria on it. To diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. Treatment includes medicines and sometimes surgery.

MalaCards based summary : Septic Arthritis, also known as infectious arthritis, is related to shigellosis and arthritis, and has symptoms including fever, pruritus and back pain. An important gene associated with Septic Arthritis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Hyaluronic acid and Amphotericin B have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An arthritis that involves infection by a pathogen located in joint.

NIH Rare Diseases : 52 Infectious arthritis is joint pain, soreness, stiffness and swelling caused by a bacterial, viral, or fungal infection that spreads from another part of the body. Depending on the type of infection, one or more joints may be affected. Certain bacteria can cause a form of infectious arthritis called reactive arthritis , which appears to be caused by the immune system reacting to bacteria, rather than by the infection itself. In reactive arthritis, joint inflammation develops weeks, months or even years after the infection. Reactive arthritis happens most commonly after infections of the genital and gastrointestinal tracts. To diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. Treatment includes medicines and sometimes surgery.

Wikipedia : 74 Septic arthritis, also known as joint infection or infectious arthritis, is the invasion of a joint by... more...

Sources

Related Diseases for Septic Arthritis

About this section

Diseases related to Septic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 591)
# Related Disease Score Top Affiliating Genes
1 shigellosis 32.3 TLR5 TLR4 CXCL8
2 arthritis 31.7 TLR4 TLR2 MMP3 MMP1 IFNG CXCL8
3 haemophilus influenzae 31.7 TLR2 CXCL8
4 osteomyelitis 31.7 TLR4 TLR2 IFNG CXCL8 CALCA
5 endocarditis 31.4 TLR2 IFNG CXCL8 CRP
6 synovitis 31.4 MMP3 MMP1 CXCL8 CRP
7 prosthetic joint infection 31.3 TLR4 TLR2 CRP
8 infective endocarditis 31.2 TREM1 TLR2 CRP
9 mycobacterium kansasii 31.2 TLR2 CXCL8
10 mycobacterium marinum 31.1 TLR2 CXCL8
11 cellulitis 31.1 IFNG DEFB4A CRP
12 exanthem 31.0 IFNG CXCL8 CRP
13 arthropathy 30.9 MMP3 MMP2 MMP1 IFNG CRP
14 osteoarthritis 30.9 MMP3 MMP1 CXCL8 CRP
15 endophthalmitis 30.9 TLR2 CXCL8 CRP
16 lyme disease 30.9 TLR9 TLR2 CRP
17 toxic shock syndrome 30.8 TREM1 TLR4 TLR2 IFNG CXCL8 CRP
18 brucellosis 30.8 TLR4 IFNG CXCL8 CRP
19 juvenile rheumatoid arthritis 30.7 MMP3 IFNG CXCL8 CRP
20 acute cystitis 30.7 TLR5 TLR4 TLR2 CXCL8 CRP
21 melioidosis 30.7 TREM1 TLR5 TLR4 TLR2 IFNG
22 reactive arthritis 30.7 TLR4 TLR2 IFNG CXCL8 CRP
23 pericarditis 30.6 IFNG CXCL8 CRP
24 typhoid fever 30.6 TLR5 TLR4 IFNG CRP
25 sarcoidosis 1 30.6 IFNG CXCR3 CRP CCL18
26 fasciitis 30.6 MMP1 IFNG CXCL8 CRP
27 discitis 30.5 CRP CALCA
28 spondyloarthropathy 1 30.5 TLR4 MMP3 CRP
29 granulomatosis with polyangiitis 30.5 TLR9 TLR4 TLR2 CRP
30 otitis media 30.5 TLR5 TLR4 TLR2 IFNG CXCL8 CRP
31 conjunctivitis 30.4 TLR3 IFNG CXCL8
32 familial mediterranean fever 30.4 TLR4 TLR2 CXCL8 CRP
33 chickenpox 30.4 TLR9 TLR3 TLR2 IFNG CRP
34 peritonitis 30.4 TLR4 TLR2 IFNG CXCL8 CRP
35 meningococcal meningitis 30.3 TLR9 TLR4 TLR2
36 crohn's colitis 30.3 IFNG DEFB4A CXCL8
37 neutropenia 30.3 TLR4 IFNG CXCL8 CRP
38 mycobacterium abscessus 30.3 TLR2 CXCL8
39 gastroenteritis 30.3 TLR9 IFNG CXCL8 CRP CALCA
40 ileitis 30.3 TLR5 TLR4 TLR2
41 lepromatous leprosy 30.2 TLR2 IFNG CCL18
42 autoimmune disease 30.2 TLR9 IFNG CXCR3 CXCL8 CRP
43 appendicitis 30.2 TLR4 MMP3 IFNG CXCL8 CRP
44 meningitis 30.2 TLR9 TLR4 TLR2 IFNG CXCL8 CRP
45 pyelonephritis 30.2 TLR4 IFNG CXCL8 CRP CALCA
46 neurogenic arthropathy 30.2 CRP CALCA
47 pyoderma 30.2 MMP1 CXCL8 CRP
48 herpes zoster 30.2 TLR2 IFNG CRP
49 acute cholangitis 30.2 TREM1 CRP CALCA
50 acute pyelonephritis 30.2 IFNG CXCL8 CRP CALCA

Comorbidity relations with Septic Arthritis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Septic Arthritis:



Diseases related to Septic Arthritis
Sources

Symptoms & Phenotypes for Septic Arthritis

About this section

UMLS symptoms related to Septic Arthritis:


fever, pruritus, back pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Septic Arthritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 CXCR3 IFNG ITGA2 MMP2 MMP3 MMP7
2 homeostasis/metabolism MP:0005376 10.13 CRP CXCR3 IFNG ITGA2 MMP1 MMP2
3 cardiovascular system MP:0005385 10.07 CRP CXCR3 IFNG MMP2 MMP7 RELA
4 immune system MP:0005387 10 CRP CXCR3 IFNG MMP1 MMP2 MMP3
5 neoplasm MP:0002006 9.61 CXCR3 IFNG MMP1 MMP2 MMP7 TLR2
6 respiratory system MP:0005388 9.23 CXCR3 IFNG MMP2 RELA TLR2 TLR3
Sources

Drugs & Therapeutics for Septic Arthritis

About this section

Drugs for Septic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 109)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2
Amphotericin B Approved, Investigational Phase 4 1397-89-3 5280965 14956
3
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
4
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
5
Cloxacillin Approved, Investigational, Vet_approved Phase 4 61-72-3 6098
6
Dalbavancin Approved, Investigational Phase 4 171500-79-1, 91097-81-3 122186
7
Fosfomycin Approved Phase 4 23155-02-4 446987
8
Vancomycin Approved Phase 4 1404-90-6 14969 441141
9
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
10
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
11 Immunologic Factors Phase 4
12 Adjuvants, Immunologic Phase 4
13 Viscosupplements Phase 4
14 Amebicides Phase 4
15 Pharmaceutical Solutions Phase 4
16 Antifungal Agents Phase 4
17 Liposomal amphotericin B Phase 4
18
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
19
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
20
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
21
Zoledronic Acid Approved Phase 2, Phase 3 118072-93-8 68740
22
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
23 Prednisolone acetate Approved, Vet_approved Phase 2, Phase 3 52-21-1
24
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
25 Antibodies Phase 3
26 Immunoglobulins Phase 3
27 Rho(D) Immune Globulin Phase 3
28 Immunoglobulins, Intravenous Phase 3
29 gamma-Globulins Phase 3
30 Protective Agents Phase 2, Phase 3
31 Anti-Inflammatory Agents Phase 2, Phase 3
32 Antineoplastic Agents, Hormonal Phase 2, Phase 3
33 Methylprednisolone Acetate Phase 2, Phase 3
34 Hormone Antagonists Phase 2, Phase 3
35 glucocorticoids Phase 2, Phase 3
36 Antiemetics Phase 2, Phase 3
37 Neuroprotective Agents Phase 2, Phase 3
38 Gastrointestinal Agents Phase 2, Phase 3
39 Diphosphonates Phase 2, Phase 3
40 Antibiotics, Antitubercular Phase 3
41 Antitubercular Agents Phase 3
42
Tedizolid phosphate Approved Phase 2 856867-55-5
43
Tedizolid Approved, Investigational Phase 2 856866-72-3
44
Clindamycin Approved, Vet_approved Phase 2 18323-44-9 29029
45
Rifampicin Approved Phase 2 13292-46-1 5381226 5458213
46
Ceftriaxone Approved Phase 2 73384-59-5 5361919 5479530
47
Cefazolin Approved Phase 2 25953-19-9 656510 33255
48
Nafcillin Approved, Investigational Phase 2 985-16-0, 147-52-4 8982
49
Ciprofloxacin Approved, Investigational Phase 2 85721-33-1 2764
50
Levofloxacin Approved, Investigational Phase 2 100986-85-4 149096

Interventional clinical trials:

(show top 50) (show all 89)
# Name Status NCT ID Phase Drugs
1 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
2 Randomized Open Label Study of Oral Versus Intravenous Antibiotic Treatment for Bone and Joint Infections Requiring Prolonged Antibiotic Treatment: Multi-centre Study Completed NCT00974493 Phase 4 Antibiotics
3 The Use of Antifungal Lock Therapy in Intestinal Failure and Other Patients Completed NCT00936910 Phase 4 amphotericin B liposomal (Ambisome)
4 Ceftriaxone as Home Intravenous Therapy for Deep-Seated Staphylococcal Infections, a Randomized Non-Inferiority Trial Recruiting NCT04141787 Phase 4 Ceftriaxone;Usual Antibiotics (Cloxacillin, Cefazolin, Daptomycin)
5 Dalbavancin For The Treatment Of Gram Positive Osteomyelitis Or Joint Infections Including Prosthetic Hip Or Knee Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
6 Efficacy and Safety of Intravenous Fosfomycin in Prosthetic Joint Infection (PJI) Caused by Staphylococci, Streptococci, Enterococci and Gram-negative Bacilli, Including Mixed Infections and Culture Negative PJI's ("PROOF-Study") Recruiting NCT03260010 Phase 4 Fosfomycin
7 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
8 Ceftaroline in the Treatment of Bone and Joint Infections Withdrawn NCT02005068 Phase 4 Ceftaroline
9 An Open-Label, Non-Randomized, Single-Arm, Multi-Center Study to Evaluate Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections in Subjects for Whom Chronic Antibiotic Suppressive Therapy is Indicated Completed NCT02569541 Phase 2, Phase 3 sodium fusidate
10 A Phase III, Multicenter, Open-Label Study To Evaluate The Efficacy, Safety, and Pharmacokinetics of Gammaplex® in Primary Immunodeficiency Diseases Completed NCT00278954 Phase 3
11 Zoledronic Acid or Methylprednisolone in the Management of Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus: A Randomized, Double-blind, Placebo Controlled Trial Completed NCT03289338 Phase 2, Phase 3 Zoledronic Acid;Methylprednisolone;Placebos
12 Comparison of the Efficacy of a 7-day Versus 14-day Course of Intravenous Antibiotics in the Treatment of Uncomplicated Neonatal Bacterial Sepsis: a Randomized Controlled Non-inferiority Trial Not yet recruiting NCT03280147 Phase 3 7-day course of antibiotics;14-day course of antibiotics
13 Arthrotomy With Irrigation and Debridement Versus Serial Arthrocentesis as Treatment for Septic Arthritis in Adults Withdrawn NCT00313365 Phase 3
14 Randomised, Placebo Controlled Study to Determine if Aquamin (as AquaCal and AquaPT) Modulates Inflammatory Biomarkers in the Blood of Osteoarthritis and Healthy Subjects Completed NCT01321281 Phase 2
15 Tolerability, Safety, and Efficacy of Tedizolid as Oral Treatment for Bone and Joint Infections Recruiting NCT03009045 Phase 2 Tedizolid
16 Randomized Open-label Active-controlled Study to Assess the Safety, Tolerability, and Efficacy of Afabicin IV/Oral in the Treatment of Patients With Bone or Joint Infection Due to Staphylococcus Active, not recruiting NCT03723551 Phase 2 Afabicin;SOC
17 Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection Terminated NCT01756924 Phase 2 CEM-102;IV or Oral standard of care antibiotics;Rifampin
18 Comparative Pharmacokinetics and Pharmacodynamics (PK/PD) of Cefadroxil and Cephalexin for Pediatric Musculoskeletal (MSK) Infections Enrolling by invitation NCT03802552 Phase 1 Cefadroxil;Cephalexin
19 Early Diagnostics of Septic Arthritis and Periprosthetic Joint Infections With Calorimetry and Polymerase Chain Reaction (PCR) of Synovial Aspirate Fluid Unknown status NCT02530229
20 Causative Diagnosis on Prosthetic Joint Infections: Establishment of a Comprehensive Diagnostic Strategy Unknown status NCT01957228
21 Benefit of Synovial Aspiration and Serological Testing in Two-stage Revision Arthroplasty of Prosthetic Joint Infection Unknown status NCT03038464
22 The Utility of Next-generation Sequencing for the Diagnosis of Periprosthetic Joint Infection Unknown status NCT03200470
23 Efficacy and Safety of Fast-track Treatment for Prosthetic Joint Infection (PJI) Unknown status NCT02372435
24 Investigation of Immunological and Pharmacological Factors for Response to Adalimumab in Rheumatoid Arthritis, With Analysis of CD4 + Follicular Helper T Subpopulations Unknown status NCT03110094
25 ARTEMIS Synovial Markers in Arthritis Childhood Completed NCT02505828
26 Two Versus Four Weeks of Antibiotic Treatment in Native Joint Arthritis Completed NCT03615781 Two week's arm - drugs;Four week's arm - drugs
27 Pro-calcitonin for Early Detection of Septic Arthritis Completed NCT02085733
28 Ultrasonography Assessment of Septic Arthritis on Native Joint: a Descriptive, Exploratory, Prospective, Multicentric Trial Completed NCT02018952
29 LOOP- Long- and Midterm Outcomes of Osteoarticular Infections in Paediatric Patients. Completed NCT03827980
30 Use of Infrared Spectroscopy in Septic Arthritis Diagnosis Completed NCT02860871
31 Personalized Immunotherapeutic for Antibiotic-resistant Infection Completed NCT02508584 Early Phase 1
32 Caractérisation de Nouveaux Biomarqueurs de l'Arthrite Septique Par Technique SELDI-TOF Completed NCT01010165
33 Osteoarticular Infections With Pneumococcal Completed NCT03852784
34 Implant-Associated P. Aeruginosa Bone And Joint Infections : Experience In A Regional Reference Center In France Completed NCT03624855
35 Denosumab Related Osteonecrossi of the Jaw : : an Emergent and Potentially Complex Bone and Joint Infection Completed NCT03808285
36 Necrotizing External Otitis : Study in a Regional Bone and Joint Infection Completed NCT03768635
37 Procalcitonin Level as a Prognostic Marker and Its' Kinetics in Children With Bacterial Infections Completed NCT00714402
38 Evaluation of the Use of Cefoxitin in Combination in Continuous Parenteral Administration in the Treatment of Bone and Joint Infections Completed NCT03848104
39 Subcutaneous Suppressive Antibiotic Therapy for Bone and Joint Infections Completed NCT03403608
40 One-stage Exchange Arthroplasty for Chronic Prosthetic Joint Infections Completed NCT03473392
41 A Retrospective, Blinded Validation Study to Assess the Accuracy of a Host-response Based Diagnostics for Distinguishing Between Bacterial and Viral Etiologies in Pediatric Patients With an Acute Febrile Disease Completed NCT01911143
42 Teicoplanin-based Antimicrobial Therapy in Staphylococcus Aureus Bone and Joint Infection: Tolerance, Efficacy and Experience With Subcutaneous Administration Completed NCT03177369
43 Pristinamycin in the Treatment of MSSA Bone and Joint Infection Completed NCT03177343
44 Pharmacokinetic Variability of Daptomycin During Prolonged Therapy for Bone and Joint Infections Completed NCT03209921
45 Microbiological Epidemiology in Patients Experiencing Microbiological or Clinical Failure Following Reimplantation After a 2-stage Exchange Strategy for Hip or Knee Prosthetic Joint Infection Completed NCT03627000
46 Cost of Failure Following Reimplantation After a 2-stage Exchange Strategy for Hip or Knee Prosthetic Joint Infection Completed NCT03612076
47 Concordance Entre l'échographie du Genou et la Radiographie Standard Dans la détection Des Calcifications Dans le Cadre de la Chondrocalcinose Articulaire Completed NCT00797537
48 A Prospective Study on the Diagnosis, Severity and Prognosis of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Sepsis & Related Complications Completed NCT01333657
49 Bacterial Epidemiology and Empirical Antibiotherapy in Patients With Prosthetic Joint Infection Completed NCT03191292
50 Daptomycin > 6 mg/kg/Day as Salvage Therapy in Patients With Complex Bone and Joint Infection: Cohort Study in a Regionalreference Center Completed NCT03209934

Search NIH Clinical Center for Septic Arthritis

Cochrane evidence based reviews: arthritis, infectious

Sources

Genetic Tests for Septic Arthritis

About this section
Sources

Anatomical Context for Septic Arthritis

About this section

The Foundational Model of Anatomy Ontology organs/tissues related to Septic Arthritis:

19
Joint

MalaCards organs/tissues related to Septic Arthritis:

40
Bone, Testes, Skin, Bone Marrow, Myeloid, Liver, Neutrophil
Sources

Publications for Septic Arthritis

About this section

Articles related to Septic Arthritis:

(show top 50) (show all 5941)
# Title Authors PMID Year
1
Epidemiology and risk factors of Staphylococcus aureus CC398 bone and joint infections. 42
32471442 2020
2
Closed arthrodesis in infected neuropathic ankles using Ilizarov ring fixation. 42
32228076 2020
3
Timing of hip hemiarthroplasty and the influence on prosthetic joint infection. 42
32163456 2020
4
Serum procalcitonin for discrimination between septic and non-septic arthritis. 61 54
18578968 2008
5
Septic arthritis due to extended spectrum beta lactamase producing Klebsiella pneumoniae. 61 54
17433752 2007
6
Test characteristics of C-reactive protein (CRP) for pediatric septic arthritis. 61 54
15105739 2004
7
Assessment of the test characteristics of C-reactive protein for septic arthritis in children. 61 54
12724603 2003
8
Acute septic arthritis of the hip in children in northern Australia. 61 54
12608977 2003
9
Evaluation of leukergy test as an indicator of infection in hip joint in children. 61 54
11218681 2000
10
The painful hip: evaluation of criteria for clinical decision-making. 54 61
10541950 1999
11
Bacterial or crystal-associated arthritis? Discriminating ability of serum inflammatory markers. 61 54
10225388 1998
12
A collagen receptor on Staphylococcus aureus strains isolated from patients with septic arthritis mediates adhesion to cartilage. 61 54
8382334 1993
13
Are Patients With a History of Septic Arthritis Undergoing Total Knee Arthroplasty at Higher Risk for Revision Surgery? A Single-Center Study. 61
32247677 2020
14
Gunshot injuries to the lower extremities: Issues, controversies and algorithm of management. 61
32471684 2020
15
Apolipoprotein C1 in synovial fluid discriminates septic arthritis from rheumatoid arthritis but not from pseudogout. 61
32281009 2020
16
Incidence and treatment costs of severe bacterial infections among people who inject heroin: A cohort study in South London, England. 61
32422537 2020
17
The Heterogeneity of Pediatric Knee Infections: A Retrospective Analysis. 61
32501930 2020
18
Osmotic Nephrosis and Acute Kidney Injury Associated With SGLT2 Inhibitor Use: A Case Report. 61
32387022 2020
19
Case Manifestations and Public Health Response for Outbreak of Meningococcal W Disease, Central Australia, 2017. 61
32568047 2020
20
Performance of a new rapid diagnostic test the lactate/glucose ratio of synovial fluid for the diagnosis of septic arthritis. 61
32234547 2020
21
Which Patients Discharged to Home-Based Outpatient Parenteral Antimicrobial Therapy Are at High Risk of Adverse Outcomes? 61
32523974 2020
22
Neisseria meningitidis serogroup C causing primary polyarthritis in an octogenarian. 61
32532902 2020
23
Acute septic elbow monoarthritis with associated Neisseria gonorrhoeae bacteraemia: an uncommon presentation of an old disease. 61
32487791 2020
24
A Bioinformatic Approach to Utilize a Patient's Antibody-Secreting Cells against Staphylococcus aureus to Detect Challenging Musculoskeletal Infections. 61
32571786 2020
25
Graft-Preserving Arthroscopic Debridement With Hardware Removal Is Effective for Septic Arthritis After Anterior Cruciate Ligament Reconstruction: A Clinical, Arthrometric, and Magnetic Resonance Imaging Evaluation. 61
32520578 2020
26
Comment on "Comparison of several biomarkers (MMP-2, MMP-9,the MMP-9 inhibitor TIMP-1, CTX-II, calprotectin, andCOMP) in the synovial fluid and serum of patients withand without septic arthritis" Joint Bone Spine. 2019; 86(2):261-262. 61
32522599 2020
27
Arthroscopic treatment for septic arthritis of the shoulder in a 1-month-old infant: A case report. 61
32534845 2020
28
Trends in antimicrobial resistance among bacteria causing septic arthritis in adults in a single center: A 15-years retrospective analysis. 61
31784870 2020
29
Feeding Vessel Sign - A Radiological sign of septic Pulmonary Embolism. 61
32521011 2020
30
Molecular epidemiology and evolution of Haemophilus influenzae. 61
31981610 2020
31
Medical and conservative surgical management of bacterial sternoclavicular joint septic arthritis: a case series. 61
32483916 2020
32
Role of different Th17 and Treg downstream signalling pathways in the pathogenesis of Staphylococcus aureus infection induced septic arthritis in mice. 61
32574668 2020
33
Platelet-rich plasma lysate displays antibiofilm properties and restores antimicrobial activity against synovial fluid biofilms in vitro. 61
31922274 2020
34
Frequency of Dosing of Cephalexin for Oral Step-Down Therapy of Pediatric Osteoarticular Infections Caused by Methicillin-Sensitive Staphylococcus Aureus. 61
32398570 2020
35
Neisseria gonorrhoeae Septic Arthritis with Contiguous Infection Consistent with Acute Osteomyelitis. 61
32496386 2020
36
Arthroscopic débridement has similar 30-day complications compared with open arthrotomy for the treatment of native shoulder septic arthritis: a population-based study. 61
32057658 2020
37
Septic arthritis: A case report. 61
31948708 2020
38
Septic arthritis and acute kidney injury: questions. 61
31897712 2020
39
Septic arthritis and acute kidney injury: answers. 61
31897713 2020
40
Septic arthritis in the antimicrobial stewardship era. 61
32236890 2020
41
[Pneumococcal septic arthritis in a patient with mixed connective tissue disease]. 61
32295330 2020
42
Septic arthritis of the hip, an unreported complication of perforated appendicitis: A case report. 61
32563086 2020
43
Septic arthritis in children: Updated epidemiologic, microbiologic, clinical and therapeutic correlations. 61
32184066 2020
44
Functional Outcome for Arthroscopic Treatment of Septic Arthritis of the Wrist. 61
32509421 2020
45
Septic arthritis in a patient after tonsillectomy: A case report. 61
32571631 2020
46
Disseminated septic arthritis caused by Streptococcus equi infection. 61
32513761 2020
47
Septic Arthritis of Native Shoulder and Knee Joint: What Are the Differences in Bacterial Spectrum, Treatment, and Outcome? 61
31841653 2020
48
Soaking of autografts with vancomycin is highly effective on preventing postoperative septic arthritis in patients undergoing ACL reconstruction with hamstrings autografts. 61
32363476 2020
49
Centrifugation may eliminate false-positive leucocyte esterase strip test results caused by inflammatory arthritis in the diagnosis of knee infection: A pilot study. 61
32566145 2020
50
Knee infection following anterior cruciate ligament reconstruction: a cohort study of one thousand, eight hundred and ninety one patients from the single-centre database. 61
32114657 2020
Sources

Variations for Septic Arthritis

About this section
Sources

Expression for Septic Arthritis

About this section
Search GEO for disease gene expression data for Septic Arthritis.
Sources

Pathways for Septic Arthritis

About this section

Pathways related to Septic Arthritis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.02 TREM1 TLR9 TLR5 TLR4 TLR3 TLR2
2
Akt Signaling 63
Show member pathways
 13.42 TLR9 TLR5 TLR4 TLR3 TLR2 ITGA2
3
Integrin Pathway 63
Show member pathways
 13.41 MMP7 MMP3 MMP2 MMP1 ITGA2 CXCR3
4
IL-2 Pathway 63
Show member pathways
 13.21 TREM1 TLR9 TLR5 TLR4 TLR3 TLR2
5
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 12.99 TREM1 TLR9 TLR5 TLR4 TLR3 TLR2
6
Pathways in cancer 36
12.84 RELA MMP2 MMP1 ITGA2 IFNG CXCL8
7
Measles 36
Show member pathways
 12.84 TLR9 TLR4 TLR3 TLR2 RELA IFNG
8
Herpes simplex virus 1 infection 36
12.8 TLR9 TLR3 TLR2 RELA IFNG
9
Degradation of the extracellular matrix 65
Show member pathways
 12.75 MMP7 MMP3 MMP2 MMP1 ITGA2
10
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.75 TLR9 TLR5 TLR4 TLR3 TLR2 RELA
11
NF-KappaB Family Pathway 63
Show member pathways
 12.71 TLR9 TLR5 TLR4 TLR3 TLR2 RELA
12
T cell receptor signaling pathway 36
Show member pathways
 12.61 TLR9 TLR4 TLR2 RELA IFNG
13
Th17 cell differentiation 36
Show member pathways
 12.6 TLR5 TLR4 TLR2 RELA IFNG
14
TRAF Pathway 63
Show member pathways
 12.59 TLR9 TLR5 TLR4 TLR3 TLR2
15
NF-kappaB Signaling 4
12.57 TLR9 TLR3 TLR2 RELA IFNG
16
VEGF Pathway (Qiagen) 63
Show member pathways
 12.42 TLR9 TLR5 TLR4 TLR3 TLR2
17
Shigellosis 36
12.39 TLR5 TLR4 RELA CXCL8
18
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.34 CXCR3 CXCL8 CXCL11 CCL18
19
Salmonella infection (KEGG) 36
12.34 TLR9 TLR5 TLR4 TLR2 RELA CXCL8
20
Toll Comparative Pathway 63
Show member pathways
 12.32 TLR4 TLR3 RELA IFNG CXCL8
21
Proteoglycans in cancer 36
12.3 TLR4 TLR2 MMP2 ITGA2
22
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.28 TLR9 TLR5 TLR4 TLR3 TLR2 RELA
23
Pathogenic Escherichia coli infection 36
12.27 TLR5 TLR4 RELA CXCL8
24
Toxoplasmosis 36
Show member pathways
 12.26 TLR4 TLR2 RELA IFNG
25
Tuberculosis 36
12.25 TLR9 TLR4 TLR2 RELA IFNG
26
NOD-like receptor signaling pathway 36
12.23 TLR4 RELA DEFB4A CXCL8
27
IL-17 Family Signaling Pathways 64
Show member pathways
 12.09 TLR5 TLR2 RELA MMP3 MMP1 IFNG
28
MAPK Pathway 70
Show member pathways
 12.08 TLR9 TLR5 TLR4 TLR3 TLR2 RELA
29
Interleukin-4 and 13 signaling 65
11.99 MMP3 MMP2 MMP1 CXCL8
30
IL27-mediated signaling events 1
Show member pathways
 11.98 TLR9 TLR5 TLR4 TLR3 TLR2 IFNG
31
Amoebiasis 36
11.96 TLR4 TLR2 RELA IFNG CXCL8
32
Matrix Metalloproteinases 1
Show member pathways
 11.92 MMP7 MMP3 MMP2 MMP1
33
Rheumatoid arthritis 36
11.88 TLR4 TLR2 MMP3 MMP1 IFNG CXCL8
34
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.86 TLR4 RELA CXCL8
35
Corticotropin-releasing hormone signaling pathway 1
11.86 TLR4 RELA CXCL8
36
Angiogenesis (CST) 4
11.84 MMP7 MMP3 MMP2
37
Colorectal Cancer Metastasis 63
11.83 TLR9 TLR5 TLR4 TLR3 TLR2 MMP7
38
Glucocorticoid receptor regulatory network 1
11.82 RELA MMP1 IFNG CXCL8
39
Th17 Differentiation 64
Show member pathways
 11.8 TLR9 TLR5 TLR4 TLR3 TLR2 IFNG
40
Pertussis 36
11.76 TLR4 RELA CXCL8
41
Bladder cancer 36 1
11.74 MMP2 MMP1 CXCL8
42
Phagocytosis of Microbes 63
11.73 TLR9 TLR5 TLR4 TLR3 TLR2 ITGA2
43
Cell adhesion_ECM remodeling 22
11.72 MMP7 MMP3 MMP2 MMP1 CXCL8
44
AGE/RAGE pathway 1
11.69 RELA MMP7 MMP2
45
LPA receptor mediated events 1
11.68 RELA MMP2 CXCL8
46
Legionellosis 36
11.68 TLR5 TLR4 TLR2 RELA CXCL8
47
Lung fibrosis 1
11.66 MMP2 CXCL8 CALCA
48
ATF-2 transcription factor network 1
11.59 MMP2 IFNG CXCL8
49
Malaria 36
11.59 TLR9 TLR4 TLR2 IFNG CXCL8
50
MSP-RON Signaling 63
11.53 TLR4 TLR2 IFNG
Sources

GO Terms for Septic Arthritis

About this section

Cellular components related to Septic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.73 TLR4 TLR3 TLR2 MMP7 ITGA2 CXCR3
2 extracellular space GO:0005615 9.7 TLR3 MMP7 MMP3 MMP2 IFNG DEFB4A
3 extracellular matrix GO:0031012 9.55 TLR3 MMP7 MMP3 MMP2 MMP1
4 extracellular region GO:0005576 9.44 TREM1 TLR9 MMP7 MMP3 MMP2 MMP1

Biological processes related to Septic Arthritis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.35 TLR9 TLR5 TLR4 TLR3 TLR2 CXCR3
2 positive regulation of gene expression GO:0010628 10.15 TLR9 TLR4 TLR3 TLR2 IFNG CRP
3 innate immune response GO:0045087 10.14 TREM1 TLR9 TLR5 TLR4 TLR3 TLR2
4 cytokine-mediated signaling pathway GO:0019221 10.08 RELA MMP3 MMP2 MMP1 CXCL8
5 defense response to bacterium GO:0042742 10.08 TLR9 TLR5 TLR4 TLR3 DEFB4A
6 extracellular matrix organization GO:0030198 10.07 MMP7 MMP3 MMP2 MMP1 ITGA2
7 cellular response to lipopolysaccharide GO:0071222 10.04 TLR5 TLR4 RELA CXCL8 CXCL11
8 chemotaxis GO:0006935 10.02 DEFB4A CXCR3 CXCL8 CXCL11 CCL18
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.02 TLR9 TLR4 TLR3 TLR2 RELA
10 defense response to virus GO:0051607 10.01 TLR9 TLR3 RELA IFNG
11 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.01 TLR9 TLR4 TLR3 RELA
12 defense response GO:0006952 10.01 TLR3 RELA DEFB4A CXCL8 CXCL11
13 cellular response to tumor necrosis factor GO:0071356 9.99 RELA CXCL8 CCL18 CALCA
14 immune response GO:0006955 9.97 TLR9 TLR4 TLR2 IFNG DEFB4A CXCR3
15 cellular response to interferon-gamma GO:0071346 9.95 TLR4 TLR3 TLR2 CCL18
16 chemokine-mediated signaling pathway GO:0070098 9.95 CXCR3 CXCL8 CXCL11 CCL18
17 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.94 TLR9 TLR4 TLR3 RELA
18 extracellular matrix disassembly GO:0022617 9.93 MMP7 MMP3 MMP2 MMP1
19 cellular response to mechanical stimulus GO:0071260 9.91 TLR5 TLR4 TLR3 MMP7 ITGA2
20 defense response to Gram-negative bacterium GO:0050829 9.9 TLR9 TLR4 DEFB4A
21 cellular response to interleukin-1 GO:0071347 9.9 RELA CXCL8 CCL18
22 positive regulation of JNK cascade GO:0046330 9.9 TLR9 TLR4 TLR3
23 neutrophil chemotaxis GO:0030593 9.9 CXCL8 CXCL11 CCL18
24 positive regulation of interleukin-6 production GO:0032755 9.9 TLR9 TLR4 TLR3 TLR2
25 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.89 DEFB4A CXCL8 CXCL11
26 positive regulation of protein complex assembly GO:0031334 9.88 MMP3 MMP1 IFNG
27 positive regulation of tumor necrosis factor production GO:0032760 9.88 TLR9 TLR4 TLR3 TLR2
28 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.88 TLR9 TLR4 TLR3 TLR2 RELA
29 positive regulation of nitric oxide biosynthetic process GO:0045429 9.87 TLR5 TLR4 IFNG
30 positive regulation of interleukin-6 secretion GO:2000778 9.87 TLR4 TLR2 IFNG
31 collagen catabolic process GO:0030574 9.87 MMP7 MMP3 MMP2 MMP1
32 microglial cell activation GO:0001774 9.86 TLR3 TLR2 IFNG
33 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.85 TLR9 TLR5 TLR4 TLR2
34 positive regulation of inflammatory response GO:0050729 9.85 TLR9 TLR4 TLR3 TLR2 ITGA2 IFNG
35 negative regulation of osteoclast differentiation GO:0045671 9.83 TLR4 TLR3 CALCA
36 positive regulation of interleukin-10 production GO:0032733 9.83 TLR9 TLR4 TLR2
37 positive regulation of interferon-beta production GO:0032728 9.83 TLR9 TLR4 TLR3 TLR2
38 toll-like receptor signaling pathway GO:0002224 9.83 TLR9 TLR5 TLR4 TLR3 TLR2
39 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.81 TLR9 TLR4 RELA
40 positive regulation of chemokine production GO:0032722 9.8 TLR9 TLR4 TLR3 TLR2
41 regulation of cytokine secretion GO:0050707 9.78 TLR9 TLR5 TLR2
42 response to molecule of bacterial origin GO:0002237 9.77 TLR9 TLR2 CXCL8
43 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.76 TLR9 TLR4 TLR2 IFNG
44 cellular response to lipoteichoic acid GO:0071223 9.75 TLR4 TLR2 RELA
45 positive regulation of chemokine biosynthetic process GO:0045080 9.73 TLR3 IFNG
46 T cell chemotaxis GO:0010818 9.73 CXCR3 CXCL11
47 positive regulation of interferon-beta biosynthetic process GO:0045359 9.73 TLR9 TLR4 TLR3
48 positive regulation of MHC class II biosynthetic process GO:0045348 9.72 TLR4 IFNG
49 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.71 TLR4 RELA
50 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.71 TLR4 TLR3

Molecular functions related to Septic Arthritis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.39 TLR9 TLR5 TLR4 TLR3 TLR2 RELA
2 identical protein binding GO:0042802 10.04 TLR4 TLR3 TLR2 RELA CXCR3 CRP
3 cytokine activity GO:0005125 9.76 IFNG CXCL8 CXCL11 CCL18
4 serine-type endopeptidase activity GO:0004252 9.71 MMP7 MMP3 MMP2 MMP1
5 amyloid-beta binding GO:0001540 9.65 TLR4 TLR2 ITGA2
6 metallopeptidase activity GO:0008237 9.62 MMP7 MMP3 MMP2 MMP1
7 chemokine activity GO:0008009 9.54 CXCL8 CXCL11 CCL18
8 metalloendopeptidase activity GO:0004222 9.46 MMP7 MMP3 MMP2 MMP1
9 signaling receptor activity GO:0038023 9.35 TREM1 TLR5 TLR4 TLR3 TLR2
10 lipopolysaccharide receptor activity GO:0001875 9.26 TLR4 TLR2
11 endopeptidase activity GO:0004175 8.92 MMP7 MMP3 MMP2 MMP1
Sources

Sources for Septic Arthritis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....